Dr. Jing Xie, Ph.D. - Johns Hopkins University

Dr. Jing Xie

Ph.D.

Johns Hopkins University

Baltimore, MD | United States

Main Specialties: Biology

Additional Specialties: Stem cell; epigenetic

Dr. Jing Xie, Ph.D. - Johns Hopkins University

Dr. Jing Xie

Ph.D.

Introduction

Primary Affiliation: Johns Hopkins University - Baltimore, MD , United States

Specialties:

Additional Specialties:

Research Interests:

Education

Mar 2012
Department of Biology, The Johns Hopkins University
Postdoc
Nov 2010
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ph.D.

Experience

Sep 2017
Tongji University, China
PI, Lab Head, Professor

Publications

11Publications

283Reads

202Profile Views

84PubMed Central Citations

Enhancer of polycomb maintains germline activity and genome integrity in Drosophila testis.

Cell Death Differ 2018 08 23;25(8):1486-1502. Epub 2018 Jan 23.

Department of Biology, The Johns Hopkins University, Baltimore, MD, 21218, USA.

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http://dx.doi.org/10.1038/s41418-017-0056-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113212PMC
August 2018
11 Reads
8.184 Impact Factor

Breaking Symmetry - Asymmetric Histone Inheritance in Stem Cells.

Trends Cell Biol 2017 07 6;27(7):527-540. Epub 2017 Mar 6.

Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476491PMC
July 2017
21 Reads
12.010 Impact Factor

A novel role for synaptic acetylcholinesterase as an apoptotic deoxyribonuclease.

Cell Discov 2015 28;1:15002. Epub 2015 Apr 28.

The State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai, China.

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http://dx.doi.org/10.1038/celldisc.2015.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851313PMC
July 2016
38 Reads
1 Citation

Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline.

Cell 2015 Nov 29;163(4):920-33. Epub 2015 Oct 29.

Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636931PMC
November 2015
71 Reads
17 Citations
32.242 Impact Factor

Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline

Cell. 2015 Nov 5; 163(4): 920–933.

Cell

A long-standing question concerns how stem cells maintain their identity through multiple divisions. Previously we reported that pre-existing and newly synthesized histone H3 are asymmetrically distributed during Drosophila male germline stem cell (GSC) asymmetric division. Here we show that phosphorylation at Threonine 3 of H3 (H3T3P) distinguishes preexisting versus newly synthesized H3. Converting T3 to the unphosphorylatable residue alanine (H3T3A) or to the phosphomimetic aspartate (H3T3D) disrupts asymmetric H3 inheritance. Expression of H3T3A or H3T3D specifically in early-stage germline also leads to cellular defects including GSC loss and germline tumors. Finally, compromising the activity of the H3T3 kinase Haspin enhances the H3T3A but suppresses the H3T3D phenotypes. Together these studies demonstrate that H3T3P distinguishes sister chromatids enriched with distinct pools of H3, coordinating asymmetric segregation of “old” H3 into GSCs, and that a tight regulation of H3T3 phosphorylation is required for male germline activity.

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October 2015
15 Reads

Asymmetric division of Drosophila male germline stem cell shows asymmetric histone distribution.

Science 2012 Nov;338(6107):679-82

Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1126/science.1226028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532436PMC
November 2012
26 Reads
37 Citations
31.480 Impact Factor

Acetylcholinesterase blocks cleavage of APP by γ-secretase in 293 cells and mouse brain

Mol Neurodegener. 2012; 7(Suppl 1): S11.

Molecular Neurodegeneration

γ-Secretase cleaves amyloid precursor protein (APP) to produce Aβ peptide, and the secretase is a critical factor in the pathogenesis of Alzheimer’s Disease (AD), whereas acetylcholinesterase (AChE) is a key factor for maintaining normal nerve impulses. However, there has been no published research that focuses on the relationship between these two factors. γ-Secretase cleaves various substrates, and loss of function of γ-secretase is lethal. Thus, the mechanism by which γ-secretase cleaves APP is a key factor in AD pathogenesis. AChE is one of the main targets in the treatment of AD, and AChE inhibitors are commonly used for AD. Currently there is agreement that AChE inhibitors stabilizes acetylcholine (ACh) levels in the brain, which ensures ACh transport among neurons. However, the actual effect is limited. It has been reported that AChE interacts with PS1 and affects its glycosylation. This result suggests a link between AChE and γ-secretase. Here, we have tested the effects of AChE on cleavage of APP by γ-secretase.

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February 2012
15 Reads

Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway.

J Mol Cell Biol 2011 Aug 3;3(4):250-9. Epub 2011 Mar 3.

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1093/jmcb/mjq047DOI Listing
August 2011
36 Reads
10 Citations

AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion.

Apoptosis 2010 Apr;15(4):474-87

Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1007/s10495-009-0438-3DOI Listing
April 2010
31 Reads
9 Citations
3.685 Impact Factor

Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest.

Cell Mol Life Sci 2008 Jun;65(11):1768-79

Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1007/s00018-008-8016-3DOI Listing
June 2008
16 Reads
4 Citations
5.810 Impact Factor

Mitochondria and calpains mediate caspase-dependent apoptosis induced by doxycycline in HeLa cells.

Cell Mol Life Sci 2006 Apr;63(7-8):949-57

Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1007/s00018-005-5565-6DOI Listing
April 2006
33 Reads
6 Citations
5.810 Impact Factor

Top co-authors

Xin Chen
Xin Chen

College of Life Sciences

4
Vuong Tran
Vuong Tran

Johns Hopkins University

3
Jun Wu
Jun Wu

State Key Laboratory of Trauma

3
Xuejin Zhang
Xuejin Zhang

College of Foreign Language

2
Xin Niu
Xin Niu

Institute of Microsurgery on Extremities

2
Xuejun Zhang
Xuejun Zhang

Anhui Medical University

2
Matthew Wooten
Matthew Wooten

The Johns Hopkins University

2
Xiaowen Gong
Xiaowen Gong

The College of Veterinary Medicine of the Northwest Agriculture and Forestry University

1
Qi Ouyang
Qi Ouyang

Center for Quantitative Biology

1
Weiyuan Ye
Weiyuan Ye

State Key Laboratory of Cell Biology

1