Publications by authors named "Jinting Liu"

32 Publications

Intranasal oxytocin administration but not peripheral oxytocin regulates behaviors of attachment insecurity: A meta-analysis.

Psychoneuroendocrinology 2021 Jul 24;132:105369. Epub 2021 Jul 24.

College of Life Science, Northwest University, Xi'an 710069, China; Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an 710069, China; College of Medicine, Northwest University, Xi'an 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China. Electronic address:

In light of the roles of oxytocin (OT) in social bonding and interpersonal relationship, studies have examined the roles of OT in human attachment, but by and large previous findings are inconsistent. Here, we conducted - meta-analyses to estimate the associations between peripheral OT level (e.g., blood and salivary OT) and attachment (i.e., attachment dimensions and behaviors of attachment insecurity) and examine the effects of intranasal OT administration on behaviors of attachment insecurity. The analyses indicated that: (1) Peripheral OT level was not significantly associated with attachment dimensions (e.g., attachment anxiety and attachment avoidance) and behaviors of attachment insecurity; (2) intranasal OT administration significantly reduced behaviors of attachment insecurity of neutral contexts, particularly behaviors of attachment avoidance. The findings suggest that intranasal OT administration is an available approach for reducing behaviors of attachment insecurity of interpersonal situations with ambiguous social cues, which implicates suggestions for therapeutic treatments of attachment-related dysfunctions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2021.105369DOI Listing
July 2021

NLRP3-activated bone marrow dendritic cells play antileukemic roles via IL-1β/Th1/IFN-γ in acute myeloid leukemia.

Cancer Lett 2021 Jul 5;520:109-120. Epub 2021 Jul 5.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China. Electronic address:

The bone marrow microenvironment of acute myeloid leukemia (AML) characterized by immunosuppressive features fosters leukemia immune escape. Elucidating the immunosuppressive mechanism and developing effective immunotherapeutic strategies are necessary. Here, we found that the Th1% and IFN-γ level were downregulated in bone marrow of AML and NLRP3-activated BMDCs promoted CD4 T cell differentiation into Th1 cells via IL-1β secretion. However, IFN-γ-producing Th1 cells were not induced by NLRP3-activated BMDCs in the presence of the NLRP3 inflammasome inhibitor MCC950 or anti-IL-1β antibody in vitro unless exogenous IL-1β was replenished. This inhibitory effect on Th1 differentiation was also observed in Nlrp3 mice or anti-IL-1β antibody-treated mice. Notably, elevated Th1 cell levels promoted apoptosis and inhibited proliferation in leukemia cells via IFN-γ secretion in vitro and in vivo. Thus, NLRP3-activated BMDCs promote the proliferation of IFN-γ-producing Th1 cells with antileukemic effects and may provide insight into the basis for leukemia immunotherapy in patients with AML.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2021.06.014DOI Listing
July 2021

OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males.

J Psychiatr Res 2021 08 23;140:221-227. Epub 2021 May 23.

Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy.

Objectives: This study examined the moderation of an oxytocin receptor (OXTR) gene in the link between childhood adversity and depressive symptoms among incarcerated males.

Methods: Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (M = 32.4 years, SD = 9.41, 18-74 years). Moderation analysis was applied to examine the interaction between adverse childhood experiences (including abuse, neglect, and household dysfunction) and the OXTR polymorphisms (rs2254298, rs53576) in predicting depressive symptoms.

Results: Incarcerated males had relatively higher prevalence of childhood adversity (70.2%) and depressive symptoms (49.8%). Higher childhood adversity was associated with increased depressive symptoms, and the effect was more pronounced in the GG homozygotes of OXTR rs2254298 (b = 0.406, p < .001), as compared with the AA/AG carriers (b = 0.236, p < .001). By contrast, the OXTR rs53576 did not interact with childhood adversity in predicting depressive symptoms.

Conclusions: Chinese incarcerated males with the GG genotype of OXTR rs2254298 have higher vulnerability in the effect of childhood adversity on depressive symptoms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2021.05.043DOI Listing
August 2021

Waste activated sludge stimulates in situ microbial reductive dehalogenation of organohalide-contaminated soil.

J Hazard Mater 2021 06 21;411:125189. Epub 2021 Jan 21.

Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-Sen University, Guangzhou 510275, China. Electronic address:

Due to its enriched organic matter, nutrients and growth cofactors, as well as a diverse range of microorganisms, waste activated sludge (WAS) might be an ideal additive to stimulate organohalide respiration for in situ bioremediation of organohalide-contaminated sites. In this study, we investigated the biostimulation and bioaugmentation impacts of WAS-amendment on the performance and microbiome in tetrachloroethene (PCE) and polychlorinated biphenyls (PCBs) dechlorinating microcosms. Results demonstrated that WAS-amendment increased PCE- and PCBs-dechlorination rate as much as 6.06 and 10.67 folds, respectively. The presence of WAS provided a favorable growth niche for organohalide-respiring bacteria (OHRB), including redox mediation and generation of electron donors and carbon sources. Particularly for the PCE dechlorination, indigenous Geobacter and WAS-derived Dehalococcoides were identified to play key roles in PCE-to-dichloroethene (DCE) and DCE-to-ethene dechlorination, respectively. Similar biostimulation and bioaugmentation effects of WAS-amendment were observed on both PCE- and PCBs-dechlorination in three different soils, i.e., laterite, brown loam and paddy soil. Risk assessment suggested low potential ecological risk of WAS amendment in remediation of organohalide-contaminated soil. Overall, this study provided an economic and efficient strategy to stimulate the organohalide respiration-based bioremediation in field applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2021.125189DOI Listing
June 2021

The Difference Spotting Task: A new nonverbal measure of cheating behavior.

Behav Res Methods 2021 Mar 10. Epub 2021 Mar 10.

School of Psychology, Shenzhen University, Shenzhen, 518060, China.

To understand when, how, and why people cheat, the ability to detect cheating in a laboratory setting is crucial. However, commonly used paradigms are confronted with a conflict between allowing participants to believe they can cheat unnoticed and allowing experimenters to detect cheating. This project aimed to develop and establish a new nonverbal task to resolve this conflict. Study 1 and Study 2 developed a new unsolvable paradigm called the Difference Spotting Task. In Study 1, participants were incentivized to indicate whether they found any difference between a pair of pictures without being asked to point the difference(s) out, so they could overreport their performance to earn extra money. Unbeknownst to them, the pairs of pictures from half of the items were identical so that the task could not be solved without cheating. This paradigm allowed experimenters to detect cheating for each unsolvable item. Study 3 examined the validity of the Difference Spotting Task and demonstrated it as a valid tool to assess cheating. The Difference Spotting Task is nonverbal and thus applicable to populations across age, educational level, and culture. In this unsolvable task, participants feel safe in cheating, and experimenters can detect cheating at the item level. The task holds the potential to gain acceptance by many researchers and facilitate the investigation of the underlying processes of cheating behavior.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3758/s13428-020-01526-wDOI Listing
March 2021

Naming is framing: The framing effect of technology name on public attitude toward automated vehicles.

Public Underst Sci 2021 Aug 28;30(6):691-707. Epub 2021 Jan 28.

Lanzhou Jiaotong University, P.R. China.

Vehicles with automated driving systems are called by many names, which are used interchangeably in public discourse, with different and at times misleading meanings. In two studies (total  = 908), we examined the naming effects on people's cognitive (perceived benefit and risk), affective (negative and positive affect), and behavioral responses (behavioral intention) to and trust in these vehicles in the Chinese context. Study 1 considered four names (intelligent, automated, autonomous, and driverless vehicles). Study 2 presented an identical description of vehicles with full automation and considered their five names (fully intelligent, fully automated, fully autonomous, fully driverless, and driverless vehicles). We corroborated the naming effects on affective responses and trust. The framing of "driverless vehicle" was less favorable in Study 1 but more favorable in Study 2. Technology names indirectly influenced behavioral intention through certain cognitive and affective responses. Theoretical and practical implications of our results are discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/0963662520987806DOI Listing
August 2021

N6-methyladenine modification in noncoding RNAs and its function in cancer.

Biomark Res 2020 Nov 10;8(1):61. Epub 2020 Nov 10.

Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. China.

Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RNA modification of mammalian cells, and it involves almost all aspects of RNA metabolism. Recent research revealed tight correlations between m6A modification and ncRNAs and indicated the interaction between m6A and ncRNAs act a pivotal part in the development of cancer. The correlation between m6A modification and ncRNAs provides a new perspective for exploring the potential regulatory mechanism of tumor gene expression, and suggest that m6A modification and ncRNAs may be important prognostic markers and therapeutic targets for multiple cancers. In this review, we summarize the potential regulatory mechanisms between m6A methylation and ncRNAs, highlighting how their relationship affects biological functions in cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40364-020-00244-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653994PMC
November 2020

The OXTR polymorphisms are not associated with attachment dimensions: A three-approach study.

Psychoneuroendocrinology 2020 10 21;120:104780. Epub 2020 Jun 21.

College of Life Science, Northwest University, Xi'an, 710069, China.

Inspired by the roles of oxytocin in social behaviors, scientists have devoted considerable efforts to examine the association between the oxytocin receptor gene (OXTR) and human attachment, a personality of seek and receiving comfort from intimate figures. However, there are still a lot of controversies on the association. To clarify the relationship, this research integrated three studies: (1) A cross-sectional study indicated that the OXTR polymorphisms (i.e., rs53576 and rs2254298) were not significantly associated with attachment dimensions in a college student sample (N = 1193); (2) A three-wave study showed that the polymorphisms were not associated with the individual differences and changes of attachment dimensions in a freshmen sample (N = 657); and (3) Meta-analysis indicated that attachment dimensions were not associated with the polymorphisms of rs53576 (Anxiety: 14 samples, N = 5053; Avoidance: ten samples, N = 4273) and rs2254298 (Anxiety: ten samples, N = 3670; Avoidance: ten samples, N = 3698). Taken together, these findings provide strong evidence that the OXTR polymorphisms are not related to attachment dimensions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2020.104780DOI Listing
October 2020

The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health.

