Publications by authors named "Jing Gu"

329 Publications

Difficulties encountered by public health workers in COVID-19 outbreak: a cross-sectional study based on five provinces.

BMC Health Serv Res 2021 Jul 5;21(1):656. Epub 2021 Jul 5.

School of Public Health, Global Health Institute, Key Laboratory of Tropical Disease Control, Sun Yat-sen University, 510080, Guangzhou, China.

Objectives: The aim of this study is to address the difficulties encountered by public health workers in the early and middle stages of their efforts to combat COVID-19, compare the gaps among different types of institutions, and identify shortcomings in epidemic control.

Methods: Using multi-stage sampling, a survey of public health workers involved in the prevention and control of COVID-19 was conducted from 18 February to 1 March 2020 through a self-administered questionnaire. These public health workers were from the primary health care center (defined as "primary-urban" and "primary-rural" for those in urban and rural areas, respectively) and the center for disease control and prevention (defined as "non-primary") in five provinces including Hubei, Guangdong, Sichuan, Jiangsu and Gansu, China.

Results: A total of 9,475 public health workers were surveyed, of which 40.0 %, 27.0 % and 33.0 % were from the primary-rural, primary-urban and non-primary, respectively. The resources shortage were reported by 27.9 % participants, with the primary-rural being the worst affected (OR = 1.201, 95 %CI: 1.073-1.345). The difficulties in data processing were reported by 31.5 % participants, with no significant differences among institutions. The difficulties in communication and coordination were reported by 29.8 % participants, with the non-primary being the most serious (primary-rural: OR = 0.520, 95 %CI: 0.446-0.606; primary-urban: OR = 0.533, 95 %CI: 0.454-0.625). The difficulties with target audiences were reported by 20.2 % participants, with the primary-urban being the worst (OR = 1.368, 95 %CI: 1.199-1.560). The psychological distress were reported by 48.8 % participants, with no significant differences among institutions.

Conclusions: Psychological distress is the most serious problem in the prevention and control of COVID-19. Resources shortage in primary-rural, difficulties in communication and coordination in non-primary, and difficulties with target audiences in the primary-urban deserve attention. This study will provide scientific evidences for improving the national public health emergency management system, especially for reducing the urban-rural differences in emergency response capacity.
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http://dx.doi.org/10.1186/s12913-021-06699-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256394PMC
July 2021

CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.

Dis Markers 2021 16;2021:8837825. Epub 2021 Jun 16.

Department of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241002, China.

Diabetic nephropathy (DN) is one of the most lethal complications of diabetes mellitus with chronic inflammation. We have examined the role of the inflammatory chemokine CCL24 in DN. We observed that serum levels of CCL24 were significantly elevated in patients with DN. Not only that, the expression of CCL24 was significantly increased in the kidneys of DN mice. The kidney of DN mice showed increased renal fibrosis and inflammation. We characterized an in vitro podocyte cell model with high glucose. Western blot analysis showed that expression of CCL24 was significantly increased under high-glucose conditions. Stimulation with high glucose (35 mmol/L) resulted in an increase in CCL24 expression in the first 48 hours but changed little after 72 hours. Moreover, with glucose stimulation, the level of podocyte fibrosis gradually increased, the expression of the proinflammatory cytokine IL-1 was upregulated, and the expression of the glucose transporter GLUT4, involved in the insulin signal regulation pathway, also increased. It is suggested that CCL24 is involved in the pathogenesis of DN. In order to study the specific role of CCL24 in this process, we used the CRISPR-Cas9 technique to knock out CCL24 expression in podocytes. Compared with the control group, the podocyte inflammatory response induced by high glucose after CCL24 knockout was significantly increased. These results suggest that CCL24 plays a role in the development of early DN by exerting an anti-inflammatory effect, at least, in podocytes.
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http://dx.doi.org/10.1155/2021/8837825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221868PMC
June 2021

[Determination of four antipyretic and analgesic drugs in water by solid-phase extraction coupled ultra-performance liquid chromatography-tandem mass spectrometry].

Se Pu 2020 Dec;38(12):1465-1471

Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

The widespread use of pharmaceutical and personal care products (PPCPs), including antipyretic and analgesic drugs, in the last two decades had led to the existence of PPCP residues in the environment, thus raising concerns about their pseudo-persistent nature and potential threat to human health. Generally, most of the detected contaminants are present at low levels (ranging from ng/L to μg/L) in environmental water. Therefore, advanced analytical methodologies are crucial to monitor the occurrence and distribution of antipyretic and analgesic drugs in environmental water. However, trace analysis of environmental pollutants is always challenging because it is necessary to extract analytes present in the sample at ultralow levels from complex environmental matrices. Therefore, an appropriate sample pretreatment is necessary to enrich the target compounds. Conventional solid-phase extraction materials show poor efficiency for the enrichment of antipyretic and analgesic drugs. We herein report a hydrophilic and lipophilic amphiphilic porous polymeric material GCHM (Guochuang hydrophilic material). GCHM was successfully prepared by a stepwise emulsification and micellization process using -vinyl-2-pyrrolidone (NVP) and divinylbenzene (DVB) as raw materials. An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of four antipyretic and analgesic drugs in water using our solid-phase extraction (SPE) column. The water samples were extracted and purified by the GCHM solid-phase extraction column, and then analyzed by UPLC-MS/MS. Gradient elution was carried out with 0.1% formic acid aqueous solution and acetonitrile as the mobile phase. The target analytes were separated on an ACQUITY UPLC HSS T3 column (100 mm×2.1 mm, 1.8 μm), and multiple reaction monitoring (MRM) was conducted in the positive electrospray ionization mode. The isotope internal standard method was used for quantitative correction. Comparison of the enrichment efficiencies of Oasis HLB, Bond Elut Plexa, and GCHM revealed that GCHM showed the best performance. Different pH values affecting the enrichment efficiency of the GCHM SPE column were optimized, and the matrix effect was evaluated. The results showed that the four target analytes gave the best enrichment effect on the SPE column at pH 7, and the matrix effect for each substance was between 82.8% and 102.2%, indicating obvious matrix removal after the water sample was purified by the GCHM SPE column. Good correlation coefficients () greater than 0.995 were observed for all the target compounds in the range of 1-100 μg/L. The method limits of quantitation (=10) ranged from 1 ng/L to 5 ng/L. The corrected recoveries were 85.6% to 106.4%, and the relative standard deviations (RSD) were under 5.6%. The GCHM solid-phase extraction column is inexpensive and efficient, being suitable for the detection of the four antipyretic and analgesic drugs in water. Subsequently, the occurrence of these selected antipyretic and analgesic drugs in water samples from Shanghai, Jiangsu, and Guangdong provinces were studied. The GCHM column has potential advantages over the commercial imported SPE column and is worthy of widespread application. This column can also aid the enrichment and purification of other compounds with similar structures or properties in water.
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http://dx.doi.org/10.3724/SP.J.1123.2020.07002DOI Listing
December 2020

[Determination of four antipyretic and analgesic drugs in water by solid-phase extraction coupled ultra-performance liquid chromatography-tandem mass spectrometry].

