J Surg Res 2020 05 8;249:104-113. Epub 2020 Jan 8.
Elmezzi Graduate School of Molecular Medicine, Manhasset, New York; Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, New York; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York. Electronic address:
From the Elmezzi Graduate School of Molecular Medicine, (J.C., W-L.Y., P.W.); Center for Immunology and Inflammation, (J.C., W-L.Y., Z.W., P.W.) The Feinstein Institute for Medical Research, Manhasset; Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, (W-L.Y., J.T.M., P.W.) Hempstead, New York.
Purpose: We aimed to evaluate its safety in the emergency neurosurgical population at a tertiary hospital center.
Methods: Retrospective analyses of prospectively-collected data were performed on patients ad-mitted to the surgical intensive care unit (SICU) after emergency neurosurgical procedure. We examined patient demographic and clinical
information, survival outcomes, and rates of heparin induced thrombocytopenia and pulmonary embolism in patients who received subcutaneous unfractionated heparin (SCUFH) compared to those who did not.
Results: We identified 223 emergency neurosurgical patients, of which 100 received no anticoagulation (44.84%) and 123 received SCUFH (55.16%). In the SCUFH group, 88 patients received chemoprophylaxis within 24 h and 35 after 24 h. A statistically significant difference was noted with the admission APACHE II score of patients receiving SCUFH to those who did not, but APACHE III and SAPS on admission were shown to have no difference in outcome.
Conclusion: Administration of SCUFH in the emergency neurosurgical population does not increase the risk of bleeding post-operatively and continues to be a safe and effective chemoprophylaxis agent against VTE.
aHepatology and Liver Transplant Unit, Hospital Universitario Austral bLiver Transplant Unit, Hospital Italiano de Buenos Aires cLiver Transplant Unit, Hospital Alemán, Buenos Aires dSchool of Medicine, University of Buenos Aires, Buenos Aires eLiver Transplant Unit, Hospital Allende, Córdoba, Argentina.