Jiri Aubrecht

Jiri Aubrecht

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Jiri Aubrecht

Jiri Aubrecht

Publications by authors named "Jiri Aubrecht"

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Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.

Clin Transl Sci 2019 Jul 15. Epub 2019 Jul 15.

Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/cts.12663DOI Listing
July 2019

Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells.

Mutat Res 2017 Dec 13;806:51-62. Epub 2017 Sep 13.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, K1A 0K9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2017.09.002DOI Listing
December 2017

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs.

Proc Natl Acad Sci U S A 2017 12 4;114(51):E10881-E10889. Epub 2017 Dec 4.

Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057;

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http://dx.doi.org/10.1073/pnas.1714109114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754797PMC
December 2017

Validation of Transcriptomics-Based In Vitro Methods.

Adv Exp Med Biol 2016;856:243-257

Center for Health Protection, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands.

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http://link.springer.com/10.1007/978-3-319-33826-2_10
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http://dx.doi.org/10.1007/978-3-319-33826-2_10DOI Listing
June 2017

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells.

Environ Mol Mutagen 2015 Jul 2;56(6):505-19. Epub 2015 Mar 2.

Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC.

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http://dx.doi.org/10.1002/em.21941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506269PMC
July 2015

Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.

Toxicol Sci 2015 Feb 29;143(2):268-76. Epub 2014 Oct 29.

*Department of Toxicogenomics, Maastricht University, Maastricht 6200 MD, The Netherlands, Pathology Department, University of Michigan, Ann Arbor, Michigan 48109 and Drug Safety Research and Development, Pfizer, Inc., Groton, Connecticut 06340.

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http://dx.doi.org/10.1093/toxsci/kfu232DOI Listing
February 2015

Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics.

Drug Chem Toxicol 2014 Apr 16;37(2):204-12. Epub 2013 Oct 16.

Drug Safety Research and Development and.

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http://dx.doi.org/10.3109/01480545.2013.834360DOI Listing
April 2014

Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.

Toxicol Sci 2014 Jan 1;137(1):12-25. Epub 2013 Oct 1.

* Biomarkers of Drug Safety Research and Development and.

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http://dx.doi.org/10.1093/toxsci/kft221DOI Listing
January 2014

Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics.

Mol Diagn Ther 2013 Dec;17(6):343-54

Toxadvisor Toxicology Consulting, Hadlyme, CT, USA.

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http://dx.doi.org/10.1007/s40291-013-0049-0DOI Listing
December 2013

The current status of biomarkers for predicting toxicity.

Expert Opin Drug Metab Toxicol 2013 Nov 21;9(11):1391-408. Epub 2013 Aug 21.

Drug Safety Research and Development, Pfizer, Inc. , Eastern Point Road, MS 8274 1260, Groton, CT 06340 , USA.

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http://dx.doi.org/10.1517/17425255.2013.827170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870154PMC
November 2013

Serum glutamate dehydrogenase as a potential biomarker of mitochondrial dysfunction.

Toxicol Sci 2013 Jul 5;134(1):223. Epub 2013 Apr 5.

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http://dx.doi.org/10.1093/toxsci/kft088DOI Listing
July 2013

Assessment of emerging biomarkers of liver injury in human subjects.

Toxicol Sci 2013 Apr 20;132(2):276-83. Epub 2013 Jan 20.

Drug Safety R&D, Pfizer Inc., Groton, Connecticut 06340, USA.

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http://dx.doi.org/10.1093/toxsci/kft009DOI Listing
April 2013

Genomic approaches for investigating mechanisms of genotoxicity.

Toxicol Mech Methods 2006 ;16(2-3):69-77

Pfizer Global Research and Development, Groton, Connecticut, USA.

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http://www.tandfonline.com/doi/full/10.1080/1537652060055829
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http://dx.doi.org/10.1080/15376520600558291DOI Listing
October 2012

Moving forward in human cancer risk assessment.

Environ Health Perspect 2011 Jun 13;119(6):739-43. Epub 2010 Dec 13.

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1002735
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http://dx.doi.org/10.1289/ehp.1002735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114805PMC
June 2011

Predicting safety toleration of pharmaceutical chemical leads: cytotoxicity correlations to exploratory toxicity studies.

Toxicol Lett 2010 Sep 31;197(3):175-82. Epub 2010 May 31.