Se Pu 2020 Dec;38(12):1465-1471

Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

The widespread use of pharmaceutical and personal care products (PPCPs), including antipyretic and analgesic drugs, in the last two decades had led to the existence of PPCP residues in the environment, thus raising concerns about their pseudo-persistent nature and potential threat to human health. Generally, most of the detected contaminants are present at low levels (ranging from ng/L to μg/L) in environmental water. Therefore, advanced analytical methodologies are crucial to monitor the occurrence and distribution of antipyretic and analgesic drugs in environmental water. However, trace analysis of environmental pollutants is always challenging because it is necessary to extract analytes present in the sample at ultralow levels from complex environmental matrices. Therefore, an appropriate sample pretreatment is necessary to enrich the target compounds. Conventional solid-phase extraction materials show poor efficiency for the enrichment of antipyretic and analgesic drugs. We herein report a hydrophilic and lipophilic amphiphilic porous polymeric material GCHM (Guochuang hydrophilic material). GCHM was successfully prepared by a stepwise emulsification and micellization process using -vinyl-2-pyrrolidone (NVP) and divinylbenzene (DVB) as raw materials. An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of four antipyretic and analgesic drugs in water using our solid-phase extraction (SPE) column. The water samples were extracted and purified by the GCHM solid-phase extraction column, and then analyzed by UPLC-MS/MS. Gradient elution was carried out with 0.1% formic acid aqueous solution and acetonitrile as the mobile phase. The target analytes were separated on an ACQUITY UPLC HSS T3 column (100 mm×2.1 mm, 1.8 μm), and multiple reaction monitoring (MRM) was conducted in the positive electrospray ionization mode. The isotope internal standard method was used for quantitative correction. Comparison of the enrichment efficiencies of Oasis HLB, Bond Elut Plexa, and GCHM revealed that GCHM showed the best performance. Different pH values affecting the enrichment efficiency of the GCHM SPE column were optimized, and the matrix effect was evaluated. The results showed that the four target analytes gave the best enrichment effect on the SPE column at pH 7, and the matrix effect for each substance was between 82.8% and 102.2%, indicating obvious matrix removal after the water sample was purified by the GCHM SPE column. Good correlation coefficients () greater than 0.995 were observed for all the target compounds in the range of 1-100 μg/L. The method limits of quantitation (=10) ranged from 1 ng/L to 5 ng/L. The corrected recoveries were 85.6% to 106.4%, and the relative standard deviations (RSD) were under 5.6%. The GCHM solid-phase extraction column is inexpensive and efficient, being suitable for the detection of the four antipyretic and analgesic drugs in water. Subsequently, the occurrence of these selected antipyretic and analgesic drugs in water samples from Shanghai, Jiangsu, and Guangdong provinces were studied. The GCHM column has potential advantages over the commercial imported SPE column and is worthy of widespread application. This column can also aid the enrichment and purification of other compounds with similar structures or properties in water.
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http://dx.doi.org/10.3724/SP.J.1123.2020.07002DOI Listing
December 2020

High-Voltage Cathode α-FeO Nanoceramics for Rechargeable Sodium-Ion Batteries.

ACS Omega 2021 May 10;6(19):12615-12622. Epub 2021 May 10.

College of Electronic and Optical Engineering & College of Microelectronics, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Previously, α-FeO nanocrystals are recognized as anode materials owing to their high capacity and multiple properties. Now, this work provides high-voltage α-FeO nanoceramics cathodes fabricated by the solvothermal and calcination processes for sodium-ion batteries (SIBs). Then, their structure and electrical conductivity were investigated by the first-principles calculations. Also, the SIB with the α-FeO nanoceramics cathode exhibits a high initial charge-specific capacity of 692.5 mA h g from 2.0 to 4.5 V at a current density of 25 mA g. After 800 cycles, the discharge capacity is still 201.8 mA h g, well exceeding the one associated with the present-state high-voltage SIB. Furthermore, the effect of the porous structure of the α-FeO nanoceramics on sodium ion transport and cyclability is investigated. This reveals that α-FeO nanoceramics will be a remarkably promising low-cost and pollution-free high-voltage cathode candidate for high-voltage SIBs.
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http://dx.doi.org/10.1021/acsomega.1c00640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154118PMC
May 2021

Novel Solid-State Sodium-Ion Battery with Wide Band Gap NaTi(PO) Nanocrystal Electrolyte.

ACS Omega 2021 May 22;6(17):11537-11544. Epub 2021 Apr 22.

Department of Microelectronics, Delft University of Technology, Delft 2628 CD, the Netherlands.

NaTi(PO) (NTP), a well-known anode material, could be used as a solid wide-band gap electrolyte. Herein, a novel solid-state sodium-ion battery (SSIB) with the thickness of electrolyte up to the millimeter level is proposed. The results of the difference in charge density investigated by the first-principles calculations imply that using the NTP nanocrystals as electrolytes to transport sodium ions is feasible. Moreover, the SSIB exhibits a high initial discharge capacity of 3250 mAh g at the current density of 50 mA g. As compared with other previously reported SSIBs, our results are better than those reported and suggest that the NTP nanocrystals have potential application in SSIBs as solid electrolytes.
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http://dx.doi.org/10.1021/acsomega.1c00664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154011PMC
May 2021

Mental Health Help-Seeking and Associated Factors Among Public Health Workers During the COVID-19 Outbreak in China.

