Publications by authors named "Jinhui Li"

311 Publications

Study on the Clinical Significance of ACE2 and Its Age-Related Expression.

J Inflamm Res 2021 30;14:2873-2882. Epub 2021 Jun 30.

Department of Emergency/Critical care Medicine, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210008, People's Republic of China.

Background: ACE2 plays a particular role in the changes in multiple organ functions. However, whether ACE2 expression differs at different ages and whether it plays a role in infection-related organ dysfunction remains unclear.

Methods: Female and male C57BL/6 mice in four different age groups were included in this study. Immunohistochemical and Western blot analyses were performed to evaluate ACE2 expression characteristics in lung tissues. At the same time, we detected the changes of ACE2 in human blood of different ages and evaluated its clinical significance in sepsis-associated organ dysfunction (SAOD).

Results: This study indicated that ACE2 is expressed differently in mouse lung tissues at four different ages (P < 0.05). The peak expression distribution of ACE2 in lung tissues was in the newborn and middle-aged cohorts (P < 0.05). Infants younger than one year had a significantly higher concentration of ACE2 in serum and enhanced susceptibility compared with other ages (P < 0.05). Serum APTT, D-dimer, LDH, and PCT, as well as ACE2 in sepsis and SAOD groups, were statistically significant (P < 0.05) and were related to an increased risk of SAOD. There was a positive correlation between ACE2 and D-dimer (P < 0.05).

Conclusion: The levels of ACE2 expression varied in different age groups. It tends to be higher in infants and young children. This result suggests that young children are more susceptible to infection. Moreover, a cutoff value for the ACE2 level >1551.15 pg/mL and D-dimer >984.5 U/L should be considered a warning sign of infection-associated organ dysfunction and guide the clinician in evaluating the patient's multiple organ function.
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http://dx.doi.org/10.2147/JIR.S315981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256825PMC
June 2021

Selective Complex Precipitation for Ferro-Chrome Separation From Electroplating Sludge Leaching Solution.

Front Chem 2021 16;9:592407. Epub 2021 Jun 16.

School of Metallurgy and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou, China.

In this paper, aiming at the problem of chrome-iron separation in electroplating sludge, the separation of ferrochrome by complexation and precipitation with benzoic acid as complexing agent is achieved. The optimal conditions consisted of a 1: 3 molar ratio of Fe: CHCOOH, a reaction temperature of 30°C, a final pH of 2.5 and a reaction time of 2 min. The separation rate of the iron was 97.38% and the rate of loss of chromium was only 3.59%. The ferrochromium separation products were analyzed by XRD, fluorescence spectroscopy, infrared spectroscopy and H NMR Spectroscopy in order to study the mechanism of precipitation. The results showed that benzoic acid preferentially forms a complex with iron and iron benzoate precipitates with an increase pH. The iron benzoate crystals have a fine particle size, settle rapidly and are easy to filter. The separation of Cr /Fe was successful using our methodology.
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http://dx.doi.org/10.3389/fchem.2021.592407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241916PMC
June 2021

Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.

Nucleic Acids Res 2021 07;49(12):6788-6803

Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.

Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high genomic instability, but the underlying mechanisms causing this phenotype are still largely unknown. Here, we report that upon DNA damage, SPOP is phosphorylated at Ser119 by the ATM serine/threonine kinase, which potentiates the binding of SPOP to homeodomain-interacting protein kinase 2 (HIPK2), resulting in a nondegradative ubiquitination of HIPK2. This modification subsequently increases the phosphorylation activity of HIPK2 toward HP1γ, and then promotes the dissociation of HP1γ from trimethylated (Lys9) histone H3 (H3K9me3) to initiate DNA damage repair. Moreover, the effect of SPOP on the HIPK2-HP1γ axis is abrogated by prostate cancer-associated SPOP mutations. Our findings provide new insights into the molecular mechanism of SPOP mutations-driven genomic instability in prostate cancer.
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http://dx.doi.org/10.1093/nar/gkab489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266658PMC
July 2021

Human spatial navigation: Neural representations of spatial scales and reference frames obtained from an ALE meta-analysis.

Neuroimage 2021 Sep 12;238:118264. Epub 2021 Jun 12.

Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, Guangdong, 510631, China. Electronic address:

Humans use different spatial reference frames (allocentric or egocentric) to navigate successfully toward their destination in different spatial scale spaces (environmental or vista). However, it remains unclear how the brain represents different spatial scales and different spatial reference frames. Thus, we conducted an activation likelihood estimation (ALE) meta-analysis of 47 fMRI articles involving human spatial navigation. We found that both the environmental and vista spaces activated the parahippocampal place area (PPA), retrosplenial complex (RSC), and occipital place area in the right hemisphere. The environmental space showed stronger activation than the vista space in the occipital and frontal regions. No brain region exhibited stronger activation for the vista than the environmental space. The allocentric and egocentric reference frames activated the bilateral PPA and right RSC. The allocentric frame showed more stronger activations than the egocentric frame in the right culmen, left middle frontal gyrus, and precuneus. No brain region displayed stronger activation for the egocentric than the allocentric navigation. Our findings suggest that navigation in different spatial scale spaces can evoke specific and common brain regions, and that the brain regions representing spatial reference frames are not absolutely separated.
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http://dx.doi.org/10.1016/j.neuroimage.2021.118264DOI Listing
September 2021

Metagenomic diagnosis of severe psittacosis using multiple sequencing platforms.

