Publications by authors named "Jinliang Hu"

15 Publications

  • Page 1 of 1

Comparison Between Cyanoacrylate Embolization and Radiofrequency Ablation for Superficial Venous Incompetence: A Systematic Review and Meta-analysis.

Dermatol Surg 2021 Apr 22. Epub 2021 Apr 22.

Department of Dermatology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China; Department of Dermatology, Ya'an Polytechnic College Affiliated Hospital, Ya'an, China; Institute of Health Policy and Hospital Management, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

Background: Chronic venous disease is a debilitating condition involving great saphenous vein (GSV) incompetence.

Objective: To investigate the efficacy and effectiveness of cyanoacrylate embolization (CAE) versus radiofrequency ablation (RFA) in patients with incompetent GSVs.

Materials And Methods: PubMed, Embase, and the Cochrane library were searched. The primary outcomes were the Venous Clinical Severity Score (VCSS), Aberdeen Varicose Vein Questionnaire (AVVQ), closure rate, and visual analog scale (VAS) for pain.

Results: This meta-analysis included 378 and 590 patients who underwent CAE and RFA, respectively. Cyanoacrylate embolization was comparable with RFA in VCSS (weighted mean difference [WMD] = -0.03, 95% confidence interval [CI]: -0.18 to 0.12, p = .686), AVVQ (WMD = -0.08, 95% CI: -0.38 to 0.21, p = .570), closure rate (odds ratio [OR] = 0.61, 95% CI: 0.18-2.01, p = .414), and VAS (standardized mean difference [SMD] = 0.24, 95% CI: -0.59 to 1.06, p = .523). There were no significant differences between CAE and RFA regarding the occurrence of phlebitis (OR = 1.22, 95% CI: 0.70-2.13, p = .479) and pigmentation (OR = 0.48, 95% CI: 0.18-1.31, p = .153), but CAE had a lower risk of ecchymosis (OR = 0.45, 95% CI: 0.25-0.81, p = .007) and paresthesia (OR = 0.16, 95% CI: 0.03-0.99, p = .049).

Conclusion: Cyanoacrylate embolization and RFA demonstrated no significant differences in VCSS, AVVQ, closure rate, and pain score for patients with incompetent GSVs. Patients in the CAE group had a lower risk of ecchymosis and paresthesia compared with the RFA group.
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http://dx.doi.org/10.1097/DSS.0000000000003061DOI Listing
April 2021

Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study.

Epidemiol Infect 2021 04 12;149:e95. Epub 2021 Apr 12.

Institute of Health Policy & Hospital Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervical cytology test at the gynaecological clinic, West China Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients (20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes. The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%), HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases, 14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different diagnoses in patients with positive cervical cytological findings.
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http://dx.doi.org/10.1017/S0950268821000741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080181PMC
April 2021

In vitro anti-mycobacterial activity of novel benzo(c)thiophene-1,3-dione: A novel scaffold against Mycobacterium tuberculosis.

Microb Pathog 2020 Nov 29;148:104466. Epub 2020 Aug 29.

Department of Medical Laboratory, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Brith Defects of Ministry of Education, Chengdu, Sichuan, 610041, China.

Tuberculosis (TB) an infectious disease with very high mortality claims approximately 1.5 million lives and infects 2 billion people annually. The present study evaluated anti-tuberculosis activity of benzo(c)thiophene-1,3-dione against Mycobacterial tuberculosis H37RV in vitro and in vivo in tuberculosis mice model. The MIC of benzo(c)thiophene-1,3-dione, rifampicin and isoniazid were found to be 4.0, 2.0 and 1.0 μg/ml, respectively. Benzo(c)thiophene-1,3-dione showed MIC in the range of 8-14 μg/ml against four drug-resistant isolates of M. tuberculosis and MBC 14 μg/ml against M. tuberculosis H37RV. Interaction of benzo(c)thiophene-1,3-dione with rifampicin led to 2-fold increase in anti-TB activity whereas with isoniazid improvement showed 4-fold enhancement. Fractional inhibitor concentration index suggested additive interaction with rifampicin and synergism with isoniazid. Treatment with benzo(c)thiophene-1,3-dione at 1X MIC indicated bacteriostatic activity whereas at 2X, 4X and 4X MIC doses significant reduction in M. tuberculosis load was observed. The benzo(c)thiophene-1,3-dione administration to mice at doses of 5000 and 1000 mg/kg caused no changes in behaviour nor any death. Benzo(c)thiophene-1,3-dione treatment of tuberculosis mice model effectively inhibited pulmonary CFU compared to model group. Data obtained from MTT assay showed negligible cytotoxicity of benzo(c)thiophene-1,3-dione against CMMT, MB 157, CL-S1, normal breast cells in 5-320 μg/ml concentration range. Thus, benzo(c)thiophene-1,3-dione exhibits promising anti-mycobacterial activity against Mycobacterium tuberculosis H37RV and other drug resistant strains. In Mycobacterium tuberculosis mice model benzo(c)thiophene-1,3-dione significantly suppressed bacterial load and showed synergism with isoniazid. Therefore, benzo(c)thiophene-1,3-dione has potential to be evaluated further for development of anti-tuberculosis treatment.
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http://dx.doi.org/10.1016/j.micpath.2020.104466DOI Listing
November 2020

