Jinlin Hou

Jinlin Hou

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Jinlin Hou

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Management Algorithm for Interrupting Mother-to-Child Transmission of Hepatitis B Virus.

Clin Gastroenterol Hepatol 2019 Sep 9;17(10):1929-1936.e1. Epub 2018 Oct 9.

School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183109
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http://dx.doi.org/10.1016/j.cgh.2018.10.007DOI Listing
September 2019

Sequential combination therapy with interferon, interleukin-2 and therapeutic vaccine in entecavir-suppressed chronic hepatitis B patients: the Endeavor study.

Hepatol Int 2019 Sep 6;13(5):573-586. Epub 2019 Jun 6.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.

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http://dx.doi.org/10.1007/s12072-019-09956-1DOI Listing
September 2019

Impacts of cigarette smoking on liver fibrosis and its regression under therapy in male patients with chronic hepatitis B.

Liver Int 2019 Aug 15;39(8):1428-1436. Epub 2019 Apr 15.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1111/liv.14108DOI Listing
August 2019

Longitudinal Change of Body Mass Index Is Associated With Alanine Aminotransferase Elevation After Complete Viral Suppression in Chronic Hepatitis B Patients.

J Infect Dis 2019 Aug 2. Epub 2019 Aug 2.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1093/infdis/jiz326DOI Listing
August 2019

Reply.

Clin Gastroenterol Hepatol 2019 Aug 5. Epub 2019 Aug 5.

Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1016/j.cgh.2019.07.049DOI Listing
August 2019

Correction to: Molecular pattern of lncRNAs in hepatocellular carcinoma.

J Exp Clin Cancer Res 2019 Aug 14;38(1):352. Epub 2019 Aug 14.

State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, GuangZhou, 510515, China.

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http://dx.doi.org/10.1186/s13046-019-1339-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693160PMC
August 2019

Therapeutic strategies for hepatitis B virus infection: towards a cure.

Nat Rev Drug Discov 2019 Aug 27. Epub 2019 Aug 27.

Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1038/s41573-019-0037-0DOI Listing
August 2019

ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice.

Gastroenterology 2019 Jul 27. Epub 2019 Jul 27.

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.07.036DOI Listing
July 2019

Association Between Negative Results From Tests for HBV DNA and RNA and Durability of Response After Discontinuation of Nucles(t)ide Analogue Therapy.

Clin Gastroenterol Hepatol 2019 Jul 27. Epub 2019 Jul 27.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.07.046DOI Listing
July 2019

Lower Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir in Patients With Chronic Hepatitis B.

JAMA Oncol 2019 Jun;5(6):915

Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

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http://dx.doi.org/10.1001/jamaoncol.2019.0644DOI Listing
June 2019

Long-term efficacy and safety of tenofovir disoproxil fumarate in Chinese patients with chronic hepatitis B: 5-year results.

Hepatol Int 2019 May 11;13(3):260-269. Epub 2019 Apr 11.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Hepatology Unit and Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

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http://dx.doi.org/10.1007/s12072-019-09943-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529393PMC
May 2019

Molecular pattern of lncRNAs in hepatocellular carcinoma.

J Exp Clin Cancer Res 2019 May 16;38(1):198. Epub 2019 May 16.

State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institute of Liver Diseases Research of Guangdong Province, Guangzhou, China.

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http://dx.doi.org/10.1186/s13046-019-1213-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524221PMC
May 2019

Variants in STAT4 Associated With Cure of Chronic HBV Infection in HBeAg-positive Patients Treated With Pegylated Interferon-alpha.

Clin Gastroenterol Hepatol 2019 Apr 28. Epub 2019 Apr 28.

State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institutes of Liver Diseases Research of Guangdong Province, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, GuangZhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.04.044DOI Listing
April 2019

Interleukin 21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)-Specific CD8+ T Cells in Chronic HBV Infection.

J Infect Dis 2019 Feb;219(5):750-759

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1093/infdis/jiy576DOI Listing
February 2019

Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension.

Radiology 2019 Feb 20;290(2):370-377. Epub 2018 Nov 20.

