Publications

Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity.
Toxicol Lett 2017 Nov 10;283:21-31. Epub 2017 Nov 10.
Glial Cell Biology, Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular, The Discoveries Centre for Regeneration and Precision Medicine - Porto campus, Universidade do Porto, Porto, Portugal. Electronic address:

Structure and function of a novel antioxidant peptide from the skin of tropical frogs.
Free Radic Biol Med 2017 Nov 21;115:68-79. Epub 2017 Nov 21.
Glial Cell Biology Lab, Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Área de Morfologia, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília, DF, Brazil. Electronic address:

Collar occupancy: A new quantitative imaging tool for morphometric analysis of oligodendrocytes.
J Neurosci Methods 2017 Nov 22;294:122-135. Epub 2017 Nov 22.
Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal; International Iberian Nanotechnology Laboratory (INL), Braga, Portugal. Electronic address:

Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype.
Sci Signal 2017 Mar 28;10(472). Epub 2017 Mar 28.
Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 208 4200-135 Porto, Portugal.



Assessment of postoperative pain after reciprocating or rotary NiTi instrumentation of root canals: a randomized, controlled clinical trial.
Clin Oral Investig 2016 Nov 19;20(8):1987-1993. Epub 2015 Dec 19.
Dental School, Federal University of Amazonas, R Mins Waldemar Pedrosa, n. 1539, Praça 14 de Janeiro, Manaus, AM, CEP: 69025-050, Brazil.


Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia.
Mol Pharmacol 2016 Jan 19;89(1):84-93. Epub 2015 Oct 19.
Research Institute for Medicines (iMed.UL) (A.B., A.F., D.B.) and Department of Biochemistry and Human Biology (A.F., D.B.), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal; Laboratory of Environmental Toxicology, Department of Pharmacology, and Chemistry and Biochemistry, University of California San Diego, La Jolla, California (S.C., M-F.Y., N.N., R.H.T.); Departamento de Biologia Experimental, Faculty of Medicine (H.S.D., J.R.) and Instituto de Biologia Molecular e Celular (J.R.), University of Porto, Porto, Portugal; Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and Faculty of Pharmacy, Laval University, Québec, QC, Canada (O.B.)

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade.
Hum Mol Genet 2015 Oct 5;24(20):5891-900. Epub 2015 Aug 5.
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal, Instituto de Investigação e Inovação em Saúde (i3S), Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal,

Brain activation of the defensive and appetitive survival systems in obsessive compulsive disorder.
Brain Imaging Behav 2015 Jun;9(2):255-63
Department of Counseling and Applied Educational Psychology, Bouvé College of Health Sciences, Northeastern University, 404 Int'l Village, Boston, MA, 02115, USA,

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour.
BMC Cancer 2015 Jun 5;15:456. Epub 2015 Jun 5.
i3S-Instituto de Investigação e Inovação em Saúde/INEB-Institute of Biomedical Engineering, University of Porto, Porto, Portugal.

c-Src function is necessary and sufficient for triggering microglial cell activation.
Glia 2015 Mar 24;63(3):497-511. Epub 2014 Nov 24.
Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal; Program of Neurosciences, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Faculty of Medicine, Centre of Ophthalmology and Vision Sciences, Institute for Biomedical Imaging and Life Sciences (IBILI), University of Coimbra, Coimbra, Portugal.

c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity.
Free Radic Biol Med 2015 Feb 5;79:45-55. Epub 2014 Dec 5.
Neurosciences Program, Fluminense Federal University, Niterói 24210-130, Brazil; Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói 24210-130, Brazil. Electronic address:

Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.
Hum Mol Genet 2015 Jan 20;24(1):100-17. Epub 2014 Aug 20.
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães and

Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors.
Mol Neurobiol 2014 Feb 28;49(1):424-39. Epub 2013 Aug 28.
Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculdade de Farmácia, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003, Lisbon, Portugal.

Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.
Brain 2012 Dec 20;135(Pt 12):3567-83. Epub 2012 Nov 20.
Department of Biology, Institute of Molecular Health Sciences, Cell Biology, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich,Switzerland.

Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion.
J Biol Chem 2012 Nov 19;287(46):38680-94. Epub 2012 Sep 19.
Program of Neurosciences and Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niterói, 24020-971, Brazil.




Endodontic Treatment of Maxillary Premolar with Three Root Canals Using Optical Microscope and NiTi Rotatory Files System.
Case Rep Dent 2013 3;2013:710408. Epub 2013 Dec 3.
Department of Dental Materials and Prosthodontics, Ribeirão Preto School of Dentistry, University of São Paulo, 14040-900 Ribeirão Preto, SP, Brazil.


Extracellular environment contribution to astrogliosis-lessons learned from a tissue engineered 3D model of the glial scar.
Front Cell Neurosci 2015 29;9:377. Epub 2015 Sep 29.
Instituto de Engenharia Biomédica (INEB), Universidade do Porto Porto, Portugal ; Instituto de Investigação e Inovação em Saúde, Universidade do Porto Porto, Portugal ; Faculdade de Engenharia, Universidade do Porto Porto, Portugal ; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Porto, Portugal.

Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and α6β1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties.
Front Cell Neurosci 2016 15;10:284. Epub 2016 Dec 15.
Centre for Neuroscience and Cell Biology, University of CoimbraCoimbra, Portugal; Department of Pathology, University of Southern CaliforniaLos Angeles, CA, USA; Department of Neurological Surgery, University of Southern CaliforniaLos Angeles, CA, USA.

Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons.
Biochim Biophys Acta 2017 06 6;1860(6):685-694. Epub 2017 Mar 6.
Gene Regulation Group, IBMC - Instituto de Biologia Celular e Molecular, Porto, Portugal; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal. Electronic address:

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