Jinhui Ding

Jinhui Ding

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Jinhui Ding

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Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.

Neurobiol Dis 2019 Sep 15;129:67-78. Epub 2019 May 15.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.05.012DOI Listing
September 2019

p.V363I mutation: A rare cause of corticobasal degeneration.

Neurol Genet 2019 Aug 25;5(4):e347. Epub 2019 Jun 25.

Neurodegenerative Disease Research Unit (S.A., M.S.S., S.W.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Movement Disorders and Memory Unit (M.D.F., P.P.), Department of Neurology, University Hospital Mutua de Terrassa, and Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain; Laboratory of Neurogenetics (J.D.), National Institutes on Aging, National Institutes of Health, Bethesda, MD; Neurology Service (L.I.), Hospital Universitari Germans Trias, Pujol, Badalona, Spain; Department of Neurology (A.B., A.P., S.W.S.), Johns Hopkins University Medical Center, Baltimore, MD; Newcastle Institute for Ageing (C.M.M.), Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Neurodegenerative Diseases (C.S., T.G.), Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, Germany; Department of Molecular and Clinical Neuroscience (E.J., H.R.M.), Institute of Neurology, University College London, United Kingdom; Department of Pathology (Neuropathology) (O.P., J.T.), Johns Hopkins University Medical Center, Baltimore, MD; Department of Clinical Neurosciences (H.R.M.), Royal Free Campus UCL, Institute of Neurology, London, United Kingdom; Neurological Tissue Bank (E.G.), University of Barcelona-Hospital Clinic, IDIBAPS, Barcelona, Spain; and Institute of Neurology (E.G.), Medical University of Vienna, Austria.

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http://dx.doi.org/10.1212/NXG.0000000000000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659135PMC
August 2019

Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma.

Ann Diagn Pathol 2019 Jul 4;42:59-63. Epub 2019 Jul 4.

Department of General Surgery, the Center Hospital of Karamay City, Karamay 834000, Xinjiang, China. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2019.06.011DOI Listing
July 2019

Genetic analysis of neurodegenerative diseases in a pathology cohort.

Neurobiol Aging 2019 04 17;76:214.e1-214.e9. Epub 2018 Nov 17.

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391207PMC
April 2019

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice.

Sci Rep 2019 Mar 19;9(1):4857. Epub 2019 Mar 19.

Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41598-019-41091-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425036PMC
March 2019

A novel complete-case analysis to determine statistical significance between treatments in an intention-to-treat population of randomized clinical trials involving missing data.

Authors:
Wei Liu Jinhui Ding

Stat Methods Med Res 2018 04 25;27(4):1067-1075. Epub 2016 May 25.

2 Bioinformatics Core, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/0962280216651307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963886PMC
April 2018

Genetic ablation of dynactin p150 in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.

Mol Neurodegener 2018 03 1;13(1):10. Epub 2018 Mar 1.

Transgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A112, MSC 3707, 35 Convent Drive, Bethesda, MD, 20892-3707, USA.

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http://dx.doi.org/10.1186/s13024-018-0242-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831668PMC
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging.

Sci Rep 2017 12 4;7(1):16890. Epub 2017 Dec 4.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41598-017-17322-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715102PMC
December 2017

Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.

Neurobiol Aging 2017 05 2;53:195.e7-195.e10. Epub 2017 Feb 2.

Research Unit of Clinical Neuroscience, Department of Neurology, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Department of Neurology, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Neurology, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385296PMC
May 2017

ADORA1 mutations are not a common cause of Parkinson's disease and dementia with Lewy bodies.

Mov Disord 2017 02 17;32(2):298-299. Epub 2016 Dec 17.

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mds.26886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318291PMC
February 2017

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.

Neurobiol Dis 2016 Oct 14;94:55-62. Epub 2016 Jun 14.

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983488PMC
October 2016

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.

Hum Mol Genet 2016 08 4;25(16):3515-3523. Epub 2016 Jul 4.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

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http://dx.doi.org/10.1093/hmg/ddw194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179946PMC
August 2016

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.