From the Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), CHESS Frontier Center, Lanzhou University, Lanzhou, China (Xiaolong Qi); Hepatic Hemodynamic Laboratory, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Xiaolong Qi, Y.L., Chuan Liu, Y.X., J. Hui, Z. Liu, J. Hou); Department of Radiology (W.A., Changchun Liu), Department of General Surgery (R.Q., Z. Li), and Center for Therapeutic Research of Hepatocarcinoma (Y.Y.), 302 Hospital of PLA, Beijing, China; Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China (F.L., L.W.); Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, China (Xingshun Qi); Department of Hepatobiliary Surgery (B.P.) and Organ Transplant Center (X.H.), The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing, China (H.D.); Key Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences, Beijing, China (J.T.); and Department of Hepatobiliary Surgery, The Third People's Hospital of Shenzhen, Shenzhen, China (Z. Li).

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http://dx.doi.org/10.1148/radiol.2018180425DOI Listing
February 2019

Serum Level of Antibodies Against Hepatitis B Core Protein Is Associated With Clinical Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy.

Clin Gastroenterol Hepatol 2019 Jan 11;17(1):182-191.e1. Epub 2018 Jun 11.

Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.05.047DOI Listing
January 2019

Elevated D-dimer is associated with increased 28-day mortality in acute-on-chronic liver failure in China: a retrospective study.

BMC Gastroenterol 2019 Jan 31;19(1):20. Epub 2019 Jan 31.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1186/s12876-019-0941-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357416PMC
January 2019

Improvements in the management of chronic hepatitis B virus infection.

Expert Rev Gastroenterol Hepatol 2018 Nov 5;12(11):1153-1166. Epub 2018 Oct 5.

b Department of Medicine and Therapeutics and Institute of Digestive Disease , The Chinese University of Hong Kong , Hong Kong SAR , China.

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http://dx.doi.org/10.1080/17474124.2018.1530986DOI Listing
November 2018

The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma.

Front Pharmacol 2018 6;9:1298. Epub 2018 Nov 6.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.3389/fphar.2018.01298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232623PMC
November 2018

Development and validation of a radiomics signature for clinically significant portal hypertension in cirrhosis (CHESS1701): a prospective multicenter study.

EBioMedicine 2018 Oct 27;36:151-158. Epub 2018 Sep 27.

CHESS Group, Hepatic Hemodynamic Lab, Institute of Hepatology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China; Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China; CHESS Frontier Center, Lanzhou University, Lanzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197722PMC
October 2018

Targeting cIAPs, a New Option for Functional Cure of Chronic Hepatitis B Infection?

Virol Sin 2018 Oct 29;33(5):459-461. Epub 2018 Oct 29.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

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http://link.springer.com/10.1007/s12250-018-0062-x
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http://dx.doi.org/10.1007/s12250-018-0062-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235761PMC
October 2018

IL-21 receptor signaling is essential for control of hepatocellular carcinoma growth and immunological memory for tumor challenge.

Oncoimmunology 2018 26;7(12):e1500673. Epub 2018 Sep 26.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Hepatology Unit and Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1080/2162402X.2018.1500673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279328PMC
September 2018

Prognostic value of PIVKA-II in hepatocellular carcinoma patients receiving curative ablation: A systematic review and meta-analysis.

Int J Biol Markers 2018 Aug 16;33(3):266-274. Epub 2018 Apr 16.

1 Department of Hepatology Unit and Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.

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http://dx.doi.org/10.1177/1724600818760234DOI Listing
August 2018

Pre-Activation of Toll-Like Receptor 2 Enhances CD8 T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models.

Front Immunol 2018 29;9:1495. Epub 2018 Jun 29.

Department of Microbiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.3389/fimmu.2018.01495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033958PMC
June 2018

Macrophage scavenger receptor 1 contributes to pathogenesis of fulminant hepatitis via neutrophil-mediated complement activation.

J Hepatol 2018 04 14;68(4):733-743. Epub 2017 Nov 14.

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Guangdong Provincial Key Laboratory of Proteomics, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.11.010DOI Listing
April 2018

China Registry of Hepatitis B (CR-HepB): Protocol and implementation of a nationwide hospital-based registry of hepatitis B.

Scand J Public Health 2018 Apr 1:1403494818772188. Epub 2018 Apr 1.

1 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, China.