J Affect Disord 2020 07 30;272:277-282. Epub 2020 Apr 30.

College of Life Science, Northwest University, Xi'an 710069, China; College of Medicine, Northwest University, Xi'an 710069, China; Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an 710069, China; Institute of Population and Health, Northwest University, Xi'an 710069, China. Electronic address:

Backgrounds: Alexithymia, difficulties in identifying and describing one's own feelings, is related to substantial clinical practice. Inspired by the links between serotonin functions and affective disorders, this study investigated associations of the serotonin receptor 2A (5-HT2A) gene with alexithymia and mental health.

Methods: We differentiated subjects according to two functional polymorphisms (i.e., rs6311 and rs6313) of 5-HT2A gene and scored alexithymia and mental health of college students with the Toronto Alexithymia Scale (TAS-20) and the Symptom Check List-90 (SCL-90), respectively.

Results: The analyses basing on sample 1 (N = 566) and sample 2 (N = 602) indicated that the G allele of rs6311 was related to higher score on the TAS-20 as compared to the AA genotype. The analysis with 467 individuals from sample 2 indicated that the rs6311 was associated with mental health, and this association was mediated by alexithymia.

Limitations: The potential confounding variables such as depression and anxiety were neglected in the analyses.

Conclusions: These findings demonstrate the contribution of the 5-HT2A to alexithymia, and highlight the link between alexithymia and mental health at genetic level.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2020.03.153DOI Listing
July 2020

Inhibitory effects of metal ions on reductive dechlorination of polychlorinated biphenyls and perchloroethene in distinct organohalide-respiring bacteria.

Environ Int 2020 02 13;135:105373. Epub 2019 Dec 13.

School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China; Environmental Microbiome Research Center, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-Sen University, Guangzhou 510275, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Guangzhou 510275, China. Electronic address:

Bioremediation of sites co-contaminated with organohalides and metal pollutants may have unsatisfactory performance, since metal ions can potentially inhibit organohalide respiration. To understand the detailed impact of metals on organohalide respiration, we tested the effects of four metal ions (i.e., Cu, Cd, Cr and Pb), as well as their mixtures, on reductive dechlorination of perchloroethene (PCE) and polychlorinated biphenyls (PCBs) in three different cultures, including a pure culture of Dehalococcoides mccartyi CG1, a Dehalococcoides-containing microcosm and a Dehalococcoides-Geobacter coculture. Results showed that the inhibitive impact on organohalide respiration depended on both the type and concentration of metal ions. Interestingly, the metal ions might indirectly inhibit organohalide respiration through affecting non-dechlorinating populations in the Dehalococcoides-containing microcosm. Nonetheless, compared to the CG1 pure culture, the Dehalococcoides-containing microcosm had higher tolerance to the individual metal ions. In addition, no synergistic inhibition was observed for reductive dechlorination of PCE and PCBs in cultures amended with metal ion mixtures. These results provide insights into the impact of metal ions on organohalide respiration, which may be helpful for future in situ bioremediation of organohalide-metal co-contaminated sites.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2019.105373DOI Listing
February 2020

Disability and health-related quality of life in Chinese patients with rheumatoid arthritis: A cross-sectional study.

Int J Rheum Dis 2018 Sep;21(9):1709-1715

Department of Rheumatology and Immunology, The People's Hospital of Hebei Province, Shijiazhuang, China.

Aim: The objective of this study was to evaluate the impact of rheumatoid arthritis (RA) on physical function and health-related quality of life (HRQoL) in China.

Method: A cross-section survey was conducted in 21 general hospitals in China. Eight hundred and seven patients were recruited. Data on demographics, clinical data, physical function (Stanford Health Assessment Questionnaire Disability Index, HAQ-DI) and HRQoL (Study Short Form 36 Health Survey, SF-36) were collected on site.

Results: In our cohort, physical function was impaired in 77.6% of patients (HAQ-DI >0). The median (interquartile range, IQR) of HAQ-DI was 0.750 (0.125, 1.500). Rated by HAQ-DI 0-1, >1-2, and >2-3, percentage of patients with mild, moderate and severe disability was 61.0%, 25.4%, and 13.6%, respectively. Older age, long disease duration, presence of extra-articular manifestations, tender joint count (TJC), overall status (assessed by patient Global Visual Analogue Scale [G-VAS] and physician G-VAS) and lacking disease-modifying anti-rheumatic drugs were identified as predictive factors for worse physical function (P < .05). The composite scores of SF-36 in the observed patients were: physical component summary 40.4 (IQR 27.4, 60.3), and mental component summary 49.0 (IQR 33.6, 70.9). Impaired physical health may be predicted by low income, presence of extra-articular manifestations, TJC, patient G-VAS and high HAQ-DI. Predictors for suboptimal mental health were low income, physical labor, married status, increased swollen joint count (SJC), physician G-VAS and high HAQ-DI.

