Jingbo Pi

Jingbo Pi

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Jingbo Pi

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miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis.

Biochem Biophys Res Commun 2019 Nov 28. Epub 2019 Nov 28.

Department of Nephrology, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.11.096DOI Listing
November 2019

Combined anesthesia shows better curative effect and less perioperative neuroendocrine disorder than general anesthesia in early stage NSCLC patients.

J Int Med Res 2019 Oct 12;47(10):4743-4752. Epub 2019 Sep 12.

Department of Anesthesia, Second People's Hospital of Banan District, Chongqing, China.

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http://dx.doi.org/10.1177/0300060519862102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833388PMC
October 2019

Correction: Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs.

Br J Cancer 2019 Sep;121(6):511-512

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

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http://dx.doi.org/10.1038/s41416-019-0527-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738118PMC
September 2019

Activation of cannabinoid type 2 receptor protects skeletal muscle from ischemia-reperfusion injury partly via Nrf2 signaling.

Life Sci 2019 Aug 22;230:55-67. Epub 2019 May 22.

Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang 110122, China; Remote Forensic Consultation Center, Collaborative Innovation Center of Judicial Civilization, China University of Political Science and Law, Beijing 100192, China; Collaborative Laboratory of Intelligentized Forensic Science (CLIFS), Shenyang 110032, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.05.056DOI Listing
August 2019

Embracing Systems Toxicology at Single-Cell Resolution.

Curr Opin Toxicol 2019 Aug 19;16:49-57. Epub 2019 Apr 19.

Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/j.cotox.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876623PMC
August 2019

Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice.

Sci Total Environ 2019 Jun 2;668:310-317. Epub 2019 Mar 2.

Program of Environmental Toxicology, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.008DOI Listing
June 2019

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology.

Toxicol Appl Pharmacol 2019 03 4;367:33-35. Epub 2019 Feb 4.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.01.014DOI Listing
March 2019

Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic.

Toxicol Appl Pharmacol 2019 03 8;367:62-70. Epub 2019 Feb 8.

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.02.003DOI Listing
March 2019

Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits.

Toxicol Appl Pharmacol 2018 12 1;360:212-235. Epub 2018 Oct 1.

The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing 400044, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183044
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http://dx.doi.org/10.1016/j.taap.2018.09.036DOI Listing
December 2018

Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity.

Toxicol Appl Pharmacol 2018 11 6;358:1-9. Epub 2018 Sep 6.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New area, Shenyang 110122, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183040
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http://dx.doi.org/10.1016/j.taap.2018.09.004DOI Listing
November 2018

NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice.

Food Chem Toxicol 2018 Nov 21;121:495-503. Epub 2018 Sep 21.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2018.09.042DOI Listing
November 2018

miRNA-182-5p, via HIF2α, contributes to arsenic carcinogenesis: evidence from human renal epithelial cells.

Metallomics 2018 11;10(11):1607-1617

School of Public Health, China Medical University, No. 77 Puhe Road, Shenbei New District, Shenyang, Liaoning, P. R. China110122.

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http://dx.doi.org/10.1039/c8mt00251gDOI Listing
November 2018

PD-1 blockade enhances radio-immunotherapy efficacy in murine tumor models.

J Cancer Res Clin Oncol 2018 Oct 3;144(10):1909-1920. Epub 2018 Aug 3.

Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, China.

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http://dx.doi.org/10.1007/s00432-018-2723-4DOI Listing
October 2018

Nrf2 in alcoholic liver disease.

Toxicol Appl Pharmacol 2018 10 27;357:62-69. Epub 2018 Aug 27.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.08.019DOI Listing
October 2018

Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.

Biochem Biophys Res Commun 2018 09 25;503(1):264-270. Epub 2018 Jun 25.

School of Public Health, China Medical University, Shenyang, 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.06.013DOI Listing
September 2018

NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes.

