Joao Relvas

Joao Relvas

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Joao Relvas

Joao Relvas

Publications by authors named "Joao Relvas"

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59Publications

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Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke.

Brain Pathol 2018 Jul 24;28(4):569-580. Epub 2017 Oct 24.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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July 2018

Jmy regulates oligodendrocyte differentiation via modulation of actin cytoskeleton dynamics.

Glia 2018 May 6. Epub 2018 May 6.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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May 2018

Redox tuning of Ca signaling in microglia drives glutamate release during hypoxia.

Free Radic Biol Med 2018 Apr 2;118:137-149. Epub 2018 Mar 2.

Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC) and The Discoveries Centre for Regeneration and Precision Medicine - Porto campus, Universidade do Porto, Porto, Portugal. Electronic address:

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April 2018

Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity.

Toxicol Lett 2018 Feb 10;283:21-31. Epub 2017 Nov 10.

Glial Cell Biology, Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular, The Discoveries Centre for Regeneration and Precision Medicine - Porto campus, Universidade do Porto, Porto, Portugal. Electronic address:

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February 2018

Structure and function of a novel antioxidant peptide from the skin of tropical frogs.

Free Radic Biol Med 2018 Feb 21;115:68-79. Epub 2017 Nov 21.

Glial Cell Biology Lab, Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Área de Morfologia, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília, DF, Brazil. Electronic address:

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February 2018

Mechanical plasticity during oligodendrocyte differentiation and myelination.

Glia 2018 01 21;66(1):5-14. Epub 2017 Sep 21.

International Iberian Nanotechnology Laboratory - INL, Braga, Portugal.

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January 2018

Collar occupancy: A new quantitative imaging tool for morphometric analysis of oligodendrocytes.

J Neurosci Methods 2018 Jan 22;294:122-135. Epub 2017 Nov 22.

Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal; International Iberian Nanotechnology Laboratory (INL), Braga, Portugal. Electronic address:

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January 2018

The ascorbate transporter SVCT2 to target microglia-dependent inflammation.

Oncotarget 2017 Nov 7;8(59):99217-99218. Epub 2017 Nov 7.

Camila C. Portugal: Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.

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November 2017

Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons.

Biochim Biophys Acta Gene Regul Mech 2017 Jun 6;1860(6):685-694. Epub 2017 Mar 6.

Gene Regulation Group, IBMC - Instituto de Biologia Celular e Molecular, Porto, Portugal; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal. Electronic address:

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June 2017

dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation.

PLoS Genet 2017 Mar 7;13(3):e1006647. Epub 2017 Mar 7.

i3S -Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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March 2017

Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype.

Sci Signal 2017 Mar 28;10(472). Epub 2017 Mar 28.

Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 208 4200-135 Porto, Portugal.

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March 2017

Heterocellular Contacts with Mouse Brain Endothelial Cells Laminin and α6β1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties.

Front Cell Neurosci 2016 15;10:284. Epub 2016 Dec 15.

Centre for Neuroscience and Cell Biology, University of CoimbraCoimbra, Portugal; Department of Pathology, University of Southern CaliforniaLos Angeles, CA, USA; Department of Neurological Surgery, University of Southern CaliforniaLos Angeles, CA, USA.

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December 2016

Assessment of postoperative pain after reciprocating or rotary NiTi instrumentation of root canals: a randomized, controlled clinical trial.

Clin Oral Investig 2016 Nov 19;20(8):1987-1993. Epub 2015 Dec 19.

Dental School, Federal University of Amazonas, R Mins Waldemar Pedrosa, n. 1539, Praça 14 de Janeiro, Manaus, AM, CEP: 69025-050, Brazil.

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November 2016

Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair.

Front Cell Dev Biol 2016 28;4:71. Epub 2016 Jun 28.

Glial Cell Biology Group, Instituto de Biologia Molecular e Celular, Universidade do PortoPorto, Portugal; Glial Cell Biology Group, Instituto de Investigação e Inovação em Saúde (I3S), Universidade do PortoPorto, Portugal.

