Publications by authors named "Joan E Wither"

36Publications

Validity evidence supports the use of automated neuropsychological assessment metrics as a screening tool for cognitive impairment in lupus.

Arthritis Care Res (Hoboken) 2019 Oct 18. Epub 2019 Oct 18.

University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/acr.24096DOI Listing
October 2019

Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis.

Semin Arthritis Rheum 2020 02 28;50(1):84-94. Epub 2019 Jun 28.

Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2019.06.017DOI Listing
February 2020

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins.

J Immunol Methods 2018 06 31;457:33-40. Epub 2018 Mar 31.

Cardiovascular Research Institute, Sandler Asthma Basic Research Center, 555 Mission Bay Blvd S, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, 555 Mission Bay Blvd S, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124898PMC
June 2018

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncomms16021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice.

PLoS One 2017 19;12(6):e0179506. Epub 2017 Jun 19.

Arthritis Centre of Excellence, Division of Genetics and Development, Krembil Research Institute, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179506PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476272PMC
September 2017

Invariant NKT Cell Activation Is Potentiated by Homotypic -Ly108 Interactions.

J Immunol 2017 05 3;198(10):3949-3962. Epub 2017 Apr 3.

Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada;

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http://dx.doi.org/10.4049/jimmunol.1601369DOI Listing
May 2017

Development, Sensibility, and Validity of a Systemic Autoimmune Rheumatic Disease Case Ascertainment Tool.

J Rheumatol 2017 01 1;44(1):18-23. Epub 2016 Nov 1.

From the Toronto Scleroderma Program, Division of Rheumatology, Department of Medicine, Toronto Western and Mount Sinai Hospitals; Division of Genetics and Development, and Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network; Arthritis Centre of Excellence, Division of Rheumatology, Departments of Medicine and Immunology, University Health Network; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.160327DOI Listing
January 2017

Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus.

J Rheumatol 2015 Dec 15;42(12):2318-26. Epub 2015 Nov 15.

From the University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network; Division of Rheumatology, Department of Medicine, and Department of Immunology, University of Toronto; Arthritis Centre of Excellence, Division of Health Care and Outcomes Research, Toronto Western Hospital Research Institute, University Health Network; Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.A.J. Steiman, MD, MSc, FRCP, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, and Division of Rheumatology, Department of Medicine, University of Toronto; D.D. Gladman, MD, FRCP, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, and Division of Rheumatology, Department of Medicine, University of Toronto, and Arthritis Centre of Excellence, Division of Health Care and Outcomes Research, Toronto Western Hospital Research Institute, University Health Network; D. Ibañez, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network; B. Noamani, MSc, Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network; C. Landolt-Marticorena, MD, PhD, FRCP, Division of Rheumatology, Department of Medicine, University of Toronto; M.B. Urowitz, MD, FRCP, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, and Division of Rheumatology, Department of Medicine, University of Toronto, and Arthritis Centre of Excellence, Division of Health Care and Outcomes Research, Toronto Wes

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http://dx.doi.org/10.3899/jrheum.150040DOI Listing
December 2015

Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.

J Immunol 2015 Nov 2;195(10):4623-31. Epub 2015 Oct 2.

Arthritis Centre of Excellence, Toronto Western Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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http://www.jimmunol.org/content/early/2015/10/02/jimmunol.15
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1500552
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http://dx.doi.org/10.4049/jimmunol.1500552DOI Listing
November 2015

Interferon-α induces altered transitional B cell signaling and function in Systemic Lupus Erythematosus.

J Autoimmun 2015 Apr 9;58:100-10. Epub 2015 Feb 9.

Arthritis Centre of Excellence, Toronto Western Hospital Research Institute, University of Toronto Faculty of Medicine, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.01.009DOI Listing
April 2015

Immunoglobulin G subclass analysis in psoriatic arthritis.

J Rheumatol 2014 Dec 15;41(12):2421-4. Epub 2014 Oct 15.

From the Division of Rheumatology, Department of Medicine, University of Toronto Psoriatic Arthritis Program, and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.A. Haddad, MD, Clinical Research Fellow; A. Thavaneswaran, MMath, Biostatistician; F. Abji, MSc; F. Pellett, BSc; V. Chandran, MBBS, MD, DM, PhD, Assistant Professor of Medicine; J.E. Wither, MD, PhD, FRCPC, Professor of Medicine and Immunology; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Department of Medicine, Division of Rheumatology, and Director, University of Toronto Psoriatic Arthritis Program, and Deputy Director, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital.

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http://dx.doi.org/10.3899/jrheum.131477DOI Listing
December 2014

Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity.

Hum Immunol 2014 Aug 28;75(8):873-9. Epub 2014 Jun 28.

Department of Kinesiology and Health Science, York University, Canada.

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http://dx.doi.org/10.1016/j.humimm.2014.06.012DOI Listing
August 2014

T cell and dendritic cell abnormalities synergize to expand pro-inflammatory T cell subsets leading to fatal autoimmunity in B6.NZBc1 lupus-prone mice.

PLoS One 2013 20;8(9):e75166. Epub 2013 Sep 20.

Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada ; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779178PMC
May 2014

Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.

J Immunol 2011 May 4;186(10):5845-53. Epub 2011 Apr 4.

Arthritis Center of Excellence, Toronto Western Research Institute, Toronto, Ontario M5T 2S8, Canada.

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http://dx.doi.org/10.4049/jimmunol.1003426DOI Listing
May 2011

Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice.

Clin Immunol 2011 May 17;139(2):215-27. Epub 2011 Mar 17.

Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.clim.2011.02.005DOI Listing
May 2011

An intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice.

Eur J Immunol 2011 Feb 29;41(2):527-36. Epub 2010 Dec 29.

Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/eji.201040983DOI Listing
February 2011

Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus.

J Rheumatol 2010 Aug 1;37(8):1658-66. Epub 2010 Jun 1.

Arthritis Centre of Excellence and Toronto Western Hospital Research Institute, Divisions of Genetics and Development and Population Health, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.091123DOI Listing
August 2010

Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint.

J Rheumatol 2010 Mar 28;37(3):496-502. Epub 2010 Jan 28.

Arthritis Centre of Excellence and Toronto Western Hospital Research Institute, Division of Genetics and Development, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.090317DOI Listing
March 2010

Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus.

J Immunol 2008 Jan;180(2):1276-84

Arthritis Centre of Excellence, Toronto Western Hospital Research Institute, and Department of Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.180.2.1276DOI Listing
January 2008

Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice.

Eur J Immunol 2007 Sep;37(9):2645-56

Department of Immunology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/eji.200737334DOI Listing
September 2007

Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice.

J Immunol 2005 Dec;175(12):8154-64

Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.175.12.8154DOI Listing
December 2005

Molecular basis of antigen recognition by insulin specific T cell receptor.

Immunol Lett 2004 Feb;91(2-3):133-9

Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278-0022, Japan.

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http://dx.doi.org/10.1016/j.imlet.2003.11.001DOI Listing
February 2004

Autoreactive B cells in lupus-prone New Zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo.

J Immunol 2004 Feb;172(3):1553-60

Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.172.3.1553DOI Listing
February 2004