Hyperboloid-Drum Microdisk Laser Biosensors for Ultrasensitive Detection of Human IgG.

Small 2020 07 8;16(26):e2000239. Epub 2020 Jun 8.

Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra Precision Optical Manufacturing, Fudan University, Shanghai, 200433, China.

Whispering gallery mode (WGM) microresonators have been used as optical sensors in fundamental research and practical applications. The majority of WGM sensors are passive resonators that require complex systems, thereby limiting their practicality. Active resonators enable the remote excitation and collection of WGM-modulated fluorescence spectra, without requiring complex systems, and can be used as alternatives to passive microresonators. This paper demonstrates an active microresonator, which is a microdisk laser in a hyperboloid-drum (HD) shape. The HD microdisk lasers are a combination of a rhodamine B-doped photoresist and a silica microdisk. These HD microdisk lasers can be utilized for the detection of label-free biomolecules. The biomolecule concentration can be as low as 1 ag mL , whereas the theoretical detection limit of the biosensor for human IgG in phosphate buffer saline is 9 ag mL (0.06 a ). Additionally, the biosensors are able to detect biomolecules in an artificial serum, with a theoretical detection limit of 9 ag mL (0.06 a ). These results are approximately four orders of magnitude more sensitive than those for the typical active WGM biosensors. The proposed HD microdisk laser biosensors show enormous detection potential for biomarkers in protein secretions or body fluids.
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http://dx.doi.org/10.1002/smll.202000239DOI Listing
July 2020

Comparison of clinical and epidemiological characteristics of asymptomatic and symptomatic SARS-CoV-2 infection: A multi-center study in Sichuan Province, China.

Travel Med Infect Dis 2020 Sep - Oct;37:101754. Epub 2020 May 31.

Department of Radiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 610072, China.

Objectives: Asymptomatic infection of SARS-CoV-2 has become a concern worldwide. This study aims to compare the epidemiology and the clinical characteristics of SARS-CoV-2 infection in asymptomatic and symptomatic individuals.

Methods: A total of 511 confirmed SARS-CoV-2 infection cases, including 100 asymptomatic (by the time of the pathogenic tests) and 411 symptomatic individuals were consecutively enrolled from January 25 to February 20, 2020 from hospitals in 21 cities and 47 counties or districts in Sichuan Province. Epidemiological and clinical characteristics were compared.

Results: Compared to the symptomatic patients, the asymptomatic cases were younger (P < 0.001), had similar co-morbidity percentages (P = 0.609), and came from higher altitude areas with lower population mobility (P < 0.001) with better defined epidemiological history (P < 0.001). 27.4% of well-documented asymptomatic cases developed delayed symptoms after the pathogenic diagnosis. 60% of asymptomatic cases demonstrated findings of pneumonia on the initial chest CT, including well-recognized features of coronavirus disease-19. None of the asymptomatic individuals died. Two elderly individuals with initially asymptomatic infection developed severe symptoms during hospitalization. One case of possible virus transmission by a patient during the incubation period was highly suspected.

Conclusions: The epidemiological and clinical findings highlight the significance of asymptomatic infection with SARS-CoV-2. Inspecting the epidemiological history would facilitate the identification of asymptomatic cases. Evidence supports the chest CT scans for confirmed asymptomatic cases to evaluate the extent of lung involvement.
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http://dx.doi.org/10.1016/j.tmaid.2020.101754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833588PMC
October 2020

Activating transcription factor 6 regulated cell growth, migration and inhibiteds cell apoptosis and autophagy via MAPK pathway in cervical cancer.

J Reprod Immunol 2020 06 15;139:103120. Epub 2020 Mar 15.

Institute of Health Policy & Hospital Management, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan Province, China; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Background: Cervical cancer cell function is influence by ER. Therefore, in this study, ER stress senser-ATF6, was selected for detailed research in cervical cancer.