BMC Genomics 2021 Jun 2;22(1):406. Epub 2021 Jun 2.

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, 100071, Beijing, China.

Background: Chlamydia psittaci is an avian pathogen that can cause lethal human infections. Diagnosis of C. psittaci pneumonia is often delayed due to nonspecific clinical presentations and limited laboratory diagnostic techniques.

Results: The MinION platform established the diagnosis in the shortest time, while BGISEQ-500 generated additional in-depth sequence data that included the rapid characterization of antibiotic susceptibility. Cytopathy appeared only in cell cultures of BALF. BALF yielded a higher bacterial load than sputum or blood, and may be the most suitable clinical specimen for the genomic diagnosis of severe pneumonia.

Conclusions: This study indicated that the benefits of metagenomic sequencing include rapid etiologic diagnosis of unknown infections and the provision of additional relevant information regarding antibiotic susceptibility. The continued optimization and standardization of sampling and metagenomic analysis promise to enhance the clinical utility of genomic diagnosis.
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http://dx.doi.org/10.1186/s12864-021-07725-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173916PMC
June 2021

Uncovering residents and restaurants' attitude and willingness toward effective food waste management: A case study of Macau.

Waste Manag 2021 Jul 30;130:107-116. Epub 2021 May 30.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

Food waste has attracted wide attention around the world. A better understanding of food waste generation and consumers' willingness to pay (WTP) for effective food waste management is important for addressing growing food waste challenges, but this is still largely missing in the literature, especially for developing countries and cities in Asia. In this study, we conducted field interviews and questionnaire surveys, with effective samples of 463 residents and 18 restaurants in Macau. Our results show that over 80% of respondents think food waste in Macau is serious. "Food exceeded expiration date (28.2%)" and "Ordering too much food (39.5%)" are the two main reasons for throwing away food at home and when eating out, respectively. Vegetables and fruits (22.4%) are the most common type of food wasted at home, followed by snacks (17.3%), in Macau. About 70% of respondents agreed to pay for separate food waste collection and treatment facilities, and the WTP value per household in Macau is 42.5 MOP (Macau Pataca)/month. Respondents' income level was positively and significantly correlated with their WTP, while age and educational level had negative effects on the WTP, under the 5% significance level. Some respondents' perceptions and attitudes on food waste also significantly affected their WTP, according to our analysis. Because of the lack of effective management measures and collection facilities, about 72% of surveyed restaurants mixed their food waste into municipal solid waste (MSW). More information sharing, education and promotion should be done to raise environmental protection awareness and improve the food waste treatment system.
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http://dx.doi.org/10.1016/j.wasman.2021.05.021DOI Listing
July 2021

Rapid identification and metagenomics analysis of the adenovirus type 55 outbreak in Hubei using real-time and high-throughput sequencing platforms.

Infect Genet Evol 2021 May 21;93:104939. Epub 2021 May 21.

Chinese PLA Center for Disease Control and Prevention, Beijing, China. Electronic address:

The rise in human adenovirus (HAdV) infections poses a serious challenge to public health in China. Real-time (RT) sequencing provides solutions for achieving rapid pathogen identification during outbreaks, whereas high-throughput sequencing yields higher sequence accuracy. In the present study, we report the outcomes of applying nanopore and BGI platforms in the identification and genomic analysis of an HAdV outbreak in Hubei province, China in May of 2019. A mixed sample of nine nasopharyngeal swabs and one single sample were submitted to direct nanopore sequencing (MinION device), generating their first HAdV-55 reads within 13 and 20 min, respectively. The sequences were confirmed by RT-polymerase chain reaction (PCR). Ten HAdV-positive samples were further sequenced using next-generation high-throughput sequencing (BGISEQ-500 device). Phylogenetic analysis revealed that the outbreak strain had a close genetic relation to strains isolated in Sichuan province. Metagenomic analysis showed that HAdV-55 was not a dominant species in samples from which the whole HAdV-55 genome could not be assembled. The present results highlight the value of combining sequencing platforms and using mixed samples for nucleic acid enrichment in pathogen detection of infectious disease outbreaks.
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http://dx.doi.org/10.1016/j.meegid.2021.104939DOI Listing
May 2021

Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate.

Pharmaceutics 2021 Apr 14;13(4). Epub 2021 Apr 14.

Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Metronidazole (MTZ) is an antibacterial drug widely used for the treatment of protozoan and anaerobic infections in humans and animals. However, its low bioavailability necessitates the frequent administration of a high dose to attain an effective plasma concentration profile for therapy. To reduce the dose of MTZ, we have prepared a new cocrystal between MTZ and ethyl gallate (EG). The solid-state properties of MTZ-EG were characterized using complimentary techniques, including thermal, spectroscopic, microscopic, and X-ray crystallographic methods. The MTZ-EG cocrystal exhibits a higher solubility and faster dissolution than MTZ. The bioavailability of MTZ in rats was increased by 36% when MTZ-EG was used.
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http://dx.doi.org/10.3390/pharmaceutics13040546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070254PMC
April 2021

Is there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis.

PLoS One 2021 25;16(3):e0248812. Epub 2021 Mar 25.

