Publications by authors named "Joachim P Steinbach"

100Publications

Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma.

Neuropathol Appl Neurobiol 2020 Oct 20. Epub 2020 Oct 20.

Neurological Institute (Edinger Institute), University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.

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http://dx.doi.org/10.1111/nan.12669DOI Listing
October 2020

ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma.

Int J Radiat Oncol Biol Phys 2020 Nov 30;108(4):987-995. Epub 2020 Jun 30.

Dr Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany; Interdisciplinary Division of Neuro-Oncology, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.021DOI Listing
November 2020

AMPK activation protects astrocytes from hypoxia‑induced cell death.

Int J Mol Med 2020 May 5;45(5):1385-1396. Epub 2020 Mar 5.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, D-60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3892/ijmm.2020.4528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138264PMC
May 2020

Serine-dependent redox homeostasis regulates glioblastoma cell survival.

Br J Cancer 2020 Apr 17;122(9):1391-1398. Epub 2020 Mar 17.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/s41416-020-0794-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188854PMC
April 2020

Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis.

J Clin Med 2019 Dec 16;8(12). Epub 2019 Dec 16.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/jcm8122222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947510PMC
December 2019

Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation.

J Neurooncol 2020 Jan 11;146(1):63-69. Epub 2019 Nov 11.

Department of Neurology, Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s11060-019-03335-4DOI Listing
January 2020

Adrenal Insufficiency in Patients with Corticosteroid-Refractory Cerebral Radiation Necrosis Treated with Bevacizumab.

J Clin Med 2019 Oct 3;8(10). Epub 2019 Oct 3.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/jcm8101608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832264PMC
October 2019

F-FET PET Imaging in Differentiating Glioma Progression from Treatment-Related Changes: A Single-Center Experience.

J Nucl Med 2020 04 13;61(4):505-511. Epub 2019 Sep 13.

Institute of Neuroscience and Medicine (INM-3 and INM-4), Research Center Juelich, Juelich, Germany.

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http://dx.doi.org/10.2967/jnumed.119.234757DOI Listing
April 2020

Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment.

Int J Mol Sci 2019 Sep 10;20(18). Epub 2019 Sep 10.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/ijms20184474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770420PMC
September 2019

EGFR and mTOR as therapeutic targets in glioblastoma.

Oncotarget 2019 Jul 30;10(46):4721-4723. Epub 2019 Jul 30.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; University Cancer Center Frankfurt, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium, Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany; Frankfurt Cancer Institute, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.18632/oncotarget.27094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677661PMC
July 2019

Loss of cell-matrix contact increases hypoxia-inducible factor-dependent transcriptional activity in glioma cells.

Biochem Biophys Res Commun 2019 07 23;515(1):77-84. Epub 2019 May 23.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany; University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.115DOI Listing
July 2019

Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide.

Int J Mol Sci 2019 Mar 1;20(5). Epub 2019 Mar 1.

Dr. Senckenberg Institute of Neurooncology and University Cancer Center (UCT), University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/ijms20051061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429390PMC
March 2019

The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma.

Br J Cancer 2019 03 12;120(5):481-487. Epub 2019 Feb 12.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

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http://www.nature.com/articles/s41416-018-0368-3
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http://dx.doi.org/10.1038/s41416-018-0368-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461855PMC
March 2019

Contrast enhancing spots as a new pattern of late onset pseudoprogression in glioma patients.

J Neurooncol 2019 Mar 2;142(1):161-169. Epub 2019 Jan 2.

Departement of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s11060-018-03076-wDOI Listing
March 2019

Fitting algorithms and baseline correction influence the results of non-invasive in vivo quantitation of 2-hydroxyglutarate with H-MRS.

NMR Biomed 2019 01 20;32(1):e4027. Epub 2018 Nov 20.

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Institute of Neuroradiology, Frankfurt, Germany.

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http://dx.doi.org/10.1002/nbm.4027DOI Listing
January 2019

Rescue of 2-Deoxyglucose Side Effects by Ketogenic Diet.

Int J Mol Sci 2018 Aug 20;19(8). Epub 2018 Aug 20.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://www.mdpi.com/1422-0067/19/8/2462
Publisher Site
http://dx.doi.org/10.3390/ijms19082462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121440PMC
August 2018

Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation.