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http://dx.doi.org/10.1177/1403494818772188DOI Listing
April 2018

Multiple Antigen Stimulating Cellular Therapy (MASCT) For Hepatocellular Carcinoma After Curative Treatment: A Retrospective Study.

J Cancer 2018 6;9(8):1385-1393. Epub 2018 Apr 6.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.7150/jca.23725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929083PMC
April 2018

Effect of hepatitis B virus subgenotype on antiviral response in nucleoside-treated hepatitis B envelope antigen-positive patients.

Hepatol Res 2018 Feb 6;48(2):134-143. Epub 2017 Jun 6.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou.

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http://dx.doi.org/10.1111/hepr.12907DOI Listing
February 2018

Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B.

Hepatol Res 2018 Feb 4;48(3):E213-E221. Epub 2017 Oct 4.

Department of Infectious Diseases, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1111/hepr.12972DOI Listing
February 2018

Sustained immune control in HBeAg-positive patients who switched from entecavir therapy to pegylated interferon-α2a: 1 year follow-up of the OSST study.

Antivir Ther 2016 6;21(4):337-44. Epub 2016 Jan 6.

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.3851/IMP3019DOI Listing
January 2018

Small surface antigen variants of HBV associated with responses to telbivudine treatment in chronic hepatitis B patients.

Antivir Ther 2017 1;22(1):43-51. Epub 2016 Sep 1.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.3851/IMP3078DOI Listing
January 2018

Improving survival of acute-on-chronic liver failure patients complicated with invasive pulmonary aspergillosis.

Sci Rep 2018 01 17;8(1):876. Epub 2018 Jan 17.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/s41598-018-19320-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772638PMC
January 2018

Hepatitis C virus genotypes and subtypes circulating in Mainland China.

Emerg Microbes Infect 2017 Nov 1;6(11):e95. Epub 2017 Nov 1.

Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/emi.2017.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717081PMC
November 2017

Systematic quantification of histological patterns shows accuracy in reflecting cirrhotic remodeling.

J Gastroenterol Hepatol 2017 Sep;32(9):1631-1639

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research; Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://doi.wiley.com/10.1111/jgh.13722
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http://dx.doi.org/10.1111/jgh.13722DOI Listing
September 2017

Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy.

Clin Res Hepatol Gastroenterol 2017 Sep 21;41(4):386-398. Epub 2017 Feb 21.

State key laboratory of organ failure research, Guangdong provincial key laboratory of viral hepatitis research, department of hepatology unit and infectious diseases, Nanfang hospital, Southern medical university, No. 1838, North Guangzhou avenue, 510515 Guangzhou, China; Collaborative innovation center for diagnosis and treatment of infectious diseases, Zhejiang university, Hangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2016.12.006DOI Listing
September 2017

Insufficient accuracy of computed tomography-based portal pressure assessment in hepatitis B virus-related cirrhosis: An analysis of data from CHESS-1601 trial.

J Hepatol 2017 Sep 5. Epub 2017 Sep 5.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.07.037DOI Listing
September 2017

Dynamic Perturbations of CD4 and CD8 T Cell Receptor Repertoires in Chronic Hepatitis B Patients upon Oral Antiviral Therapy.

Front Immunol 2017 14;8:1142. Epub 2017 Sep 14.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.3389/fimmu.2017.01142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603711PMC
September 2017

Lower Expression of MicroRNA-155 Contributes to Dysfunction of Natural Killer Cells in Patients with Chronic Hepatitis B.

Front Immunol 2017 22;8:1173. Epub 2017 Sep 22.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.3389/fimmu.2017.01173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614978PMC
September 2017

The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.

Infect Genet Evol 2017 04 12;49:116-121. Epub 2017 Jan 12.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2017.01.009DOI Listing
April 2017

Evidence for the association between IgG-antimitochondrial antibody and biochemical response to ursodeoxycholic acid treatment in primary biliary cholangitis.

J Gastroenterol Hepatol 2017 Mar;32(3):659-666

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://doi.wiley.com/10.1111/jgh.13534
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http://dx.doi.org/10.1111/jgh.13534DOI Listing
March 2017

Serum Golgi protein 73 is not a suitable diagnostic marker for hepatocellular carcinoma.

Oncotarget 2017 Mar;8(10):16498-16506

Department of Microbiology & Infectious Disease Center, School of Basic Medicine, Peking University Health Science Center, Beijing 100191, P.R. China.