Front Public Health 2021 11;9:622677. Epub 2021 May 11.

School of Public Health, Sun Yat-sen University, Guangzhou, China.

The COVID-19 outbreak in China has created multiple stressors that threaten individuals' mental health, especially among public health workers (PHW) who are devoted to COVID-19 control and prevention work. This study aimed to investigate the prevalence of mental help-seeking and associated factors among PHW using Andersen's Behavioral Model of Health Services Use (BMHSU). A cross-sectional survey was conducted among 9,475 PHW in five provinces across China between February 18 and March 1, 2020. The subsample data of those who reported probable mental health problems were analyzed for this report ( = 3,417). Logistic and hierarchical regression analyses were conducted to examine the associations of predisposing, enabling, need, and COVID-19 contextual factors with mental health help-seeking. Only 12.7% of PHW reported professional mental help-seeking during the COVID-19 outbreak. PHW who were older, had more days of overnight work, received psychological training, perceived a higher level of support from the society, had depression and anxiety were more likely to report mental help-seeking (OR range: 1.02-1.73, all < 0.05) while those worked in Centers for Disease Control and Prevention were less likely to seek help (OR = 0.57, < 0.01). The belief that mental health issues were not the priority (64.4%), lack of time (56.4%), and shortage of psychologists (32.7%) were the most frequently endorsed reasons for not seeking help. The application of BMHSU confirmed associations between some factors and PHW's mental health help-seeking. Effective interventions are warranted to promote mental health help-seeking of PHW to ameliorate the negative impact of mental illness and facilitate personal recovery and routine work.
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http://dx.doi.org/10.3389/fpubh.2021.622677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144452PMC
June 2021

Global health effects of future atmospheric mercury emissions.

Nat Commun 2021 05 24;12(1):3035. Epub 2021 May 24.

State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, P. R. China.

Mercury is a potent neurotoxin that poses health risks to the global population. Anthropogenic mercury emissions to the atmosphere are projected to decrease in the future due to enhanced policy efforts such as the Minamata Convention, a legally-binding international treaty entered into force in 2017. Here, we report the development of a comprehensive climate-atmosphere-land-ocean-ecosystem and exposure-risk model framework for mercury and its application to project the health effects of future atmospheric emissions. Our results show that the accumulated health effects associated with mercury exposure during 2010-2050 are $19 (95% confidence interval: 4.7-54) trillion (2020 USD) realized to 2050 (3% discount rate) for the current policy scenario. Our results suggest a substantial increase in global human health cost if emission reduction actions are delayed. This comprehensive modeling approach provides a much-needed tool to help parties to evaluate the effectiveness of Hg emission controls as required by the Minamata Convention.
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http://dx.doi.org/10.1038/s41467-021-23391-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144432PMC
May 2021

Maternal psychological stress during pregnancy and risk of congenital heart disease in offspring: A systematic review and meta-analysis.

J Affect Disord 2021 08 8;291:32-38. Epub 2021 May 8.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, Liaoning 110004, China. Electronic address:

Background The relationship between maternal psychological stress during pregnancy and risk of congenital heart disease (CHD) in offspring is still unclear. We conducted a meta-analysis to quantitatively evaluate the association. Methods Literature search was performed through May 2020 using PubMed and Web of Science databases. Observational studies evaluating the associations of maternal psychological stress including stress, stress life events, anxiety and depression with CHD risk in offspring were eligible for the study. Results Ten case-control studies with 16,382 CHD cases and 1,812,999 non-CHD controls were included in the meta-analysis. Four studies assessed the association between maternal stress during pregnancy and CHD risk in offspring. The pooled odds ratio (OR) was 2.11 (95%CI: 1.62, 2.74) for those mothers with stress during pregnancy. Six studies assessed the association between maternal stressful life events during pregnancy and CHD risk in offspring. The pooled OR was 1.86 (95%CI: 1.29, 2.68) for those mothers exposed to stressful life events during pregnancy. Maternal anxiety and depression may not be associated with CHD risk in offspring. The pooled ORs were 1.42 (95%CI: 0.53, 3.77) and 2.10 (95%CI: 0.46, 9.59) for the maternal anxiety and depression during pregnancy, respectively. Limitations Residual confounding, heterogeneity and publication bias may exist, which may limit the interpretation of the results. Conclusion Maternal stress and stressful life events during pregnancy may be associated with higher risk of CHD in offspring, but such association was not observed for other mental health exposures such as anxiety and depression.
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http://dx.doi.org/10.1016/j.jad.2021.05.002DOI Listing
August 2021

Acute exacerbation of chronic subjective tinnitus: a cross-sectional study.

Chin Med J (Engl) 2021 02 22;134(10):1242-1244. Epub 2021 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, China.

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http://dx.doi.org/10.1097/CM9.0000000000001382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143764PMC
February 2021

Catalytic fast pyrolysis of waste mixed cloth for the production of value-added chemicals.

Waste Manag 2021 May 29;127:141-146. Epub 2021 Apr 29.

Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences (CAS), Guangzhou 510640, PR China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), 511458, PR China; CAS Key Laboratory of Renewable Energy, Guangzhou 510640, PR China; Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, PR China.

In the present study, catalytic fast pyrolysis of waste mixed cloth in an ex-situ method using hierarchical HZSM and commercial CaO was investigated. Pyrolysis of waste mixed cloth in a temperature range of 450 °C to 750 °C mainly allowed for the formation of levoglucosan without any catalysts. The utilization of HZSM with Brønsted/Lewis acid sites on micro- and mesoporous structures significantly contributed to monocyclic/dicyclic chemicals production, mainly referring to monoaromatics and naphthalene-based derivatives, especially in the case of high heating rates and catalyst usages. Furthermore, CaO revealed strong deoxygenation performance for the transformation of waste mixed cloth into low oxygen-containing chemicals, such as ketones, aliphatic hydrocarbons and aromatics. The present research thus highlights a feasible route for the catalytic upgrading of waste mixed cloth into some kinds of value-added chemicals.
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http://dx.doi.org/10.1016/j.wasman.2021.04.036DOI Listing
May 2021

HIV incidence and sexual behavioral correlates among 4578 men who have sex with men (MSM) in Chengdu, China: a retrospective cohort study.