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August 2016

Corrigendum: Oligodendrocyte, Astrocyte and Microglia Crosstalk in Myelin Development, Damage, and Repair.

Front Cell Dev Biol 2016 19;4:79. Epub 2016 Jul 19.

Glial Cell Biology Group, Instituto de Biologia Molecular e Celular, Universidade do PortoPorto, Portugal; Glial Cell Biology Group, Instituto de Investigação e Inovação em Saúde, Universidade do PortoPorto, Portugal.

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August 2016

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia.

Mol Pharmacol 2016 Jan 19;89(1):84-93. Epub 2015 Oct 19.

Research Institute for Medicines (iMed.UL) (A.B., A.F., D.B.) and Department of Biochemistry and Human Biology (A.F., D.B.), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal; Laboratory of Environmental Toxicology, Department of Pharmacology, and Chemistry and Biochemistry, University of California San Diego, La Jolla, California (S.C., M-F.Y., N.N., R.H.T.); Departamento de Biologia Experimental, Faculty of Medicine (H.S.D., J.R.) and Instituto de Biologia Molecular e Celular (J.R.), University of Porto, Porto, Portugal; Laboratory of Molecular Pharmacology, CHU de Québec Research Centre and Faculty of Pharmacy, Laval University, Québec, QC, Canada (O.B.)

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January 2016

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade.

Hum Mol Genet 2015 Oct 5;24(20):5891-900. Epub 2015 Aug 5.

Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal, Instituto de Investigação e Inovação em Saúde (i3S), Department of Pathology and Oncology, Medical Faculty of the University of Porto, Porto, Portugal,

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October 2015

Extracellular environment contribution to astrogliosis-lessons learned from a tissue engineered 3D model of the glial scar.

Front Cell Neurosci 2015 29;9:377. Epub 2015 Sep 29.

Instituto de Engenharia Biomédica (INEB), Universidade do Porto Porto, Portugal ; Instituto de Investigação e Inovação em Saúde, Universidade do Porto Porto, Portugal ; Faculdade de Engenharia, Universidade do Porto Porto, Portugal ; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Porto, Portugal.

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October 2015

Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions.

Glia 2015 Jul 2;63(7):1155-65. Epub 2015 Mar 2.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal.

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July 2015

Brain activation of the defensive and appetitive survival systems in obsessive compulsive disorder.

Brain Imaging Behav 2015 Jun;9(2):255-63

Department of Counseling and Applied Educational Psychology, Bouvé College of Health Sciences, Northeastern University, 404 Int'l Village, Boston, MA, 02115, USA,

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June 2015

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour.

BMC Cancer 2015 Jun 5;15:456. Epub 2015 Jun 5.

i3S-Instituto de Investigação e Inovação em Saúde/INEB-Institute of Biomedical Engineering, University of Porto, Porto, Portugal.

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June 2015

c-Src function is necessary and sufficient for triggering microglial cell activation.

Glia 2015 Mar 24;63(3):497-511. Epub 2014 Nov 24.

Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal; Program of Neurosciences, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Faculty of Medicine, Centre of Ophthalmology and Vision Sciences, Institute for Biomedical Imaging and Life Sciences (IBILI), University of Coimbra, Coimbra, Portugal.

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March 2015

Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder.

Brain 2015 Mar 6;138(Pt 3):798-811. Epub 2015 Jan 6.

1 Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Portugal 5 ICNAS, Brain Imaging Network of Portugal

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March 2015

c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity.

Free Radic Biol Med 2015 Feb 5;79:45-55. Epub 2014 Dec 5.

Neurosciences Program, Fluminense Federal University, Niterói 24210-130, Brazil; Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói 24210-130, Brazil. Electronic address:

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February 2015

Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.

Hum Mol Genet 2015 Jan 20;24(1):100-17. Epub 2014 Aug 20.

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães and

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January 2015

Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors.