Department of Pediatrics in West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Coronary artery lesion (CAL) caused by Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAL. Although most of the current studies have shown a certain correlation between CAL and IVIG resistance, the conclusions are not completely consistent. Thus, we performed this meta-analysis to evaluate the association between IVIG resistance and CAL in KD.

Methods: PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through April 21, 2020 were searched to detect relevant studies. Data analysis was performed with STATA 15.1.

Results: A total of 53 relevant studies were eligible to this analysis, including 30312 KD patients, of which 4750 were IVIG resistance and 25562 were responders. There was a significant difference found between IVIG resistance and IVIG response groups in the incidence of CAL (P < 0.001, odds ratio (OR), 3.89; 95% confidence interval (CI) (3.18, 4.75)). The heterogeneity test results showed that the I2 value was 74.8%. The meta-regression analysis showed that the study regions might be the sources of heterogeneity. The subgroup analysis suggested that the incidence of CAL in the IVIG resistance group was still higher than that in the IVIG response group under different regions, IVIG resistance diagnostic criteria, CAL diagnostic criteria, and study types. Meanwhile, the sensitivity analysis did not find any significant impact from every single study.

Conclusions: This is the first meta-analysis to reveal the incidence of CAL was associated with IVIG resistance in KD patients. Further well-designed studies with uniform criteria are needed to evaluate the incidence of CAL in IVIG resistant patients.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993784PMC
March 2021

Emerging anthropogenic circularity science: principles, practices, and challenges.

iScience 2021 Mar 25;24(3):102237. Epub 2021 Feb 25.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 10084, China.

Material depletion over reliance of linear economies and environmental pollution may be resolved by applying the principles and practices of anthropogenic circularity science. Here we systematically review the emergence of anthropogenic circularity science in the interdisciplinary development of green chemistry, supply chain, and industrial ecology at different scales. The first, second, and third laws of circularity chemistry are proposed as forming the basic principles of circularity science. To close the loop on critical materials, these three basic principles have been exemplified in the anthropogenic circularity practices. We highlight the spatial distribution of critical metal, waste generation, and recycling rate. Future opportunities and challenges for a circular economy and urban mining will predominate in anthropogenic circularity. Therefore, anthropogenic circularity science will play an increasing role in enabling a smooth transition to a circular society.
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http://dx.doi.org/10.1016/j.isci.2021.102237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966983PMC
March 2021

Characterization of Plasmid Co-Harboring NDM-1 and SHV-12 from a Multidrug-Resistant Strain ZT01-0079 in China.

Infect Drug Resist 2021 9;14:947-952. Epub 2021 Mar 9.

School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, People's Republic of China.

Background: The emergence of multidrug-resistant poses daunting challenges to the treatment of clinical infections. The purpose of this study was to characterize the genome of a strain with an IncX3 plasmid encoding both the and genes.

Methods: Strain ZT01-0079 was isolated from a clinical urine sample. The Vitek2 system was used for identification and antimicrobial susceptibility testing. The presence of was detected by PCR and sequencing. Conjugation experiments and Southern blotting were performed to determine the transferability of the - carrying plasmid. Nanopore and Illumina sequencing were performed to better understand the genomic characteristics of the strain.

Results: Strain ZT01-0079 was identified as , and the coexistence of and multiple drug resistance genes was confirmed. Electrophoresis and Southern blotting showed that was located on a ~53kb IncX3 plasmid. The NDM-1-encoding plasmid was successfully transferred at a frequency of 1.68×10. Both the and genes were located on the self-transferable IncX3 plasmid.

Conclusion: The rapid spread of the IncX3 plasmid highlights the importance of continuous monitoring of the prevalence of NDM-1-encoding . Mutations of existing carbapenem resistance genes will bring formidable challenges to clinical treatment.
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http://dx.doi.org/10.2147/IDR.S301736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955740PMC
March 2021

Quantifying material flow of oily sludge in China and its implications.

J Environ Manage 2021 Jun 11;287:112115. Epub 2021 Mar 11.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, 100084, Beijing, China. Electronic address:

Oily sludge is classified as hazardous waste. If not treated properly, it can cause negative impacts on human health and the ecological environment. However, the current lack of macro and micro scientific understanding of the treatment of oily sludge hinders its sound management. In this study, at the microlevel, we selected two of the most common treatment processes of oily sludge and establish a database through data collection and estimation. Material flow analysis was adopted to reveal the generation, pretreatment, recycling, and disposal processes of mechanical separation and incineration. At the macrolevel, this article predicted the material flow of China's whole process management of oily sludge and analyzed the typical flow characteristics of valuable resources in the whole process to guide the formulation of relevant policies in the future. The annual generation of oily sludge in China was between 4.45 and 6.22 Tg, and the average comprehensive utilization rate was approximately 36%. We are still far away from a sound management system despite new legislative revisions. Close supervision and technical processes should be further enhanced shortly.
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http://dx.doi.org/10.1016/j.jenvman.2021.112115DOI Listing
June 2021

Repercussions of COVID-19 pandemic on solid waste generation and management strategies.

Front Environ Sci Eng 2021 5;15(6):115. Epub 2021 Mar 5.

Macao Environmental Research Institute, Macao University of Science and Technology, Macao, 999078 China.