BMC Public Health 2021 04 26;21(1):802. Epub 2021 Apr 26.

School of Public Health, Sun Yat-sen University (North Campus), No.74, Zhongshan second road, Guangzhou, China.

Background: The prevalence of HIV among men who have sex with men (MSM) in southwest China is still increasing. This study aimed to investigate the trend in HIV incidence and its associated risk factors among MSM in Chengdu, China.

Method: Incidence data were collected from the largest local non-governmental organization (NGO) serving MSM in Chengdu between 2012 and 2018, while information on sexual behaviors was collected from 2014. All MSM who received voluntary counseling and testing services (VCT) in the collaborating NGO at least twice during the study period were included. We calculated the HIV incidence density among MSM every 2 years and the overall incidence rate. A Cox proportional hazards regression model was employed to identify risk factors for HIV infection.

Result: A total of 4578 HIV-negative participants were included in the cohort. The total incidence density was 5.95 (95% CI: 5.37-6.56)/100 person-years (PYs) between 2012 and 2018. The segmented incidence density was 9.02 (95% CI: 7.46-10.78), 5.85 (95% CI: 4.86-6.97), 5.43 (95% CI: 4.53-6.46), and 3.09 (95% CI: 2.07-4.41)/100 PYs in 2012-2013, 2014-2015, 2016-2017, and 2018, respectively. After adjusting for sociodemographic characteristics, compared to participants without sexual partners within 6 months, MSM with one fixed partner (Adjusted Hazard Ratio, AHR = 1.18, 95% CI: 0.44-3.19) and more than five partners (AHR = 2.24, 95% CI: 0.81-6.20) had increased risk of HIV infection. MSM who used condom inconsistently had a higher risk of HIV infection (AHR = 1.87, 95% CI: 1.46-2.38) compared to consistent condom users.

Conclusion: The decreased HIV incidence density among MSM was potentially related to the successful comprehensive HIV prevention strategies in Chengdu. Multiple male sexual partnerships and inconsistent condom use during anal intercourse were risk factors associated with HIV occurrence.
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http://dx.doi.org/10.1186/s12889-021-10835-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077884PMC
April 2021

Prevalence of mental health problems and associated factors among front-line public health workers during the COVID-19 pandemic in China: an effort-reward imbalance model-informed study.

BMC Psychol 2021 Apr 12;9(1):55. Epub 2021 Apr 12.

School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China.

Background: Poor mental health status and associated risk factors of public health workers have been overlooked during the COVID-19 pandemic. This study used the effort-reward imbalance model to investigate the association between work-stress characteristics (effort, over-commitment, reward) and mental health problems (anxiety and depression) among front-line public health workers during the COVID-19 pandemic in China.

Methods: A total of 4850 valid online questionnaires were collected through a self- constructed sociodemographic questionnaire, the adapted ERI questionnaire, the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item General Anxiety Disorder Scale (GAD-7). Hierarchical logistic regression analysis was conducted to investigate the association between ERI factors and mental health problems (i.e., depression and anxiety), with reward treated as a potential moderator in such associations.

Results: The data showed that effort and over-commitment were positively associated with depression and anxiety, while reward was negatively associated with depression and anxiety. Development and job acceptance were the two dimensions of reward buffered the harmful effect of effort/over-commitment on depression and anxiety, whereas esteem was non-significant.

Conclusions: This study confirmed the harmful effects of effort and over-commitment on mental health among public health workers during the COVID-19 pandemic in China. Such effects could be alleviated through an appropriate reward system, especially the development and job acceptance dimensions of such a system. These findings highlight the importance of establishing an emergency reward system, comprising reasonable work-allocation mechanism, bonuses and honorary titles, a continuous education system and better career-development opportunities.
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http://dx.doi.org/10.1186/s40359-021-00563-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040352PMC
April 2021

Gender Specificity of Spousal Concordance in the Development of Chronic Disease among Middle-Aged and Older Chinese Couples: A Prospective Dyadic Analysis.

Int J Environ Res Public Health 2021 03 11;18(6). Epub 2021 Mar 11.

Department of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.

This study aimed to explore the gender specificity of spousal concordance in the development of chronic diseases among middle-aged and older Chinese couples. Data of 3420 couples were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Multivariate logistic regression was used to analyze the incidence of chronic disease development over 4 years, conditional on the spousal baseline chronic disease status; and stepwise adjusting for the couples' sociodemographic characteristics (i.e., age, education, retirement status and household income), and their individual lifestyle (i.e., smoking, drinking, exercise, social participation and BMI) all measured at baseline. The incidence of chronic diseases after 4 years of follow-up was 22.95% in the husbands (605/2636) and 24.71% in the wives (623/2521). Taking the couples' baseline sociodemographic and lifestyle covariates into account, husbands whose wife had chronic diseases at baseline showed an increased risk of developing chronic diseases over 4 years (OR = 1.24, 95%CI: 1.02, 1.51), but this risk was not statistically-significant for wives (OR = 0.88, 95%CI: 0.71, 1.08). Our study identified gender specificity of spousal concordance in the development of chronic diseases among middle-aged and older Chinese couples. This finding may contribute to the design of couple-based intervention for disease prevention and management for community-dwelling older adults.
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http://dx.doi.org/10.3390/ijerph18062886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002052PMC
March 2021

Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis.

Bioorg Med Chem Lett 2021 06 26;41:127997. Epub 2021 Mar 26.

Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China. Electronic address:

Resistance phenomena during chemotherapy of tumor has been severely hampering the applications of chemotherapeutics. Due to advantage of drug repurposing, discovery of new chemosensitizers based on approved drugs is an effect strategy to find new candidates. Herein, we found antidepressant drug - sertraline, could sensitize drug-resistant gastric cancer cell (SGC-7901/DDP) with the IC value of 18.73 μM. To understand the structure-activity relationship and improve the activity, 30 derivatives were synthesized and evaluated. The IC value of the best compound was improved to 5.2 μM. Moreover, we found apoptosis induction and cell cycle arrest was the reason for the cell death of the drug-resistant cells after treatment of sertraline and derivatives, and PI3K/Akt/mTOR pathway was involved.
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http://dx.doi.org/10.1016/j.bmcl.2021.127997DOI Listing
June 2021

The association of vertically integrated care with health care use and outcomes.

