Publications by authors named "Jingyang Wang"

39 Publications

Strategic interaction of original equipment manufacturers between outsourcing and purchasing in a quality-differentiated market.

PLoS One 2022 18;17(1):e0262678. Epub 2022 Jan 18.

School of Logistics, Yunnan University of Finance and Economics, Kunming, China.

Economic globalization has swept the whole world. To focus on their main business, enterprises that are referred to as original equipment manufacturers (OEMs) outsource non-core production activities to contract manufacturers (CMs). By constructing a two-level supply chain consisting of two competing OEMs and one upstream CM, the strategic interaction of the OEMs between outsourcing and purchasing is studied. Specifically, the CM can offer custom- and predefined modes of original equipment manufacturing (namely, CO mode and PO mode, respectively). The former mode enables OEMs to determine product quality, while the latter only allows them to purchase from several quality configurations. The results show that, first, since the CO mode allows the adopter to lead the product design, whether to choose this mode depends on the required R&D cost. Interestingly, however, a lower R&D cost does not necessarily result in the adoption of the CO mode if the product quality difference is small under the PO mode. Second, the optimal purchasing strategy of an OEM is indifferent to the outsourcing mode (CO and PO) of its rival but significantly affected by the quality cost. However, compared to the PO mode, choosing the CO mode would cause the competitor to suffer more profit losses. Third, differing from the prior literature, this paper finds that when the downstream OEM can make quality decisions, although this may lead to profit loss of the contract manufacturer in some channels, it could benefit the CM overall.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765668PMC
January 2022

Suspension electrolyte with modified Li solvation environment for lithium metal batteries.

Nat Mater 2022 Jan 17. Epub 2022 Jan 17.

Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.

Designing a stable solid-electrolyte interphase on a Li anode is imperative to developing reliable Li metal batteries. Herein, we report a suspension electrolyte design that modifies the Li solvation environment in liquid electrolytes and creates inorganic-rich solid-electrolyte interphases on Li. LiO nanoparticles suspended in liquid electrolytes were investigated as a proof of concept. Through theoretical and empirical analyses of LiO suspension electrolytes, the roles played by LiO in the liquid electrolyte and solid-electrolyte interphases of the Li anode are elucidated. Also, the suspension electrolyte design is applied in conventional and state-of-the-art high-performance electrolytes to demonstrate its applicability. Based on electrochemical analyses, improved Coulombic efficiency (up to ~99.7%), reduced Li nucleation overpotential, stabilized Li interphases and prolonged cycle life of anode-free cells (~70 cycles at 80% of initial capacity) were achieved with the suspension electrolytes. We expect this design principle and our findings to be expanded into developing electrolytes and solid-electrolyte interphases for Li metal batteries.
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http://dx.doi.org/10.1038/s41563-021-01172-3DOI Listing
January 2022

The solvation structure, transport properties and reduction behavior of carbonate-based electrolytes of lithium-ion batteries.

Chem Sci 2021 Nov 17;12(44):14740-14751. Epub 2021 Sep 17.

Department of Materials Science and Engineering, University of California Berkeley 210 Hearst Mining Building Berkeley California 94720 USA.

Despite the extensive employment of binary/ternary mixed-carbonate electrolytes (MCEs) for Li-ion batteries, the role of each ingredient with regards to the solvation structure, transport properties, and reduction behavior is not fully understood. Herein, we report the atomistic modeling and transport property measurements of the Gen2 (1.2 M LiPF in ethylene carbonate (EC) and ethyl methyl carbonate (EMC)) and EC-base (1.2 M LiPF in EC) electrolytes, as well as their mixtures with 10 mol% fluoroethylene carbonate (FEC). Due to the mixing of cyclic and linear carbonates, the Gen2 electrolyte is found to have a 60% lower ion dissociation rate and a 44% faster Li self-diffusion rate than the EC-base electrolyte, while the total ionic conductivities are similar. Moreover, we propose for the first time the anion-solvent exchange mechanism in MCEs with identified energetic and electrostatic origins. For electrolytes with additive, up to 25% FEC coordinates with Li, which exhibits a preferential reduction that helps passivate the anode and facilitates an improved solid electrolyte interphase. The work provides a coherent computational framework for evaluating mixed electrolyte systems.
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http://dx.doi.org/10.1039/d1sc04265cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597828PMC
November 2021

Stereoselective Synthesis of -2-Ene-1,4-diones via Aerobic Oxidation of Substituted Furans Catalyzed by ABNO/HNO.

J Org Chem 2021 11 7;86(21):14311-14320. Epub 2021 Oct 7.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

We report a highly efficient and selective catalytic system, ABNO (9-azabicyclo-[3.3.1]nonane -oxyl)/HNO, for the aerobic oxidation of substituted furans to -2-ene-1,4-diones under mild reaction conditions using oxygen as the oxidant. The catalyst system is amenable to various substituted (mon-, di-, and tri-) furans and tolerates diverse functional groups, including cyano, nitro, naphthyl, ketone, ester, heterocycle, and even formyl groups. Based on the control and O-labeling experiments, the possible mechanism of the oxidation is proposed.
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http://dx.doi.org/10.1021/acs.joc.1c00613DOI Listing
November 2021

Synthetic accessibility and stability rules of NASICONs.