It has been over ten months since the beginning of the 2019 coronavirus disease (COVID-2019), and its impact on solid waste management, especially medical waste, is becoming clearer. This study systematically reviews the potential influences of the COVID-19 pandemic on medical waste, personal protection equipment waste and municipal solid waste (MSW), and discusses the corresponding measures and policies of solid waste management in typical countries. The results show that the generation of medical waste from the pandemic increased significantly, with 18%-425% growth. It is estimated that the daily output of COVID-19 medical waste increased from 200 t/d on Feb. 22 to over 29000 t/d at the end of September 2020 throughout the world. The use of personal protective equipment will continue to grow in the long-term, while the blockade and isolation measures greatly reduced the volume of commercial waste, especially for tourist cities, and part of this waste was transferred to household waste. Residents' attitudes and behavior toward food waste have changed due to the COVID-19 pandemic. In response to the pandemic, international organizations and several countries have issued new policies and guidelines and adjusted their management strategies for medical waste and MSW treatment. The pandemic has brought specific challenges to the disposal capacity of medical waste worldwide. It has also brought about the stagnation of policies related to the reduction of plastic products and waste recycling. This study will provide some useful information for managers and governmental officials on effective solid waste management during and after the COVID-19 pandemic.
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http://dx.doi.org/10.1007/s11783-021-1407-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930516PMC
March 2021

Rapid detection of porcine deltacoronavirus and porcine epidemic diarrhea virus using the duplex recombinase polymerase amplification method.

J Virol Methods 2021 06 15;292:114096. Epub 2021 Feb 15.

College of Veterinary Medicine of South China Agricultural University, Guangzhou, 510640, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, 510640, China; Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, Guangzhou, 510640, China. Electronic address:

Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) have emerged and spread throughout the porcine industry in many countries and are economically important pathogens causing diarrhea in sows and acute death in newborn piglets. Therefore, a sensitive diagnostic method would be beneficial for the prevention and control of PEDV and PDCoV infection. However, traditional detection methods have a number of drawbacks. This research aimed to establish a rapid detection method of duplex recombinant enzyme-mediated thermostatic amplification (RT-RPA) for PEDV and PDCoV. In this study, eight pairs of primers were designed for each virus according to the conserved domains of both PEDV and PDCoV from the NCBI Genbank, and one pair of primers was selected for each virus following the test results. After optimization of the reaction time, reaction temperature and primer concentration ratio, the duplex RT-RPA assay amplified a 226-bp fragment specifically for PEDV and a 321-bp fragment specifically for PDCoV. Meanwhile, the specificity and sensitivity of the primers and clinical samples were tested to verify the establishment of the RT-RPA method. The sensitivities of the duplex RT-RPA method for PEDV and PDCoV were 1 × 10 copies/μL. The results were consistent with PCR results and showed that a detection method for PEDV and PDCoV duplex RT-RPA was successfully established. In summary, the duplex recombinase polymerase amplification method could offer a promising alternative to the duplex RT-qPCR for detection of PEDV and PDCoV.
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http://dx.doi.org/10.1016/j.jviromet.2021.114096DOI Listing
June 2021

Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins.

Rev Neurosci 2021 Aug 15;32(6):615-629. Epub 2021 Feb 15.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu610041, China.

Exercise has been shown to have beneficial effects on brain functions in humans and animals. Exercise can improve memory and learning in age-related neurodegenerative diseases. In animal models, physical exercise regulates epigenetics, promotes synaptic plasticity and hippocampal neurogenesis, regulates the expression levels of neurotrophic factors, and improves cognitive function. Therefore, exercise is very important for brain rehabilitation and remodeling. The purpose of this review is to explore the mechanisms by which exercise exerts positive effects on brain function. This knowledge implies that physical exercise can be used as a non-drug therapy for neurological diseases.
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http://dx.doi.org/10.1515/revneuro-2020-0099DOI Listing
August 2021

Converting spent lithium cobalt oxide battery cathode materials into high-value products via a mechanochemical extraction and thermal reduction route.

J Hazard Mater 2021 Jul 27;413:125222. Epub 2021 Jan 27.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

This study innovatively combines mechanochemistry and high-temperature thermal reduction to achieve the recovery of valuable metals from spent LIBs. First, under the action of mechanical force, the crystal structure of lithium cobalt oxide (LiCoO) found in the cathode materials of spent LIBs was destroyed and converted into lithium carbonate (LiCO) and Li-free residue (C/CoO) using dry ice as a co-grinding reagent. The optimum LiCO recovery conditions were determined to be as follows: a ratio of dry ice: LiCoO powder mass of 20:1; a rotation speed of 700 rpm, and a reaction time of 1.5 h. With these conditions the maximum percentage of LiCO recovered was 95.04 wt%. The CoO in Li-free residue was reduced to a high-value Co product via a high-temperature (800 °C) heat treatment. Gibbs free energy analysis confirmed that the carbon in the Li-free residue could be used as a self-reducing reagent for the thermal reduction of CoO. The reactants and products of each step were characterized by XRD, FT-IR, XPS and SEM techniques. The green route for recycling spent LIBs that this study proposes realizes the green and cost-effective conversion of LiCoO to high-value products, which may become an outstanding example of recycling spent LIBs.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125222DOI Listing
July 2021

Estimation of waste outflows for multiple product types in China from 2010-2050.

