Joanna Wardlaw

Joanna Wardlaw

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Joanna Wardlaw

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Genetic architecture of subcortical brain structures in 38,851 individuals.

Authors:
Claudia L Satizabal Hieab H H Adams Derrek P Hibar Charles C White Maria J Knol Jason L Stein Markus Scholz Muralidharan Sargurupremraj Neda Jahanshad Gennady V Roshchupkin Albert V Smith Joshua C Bis Xueqiu Jian Michelle Luciano Edith Hofer Alexander Teumer Sven J van der Lee Jingyun Yang Lisa R Yanek Tom V Lee Shuo Li Yanhui Hu Jia Yu Koh John D Eicher Sylvane Desrivières Alejandro Arias-Vasquez Ganesh Chauhan Lavinia Athanasiu Miguel E Rentería Sungeun Kim David Hoehn Nicola J Armstrong Qiang Chen Avram J Holmes Anouk den Braber Iwona Kloszewska Micael Andersson Thomas Espeseth Oliver Grimm Lucija Abramovic Saud Alhusaini Yuri Milaneschi Martina Papmeyer Tomas Axelsson Stefan Ehrlich Roberto Roiz-Santiañez Bernd Kraemer Asta K Håberg Hannah J Jones G Bruce Pike Dan J Stein Allison Stevens Janita Bralten Meike W Vernooij Tamara B Harris Irina Filippi A Veronica Witte Tulio Guadalupe Katharina Wittfeld Thomas H Mosley James T Becker Nhat Trung Doan Saskia P Hagenaars Yasaman Saba Gabriel Cuellar-Partida Najaf Amin Saima Hilal Kwangsik Nho Nazanin Mirza-Schreiber Konstantinos Arfanakis Diane M Becker David Ames Aaron L Goldman Phil H Lee Dorret I Boomsma Simon Lovestone Sudheer Giddaluru Stephanie Le Hellard Manuel Mattheisen Marc M Bohlken Dalia Kasperaviciute Lianne Schmaal Stephen M Lawrie Ingrid Agartz Esther Walton Diana Tordesillas-Gutierrez Gareth E Davies Jean Shin Jonathan C Ipser Louis N Vinke Martine Hoogman Tianye Jia Ralph Burkhardt Marieke Klein Fabrice Crivello Deborah Janowitz Owen Carmichael Unn K Haukvik Benjamin S Aribisala Helena Schmidt Lachlan T Strike Ching-Yu Cheng Shannon L Risacher Benno Pütz Debra A Fleischman Amelia A Assareh Venkata S Mattay Randy L Buckner Patrizia Mecocci Anders M Dale Sven Cichon Marco P Boks Mar Matarin Brenda W J H Penninx Vince D Calhoun M Mallar Chakravarty Andre F Marquand Christine Macare Shahrzad Kharabian Masouleh Jaap Oosterlaan Philippe Amouyel Katrin Hegenscheid Jerome I Rotter Andrew J Schork David C M Liewald Greig I de Zubicaray Tien Yin Wong Li Shen Philipp G Sämann Henry Brodaty Joshua L Roffman Eco J C de Geus Magda Tsolaki Susanne Erk Kristel R van Eijk Gianpiero L Cavalleri Nic J A van der Wee Andrew M McIntosh Randy L Gollub Kazima B Bulayeva Manon Bernard Jennifer S Richards Jayandra J Himali Markus Loeffler Nanda Rommelse Wolfgang Hoffmann Lars T Westlye Maria C Valdés Hernández Narelle K Hansell Theo G M van Erp Christiane Wolf John B J Kwok Bruno Vellas Andreas Heinz Loes M Olde Loohuis Norman Delanty Beng-Choon Ho Christopher R K Ching Elena Shumskaya Baljeet Singh Albert Hofman Dennis van der Meer Georg Homuth Bruce M Psaty Mark E Bastin Grant W Montgomery Tatiana M Foroud Simone Reppermund Jouke-Jan Hottenga Andrew Simmons Andreas Meyer-Lindenberg Wiepke Cahn Christopher D Whelan Marjolein M J van Donkelaar Qiong Yang Norbert Hosten Robert C Green Anbupalam Thalamuthu Sebastian Mohnke Hilleke E Hulshoff Pol Honghuang Lin Clifford R Jack Peter R Schofield Thomas W Mühleisen Pauline Maillard Steven G Potkin Wei Wen Evan Fletcher Arthur W Toga Oliver Gruber Matthew Huentelman George Davey Smith Lenore J Launer Lars Nyberg Erik G Jönsson Benedicto Crespo-Facorro Nastassja Koen Douglas N Greve André G Uitterlinden Daniel R Weinberger Vidar M Steen Iryna O Fedko Nynke A Groenewold Wiro J Niessen Roberto Toro Christophe Tzourio William T Longstreth M Kamran Ikram Jordan W Smoller Marie-Jose van Tol Jessika E Sussmann Tomas Paus Hervé Lemaître Matthias L Schroeter Bernard Mazoyer Ole A Andreassen Florian Holsboer Chantal Depondt Dick J Veltman Jessica A Turner Zdenka Pausova Gunter Schumann Daan van Rooij Srdjan Djurovic Ian J Deary Katie L McMahon Bertram Müller-Myhsok Rachel M Brouwer Hilkka Soininen Massimo Pandolfo Thomas H Wassink Joshua W Cheung Thomas Wolfers Jean-Luc Martinot Marcel P Zwiers Matthias Nauck Ingrid Melle Nicholas G Martin Ryota Kanai Eric Westman René S Kahn Sanjay M Sisodiya Tonya White Arvin Saremi Hans van Bokhoven Han G Brunner Henry Völzke Margaret J Wright Dennis van 't Ent Markus M Nöthen Roel A Ophoff Jan K Buitelaar Guillén Fernández Perminder S Sachdev Marcella Rietschel Neeltje E M van Haren Simon E Fisher Alexa S Beiser Clyde Francks Andrew J Saykin Karen A Mather Nina Romanczuk-Seiferth Catharina A Hartman Anita L DeStefano Dirk J Heslenfeld Michael W Weiner Henrik Walter Pieter J Hoekstra Paul A Nyquist Barbara Franke David A Bennett Hans J Grabe Andrew D Johnson Christopher Chen Cornelia M van Duijn Oscar L Lopez Myriam Fornage Joanna M Wardlaw Reinhold Schmidt Charles DeCarli Philip L De Jager Arno Villringer Stéphanie Debette Vilmundur Gudnason Sarah E Medland Joshua M Shulman Paul M Thompson Sudha Seshadri M Arfan Ikram

