Joan Massagué

Joan Massagué

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Joan Massagué

Publications by authors named "Joan Massagué"

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H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling.

Stem Cell Reports 2019 Oct 26;13(4):642-656. Epub 2019 Sep 26.

MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; Joint Graduate Program of Peking-Tsinghua-NIBS, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830056PMC
October 2019

Transforming Growth Factor-β Signaling in Immunity and Cancer.

Immunity 2019 04;50(4):924-940

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
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http://dx.doi.org/10.1016/j.immuni.2019.03.024DOI Listing
April 2019

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization.

Elife 2019 03 26;8. Epub 2019 Mar 26.

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.7554/eLife.43627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440742PMC
March 2019

Contextual determinants of TGFβ action in development, immunity and cancer.

Nat Rev Mol Cell Biol 2018 07;19(7):419-435

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41580-018-0007-0DOI Listing
July 2018

Publisher Correction: Contextual determinants of TGFβ action in development, immunity and cancer.

Nat Rev Mol Cell Biol 2018 Jul;19(7):479

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41580-018-0018-xDOI Listing
July 2018

TGF-β Inhibition and Immunotherapy: Checkmate.

Immunity 2018 04;48(4):626-628

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183013
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http://dx.doi.org/10.1016/j.immuni.2018.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347120PMC
April 2018

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.

Nat Commun 2017 12 12;8(1):2070. Epub 2017 Dec 12.

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41467-017-02054-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727232PMC
December 2017

Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.

Cell 2017 03;168(6):1101-1113.e13

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405733PMC
March 2017

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.

Cell Stem Cell 2017 01 23;20(1):70-86. Epub 2016 Nov 23.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218926PMC
January 2017

Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases.

Nanoscale 2017 Jan;9(3):1110-1119

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. and Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA and Department of Radiology, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1039/c6nr08217cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438878PMC
January 2017

Understanding the molecular mechanisms driving metastasis.

Mol Oncol 2017 01;11(1):3-4

Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Spain.

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http://doi.wiley.com/10.1002/1878-0261.12024
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http://dx.doi.org/10.1002/1878-0261.12024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423223PMC
January 2017

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.

Nature 2016 05 18;533(7604):493-498. Epub 2016 May 18.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/nature18268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021195PMC
May 2016

Arresting supporters: targeting neutrophils in metastasis.

Cell Res 2016 Mar 29;26(3):273-4. Epub 2016 Jan 29.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2016.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783468PMC
March 2016

TGF-β Tumor Suppression through a Lethal EMT.

Cell 2016 Feb 18;164(5):1015-30. Epub 2016 Feb 18.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801341PMC
February 2016

Metastatic colonization by circulating tumour cells.

Nature 2016 Jan;529(7586):298-306

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.

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http://www.nature.com/articles/nature17038
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http://dx.doi.org/10.1038/nature17038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029466PMC
January 2016

Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.

Cancer Res 2015 Sep 24;75(18):3713-9. Epub 2015 Jul 24.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573898PMC
September 2015

Surviving at a Distance: Organ-Specific Metastasis.

Trends Cancer 2015 Sep 28;1(1):76-91. Epub 2015 Sep 28.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673677PMC
September 2015

Structural determinants of Smad function in TGF-β signaling.

Trends Biochem Sci 2015 Jun 29;40(6):296-308. Epub 2015 Apr 29.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485443PMC
June 2015

Therapy-induced tumour secretomes promote resistance and tumour progression.

Nature 2015 Apr 25;520(7547):368-72. Epub 2015 Mar 25.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature14336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507807PMC
April 2015

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.

Nat Cell Biol 2014 Sep 3;16(9):876-88. Epub 2014 Aug 3.

1] Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [3] Metastasis Research Center, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249762PMC
September 2014

RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation.

EMBO Mol Med 2014 Jul;6(7):865-81

Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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http://dx.doi.org/10.15252/emmm.201303675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119352PMC
July 2014

Metastatic stem cells: sources, niches, and vital pathways.

Cell Stem Cell 2014 Mar;14(3):306-21

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998185PMC
March 2014

Serpins promote cancer cell survival and vascular co-option in brain metastasis.

Cell 2014 Feb;156(5):1002-16

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Metastasis Research Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988473PMC
February 2014

TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition.

Cell Rep 2013 Dec;5(5):1228-42

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 415 East 68(th) Street, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891470PMC
December 2013

Hypoxia signaling--license to metastasize.

Cancer Discov 2013 Oct;3(10):1103-4

1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York; and 2Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889127PMC
October 2013

Origins of metastatic traits.

Cancer Cell 2013 Oct;24(4):410-21

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108130041
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http://dx.doi.org/10.1016/j.ccr.2013.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998120PMC
October 2013

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

Cell 2013 Aug;154(5):1060-1073

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974915PMC
August 2013

Signalling change: signal transduction through the decades.