Sci Data 2021 01 18;8(1):15. Epub 2021 Jan 18.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, China.

Material flow has been accelerated from underground natural minerals and is accumulating as aboveground waste stock. China is not only the largest producer and consumer of material-driven products, but also the largest generator of product waste. No official annual product waste data are released for China, which creates challenges especially in light of China's emerging waste management policies. Previous studies have presented only estimations of waste streams for single products. In this study, we considered three product types and 33 technological products and collected all the available data. A Kuznets curve and Bass diffusion model were employed to forecast their future consumption. Based on urban consumption metabolism, we created one systematic estimation model of product waste generation related to material flow and social regulation. Typical technological product waste outflows were estimated from 2010 to 2050, which can assist further material flow and environmental impact research, as well as waste management policy-making and technology development. The created model can be potentially extended to other types of product waste estimation.
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http://dx.doi.org/10.1038/s41597-021-00796-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814135PMC
January 2021

Desulfobacterales stimulates nitrate reduction in the mangrove ecosystem of a subtropical gulf.

Sci Total Environ 2021 May 9;769:144562. Epub 2021 Jan 9.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi Research Center for Microbial and Enzyme Engineering Technology, College of Life Science and Technology, Guangxi University, Nanning 530004, China. Electronic address:

The amount of nitrogen compounds discharged into the natural environment has increased drastically due to frequent human activities and led to worsening pollution. The mangrove ecosystem can remove nitrogen pollution, in this regard, few studies had focused on the relationship among nitrogen cycling genes, environmental factors, and taxonomic composition. In this study, shotgun metagenomic sequencing and quantitative polymerase chain reaction were used to understand the nitrogen cycle in the subtropical mangrove ecosystem in the Beibu Gulf of China. Eight nitrogen cycling pathways were annotated. Nitrogen metabolism activities were significantly higher in the wet season than those in the dry season. The most abundant genes were those related to the synthesis and degradation of organic nitrogen, followed by the genes involved in nitrate reduction (denitrification, dissimilation/assimilation nitrate reduction). Furthermore, dissimilation nitrate reduction was the main nitrate reduction pathway. Desulfobacterales plays an important role in nitrogen cycling and contributes 12% of the genes of nitrogen pathways on average; as such, a strong coupling relationship exists among nitrogen cycling, sulfur cycling, and carbon cycling in the mangrove ecosystem. Nitrogen pollution in the mangrove wetland can be efficiently alleviated by nitrate reduction of Desulfobacterales. Nevertheless, only 50% of genes can be matched among the known species, suggesting that many unknown microorganisms in the mangrove ecosystem can perform nitrogen cycling. Total phosphorus, available iron, and total organic carbon are the key environmental factors that influence the distribution of nitrogen cycling genes, related pathways, and the taxonomic composition. Our study clearly illustrates how the mangrove ecosystem mitigates nitrogen pollution through Desulfobacterales. This finding could provide a research reference for the whole nitrogen cycling in the mangrove ecosystem.
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http://dx.doi.org/10.1016/j.scitotenv.2020.144562DOI Listing
May 2021

The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury.

Front Cell Neurosci 2020 15;14:600280. Epub 2020 Dec 15.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that plays an important role in stabilizing nucleosomes and DNA repair. HMGB1 can be passively released from necrotic neurons or actively secreted by microglia, macrophages/monocytes, and neutrophils. Cerebral ischemia is a major cause of mortality and disability worldwide, and its outcome depends on the number of neurons dying due to hypoxia in the ischemic area. HMGB1 contributes to the pathogenesis of cerebral ischemia via mediating neuroinflammatory responses to cerebral ischemic injury. Extracellular HMGB1 regulates many neuroinflammatory events by interacting with its different cell surface receptors, such as receptors for advanced glycation end products, toll-like receptor (TLR)-2, and TLR-4. Additionally, HMGB1 can be redox-modified, thus exerting specific cellular functions in the ischemic brain and has different roles in the acute and late stages of cerebral ischemic injury. However, the role of HMGB1 in cerebral ischemia is complex and remains unclear. Herein, we summarize and review the research on HMGB1 in cerebral ischemia, focusing especially on the role of HMGB1 in hypoxic ischemia in the immature brain and in white matter ischemic injury. We also outline the possible mechanisms of HMGB1 in cerebral ischemia and the main strategies to inhibit HMGB1 pertaining to its potential as a novel critical molecular target in cerebral ischemic injury.
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http://dx.doi.org/10.3389/fncel.2020.600280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770223PMC
December 2020

Apalutamide for metastatic, castration-sensitive prostate cancer in the Japanese population: A subgroup analysis of the randomized, double-blind, placebo-controlled phase 3 TITAN study.

Int J Urol 2021 03 8;28(3):280-287. Epub 2020 Dec 8.

BC Cancer and Vancouver Prostate Centre, Vancouver, British Columbia, Canada.

Objective: To evaluate the efficacy and safety of apalutamide + androgen deprivation therapy versus androgen deprivation therapy alone in Japanese patients with metastatic castration-sensitive prostate cancer from the phase 3, randomized, global TITAN study.