Conclusion: Rheumatoid arthritis has profound effects on physical function and HRQoL in Chinese patients. Patients with identified predictive factors for poor outcome should be closely monitored.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1756-185X.13345DOI Listing
September 2018

A field study of the association between CD38 gene and altruistic behavior: Empathic response as a mediator.

Psychoneuroendocrinology 2017 Nov 12;85:165-171. Epub 2017 Aug 12.

Center for Brain and Cognitive Sciences and School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address:

Inspired by the enhancement effects of oxytocin on empathic responses and altruistic behaviors, we conducted a field study with a real fundraising event and investigated to what extent oxytocin pathway genes (CD38 and OXTR) modulate individual differences in charitable donation. Participants were informed that a teacher in their university was diagnosed with uremia and could not afford the cost of medication. They were given the opportunity to donate any amount of money and report their empathic responses to the misfortune of the teacher. We found a significant association between CD38 rs3796863 and the amount of donation both before and after controlling for gender, age, subjective socioeconomic status, religious belief, and social desirability. Individuals with the genotypes (AA/AC) leading to higher oxytocin levels reported stronger empathic responses and donated more money than individuals with the CC genotype. Moreover, empathic response mediated the gene-altruism association. However, we observed no significant associations between the three polymorphisms of OXTR (rs53576, rs2254298, and rs1042778) and the amount of donation. This study demonstrates the importance of CD38 as a source of individual differences in altruistic behavior and highlights the role of empathic response in bridging the link between the oxytocin pathway gene and altruism.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2017.08.010DOI Listing
November 2017

Melatonin increases reactive aggression in humans.

Psychopharmacology (Berl) 2017 Oct 21;234(19):2971-2978. Epub 2017 Jul 21.

School of Psychological and Cognitive Sciences, Peking University, Beijing, 100871, China.

Objective: Melatonin, a hormone released preferentially by the pineal gland during the night, affects circadian rhythms and aging processes. As animal studies have shown that melatonin increases resident-intruder aggression, this study aimed to investigate the impact of melatonin treatment on human aggression.

Methods: In a double-blind, randomized, placebo-controlled between-participant design, 63 healthy male volunteers completed the Taylor Aggression Paradigm (TAP) after oral administration of melatonin or placebo.

Results: We found that when given the opportunity to administer high or low punishments to an opponent, participants who ingested melatonin selected the high punishment more often than those who ingested placebo. The increased reactive aggression under melatonin administration remained after controlling for inhibitory ability, trait aggression, trait impulsiveness, circadian preference, perceptual sensibility to noise, and changes in subjective sleepiness and emotional states.

Conclusion: This study provides novel and direct evidence for the involvement of melatonin in human social processes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-017-4693-7DOI Listing
October 2017

Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making.

Soc Cogn Affect Neurosci 2017 09;12(9):1534-1544

Center for Brain and Cognitive Sciences.

The framing effect refers the tendency to be risk-averse when options are presented positively but be risk-seeking when the same options are presented negatively during decision-making. This effect has been found to be modulated by the serotonin transporter gene (SLC6A4) and the catechol-o-methyltransferase gene (COMT) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. The current study aimed to identify new genetic variations of genes on dopaminergic and serotonergic pathways that may contribute to individual differences in the susceptibility to framing. Using genome-wide association data and the gene-based principal components regression method, we examined genetic variations of 26 genes on the pathways in 1317 Chinese Han participants. Consistent with previous studies, we found that the genetic variations of the SLC6A4 gene and the COMT gene were associated with the framing effect. More importantly, we demonstrated that the genetic variations of the aromatic-L-amino-acid decarboxylase (DDC) gene, which is involved in the synthesis of both dopamine and serotonin, contributed to individual differences in the susceptibility to framing. Our findings shed light on the understanding of the genetic basis of affective decision-making.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/scan/nsx062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629826PMC
September 2017

Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis.

Psychoneuroendocrinology 2017 Jun 9;80:131-136. Epub 2017 Mar 9.

Center for Brain and Cognitive Sciences and School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address:

Oxytocin in the brain is related to empathy, which refers to the ability to understand and share others' internal states or responses. Previous studies have investigated the impact of OXTR rs53576, the most intensively examined polymorphism in the oxytocin receptor (OXTR) gene, on individual differences in empathy. However, these studies produced inconsistent results. In the current study, we reexamined the association of OXTR rs53576 with empathy in a relatively large population (N=1830) and also evaluated the association by a comprehensive meta-analysis (N=6631, 13 independent samples). The replication study indicated that OXTR rs53576 was indeed associated with individual differences in empathy. Individuals with a greater number of G alleles showed better empathic ability, particularly in fantasizing other's feelings and actions. The meta-analysis not only confirmed this association, but also indicated that the impact of this polymorphism was significant in both Europeans and Asians. These findings provide convincing evidence for the impact of OXTR rs53576 on empathy, highlighting the importance of OXTR gene in individuals' social cognition.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2017.03.005DOI Listing
June 2017

The CAG polymorphism in androgen receptor (AR) gene impacts the moral permissibility of harmful behavior in females.