Discovery Research, CVMED Chemistry, Pfizer Global R&D, Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1016/j.toxlet.2010.05.016DOI Listing
September 2010

Concordance analysis of an in vitro micronucleus screening assay and the regulatory chromosome aberration assay using pharmaceutical drug candidates.

Environ Mol Mutagen 2010 Jan;51(1):39-47

Genetic Toxicology Laboratories, Pfizer Global Research & Development, Groton, Connecticut 06340, USA.

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http://dx.doi.org/10.1002/em.20507DOI Listing
January 2010

Inter-laboratory evaluation of the bioluminescent Salmonella reverse mutation assay using 10 model chemicals.

Mutagenesis 2009 Sep 6;24(5):433-8. Epub 2009 Jul 6.

Pfizer Global Research and Development, Drug Safety Research and Development, Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1093/mutage/gep026DOI Listing
September 2009

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity.

Toxicol Lett 2009 Apr 4;186(1):36-44. Epub 2008 Sep 4.

Bayer HealthCare AG, Special Toxicology, Wuppertal, Germany.

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http://dx.doi.org/10.1016/j.toxlet.2008.08.017DOI Listing
April 2009

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches.

Mutat Res 2009 Mar-Jun;681(2-3):230-40. Epub 2008 Nov 1.

National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 1200 Pennsylvania Avenue, NW Washington, DC 20460, USA.

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http://dx.doi.org/10.1016/j.mrrev.2008.10.001DOI Listing
April 2009

Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes.

Bioorg Med Chem Lett 2009 Apr 28;19(8):2220-3. Epub 2009 Feb 28.

Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, United States.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.099DOI Listing
April 2009

Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.

Bioorg Med Chem Lett 2009 Mar 12;19(6):1559-63. Epub 2009 Feb 12.

Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.032DOI Listing
March 2009

Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals.

Mutat Res 2007 Oct 21;623(1-2):98-108. Epub 2007 Apr 21.

Department of Biochemistry and Molecular & Cellular Biology and the Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.03.013DOI Listing
October 2007

Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment.

Toxicol Sci 2007 Sep 4;99(1):20-5. Epub 2007 Jun 4.

Exploratory Medicinal Sciences, Pfizer Global Research and Development, Groton, CT 06340, USA.

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http://dx.doi.org/10.1093/toxsci/kfm147DOI Listing
September 2007

Bioluminescent Salmonella reverse mutation assay: a screen for detecting mutagenicity with high throughput attributes.

Mutagenesis 2007 Sep 26;22(5):335-42. Epub 2007 Jul 26.

Drug Safety Research and Development, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.

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https://academic.oup.com/mutage/article-lookup/doi/10.1093/m
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http://dx.doi.org/10.1093/mutage/gem022DOI Listing
September 2007

Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae.

Mutat Res 2005 Aug;575(1-2):34-46

Pfizer Global Research and Development, Eastern Point Road, MS 8274-1246, Groton, CT 06340-8014, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070500137
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http://dx.doi.org/10.1016/j.mrfmmm.2005.02.005DOI Listing
August 2005

Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity.

Pharmacogenomics 2005 Jun;6(4):419-28

Pfizer Global Research and Development, Eastern Point Rd, MS 8274-1246 Groton, CT 06340-8014, USA. jiri.aubrecht

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https://www.futuremedicine.com/doi/abs/10.1517/14622416.6.4.
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http://dx.doi.org/10.1517/14622416.6.4.419DOI Listing
June 2005

Yeast DEL assay detects clastogens.

Mutat Res 2005 Apr;582(1-2):116-34

Department of Pathology, Geffen School of Medicine and School of Public Health, UCLA, CA 90095, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138357180500031
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http://dx.doi.org/10.1016/j.mrgentox.2005.01.005DOI Listing
April 2005

In vivo DNA deletion assay to detect environmental and genetic predisposition to cancer.

Methods Mol Biol 2004 ;262:125-39

Department of Pathology, UCLA School of Medicine, Los Angeles, USA.

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http://dx.doi.org/10.1385/1-59259-761-0:125DOI Listing
March 2004

The utility of DNA microarrays for characterizing genotoxicity.

Environ Health Perspect 2004 Mar;112(4):420-2

Division of Toxicology, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.6709
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241894PMC
http://dx.doi.org/10.1289/ehp.6709DOI Listing
March 2004