Methods: Men with metastatic castration-sensitive prostate cancer randomly (1:1) received 240 mg apalutamide + androgen deprivation therapy or matching placebo + androgen deprivation therapy. The primary efficacy endpoints were radiographic progression-free survival and overall survival. Secondary efficacy endpoints were time to cytotoxic chemotherapy, pain progression, chronic opioid use, and skeletal-related events. Safety was also assessed.

Results: Of the 1052 patients included in the TITAN study, 51 (4.85%) were Japanese (apalutamide group, n = 28; placebo group, n = 23). In all, 81.8% of patients in the apalutamide and 71.8% in the placebo group did not experience radiographic progression or death, and the hazard ratio for radiographic progression-free survival favored treatment with apalutamide (hazard ratio 0.712, 95% confidence interval 0.205-2.466; P = 0.59). At 24 months, 85.7% of patients in the apalutamide group and 81.5% in the placebo group were alive, and the hazard ratio for overall survival favored apalutamide (hazard ratio 0.840, 95% confidence interval 0.210-3.361; P = 0.805). In the interim analysis, the median radiographic progression-free survival and overall survival were not reached in the apalutamide group and time to cytotoxic chemotherapy was delayed following apalutamide treatment. The safety profile of apalutamide in the Japanese subpopulation was comparable with that of the global population, except for skin rash.

Conclusions: The results of the present analyses suggest that apalutamide + androgen deprivation therapy in Japanese patients had favorable efficacy compared with androgen deprivation therapy alone, and these findings are comparable to those in the overall population. Apalutamide + androgen deprivation therapy can be considered as one of the therapeutic options for a broad spectrum of metastatic castration-sensitive prostate cancer regardless of prior treatment and disease extent in Japanese patients.
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http://dx.doi.org/10.1111/iju.14447DOI Listing
March 2021

Human exposure to PBDEs in e-waste areas: A review.

Environ Pollut 2020 Dec 11;267:115634. Epub 2020 Sep 11.

School of Environment, Tsinghua University, Beijing, 100084, China.

Polybrominated biphenyl ethers (PBDEs) are commonly added to electronic products for flame-retardation effects, and are attracting more and more attentions due to their potential toxicity, durability and bioaccumulation. This study conducts a sysmtematic review to understand the human exposure to PBDEs from e-waste recycling, especially exploring the exposure pathways and human burden of PBDEs as well as investigating the temporal trend of PBDEs exposure worldwide. The results show that the particular foods (contaminated fish, poultry, meat and breast milk) ingestion, indoor dust ingestion and indoor air inhalation may be key factors leading to human health risks of PBDEs exposure in e-waste recycling regions. Residents and some vulnerable groups (occupational workers and children) in e-waste recycling areas may face higher exposure levels and health risks. PBDE exposure is closely related to exposure level, exposure duration, e-waste recycling methods, and dietary customs. High levels of PBDEs are found in human tissues (breast milk, hair, blood (serum), placenta and other tissues) in e-waste areas, at far higher levels than in other areas. Existing data indicate that PBDE exposure levels do not present any apparent downward trend, and will possibly cause serious human diseases. More epidemiological studies are still needed to provide a solid basis for health risk assessment.
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http://dx.doi.org/10.1016/j.envpol.2020.115634DOI Listing
December 2020

Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis.

Mol Nutr Food Res 2021 01 10;65(2):e2000998. Epub 2020 Dec 10.

Human Nutrition Program, The Ohio State University, Columbus, OH, 43210, USA.

Scope: Catechin-rich green tea extract (GTE) limits inflammation in nonalcoholic steatohepatitis (NASH) consistent with a Toll-like receptor 4 (TLR4)-dependent mechanism. It is hypothesized that GTE supplementation during NASH will shift the hepatic metabolome similar to that attributed to the loss-of-TLR4 signaling.

Methods And Results: Wild-type (WT) and loss-of-function TLR4-mutant (TLR4 ) mice are fed a high-fat diet containing 0% or 2% GTE for 8 weeks prior to performing untargeted mass spectrometry-based metabolomics on liver tissue. The loss-of-TLR4 signaling and GTE shift the hepatic metabolome away from that of WT mice. However, relatively few metabolites are altered by GTE in WT mice to the same extent as the loss-of-TLR4 signaling in TLR4 mice. GTE increases acetyl-coenzyme A precursors and spermidine to a greater extent than the loss-of-TLR4 signaling. Select metabolites associated with thiol metabolism are similarly affected by GTE and the loss-of-TLR4 signaling. Glycerophospholipid catabolites are decreased by GTE, but are unaffected in TLR4 mice. Conversely, the loss-of-TLR4 signaling but not GTE increases several bile acid metabolites.

Conclusion: GTE limitedly alters the hepatic metabolome consistent with a TLR4-dependent mechanism. This suggests that the anti-inflammatory activities of GTE and loss-of-TLR4 signaling that regulate hepatic metabolism to abrogate NASH are likely due to distinct mechanisms.
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http://dx.doi.org/10.1002/mnfr.202000998DOI Listing
January 2021

The neural mechanism of aesthetic judgments of dynamic landscapes: an fMRI study.

Sci Rep 2020 11 27;10(1):20774. Epub 2020 Nov 27.

School of Psychology, South China Normal University, Guangzhou, China.