Oxid Med Cell Longev 2017 10;2017:7417694. Epub 2017 Sep 10.

Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, China.

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https://www.hindawi.com/journals/omcl/2017/7417694/
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http://dx.doi.org/10.1155/2017/7417694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610874PMC
July 2018

Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction.

Nephrol Dial Transplant 2018 05;33(5):771-783

Department of Nephrology, The First Hospital of China Medical University, Shenyang, China.

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http://dx.doi.org/10.1093/ndt/gfx299DOI Listing
May 2018

Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.

Toxicol Appl Pharmacol 2018 05 21;346:28-36. Epub 2018 Mar 21.

Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.03.020DOI Listing
May 2018

Comparative Study on Culture of Mouse Bone Marrow Mesenchymal Stem Cells.

Stem Cells Int 2018 11;2018:6704583. Epub 2018 Apr 11.

Department of Hygiene Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, China.

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http://dx.doi.org/10.1155/2018/6704583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924976PMC
April 2018

silenced insulinoma cells acquire aggressiveness and chemoresistance.

Endocr Relat Cancer 2018 03 4;25(3):185-200. Epub 2017 Dec 4.

Program of Environmental ToxicologySchool of Public Health, China Medical University, Shenyang, People's Republic of China

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http://dx.doi.org/10.1530/ERC-17-0458DOI Listing
March 2018

Silencing of long isoforms of nuclear factor erythroid 2 like 1 primes macrophages towards M1 polarization.

Free Radic Biol Med 2018 03 3;117:37-44. Epub 2018 Feb 3.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC, 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.022DOI Listing
March 2018

circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.

Mol Ther Nucleic Acids 2018 Mar 20;10:245-253. Epub 2017 Dec 20.

Department of Nephrology, The First Hospital of China Medical University, Shenyang, China. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768151PMC
March 2018

Effects of Nrf2 deficiency on arsenic metabolism in mice.

Toxicol Appl Pharmacol 2017 12 3;337:111-119. Epub 2017 Nov 3.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.11.001DOI Listing
December 2017

Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs.

Br J Cancer 2017 Nov 14;117(10):1495-1506. Epub 2017 Sep 14.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China.

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http://dx.doi.org/10.1038/bjc.2017.317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680465PMC
November 2017

Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic β cells to arsenite-induced cytotoxicity.

Toxicol Appl Pharmacol 2017 08 24;329:67-74. Epub 2017 May 24.

Program of Environmental Toxicology, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.05.013DOI Listing
August 2017

Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice.

Sci Rep 2017 03 17;7:44424. Epub 2017 Mar 17.

Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, China.

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http://dx.doi.org/10.1038/srep44424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355880PMC
March 2017

The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response.

Food Chem Toxicol 2017 Feb 25;100:161-167. Epub 2016 Dec 25.

Program of Environmental Toxicology, School of Public Health, China Medical University No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2016.12.016DOI Listing
February 2017

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.

Cell Rep 2017 02;18(8):2030-2044

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.064DOI Listing
February 2017

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy.

Free Radic Biol Med 2016 10 12;99:544-556. Epub 2016 Sep 12.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.09.010DOI Listing
October 2016

The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study.

Biochem Biophys Res Commun 2016 09 21;478(1):87-92. Epub 2016 Jul 21.

School of Public Health, China Medical University, Shenyang, Liaoning, PR China; The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.088DOI Listing
September 2016

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.

Mol Cell Biol 2016 06 16;36(11):1655-72. Epub 2016 May 16.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

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http://dx.doi.org/10.1128/MCB.01095-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959318PMC
June 2016

Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β -Cell Damage.

Oxid Med Cell Longev 2015 9;2015:639191. Epub 2015 Apr 9.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, China.

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http://www.hindawi.com/journals/omcl/2015/639191/
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http://dx.doi.org/10.1155/2015/639191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407529PMC
April 2016

Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells.