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http://dx.doi.org/10.18632/oncotarget.14954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369980PMC
March 2017

Dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy.

J Transl Med 2017 03 22;15(1):64. Epub 2017 Mar 22.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1186/s12967-017-1165-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363021PMC
March 2017

Elevated Expression of Chemokine CXCL13 in Chronic Hepatitis B Patients Links to Immune Control during Antiviral Therapy.

Front Immunol 2017 23;8:323. Epub 2017 Mar 23.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University , Guangzhou , China.

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http://dx.doi.org/10.3389/fimmu.2017.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362616PMC
March 2017

Optimization of hepatitis B cirrhosis detection by stepwise application of transient elastography and routine biomarkers.

J Gastroenterol Hepatol 2017 Feb;32(2):459-465

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Disease and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://doi.wiley.com/10.1111/jgh.13475
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http://dx.doi.org/10.1111/jgh.13475DOI Listing
February 2017

 Joint Society statement for elimination of viral hepatitis.

Ann Hepatol 2017 Jan-Feb 2017;16(1):6-7

American Association for the Study of Liver Disease.

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http://dx.doi.org/10.5604/16652681.1226808DOI Listing
February 2017

Off-Treatment Hepatitis B Virus (HBV) DNA Levels and the Prediction of Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B: A Prospective Stop Study.

J Infect Dis 2017 02;215(4):581-589

Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1093/infdis/jix025DOI Listing
February 2017

Hepatitis due to Reactivation of Hepatitis B Virus in Endemic Areas Among Patients With Hepatitis C Treated With Direct-acting Antiviral Agents.

Clin Gastroenterol Hepatol 2017 01 5;15(1):132-136. Epub 2016 Jul 5.

Division of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong SAR, China; Second Liver Cirrhosis Diagnosis and Treatment Center, 302 Hospital, Beijing, China; Institute of Translational Hepatology, 302 Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.06.023DOI Listing
January 2017

Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication.

Sci Rep 2017 01 3;7:39901. Epub 2017 Jan 3.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/srep39901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206675PMC
January 2017

Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B.

Sci Rep 2016 11 28;6:37498. Epub 2016 Nov 28.

Liver Research Center, Beijing Friendship Hospital, Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis; National Clinical Research Center for Digestive Disease, Beijing, 100050, China.

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http://dx.doi.org/10.1038/srep37498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124962PMC
November 2016

Response-guided peginterferon therapy in patients with HBeAg-positive chronic hepatitis B: A randomized controlled study.

J Hepatol 2016 10 26;65(4):674-682. Epub 2016 May 26.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.05.024DOI Listing
October 2016

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound.

J Hepatol 2016 10 28;65(4):700-710. Epub 2016 May 28.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.05.029DOI Listing
October 2016

Joint society statement for the elimination of viral hepatitis.

Hepatology 2016 10 1;64(4):1031-2. Epub 2016 Aug 1.

American Association for the Study of Liver Disease.

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http://dx.doi.org/10.1002/hep.28730DOI Listing
October 2016

Joint society statement for the elimination of viral hepatitis.

J Hepatol 2016 10 1;65(4):661-662. Epub 2016 Aug 1.

American Association for the Study of Liver Disease.

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http://dx.doi.org/10.1016/j.jhep.2016.07.015DOI Listing
October 2016

A hepatitis B-free generation in China: from dream to reality.

Lancet Infect Dis 2016 10 19;16(10):1103-1105. Epub 2016 Sep 19.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(16)30327-9DOI Listing
October 2016

Prevention of Peripartum Hepatitis B Transmission.

N Engl J Med 2016 10;375(15):1496

Nanfang Hospital, Guangzhou, China

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http://dx.doi.org/10.1056/NEJMc1609991DOI Listing
October 2016

Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.

Lancet Gastroenterol Hepatol 2016 10 25;1(2):97-104. Epub 2016 Jul 25.