Nat Commun 2021 Oct 1;12(1):5752. Epub 2021 Oct 1.

Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

In this paper we develop the stability rules for NASICON-structured materials, as an example of compounds with complex bond topology and composition. By first-principles high-throughput computation of 3881 potential NASICON phases, we have developed guiding stability rules of NASICON and validated the ab initio predictive capability through the synthesis of six attempted materials, five of which were successful. A simple two-dimensional descriptor for predicting NASICON stability was extracted with sure independence screening and machine learned ranking, which classifies NASICON phases in terms of their synthetic accessibility. This machine-learned tolerance factor is based on the Na content, elemental radii and electronegativities, and the Madelung energy and can offer reasonable accuracy for separating stable and unstable NASICONs. This work will not only provide tools to understand the synthetic accessibility of NASICON-type materials, but also demonstrates an efficient paradigm for discovering new materials with complicated composition and atomic structure.
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http://dx.doi.org/10.1038/s41467-021-26006-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486869PMC
October 2021

PhI(OAc)-mediated trifluoromethylthiolation/oxidative cyclization of ynamides.

Org Biomol Chem 2021 Oct 20;19(40):8746-8753. Epub 2021 Oct 20.

College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

A PhI(OAc)-mediated trifluoromethylthiolation/oxidative cyclization of ynamides with the Shen reagent has been established herein, providing a facile access to CFS-substituted oxazolidine-2,4-diones bearing a quaternary carbon center in 38-85% yields with chemoselectivities of up to 99/1.
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http://dx.doi.org/10.1039/d1ob01642cDOI Listing
October 2021

Hydrothermal Synthesis of Zinc-Doped Silica Nanospheres Simultaneously Featuring Stable Fluorescence and Long-Lived Room-Temperature Phosphorescence.

Angew Chem Int Ed Engl 2021 Jul 9;60(28):15490-15496. Epub 2021 Jun 9.

Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Jiangsu, Suzhou, 215123, China.

Fluorescence and phosphorescence are known as two kinds of fundamental optical signals, which have been used for myriad applications. To date, simultaneous activation of stable fluorescence and long-lived room-temperature phosphorescence (RTP) emission in the aqueous phase remains a big challenge. We prepare zinc-doped silica nanospheres ([email protected]) with fluorescence and RTP properties using a facile hydrothermal synthetic strategy. For the as-prepared [email protected], the recombination of electrons and holes in defects and defect-stabilized excitons derived from oxygen vacancy/C=N bonds lead to the production of stable fluorescence and long-lived RTP (emission lasting for ≈9 s, quantum yield (QY): ≈33.6 %, RTP lifetime: ≈236 ms). The internal Si-O bonded networks and hydrophilic surface in [email protected] can reduce nonradiative decay to form self-protective RTP, and also provide high water solubility, excellent pH- and photostability.
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http://dx.doi.org/10.1002/anie.202103200DOI Listing
July 2021

Reduction of structural hierarchy translates into variable influence on the performance of boron nitride aerogel.

iScience 2021 Mar 1;24(3):102251. Epub 2021 Mar 1.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

The rise of ceramic aerogel offers traditional ceramics a new window. Alongside the emerging prospects, what is open to explore includes the elegant design of a ceramic aerogel with tailorable inner organizations, what would occur when complex hierarchy exists in such an already intricate system, and how the properties get influenced as the complexity fades. Borrowing the wisdom from supramolecular world, we exquisitely transform BN aerogel from a complex hierarchy to a flatten microstructure based on solvent-induced morphology switch of its supramolecular precursor gel. Such reduction in structural hierarchy has insignificant effect on the thermal conductivity (∼0.027 W/(m·K)) but shifts the wettability from hydrophobicity to hydrophilicity and occasions nearly 3-fold difference in ion adsorption rate, as exemplified by lead ions. This work may promote the understanding of special hierarchy existing in delicate systems and inspire other attempts to harness the functionality of aerogels by manipulating structural hierarchy.
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http://dx.doi.org/10.1016/j.isci.2021.102251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973872PMC
March 2021

Nickel-Catalyzed Hydrosilylation of Terminal Alkenes with Primary Silanes via Electrophilic Silicon-Hydrogen Bond Activation.

Org Lett 2021 Feb 30;23(4):1434-1439. Epub 2021 Jan 30.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

We report a simple and effective nickel-based catalytic system, NiCl·6HO/BuOK, for the electrophilically activated hydrosilylation of terminal alkenes with primary silanes. This protocol provides excellent performance under mild reaction conditions: exclusive anti-Markovnikov selectivity, broad functional group tolerance (36 examples), and good scalability (TON = 5500). However, the secondary and tertiary silanes are not suitable. Mechanistic studies revealed that this homogeneous catalytic hydrosilylation includes an electrophilically activated Si-H bond process without the generation of nickel hydrides.
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http://dx.doi.org/10.1021/acs.orglett.1c00111DOI Listing
February 2021

[Design of Radial Artery Simulation Platform Based on Waveform Drive].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Feb;45(1):26-31

School of Electrical and Information Engineering, Lanzhou University of Technology, Gansu, Lanzhou, 730050.