Health Serv Res 2021 Mar 17. Epub 2021 Mar 17.

Schaeffer Center for Health Policy and Economics, Sol Price School of Public Policy, University of Southern California, Los Angeles, California, USA.

Objective: To determine whether vertically integrated hospital and skilled nursing facility (SNF) care is associated with more efficient use of postdischarge care and better outcomes.

Data Sources: Medicare provider, beneficiary, and claims data from 2012 to 2014.

Study Design: We compared facility characteristics, quality of care, and health care use for hospital-based SNFs and "virtually integrated" SNFs (defined as freestanding SNFs with close referral relationships with a single hospital) relative to nonintegrated freestanding SNFs. Among patients admitted to integrated SNFs, we estimated differences in health care use and outcomes for patients originating from the parent hospital (ie, receiving vertically integrated care) versus other hospitals using linear regressions that included SNF fixed effects. We estimated bounds for our main estimates that incorporated potential omitted variables bias.

Data Extraction Methods: We identified hospital-based SNFs based on provider data. We defined virtually integrated SNFs based on patient flows between hospitals and SNFs. We identified SNF episodes, preceding hospital stays, patient characteristics, health care use, and patient outcomes using Medicare data.

Principal Findings: Consistent with prior research, integrated SNFs performed better on quality measures and health care use relative to nonintegrated SNFs (eg, hospital-based SNFs had 11-day shorter stays compared with nonintegrated SNFs adjusting for patient characteristics, P < .001). Stroke patients admitted to hospital-based SNFs from the parent hospital had shorter preceding hospital stays (adjusted difference: -1.2 days, P = .001) and shorter initial SNF stays (adjusted difference: -2.7 days, P = .049); estimates were attenuated but still robust accounting for potential omitted variables bias. For stroke patients, associations between vertically integrated care and other outcomes were either statistically insignificant or not robust to accounting for potential omitted variables bias.

Conclusions: Vertically integrated hospital and SNF care was associated with shorter hospital and SNF stays. However, there were few beneficial associations with other outcomes, suggesting limited coordination benefits from vertical integration.
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http://dx.doi.org/10.1111/1475-6773.13642DOI Listing
March 2021

The Effects of Accountable Care Organizations Forming Preferred Skilled Nursing Facility Networks on Market Share, Patient Composition, and Outcomes.

Med Care 2021 04;59(4):354-361

School of Public Health, University of Minnesota, Minneapolis, MN.

Background: Through participation in payment reforms such as bundled payment and accountable care organizations (ACOs), hospitals are increasingly financially responsible for health care use and adverse health events occurring after hospital discharge. To improve management and coordination of postdischarge care, ACO hospitals are establishing a closer relationship with skilled nursing facilities (SNFs) through the formation of preferred SNF networks.

Research Design: We evaluated the effects of preferred SNF network formation on care patterns and outcomes. We included 10 ACOs that established preferred SNF networks between 2014 and 2015 in the sample. We first investigated whether hospitals "steer" patients to preferred SNFs by examining the percentage of patients sent to preferred SNFs within each hospital before and after network formation. We then used a difference-in-difference model with SNF fixed effects to evaluate the changes in patient composition and outcomes of preferred SNF patients from ACO hospitals after network formation relative to patients from other hospitals.

Results: We found that preferred network formation was not associated with higher market share or better outcomes for preferred SNF patients from ACO hospitals. However, we found a small increase in the average number of Elixhauser comorbidities for patients from ACO hospitals after network formation, relative to patients from non-ACO hospitals.

Conclusions: After preferred SNF network formation, there is some evidence that ACO hospitals sent more complex patients to preferred SNFs, but there was no change in the volume of patients received by these SNFs. Furthermore, preferred network formation was not associated with improvement in patient outcomes.
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http://dx.doi.org/10.1097/MLR.0000000000001493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959004PMC
April 2021

Factors Influencing Depression and Mental Distress Related to COVID-19 Among University Students in China: Online Cross-sectional Mediation Study.

JMIR Ment Health 2021 Feb 22;8(2):e22705. Epub 2021 Feb 22.

Centre for Health Behaviours Research, Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Background: The COVID-19 epidemic may elevate mental distress and depressive symptoms in various populations in China.

Objective: This study investigates the levels of depression and mental distress due to COVID-19, and the associations between cognitive, behavioral, and psychosocial factors, and depression and mental distress due to COVID-19 among university students in China.

Methods: A large-scale online cross-sectional study (16 cities in 13 provinces) was conducted among university students from February 1 to 10, 2020, in China; 23,863 valid questionnaires were returned. The Patient Health Questionnaire-9 was used to assess depression. Structural equation modeling was performed to test mediation and suppression effects.

Results: Of the 23,863 participants, 47.1% (n=11,235) reported high or very high levels of one or more types of mental distress due to COVID-19; 39.1% (n=9326) showed mild to severe depression. Mental distress due to COVID-19 was positively associated with depression. All but one factor (perceived infection risks, perceived chance of controlling the epidemic, staying at home, contacted people from Wuhan, and perceived discrimination) were significantly associated with mental distress due to COVID-19 and depression. Mental distress due to COVID-19 partially mediated and suppressed the associations between some of the studied factors and depression (effect size of 6.0%-79.5%).

Conclusions: Both mental distress due to COVID-19 and depression were prevalent among university students in China; the former may have increased the prevalence of the latter. The studied cognitive, behavioral, and psychosocial factors related to COVID-19 may directly or indirectly (via mental distress due to COVID-19) affect depression. Interventions to modify such factors may reduce mental distress and depressive symptoms during the COVID-19 epidemic.
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http://dx.doi.org/10.2196/22705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901598PMC
February 2021

Human Glucagon Expression Is under the Control of miR-320a.

Endocrinology 2021 Mar;162(3)

Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA.