PLoS One 2015 28;10(8):e0136612. Epub 2015 Aug 28.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, 20892, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552665PMC
May 2016

Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.

PLoS One 2014 10;9(4):e94646. Epub 2014 Apr 10.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983222PMC
June 2015

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease.

Transl Neurodegener 2014 10;3:27. Epub 2014 Dec 10.

Computational Biology Core, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 USA.

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http://dx.doi.org/10.1186/2047-9158-3-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334846PMC
February 2015

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.

EMBO J 2014 Oct 8;33(20):2314-31. Epub 2014 Sep 8.

Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA

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http://dx.doi.org/10.15252/embj.201487807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253522PMC
October 2014

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Proc Natl Acad Sci U S A 2014 Feb 7;111(7):2626-31. Epub 2014 Feb 7.

Cell Biology and Gene Expression Section, Computational Biology Core, Laboratory of Neurogenetics, and Molecular Genetics Section, National Institute on Aging/National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1318306111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932908PMC
February 2014

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.

Hum Mol Genet 2014 Jan 19;23(1):145-56. Epub 2013 Aug 19.

Cell Biology and Gene Expression Section and.

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http://dx.doi.org/10.1093/hmg/ddt407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857951PMC
January 2014

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation.

FASEB J 2014 Jan 30;28(1):382-94. Epub 2013 Sep 30.

2Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. P.G.,

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http://dx.doi.org/10.1096/fj.13-230037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868832PMC
January 2014

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction.

Aging (Albany NY) 2013 Sep;5(9):692-703

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808701PMC
http://dx.doi.org/10.18632/aging.100598DOI Listing
September 2013

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

Hum Mol Genet 2013 Feb 2;22(3):608-20. Epub 2012 Nov 2.

Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/hmg/dds470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542867PMC
February 2013

Validation of a migraine interview for children and adolescents.

Pediatrics 2013 Jan 24;131(1):e96-102. Epub 2012 Dec 24.

Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1542/peds.2012-1008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529946PMC
January 2013

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.

Biochem J 2012 Aug;446(1):99-111

Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1042/BJ20120637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667980PMC
August 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

Mutational analysis of parkin and PINK1 in multiple system atrophy.

Neurobiol Aging 2011 Mar 19;32(3):548.e5-7. Epub 2010 Jan 19.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934211PMC
March 2011

S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4.

J Biol Chem 2010 Jul 26;285(31):23818-28. Epub 2010 May 26.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1074/jbc.M109.091611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911286PMC
July 2010

A simple and efficient algorithm for genome-wide homozygosity analysis in disease.

Mol Syst Biol 2009 15;5:304. Epub 2009 Sep 15.

Laboratory of Neurogenetics, NIA, Porter Neuroscience Building, NIH Main Campus, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/msb.2009.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758715PMC
November 2009

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

PLoS One 2008 Jun 25;3(6):e2484. Epub 2008 Jun 25.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002484PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424241PMC
June 2008

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.

J Biol Chem 2008 Jan 26;283(3):1588-96. Epub 2007 Nov 26.

Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1074/jbc.M708116200DOI Listing
January 2008

Alsin and the molecular pathways of amyotrophic lateral sclerosis.

Mol Neurobiol 2007 Dec 10;36(3):224-31. Epub 2007 Jul 10.

Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892-3707, USA.

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http://dx.doi.org/10.1007/s12035-007-0034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364715PMC
December 2007

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

J Neurochem 2007 Jul 29;102(1):93-102. Epub 2007 Mar 29.

Cell Biology and Gene Expression Unit, National Institute on Aging, Bethesda, Maryland 20982-3707, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04523.xDOI Listing
July 2007

cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome.

BMC Genomics 2007 Jul 27;8:255. Epub 2007 Jul 27.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
Publisher Site
http://dx.doi.org/10.1186/1471-2164-8-255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978503PMC
July 2007