In order to obtain the three-dimensional pulse information and blood pressure waveform needed in the study, a radial artery simulation platform with programmable controlled injection pump as the core was constructed by using the circulation theory of human cardiovascular system and pulse wave formation mechanism. Gaussian function model was selected to synthesize multi-type pulse wave to program and drive the platform. The three-dimensional pulse information and blood pressure waveform of the simulated radial artery were collected by binocular visual pulse detection system and pressure transmitter respectively, and the platform stability and repeatability were tested by Pearson correlation. The experimental results show that the radial artery simulation platform is stable, reliable and repeatable, and can generate multiple types of three-dimensional pulse information and blood pressure waveform at the simulated radial artery. The platform is simple in structure, low in cost, and produces many types of pulsating flow. It provides an experimental research platform for revealing the relationship between the three-dimensional pulse information of radial artery and the change of pressure inside the vessel, as well as the prediction of blood pressure waveform from the three-dimensional pulse information.
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http://dx.doi.org/10.3969/j.issn.1671-7104.2021.01.006DOI Listing
February 2021

Promises and Challenges of Next-Generation "Beyond Li-ion" Batteries for Electric Vehicles and Grid Decarbonization.

Chem Rev 2021 Feb 24;121(3):1623-1669. Epub 2020 Dec 24.

Department of Materials Science and Engineering, University of California Berkeley, Berkeley, California 94720, United States.

The tremendous improvement in performance and cost of lithium-ion batteries (LIBs) have made them the technology of choice for electrical energy storage. While established battery chemistries and cell architectures for Li-ion batteries achieve good power and energy density, LIBs are unlikely to meet all the performance, cost, and scaling targets required for energy storage, in particular, in large-scale applications such as electrified transportation and grids. The demand to further reduce cost and/or increase energy density, as well as the growing concern related to natural resource needs for Li-ion have accelerated the investigation of so-called "beyond Li-ion" technologies. In this review, we will discuss the recent achievements, challenges, and opportunities of four important "beyond Li-ion" technologies: Na-ion batteries, K-ion batteries, all-solid-state batteries, and multivalent batteries. The fundamental science behind the challenges, and potential solutions toward the goals of a low-cost and/or high-energy-density future, are discussed in detail for each technology. While it is unlikely that any given new technology will fully replace Li-ion in the near future, "beyond Li-ion" technologies should be thought of as opportunities for energy storage to grow into mid/large-scale applications.
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http://dx.doi.org/10.1021/acs.chemrev.0c00767DOI Listing
February 2021

Incorporating the Nanoscale Encapsulation Concept from Liquid Electrolytes into Solid-State Lithium-Sulfur Batteries.

Nano Lett 2020 Jul 15;20(7):5496-5503. Epub 2020 Jun 15.

Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States.

Solid-state Li-S batteries are attractive due to their high energy density and safety. However, it is unclear whether the concepts from liquid electrolytes are applicable in the solid state to improve battery performance. Here, we demonstrate that the nanoscale encapsulation concept based on [email protected] core-shell particles, originally developed in liquid electrolytes, is effective in solid polymer electrolytes. Using in situ optical cell and sulfur K-edge X-ray absorption, we find that polysulfides form and are well-trapped inside individual particles by the nanoscale TiS encapsulation. This TiS encapsulation layer also functions to catalyze the oxidation reaction of LiS to sulfur, even in solid-state electrolytes, proven by both experiments and density functional theory calculations. A high cell-level specific energy of 427 W·h·kg is achieved by integrating the [email protected] cathode with a poly(ethylene oxide)-based electrolyte and a lithium metal anode. This study points to the fruitful direction of borrowing concepts from liquid electrolytes into solid-state batteries.
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http://dx.doi.org/10.1021/acs.nanolett.0c02033DOI Listing
July 2020

Vibrational hierarchy leads to dual-phonon transport in low thermal conductivity crystals.

Nat Commun 2020 May 22;11(1):2554. Epub 2020 May 22.

School of Mechanical Engineering and the Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA.

Many low-thermal-conductivity (κ) crystals show intriguing temperature (T) dependence of κ: κ ∝ T (crystal-like) at intermediate temperatures whereas weak T-dependence (glass-like) at high temperatures. It has been in debate whether thermal transport can still be described by phonons at the Ioffe-Regel limit. In this work, we propose that most phonons are still well defined for thermal transport, whereas they carry heat via dual channels: normal phonons described by the Boltzmann transport equation theory, and diffuson-like phonons described by the diffusion theory. Three physics-based criteria are incorporated into first-principles calculations to judge mode-by-mode between the two phonon channels. Case studies on LaZrO and TlVSe show that normal phonons dominate low temperatures while diffuson-like phonons dominate high temperatures. Our present dual-phonon theory enlightens the physics of hierarchical phonon transport as approaching the Ioffe-Regel limit and provides a numerical method that should be practically applicable to many materials with vibrational hierarchy.
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http://dx.doi.org/10.1038/s41467-020-16371-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244571PMC
May 2020

The interplay between thermodynamics and kinetics in the solid-state synthesis of layered oxides.