Increased glucagon is a hallmark of diabetes and leads to worsening of the hyperglycemia, but the molecular mechanisms causing it are still unknown. We therefore investigated the possibility that microRNAs might be involved in the regulation of glucagon. Indeed, analysis of the glucagon 3' untranslated region (UTR) revealed potential binding sites for miR-320a, and using luciferase reporter assays we found that miR-320a directly targets the 3' UTRs of human and rodent glucagon. In addition, endogenous glucagon mRNA and protein expression as well as glucagon secretion were reduced in response to miR-320a overexpression, whereas inhibition of miR-320a upregulated glucagon expression. Interestingly, miR-320a expression was decreased by high glucose, and this was associated with an increase in glucagon expression in human islets and mouse αTC1-6 cells. Moreover, miR-320a overexpression completely blunted these effects. Importantly, miR-320a was also significantly downregulated in human islets of subjects with type 2 diabetes and this was accompanied by increased glucagon expression. Thus, our data suggest that glucose-induced downregulation of miR-320a may contribute to the paradoxical increase in glucagon observed in type 2 diabetes and reveal for the first time that glucagon expression is under the control by a microRNA providing novel insight into the abnormal regulation of glucagon in diabetes.
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http://dx.doi.org/10.1210/endocr/bqaa238DOI Listing
March 2021

Association between relationship characteristics and willingness to use PrEP among same-sex male couples: a cross-sectional actor-partner analysis in Guangzhou, China.

Int J STD AIDS 2021 Mar 8;32(3):228-238. Epub 2021 Feb 8.

Department of Medical Statistics & Sun Yat-sen Global Health Institute, School of Public Health and Institute of State Governance, 26469Sun Yat-sen University, Guangzhou, China.

The association between relationship characteristics and pre-exposure prophylaxis (PrEP) acceptability among same-sex male couples has been limitedly examined. Dyadic survey data of 139 concordant HIV-negative same-sex male couples in Guangzhou, China were collected. The willingness to use PrEP was measured assuming that the participant's partner was HIV-positive. The actor-partner interdependence model was used to examine how one's relationship characteristics affected the PrEP willingness of the subject and his partner. Most participants (79.5%) were willing to use PrEP. The two individuals of the couple were distinguished by sex role in relationship, namely one usually playing the insertive role and the other usually playing the receptive role in anal intercourse. The former was labeled as "top" and the latter labeled as "bottom". The PrEP willingness of the top partner increased when he would think his partner is having sex with other people if the partner requests condom use in relationship (AOR: 5.74, 95% CI: 1.10-29.87), and decreased when his partner would get violent upon condom use requests in relationship (AOR: 0.19, 95% CI: 0.04-0.88). The PrEP willingness of the bottom partner increased when he trusted his partner (AOR: 1.13, 95% CI: 1.02-1.25) and when he or his partner disclosed the relationship to parents (AOR: 10.57, 95% CI: 1.91-58.61). Considering the sex role and relationship characteristics in couple-based interventions are important to optimize PrEP uptake among HIV-discordant same-sex male couples.
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http://dx.doi.org/10.1177/0956462420953007DOI Listing
March 2021

Social Support and Tinnitus Distress: The Importance of Developing Positive Psychological Qualities in Patients with Chronic Tinnitus.

Audiol Neurootol 2021 4;26(4):246-256. Epub 2021 Feb 4.

Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China,

Introduction: The role of social support in the relief of tinnitus distress and related mechanisms remains unclear. This study aimed to confirm a hypothesis that the influence of social support on tinnitus distress is mediated by resilience and self-esteem.

Methods: The Social Support Rating Scale, Connor-Davidson Resilience Scale, Positive Version of Rosenberg Self-Esteem Scale, and Tinnitus Handicap Inventory were used to assess 296 patients who experience chronic subjective tinnitus. The collected data were subjected to correlational analysis, mediating effect testing, and structural equation model analysis using R 3.3.1 with the mediate and lavaan packages.

Results: The result showed that social support had significant positive correlations with resilience and self-esteem, while resilience and self-esteem had significant negative correlations with tinnitus distress. Furthermore, social support indirectly affected tinnitus distress through the full mediating effects of resilience and self-esteem and could indirectly affect resilience through the partial mediating effects of self-esteem.

Conclusion: These results suggested that the key to social support for alleviating tinnitus distress lies in the development of patients' resilience and self-esteem. Promoting the development of positive psychological quality of tinnitus patients and improving their perception of social support may become the new approaches of clinical management of tinnitus.
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http://dx.doi.org/10.1159/000511254DOI Listing
February 2021

Characterization of Mutations and Prediction of PZA Resistance in Clinical Isolates From Chongqing, China.

Front Microbiol 2020 11;11:594171. Epub 2021 Jan 11.

Central Laboratory, Chongqing Public Health Medical Center, Chongqing, China.

Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH. Since resistance to pyrazinamide is primary mediated by mutation of , an alternative way of PZA susceptibility test is to analyze the pyrazinamidase activities of clinical isolates. Therefore, a database containing the full spectrum of mutations along with pyrazinamidase activities will be beneficial. To characterize mutations of in from Chongqing, China, the gene was sequenced and analyzed in 465 clinical isolates. A total of 124 types of mutations were identified in 424 drug-resistant isolates, while no mutation was identified in the 31 pan-susceptible isolates. Ninety-four of the 124 mutations had previously been reported, and 30 new mutations were identified. Based on reported literatures, 294 isolates could be predicted resistant to pyrazinamide. Furthermore, pyrazinamidase activities of the 30 new mutations were tested using the gene knockout strain. The results showed that 24 of these new mutations (28 isolates) led to loss of pyrazinamidase activity and six (8 isolates) of them did not. Taken together, 322 isolates with mutations could be predicted to be PZA resistant among the 424 drug-resistant isolates tested. Analysis of mutations and their effects on pyrazinamidase activity will not only enrich our knowledge of comprehensive mutations related with PZA resistance but also facilitate rapid molecular diagnosis of pyrazinamide resistance in .
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http://dx.doi.org/10.3389/fmicb.2020.594171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832174PMC
January 2021

Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100.

J Nanobiotechnology 2021 Jan 11;19(1):20. Epub 2021 Jan 11.

Department of Dermatology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214000, Jiangsu, China.

Background: Accumulating evidence shows that mesenchymal stem cell-derived extracellular vesicles (EVs) hold great promise to promote hair growth. However, large-scale production of EVs is still a challenge. Recently, exosome-mimetic nanovesicles (NV) prepared by extruding cells have emerged as an alternative strategy for clinical-scale production. Here, ReNcell VM (ReN) cells, a neural progenitor cell line was serially extruded to produce NV.