Toxicol Appl Pharmacol 2016 Feb 18;292:1-7. Epub 2015 Dec 18.

School of Public Health, China Medical University, 77 Puhe Road, Shenyang North New Area, Shenyang, China; The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.12.008DOI Listing
February 2016

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment.

Toxicol Sci 2015 Oct;147(2):302-16

*Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709; School of Public Health, China Medical University, Shenyang, China; and Unilever, Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, UK.

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http://dx.doi.org/10.1093/toxsci/kfv130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707198PMC
October 2015

CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.

Antioxid Redox Signal 2015 Apr 18;22(10):819-31. Epub 2015 Feb 18.

1 The First Affiliated Hospital, China Medical University , Shenyang, China .

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http://dx.doi.org/10.1089/ars.2014.6017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367236PMC
April 2015

Iodoacetic acid activates Nrf2-mediated antioxidant response in vitro and in vivo.

Environ Sci Technol 2014 Nov 4;48(22):13478-88. Epub 2014 Nov 4.

Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University , Yi Xue Yuan Road 138, Shanghai 200032, China.

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http://dx.doi.org/10.1021/es502855xDOI Listing
November 2014

Curcumin protects human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism.

Oxid Med Cell Longev 2013 21;2013:412576. Epub 2013 Apr 21.

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, Liaoning 110001, China.

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http://dx.doi.org/10.1155/2013/412576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654359PMC
August 2014

Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.

Cancer Prev Res (Phila) 2014 Aug 27;7(8):835-44. Epub 2014 May 27.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine;

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0094DOI Listing
August 2014

Nrf2 in host defense: over the rainbow.

Oxid Med Cell Longev 2013 27;2013:975839. Epub 2013 Oct 27.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD D-201, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1155/2013/975839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826322PMC
July 2014

Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice.

Diabetes 2014 Feb 1;63(2):605-18. Epub 2013 Nov 1.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.2337/db13-0909DOI Listing
February 2014

Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes.

Toxicol Appl Pharmacol 2013 Dec 12;273(3):435-41. Epub 2013 Oct 12.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA; The First Affiliated Hospital, China Medical University, Shenyang 110001, China.

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http://dx.doi.org/10.1016/j.taap.2013.10.005DOI Listing
December 2013

Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages.

Toxicol Appl Pharmacol 2013 Nov 29;272(3):697-702. Epub 2013 Jul 29.

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.taap.2013.07.012DOI Listing
November 2013

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Arch Toxicol 2013 Aug 23;87(8):1315-530. Epub 2013 Aug 23.

Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany.

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http://dx.doi.org/10.1007/s00204-013-1078-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753504PMC
August 2013

Drinking water disinfection byproduct iodoacetic acid induces tumorigenic transformation of NIH3T3 cells.

Environ Sci Technol 2013 Jun 21;47(11):5913-20. Epub 2013 May 21.

Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, China.

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http://dx.doi.org/10.1021/es304786bDOI Listing
June 2013

Organic extract contaminants from drinking water activate Nrf2-mediated antioxidant response in a human cell line.

Environ Sci Technol 2013 May 19;47(9):4768-77. Epub 2013 Apr 19.

Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, People's Republic of China.

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http://dx.doi.org/10.1021/es305133kDOI Listing
May 2013

Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome.

Diabetes 2013 Mar 13;62(3):845-54. Epub 2012 Dec 13.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.2337/db12-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581189PMC
March 2013

Metallothionein blocks oxidative DNA damage in vitro.

Arch Toxicol 2013 Feb 23;87(2):311-21. Epub 2012 Aug 23.

Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1007/s00204-012-0927-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554841PMC
February 2013

Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response.

