Publications by authors named "Jingzhao Han"

3 Publications

  • Page 1 of 1

Rare primary hepatic carcinosarcoma composed of hepatocellular carcinoma, cholangiocarcinoma, and sarcoma: a case report.

J Int Med Res 2021 Oct;49(10):3000605211050539

Department of Hepatobiliary, Pancreatic, and Splenic Surgery, 117872Hebei General Hospital, Hebei General Hospital, Shijiazhuang, China.

Primary hepatic carcinosarcoma (HCS) is an extremely rare malignant tumor of the liver that contains carcinomatous and sarcomatous components. The diagnosis, treatment, and prognosis of HCS pose great challenges to clinicians. Herein, we present a case of HCS in a 67-year-old man with unique pathological manifestation. Preoperative magnetic resonance imaging showed a malignant lesion in the right liver and a small sub-focus in the left liver. Radical treatment was performed, including excision of the right posterior lobe of the liver, thrombectomy of the right posterior portal vein, and radiofrequency ablation of lesions in the left liver. The specimens were confirmed to be HCS by pathological examinations, which revealed a combination of poorly differentiated hepatocellular carcinoma, moderately differentiated cholangiocellular carcinoma, and spindle cell sarcoma. Transhepatic arterial chemotherapy and embolization was performed after surgery. Unfortunately, pulmonary metastasis occurred 1.5 months later, which meant a poor prognosis. In this report, we discuss the clinicopathological characteristics of this case and factors that affected surgical outcomes, which may add some ideas for the future diagnosis and treatment of HCS patients.
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http://dx.doi.org/10.1177/03000605211050539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516393PMC
October 2021

Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review).

Cancer Biol Ther 2021 04 13;22(4):279-290. Epub 2021 Apr 13.

Department of Hepatobiliary Surgery, General Hospital, Shijiazhuang, Hebei, P. R. China.

The prognosis of hepatocellular carcinoma (HCC), a malignant tumor, is poor. Tumor recurrence and metastasis are the major challenges for the treatment of HCC. Various studies have demonstrated that exosomes, which are loaded with various biomolecules including nucleic acids, lipids, and proteins are involved in the recurrence and metastasis of HCC. Additionally, exosomes mediate various biological processes, such as immune response, cell apoptosis, angiogenesis, thrombosis, autophagy, and intercellular signal transduction. In cancer, exosomes regulate cancer cell differentiation, development, and drug resistance. Circular RNAs, microRNAs, and proteins in the exosomes can serve as early diagnostic and prognostic markers for HCC. As exosomes are characterized by low immunogenicity and high stability in the tissues and circulation, they can be used to deliver the drugs in cancer therapies.
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http://dx.doi.org/10.1080/15384047.2021.1898728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183537PMC
April 2021

Role of chemokines in hepatocellular carcinoma (Review).

Oncol Rep 2021 03 22;45(3):809-823. Epub 2020 Dec 22.

Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China.

Hepatocellular carcinoma (HCC) is a prevalent malignant tumor worldwide, with an unsatisfactory prognosis, although treatments are improving. One of the main challenges for the treatment of HCC is the prevention or management of recurrence and metastasis of HCC. It has been found that chemokines and their receptors serve a pivotal role in HCC progression. In the present review, the literature on the multifactorial roles of exosomes in HCC from PubMed, Cochrane library and Embase were obtained, with a specific focus on the functions and mechanisms of chemokines in HCC. To date, >50 chemokines have been found, which can be divided into four families: CXC, CX3C, CC and XC, according to the different positions of the conserved N‑terminal cysteine residues. Chemokines are involved in the inflammatory response, tumor immune response, proliferation, invasion and metastasis via modulation of various signaling pathways. Thus, chemokines and their receptors directly or indirectly shape the tumor cell microenvironment, and regulate the biological behavior of the tumor. In addition, the potential application of chemokines in chemotaxis of exosomes as drug vehicles is discussed. Exosomes containing chemokines or expressing receptors for chemokines may improve chemotaxis to HCC and may thus be exploited for targeted drug delivery.
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http://dx.doi.org/10.3892/or.2020.7906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859922PMC
March 2021
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