Results: ReN-NV were found to promote dermal papilla cell (DPC) proliferation. In addition, in a mouse model of depilation-induced hair regeneration, ReN-NV were injected subcutaneously, resulting in an acceleration of hair follicle (HF) cycling transition at the site. The underlying mechanism was indicated to be the activation of Wnt/β-catenin signaling pathway. Furthermore, miR-100 was revealed to be abundant in ReN-NV and significantly up-regulated in DPCs receiving ReN-NV treatment. miR-100 inhibition verified its important role in ReN-NV-induced β-catenin signaling activation.

Conclusion: These results provide an alternative agent to EVs and suggest a strategy for hair growth therapy.
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http://dx.doi.org/10.1186/s12951-020-00757-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802142PMC
January 2021

Working conditions and health status of 6,317 front line public health workers across five provinces in China during the COVID-19 epidemic: a cross-sectional study.

BMC Public Health 2021 01 9;21(1):106. Epub 2021 Jan 9.

School of Public Health, Sun Yat-sen University, No. 74, Zhongshan Second Road, Guangzhou, 510080, China.

Background: Public health workers at the Chinese Centre for Disease Control and Prevention (China CDC) and primary health care institutes (PHIs) were among the main workers who implemented prevention, control, and containment measures. However, their efforts and health status have not been well documented. We aimed to investigate the working conditions and health status of front line public health workers in China during the COVID-19 epidemic.

Methods: Between 18 February and 1 March 2020, we conducted an online cross-sectional survey of 2,313 CDC workers and 4,004 PHI workers in five provinces across China experiencing different scales of COVID-19 epidemic. We surveyed all participants about their work conditions, roles, burdens, perceptions, mental health, and self-rated health using a self-constructed questionnaire and standardised measurements (i.e., Patient Health Questionnaire and General Anxiety Disorder scale). To examine the independent associations between working conditions and health outcomes, we used multivariate regression models controlling for potential confounders.

Results: The prevalence of depression, anxiety, and poor self-rated health was 21.3, 19.0, and 9.8%, respectively, among public health workers (27.1, 20.6, and 15.0% among CDC workers and 17.5, 17.9, and 6.8% among PHI workers). The majority (71.6%) made immense efforts in both field and non-field work. Nearly 20.0% have worked all night for more than 3 days, and 45.3% had worked throughout the Chinese New Year holiday. Three risk factors and two protective factors were found to be independently associated with all three health outcomes in our final multivariate models: working all night for >3 days (multivariate odds ratio [ORm]=1.67~1.75, p<0.001), concerns about infection at work (ORm=1.46~1.89, p<0.001), perceived troubles at work (ORm=1.10~1.28, p<0.001), initiating COVID-19 prevention work after January 23 (ORm=0.78~0.82, p=0.002~0.008), and ability to persist for > 1 month at the current work intensity (ORm=0.44~0.55, p<0.001).

Conclusions: Chinese public health workers made immense efforts and personal sacrifices to control the COVID-19 epidemic and faced the risk of mental health problems. Efforts are needed to improve the working conditions and health status of public health workers and thus maintain their morale and effectiveness during the fight against COVID-19.
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http://dx.doi.org/10.1186/s12889-020-10146-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794632PMC
January 2021

Effect of potassium on the pyrolysis of biomass components: Pyrolysis behaviors, product distribution and kinetic characteristics.

Waste Manag 2021 Feb 1;121:255-264. Epub 2021 Jan 1.

Chongqing Environment&Sanitation Group CO., LTD, Chongqin 401121, China.

Potassium is an inorganic mineral element in biomass and has a significant catalytic effect on biomass pyrolysis. In this work, the effect of potassium on the pyrolysis of biomass components (cellulose, xylan and lignin) was investigated with the help of thermogravimetric analyzer coupled to fourier transform infrared spectrometer (TG-FTIR) and pyrolysis-gas chromatography coupled to mass spectrometry (Py-GC/MS). The results showed that potassium accelerated the start of the main pyrolysis stage of the biomass components, reduced the weight loss rate for cellulose and lignin, and increased the weight loss rate for xylan. On the other hand, potassium presented a promotion effect on the formation of char for cellulose but a suppression effect for lignin. In addition, an increasing potassium content promoted the release of volatile products for xylan. Product distribution analysis found that potassium promoted the scission of glycosidic bonds and the decomposition of glucose units, resulting in a sharp yield decrease of carbohydrates and a yield increase of furans, aldehydes and ketones. In addition, an increased production of CO was obtained, indicating that potassium favors the cleavage and reforming of carboxyl (COOH) and carbonyl (CO) groups. Furthermore, the effect of potassium on the pyrolysis of cellulose and xylan was stronger than that on lignin pyrolysis. The effect on the pyrolysis reaction also resulted in a higher activation energy for the decomposition of biomass components, especially at high temperature intervals. Moreover, the higher the content of potassium added, the greater the increase was in the activation energy.
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http://dx.doi.org/10.1016/j.wasman.2020.12.023DOI Listing
February 2021

Human Glucagon Expression Is under the Control of miR-320a.

Endocrinology 2021 Mar;162(3)

Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA.

Increased glucagon is a hallmark of diabetes and leads to worsening of the hyperglycemia, but the molecular mechanisms causing it are still unknown. We therefore investigated the possibility that microRNAs might be involved in the regulation of glucagon. Indeed, analysis of the glucagon 3' untranslated region (UTR) revealed potential binding sites for miR-320a, and using luciferase reporter assays we found that miR-320a directly targets the 3' UTRs of human and rodent glucagon. In addition, endogenous glucagon mRNA and protein expression as well as glucagon secretion were reduced in response to miR-320a overexpression, whereas inhibition of miR-320a upregulated glucagon expression. Interestingly, miR-320a expression was decreased by high glucose, and this was associated with an increase in glucagon expression in human islets and mouse αTC1-6 cells. Moreover, miR-320a overexpression completely blunted these effects. Importantly, miR-320a was also significantly downregulated in human islets of subjects with type 2 diabetes and this was accompanied by increased glucagon expression. Thus, our data suggest that glucose-induced downregulation of miR-320a may contribute to the paradoxical increase in glucagon observed in type 2 diabetes and reveal for the first time that glucagon expression is under the control by a microRNA providing novel insight into the abnormal regulation of glucagon in diabetes.
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http://dx.doi.org/10.1210/endocr/bqaa238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814302PMC
March 2021

Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling.