Most previous neuroaesthetics research has been limited to considering the aesthetic judgment of static stimuli, with few studies examining the aesthetic judgment of dynamic stimuli. The present study explored the neural mechanisms underlying aesthetic judgment of dynamic landscapes, and compared the neural mechanisms between the aesthetic judgments of dynamic landscapes and static ones. Participants were scanned while they performed aesthetic judgments on dynamic landscapes and matched static ones. The results revealed regions of occipital lobe, frontal lobe, supplementary motor area, cingulate cortex and insula were commonly activated both in the aesthetic judgments of dynamic and static landscapes. Furthermore, compared to static landscapes, stronger activations of middle temporal gyrus (MT/V5), and hippocampus were found in the aesthetic judgments of dynamic landscapes. This study provided neural evidence that visual processing related regions, emotion-related regions were more active when viewing dynamic landscapes than static ones, which also indicated that dynamic stimuli were more beautiful than static ones.
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http://dx.doi.org/10.1038/s41598-020-77658-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695698PMC
November 2020

Transcatheter closure of a rare congenital left ventricle to right atrium shunt using the amplatzer duct occluder II: A case report.

Medicine (Baltimore) 2020 Nov;99(47):e22576

Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital.

Rationale: Left ventricle-right atrium (LV-RA) shunt is a rare case and surgical repair has been the routine procedure to correct this defect. With the rapid development of transcatheter technology, some of the cases can be closed with transcatheter technique. Here, we would like to report a congenital LV-RA case who received transcatheter closure using the Amplazter duct occluder II (ADO II) and the short-term outcomes of this procedure.

Patient Concerns: A 2-year-old female presented a systolic murmur between the 2 to 3 sternal rib during the routine examination before kindergarten administration.

Diagnosis: The patient denied any cardiac surgery, endocarditis, trauma or cardiomyopathy. The echocardiography confirmed an abnormal shunt between left ventricle and right atrium located in the superior part of ventricular septum which is closed to septal tricuspid valve and anterior mitral valve, and the diameter of this shunt is 2 mm. Besides, the dilation of right atrium (40 mm) has been identified which was not a common clinical manifestation of typical ventricular septal defect. Angiography demonstrated the shunt driven from left ventricle to right atrium.

Intervention: An AGA ADO II device had been delivered to close the defect.

Outcome: Follow-up kept for 3 months. Echocardiography revealed completed closure of the shunt with normal movement and function valves. And no complication of arrhythmia has been recorded.

Lessons: This case report highlighted the administration of ADO II in some ventricular septal defect with superior location, and provided an essential experience of using ADO II to close long tunnel type LV-RA shunt.
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http://dx.doi.org/10.1097/MD.0000000000022576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676515PMC
November 2020

Play Mode Effect of Exergames on Subthreshold Depression Older Adults: A Randomized Pilot Trial.

Front Psychol 2020 26;11:552416. Epub 2020 Oct 26.

Wee Kim Wee School of Communication and Information, College of Humanities, Arts, and Social Sciences, Nanyang Technological University, Singapore, Singapore.

Background: Subthreshold depression is a common mental disorder in late life. Increasing studies have supported the positive effects of exergames to subthreshold depression. The current study aims to investigate how play mode potentially affects exergames' effects on subthreshold depression among older adults.

Method: A between-group experiment was carried out to compare the effect of exergames with different play modes. Fifty-two Singaporean older adults with subthreshold depression were randomly assigned into two conditions, and performed either single-player or multiple-player Nintendo Wii Tennis exergames for 6 weeks, while the key variables of depression, social support and loneliness were measured at both pre- and post-study period.

Results: Findings from path analysis suggested that older adults in multiple-player exergames experienced lower levels of loneliness, and further more reduction on subthreshold depression, when compared to those in single-player exergames. Although social support was not affected by play mode, the significant relationship among social support, loneliness, and depression was found in the context of exergaming.

Conclusion: This study not only provides additional insight into a possible causal association lining play mode and health outcomes of exergames, but also opens the discussion of how to optimize antidepressive effect of exergames for older adults.
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http://dx.doi.org/10.3389/fpsyg.2020.552416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649279PMC
October 2020

Exergaming as a Community Program for Older Adults: The Effects of Social Interaction and Competitive Information.

J Aging Phys Act 2020 10 28;29(3):466-474. Epub 2020 Oct 28.

This study examined how different types of social interaction and competitive information in exergaming affect older adults' motivation and attitude toward playing exergames. A 2 (time: pre- vs. posttest) × 3 (social interaction: play alone vs. play with peer vs. play with youth) × 2 (competition: competition informed vs. noncompetition informed) mixed experiment was conducted with 319 Singaporean older adults over 6 weeks through a three-way analysis of variance. Social interaction was found to significantly affect the changes of extrinsic motivation over time, while competitive information affected intrinsic motivation significantly. The results showed significant three-way interaction effects between time, social interaction, and competitive information on older adults' extrinsic and intrinsic motivations. The changes of attitude over time were not affected by either social interaction or competitive information. The findings contribute to aging research and advance the knowledge of potential factors that promote the effective implementation of exergames for community older adults.
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http://dx.doi.org/10.1123/japa.2020-0188DOI Listing
October 2020

Phylogenetic and Physiological Diversity of Cultivable Actinomycetes Isolated From Alpine Habitats on the Qinghai-Tibetan Plateau.