Environ Health Perspect 2013 Feb 5;121(2):237-43. Epub 2012 Dec 5.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://ehp.niehs.nih.gov/wp-content/uploads/121/2/ehp.120573
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http://ehp.niehs.nih.gov/2013/02/1205731/
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http://dx.doi.org/10.1289/ehp.1205731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569692PMC
February 2013

(S)-α-chlorohydrin inhibits protein tyrosine phosphorylation through blocking cyclic AMP - protein kinase A pathway in spermatozoa.

PLoS One 2012 20;7(8):e43004. Epub 2012 Aug 20.

Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043004PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423423PMC
January 2013

Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review.

Environ Health Perspect 2012 12 10;120(12):1658-70. Epub 2012 Aug 10.

Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1104579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548281PMC
December 2012

Uncoupling and reactive oxygen species (ROS)--a double-edged sword for β-cell function? "Moderation in all things".

Best Pract Res Clin Endocrinol Metab 2012 Dec 18;26(6):753-8. Epub 2012 Sep 18.

Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, SBMRI-Lake Nona, 6400 Sanger Road, Orlando, FL 32827, USA.

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http://dx.doi.org/10.1016/j.beem.2012.08.002DOI Listing
December 2012

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage.

Toxicol Appl Pharmacol 2012 Nov 21;264(3):315-23. Epub 2012 Sep 21.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.taap.2012.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478490PMC
November 2012

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

Nucleic Acids Res 2012 Aug 11;40(15):7416-29. Epub 2012 May 11.

Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/nar/gks409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424561PMC
August 2012

Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.

J Proteome Res 2012 Apr 19;11(4):2480-91. Epub 2012 Mar 19.

Division of Pulmonary, Allergy and Critical Care Medicine, Small Molecule Synthesis Facility and Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, United States.

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http://dx.doi.org/10.1021/pr201180mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327136PMC
April 2012

Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program.

Endocrinology 2011 Jun 29;152(6):2247-55. Epub 2011 Mar 29.

Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1210/en.2010-1036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100623PMC
June 2011

Acute stimulation of white adipocyte respiration by PKA-induced lipolysis.

Diabetes 2010 Oct 3;59(10):2474-83. Epub 2010 Aug 3.

Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.2337/db10-0245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279548PMC
October 2010

The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel.

BMC Med Genomics 2010 Aug 13;3:37. Epub 2010 Aug 13.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939609PMC
August 2010

Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.

Environ Health Perspect 2010 Jun 25;118(6):864-70. Epub 2010 Jan 25.

Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 , USA.

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http://dx.doi.org/10.1289/ehp.0901608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898865PMC
June 2010

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.

Toxicol Appl Pharmacol 2010 Apr 6;244(1):77-83. Epub 2009 Jun 6.

Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.taap.2009.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837798PMC
April 2010

A systems biology perspective on Nrf2-mediated antioxidant response.

Toxicol Appl Pharmacol 2010 Apr 28;244(1):84-97. Epub 2009 Aug 28.

Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837757PMC
April 2010

Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.

Toxicology 2009 Aug 12;262(2):162-70. Epub 2009 Jun 12.

Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.tox.2009.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747077PMC
August 2009

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Endocrinology 2009 Jul 26;150(7):3040-8. Epub 2009 Feb 26.

Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1210/en.2008-1642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703519PMC
July 2009

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages.

Toxicol Appl Pharmacol 2009 Jul 17;238(1):27-36. Epub 2009 Apr 17.

Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697450PMC
July 2009

Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses.

Toxicol Appl Pharmacol 2009 Jun 14;237(3):345-56. Epub 2009 Apr 14.

Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696203PMC
June 2009

Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes.

J Biol Chem 2009 May 31;284(21):14087-95. Epub 2009 Mar 31.

Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M807992200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682857PMC
May 2009

Induction of heme oxygenase 1 by arsenite inhibits cytokine-induced monocyte adhesion to human endothelial cells.

Toxicol Appl Pharmacol 2009 Apr 6;236(2):202-9. Epub 2009 Feb 6.

College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA.

