Publications by authors named "Jirina Bartkova"

61Publications

DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.

Mol Oncol 2016 06 3;10(6):879-94. Epub 2016 Mar 3.

Danish Cancer Society Research Center, Copenhagen, Denmark; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; Laboratory of Genome Integrity, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic. Electronic address:

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June 2016

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

J Cell Biol 2016 Feb 25;212(3):281-8. Epub 2016 Jan 25.

Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic Department of Medical Biochemistry and Biophysics, Science For Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institute, 17121 Solna, Sweden

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February 2016

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress.

Mol Oncol 2015 Mar 15;9(3):601-16. Epub 2014 Nov 15.

Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark; Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, CZ-142 20 Prague, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, CZ-775 15 Olomouc, Czech Republic. Electronic address:

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March 2015

Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment.

Mol Oncol 2014 Dec 9;8(8):1667-78. Epub 2014 Jul 9.

Danish Cancer Society Research Center, Copenhagen, Denmark; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

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December 2014

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.

Nat Struct Mol Biol 2013 Dec 17;20(12):1425-33. Epub 2013 Nov 17.

1] Danish Cancer Society Research Center, Copenhagen, Denmark. [2] [3].

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December 2013

Androgen receptor signaling fuels DNA repair and radioresistance in prostate cancer.

Cancer Discov 2013 Nov;3(11):1222-4

1Danish Cancer Society Research Center, Copenhagen, Denmark; and 2Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

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November 2013

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth.

J Exp Med 2012 Mar 5;209(3):507-20. Epub 2012 Mar 5.

Danish Cancer Society Research Center and Centre for Genotoxic Stress Research, DK-2100 Copenhagen, Denmark.

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March 2012

NQO1 expression correlates inversely with NFκB activation in human breast cancer.

Breast Cancer Res Treat 2012 Apr 25;132(3):955-68. Epub 2011 Jun 25.

Department of Obstetrics and Gynecology, Biomedicum Helsinki, Helsinki University Central Hospital, PO Box 700, 00029 Helsinki, Finland.

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April 2012

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

Cell Cycle 2011 Feb 1;10(3):457-68. Epub 2011 Feb 1.

Department of Genome Integrity, Institute of Molecular Genetics v.v.i, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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February 2011

Long-distance inflammatory and genotoxic impact of cancer in vivo.

Proc Natl Acad Sci U S A 2010 Oct 6;107(42):17861-2. Epub 2010 Oct 6.

Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

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October 2010

The combined status of ATM and p53 link tumor development with therapeutic response.

Genes Dev 2009 Aug 16;23(16):1895-909. Epub 2009 Jul 16.

The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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August 2009

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

Cell Cycle 2007 Oct 18;6(19):2344-7. Epub 2007 Jul 18.

Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark.

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October 2007

Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis.

Cancer Res 2006 Nov;66(21):10258-63

Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark.

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November 2006

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

Aging Cell 2006 Oct 15;5(5):379-89. Epub 2006 Aug 15.

Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, Austria.

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October 2006

ATM activation in normal human tissues and testicular cancer.

Cell Cycle 2005 Jun 13;4(6):838-45. Epub 2005 Jun 13.

Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark.

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June 2005

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.

Nature 2005 Apr;434(7035):864-70

Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

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April 2005

Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy.

Exp Cell Res 2005 Mar 10;304(1):149-61. Epub 2004 Dec 10.

Laboratory for Molecular Cardiology and The Heart Centre H:S, Rigshospitalet. 20, Juliane Mariesvej, DK-2100 Copenhagen Ø, Denmark.

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March 2005

Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer.

Oncogene 2004 Nov;23(52):8545-51

Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK-2100, Denmark.

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November 2004

Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines.

Oncogene 2003 Nov;22(50):8063-71

Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

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November 2003

Deregulation of the G1/S-phase control in human testicular germ cell tumours.

APMIS 2003 Jan;111(1):252-65; discussion 265-6

Department of Cell Cycle and Cancer, institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

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January 2003

Deregulation of the RB pathway in human testicular germ cell tumours.

J Pathol 2003 Jun;200(2):149-56

Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark.

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June 2003

The emerging phenotype of the testicular carcinoma in situ germ cell.

APMIS 2003 Jan;111(1):267-78; discussion 278-9

University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.

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January 2003

Cell-cycle regulatory proteins in human wound healing.

Arch Oral Biol 2003 Feb;48(2):125-32

Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

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February 2003

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.

Nat Cell Biol 2003 Mar;5(3):255-60

Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

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March 2003

Involvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro.

Cardiovasc Res 2002 Oct;56(1):64-75

Laboratoriet for Molekylaer Kardiologi and Hjertecenteret H:S, Rigshospitalet. 20, Juliane Mariesvej., Copenhagen Ø, Denmark.

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October 2002