Int J Mol Sci 2018 Jul 25;19(8). Epub 2018 Jul 25.

Dr. Senckenberg Institute of Neurooncology and University Cancer Center (UCT), University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/ijms19082168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121283PMC
July 2018

Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems.

Int J Mol Sci 2018 May 17;19(5). Epub 2018 May 17.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/ijms19051504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983704PMC
May 2018

Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma.

J Neurochem 2018 02 8;144(4):421-430. Epub 2018 Jan 8.

Dr Senckenberg Institute of Neurooncology, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1111/jnc.14264DOI Listing
February 2018

Bevacizumab for Patients with Recurrent Multifocal Glioblastomas.

Int J Mol Sci 2017 Nov 20;18(11). Epub 2017 Nov 20.

Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.3390/ijms18112469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713435PMC
November 2017

ASA404, a vascular disrupting agent, as an experimental treatment approach for brain tumors.

Oncol Lett 2017 Nov 28;14(5):5443-5451. Epub 2017 Aug 28.

Institute of Neurology (Edinger-Institute), Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.3892/ol.2017.6832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652230PMC
November 2017

Personalized translational epilepsy research - Novel approaches and future perspectives: Part I: Clinical and network analysis approaches.

Epilepsy Behav 2017 11 13;76:13-18. Epub 2017 Sep 13.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1).

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http://dx.doi.org/10.1016/j.yebeh.2017.06.041DOI Listing
November 2017

Personalized translational epilepsy research - Novel approaches and future perspectives: Part II: Experimental and translational approaches.

Epilepsy Behav 2017 11 14;76:7-12. Epub 2017 Sep 14.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1). Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2017.06.040DOI Listing
November 2017

Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine.

Oncol Lett 2017 Jul 25;14(1):1141-1146. Epub 2017 May 25.

University Hospital and University Cancer Center, German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.3892/ol.2017.6251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494648PMC
July 2017

Bevacizumab for Patients with Recurrent Gliomas Presenting with a Gliomatosis Cerebri Growth Pattern.

Int J Mol Sci 2017 Mar 29;18(4). Epub 2017 Mar 29.

Dr. Senckenberg Institute of Neurooncology, Goethe University, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.3390/ijms18040726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412312PMC
March 2017

Intracellular pH measured by P-MR-spectroscopy might predict site of progression in recurrent glioblastoma under antiangiogenic therapy.

J Magn Reson Imaging 2017 10 6;46(4):1200-1208. Epub 2017 Feb 6.

Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/jmri.25619DOI Listing
October 2017

Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study.

PLoS One 2016 29;11(12):e0168113. Epub 2016 Dec 29.

Dr. Senckenberg Institute of Neurooncology, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168113PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198997PMC
July 2017

FOXO3a orchestrates glioma cell responses to starvation conditions and promotes hypoxia-induced cell death.

Int J Oncol 2016 Dec 4;49(6):2399-2410. Epub 2016 Nov 4.

Dr. Senckenberg Institute of Neurooncology, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.3892/ijo.2016.3760DOI Listing
December 2016

Brain invasion in otherwise benign meningiomas does not predict tumor recurrence.

Acta Neuropathol 2016 09 27;132(3):479-81. Epub 2016 Jul 27.

Edinger Institute, Institute of Neurology, Goethe University Frankfurt, 60528, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s00401-016-1598-1DOI Listing
September 2016

To diet or not to diet - that is still the question.

Neuro Oncol 2016 08;18(8):1035-6

Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt, Germany (J.R., J.P.S.); Department of Neurology & Stroke, Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany (J.R.).

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http://dx.doi.org/10.1093/neuonc/now131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933492PMC
August 2016

Prognostic factors in recurrent glioblastoma patients treated with bevacizumab.

J Neurooncol 2016 08 18;129(1):93-100. Epub 2016 May 18.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Schleusenweg 2-16, 60528, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s11060-016-2144-7DOI Listing
August 2016

Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival.

Oncoimmunology 2016 Apr 21;5(4):e1119354. Epub 2015 Dec 21.

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany; German Cancer Consortium (DKTK) partner site Frankfurt/Mainz, Germany.

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http://dx.doi.org/10.1080/2162402X.2015.1119354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839317PMC
April 2016

Activation of AMP-activated kinase modulates sensitivity of glioma cells against epidermal growth factor receptor inhibition.