Nat Mater 2020 Oct 18;19(10):1088-1095. Epub 2020 May 18.

Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

In the synthesis of inorganic materials, reactions often yield non-equilibrium kinetic byproducts instead of the thermodynamic equilibrium phase. Understanding the competition between thermodynamics and kinetics is a fundamental step towards the rational synthesis of target materials. Here, we use in situ synchrotron X-ray diffraction to investigate the multistage crystallization pathways of the important two-layer (P2) sodium oxides NaMO (M = Co, Mn). We observe a series of fast non-equilibrium phase transformations through metastable three-layer O3, O3' and P3 phases before formation of the equilibrium two-layer P2 polymorph. We present a theoretical framework to rationalize the observed phase progression, demonstrating that even though P2 is the equilibrium phase, compositionally unconstrained reactions between powder precursors favour the formation of non-equilibrium three-layered intermediates. These insights can guide the choice of precursors and parameters employed in the solid-state synthesis of ceramic materials, and constitutes a step forward in unravelling the complex interplay between thermodynamics and kinetics during materials synthesis.
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http://dx.doi.org/10.1038/s41563-020-0688-6DOI Listing
October 2020

Experimental Study of Shenfu Injection on the Prevention and Treatment of Paclitaxel Chemotherapy DRG Neuron Injury.

Evid Based Complement Alternat Med 2020 17;2020:8239650. Epub 2020 Feb 17.

Department of Medical Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China.

Purpose: The purpose of this paper is investigating the effect and mechanism of Shenfu injection (a Traditional Chinese Medicine injection form) on prevention and treatment of paclitaxel chemotherapy in peripheral nerve injury.

Methods: Wistar rat dorsal root ganglion cells were cultured in vitro and divided into groups of MOCK, PT, PT + LD, and PT + HD. Each group was cultured at a total serum concentration of 10%, including 10% blank serum in the MOCK group, 0.73 (IC30) mol/L paclitaxel + 10% blank serum in the PT group, and 10% and 5% drug-containing serum and equal amount of paclitaxel were added into the high- and low-dosage groups, respectively. After culturing for 24 hours, the following tests were performed: (1) cell proliferation detected by using CCK-8 and a microplate reader; (2) axon length detected by cellular immunostaining and detection analysis on antibody -tubulin III; and (3) changes in mitochondrial membrane potential by analyzing immunofluorescence staining with JC-1 probe.

Results: (1) Cell proliferation: OD values of the MOCK group and PT group were 0.43 ± 0.02 and 0.25 ± 0.03, respectively ( < 0.05), while OD values of groups PT + LD and PT + HD were 0.41 ± 0.05 and 0.46 ± 0.03, respectively, higher than group PT ( < 0.05), while OD values of groups PT + LD and PT + HD were 0.41 ± 0.05 and 0.46 ± 0.03, respectively, higher than group PT (mol/L paclitaxel + 10% blank serum in the PT group, and 10% and 5% drug-containing serum and equal amount of paclitaxel were added into the high- and low-dosage groups, respectively. After culturing for 24 hours, the following tests were performed: (1) cell proliferation detected by using CCK-8 and a microplate reader; (2) axon length detected by cellular immunostaining and detection analysis on antibody mol/L paclitaxel + 10% blank serum in the PT group, and 10% and 5% drug-containing serum and equal amount of paclitaxel were added into the high- and low-dosage groups, respectively. After culturing for 24 hours, the following tests were performed: (1) cell proliferation detected by using CCK-8 and a microplate reader; (2) axon length detected by cellular immunostaining and detection analysis on antibody < 0.05), while OD values of groups PT + LD and PT + HD were 0.41 ± 0.05 and 0.46 ± 0.03, respectively, higher than group PT ( < 0.05), while OD values of groups PT + LD and PT + HD were 0.41 ± 0.05 and 0.46 ± 0.03, respectively, higher than group PT (.

Conclusion: Shenfu injection can prevent the toxicity of DRG neurons induced by paclitaxel, and its mechanism may be related to the alleviation of mitochondrial dysfunction.
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http://dx.doi.org/10.1155/2020/8239650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093904PMC
February 2020

Dual-emission fluorescent silicon nanoparticle-based nanothermometer for ratiometric detection of intracellular temperature in living cells.

Faraday Discuss 2020 06;222(0):122-134

Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu 215123, China.