Psychoneuroendocrinology 2017 Jun 7;80:74-79. Epub 2017 Mar 7.

China Center for Special Economic Zone Research, Shenzhen University, Shenzhen 518060, China; Research Center for Brain Function and Psychological Science, Shenzhen University, Shenzhen 518060, China. Electronic address:

The moral permissibility of harm is strikingly varied among individuals. In light of the connection between testosterone levels and utilitarian moral judgment, this study examined to what extent a CAG polymorphism in the androgen receptor gene, a genetic polymorphism with the ability to regulate testosterone function, contributes to individual differences in moral judgment. Four hundred and thirty-nine Chinese Han participants completed permissibility ratings of harm in moral dilemmas and moral transgression scenarios. Results showed a significant association between the CAG polymorphism and moral permissibility of harm in females. Females with more copies of the S allele, which is associated with higher availability of testosterone, were more likely to judge harmful utilitarian acts and unintentionally harmful acts as permissible, while these effects were absent in males. The findings provide the first evidence for a link between the androgen receptor gene and moral judgment and highlight the role of androgens in moral foundations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2017.03.008DOI Listing
June 2017

The association between well-being and the COMT gene: Dispositional gratitude and forgiveness as mediators.

J Affect Disord 2017 May 7;214:115-121. Epub 2017 Mar 7.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China. Electronic address:

Backround: Previous studies have demonstrated the contributions of genetic variants and positive psychological traits (e.g. gratitude and forgiveness) to well-being. However, little is known about how genes interact with positive traits to affect well-being.

Methods: To investigate to what extent the COMT Val158Met polymorphism modulates well-being and to what extent dispositional gratitude and forgiveness mediate the individual differences in well-being, 445 participants were recruited and required to complete a battery of questionnaires.

Results: We found that individuals with a smaller number of the Met alleles reported greater well-being, less depressive symptoms, and greater tendencies for gratitude and forgiveness. Moreover, dispositional gratitude and forgiveness mediated the genotype effects on well-being and depressive symptoms. These results remained significant after controlling for non-genetic factors (socioeconomic status, religious beliefs, romantic relationship status, parenting style).

Limitation: The sample size limits the generalizability of results.

Conclusion: This study demonstrates the contribution of the COMT Val158Met polymorphism to individual differences in well-being and suggests a potential psychobiological pathway from dopaminergic and noradrenergic systems to happiness.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2017.03.005DOI Listing
May 2017

Investigating the Genetic Basis of Social Conformity: The Role of the Dopamine Receptor 3 (DRD3) Gene.

Neuropsychobiology 2016 27;74(1):32-40. Epub 2016 Oct 27.

Center for Brain and Cognitive Sciences, Peking University, Beijing, China.

Background: People often change their opinions or behavior to match the responses of others, a phenomenon known as social conformity. Conforming behavior varies substantially across individuals. However, little is known about the genetic basis underlying individual differences in social conformity. A recent study demonstrated an association between enhanced dopaminergic function and increased conforming behavior. Given the effect of the dopamine receptor 3 gene (DRD3) Ser9Gly polymorphism (rs6280) on dopamine release in the striatum, this study investigated to what extent this polymorphism affects conforming behavior.

Methods: We categorized Han Chinese individuals according to the polymorphism and tested them with a facial-attractiveness rating task.

Results: We found that individuals with a greater number of the Gly alleles, which are related to an increased dopamine release in the striatum, were more susceptible to social influence and more likely to change their ratings to match those of other people.

Conclusions: This finding demonstrates the importance of DRD3 Ser9Gly as a genetic basis for social conformity and in predicting individual differences in social learning.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000450710DOI Listing
February 2017

Single dose testosterone administration reduces loss chasing in healthy females.

Psychoneuroendocrinology 2016 09 9;71:54-7. Epub 2016 May 9.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, China; Key Laboratory of Machine Perception (Ministry of Education), Peking University, Beijing, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China; IDG/McGovern Institute for Brain Research, Peking University, Beijing, China. Electronic address:

Testosterone has been linked to modulation of impulsivity and risky choice, potentially mediated by changes in reward or punishment sensitivity. This study investigated the effect of testosterone on risk-taking and the adjustment of risk-taking on trials following a gain or a loss. Loss chasing is operationalized herein as the propensity to recover losses by increasing risky choice. Healthy female participants (n=26) received a single-dose of 0.5mg sublingual testosterone in a double-blind, placebo-controlled crossover design. At 240min post-administration, participants performed a gambling task with a high and a low risk option. In the placebo condition, participants were more likely to choose the high risk option following losses compared to wins. This effect was abolished on the testosterone session. Ignoring prior outcomes, no overall changes in risk-taking were observed. Our data indicate that testosterone affects human decision-making via diminishing sensitivity to punishment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2016.05.005DOI Listing
September 2016

COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator.