Nat Rev Mol Cell Biol 2013 Jun 2;14(6):393-8. Epub 2013 May 2.

Friedrich Miescher Institute for Biomedical Research, and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1038/nrm3581DOI Listing
June 2013

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.

Nat Med 2013 Jan 9;19(1):50-6. Epub 2012 Dec 9.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540187PMC
January 2013

Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis.

Clin Cancer Res 2012 Oct 9;18(20):5520-5. Epub 2012 Aug 9.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473104PMC
October 2012

Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.

Structure 2012 Oct 23;20(10):1726-36. Epub 2012 Aug 23.

Structural and Computational Biology Programme, Institute for Research in Biomedicine, Baldiri Reixac 10-12, 08028 Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S096921261200279
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http://dx.doi.org/10.1016/j.str.2012.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472128PMC
October 2012

TGFβ signalling in context.

Authors:
Joan Massagué

Nat Rev Mol Cell Biol 2012 Oct 20;13(10):616-30. Epub 2012 Sep 20.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://www.nature.com/articles/nrm3434
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http://dx.doi.org/10.1038/nrm3434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027049PMC
October 2012

Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer.

J Neurooncol 2012 Sep 14;109(2):229-38. Epub 2012 Jun 14.

Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.

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http://link.springer.com/content/pdf/10.1007/s11060-012-0904
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http://link.springer.com/10.1007/s11060-012-0904-6
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http://dx.doi.org/10.1007/s11060-012-0904-6DOI Listing
September 2012

TGF-β signaling in development and disease.

Authors:
Joan Massagué

FEBS Lett 2012 Jul 28;586(14):1833. Epub 2012 May 28.

Memorial Sloan-Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, NY 10065, USA.

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http://doi.wiley.com/10.1016/j.febslet.2012.05.030
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http://dx.doi.org/10.1016/j.febslet.2012.05.030DOI Listing
July 2012

TGF-β control of stem cell differentiation genes.

FEBS Lett 2012 Jul 10;586(14):1953-8. Epub 2012 Apr 10.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://doi.wiley.com/10.1016/j.febslet.2012.03.023
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http://dx.doi.org/10.1016/j.febslet.2012.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466472PMC
July 2012

Field cancerization: something new under the sun.

Cell 2012 Jun;149(6):1179-81

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2012.05.013DOI Listing
June 2012

Ubiquitin removal in the TGF-β pathway.

Nat Cell Biol 2012 Jun 29;14(7):656-7. Epub 2012 Jun 29.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://www.nature.com/articles/ncb2534
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http://dx.doi.org/10.1038/ncb2534DOI Listing
June 2012

Extracellular matrix players in metastatic niches.

EMBO J 2012 Jan 16;31(2):254-6. Epub 2011 Dec 16.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.469
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http://dx.doi.org/10.1038/emboj.2011.469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261570PMC
January 2012

Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.

Cancer Cell 2011 Oct;20(4):538-49

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293160PMC
October 2011

Breast cancer tumor size, nodal status, and prognosis: biology trumps anatomy.

J Clin Oncol 2011 Jul 23;29(19):2610-2. Epub 2011 May 23.

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http://dx.doi.org/10.1200/JCO.2011.36.1873DOI Listing
July 2011

Clinical implications of cancer self-seeding.

Nat Rev Clin Oncol 2011 Jun 26;8(6):369-77. Epub 2011 Apr 26.

Department of Medicine, Memorial Sloan-Kettering Cancer Center and the Weill College of Medicine of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/nrclinonc.2011.64DOI Listing
June 2011

A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

Genes Dev 2011 Jun;25(12):1275-88

Structural and Computational Biology Programme, Institute for Research in Biomedicine, Barcelona, Spain.

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http://dx.doi.org/10.1101/gad.2060811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127429PMC
June 2011

HER2 silences tumor suppression in breast cancer cells by switching expression of C/EBPß isoforms.

Cancer Res 2010 Dec 23;70(23):9927-36. Epub 2010 Nov 23.

Oncology Programme, Institute for Research in Biomedicine, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0869DOI Listing
December 2010

Modeling metastasis in the mouse.

Curr Opin Pharmacol 2010 Oct 1;10(5):571-7. Epub 2010 Jul 1.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.coph.2010.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952835PMC
October 2010

Tumor self-seeding by circulating cancer cells.

Cell 2009 Dec;139(7):1315-26

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.cell.2009.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810531PMC
December 2009

Multimodality imaging of TGFbeta signaling in breast cancer metastases.

FASEB J 2009 Aug 26;23(8):2662-72. Epub 2009 Mar 26.

Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1096/fj.08-126920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717767PMC
August 2009

ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.

Genes Dev 2009 Aug 16;23(16):1882-94. Epub 2009 Jul 16.

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1101/gad.1824809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725946PMC
August 2009

WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.