Nat Genet 2019 Nov 21;51(11):1624-1636. Epub 2019 Oct 21.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41588-019-0511-yDOI Listing
November 2019

Predictors of Lesion Cavitation After Recent Small Subcortical Stroke.

Transl Stroke Res 2019 Nov 8. Epub 2019 Nov 8.

Centre for Clinical Brain Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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http://dx.doi.org/10.1007/s12975-019-00741-8DOI Listing
November 2019

Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative.

J Cereb Blood Flow Metab 2019 Nov 20:271678X19888967. Epub 2019 Nov 20.

Department of Neurology and Referral Center for Rare Vascular Diseases of the Brain and Retina (CERVCO), APHP, Lariboisière Hospital, Paris, DHU NeuroVasc, Univ Paris Diderot, and U1141 INSERM, France.

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http://dx.doi.org/10.1177/0271678X19888967DOI Listing
November 2019

Mechanical thrombectomy in patients with acute ischemic stroke: A cost-effectiveness and value of implementation analysis.

Int J Stroke 2019 Sep 30:1747493019879656. Epub 2019 Sep 30.

Institute of Neuroscience & Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.

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http://dx.doi.org/10.1177/1747493019879656DOI Listing
September 2019

White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed.

Neurobiol Aging 2019 Sep 27. Epub 2019 Sep 27.

Department of Radiology & Nuclear Medicine, Maastricht University Medical Centre, School for Mental Health & Neuroscience, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.09.017DOI Listing
September 2019

The Glymphatic System and Waste Clearance with Brain Aging: A Review.

Gerontology 2019 11;65(2):106-119. Epub 2018 Jul 11.

Brain Research Imaging Centre, Centre for Clinical Brain Sciences, Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1159/000490349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329683PMC
August 2019

Neurological Disease in Lupus: Toward a Personalized Medicine Approach.

Front Immunol 2018 6;9:1146. Epub 2018 Jun 6.

MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.01146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997834PMC
July 2019

Small vessel disease: mechanisms and clinical implications.