Division of Gastroenterology and Hepatology, Humanity and Health Medical Centre, Hong Kong, Hong Kong SAR, China (Prof G Lau MD, C Wang MD, J Chen PhD, V Wu BSc, A Wong BSc, Y Wang PhD); Second Liver Cirrhosis Diagnosis and Treatment Center (Prof G Lau, Prof G Chen MD, Prof Q Shao MD, D Ji MD, F Li MD, B Li MD, J Liu MD) and Institute of Infectious Disease (Prof J Li MD), 302 Hospital, Beijing, China; Service d'Hépatologie, Hôpital Pitié-Salpêtrière, Paris, France (Y Benhamou MD); State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China (Prof J Hou MD, Prof J Sun MD, C Wang); Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong SAR, China (C L P Wong PhD, S T Y Tsang PhD); Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA (L Bassit PhD, S Tao PhD, Y Jiang PhD, H-M Hsiao MS, Prof R F Schinazi PhD); Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM, USA (R Ke PhD, A S Perelson PhD); and Department of Mathematics, North Carolina State University, Raleigh, NC, USA (R Ke).

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http://dx.doi.org/10.1016/S2468-1253(16)30015-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131925PMC
October 2016

Upregulation of NKG2C+ natural killer cells, TLR-2 expression on monocytes and downregulation of regulatory T-cells influence PEG-IFN treatment efficacy in entecavir-suppressed patients with CHB.

Antivir Ther 2015 27;20(6):591-602. Epub 2015 Mar 27.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.3851/IMP2953DOI Listing
September 2016

Naturally occurring deletions/insertions in HBV core promoter tend to decrease in hepatitis B e antigen-positive chronic hepatitis B patients during antiviral therapy.

Antivir Ther 2015 2;20(6):623-32. Epub 2015 Apr 2.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.3851/IMP2955DOI Listing
September 2016

Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.

PLoS One 2015 28;10(12):e0144425. Epub 2015 Dec 28.

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144425PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692502PMC
August 2016

Joint Society Statement for elimination of viral hepatitis.

Ann Hepatol 2017 Jan - Feb;16(1):6-7

American Association for the Study of Liver Disease.

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http://dx.doi.org/10.5604/16652681.1226808DOI Listing
August 2016

Combination Therapy With Tenofovir and Peginterferon May Not Be Translated Into Current Clinical Practice.

Gastroenterology 2016 05 26;150(5):1253-1254. Epub 2016 Mar 26.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou.

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http://dx.doi.org/10.1053/j.gastro.2015.12.046DOI Listing
May 2016

Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.

Gut 2016 Feb 13;65(2):313-20. Epub 2015 Jan 13.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.

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http://gut.bmj.com/content/early/2015/01/13/gutjnl-2014-3085
Web Search
http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2014-308546
Publisher Site
http://dx.doi.org/10.1136/gutjnl-2014-308546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752655PMC
February 2016

[Establishment of a diet-induced obesity model in zebrafish larvae].

Nan Fang Yi Ke Da Xue Xue Bao 2016 Jan;36(1):20-5

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Guangzhou 510515, China.E-mail:

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January 2016

Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae.

J Biomed Sci 2015 Nov 17;22:105. Epub 2015 Nov 17.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

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http://dx.doi.org/10.1186/s12929-015-0206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647812PMC
November 2015

High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs.

Nutr Metab (Lond) 2015 14;12:42. Epub 2015 Nov 14.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key, Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 China.

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http://dx.doi.org/10.1186/s12986-015-0036-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650307PMC
November 2015

Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy.

Sci Rep 2015 Nov 24;5:17123. Epub 2015 Nov 24.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/srep17123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657086PMC
November 2015

[The efficacy and prognostic predictors of different treatment courses with pegylated interferon α-2a and ribavirin combination in recurrent chronic hepatitis C patients].

Zhonghua Nei Ke Za Zhi 2015 Aug;54(8):699-704

Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044, China; Email:

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August 2015

Naturally occurring deletion/insertion mutations within HBV whole genome sequences in HBeAg-positive chronic hepatitis B patients are correlated with baseline serum HBsAg and HBeAg levels and might predict a shorter interval to HBeAg loss and seroconversion during antiviral treatment.

Infect Genet Evol 2015 Jul 12;33:261-8. Epub 2015 May 12.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15671348150017
Publisher Site
http://dx.doi.org/10.1016/j.meegid.2015.05.013DOI Listing
July 2015

Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis.