Front Microbiol 2020 2;11:555351. Epub 2020 Oct 2.

School of Life Sciences, Lanzhou University, Lanzhou, China.

Actinomycetes in extreme alpine habitat have attracted much attention due to their unique physiological activities and functions. However, little is known about their ecological distribution and diversity. Here, we explored the phylogenetic relationship and physiological heterogeneity of cultivable actinomycetes from near-root soils of different plant communities in the Laohu Ditch (2200 - 4200 m) and Gaize County area (5018 - 5130 m) on the Qinghai-Tibetan Plateau. A total of 128 actinomycete isolates were obtained, 16S rDNA-sequenced and examined for antimicrobial activities and organic acid, HS, diffusible pigments, various extracellular enzymes production. Seventy three isolates of the total seventy eight isolates from the Laohu Ditch, frequently isolated from 2200 to 4200 m, were closely related to spp. according to the 16S rDNA sequencing, while four isolates within the genus spp. were found at 2200, 2800, and 3800 m. In addition, one potential novel isolate with 92% sequence similarity to its nearest match from the GenBank database, was obtained at 2200 m. From the Gaize County area, fifty isolates varied in diversity at different sites from 5018 to 5130 m. The investigation of phenotypic properties of 128 isolates showed that 94.5, 78.9, 68, 64.8, 53, 51.6, 50, 36.7, 31.2, and 22.7% of the total isolates produced catalase, lipase 2, urease, protease, HS, lipase 3, amylase, lipase 1, diffusible pigment and organic acid, respectively. The antimicrobial assays of the total isolates revealed that 5, 28, 19, and 2 isolates from spp. exhibited antimicrobial activity against , , , and , respectively. This study intends to bring helpful insights in the exploitation and utilization of alpine actinomycetes for novel bioactive compounds discovery.
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http://dx.doi.org/10.3389/fmicb.2020.555351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566193PMC
October 2020

High-value utilization of graphite electrodes in spent lithium-ion batteries: From 3D waste graphite to 2D graphene oxide.

J Hazard Mater 2021 Jan 20;401:123715. Epub 2020 Aug 20.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

The graphite electrodes of spent lithium-ion batteries (LIBs) have a good crystalline composition and layered structure, and the recovery potential is promising. However, the internal and external surfaces of the waste graphite are often polluted with various organic and inorganic impurities, which seriously restrict its high-value utilization. Herein, the microstructure and surface analysis of waste graphite at variable scales were carried out systematically to reveal the types and occurrence status of impurities and their influence on the preparation of graphene oxide (GO) using a modified Hummers method. The results show that the graphite surface contaminants are polyvinylidene fluoride binder, LiPF electrolyte and LiF residue from the solid electrolyte interface, while residual lithium (LiCO) and CuO were found to have invaded the crystal structure of graphite. Fortunately, the modified Hummers method can effectively remove these complicated associated impurities and prevent their re-contamination on the GO surface. More importantly, the modified Hummers method can not only destroy the longitudinal molecular bonds between graphite layers, but also splice them horizontally to form 2D GO, which is verified by high-resolution transmission electron microscope (HR-TEM) images. This paper provides theoretical support and practical guidance for the high-value utilization of waste graphite in spent LIBs.
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http://dx.doi.org/10.1016/j.jhazmat.2020.123715DOI Listing
January 2021

Retraction Note to: Associations of IL-8 gene polymorphisms and IL-8 levels with predisposition to age-related macular degeneration: a meta-analysis.

Aging Clin Exp Res 2020 Dec;32(12):2705

Department of Ophthalmology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, 311800, Zhejiang, China.

The authors have retracted this article.
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http://dx.doi.org/10.1007/s40520-020-01720-yDOI Listing
December 2020

An analysis of the plastic waste trade and management in Asia.

Waste Manag 2021 Jan 19;119:242-253. Epub 2020 Oct 19.

School of Environment, Tsinghua University, Beijing 100084, China; State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

It is well known that Asia generates and receives large quantities of plastic waste. Through a detailed study of plastic waste generation and trade, the management and treatment of plastic waste in Asia were analyzed from the regional perspective. The amounts of plastic waste in municipal solid waste and in industrial solid waste were estimated to be 79 Mt and 42 Mt, respectively, in Asia. The overall treatment and recycling status in Asia are unsatisfactory. Asia imported 74% of the plastic waste in the world in 2016, and China (mainland) imported the most plastic waste until 2017, with 5.8 to 8.3 Mt. In 2017, about half the plastic waste imported by Asia came from other regions, and after subtracting the exported quantity, 98% of the plastic waste was left in Asia for treatment and disposal. The plastic waste imported by Asia declined about 72% in monetary value in 2018. There is still a large gap between the plastic waste quantity imported to Asia and that exported from Asia. China's ban of plastic waste imports caused import quantities to drop to 52 kt in 2018, simultaneously, exports from the largest exporting countries or regions such as Hong Kong (China), the USA, Japan, and Germany decreased. While Vietnam, Malaysia and some other Asian countries and regions saw significant increases in plastic waste imports from 2016 to 2018. Considering this situation, countries in Asia are starting to strictly limit plastic waste imports from other countries.
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http://dx.doi.org/10.1016/j.wasman.2020.09.049DOI Listing
January 2021
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