Publications by authors named "Joao Saldanha"

11 Publications

  • Page 1 of 1

Primary small cell carcinoma of the vagina.

Case Rep Obstet Gynecol 2013 25;2013:827037. Epub 2013 Jun 25.

Research Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 214, 38025-440 Uberaba, MG, Brazil.

The primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. The survival rate for patients treated in the early stages is around two years. We related the case report of a patient of 41 years with a vegetative and necrotic lesion in left vaginal wall, in middle and upper third, and involvement of parametrium in its proximal third and medium third. A biopsy showed a small cell undifferentiated carcinoma composed of epithelial cells with round nuclei, oval or elongated, hyperchromatic nuclei, with little distinct nucleoli, and scarce cytoplasm. Immunohistochemistry showed positivity for AE1/AE3, CD57, and chromogranin A. The patient received 6 cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after 5 months of followup.
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http://dx.doi.org/10.1155/2013/827037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708421PMC
July 2013

Cellular fibroma of the ovary with multiloculated macroscopic characteristics: case report.

Case Rep Med 2012 11;2012:283948. Epub 2012 Apr 11.

Discipline of Special Pathology, Universidade Federal do Triangulo Mineiro (UFTM), Avenida Getulio Guarita 130, 38045-440 Uberaba, MG, Brazil.

Ovarian fibroma is the commonest benign tumor of the ovarian stroma. The cellular subtype accounts for around 10% of ovarian fibromatous tumors. The cellular fibroma is a tumor of uncertain malignant potential that may recur or be associated with peritoneal implants. Usually these are solid tumors, sometimes with small areas of cystic degeneration. This case is reported to highlight an unusual feature for an ovarian fibroma: the tumor was predominantly cystic with a small solid part; the multiple cavities contents consisted of viscous liquid that solidified under room temperature. The multiloculated cysts, the mucinous contents, and the solid areas simulated a borderline mucinous ovarian tumor on both CT scan and gross pathologic examination.
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http://dx.doi.org/10.1155/2012/283948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332172PMC
August 2012

Morphologic analysis of fetal stress organsin different causes of perinatal death.

Fetal Pediatr Pathol 2012 Feb 25;31(1):30-8. Epub 2011 Oct 25.

General Pathology Department, Triângulo Mineiro Federal University, Uberaba, Minas Gerais State, Brazil.

Complications act as stress-inducers during pregnancy so the fetus can develop functional compensatory mechanisms or morphologic changes. The cases analyzed are with congenital malformations or acute stress; chronic included cases with ascending infection (AI) and perinatal hypoxia/anoxia (PHA). The hematoxylin-eosin (H&E) was done to analyze the vacuolization, and the immunohistochemistry to the phagocytosis. The discreet standard of vacuolization was observed in 52.6% of the cases, 22.1% moderate, and 25.3% severe. The number of macrophages was higher in PHA. Changes in these organs are closely related to the cause of death and to the period during which the harmful agent.
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http://dx.doi.org/10.3109/15513815.2011.619074DOI Listing
February 2012

Synchronous sertoli cell and serous cystadenoma tumors of the ovaries with mixed epithelial and stromal tumor of the kidney: a case report.

Clin Genitourin Cancer 2007 Jun;5(5):338-40

Discipline of Gynecology and Obstetrics, Research Institute of Oncology, Federal University of Triângulo Mineiro Uberaba, Minas Gerais, Brazil.

We present a rare case of a 68-year-old postmenopausal woman with a mobile, hard, and painless pelvic abdominal mass that was palpated to the umbilical scar. Ultrasonography demonstrated a solid mass in the upper pole of the right kidney and a predominantly solid pelvic abdominal mass. Serum testosterone was 413 ng/dL. The patient underwent laparotomy on the renal tumor, which was thought to have a probable ovarian metastasis. Bilateral ovariectomy and right nephrectomy were performed. Immunohistochemical and histopathologic assessment identified a right ovarian Sertoli cell tumor, a left ovarian serous cystadenoma, and a mixed epithelial-stromal tumor in the kidney with positive hormonal receptor. Because our patient had an ovarian neoplasm producing steroids and a kidney tumor expressing hormonal receptors, the hypothesis of possible endocrine dependence in the pathogenesis of mixed epithelial stromal tumor is reinforced.
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http://dx.doi.org/10.3816/cgc.2007.n.014DOI Listing
June 2007

Thickness of the cervical epithelium of autopsied patients with acquired immunodeficiency syndrome.

Ann Diagn Pathol 2007 Aug;11(4):258-61

Tropical Pathology and Public Health Institute, Federal University of Goiàs, 74605-050 Goiânia, Brazil.