Hum Brain Mapp 2016 May 25;37(5):1880-92. Epub 2016 Feb 25.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, 100871, China.

Individuals tend to avoid risk in a gain frame, in which options are presented in a positive way, but seek risk in a loss frame, in which the same options are presented negatively. Previous studies suggest that emotional responses play a critical role in this "framing effect." Given that the Met allele of COMT Val158Met polymorphism (rs4680) is associated with the negativity bias during emotional processing, this study investigated whether this polymorphism is associated with individual susceptibility to framing and which brain areas mediate this gene-behavior association. Participants were genotyped, scanned in resting state, and completed a monetary gambling task with options (sure vs risky) presented as potential gains or losses. The Met allele carriers showed a greater framing effect than the Val/Val homozygotes as the former gambled more than the latter in the loss frame. Moreover, the gene-behavior association was mediated by resting-state functional connectivity (RSFC) between orbitofrontal cortex (OFC) and bilateral amygdala. Met allele carriers showed decreased RSFC, thereby demonstrating higher susceptibility to framing than Val allele carriers. These findings demonstrate the involvement of COMT Val158Met polymorphism in the framing effect in decision-making and suggest RSFC between OFC and amygdala as a neural mediator underlying this gene-behavior association. Hum Brain Mapp 37:1880-1892, 2016. © 2016 Wiley Periodicals, Inc.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.23142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867526PMC
May 2016

Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits.

Front Hum Neurosci 2015 23;9:575. Epub 2015 Oct 23.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University Beijing, China ; Key Laboratory of Machine Perception (Ministry of Education), Peking University Beijing, China ; IDG/McGovern Institute for Brain Research, Peking University Beijing, China.

Previous studies have indicated that empathic traits, such as perspective taking, are associated with the levels of serotonin in the brain and with autism spectrum conditions. Inspired by the finding that the serotonin receptor 2A gene (HTR2A) modulates the availability of serotonin, this study investigated to what extent HTR2A modulates individuals' perspective taking ability and autistic-like traits. To examine the associations of the functional HTR2A polymorphism T102C (rs6313) with individuals' perspective taking abilities and autistic-like traits, we differentiated individuals according to this polymorphism and measured empathic and autistic-like traits with Interpersonal Reactivity Index (IRI) and Autism-Spectrum Quotient (AQ) scale in 523 Chinese people. The results indicated that this polymorphism was significantly associated with the scores on Perspective Taking and Personal Distress subscales of IRI, and Communication subscale of AQ. Individuals with a greater number of the C alleles were less likely to spontaneously adopt the point of view of others, more likely to be anxious when observing the pain endured by others, and more likely to have communication problems. Moreover, the genotype effect on communication problems was mediated by individuals' perspective taking ability. These findings provide evidence that the HTR2A T102C polymorphism is a predictor of individual differences in empathic and autistic-like traits and highlight the role of the gene in the connection between perspective taking and autistic-like traits.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnhum.2015.00575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615938PMC
November 2015

The impact of rheumatoid arthritis on work capacity in Chinese patients: a cross-sectional study.

Rheumatology (Oxford) 2015 Aug 22;54(8):1478-87. Epub 2015 Mar 22.

Department of Rheumatology and Immunology, Bethune International Peace Hospital of PLA, Shijiazhuang.

Objective: To evaluate the impact of RA on work capacity and identify factors related to work capacity impairment in patients with RA.

Methods: A cross-sectional multicentre study was performed in 21 tertiary care hospitals across China. A consecutive sample of 846 patients with RA was recruited, of which 589 patients of working age at disease onset constituted the study population. Information on the socio-demographic, clinical, working and financial conditions of the patients was collected. Logistic regression analyses were used to identify factors associated with work capacity impairment.

Results: The rate of work capacity impairment was 48.0% in RA patients with a mean disease duration of 60 months (interquartile range 14-134 months), including 11.7% leaving the labour force early, 33.6% working reduced hours and 2.7% changing job. Multivariable logistic regression analysis showed that reduced working hours was significantly related to current smoking [odds ratio (OR) 2.07 (95% CI 1.08, 3.97)], no insurance [OR 1.94 (95% CI 1.20, 3.12)], in manual labour [OR 2.66 (95% CI 1.68, 4.20)] and higher HAQ score [OR 2.22 (95% CI 1.36, 3.60)]. There was an association of current smoking [OR 3.75 (95% CI 1.54, 9.15)], in manual labour [OR 2.33 (95% CI 1.17, 4.64)], longer disease duration [OR 1.01 (95% CI 1.00, 1.01)] and lower BMI [OR 0.90 (95% CI 0.82, 0.99)] with leaving the labour force early.