Ann Transl Med 2020 Nov;8(22):1524

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.

Background: Our prior studies have shown that inflammation may play an important triggering role during the process of denervated muscle atrophy. The nonsteroidal anti-inflammatory drug aspirin exhibits the effect of anti-inflammatory factors. This study will investigate the protective effect of aspirin on denervated muscle atrophy and the underlying mechanism.

Methods: Mouse models of denervated muscle atrophy were established. The protective effect of aspirin (20 mg/kg/d, i.p.) on denervated muscle atrophy was analyzed using the wet weight ratio of tibialis anterior (TA) muscle and muscle fiber cross-sectional area (CSA). The levels of inflammatory factors were detected using quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) and Signal transducer and activator of transcription 3 (STAT3) signaling pathway and the muscle fiber type related proteins in TA muscle after denervation were analyzed by western blot assay.

Results: Intraperitoneal injection of aspirin (20 mg/kg/d) effectively alleviated denervation-induced muscle atrophy. This mainly manifested as follows: The wet weight ratio of TA muscle and muscle fiber CSA of mice treated with aspirin were significantly greater compared with mice treated with normal saline. The level of myosin heavy chain (MHC) increased, and the levels of muscle specific E3 ubiquitin ligase Muscle-specific RING finger-1 (MuRF-1) and muscle atrophy F-box (MAFbx) were decreased. Mitochondrial vacuolation and autophagy were inhibited, as evidenced by reduced level of autophagy related proteins PINK1, BNIP3, LC3B and Atg7 in mice treated with aspirin compared with mice treated with saline. In addition, aspirin treatment inhibited the slow-to-fast twitch muscle fiber conversion, which were related with triggering the expression of Sirt1 and PGC-1α. Moreover, aspirin reduced the levels of inflammatory factors interleukin-6, interleukin-1β and tumor necrosis factor-α and decreased the activation of STAT3 signaling pathway.

Conclusions: This is the first study to find that aspirin can alleviate denervation-induced muscle atrophy and inhibit the type I-to-type II muscle fiber conversion and mitophagy possibly through regulating the STAT3 inflammatory signaling pathway and Sirt1/PGC-1α signal axis. This study expands our knowledge regarding the pharmacological function of aspirin and provides a novel strategy for prevention and treatment of denervated muscle atrophy.
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http://dx.doi.org/10.21037/atm-20-5460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729378PMC
November 2020

Prevalence and associated factors of sexualized drug use in sex work among transgender women sex workers in China.

AIDS Care 2020 Dec 1:1-9. Epub 2020 Dec 1.

JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China.

Sexualized drug use (SDU) is associated with a higher risk of HIV transmission. There is a dearth of study investigating the association between sex work characteristics and SDU in sex work among transgender women sex workers. To address these gaps, we conducted a secondary analysis of a cross-sectional study among 220 transgender women sex workers in Shenyang, China. The prevalence of SDU in sex work was 20.9% in the past month. After adjustment for age, HIV status, education, monthly income and duration of stay in Shenyang, performing sex work mainly in hotel rooms, charging higher per episode of commercial sex, depressive symptoms and anxiety symptoms were associated with higher likelihood of SDU in sex work. Future SDU prevention programmes SDU targeting transgender women sex workers should focus on those who charged higher and performed sex work in hotel rooms, and integrate mental health promotion as an essential component.
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http://dx.doi.org/10.1080/09540121.2020.1851017DOI Listing
December 2020

The potential effects of clinical antidiabetic agents on SARS-CoV-2.

J Diabetes 2021 Mar 19;13(3):243-252. Epub 2020 Dec 19.

Department of Medicinal Chemistry, College of Pharmacy, Army Medical University, Chongqing, China.

Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is currently posing significant threats to public health worldwide. It is notable that a substantial proportion of patients with sever COVID-19 have coexisting diabetic conditions, indicating the progression and outcome of COVID-19 may relate to diabetes. However, it is still unclear whether diabetic treatment principles can be used for the treatment of COVID-19.

Methods: We conducted a computational approach to screen all commonly used clinical oral hypoglycemic drugs to identify the potential inhibitors for the main protease (M ) of SARS-CoV-2, which is one of the key drug targets for anti-COVID-19 drug discovery.

Results: Six antidiabetic drugs with docking scores higher than 8.0 (cutoff value), including repaglinide, canagliflozin, glipizide, gliquidone, glimepiride, and linagliptin, were predicted as the promising inhibitors of M . Interestingly, repaglinide, one of the six antidiabetic drugs with the highest docking score for M , was similar to a previously predicted active molecule nelfinavir, which is a potential anti-HIV and anti-COVID-19 drug. Moreover, we found repaglinide shared similar docking pose and pharmacophores with a reported ligand (N3 inhibitor) and nelfinavir, demonstrating that repaglinide would interact with M in a similar way.

Conclusion: These results indicated that these six antidiabetic drugs may have an extra effect on the treatment of COVID-19, although further studies are necessary to confirm these findings.
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http://dx.doi.org/10.1111/1753-0407.13135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753367PMC
March 2021

Distance dependent energy transfer dynamics from a molecular donor to a zeolitic imidazolate framework acceptor.

Phys Chem Chem Phys 2020 Nov;22(44):25445-25449

Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201, USA.

Zeolitic Imidazolate frameworks (ZIFs) have been demonstrated as promising light harvesting and photocatalytic materials for solar energy conversion. To facilitate their application in photocatalysis, it is essential to develop a fundamental understanding of their light absorption properties and energy transfer dynamics. In this work, we report distance-dependent energy transfer dynamics from a molecular photosensitizer (RuN3) to ZIF-67, where the distance between RuN3 and ZIF-67 is finely tuned by depositing an ultrathin Al2O3 layer on the ZIF-67 surface using an atomic layer deposition (ALD) method. We show that energy transfer time decreases with increasing distance between RuN3 and ZIF-67 and the Förster radius is estimated to be 14.4 nm.
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http://dx.doi.org/10.1039/d0cp03995kDOI Listing
November 2020
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