In this article, we present a kind of dual-emission fluorescent nanothermometer, which is made of europium (Eu3+)-doped silicon nanoparticles ([email protected]), allowing the detection of intracellular temperature in living cells with high accuracy. In particular, the presented SiNP-based thermometer features dual-emission fluorescence (blue (455 nm) and red (620 nm) emission), negligible toxicity (cell viability of treated cells remains above 90% during 24 h of treatment) and robust photostability in living cells (i.e., preserving >90% of fluorescence intensity after 45 min of continuous UV irradiation). More significantly, the fluorescence intensity of the [email protected] exhibits a linear ratiometric temperature response in a broad range from 25 to 70 °C. Taking advantage of these attractive merits, the [email protected] nanothermometer is able to accurately (∼4.5% change per °C) determine dynamic changes in intracellular temperature in a quantitative and long-term (i.e., 30 min) manner.
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http://dx.doi.org/10.1039/c9fd00088gDOI Listing
June 2020

Chemoproteomic Profiling of O-GlcNAcylation in .

Biochemistry 2020 09 4;59(34):3129-3134. Epub 2019 Nov 4.

Tsinghua-Peking Center for Life Sciences, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing 100084, China.

Genetic studies have revealed essential functions of O-linked -acetylglucosamine (O-GlcNAc) modification in . However, large-scale identification of O-GlcNAcylated proteins and mapping the modification sites in remain relatively unexplored. By using a chemoproteomic strategy, we herein report the identification of 108 high-confidence O-GlcNAcylated proteins and 64 modification sites in . Furthermore, quantitative proteomics upon altering O-GlcNAcylation show that the abundance of a large number of proteins are affected by O-GlcNAc. These proteins are involved in regulating reproduction and lifespan, which may correlate with the previously observed phenotypes in genetic studies. The data set in this study reveals the O-GlcNAc modification landscape in and provides a valuable resource for dissecting the biological function of O-GlcNAcylation.
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http://dx.doi.org/10.1021/acs.biochem.9b00622DOI Listing
September 2020

RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog.

Theranostics 2019 24;9(3):811-828. Epub 2019 Jan 24.

Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China.

Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. Its expression is tightly regulated by the ubiquitin-proteasome system in embryonic stem cells (ESCs). Whether the suppression of Nanog ubiquitination contributes to its over-expression in CSCs has not been explored. In addition, the role of receptor for activated C kinase 1 (RACK1), an adaptor protein implicated in HCC growth, in liver CSC-like traits remains to be determined. : and assays were performed to investigate the role of RACK1 in liver CSC-like phenotype and murine ESC function. How RACK1 regulates Nanog expression was explored by immunoblotting and immunohistochemistry. The interaction of RACK1 with Nanog and the consequent effects on Nanog ubiquitination and stemness were then analyzed. : RACK1 promotes self-renewal and chemoresistance of human liver CSCs and maintains murine ESC function. Consistently, RACK1 enhances the expression of Nanog in human HCC cells and murine ESCs. The protein levels of RACK1 in clinical HCC tissues positively correlate with those of Nanog. Further exploration indicates that RACK1 directly binds to Nanog, which prevents its recruitment of E3 ubiquitin ligase FBXW8 and ubiquitin-dependent degradation. The interaction with Nanog is essential for RACK1 to promote stemness. : Our data provide novel insights into the regulation of Nanog protein levels, as well the key role of RACK1 to enhance self-renewal and chemoresistance of CSCs in human HCC.
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http://dx.doi.org/10.7150/thno.29271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376462PMC
January 2020

Disorder in MAX phases at the atomic scale.

Nat Commun 2019 02 7;10(1):622. Epub 2019 Feb 7.

State Key Laboratory of Nuclear Physics and Technology, Center for Applied Physics and Technology, Peking University, 100871, Beijing, China.

Atomic disordering in materials alters their physical and chemical properties and can subsequently affect their performance. In complex ceramic materials, it is a challenge to understand the nature of structural disordering, due to the difficulty of direct, atomic-scale experimental observations. Here we report the direct imaging of ion irradiation-induced antisite defects in MAX phases using double C-corrected scanning transmission electron microscopy and provide compelling evidence of order-to-disorder phase transformations, overturning the conventional view that irradiation causes phase decomposition to binary fcc-structured MX. With the formation of uniformly distributed cation antisite defects and the rearrangement of X anions, disordered solid solution γ-(MA)X phases are formed at low ion fluences, followed by gradual transitions to solid solution fcc-structured (MA)X phases. This study provides a comprehensive understanding of the order-to-disorder transformations in MAX phases and proposes a method for the synthesis of new solid solution (MA)X phases by tailoring the disorder.
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http://dx.doi.org/10.1038/s41467-019-08588-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367347PMC
February 2019

Tunable properties of (HoY)SiO as damage self-monitoring environmental/thermal barrier coating candidates.

Sci Rep 2019 Jan 23;9(1):415. Epub 2019 Jan 23.

High-performance Ceramics Division, Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 110016, Shenyang, China.