Methods: ATF6 mRNA was assessed through RT-qPCR assays. Cell transfection was to regulate ATF6 and thereafter the differential ATF6 cancer cells were divided into two groups for further functional assays. Cell viabilities were analyzed by CCK-8 and migration by Scratch. RT-qPCR examined cell death biomarkers Caspas-3 and Bcl-2. 4-PBA was utilized to inhibit ER stress. After that, ATF6, viability, migration and apoptotic proteins were scrutinized after ER inhibition. Proteins signifying EMT, autophagy and MAPK signaling pathway were checked by western bolt. Last, we inactivated the MAPK signaling to investigate into the changes in cell functions.

Results: ATF6 presented higher expression in cervical cancer cells. Inhibited ATF6 could reduce cell viabilities and migration but promote apoptosis through suppressing Bcl-2 and increasing caspase-3. ER stress antagonist witnessed a drop in ATF6 expression, cell viability, migration and Bcl-2 but a rise in caspase-3 activation, suggesting apoptosis increase. Cell autophagy was hindered in CC cells. Knockdown of ATF6 promoted autophagy and restrained EMT and MAPK signaling pathway. Suppressed ERK1/2 obstructed cell viabilities, migration, EMT and autophagy but promoted apoptosis.

Conclusion: ATF6 might promote cell growth, migration, autophagy through ER stress and MAPK signaling in cervical cancer in vitro, indicating a potential regulatory gene in cervical cancer. However, in-depth researches are requested to enrich the knowledge of ATF6 in cervical cancer in vivo and in clinical in the future.
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http://dx.doi.org/10.1016/j.jri.2020.103120DOI Listing
June 2020

Spectral Modulation of Optofluidic Coupled-Microdisk Lasers in Aqueous Media.

Nanomaterials (Basel) 2019 Oct 11;9(10). Epub 2019 Oct 11.

Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra Precision Optical Manufacturing, Fudan University, Shanghai 200433, China.

We present the spectral modulation of an optofluidic microdisk device and investigate the mechanism and characteristics of the microdisk laser in aqueous media. The optofluidic microdisk device combines a solid-state dye-doped polymer microdisk with a microfluidic channel device, whose optical field can interact with the aqueous media. Interesting phenomena, such as mode splitting and single-mode lasing in the laser spectrum, can be observed in two coupled microdisks under the pump laser. We modulated the spectra by changing the gap of the two coupled microdisks, the refractive indices of the aqueous media, and the position of a pump light, namely, selective pumping schemes. This optofluidic microlaser provides a method to modulate the laser spectra precisely and flexibly, which will help to further understand spectral properties of coupled microcavity laser systems and develop potential applications in photobiology and photomedicine.
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http://dx.doi.org/10.3390/nano9101439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835252PMC
October 2019

The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis.

Clin Rheumatol 2019 Dec 2;38(12):3595-3607. Epub 2019 Aug 2.

Academic Rheumatology, Division of Rheumatology, Orthopedics and Dermatology, School of Medicine, Nottingham City Hospital, University of Nottingham, Room A18, Hucknall Road, Nottingham, NG5 1PB, UK.

Objectives: This study aims to evaluate the efficacy of treatments for Kashin-Beck disease (KBD).

Method: We searched PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, SinoMed, Chinese National Knowledge Infrastructure, reference lists and published systematic reviews and registries of ongoing trials through May 2015 for randomised controlled trials (RCTs) of treatments for KBD. Outcomes of interest were pain, function, stiffness, overall clinical improvement, radiographic improvement (X-ray) and adverse events. Frequentist network meta-analyses were conducted using random-effects consistency model to assess the efficacy of treatments for KBD.

Results: Forty-four RCTs with 9815 participants were included in the review. In children or adolescents, selenium (risk ratio 1.88, 95% confidence interval (CI) 1.51-2.33), vitamin C (2.03, 1.40-2.95) and aspirin (2.14, 1.12-4.08) were effective for radiographic structure improvement. In adults, chondroitin plus glucosamine was the best for pain (standardised mean difference 1.46, 95% CI 1.07-1.85), followed by intra-articular injection of hyaluronic acid (IAH) (1.09, 0.70-1.48), chondroitin (0.84, 0.47-1.21), diclofenac (0.63, 1.18-1.08), naproxen (0.55, 0.12-0.98), meloxicam (0.52, 0.03-1.01) and glucosamine (0.40, 0.13-0.67) compared to placebo, with similar results for other clinical outcomes in adults. However, the strength of most evidence was limited by the small number of trials with low to moderate quality.