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http://dx.doi.org/10.1016/j.taap.2009.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619387PMC
April 2009

Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice.

J Lipid Res 2009 Jan 12;50(1):59-70. Epub 2008 Aug 12.

The Endocrine Biology Program, Division of Translational Biology, The Hamner Institutes for Health Sciences, NC 27709, USA.

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http://dx.doi.org/10.1194/jlr.M800273-JLR200DOI Listing
January 2009

Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burning.

Bull Environ Contam Toxicol 2008 Oct 25;81(4):406-11. Epub 2008 Jun 25.

Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110001, China.

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October 2008

New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction.

Biochem Pharmacol 2008 Oct 23;76(7):922-8. Epub 2008 Jul 23.

Zunyi Medical College, Key Laboratory of Pharmacology, 201 Dalian Road, Zunyi 563000, China.

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http://dx.doi.org/10.1016/j.bcp.2008.07.021DOI Listing
October 2008

Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.

Free Radic Biol Med 2008 Sep 3;45(5):651-8. Epub 2008 Jun 3.

Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658531PMC
September 2008

Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling.

Am J Physiol Lung Cell Mol Physiol 2008 Mar 21;294(3):L469-77. Epub 2007 Dec 21.

Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Dr., Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1152/ajplung.00310.2007DOI Listing
March 2008

Hormesis and adaptive cellular control systems.

Dose Response 2008 Mar 19;6(2):196-208. Epub 2008 Mar 19.

Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.2203/dose-response.07-028.ZhangDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478522PMC
March 2008

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid.

Toxicol Appl Pharmacol 2008 Feb 26;226(3):236-43. Epub 2007 Sep 26.

Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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February 2008

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase.

J Biol Chem 2007 Oct 27;282(41):30143-9. Epub 2007 Aug 27.

Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M702390200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408735PMC
October 2007

Reactive oxygen species as a signal in glucose-stimulated insulin secretion.

Diabetes 2007 Jul 30;56(7):1783-91. Epub 2007 Mar 30.

Endocrine Biology Program, The Hamner Institutes for Health Sciences, 6 Davis Dr., Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.2337/db06-1601DOI Listing
July 2007

Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway.

Environ Health Perspect 2007 Jul;115(7):1094-100

Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NC 27709, USA.

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http://dx.doi.org/10.1289/ehp.10075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913575PMC
July 2007

Metabolic syndrome and urinary cGMP excretion in general population.

Atherosclerosis 2007 Feb 24;190(2):423-8. Epub 2006 Mar 24.

Department of Public Health, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.atherosclerosis.2006.02.032DOI Listing
February 2007

Current research problems of chronic arsenicosis in China.

J Health Popul Nutr 2006 Jun;24(2):176-81

Department of Occupational Health, School of Public Health, China Medical University, Shenyang 110001, China.

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June 2006

Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis.

Int J Cancer 2005 Aug;116(1):20-6

Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1002/ijc.20990DOI Listing
August 2005

Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress.

Int J Cancer 2005 Apr;114(3):346-55

Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1002/ijc.20736DOI Listing
April 2005

Relationship between urinary cGMP excretion and serum total cholesterol levels in a general population.

Atherosclerosis 2005 Apr 7;179(2):379-86. Epub 2005 Jan 7.

Department of Public Health, Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.atherosclerosis.2004.10.031DOI Listing
April 2005

Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine.

Toxicol Appl Pharmacol 2004 Aug;198(3):291-6

Department of Preventive Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.

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http://dx.doi.org/10.1016/j.taap.2003.10.021DOI Listing
August 2004

Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunction.

Toxicol Appl Pharmacol 2004 Aug;198(3):450-7

Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.taap.2003.10.031DOI Listing
August 2004

Urinary cyclic GMP excretion and blood pressure levels in a general population.

Atherosclerosis 2004 Jan;172(1):161-6

Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.atherosclerosis.2003.09.018DOI Listing
January 2004