Lancet Neurol 2019 Jul 13;18(7):684-696. Epub 2019 May 13.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany; German Center for Neurodegenerative Diseases, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S14744422193007
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http://dx.doi.org/10.1016/S1474-4422(19)30079-1DOI Listing
July 2019

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Authors:
Duncan Wilson Gareth Ambler Keon-Joo Lee Jae-Sung Lim Masayuki Shiozawa Masatoshi Koga Linxin Li Caroline Lovelock Hugues Chabriat Michael Hennerici Yuen Kwun Wong Henry Ka Fung Mak Luis Prats-Sánchez Alejandro Martínez-Domeño Shigeru Inamura Kazuhisa Yoshifuji Ethem Murat Arsava Solveig Horstmann Jan Purrucker Bonnie Yin Ka Lam Adrian Wong Young Dae Kim Tae-Jin Song Maarten Schrooten Robin Lemmens Sebastian Eppinger Thomas Gattringer Ender Uysal Zeynep Tanriverdi Natan M Bornstein Einor Ben Assayag Hen Hallevi Jun Tanaka Hideo Hara Shelagh B Coutts Lisa Hert Alexandros Polymeris David J Seiffge Philippe Lyrer Ale Algra Jaap Kappelle Rustam Al-Shahi Salman Hans R Jäger Gregory Y H Lip Heinrich P Mattle Leonidas D Panos Jean-Louis Mas Laurence Legrand Christopher Karayiannis Thanh Phan Sarah Gunkel Nicolas Christ Jill Abrigo Thomas Leung Winnie Chu Francesca Chappell Stephen Makin Derek Hayden David J Williams M Eline Kooi Dianne H K van Dam-Nolen Carmen Barbato Simone Browning Kim Wiegertjes Anil M Tuladhar Noortje Maaijwee Christine Guevarra Chathuri Yatawara Anne-Marie Mendyk Christine Delmaire Sebastian Köhler Robert van Oostenbrugge Ying Zhou Chao Xu Saima Hilal Bibek Gyanwali Christopher Chen Min Lou Julie Staals Régis Bordet Nagaendran Kandiah Frank-Erik de Leeuw Robert Simister Aad van der Lugt Peter J Kelly Joanna M Wardlaw Yannie Soo Felix Fluri Velandai Srikanth David Calvet Simon Jung Vincent I H Kwa Stefan T Engelter Nils Peters Eric E Smith Yusuke Yakushiji Dilek Necioglu Orken Franz Fazekas Vincent Thijs Ji Hoe Heo Vincent Mok Roland Veltkamp Hakan Ay Toshio Imaizumi Beatriz Gomez-Anson Kui Kai Lau Eric Jouvent Peter M Rothwell Kazunori Toyoda Hee-Joon Bae Joan Marti-Fabregas David J Werring

Lancet Neurol 2019 Jul 23;18(7):653-665. Epub 2019 May 23.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14744422193019
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http://dx.doi.org/10.1016/S1474-4422(19)30197-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562236PMC
July 2019

Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life.

Front Psychiatry 2019 26;10:524. Epub 2019 Jul 26.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.3389/fpsyt.2019.00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676305PMC
July 2019

Sleep and brain morphological changes in the eighth decade of life.

Sleep Med 2019 Jul 24. Epub 2019 Jul 24.

Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE), UK; UK Dementia Research Institute, University of Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2019.07.015DOI Listing
July 2019

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis.

Int J Stroke 2019 06 14;14(4):359-371. Epub 2019 Feb 14.

1 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1177/1747493019830321DOI Listing
June 2019

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.

Alzheimers Dement 2019 Jun 25;15(6):840-858. Epub 2019 Apr 25.

Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK; Dementia Research Institute, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1016/j.jalz.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565805PMC
June 2019

Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition.

Brain Imaging Behav 2019 Jun 27. Epub 2019 Jun 27.

Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, 49 Little France Crescent, Chancellor's Building, Edinburgh, EH16 4SB, UK.

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http://dx.doi.org/10.1007/s11682-019-00128-1DOI Listing
June 2019

Percutaneous Vascular Interventions Versus Intravenous Thrombolytic Treatment for Acute Ischemic Stroke.

Stroke 2019 May;50(5):e119-e120

Department of Internal Medicine, Oslo University Hospital, Norway (K.M.H.B.S., E.B.).

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http://dx.doi.org/10.1161/STROKEAHA.118.024298DOI Listing
May 2019

Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke.

Stroke 2019 May;50(5):1136-1139

From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, United Kingdom (A.W., J.D., D.A.D.).