Int J Oncol 2016 Jul 25;49(1):173-80. Epub 2016 Apr 25.

Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, D-60528 Frankfurt, Germany.

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http://dx.doi.org/10.3892/ijo.2016.3498DOI Listing
July 2016

Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial.

J Clin Oncol 2016 05 14;34(14):1611-9. Epub 2016 Mar 14.

Ulrich Herrlinger, Niklas Schäfer, Frederic Mack, Moritz Stuplich, Sied Kebir, Torsten Pietsch, and Martin Glas, University of Bonn, Bonn; Joachim P. Steinbach and Michael W. Ronellenfitsch, University of Frankfurt, Frankfurt; Astrid Weyerbrock and Horst Urbach, University of Freiburg, Freiburg; Peter Hau and Martin Uhl, University Hospital Regensburg, Regensburg; Roland Goldbrunner and Stefan Grau, University of Cologne, Cologne; Franziska Friedrich and Rolf-Dieter Kortmann, University of Leipzig, Leipzig; Veit Rohde, University of Goettingen, Goettingen; Florian Ringel, Klinikum rechts der Isar Technical University of Munich; Oliver Schnell and Claus Belka, Ludwig Maximillian University of Munich, Munich; Uwe Schlegel, Ruhr-Universität Bochum, Bochum; Michael Sabel and Jaroslaw Maciaczyk, University of Düsseldorf, Düsseldorf; Mathias Hänel, Klinikum Chemnitz, Chemnitz; Dietmar Krex, University of Dresden, Dresden; Peter Vajkoczy, Charité, Humboldt University of Berlin, Berlin; Rüdiger Gerlach, Helios Klinikum Erfurt, Erfurt; Maximilian Mehdorn, University of Kiel, Kiel; Jochen Tüttenberg, Klinikum Idar-Oberstein, Idar-Oberstein; Regine Mayer-Steinacker, University of Ulm, Ulm; Rainer Fietkau, University of Erlangen, Erlangen; Stefanie Brehmer, University of Mannheim, Mannheim; Ralf Kohnen and Elmar Dunkl, RPS Research Germany, Nürnberg; Barbara Leutgeb and Martin Proescholdt, Roche Pharma AG, Grenzach-Wyhlen; and Walter Stummer, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1200/JCO.2015.63.4691DOI Listing
May 2016

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma.

Neuro Oncol 2016 08 21;18(8):1146-56. Epub 2016 Feb 21.

Medical Oncology Department, Bellaria-Maggiore Hospitals, Azienda USL - IRCCS Institute of Neurological Sciences, Bologna, Italy (A.A.B.); Hôpital Avicenne, Paris 13 University, Bobigny, France (A.F.C.); University of California San Diego Health System, La Jolla, California (S.K.); Hospital Universitario 12 de Octubre, Madrid, Spain (J.M.S.-S.); Department of Oncology, Royal North Shore Hospital, St Leonards, Australia (H.R.W.); CHU Hôspital De La Timone, Rue Saint Pierre, France (O.C.); Austin Hospital, Heidelberg, Australia (L.C.); Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Frankfurt, Germany (J.P.S.); Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany (D.C.); Antwerp University Hospital, Edegem, Belgium (P.S.); Medical Oncology, Vall d'Hebron University Hospital and Universitat Autònoma de Barcelona, Barcelona, Spain (J.R.); Eli Lilly and Company, Erl Wood, England (A.C., C.S., I.G., C.M.); Eli Lilly and Company, Indianapolis, Indiana (S.C.G., D.D., M.M.L.); Neurology Clinic, University of Heidelberg, Heidelberg, Germany (W.W.).

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http://dx.doi.org/10.1093/neuonc/now009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933481PMC
August 2016

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma.

J Natl Cancer Inst 2016 May 6;108(5). Epub 2015 Dec 6.

Affiliations of authors:Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main , Germany (CZ, SG, KS, WSW); German Cancer Consortium (DKTK), partner site Frankfurt/Mainz , Germany (CZ, MCB, JPS, WSW); German Cancer Research Center (DKFZ), Heidelberg , Germany (CZ, MCB); Institute for Neurooncology (MCB, JPS), Edinger Institute (LJ, PZ, PNH, MM), Department of Neurology (PZ), and Institute of Neuroradiology (EH), Goethe University, Frankfurt am Main , Germany ; Institute for Transfusion Medicine, German Red Cross Blood Donation Service North-East and Medical Faculty Carl Gustav Carus, TU Dresden , Dresden , Germany (TT).