RESiO with low thermal conductivity, compatible thermal expansion coefficients and excellent high-temperature reliability in harsh environments are excellent candidates as advanced environmental/thermal barrier coating materials for high-efficiency gas turbine engines. A series of rare earth silicates (HoY)SiO are designed and their properties are comprehensively investigated in this paper. Through doping Ho into YSiO, the thermal conductivity of YSiO is significantly decreased and the thermal expansion coefficient is also optimized closer to Si-based ceramics. High-temperature elastic stiffness and bending strength are increased with the enhancing of Ho content. Most important, doping Ho element provides (HoY)SiO with tunable luminescence characteristic. (HoY)SiO exhibit green, to yellow-green, then to orange-red luminescence color with increased Ho concentration. The results show that they can be used as damage self-monitoring environmental/thermal barrier coating materials for Si-based ceramics.
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http://dx.doi.org/10.1038/s41598-018-36883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344510PMC
January 2019

[Interference Detection and Quality Assessment of Pulse Signal on Android Platform].

Zhongguo Yi Liao Qi Xie Za Zhi 2018 Sep;42(5):321-325

Key Laboratory of Gansu Advanced Control for Industrial Processes, Lanzhou, 730050.

The collection process of the pulse signal is easily disturbed by the noise, that will reduce the quality of the signal, and affect its applications on the healthy monitoring system. In order to solve this problem, this paper analyzes the causes of the generation of interference during pulse signal acquisition and the characteristics of interference performance, and puts forward the corresponding detection algorithm for pulse signal interference section. Based on this algorithm, a Cascaded Layer-by-Layer Discrimination method is proposed to evaluate the quality of pulse signals, in which pulse signals are divided into available signals and unavailable signals. Experimental results on PC and Android platform show that the proposed algorithm can detect the interference segment accurately in the pulse signal in real time, and improve the usability of the evaluation for pulse signal.
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http://dx.doi.org/10.3969/j.issn.1671-7104.2018.05.003DOI Listing
September 2018

Enhanced Photoelectrochemical Properties of Ti Self-Doped Branched TiO₂ Nanorod Arrays with Visible Light Absorption.

Materials (Basel) 2018 Sep 20;11(10). Epub 2018 Sep 20.

Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, School of Physics and Electronic Engineering, Hubei University of Arts and Science, Xiangyang 441053, China.

A novel Ti self-doped branched rutile TiO₂ nanorod arrays (NRAs) was successfully grown on an F-doped tin oxide (FTO) transparent conductive glass by a combined hydrothermal and magnetron sputtering method. Surface morphology, structure, optical properties, and photoelectrochemical behavior of the branched TiO₂ NRAs are determined. Using TiO₂ nanoparticles (NPs) deposited on the top of the nanorods as seeds, TiO₂ nanobranches can easily grow on the top of the nanorods. Moreover, the Ti defects in the TiO₂ NPs and associated oxygen vacancies, and the nanobranches expend the optical absorption edge of the TiO₂ NRAs from 400 nm to 510 nm. Branched TiO₂ NRAs exhibit excellent photoelectrochemical properties compared to the pure TiO₂ NRAs, as revealed by photoelectrochemical measurements. This enhanced photoelectrochemical properties is induced by the increased surface area and expanded optical absorption range. Due to their favorable characteristics, these novel branched TiO₂ NRAs will provide a new path to the fabrication of hierarchical nanostructured materials.
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http://dx.doi.org/10.3390/ma11101791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213866PMC
September 2018

Gingivitis Models - Relevant Approaches to Assess Oral Hygiene Products.

J Clin Dent 2018 Jun;29(2):45-51

Department of Stomatology, Guang'anmen Hospital, China Academy of Chinese Medical Science, Beijing, China.

Objectives: To review the application of gingivitis prevention and treatment models to assess the efficacy of mechanical and chemotherapeutic oral hygiene interventions following shorter- and longer-term use.

Methods: Representative published clinical trials evaluating the shorter- and longer-term anti-gingivitis efficacy of stannous fluoride dentifrice, cetylpyridinium chloride (CPC) rinse, and oscillating-rotating (O-R) electric rechargeable toothbrushes were reviewed. Key gingivitis indices, including the Löe-Silness Gingival Index (LS), Lobene Modified Gingival Index (MGI), Gingival Bleeding Index (GBI), Papillary Bleeding Index (PIBI), and the Mazza modification of the PIBI (Mazza GI), were evaluated for their relative validity and sensitivity in evaluating prevention and treatment outcomes.

Results: Twenty clinical trials were evaluated, including 11 treatment studies and 9 prevention trials. Collectively, the findings demonstrated the efficacy of stabilized stannous fluoride toothpaste, CPC rinses, and O-R electric toothbrushes in improving gingival health both in longer-term prevention and shorter-term treatment models. The studies employed various frequently used gingivitis indices. The indices were sufficiently sensitive to elucidate treatment differences.

