Joanne M Morrisey

Joanne M Morrisey

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Joanne M Morrisey

Joanne M Morrisey

Publications by authors named "Joanne M Morrisey"

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Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.

PLoS One 2019 9;14(4):e0214023. Epub 2019 Apr 9.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456166PMC
December 2019

Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis.

ACS Infect Dis 2019 04 28;5(4):550-558. Epub 2019 Jan 28.

Center for Molecular Parasitology, Department of Microbiology and Immunology , Drexel University College of Medicine , 2900 Queen Lane , Philadelphia , Pennsylvania 19129 , United States of America.

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http://dx.doi.org/10.1021/acsinfecdis.8b00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461493PMC
April 2019

The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in .

J Biol Chem 2018 05 6;293(21):8128-8137. Epub 2018 Apr 6.

From the Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.

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http://dx.doi.org/10.1074/jbc.RA118.002552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971461PMC
May 2018

Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/AAC.01220-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192125PMC
January 2017

Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p.

PLoS One 2016 25;11(3):e0152197. Epub 2016 Mar 25.

Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807763PMC
August 2016

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.

Antimicrob Agents Chemother 2016 08 22;60(8):4853-9. Epub 2016 Jul 22.

Departments of Physiology and Pharmacology, Molecular Microbiology and Immunology, and Emergency Medicine, Oregon Health & Science University, Portland, Oregon, USA VA Medical Center, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.00791-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958223PMC
August 2016

Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum.

PLoS Pathog 2016 05 26;12(5):e1005647. Epub 2016 May 26.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881962PMC
May 2016

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Am J Trop Med Hyg 2015 Jun 27;92(6):1195-201. Epub 2015 Apr 27.

Departments of Physiology and Pharmacology, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon; Departments of Medicine, Pathology, and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania; VA Medical Center, Portland, Oregon

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http://dx.doi.org/10.4269/ajtmh.14-0553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458825PMC
June 2015

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.

Antimicrob Agents Chemother 2015 Apr 20;59(4):1977-82. Epub 2015 Jan 20.

Departments of Physiology and Pharmacology, Molecular Microbiology, and Immunology, Oregon Health & Science University, Portland, Oregon, USA VA Medical Center, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.04149-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356778PMC
April 2015

Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.

Cell Rep 2015 Apr 2;11(1):164-74. Epub 2015 Apr 2.

Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394047PMC
April 2015

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

J Biol Chem 2014 Dec 28;289(50):34827-37. Epub 2014 Oct 28.

From the Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129,

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http://dx.doi.org/10.1074/jbc.M114.615831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263882PMC
December 2014

Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

Mol Biochem Parasitol 2012 Sep 26;185(1):48-51. Epub 2012 May 26.

Center for Molecular Parasitology and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433233PMC
September 2012

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.

J Biol Chem 2011 Dec 7;286(48):41312-22. Epub 2011 Oct 7.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1074/jbc.M111.290973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308843PMC
December 2011

Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Eukaryot Cell 2011 Aug 17;10(8):1053-61. Epub 2011 Jun 17.

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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http://ec.asm.org/content/early/2011/06/17/EC.05049-11.full.
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http://ec.asm.org/cgi/doi/10.1128/EC.05049-11
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http://dx.doi.org/10.1128/EC.05049-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165440PMC
August 2011

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Mol Biochem Parasitol 2011 May 18;177(1):29-34. Epub 2011 Jan 18.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2011.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057331PMC
May 2011

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

Mol Biochem Parasitol 2010 Dec 30;174(2):150-3. Epub 2010 Jul 30.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2010.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950219PMC
December 2010

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.

Antimicrob Agents Chemother 2010 Dec 20;54(12):5281-7. Epub 2010 Sep 20.

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1128/AAC.00937-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981233PMC
December 2010

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Nature 2010 Aug;466(7307):774-8

Department of Molecular Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1038/nature09301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917841PMC
August 2010

Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.

J Chem Inf Model 2010 May;50(5):840-9

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1021/ci100039kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881581PMC
May 2010

Host-parasite interactions revealed by Plasmodium falciparum metabolomics.

Cell Host Microbe 2009 Feb;5(2):191-9

Department of Molecular Biology, 2Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1016/j.chom.2009.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737466PMC
February 2009

The validity of mitochondrial dehydrogenases as antimalarial drug targets.

Trends Parasitol 2008 Jan 26;24(1):8-9. Epub 2007 Nov 26.

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http://dx.doi.org/10.1016/j.pt.2007.10.005DOI Listing
January 2008

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Nature 2007 Mar;446(7131):88-91

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1038/nature05572DOI Listing
March 2007

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.

Proc Natl Acad Sci U S A 2006 Mar 17;103(13):4852-7. Epub 2006 Mar 17.

Department of Biochemistry and Biological Structure, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.0510907103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458759PMC
March 2006

Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.

J Travel Med 2003 Nov-Dec;10(6):353-5

Division of Communicable Disease, Wisconsin State Laboratory of Hygiene, Madison, WI, USA.

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http://dx.doi.org/10.2310/7060.2003.9318DOI Listing
March 2004

A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites.

Mol Biochem Parasitol 2004 Jan;133(1):15-26

Department of Pathology, Michael Heidelberger Division, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2003.08.009DOI Listing
January 2004