Publications

Compound high-quality criteria: a new vision to guide the development of drugs, current situation.
Drug Discov Today 2016 Apr 21;21(4):573-84. Epub 2016 Jan 21.
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France; Université de Toulouse, UPS, INPT, 31077 Toulouse Cedex 4, France. Electronic address:

Fine tuning of the pH-sensitivity of laponite-doxorubicin nanohybrids by polyelectrolyte multilayer coating.
Mater Sci Eng C Mater Biol Appl 2016 Mar 1;60:348-356. Epub 2015 Dec 1.
CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal. Electronic address:

Why and how have drug discovery strategies in pharma changed? What are the new mindsets?
Drug Discov Today 2016 Feb 14;21(2):239-49. Epub 2015 Sep 14.
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France; Université de Toulouse, UPS, INPT, 31077 Toulouse Cedex 4, France. Electronic address:

Octadecyl functionalized core-shell magnetic silica nanoparticle as a powerful nanocomposite sorbent to extract urinary volatile organic metabolites.
J Chromatogr A 2015 May 14;1393:18-25. Epub 2015 Mar 14.
CQM, Centro de Química da Madeira, Universidade da Madeira, 9000-390 Funchal, Portugal; Centro de Ciências Exatas e de Engenharia da Universidade da Madeira, Campus Universitário da Penteada, 9000-390 Funchal, Portugal. Electronic address:

Synthesis, characterization and solid-state photoluminescence studies of six alkoxy phenylene ethynylene dinuclear palladium(II) rods.
Dalton Trans 2015 Mar;44(9):4003-15
CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, 9000-390 Funchal, Portugal.

RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells.
Colloids Surf B Biointerfaces 2015 Jan 11;125:82-9. Epub 2014 Nov 11.
CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, People's Republic of China. Electronic address:

Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robust stability and pH sensitivity for anticancer drug delivery.
ACS Appl Mater Interfaces 2014 Oct 15;6(19):16687-95. Epub 2014 Sep 15.
CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira , Campus Universitário da Penteada, 9020-105 Funchal, Portugal.

Dendrimer-assisted formation of fluorescent nanogels for drug delivery and intracellular imaging.
Biomacromolecules 2014 Feb 28;15(2):492-9. Epub 2014 Jan 28.
CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira , Campus Universitário da Penteada, 9020-105 Funchal, Portugal.

Insight into the role of N,N-dimethylaminoethyl methacrylate (DMAEMA) conjugation onto poly(ethylenimine): cell viability and gene transfection studies.
J Mater Sci Mater Med 2012 Dec 4;23(12):2967-80. Epub 2012 Sep 4.
CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390, Funchal, Portugal.

Gene delivery into mesenchymal stem cells: a biomimetic approach using RGD nanoclusters based on poly(amidoamine) dendrimers.
Biomacromolecules 2011 Feb 6;12(2):472-81. Epub 2011 Jan 6.
CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, Funchal, Portugal.


Receptor-mediated gene delivery using PAMAM dendrimers conjugated with peptides recognized by mesenchymal stem cells.
Mol Pharm 2010 Jun;7(3):763-74
CQM-Centro de Quimica da Madeira, MMRG, Departamento de Quimica, Universidade da Madeira, Campus Universitario da Penteada, 9000-390 Funchal, Portugal.

Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells.
J Control Release 2010 May 6;144(1):55-64. Epub 2010 Feb 6.
CQM - Centro de Química da Madeira, MMRG, Departamento de Química, Universidade da Madeira, Campus Universitário da Penteada, 9000-390 Funchal, Portugal.

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