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http://dx.doi.org/10.1161/STROKEAHA.118.024181DOI Listing
May 2019

Cortical thickness, white matter hyperintensities, and cognition after stroke.

Int J Stroke 2019 May 14:1747493019851291. Epub 2019 May 14.

1 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.

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http://dx.doi.org/10.1177/1747493019851291DOI Listing
May 2019

Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability.

Brain Sci 2019 May 22;9(5). Epub 2019 May 22.

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, Edinburgh Bioquarter, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

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http://dx.doi.org/10.3390/brainsci9050117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562568PMC
May 2019

Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke.

J Neurol Neurosurg Psychiatry 2019 Apr 15;90(4):436-443. Epub 2018 Dec 15.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

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http://dx.doi.org/10.1136/jnnp-2018-319134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581154PMC
April 2019

WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.

Neurology 2019 Mar 15;92(12):e1298-e1308. Epub 2019 Feb 15.

From the Institute for Stroke and Dementia Research, University Hospital (M.K.G., M. Duering, M. Dichgans), and Graduate School for Systemic Neurosciences (M.K.G.), Ludwig-Maximilians-Universität LMU, Munich, Germany; Division of Neuroimaging Science (J.M.W.), Centre for Clinical Brain Science, Edinburgh Imaging and UK Dementia Research Institute, University of Edinburgh, UK; Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans); and German Centre for Neurodegenerative Diseases (M. Dichgans), Munich, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007142DOI Listing
March 2019

A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic and clinical features.

Sci Rep 2019 Mar 5;9(1):3591. Epub 2019 Mar 5.

VAMPIRE project, Computer Vision and Image Processing Group, School of Science and Engineering (Computing), University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1038/s41598-019-40403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401035PMC
March 2019

Stroke research in 2018: extended time windows, refined benefit, and lifestyle prevention targets.

Lancet Neurol 2019 Jan;18(1):2-3

Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital, Nottingham, UK.

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http://dx.doi.org/10.1016/S1474-4422(18)30457-5DOI Listing
January 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Manually-parcellated gyral data accounting for all known anatomical variability.

Sci Data 2019 01 29;6:190001. Epub 2019 Jan 29.

University of Edinburgh, Centre for Clinical Brain Sciences (CCBS), The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

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http://dx.doi.org/10.1038/sdata.2019.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350632PMC
January 2019

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

Effect of IV alteplase on the ischemic brain lesion at 24-48 hours after ischemic stroke.

Neurology 2018 11 26;91(22):e2067-e2077. Epub 2018 Oct 26.

From Edinburgh Imaging, and UK Dementia Research Institute at the University of Edinburgh and Centre for Clinical Brain Sciences (G.M., Z.M., A.J.F., J.M.W.), and Division of Clinical Neurosciences (P.A.G.S.), University of Edinburgh, UK; Department of Neuroradiology (R.v.K.), Dresden University Stroke Centre, Germany; Danderyd Hospital (A.v.H.), Stockholm, Sweden; Neuroradiology (N.B.), James Cook University Hospital, Middlesborough, UK; School of Medicine (L.C.), University of Western Australia; Cliniques Universitaires St Luc (A.P.), Neurologie, Belgium; Stroke Center (A.A.), Department of Neurology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy; Department of Neuroradiology (G.P.), Salford Royal NHS Foundation Trust, Manchester, UK; and Westmead Hospital Clinical School and The George Institute for Global Health (R.I.L.), University of Sydney, Australia.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282236PMC
November 2018

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury.

Int J Stroke 2018 10 19;13(8):849-856. Epub 2018 Apr 19.

2 Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, University of Glasgow, Glasgow, UK.

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http://journals.sagepub.com/doi/10.1177/1747493018770222
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http://dx.doi.org/10.1177/1747493018770222DOI Listing
October 2018

Association between carotid atheroma and cerebral cortex structure at age 73 years.

Ann Neurol 2018 10 5;84(4):576-587. Epub 2018 Oct 5.

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/ana.25324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328248PMC
October 2018

Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow.

J Cereb Blood Flow Metab 2018 Oct 8:271678X18803956. Epub 2018 Oct 8.

3 Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1177/0271678X18803956DOI Listing
October 2018

Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology.

J Int Med Res 2018 Sep 26;46(9):3518-3538. Epub 2018 Mar 26.

2 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1177/0300060518755623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135998PMC
September 2018

Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.