Mol Neurobiol 2014 Feb 28;49(1):424-39. Epub 2013 Aug 28.

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculdade de Farmácia, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003, Lisbon, Portugal.

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February 2014

Endodontic Treatment of Maxillary Premolar with Three Root Canals Using Optical Microscope and NiTi Rotatory Files System.

Case Rep Dent 2013 3;2013:710408. Epub 2013 Dec 3.

Department of Dental Materials and Prosthodontics, Ribeirão Preto School of Dentistry, University of São Paulo, 14040-900 Ribeirão Preto, SP, Brazil.

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December 2013

Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination.

Mol Neurobiol 2013 Apr 21;47(2):632-44. Epub 2012 Oct 21.

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Av. Professor Gama Pinto, 1649-003 Lisbon, Portugal.

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April 2013

Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.

Brain 2012 Dec 20;135(Pt 12):3567-83. Epub 2012 Nov 20.

Department of Biology, Institute of Molecular Health Sciences, Cell Biology, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich,Switzerland.

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December 2012

Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion.

J Biol Chem 2012 Nov 19;287(46):38680-94. Epub 2012 Sep 19.

Program of Neurosciences and Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niterói, 24020-971, Brazil.

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November 2012

Identification of new interacting partners for atypical Rho GTPases: a SILAC-based approach.

Methods Mol Biol 2012 ;827:305-17

Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.

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April 2012

[Cognition, social cognition and functioning in schizophrenia].

Acta Med Port 2010 Nov-Dec;23(6):1043-58. Epub 2010 Dec 28.

Grupo de Trabalho em Esquizofrenia, Sociedade Portuguesa de Psiquiatria e Saúde Mental.

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October 2011

Obsessive Compulsive Disorder as a functional interhemispheric imbalance at the thalamic level.

Med Hypotheses 2011 Sep 6;77(3):445-7. Epub 2011 Jul 6.

Neuropsychophysiology Laboratory, CIPsi, School of Psychology (EPsi), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.

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September 2011

The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.

J Neurosci 2011 Mar;31(13):5120-30

Institute of Cell Biology, Department of Biology, Eidgenössische Technische Hochschule Zürich, CH-8093 Zürich, Switzerland.

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March 2011

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination.

Science 2010 Jun 6;328(5984):1415-8. Epub 2010 May 6.

Institute of Cell Biology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, CH-8093 Zürich, Switzerland.

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June 2010

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.

J Neurosci 2010 Mar;30(11):4120-31

Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zürich, CH-8093 Zürich, Switzerland.

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March 2010

BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype.

J Neurosci Res 2009 Jul;87(9):1986-96

Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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July 2009

The function of RhoGTPases in axon ensheathment and myelination.

Glia 2008 Nov;56(14):1508-17

DIBIT, San Raffaele Scientific Institute, Milano, Italy.

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November 2008

Small Rho GTPases are key regulators of peripheral nerve biology in health and disease.

J Peripher Nerv Syst 2008 Sep;13(3):188-99

Institute of Cell Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.

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September 2008

Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.

J Neurosci 2006 Oct;26(40):10110-9

Institute for Cell Biology, Department of Biology, Federal Institute of Technology (ETH) Zurich, CH-8093 Zurich, Switzerland.

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October 2006

Brain blood flow SPET imaging in heroin abusers.

Ann N Y Acad Sci 2006 Aug;1074:466-77

Pharmacology Institute, IBILI, Faculty of Medicine of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal.

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August 2006

Regulation of neural progenitor proliferation and survival by beta1 integrins.

J Cell Sci 2005 Jun 31;118(Pt 12):2589-99. Epub 2005 May 31.

Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Hönggerberg, Zürich.

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June 2005

Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance.

Development 2004 Jul;131(14):3433-44

Department of Medical Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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July 2004

CNS integrins switch growth factor signalling to promote target-dependent survival.

Nat Cell Biol 2002 Nov;4(11):833-41

Department of Medical Genetics and Center for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK.

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November 2002