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http://dx.doi.org/10.1093/jnci/djv375DOI Listing
May 2016

Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas.

Neuro Oncol 2016 Feb 30;18(2):173-83. Epub 2015 Nov 30.

Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany (P.B., A.-E.B., M.D., P.Z., K.H., L.M., K.H.P., P.N.H., M.Mi.); Department of Neurosurgery, Goethe University, Frankfurt, Germany (K.F., V.S.); Dr. Senckenberg Institute of Neurooncology, University of Frankfurt am Main, Frankfurt am Main, Germany (K.F., O.B., J.P.S.); Department of Neuroradiology, University of Frankfurt am Main, Frankfurt am Main, Germany (E.H.); Department of Neurosurgery, University Hospital, Freiburg, Germany (M.Ma.); Cancer Consortium (DKTK), Heidelberg, Germany (O.B., J.P.S., K.H.P, P.N.H., M.Mi.); German Cancer Research Center (DKFZ), Heidelberg, Germany (O.B., J.P.S., K.H.P., P.N.H., M.Mi.); Department of Pathology, University of Heidelberg, Heidelberg, Germany (B.G.).

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http://dx.doi.org/10.1093/neuonc/nov288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724185PMC
February 2016

Comprehensive diagnostics in a case of hereditary diffuse leukodystrophy with spheroids.

BMC Neurol 2015 Jul 4;15:103. Epub 2015 Jul 4.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Schleusenweg 2-16, 60528, Frankfurt, Germany.

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http://dx.doi.org/10.1186/s12883-015-0368-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491230PMC
July 2015

Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors.

PLoS One 2015 19;10(5):e0127123. Epub 2015 May 19.

German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Senckenberg Institute of Neurooncology, University of Frankfurt am Main, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127123PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437987PMC
April 2016

Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics.

Neuro Oncol 2014 Nov 25;16(11):1469-77. Epub 2014 Aug 25.

Neurological Institute (Edinger Institute), Goethe University, Frankfurt am Main, Germany (P.B., T.S., L.J., A.K.B., Mi.M.); Institute of Medical Virology, Goethe University, Frankfurt am Main, Germany (Ma.M., F.R., H.F.R., A.B., R.A., J.C.); German Cancer Consortium, Heidelberg, Germany (J.P.S., Mi.M.); German Cancer Research Center, Heidelberg, Germany (J.P.S., Mi.M.); Department of Neurosurgery, Goethe University, Frankfurt am Main, Germany (K.F., V.S.); Senckenberg Institute of Neurooncology, University of Frankfurt am Main, Germany (K.F., J.P.S.).

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http://dx.doi.org/10.1093/neuonc/nou167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201076PMC
November 2014

Sustained focal antitumor activity of bevacizumab in recurrent glioblastoma.

Neurology 2014 Jul 13;83(3):227-34. Epub 2014 Jun 13.

From the Dr. Senckenberg Institute of Neurooncology (O.B., M.W.R., J.R., J.P.S.), Institute of Neurology (Edinger-Institute) (P.N.H., M.M.), Department of Neurosurgery (L.M.W.), and Institute of Neuroradiology (S.-J.Y., E.H.), University Hospital Frankfurt, Goethe University, Frankfurt; and German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) (O.B., P.N.H., L.M.W., S.-J.Y., M.M., M.W.R., J.R., J.P.S., E.H.), Heidelberg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000000594DOI Listing
July 2014

Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies.

Stereotact Funct Neurosurg 2014 24;92(3):129-39. Epub 2014 Apr 24.

Department of Neurosurgery, Goethe University Frankfurt, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1159/000360582DOI Listing
February 2015

ERGO: a pilot study of ketogenic diet in recurrent glioblastoma.

Int J Oncol 2014 Jun 11;44(6):1843-52. Epub 2014 Apr 11.

Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, D-60528 Frankfurt, Germany.

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http://dx.doi.org/10.3892/ijo.2014.2382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063533PMC
June 2014

Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases.