Cell 2009 Jul 2;138(1):51-62. Epub 2009 Jul 2.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.cell.2009.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742946PMC
July 2009

Genes that mediate breast cancer metastasis to the brain.

Nature 2009 Jun 6;459(7249):1005-9. Epub 2009 May 6.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature08021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698953PMC
June 2009

Metastasis: from dissemination to organ-specific colonization.

Nat Rev Cancer 2009 Apr;9(4):274-84

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://www.nature.com/articles/nrc2622
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http://dx.doi.org/10.1038/nrc2622DOI Listing
April 2009

Roles of TGFbeta in metastasis.

Cell Res 2009 Jan;19(1):89-102

Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 116, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2008.316DOI Listing
January 2009

Molecular basis of metastasis.

N Engl J Med 2008 Dec;359(26):2814-23

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York 10065, USA.

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http://dx.doi.org/10.1056/NEJMra0805239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189180PMC
December 2008

TGFbeta in Cancer.

Authors:
Joan Massagué

Cell 2008 Jul;134(2):215-30

Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2008.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512574PMC
July 2008

Cell regulation.

Curr Opin Cell Biol 2008 Apr 3;20(2):117-8. Epub 2008 Apr 3.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740800032
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http://dx.doi.org/10.1016/j.ceb.2008.02.006DOI Listing
April 2008

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.

Cell 2008 Apr;133(1):66-77

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.cell.2008.01.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390892PMC
April 2008

A very private TGF-beta receptor embrace.

Authors:
Joan Massagué

Mol Cell 2008 Feb;29(2):149-50

Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650800040
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http://dx.doi.org/10.1016/j.molcel.2008.01.006DOI Listing
February 2008

Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.

J Biol Chem 2008 Jan 14;283(2):1146-55. Epub 2007 Nov 14.

Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707479200
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http://dx.doi.org/10.1074/jbc.M707479200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692279PMC
January 2008

Endogenous human microRNAs that suppress breast cancer metastasis.

Nature 2008 Jan;451(7175):147-52

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782491PMC
January 2008

ID genes mediate tumor reinitiation during breast cancer lung metastasis.

Proc Natl Acad Sci U S A 2007 Dec 28;104(49):19506-11. Epub 2007 Nov 28.

Cancer Biology and Genetics Program, Molecular Cytology Core Facility, Human Oncology and Pathogenesis Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148319PMC
December 2007

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

Nat Chem Biol 2007 Aug 1;3(8):498-507. Epub 2007 Jul 1.

Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nchembio.2007.10DOI Listing
August 2007

Genetic determinants of cancer metastasis.

Nat Rev Genet 2007 May;8(5):341-52

Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Box 116, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, USA.

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May 2007

Lung metastasis genes couple breast tumor size and metastatic spread.

Proc Natl Acad Sci U S A 2007 Apr 9;104(16):6740-5. Epub 2007 Apr 9.

Department of Radiation and Cellular Oncology, Center for Molecular Oncology, and Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871856PMC
April 2007

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

Nature 2007 Apr;446(7137):765-70

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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April 2007

Balancing BMP signaling through integrated inputs into the Smad1 linker.

Mol Cell 2007 Feb;25(3):441-54

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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February 2007

Beyond tumorigenesis: cancer stem cells in metastasis.

Cell Res 2007 Jan;17(1):3-14

Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA.

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January 2007

Sorting out breast-cancer gene signatures.

Authors:
Joan Massagué

N Engl J Med 2007 Jan;356(3):294-7

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January 2007

Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.

J Biol Chem 2006 Dec 2;281(52):40412-9. Epub 2006 Nov 2.

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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December 2006

Cancer metastasis: building a framework.

Cell 2006 Nov;127(4):679-95

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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November 2006

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.

Cancer Cell 2006 Sep;10(3):203-14

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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September 2006

Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.

Proc Natl Acad Sci U S A 2006 Aug 1;103(32):11940-5. Epub 2006 Aug 1.

Molecular Vertebrate Embryology Laboratory, The Rockefeller University, New York, NY 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567677PMC
August 2006

Is cancer a disease of self-seeding?

Nat Med 2006 Aug;12(8):875-8

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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August 2006

A FoxO-Smad synexpression group in human keratinocytes.

Proc Natl Acad Sci U S A 2006 Aug 14;103(34):12747-52. Epub 2006 Aug 14.

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, and Bioinformatics Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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August 2006

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

Cell 2006 Jun;125(5):929-41

Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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June 2006

The logic of TGFbeta signaling.

FEBS Lett 2006 May 21;580(12):2811-20. Epub 2006 Apr 21.

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, P.O. Box 116, 1275 York Avenue, New York, NY 10021, USA.

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May 2006

Smad transcription factors.

Genes Dev 2005 Dec;19(23):2783-810

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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December 2005

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.

Cancer Cell 2005 Nov;8(5):369-80

Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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November 2005