Neurobiol Aging 2018 09 31;69:274-282. Epub 2018 May 31.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK; Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075468PMC
September 2018

Reproducibility of Transcranial Doppler ultrasound in the middle cerebral artery.

Cardiovasc Ultrasound 2018 Sep 11;16(1):15. Epub 2018 Sep 11.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SA, UK.

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http://dx.doi.org/10.1186/s12947-018-0133-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131943PMC
September 2018

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Nat Commun 2018 09 26;9(1):3945. Epub 2018 Sep 26.

The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-06234-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214PMC
September 2018

Widespread associations between trait conscientiousness and thickness of brain cortical regions.

Neuroimage 2018 08 14;176:22-28. Epub 2018 Apr 14.

Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2018.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986708PMC
August 2018

Rapid Automated Quantification of Cerebral Leukoaraiosis on CT Images: A Multicenter Validation Study.

Radiology 2018 08 15;288(2):573-581. Epub 2018 May 15.

From the Biomedical Imaging Analysis Group, Computer Science (L.C., D.R.), and Division of Brain Sciences (L.C., A.L.C.J., A.G., J.G., N.M., A.D., B.A., A.M., P.B.), Imperial College London, Charing Cross Hospital, Fulham Palace Rd, 10L21, London W6 8RF, England; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland (G.M., J.W.); and Department of Radiology, Northwick Park Hospital, London North West Healthcare NHS Trust, London, England (R.P., D.C.).

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http://pubs.rsna.org/doi/10.1148/radiol.2018171567
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http://dx.doi.org/10.1148/radiol.2018171567DOI Listing
August 2018

Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Stroke 2018 08;49(8):1812-1819

From the Institute of Molecular Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (M.F., X.J.).

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http://dx.doi.org/10.1161/STROKEAHA.118.020689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202149PMC
August 2018

Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging.

J Stroke Cerebrovasc Dis 2018 Jul 23;27(7):1815-1821. Epub 2018 Mar 23.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183007
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013276PMC
July 2018

William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable.

Authors:
Joanna M Wardlaw

Stroke 2018 07 12;49(7):1770-1775. Epub 2018 Jun 12.

From the Division of Neuroimaging Science, Centre for Clinical Brain Science, Edinburgh Imaging and UK Dementia Research Institute at the University of Edinburgh.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.021184
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http://dx.doi.org/10.1161/STROKEAHA.118.021184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027992PMC
July 2018

Response by Loos et al to Letter Regarding Article, "Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging".

Stroke 2018 07 18;49(7):e269. Epub 2018 Jun 18.

Neuroimaging Sciences, Centre for Clinical Brain Sciences, Brain Research Imaging Centre, UK Dementia Research Institute, University of Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.118.021876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022809PMC
July 2018

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats.

Sci Transl Med 2018 07;10(448)

Medical Research Council (MRC) Centre for Regenerative Medicine and UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4UU, UK.

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http://dx.doi.org/10.1126/scitranslmed.aam9507DOI Listing
July 2018

Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease.

Clin Sci (Lond) 2018 06 26;132(12):1315-1328. Epub 2018 Jun 26.

Centre for Clinical Brain Sciences, and UK Dementia Research Institute at the University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh EH16 4SB, U.K.

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http://dx.doi.org/10.1042/CS20171572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365623PMC
June 2018

The impact of early-life intelligence quotient on post stroke cognitive impairment.

Eur Stroke J 2018 Jun 8;3(2):145-156. Epub 2018 Jan 8.

3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh.

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http://dx.doi.org/10.1177/2396987317750517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460404PMC
June 2018

Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging.

Stroke 2018 05 22;49(5):1183-1188. Epub 2018 Mar 22.

Brain Research Imaging Centre, Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Scotland, United Kingdom (S.D.J.M., M.S.D., J.M.W.)

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http://dx.doi.org/10.1161/STROKEAHA.117.020495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916475PMC
May 2018

Perivascular Spaces Segmentation in Brain MRI Using Optimal 3D Filtering.

Sci Rep 2018 02 1;8(1):2132. Epub 2018 Feb 1.

Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Centre for Cognitive Ageing and Cognitive Epidemiology and UK Dementia Research Institute Edinburgh Dementia Research Centre, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41598-018-19781-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794857PMC
February 2018

Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review.

Clin Sci (Lond) 2018 01 16;132(1):157-171. Epub 2018 Jan 16.

Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.

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http://dx.doi.org/10.1042/CS20171280DOI Listing
January 2018