PLoS One 2014 19;9(3):e92311. Epub 2014 Mar 19.

Edinger Institute, Institute of Neurology, University of Frankfurt am Main, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092311PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960244PMC
November 2014

Prophylactic use of pegfilgrastim in patients treated with a nitrosourea and teniposide for recurrent glioma.

Pharmacotherapy 2014 Jun 11;34(6):633-42. Epub 2014 Mar 11.

Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt, Germany.

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http://doi.wiley.com/10.1002/phar.1409
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http://dx.doi.org/10.1002/phar.1409DOI Listing
June 2014

Quantitative T2 mapping of recurrent glioblastoma under bevacizumab improves monitoring for non-enhancing tumor progression and predicts overall survival.

Neuro Oncol 2013 Oct 7;15(10):1395-404. Epub 2013 Aug 7.

Corresponding Author: Elke Hattingen, MD, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.

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http://dx.doi.org/10.1093/neuonc/not105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779046PMC
October 2013

Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation.

Neuro Oncol 2013 Oct 1;15(10):1405-12. Epub 2013 Aug 1.

Corresponding Author: Wolfgang Wick, MD, Department of Neurooncology, National Center for Tumor Diseases and Neurology Clinic, University Clinic Heidelberg and German Cancer Research Centre, Im Neuenheimer Feld 400, 69120-Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779043PMC
October 2013

Biology of brain metastases and novel targeted therapies: time to translate the research.

Biochim Biophys Acta 2013 Jan 7;1835(1):61-75. Epub 2012 Nov 7.

Department of Radiation Therapy and Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.bbcan.2012.10.005DOI Listing
January 2013

Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis.

J Biol Chem 2012 Sep 10;287(40):33436-46. Epub 2012 Aug 10.

Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460445PMC
September 2012

Radiochemotherapy with temozolomide for patients with glioblastoma. Prognostic factors and long-term outcome of unselected patients from a single institution.

Strahlenther Onkol 2011 Nov 28;187(11):722-8. Epub 2011 Oct 28.

Department of Radiotherapy and Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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November 2011

Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial.

Acta Neurochir (Wien) 2012 Feb 10;154(2):229-35; discussion 235. Epub 2011 Sep 10.

Dr. Senckenberg Institute of Neurooncology, Johann Wolfgang Goethe University Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, Germany.

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February 2012

Bevacizumab-induced tumor calcifications as a surrogate marker of outcome in patients with glioblastoma.

Neuro Oncol 2011 Sep 31;13(9):1020-9. Epub 2011 Jul 31.

Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1093/neuonc/nor099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158018PMC
September 2011

NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri.

Ann Neurol 2011 Sep 27;70(3):445-53. Epub 2011 Jun 27.

Division of Clinical Neuro-oncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany.

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September 2011

Nervous system tumors associated with familial tumor syndromes.

Curr Opin Neurol 2010 Dec;23(6):583-91

International Agency for Research on Cancer (IARC), Lyon, France.

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December 2010

Do brain tumours allow valid conclusions on the localisation of human brain functions?--Objections.

Cortex 2011 Sep 9;47(8):1004-6. Epub 2010 Sep 9.

Center of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany.

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September 2011

Epidermal growth factor receptor and mammalian target of rapamycin as therapeutic targets in malignant glioma: current clinical status and perspectives.

Target Oncol 2010 Sep 19;5(3):183-91. Epub 2010 Sep 19.

Dr. Senckenberg Institute of Neurooncology, Center of Neurology and Neurosurgery, Goethe-University Hospital, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.

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September 2010

Postoperative radiotherapy and concomitant temozolomide for elderly patients with glioblastoma.

Radiother Oncol 2010 Dec 17;97(3):382-6. Epub 2010 Sep 17.

Department of Radiotherapy and OncologyJohann Wolfgang Goethe University, Frankfurt/Main, Germany.

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December 2010

The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.

Mol Cancer Res 2010 Jul 29;8(7):1002-16. Epub 2010 Jun 29.

Experimental Neurosurgery, Goethe-University Hospital, Frankfurt, Germany.

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July 2010

Very late relapses in glioblastoma long-term survivors.

J Neurol 2009 Oct 12;256(10):1756-8. Epub 2009 May 12.

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October 2009