Joanna D Holbrook

Joanna D Holbrook

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Joanna D Holbrook

Publications by authors named "Joanna D Holbrook"

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Epigenetic Age Acceleration in Adolescence Associates With BMI, Inflammation, and Risk Score for Middle Age Cardiovascular Disease.

J Clin Endocrinol Metab 2019 Jul;104(7):3012-3024

Curtin/UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia.

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http://dx.doi.org/10.1210/jc.2018-02076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555851PMC
July 2019

The role of ethnicity and socioeconomic status in Southeast Asian mothers' parenting sensitivity.

Attach Hum Dev 2018 Feb 25;20(1):24-42. Epub 2017 Aug 25.

a Brenner Centre for Molecular Medicine , Singapore Institute for Clinical Sciences (SICS), Agency for Science and Technology (A*STAR) , Singapore , Singapore.

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http://dx.doi.org/10.1080/14616734.2017.1365912DOI Listing
February 2018

Vitamin B supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits.

Epigenomics 2018 01 14;10(1):71-90. Epub 2017 Nov 14.

Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular & Molecular Biology, Hyderabad, Telangana, 500 007, India.

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http://dx.doi.org/10.2217/epi-2017-0102DOI Listing
January 2018

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

Transl Psychiatry 2018 01 10;8(1):15. Epub 2018 Jan 10.

The Ludmer Centre for Neuroinformatics and Mental Health, Douglas Hospital Research Centre and Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, QC, H4H1R3, Canada.

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http://dx.doi.org/10.1038/s41398-017-0063-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802588PMC
January 2018

Is cellular heterogeneity merely a confounder to be removed from epigenome-wide association studies?

Epigenomics 2017 08 27;9(8):1143-1150. Epub 2017 Jul 27.

Human Development & Health Academic Unit, University of Southampton & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.2217/epi-2017-0032DOI Listing
August 2017

ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity.

EBioMedicine 2017 May 26;19:60-72. Epub 2017 Apr 26.

NIHR Southampton Biomedical Research Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1016/j.ebiom.2017.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440605PMC
May 2017

Predicting functional decline and survival in amyotrophic lateral sclerosis.

PLoS One 2017 13;12(4):e0174925. Epub 2017 Apr 13.

Singapore Institute for Clinical Sciences (SICS), Agency of Science and Technology Research (A*STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174925PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390993PMC
April 2017

Catching diabetes.

Epigenomics 2016 09 16;8(9):1173-7. Epub 2016 Aug 16.

NIHR Southampton Biomedical Research Centre, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.2217/epi-2016-0079DOI Listing
September 2016

How to make DNA methylome wide association studies more powerful.

Epigenomics 2016 08 7;8(8):1117-29. Epub 2016 Apr 7.

Singapore Institute for Clinical Sciences (SICS), Agency for Science & Technology Research (A*STAR), Brenner Centre for Molecular Medicine, 30 Medical Drive, 117609, Singapore.

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http://dx.doi.org/10.2217/epi-2016-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066141PMC
August 2016

Gene, Environment and Methylation (GEM): a tool suite to efficiently navigate large scale epigenome wide association studies and integrate genotype and interaction between genotype and environment.

BMC Bioinformatics 2016 Aug 2;17:299. Epub 2016 Aug 2.

School of Computer Science and Engineering, Nanyang Technological University (NTU), Singapore, 639798, Singapore.

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http://dx.doi.org/10.1186/s12859-016-1161-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970299PMC
August 2016

Does diet interact with genotype to cause epigenetic modification of angiogenesis genes, on the trajectory to obesity?

Epigenomics 2016 06 24;8(6):741-5. Epub 2016 Mar 24.

Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore, 119521.

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http://dx.doi.org/10.2217/epi-2016-0023DOI Listing
June 2016

ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.

J Natl Cancer Inst 2016 Feb 7;108(2). Epub 2015 Nov 7.

Department of Research (YKC, ES, LWHK, MT, MSYT, GRHK, TBT, GGYL, KLL, CT), Department of Neuroradiology (MN), and Department of Neurosurgery (IN, WHN, BTA), National Neuroscience Institute, Singapore; Department of Physiology (YKC, KLL, BTA) and Department of Biochemistry (OLK), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences (ES, JDH, BTA) and Institute of Molecular and Cell Biology (NST), Agency for Science, Technology and Research (A*STAR), Singapore; School of Biological Sciences, Nanyang Technological University, Singapore (ES, LWHK, MSYT, NST); Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore (OLK, CT); Duke-National University of Singapore Graduate Medical School, Singapore (IN, WHN, KLL, CT, BTA).

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http://dx.doi.org/10.1093/jnci/djv326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755447PMC
February 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

Ethnic Differences in Effects of Maternal Pre-Pregnancy and Pregnancy Adiposity on Offspring Size and Adiposity.

J Clin Endocrinol Metab 2015 Oct 22;100(10):3641-50. Epub 2015 Jul 22.

Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (X.L., P.D.G., Y.S.C., J.D.H., Y.S.L.), 117609 Singapore; Department of Paediatrics (I.M.A., S.E.S., Y.S.L.), Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore; Department of Obstetrics and Gynaecology (M.T.T., Y.S.C.), Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore; Saw Swee Hock School of Public Health (S.E.S.), National University of Singapore, 117597 Singapore; MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre (K.M.G.), University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD United Kingdom; Department of Maternal Fetal Medicine (G.S.-H.Y., K.K.), KK Women's and Children's Hospital, 229899 Singapore; Department of Reproductive Medicine (J.K.-Y.C.), KK Women's and Children's Hospital, 229899 Singapore; Centre for Human Evolution, Adaptation and Disease (P.D.G.), Liggins Institute, University of Auckland, Auckland, New Zealand; Department of Paediatrics (F.Y.), KK Women's and Children's Hospital, 229899 Singapore; Department of Biochemistry (J.D.H.), National University of Singapore, 117596 Singapore; and Division of Paediatric Endocrinology and Diabetes (Y.S.L.), Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, 119228 Singapore.

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http://dx.doi.org/10.1210/jc.2015-1728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628100PMC
October 2015

Insights from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort study.

Ann Nutr Metab 2014 2;64(3-4):218-25. Epub 2014 Oct 2.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1159/000365023DOI Listing
June 2015

ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content.

Mol Endocrinol 2015 Jun 27;29(6):909-20. Epub 2015 Apr 27.

Singapore Institute for Clinical Sciences (R.J., R.S., P.G.T., S.G.J., F.X., A.L.T., J.D.H., Y.S.C., P.D.G., W.S.), Agency for Science, Technology and Research, Singapore 117609; Genome Institute of Singapore (J.P., S.P.), Agency for Science, Technology and Research, Singapore 138672; Department of Obstetrics and Gynaecology (K.L.N., Y.S.C.), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228; and Liggins Institute (P.D.G.), University of Auckland, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1210/me.2015-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414735PMC
June 2015

An epigenetic escape route.

Trends Genet 2015 Jan;31(1):2-4

Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, 117609; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 119228. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.09.007DOI Listing
January 2015

Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells.

Hum Reprod 2014 Oct 16;29(10):2287-301. Epub 2014 Aug 16.

Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore

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http://dx.doi.org/10.1093/humrep/deu209DOI Listing
October 2014

Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study.

BMC Pregnancy Childbirth 2014 Oct 2;14:345. Epub 2014 Oct 2.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Singapore 119228, Singapore.

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http://dx.doi.org/10.1186/1471-2393-14-345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190487PMC
October 2014

Alterations to DNA methylation and expression of CXCL14 are associated with suboptimal birth outcomes.

J Hum Genet 2014 Sep 7;59(9):504-11. Epub 2014 Aug 7.

Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1038/jhg.2014.63DOI Listing
September 2014

Global DNA hypermethylation in down syndrome placenta.

PLoS Genet 2013 Jun 6;9(6):e1003515. Epub 2013 Jun 6.

Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.1371/journal.pgen.1003515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675012PMC
June 2013

The translational value of rodent gastrointestinal functions: a cautionary tale.

Trends Pharmacol Sci 2011 Jul 29;32(7):402-9. Epub 2011 Apr 29.

Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.

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http://dx.doi.org/10.1016/j.tips.2011.03.009DOI Listing
July 2011

Molecular evolutionary analysis of cancer cell lines.

Mol Cancer Ther 2010 Feb 2;9(2):279-91. Epub 2010 Feb 2.

Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA.

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http://mct.aacrjournals.org/content/early/2010/02/01/1535-71
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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-09
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http://dx.doi.org/10.1158/1535-7163.MCT-09-0508DOI Listing
February 2010

Drug discovery and computational evolutionary analysis.

Drug Discov Today 2007 Oct 27;12(19-20):826-32. Epub 2007 Sep 27.

GlaxoSmithKline, Molecular Discovery Research, Bioinformatics Analysis, Stevenage SG1 2NY, United Kingdom.

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http://dx.doi.org/10.1016/j.drudis.2007.08.015DOI Listing
October 2007

New methods for researching accessory proteins.

J Mol Neurosci 2005 ;26(2-3):265-76

Bioinformatics, GlaxoSmithKline, Stevenage, Herts SG1 2NY, UK.

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http://dx.doi.org/10.1385/JMN:26:2-3:265DOI Listing
October 2005

Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.

J Immunol 2004 Aug;173(4):2562-70

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.173.4.2562DOI Listing
August 2004

Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.

Biochem Biophys Res Commun 2003 Jan;300(2):472-6

Department of Atherosclerosis, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, UK.

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http://dx.doi.org/10.1016/s0006-291x(02)02841-3DOI Listing
January 2003

Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells.

J Biol Chem 2002 Jan 2;277(3):2336-44. Epub 2001 Nov 2.

Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M107047200DOI Listing
January 2002