Conclusion: There is a substantial impact of RA on the work capacity of patients in China. Social-demographic, disease- and work-related factors are all associated with work capacity impairment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kev014DOI Listing
August 2015

The association between romantic relationship status and 5-HT1A gene in young adults.

Sci Rep 2014 Nov 20;4:7049. Epub 2014 Nov 20.

1] Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing 100871, China [2] Key Laboratory of Machine Perception (Ministry of Education), Peking University, Beijing 100871, China [3] PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.

What factors determine whether or not a young adult will fall in love? Sociological surveys and psychological studies have shown that non-genetic factors, such as socioeconomic status, external appearance, and personality attributes, are crucial components in romantic relationship formation. Here we demonstrate that genetic variants also contribute to romantic relationship formation. As love-related behaviors are associated with serotonin levels in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene is related to relationship status in 579 Chinese Han people. We found that 50.4% of individuals with the CC genotype and 39.0% with CG/GG genotype were in romantic relationship. Logistic regression analysis indicated that the C-1019G polymorphism was significantly associated with the odds of being single both before and after controlling for socioeconomic status, external appearance, religious beliefs, parenting style, and depressive symptoms. These findings provide, for the first time, direct evidence for the genetic contribution to romantic relationship formation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep07049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238299PMC
November 2014

Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation.

Psychoneuroendocrinology 2014 Dec 16;50:274-9. Epub 2014 Sep 16.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing 100871, China; Key Laboratory of Machine Perception (Ministry of Education), Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address:

Previous studies have indicated that alexithymia is associated with the availability of serotonin in the brain and with the insecure attachment orientation. Inspired by the finding that the receptor 5-HT1A modulates the level of serotonin in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene modulates individuals' alexithymic characteristics and attachment orientation in 504 Chinese Han people. Results showed significantly higher total scores on the 20-item Toronto Alexithymia Scale (TAS-20) for individuals carrying the CG/GG genotype than for individuals carrying the CC genotype. Specifically, individuals with the CG/GG genotype reported greater difficulty in identifying own feelings than individuals with the CC genotype. Results also showed that individuals carrying the CG/GG genotype seemed to be less comfortable with having close relationships to others than individuals with the CC genotype. These findings provide the first evidence for the link between 5-HT1A and the development of alexithymic characteristics and attachment orientation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2014.09.001DOI Listing
December 2014

Dopamine beta-hydroxylase gene modulates individuals' empathic ability.

Soc Cogn Affect Neurosci 2014 Sep 29;9(9):1341-5. Epub 2013 Aug 29.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing 100871, Laboratory of Medical Molecular Biology, Henan University of Science and Technology, Luoyang 471003, China, Key Laboratory of Machine Perception (Ministry of Education) and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing 100871, Laboratory of Medical Molecular Biology, Henan University of Science and Technology, Luoyang 471003, China, Key Laboratory of Machine Perception (Ministry of Education) and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing 100871, Laboratory of Medical Molecular Biology, Henan University of Science and Technology, Luoyang 471003, China, Key Laboratory of Machine Perception (Ministry of Education) and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China

Dopamine beta-hydroxylase (DBH), an enzyme that converts dopamine to norepinephrine, has broad influences on social functions. In this study, we examined to what extent two polymorphisms (-1021C/T and a 19 bp insertion/deletion) in DBH gene modulate individuals' empathic perception and response, which were measured, respectively, by reading the mind in the eyes test and the empathic concern subscale of interpersonal reactivity index. Results showed that polymorphism at -1021C/T, but not the 19 bp insertion/deletion, accounts for 2.3% variance of empathic perception and 1.4% variance of empathic response. Individuals with the CC genotype, which is associated with higher DBH activity, manifested greater empathic ability than those with CT/TT genotypes. These findings demonstrate the importance of DBH -1021C/T as a genetic basis of empathy and in predicting individual differences in social and affective processing.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/scan/nst122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158372PMC
September 2014

Gum chewing inhibits the sensory processing and the propagation of stress-related information in a brain network.

PLoS One 2013 3;8(4):e57111. Epub 2013 Apr 3.

Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, China.

