Publications by authors named "Jintao Xiu"

5 Publications

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Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg/curcumin from injectable self-healing hydrogels.

Theranostics 2021 3;11(12):5911-5925. Epub 2021 Apr 3.

Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Poor healing response after rotator cuff reconstruction is multifactorial, with the inflammatory microenvironment and deficiency of stem cell differentiation factors at the lesion site being most relevant. However, there is a lack of effective tissue engineering strategies that can simultaneously exert anti-inflammatory and pro-differentiation effects to promote rotator cuff healing. In this study, we synthesized and characterized a novel active drug delivery vector that successfully overcame the challenge of simultaneous high-efficiency loading and controlled release of Mg and curcumin. The anti-inflammatory and pro-differentiation effects of the composite hydrogel were evaluated and . Moreover, healing of the rotator cuff tendon-to-bone interface was studied by histology, immunofluorescence, and biomechanical tests. The composite hydrogel exhibited excellent biocompatibility and injectability, good adhesiveness, and rapid self-healing. The released curcumin showed obvious anti-inflammatory and antioxidation effects, which protected stem cells and tendon matrix. Furthermore, released Mg promoted stem cell aggregation and chondrogenesis. Moreover, biomechanical tests and histological results of a rat rotator cuff tear model at 8 weeks after surgery indicated that the composite hydrogel significantly enhanced tendon-to-bone healing. The composite hydrogel mediated sustained release of curcumin and Mg to effectively promote rotator cuff tendon-to-bone healing via anti-inflammatory and pro-differentiation effects. Therefore, this composite hydrogel offers significant promise for rotator cuff repair.
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http://dx.doi.org/10.7150/thno.56266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058719PMC
April 2021

Biomechanical analysis of a novel clavicular hook plate for the treatment of acromioclavicular joint dislocation: A finite element analysis.

Comput Biol Med 2021 Apr 14;133:104379. Epub 2021 Apr 14.

The Second Department of Orthopedics, Xi'an Centeral Hospital, No. 161, West Fifth Road, Xincheng District, Xi'an, 710003, Shaanxi, China. Electronic address:

Background: Clavicular hook plates are frequently used in clinical orthopedics to treat acromioclavicular joint dislocation. However, patients often exhibit acromial osteolysis and peri-implant fracture after hook plate fixation. To solve the above problems, we developed a novel double-hook clavicular plate and used finite element analysis (FEA) to investigate its biomechanical properties.

Methods: A finite element (FE) model was constructed and validated. Then, a double-hook clavicular plate, a single-hook clavicular plate, and an anatomical double-hook clavicular plate was implanted into the acromioclavicular joint and fixed with screws in groups 1, 2 and 3, respectively. Finally, a load was applied, and some indicators were recorded and analyzed.

Results: For both the proximal clavicular rotation angle and the distal clavicular displacement, the range of motion in groups 1 and 3 was more than 90% lower than that in group 2. The maximum von Mises stress of the clavicle in groups 1 and 3 was more than 45% lower than that in group 2. The maximum stress of the acromion in group 2 was significantly higher than that in groups 1 and 3, and that in group 3 was less than that in group 1, for both cortical and cancellous bone.

Conclusions: The double-hook clavicular plate could immediately reconstruct the stability of the acromioclavicular joint, effectively reducing the stress of the bone around the clavicle and screws. Additionally, the double-hook clavicular plate could reduce the peak stress of the acromion and produce a more uniform stress distribution.
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http://dx.doi.org/10.1016/j.compbiomed.2021.104379DOI Listing
April 2021

Biomechanical properties of a novel nonfusion artificial vertebral body for anterior lumbar vertebra resection and internal fixation.

Sci Rep 2021 Jan 29;11(1):2632. Epub 2021 Jan 29.

Department of Spine and Spinal Cord Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou Umiversity, Zhengzhou, 450003, China.