Conclusions: Based on the results of this review, gingivitis prevention and treatment studies are valid approaches to show treatment effects, and their utilization is dependent upon whether the intention is to evaluate "reducing the onset of gingivitis" or "reducing the severity of existing gingivitis." Various indices, including the LS, MGI, GBI, PIBI, and Mazza GI indices, provide valid measurements for evaluating gingivitis in treatment and prevention models. Shorter-term treatment models allow for efficient efficacy evaluation in clinically relevant populations with existing disease.
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June 2018

Detection of multipoint pulse waves and dynamic 3D pulse shape of the radial artery based on binocular vision theory.

Comput Methods Programs Biomed 2018 Mar 29;155:61-73. Epub 2017 Nov 29.

College of Computer and Communication, Lanzhou University of Technology, Lanzhou, China.

Background And Objective: Pulse signals contain a wealth of human physiological and pathological information. How to get full pulse information is especially challenging, and most of the traditional pulse sensors can only get the pulse wave of a single point. This study is aimed at developing a binocular pulse detection system and method to obtain multipoint pulse waves and dynamic three-dimensional pulse shape of the radial artery.

Methods: The proposed pulse detection approach is image-based and implemented by two steps. First, a new binocular pulse detection system is developed based on the principle of pulse feeling used in traditional Chinese medicine. Second, pulse detection is achieved based on theories and methods of binocular vision and digital image processing. In detail, the sequences of pulse images collected by the designed system as experimental data are sequentially processed by median filtering, block binarization and inversion, area filtering, centroids extraction of connected regions, to extract the pattern centroids as feature points. Then stereo matching is realized by a proposed algorithm based on Gong-shape scan detection. After multipoint spatial coordinate calculation, dynamic three-dimensional reconstruction of the thin film shape is completed by linear interpolation. And then the three-dimensional pulse shape is achieved by finding an appropriate reference time. Meanwhile, extraction of multipoint pulse waves of the radial artery is accomplished by using a suitable reference origin. The proposed method is analyzed from three aspects, which are pulse amplitude, pulse rate and pulse shape, and compared with other detection methods.

Results: Analysis of the results shows that the values of pulse amplitude and pulse rate are consistent with the characteristics of pulse wave of the radial artery, and pulse shape can correctly present the shape of pulse in space and its change trend in time. The comparison results with the other two previously proposed methods further verify the correctness of the presented method.

Conclusions: The designed binocular pulse detection system and proposed algorithm can effectively detect pulse information. This tactile visualization-based pulse detection method has important scientific significance and broad application prospects and will promote further development of objective pulse diagnosis.
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http://dx.doi.org/10.1016/j.cmpb.2017.11.025DOI Listing
March 2018

Effect of butylphthalide intervention on experimental autoimmune myositis in guinea pigs.

Exp Ther Med 2018 Jan 1;15(1):152-158. Epub 2017 Nov 1.

Department of Neurology, Chinese PLA Medical School, Beijing 100853, P.R. China.

Idiopathic inflammatory myopathies are a group of rare muscular diseases that are characterized by acute, subacute or chronic proximal and symmetric muscle weakness, muscle fiber necrosis and infiltration of inflammatory cells, particularly activated CD8 cytotoxic T cells and phagocytes. 3-n-butylphthalide (NBP) protects mitochondria and reduces the inflammatory response in multiple disease models. In myositis, it has remained elusive whether NBP can protect muscle cells from muscle fiber injury. Experimental autoimmune myositis (EAM) was induced in a total of 40 guinea pigs by myosin immunization. After 4 weeks, low- or high-dose NBP solution was intraperitoneally injected. Saline solution was used as a negative control. After 10 days, the clinical manifestations were assessed by determining rodent grasping power, histopathological changes, Ca-adenosinetriphosphatase (ATPase) activity by an ATPase kit, and mRNA expression of interferon (IFN)-γ, retinoic acid receptor-related orphan nuclear receptor (ROR)γt and forkhead box (Fox) p3 in muscle tissue by reverse-transcription quantitative polymerase chain reaction analysis. It was demonstrated that NBP improved the myodynamia of guinea pigs with EAM and reduced the pathological inflammatory cell infiltration in a dose-dependent manner. NBP improved the Ca-ATPase activity of the muscle mitochondrial membrane and muscle plasma membrane in animals with EAM. It also reduced the mRNA expression of IFN-γ and RORγt, and significantly increased the mRNA expression of Foxp3 in muscle tissue. These results provided a basis for the consideration of NBP as a novel agent for the treatment of myositis and other muscular diseases associated with autoimmunity and inflammation.
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http://dx.doi.org/10.3892/etm.2017.5416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768128PMC
January 2018

3--Butylphthalide reduces the oxidative damage of muscles in an experimental autoimmune myositis animal model.

Exp Ther Med 2017 Sep 11;14(3):2085-2093. Epub 2017 Jul 11.

Department of Neurology, Chinese PLA Medical School, Beijing 100853, P.R. China.

