Publications





Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor.
Transl Oncol 2017 Dec 22;10(6):895-903. Epub 2017 Sep 22.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.

Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression.
Acta Neuropathol 2017 Dec 23;134(6):961-963. Epub 2017 Oct 23.
Division of Neuropathology, Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Health Sciences West 451, Box 0102, San Francisco, CA, 94143, USA.




Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Cancer Cell 2017 Jul;32(1):42-56.e6
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address:

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
Cancer Cell 2017 Mar;31(3):424-435
Department of Neurology, University of California, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, CA 94158, USA. Electronic address:

Safety Study: Intraventricular Injection of a Modified Oncolytic Measles Virus into Measles-Immune, hCD46-Transgenic, IFNαRko Mice.
Hum Gene Ther Clin Dev 2016 Dec 7;27(4):145-151. Epub 2016 Sep 7.
1 Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California , San Francisco, San Francisco, California.

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.
Nat Cell Biol 2016 Dec 7;18(12):1336-1345. Epub 2016 Nov 7.
Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA.



Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence.
J Neuropathol Exp Neurol 2016 Oct 18;75(10):925-935. Epub 2016 Aug 18.
From the Division of Neuropathology, Department of Pathology (MDW, GFR, JJP) and Department of Neurological Surgery (JJP), University of California San Francisco, San Francisco, California; and Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany (DER).

The Development of Reduced Diffusion Following Bevacizumab Therapy Identifies Regions of Recurrent Disease in Patients with High-grade Glioma.
Acad Radiol 2016 Sep 18;23(9):1073-82. Epub 2016 Jul 18.
Department of Radiology and Biomedical Imaging, Neuroradiology Section, University of California, Box 0628 Bldg 350 Parnassus Ave, Room 307, San Francisco, CA 94143; Department of Neurological Surgery, University of California, San Francisco, California. Electronic address:


New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
Cell 2016 Feb;164(5):1060-1072
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells.
Cancer Res 2015 Dec 16;75(24):5355-66. Epub 2015 Nov 16.
Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California. Helen Diller Comprehensive Cancer Research Center, University of California San Francisco, San Francisco, California. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, University of California San Francisco, San Francisco, California.


Toward precision medicine in glioblastoma: the promise and the challenges.
Neuro Oncol 2015 Aug 1;17(8):1051-63. Epub 2015 May 1.
University of California San Francisco, San Francisco, California (M.D.P, J.J.P., A.M.M., S.M.C.); Translational Genomics Research Institute, Phoenix, Arizona (S.A.B., N.L.T., W.D.T., J.A.K., M.E.B., D.W.C., J.D.C., J.M.T.); Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (K.L.L., P.Y.W.); University of Texas Health Science Center, San Antonio, Texas (J.G.K.); Memorial Sloan-Kettering Cancer Center, New York, New York (I.K.M.); The University of Texas M.D. Anderson Cancer Center, Houston, Texas (J.F.d.G.); University of Utah Huntsman Cancer Institute, Salt Lake City, Utah (H.C.); University of California Los Angeles, Los Angeles, California (T.F.C.); Iowa Spine and Brain Institute, Waterloo, Iowa (T.C.R.).

CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
J Neuropathol Exp Neurol 2015 May;74(5):442-52
From the Departments of Neurology, Pediatrics, and Neurosurgery, Stanford University School of Medicine, Stanford (HV); Department of Anatomic Pathology, University of California San Francisco Medical School (GFR, MP, AP); Division of Neuroepidemiology (HMH, TR, JKW, MRW, KMW), Departments of Neurological Surgery (REM, AMM, JJP, AP) and Epidemiology and Biostatistics (AMM); and Institute for Human Genetics, University of California San Francisco (JKW, MRW, KMW), San Francisco, California.

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.
Acta Neuropathol 2014 Nov 9;128(5):743-53. Epub 2014 Sep 9.
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, 10065, USA,

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma.
Cancer Res 2014 Aug 29;74(16):4247-57. Epub 2014 May 29.
Departments of Radiology and Biomedical Imaging, Brain Tumor Research Center, University of California San Francisco, San Francisco, California

Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy.
NMR Biomed 2014 May 5;27(5):578-93. Epub 2014 Mar 5.
University of California, Berkeley and University of California, San Francisco Graduate Program in Bioengineering, University of California, Berkeley/San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA.

Cytogenetic prognostication within medulloblastoma subgroups.
J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.
David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

Frequent truncating mutations of STAG2 in bladder cancer.
Nat Genet 2013 Dec 13;45(12):1428-30. Epub 2013 Oct 13.
1] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA. [2] Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.
Mod Pathol 2013 Nov 14;26(11):1425-32. Epub 2013 Jun 14.
1] Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA [2] Division of Surgical Pathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells.
Neuro Oncol 2013 Nov 25;15(11):1518-31. Epub 2013 Jul 25.
Corresponding Author: Andrew T. Parsa, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave., San Francisco, CA 94117.


Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.
Magn Reson Med 2013 Jul 31;70(1):33-9. Epub 2012 Jul 31.
Department of Radiology and Biomedical Imaging, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, California, USA.


Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment.
J Neurooncol 2012 Dec 17;110(3):305-13. Epub 2012 Sep 17.
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143-0520, USA.

Epigenetic biomarkers of T-cells in human glioma.
Epigenetics 2012 Dec 29;7(12):1391-402. Epub 2012 Oct 29.
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA USA.



Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.
Cancer Cell 2012 May;21(5):601-13
University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA.

Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype.
J Neuropathol Exp Neurol 2012 Jan;71(1):83-9
Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA.


Metabolic reprogramming in mutant IDH1 glioma cells.
PLoS One 2015 23;10(2):e0118781. Epub 2015 Feb 23.
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America; Brain Tumor Research Center, University of California San Francisco, San Francisco, California, United States of America.


MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.
Mol Cancer Ther 2016 05 16;15(5):1113-22. Epub 2016 Feb 16.
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California. Brain Tumor Research Center, University of California San Francisco, San Francisco, California.

Magnetic resonance analysis of malignant transformation in recurrent glioma.
Neuro Oncol 2016 08 23;18(8):1169-79. Epub 2016 Feb 23.
Joint Graduate Program in Bioengineering (L.E.J., S.J.N.), Department of Radiology & Biomedical Imaging (E.N., J.M.L., M.P.O., S.J.N.), Department of Pathology (J.J.P.), Department of Neurological Surgery (J.J.P., A.M.M., M.S.B., S.M.C.), Department of Biostatistics and Epidemiology (A.M.M.),  University of California, San Francisco, San Francisco, California.


Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma.
J Neurooncol 2016 12 13;130(3):543-552. Epub 2016 Sep 13.
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, M-779, San Francisco, CA, 94143, USA.

Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation.
Acta Neuropathol 2016 11 13;132(5):757-760. Epub 2016 Sep 13.
Division of Medical Genetics, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.





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