Several general pathologic processes that affect the uterine cervix have been described in Brazil and in the world. The aim of the current study was to evaluate morphometrically the cervical epithelium of autopsied patients with AIDS. This is a cross-sectional study of the cervix of 38 women autopsied from 1993 to 2003. We evaluated the cervix of women aged 20 to 40 years, 20 with AIDS (52.63%) and 18 without (47.37%). The inflammatory infiltrate found in the AIDS patients was more accentuated and predominantly composed of monocytes, which is characteristic of chronic inflammation. In addition, necrosis, fibrosis, and metaplasia were also more frequent in these patients. The cervical epithelium was considerably thinner in the AIDS patients. This hypotrophy occurred because of a significantly accentuated reduction in the number and surface area of cells (P < .01). There was still a significant correlation between the thickness of the epithelium and the nutritional status of AIDS patients. General pathologic processes, which affect the cervices of patients with AIDS, especially hypotrophy, could facilitate the penetration of other infectious agents. We suggest that the nutritional status of these patients and the adherence to antiretroviral therapy be routinely evaluated and the use of condoms stimulated even between HIV-positive partners to prevent possible increases in the viral load and reinfections that contribute to the aggravation of the disease.
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http://dx.doi.org/10.1016/j.anndiagpath.2006.09.004DOI Listing
August 2007

Bronchogenic carcinoma of squamous cells in a young pregnant woman.

Ann Diagn Pathol 2006 Aug;10(4):235-8

General Pathology Division, Biological Science Department, Triângulo Mineiro Medical School, Uberaba, MG 38025-180, Brazil.

Lung cancer continues to be the most incident neoplasia in the world and also the most frequent cause of death by cancer, with more than 900000 new cases per year. Women present greater risk of developing bronchogenic carcinoma, possibly because of differences in metabolism of the carcinogens associated with tobacco and also because of hormonal differences because estrogens can promote the appearance of lung cancer, including during pregnancy. We have described the case of a 25-year-old patient who developed squamous cell carcinoma of the lung during her third pregnancy, with a progressive worsening of her general condition and progression until death. We believe that the pregnancy could have contributed to the evolution of the disease, especially because of the increased levels of gestational hormones, particularly the estrogen, because its receptors have an important role in regulating growth and in the differentiation of several tissues facilitating like this, the development of the neoplasia, and complicating its early diagnosis.
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http://dx.doi.org/10.1016/j.anndiagpath.2005.09.014DOI Listing
August 2006

The Lanz endotracheal tube decreases tracheal injury in dogs.

Can J Anaesth 2005 Oct;52(8):878-82

Department of Anesthesiology, School of Medicine, UNESP, District of Rubião Júnior - P.O. Box 530, Zip Code 18618-970 - Botucatu, SP - Brazil.

Purpose: To determine, in dogs anesthetized with nitrous oxide (N2O), (whether the endotracheal tube (ETT) cuffed with a Lanz pressure regulating valve decreases the tracheal consequences of tracheal intubation.

Methods: Sixteen mixed-breed dogs were allocated to two groups according to the ETT used: Control group (n = 8) - Rüsch ETT, and Lanz group (n = 8) - ETT with Lanz pressure regulating valve. The ETT cuffs in both groups were inflated with air to an intracuff pressure of 30 cm H2O. Anesthesia was induced and maintained with pentobarbitone and N2O (1.5 L x min(-1)) and O2 (1 L x min(-1)). ETT cuff pressures were measured before (control) and 60, 120, and 180 min during N2O administration. The dogs were sacrificed, and biopsy specimens from four predetermined areas of the tracheal mucosa in contact with the ETT were collected for light and scanning electron microscopy (SM) examination.

Results: Cuff pressures in the Control group were higher than in the Lanz group at all time points studied (P < 0.001), with an increase over time only in the Control group (P < 0.001). Median neutrophilic inflammatory infiltration values of the epithelial surface, and in the subepithelial layer in contact with the cuff, were higher in the Control group as compared to the Lanz group (3.0 vs 1.0 and 3.0 vs 1.5 respectively) (P < 0.05). On SM examination, median histological grades were higher in the Control group compared to Lanz group (2.9 vs 1.9 respectively), (P < 0.05).

Conclusions: The Lanz ETT decreases tracheal mucosal injury in dogs.
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http://dx.doi.org/10.1007/BF03021785DOI Listing
October 2005

Isospora belli infection: observation of unicellular cysts in mesenteric lymphoid tissues of a Brazilian patient with AIDS and animal inoculation.

J Eukaryot Microbiol 2003 ;50 Suppl:682-4

Department of Biology, Univ of New Mexico, Albuquerque, NM, USA.

We describe the finding of unizoic cysts of Isospora belli in lymphoid tissues of a Brazilian patient with AIDS, and discuss the possibilities of their drug resistance, they being the cause of relapses, and of being an indication for the existence of intermediary or paratenic animal hosts.
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http://dx.doi.org/10.1111/j.1550-7408.2003.tb00686.xDOI Listing
March 2004

[Extraintestinal finding of Isospora belli unizoic cysts in a patient with AIDS: case report].

Rev Soc Bras Med Trop 2003 May-Jun;36(3):409-12. Epub 2003 Jul 31.

University of New Mexico, Albuquerque, NM 87501, USA.

This report describes the presence of Isospora belli unizoic cysts in mesenteric lymph nodes and of gametocytes in the gallbladder epitelium of a 26 year-old Brazilian male patient with Acquired Immune Deficiency Syndrome. This patient had received treatment for several times with sulfamethoxazole-trimethoprim. It is discussed the significance of I. belli tissue cysts as possible foci of resistance of the parasite and their association with the infection relapse even post-treatment with anticoccidian medication.
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http://dx.doi.org/10.1590/s0037-86822003000300014DOI Listing
October 2003