3--Butylphthalide (NBP) protects the mitochondria and reduces apoptosis in multiple disease models. However, it remains to be determined whether NBP can protect muscle cells from oxidative stress, lipid peroxidation and apoptosis in myositis. In the present study, a myosin immunization protocol was applied to induce experimental autoimmune myositis (EAM) in guinea pigs. After 4 weeks, a low- or high-dose NBP solution was injected intraperitoneally into the guinea pigs, with saline solution serving as the negative control. After 10 days, the guinea pigs were sacrificed and muscle cells were isolated for analysis. The results revealed that NBP increased the superoxide dismutase and catalase activity, and reduced malondialdehyde activity in the EAM model. Furthermore, NBP enhanced ATPase activity in muscle mitochondrial membranes and muscle fiber membranes, reduced the number of apoptotic cells, and differentially regulated the Bcl-2, Bax and BAD mRNA and protein expression levels in muscle tissues and sera. NBP directly protects muscle mitochondria and muscle cells from oxidative damage. Notably, NBP reduced muscle cell apoptosis. Thus, it is speculated that, as an antioxidant treatment, NBP may benefit individuals with myopathy.
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http://dx.doi.org/10.3892/etm.2017.4766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609169PMC
September 2017

Design and Imaging of Ground-Based Multiple-Input Multiple-Output Synthetic Aperture Radar (MIMO SAR) with Non-Collinear Arrays.

Sensors (Basel) 2017 Mar 15;17(3). Epub 2017 Mar 15.

School of Information and Electronics, Beijing Institute of Technology, Beijing 100081, China.

Multiple-Input Multiple-Output (MIMO) radar provides much more flexibility than the traditional radar thanks to its ability to realize far more observation channels than the actual number of transmit and receive (T/R) elements. In designing the MIMO imaging radar arrays, the commonly used virtual array theory generally assumes that all elements are on the same line. However, due to the physical size of the antennas and coupling effect between T/R elements, a certain height difference between T/R arrays is essential, which will result in the defocusing of edge points of the scene. On the other hand, the virtual array theory implies far-field approximation. Therefore, with a MIMO array designed by this theory, there will exist inevitable high grating lobes in the imaging results of near-field edge points of the scene. To tackle these problems, this paper derives the relationship between target's point spread function (PSF) and pattern of T/R arrays, by which the design criterion is presented for near-field imaging MIMO arrays. Firstly, the proper height between T/R arrays is designed to focus the near-field edge points well. Secondly, the far-field array is modified to suppress the grating lobes in the near-field area. Finally, the validity of the proposed methods is verified by two simulations and an experiment.
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http://dx.doi.org/10.3390/s17030598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375884PMC
March 2017

Giant Phonon Anharmonicity and Anomalous Pressure Dependence of Lattice Thermal Conductivity in Y2Si2O7 silicate.

Sci Rep 2016 07 19;6:29801. Epub 2016 Jul 19.

High-performance Ceramics Division, Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 110016 Shenyang, China.

Modification of lattice thermal conductivity (κL) of a solid by means of hydrostatic pressure (P) has been a crucially interesting approach that targets a broad range of advanced materials from thermoelectrics and thermal insulators to minerals in mantle. Although it is well documented knowledge that thermal conductivity of bulk materials normally increase upon hydrostatic pressure, such positive relationship is seriously challenged when it comes to ceramics with complex crystal structure and heterogeneous chemical bonds. In this paper, we predict an abnormally negative trend dκL/dP < 0 in Y2Si2O7 silicate using density functional theoretical calculations. The mechanism is disclosed as combined effects of slightly decreased group velocity and significantly augmented scattering of heat-carrying acoustic phonons in pressured lattice, which is originated from pressure-induced downward shift of low-lying optic and acoustic phonons. The structural origin of low-lying optic phonons as well as the induced phonon anharmonicity is also qualitatively elucidated with respect to intrinsic bonding heterogeneity of Y2Si2O7. The present results are expected to bring deeper insights for phonon engineering and modulation of thermal conductivity in complex solids with diverging structural flexibility, enormous bonding heterogeneity, and giant phonon anharmonicity.
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http://dx.doi.org/10.1038/srep29801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949468PMC
July 2016

Hierarchical ZnO Superstructures: Nanoflake-Decorated Nanonail Arrays.

J Nanosci Nanotechnol 2016 Jan;16(1):1170-3

By using metallic Zn powders as zinc source, we synthesized unusual hierarchical ZnO superstructures, nanoflake-decorated nanonail arrays, on a large scale via a simple low-temperature thermal evaporation method. The hierarchical superstructures were characterized by using X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, high resolution transmission electron microscopy as well as selected area electron diffraction. Studies found that both the ZnO nanonails and the decorated ZnO nanoflakes are single-crystals, with the preferred growth orientations along the (001) direction. The possible formation mechanism for the interesting hierarchical superstructures has been discussed. It was found that the deposition of indium films on a Si substrate and the heterogeneous nucleation of ZnO nanoflakes on the main ZnO nanonails play key roles in the fabrication of ZnO superstructures. Moreover, these special hierarchical superstructures showed much strong and complicated photoluminescent emissions in the visible region.
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http://dx.doi.org/10.1166/jnn.2016.10888DOI Listing
January 2016
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