Joannes F Jacobs

Joannes F M Jacobs

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Joannes F Jacobs

Joannes F M Jacobs

Publications by authors named "Joannes F M Jacobs"

62Publications

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1PubMed Central Citations

Integrating Serum Protein Electrophoresis with Mass Spectrometry, A New Workflow for M-Protein Detection and Quantification.

J Proteome Res 2020 Jan 14. Epub 2020 Jan 14.

Department of Neurology , Erasmus MC University Medical Center , 3015 GD Rotterdam , The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.9b00705DOI Listing
January 2020

Method comparison of four clinically available assays for serum free light chain analysis.

Clin Chem Lab Med 2019 Dec;58(1):85-94

Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2019-0533DOI Listing
December 2019

Broad Bands Observed in Serum Electrophoresis Should Not Be Taken .

Clin Chem 2019 05;65(5):618-621

Department of Laboratory Medicine, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1373/clinchem.2018.297176DOI Listing
May 2019

Standardization and harmonization of autoimmune diagnostics.

Clin Chem Lab Med 2018 09;56(10):1563-1567

Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-0807DOI Listing
September 2018

Reference ranges of the Sebia free light chain ratio in patients with chronic kidney disease.

Clin Chem Lab Med 2018 08;56(9):e232-e234

Department of Laboratory Medicine, Radboud University Medical Center, Laboratory Medical Immunology (route 469), Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands, Phone: +31 (0)24-3617414, Fax: +31 (0)24-3619415.

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http://dx.doi.org/10.1515/cclm-2018-0040DOI Listing
August 2018

Analytical validation of the Hevylite assays for M-protein quantification.

Clin Chem Lab Med 2018 06;56(7):1169-1175

Medical Immunologist, Head of Immunochemistry Laboratory, Sanquin Diagnostic Services, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.

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http://www.degruyter.com/view/j/cclm.2018.56.issue-7/cclm-20
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http://dx.doi.org/10.1515/cclm-2017-0817DOI Listing
June 2018

Development of a Targeted Mass-Spectrometry Serum Assay To Quantify M-Protein in the Presence of Therapeutic Monoclonal Antibodies.

J Proteome Res 2018 03 15;17(3):1326-1333. Epub 2018 Feb 15.

Department of Neurology, Erasmus MC University Medical Center , Rotterdam 3015 GE, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.7b00890DOI Listing
March 2018

Evaluation of a new free light chain ELISA assay: bringing coherence with electrophoretic methods.

Clin Chem Lab Med 2018 01;56(2):312-322

Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2017-0339DOI Listing
January 2018

Recognition and management of common, rare, and novel serum protein electrophoresis and immunofixation interferences.

Clin Biochem 2018 Jan 24;51:72-79. Epub 2017 Aug 24.

Department of Hematology, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1016/j.clinbiochem.2017.08.013DOI Listing
January 2018

Dendritic Cells as Vaccines: Key Regulators of Tolerance and Immunity.

Mediators Inflamm 2016 31;2016:5789725. Epub 2016 May 31.

Department of Laboratory Medicine, Radboudumc, Nijmegen, Netherlands.

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http://dx.doi.org/10.1155/2016/5789725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906213PMC
June 2017

Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study.

Immun Ageing 2017 22;14. Epub 2017 Feb 22.

Departments of Rheumatology and Clinical Immunology and Translational Immunology Groningen (TRIGR), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands.

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http://dx.doi.org/10.1186/s12979-017-0087-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322590PMC
February 2017

Fast, robust and high-resolution glycosylation profiling of intact monoclonal IgG antibodies using nanoLC-chip-QTOF.

Clin Chim Acta 2016 Oct 22;461:90-7. Epub 2016 Jul 22.

Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboudumc, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.07.015DOI Listing
October 2016

Quantitative measurement of immunoglobulins and free light chains using mass spectrometry.

Anal Chem 2015 Aug 28;87(16):8268-74. Epub 2015 Jul 28.

‡Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.5b01263DOI Listing
August 2015

Long-lasting multifunctional CD8 T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination.

Oncoimmunology 2016;5(1):e1067745. Epub 2015 Aug 12.

Radboud University Medical Center, Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherands; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherands.

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http://dx.doi.org/10.1080/2162402X.2015.1067745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760336PMC
August 2015

Anti-SSA antibodies are present in immunoglobulin preparations.