Conclusions: Selenium supplement has demonstrated some benefits for structural improvement of the disease in children. Chondroitin, glucosamine, IAH and nonsteroid anti-inflammatory drugs are effective for symptom improvements of KBD in adults. Evidence of surgical and complementary treatments for symptoms and aspirin and vitamin C for structure has yet to be established.Key Points• There were 23 nutraceuticals, pharmaceuticals and surgical and complementary treatments assessed for Kashin-Beck disease (KBD) in randomised trials.• Among the 23 treatments, chondroitin, glucosamine, IAH and non-steroid anti-inflammatory drugs are more effective than placebo to relieve symptoms for adults with KBD.• Selenium supplement is more effective than placebo for radiographic improvement in children or adolescents.• The efficacy of surgeries, aspirin, vitamin C and complementary treatments for KBD has not been established yet.
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http://dx.doi.org/10.1007/s10067-019-04704-0DOI Listing
December 2019

Orthogonal Demodulation Pound-Drever-Hall Technique for Ultra-Low Detection Limit Pressure Sensing.

Sensors (Basel) 2019 Jul 22;19(14). Epub 2019 Jul 22.

Key Lab for Micro and Nanophotonic Structures (Ministry of Education), Department of Optical Science and Engineering, School of Information Science and Engineering, Fudan University, Shanghai 200433, China.

We report on a novel optical microcavity sensing scheme by using the orthogonal demodulation Pound-Drever-Hall (PDH) technique. We found that larger sensitivity in a broad range of cavity quality factor (Q) could be obtained. Taking microbubble resonator (MBR) pressure sensing as an example, a lower detection limit than the conventional wavelength shift detection method was achieved. When the MBR cavity Q is about 10-10, the technique can decrease the detection limit by one or two orders of magnitude. The pressure-frequency sensitivity is 11.6 GHz/bar at wavelength of 850 nm, and its detection limit can approach 0.0515 mbar. This technique can also be applied to other kinds of microcavity sensors to improve sensing performance.
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http://dx.doi.org/10.3390/s19143223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679526PMC
July 2019

Prevalence of human T-cell lymphotropic virus type-1 infection among blood donors in mainland China: a systematic review and meta-analysis of the last 20 years.

Expert Rev Hematol 2019 08 26;12(8):579-587. Epub 2019 Jun 26.

d Institute of Health Policy & Hospital Management, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital , Chengdu , China.

: The southeastern coastal area of China has a high prevalence of HTLV-1 infection among blood donors. However, the estimation of HTLV-1 prevalence on a national and regional level is little known. The aim of this study is to understand and explore the estimation of HTLV-1 infection prevalence among blood donors on a national and regional level in mainland China by using a systematic review and meta-analysis. : All relevant publications of the past two decades (1998-2017), which were reported in both English and Chinese languages, were adopted and systematically assessed. The estimation of prevalence and its 95% confidence interval (CI) at the level of provinces/municipalities and overall were estimated using meta-analysis method. : From the 327 studies searched, 60 met the inclusion criteria. These were from 18 provinces and four municipalities and included 1,420,079 blood donors. The overall estimation of the HTLV-1 prevalence in blood donors was 0.169‰, and its 95% CI was 0.121‰-0.240‰. : A disproportionate distribution of HTLV-1 infection among blood donors in different provinces/municipalities regarding its prevalence has been reported. This study recommends developing appropriate HTLV-1 screening strategies of blood donors in various regions of China considering regional prevalence, and cost-effectiveness.
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http://dx.doi.org/10.1080/17474086.2019.1632703DOI Listing
August 2019

Syntheses and Properties of meso-Substituted Porphyrin Mesogens with Triazole Linkages and Peripheral Alkyl Chains.

Chem Asian J 2018 Mar 6;13(5):536-544. Epub 2018 Feb 6.

Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Chemistry School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P.R. China.

Discotic mesogens P/n-M (n=12, 16, 18, M=2 H, Zn and Cu) bearing a porphyrin core, triazole linkages and peripheral 3,4,5-trialkoxybenzyl units have been synthesized by a click-chemistry approach. The thermal behavior, photophysical properties and morphologies of these compounds were investigated by polarized optical microscopy (POM), differential scanning calorimetry (DSC), XRD, UV and PL, SEM and TEM. These compounds can self-assemble into hexagonal columnar phases in their pure states and form organogels in 1,4-dioxane with unusually flower-like sphere morphology. The supramolecular complexes of P/18-Zn with C or 4,7-di-4-pydriyl-2,1,3-benzothadiazole can display hexagonal columnar phases too. Additionally, zinc porphyrin compounds P/n-Zn show binding selectivity to Cu among a series of cations in THF/H O.
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http://dx.doi.org/10.1002/asia.201701666DOI Listing
March 2018

A multi-slice sliding cell technique for diffusion measurements in liquid metals.