The aim of the study was to evaluate the biomechanical properties of a novel nonfused artificial vertebral body in treating lumbar diseases and to compare with those of the fusion artificial vertebral body. An intact finite element model of the L1-L5 lumbar spine was constructed and validated. Then, the finite element models of the fusion group and nonfusion group were constructed by replacing the L3 vertebral body and adjacent intervertebral discs with prostheses. For all finite element models, an axial preload of 500 N and another 10 N m imposed on the superior surface of L1. The range of motion and stress peaks in the adjacent discs, endplates, and facet joints were compared among the three groups. The ranges of motion of the L1-2 and L4-5 discs in flexion, extension, left lateral bending, right lateral bending, left rotation and right rotation were greater in the fusion group than those in the intact group and nonfusion group. The fusion group induced the greatest stress peaks in the adjacent discs and adjacent facet joints compared to the intact group and nonfusion group. The nonfused artificial vertebral body could better retain mobility of the surgical site after implantation (3.6°-8.7°), avoid increased mobility and stress of the adjacent discs and facet joints.
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http://dx.doi.org/10.1038/s41598-021-82086-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846776PMC
January 2021

Biomechanical study of space frame structure based on bone cement screw.

Exp Ther Med 2020 Jun 9;19(6):3650-3656. Epub 2020 Apr 9.

Department of Orthopaedics, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China.

Stability of space frame structures with bone cement screw reinforcement by biomechanical testing was analyzed. Seven complete human spine specimens with osteoporosis were selected. Three specimens were separated into 18 vertebral bodies. Nine vertebral bodies were randomly selected and bone cement screws were implanted on both sides. Bone cement was used to form a bridge at the front end of the two screws (single vertebral group A). The other nine vertebral bodies were implanted with cement screws on both sides, but the front ends of the two screws were not bridged (single vertebral group B). The remaining spine specimens were used for biomechanical testing of the overall stability of the three-dimensional frame. The four specimens were osteotomized, and then two specimens were randomly selected. Bone cement screws were implanted on both sides of the vertebral body, and a bone cement bridge was formed at the front end of the two screws to establish a three-dimensional frame structure (multi-vertebral group A). The other two spine specimens were implanted with cement screws on both sides of the vertebral body, but the front ends of the two screws were not bridged (multi-vertebral group B). A statistical difference was found between the extractive force of bridged and non-bridged specimens. Group B showed some loosening of screws after the test. The stability of the triangle structure screw, which was formed after the bridge was established at the front end of the single-vertebral bone cement screw, was significantly enhanced. Moreover, the stability was significantly improved after the three-dimensional frame structure was established in the multi-vertebral body group, providing a new method for clinical improvement of the stability and reliability of internal fixation in patients with severe osteoporosis and spinal disease.
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http://dx.doi.org/10.3892/etm.2020.8659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197252PMC
June 2020

Different angiogenic abilities of self-setting calcium phosphate cement scaffolds consisting of different proportions of fibrin glue.

Biomed Res Int 2014 10;2014:785146. Epub 2014 Jun 10.

Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Street, Xi'an 710032, China.

To investigate the different angiogenic abilities of the self-setting calcium phosphate cement (CPC) consisting of different proportions of fibrin glue (FG), the CPC powder and the FG solution were mixed at the powder/liquid (P/L) ratios of 1 : 0.5, 1 : 1, and 1 : 2 (g/mL), respectively, and pure CPC was used as a control. After being implanted into the lumbar dorsal fascia of the rabbit, the angiogenic process was evaluated by histological examination and CD31 immunohistochemistry to detect the new blood vessels. The result of the new blood vessel showed that the P/L ratio of 1 : 1 group indicated the largest quantity of new blood vessel at 4 weeks, 8 weeks, and 12 weeks after implantation, respectively. The histological evaluation also showed the best vascular morphology in the 1 : 1 group at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. Our study indicated that the CPC-FG composite scaffold at the P/L ratio of 1 : 1  (g/mL) stimulated angiopoiesis better than any other P/L ratios and has significant potential as the bioactive material for the treatment of bone defects.
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http://dx.doi.org/10.1155/2014/785146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070487PMC
August 2015