Stress is prevalent in human life and threatens both physical and mental health; stress coping is thus of adaptive value for individual's survival and well-being. Although there has been extensive research on how the neural and physiological systems respond to stressful stimulation, relatively little is known about how the brain dynamically copes with stress evoked by this stimulation. Here we investigated how stress is relieved by a popular coping behavior, namely, gum chewing. In an fMRI study, we used loud noise as an acute stressor and asked participants to rate their feeling of stress in gum-chewing and no-chewing conditions. The participants generally felt more stressful when hearing noise, but less so when they were simultaneously chewing gum. The bilateral superior temporal sulcus (STS) and the left anterior insula (AI) were activated by noise, and their activations showed a positive correlation with the self-reported feeling of stress. Critically, gum chewing significantly reduced the noise-induced activation in these areas. Psychophysiological interaction (PPI) analysis showed that the functional connectivity between the left AI and the dorsal anterior cingulate cortex (dACC) was increased by noise to a lesser extent when the participants were chewing gum than when not chewing gum. Dynamic causality modeling (DCM) demonstrated that gum chewing inhibited the connectivity from the STS to the left AI. These findings demonstrate that gum chewing relieves stress by attenuating the sensory processing of external stressor and by inhibiting the propagation of stress-related information in the brain stress network.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057111PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616056PMC
October 2013

Investigation of fragment doses produced by heavy ions in tissue-like material.

Radiat Prot Dosimetry 2012 Jan 28;148(1):126-31. Epub 2011 Feb 28.

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China.

In this paper, the distribution of fragments produced by 55 MeV/n ⁴⁰Ar¹⁷⁺ ions in tissue-equivalent material is reported as a function angles relative to the incident particle direction. The relative fragment doses at different angles and the total dose due to the primary beam have been estimated. The results show that the fragments produced by primary beam were concentrated at very small angles, so the fraction of particle fluence diverging from the primary beam was very small. Even though the diverging fluence is a small fraction of the total, it should still be taken into account because biological systems are very sensitive to low doses of heavy ion irradiation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/rpd/ncr004DOI Listing
January 2012

Preparation of monoclonal antibody for melamine and development of an indirect competitive ELISA for melamine detection in raw milk, milk powder, and animal feeds.

J Agric Food Chem 2010 Jul;58(14):8152-7

The School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, People's Republic of China.

Melamine (MEL) has been involved in several food recalls after the discovery of severe kidney damages in children and pets poisoned by melamine-adulterated food. To detect MEL residue in foods and animal feeds, an indirect competitive ELISA (cELISA) method was developed in this study based on preparation of monoclonal antibodies (MAbs) to MEL. The immunogen was prepared by linking MEL hapten with carrier protein via carbodiimide method. The method is applicable in the range of 5.0-135.0 microg L(-1) MEL in buffer solution, with an IC(50) value of 22.6 +/- 1.9 microg L(-1). The MAbs showed high specificity with low cross-reactivity (< or =1%) toward cyanurate, ammelide, and ammeline. The method was utilized in the detection of MEL in raw milk, milk powder, and animal feeds, with detection limits of 0.1 mg L(-1) for milk, 0.2 mg kg(-1) for milk powder, and 0.5 mg L(-1) for feeds. The recovery ratio was 79-110% for all matrices. The intra-assay and interassay coefficients of variation were <12.0 and <13.0%, respectively. Finally, the application of the cELISA in quantity evaluation of MEL in various feeds from local markets was evaluated and discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf1006209DOI Listing
July 2010

Specificity of face processing without awareness.

Conscious Cogn 2010 Mar 29;19(1):408-12. Epub 2010 Jan 29.

Department of Psychology, Sun-Yat-Sen University, Guangzhou, China.

The recognition memory for inverted faces is especially difficult when compared with that for non-face stimuli. This face inversion effect has often been used as a marker of face-specific holistic processing. However, whether face processing without awareness is still specific remains unknown. The present study addressed this issue by examining the face inversion effect with the technique of binocular rivalry. Results showed that invisible upright faces could break suppression faster than invisible inverted faces. Nevertheless, no difference was found for invisible upright houses and invisible inverted houses. This suggested that face processing without awareness is still specific. Some face-specific information can be processed by high-level brain areas even when that information is invisible.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.concog.2009.12.009DOI Listing
March 2010

One-Pot Green Synthesis and Bioapplication ofl-Arginine-Capped Superparamagnetic Fe3O4 Nanoparticles.

Nanoscale Res Lett 2009 Nov 13;5(2):302-7. Epub 2009 Nov 13.

Key Laboratory for Colloid & Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, 250100, Jinan, People's Republic of China.

Water-solublel-arginine-capped Fe3O4 nanoparticles were synthesized using a one-pot and green method. Nontoxic, renewable and inexpensive reagents including FeCl3,l-arginine, glycerol and water were chosen as raw materials. Fe3O4 nanoparticles show different dispersive states in acidic and alkaline solutions for the two distinct forms of surface bindingl-arginine. Powder X-ray diffraction and X-ray photoelectron spectroscopy were used to identify the structure of Fe3O4 nanocrystals. The products behave like superparamagnetism at room temperature with saturation magnetization of 49.9 emu g-1 and negligible remanence or coercivity. In the presence of 1-ethyl-3-(dimethylaminopropyl) carbodiimide hydrochloride, the anti-chloramphenicol monoclonal antibodies were connected to thel-arginine-capped magnetite nanoparticles. The as-prepared conjugates could be used in immunomagnetic assay.(See supplementary material 1).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11671-009-9480-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894311PMC
November 2009
-->