Rev Sci Instrum 2017 Sep;88(9):093905

School of Materials Science and Engineering and Anhui Provincial Key Lab of Advanced Functional Materials and Devices, Institute of Amorphous Matter Science, Hefei University of Technology, Hefei 230009, People's Republic of China.

The long capillary and shear-cell techniques are traditionally used for diffusion measurements in liquid metals. Inspired by the idea of the shear-cell method, we have built a multi-slice sliding cell device for inter-diffusion measurements in liquid metals. The device is designed based on a linear sliding movement rather than a rotational shearing as used in the traditional shear-cell method. Compared with the normal shear-cell method, the present device is a more compact setup thus easier to handle. Also, it is expected to be easier to monitor with X-rays or neutrons if used in in situ experiments. A series of benchmark time-dependent diffusion experiments in Al-Cu melts carried out with the present technique reveal that accurate diffusion constants can be achieved only after a sufficient time. For short annealing times, the initial shearing process causing convective flow dominates the measurement and leads to an increase of the measured diffusion coefficient by a factor three. The diffusion data obtained for Al-Cu liquids are consistent with the most accurate data measured by the in situ X-ray radiography method under well controlled conditions of no temperature gradient or other perturbation. High accuracy and easy handling as well as superior adaptability make the present technique suitable for diffusion studies in liquid metals.
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http://dx.doi.org/10.1063/1.5003623DOI Listing
September 2017

Association between hOGG1 polymorphism rs1052133 and gastric cancer.

Oncotarget 2017 May;8(21):34321-34329

Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.

Purpose: To conduct a comprehensive evaluation of the association of the human8-oxoguanine glycosylase 1 (hOGG1) gene polymorphism rs1052133 with gastric cancer (GC) through a systematic review and meta-analysis of genetic association study.

Results: A total of 15 articles from published papers were included in our analysis. The meta-analyses for hOGG1 rs1052133, composed of 4024GC patients and 6022controls, showed low heterogeneity for the included populations in all the genetic models, except for the Caucasian population under allelic genetic model, the Asian population under addictive model and Caucasian population under dominant model. The analyses of all the genetic models in overall pooled populations did not identify any significant association between GC and hOGG1 rs1052133 (Allelic model: C vs. G , p = 0.746; Addictive model: CC vs. GG, p = 0.888; Recessive model: CC +GC vs. GG, p = 0.628; Dominant model: CC vs. GG+GC, p = 0.147), even though stratified analyses were conducted in different ethnicities under each genetic model.

Materials And Methods: All case-control association studies on hOGG1 and GC reported up to December 15, 2016 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for single-nucleotide polymorphism (SNP) using fixed- and random- effects models according to between-study heterogeneity. Publication bias analyses were conducted using Begg test.

Conclusions: This meta-analysis showed there was no association between hOGG1 rs1052133 and GC. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.
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http://dx.doi.org/10.18632/oncotarget.16124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470970PMC
May 2017

Association of IGF1 polymorphism rs6214 with high myopia: A systematic review and meta-analysis.

Ophthalmic Genet 2017 Sep-Oct;38(5):434-439. Epub 2017 Jan 31.

a Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , Chengdu , Sichuan , China.

Purpose: To conduct a comprehensive evaluation of the association of Insulin-like growth factor 1 (IGF1) polymorphism rs6214 with high myopia through a systematic review and meta-analysis of candidate genetic association study.

Methods: All case-control association studies on IGF1 and high myopia reported up to 15 June 2016 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for single-nucleotide polymorphism (SNP) using fixed and random effects models according to between study heterogeneity. Publication bias analyses were conducted using Begg's test.

Results: A total of eight studies from published articles were included in our analysis. The meta-analyses for IGF1 rs6214, composed of 4242 high myopia patients and 4430 controls, showed low heterogeneity for the included populations in all the genetic models, except that of the allelic genetic model in the pooled populations. The analyses of all the genetic models in Chinese, Japanese, and overall pooled populations did not identify any significant association between high myopia and IGF1 rs6214.

Conclusions: This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.
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http://dx.doi.org/10.1080/13816810.2016.1253105DOI Listing
December 2017

Distribution of D9S2150, GATA164F07, and D10S2469 alleles in a Chinese population sample.

J Forensic Sci 2006 Mar;51(2):448-9

Institute of Forensic Medicine, West China Medical Center, Sichuan University, Chengdu 610041, Sichuan, China.

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http://dx.doi.org/10.1111/j.1556-4029.2006.00095.xDOI Listing
March 2006
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