Hepatology 2015 Jun 18;61(6):1998-2007. Epub 2015 Mar 18.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1002/hep.27725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441570PMC
June 2015

Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy.

Antiviral Res 2015 Jun 12;118:10-9. Epub 2015 Mar 12.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.03.004DOI Listing
June 2015

Role of interleukin-21 in HBV infection: friend or foe?

Cell Mol Immunol 2015 May 3;12(3):303-8. Epub 2014 Nov 3.

1] Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China [2] State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, China [3] Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.1038/cmi.2014.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654311PMC
May 2015

Randomized, three-arm study to optimize lamivudine efficacy in hepatitis B e antigen-positive chronic hepatitis B patients.

J Gastroenterol Hepatol 2015 Apr;30(4):748-55

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1111/jgh.12835DOI Listing
April 2015

Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B.

J Gastroenterol Hepatol 2015 Apr;30(4):756-62

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China.

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http://dx.doi.org/10.1111/jgh.12840DOI Listing
April 2015

[Diagnose the regression of liver fibrosis and cirrhosis].

Zhonghua Gan Zang Bing Za Zhi 2015 Apr;23(4):244-6

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April 2015

Association between vitamin D level and viral load or fibrosis stage in chronic hepatitis B patients from Southern China.

J Gastroenterol Hepatol 2015 Mar;30(3):566-74

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1111/jgh.12783DOI Listing
March 2015

Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells.

Mol Med Rep 2015 Jan 22;11(1):712-8. Epub 2014 Oct 22.

State Key Labaoratory of Biotherapy, Section of Oncogene, Chengdu, Sichuan 610041, P.R. China.

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http://dx.doi.org/10.3892/mmr.2014.2736DOI Listing
January 2015

[Relationship between hepatitis B virus polymerase gene mutation patterns of rtM204I/V and pre-core/basal core promoter mutations].

Zhonghua Gan Zang Bing Za Zhi 2014 Dec;22(12):891-4

Department of Liver Center, Shanghai Public Health Clinical Center, Shanghai 200083, China.

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2014.12.003DOI Listing
December 2014

TCRγδ(+)CD4(-)CD8(-) T cells suppress the CD8(+) T-cell response to hepatitis B virus peptides, and are associated with viral control in chronic hepatitis B.

PLoS One 2014 14;9(2):e88475. Epub 2014 Feb 14.

Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088475PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925121PMC
October 2014

[Identification of hepatitis B virus intergenotype recombination in Chinese patients].

Nan Fang Yi Ke Da Xue Xue Bao 2014 Oct;34(10):1436-42

Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail:

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October 2014

Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.

Hepatol Int 2014 Oct 31;8(4):508-16. Epub 2014 Jul 31.

Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

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http://dx.doi.org/10.1007/s12072-014-9554-4DOI Listing
October 2014

Current challenges and the management of chronic hepatitis C in mainland China.

J Clin Gastroenterol 2014 Sep;48(8):679-86

*Artificial Liver Center, Beijing Youan Hospital †Division of Hepatology, Friendship Hospital, Capital Medical University ¶Department of Infectious Diseases, Peking University First Hospital #Hepatology Institute, Peking University People's Hospital **Department of Microbiology and Center of Infectious Disease, School of Basic Medicine, Peking University Health Science Center, Peking University, Beijing ‡Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China §Hepatitis Consulting at Nexus Development, Palo Alto, CA ∥Department of Medicine, Division of Gastroenterology, NYU Langone Medical Center, NYU School of Medicine, New York, NY.

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http://dx.doi.org/10.1097/MCG.0000000000000109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162325PMC
September 2014

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China.

Front Med 2014 Jun 8;8(2):135-44. Epub 2014 May 8.

Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

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http://dx.doi.org/10.1007/s11684-014-0331-5DOI Listing
June 2014

[Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish].

Nan Fang Yi Ke Da Xue Xue Bao 2014 Jun;34(6):777-82

Department of Infectious Diseases and Hepatology Unit, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail:

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June 2014

Mannan binding lectin attenuates double-stranded RNA-mediated TLR3 activation and innate immunity.

FEBS Lett 2014 Mar 11;588(6):866-72. Epub 2014 Feb 11.

Department of Immunology, Southern Medical University, Guangzhou 510515, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.01.064DOI Listing
March 2014