Transfusion 2015 Apr 13;55(4):832-7. Epub 2014 Nov 13.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://doi.wiley.com/10.1111/trf.12922
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http://dx.doi.org/10.1111/trf.12922DOI Listing
April 2015

Antigen excess in modern immunoassays: to anticipate on the unexpected.

Autoimmun Rev 2015 Feb 18;14(2):160-7. Epub 2014 Oct 18.

Central Diagnostic Laboratory, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2014.10.018DOI Listing
February 2015

Reply to Berlanga et al. (DOI 10.1515/cclm-2014-0420).

Clin Chem Lab Med 2014 Nov;52(11):e247-8

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http://dx.doi.org/10.1515/cclm-2014-0599DOI Listing
November 2014

Relatively restricted migration of polyclonal IgG4 may mimic a monoclonal gammopathy in IgG4-related disease.

Am J Clin Pathol 2014 Jul;142(1):76-81

Department of Pathology, University of Michigan Hospital and Health Systems, Ann Arbor.

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http://dx.doi.org/10.1309/AJCP41XCVBHEQCELDOI Listing
July 2014

Severe exacerbation of Crohn's disease during sunitinib treatment.

Eur J Gastroenterol Hepatol 2014 Feb;26(2):234-6

Departments of aMedical Oncology bPathology cTumor Immunology dLaboratory Medicine eGastroenterology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0b013e328365ac54DOI Listing
February 2014

Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma.

Cancer Res 2012 Dec 24;72(23):6102-10. Epub 2012 Sep 24.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2479DOI Listing
December 2012

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

Lancet Oncol 2012 Jan;13(1):e32-42

Department of Tumour Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands.

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http://dx.doi.org/10.1016/S1470-2045(11)70155-3DOI Listing
January 2012

Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients.

Clin Cancer Res 2011 Sep 19;17(17):5725-35. Epub 2011 Jul 19.

Department of Medical Oncology,Nijmegen Centre for Molecular Life Sciences, and Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1261DOI Listing
September 2011

Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents.

Clin Cancer Res 2011 Feb 21;17(4):841-8. Epub 2010 Dec 21.

Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2227DOI Listing
February 2011

Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients.

Clin Cancer Res 2010 Oct 24;16(20):5067-78. Epub 2010 Aug 24.

Department of Medical Oncology, Laboratory of Medical Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1757DOI Listing
October 2010

Prognostic significance and mechanism of Treg infiltration in human brain tumors.

J Neuroimmunol 2010 Aug;225(1-2):195-9

Nijmegen Centre for Molecular Life Sciences, Department of Tumor Immunology, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2010.05.020DOI Listing
August 2010

Detecting only light chains, now what?

Clin Chem 2010 Aug;56(8):1368

Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2010.148494
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http://dx.doi.org/10.1373/clinchem.2010.148494DOI Listing
August 2010

Regulation of MYCN expression in human neuroblastoma cells.

BMC Cancer 2009 Jul 18;9:239. Epub 2009 Jul 18.

Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Donders Institute for Brain, Cognition and Behaviour, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands.

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http://dx.doi.org/10.1186/1471-2407-9-239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720985PMC
July 2009

Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.

Cancer Immunol Immunother 2009 Jan 5;58(1):145-51. Epub 2008 Apr 5.

Department of Pediatric Hemato-oncology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00262-008-0506-5DOI Listing
January 2009

Toll-like receptor signalling on Tregs: to suppress or not to suppress?

Immunology 2008 Aug 28;124(4):445-52. Epub 2008 Jun 28.

Tumor Immunology Laboratory, Radboud University Nijmegen Medical Centre, Department of Pediatric Hemato-Oncology, Nihmegen, The Netherlands.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02871.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492951PMC
August 2008

Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model.

Int J Cancer 2008 Apr;122(8):1794-802

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1002/ijc.23284
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http://dx.doi.org/10.1002/ijc.23284DOI Listing
April 2008

Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients.

Pediatr Blood Cancer 2007 Dec;49(7):924-7

Department of Pediatric Hemato-Oncology, Nijmegen Centre of Molecular Life Sciences, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/pbc.21246DOI Listing
December 2007

Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR.

Int J Cancer 2007 Jan;120(1):67-74

Department of Pediatric Hemato-Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/ijc.22118DOI Listing
January 2007