Publications by authors named "Jing Du"

618 Publications

Autophagy Promotes Cigarette Smoke-Initiated and Elastin-Driven Bronchitis-Like Airway Inflammation in Mice.

Front Immunol 2021 22;12:594330. Epub 2021 Mar 22.

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Cigarette smoke (CS)-induced macrophage activation and airway epithelial injury are both critical for the development of chronic obstructive pulmonary disease (COPD), while the eventual functions of autophagy in these processes remain controversial. We have recently developed a novel COPD mouse model which is based on the autoimmune response sensitized by CS and facilitated by elastin. In the current study, we therefore utilized this model to investigate the roles of autophagy in different stages of the development of bronchitis-like airway inflammation. Autophagic markers were increased in airway epithelium and lung tissues, and or mice exhibited reduced neutrophilic airway inflammation and mucus hyperproduction in this COPD mouse model. Moreover, treatment of an autophagic inhibitor 3-methyladenine (3-MA) either during CS-initiated sensitization or during elastin provocation significantly inhibited the bronchitis-like phenotypes in mice. Short CS exposure rapidly induced expression of matrix metallopeptidase 12 (MMP12) in alveolar macrophages, and treatment of doxycycline, a pan metalloproteinase inhibitor, during CS exposure effectively attenuated the ensuing elastin-induced airway inflammation in mice. CS extract triggered MMP12 expression in cultured macrophages, which was attenuated by autophagy impairment ( or ) or inhibition (3-MA or Spautin-1). These data, taken together, demonstrate that autophagy mediates both the CS-initiated MMP12 activation in macrophages and subsequent airway epithelial injury, eventually contributing to development COPD-like airway inflammation. This study reemphasizes that inhibition of autophagy as a novel therapeutic strategy for CS-induced COPD.
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http://dx.doi.org/10.3389/fimmu.2021.594330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019710PMC
March 2021

Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor.

Neurochem Res 2021 Apr 5. Epub 2021 Apr 5.

School of Medicine, Yunnan University, 2 Cuihu North Road, Kunming, 650091, Yunnan, People's Republic of China.

Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in metabolism diseases. However, little research has been focused on the effect of GAA in neuroinflammation and the related mechanism. In the present study, lipopolysaccharide(LPS)-stimulated BV2 microglial cells were used to evaluate the anti-inflammatory capacity of GAA. Our data showed that GAA significantly suppressed LPS-induced BV2 microglial cells proliferation and activation in vitro. More strikingly, GAA promoted the conversion of BV2 microglial cells from M1 status induced by LPS to M2 status. Furthermore, GAA inhibited the pro-inflammatory cytokines release and promoted neurotrophic factor BDNF expression in LPS-induced BV2 microglial cells. Finally, we found that the expression of farnesoid-X-receptor (FXR) was prominently downregulated in LPS-stimulated BV2 microglial cells, antagonism of FXR with z-gugglesterone and FXR siRNA can reverse the effect of GAA in LPS-induced BV2 microglial cells. Taking together, our findings demonstrate that GAA can significantly inhibit LPS-induced neuroinflammation in BV2 microglial cells via activating FXR receptor.
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http://dx.doi.org/10.1007/s11064-021-03303-3DOI Listing
April 2021

How Do Instant Messages Reduce Psychological Withdrawal Behaviors?-Mediation of Engagement and Moderation of Self-Control.

Int J Environ Res Public Health 2021 Mar 14;18(6). Epub 2021 Mar 14.

School of Economics and Management School, Wuhan University, Wuhan 430072, China.

Enabling people to send and receive short text-based messages in real-time, instant messaging (IM) is a communication technology that allows instantaneous information exchanges. The development of technology makes IM communication widely adopted in the workplace, which brings a series of changes for modern contemporary working life. Based on the conservation of resource theory (COR), this paper explores the mechanism of workplace IM communication on employees' psychological withdrawal, and investigates the mediating role of work engagement in the relationship and the moderating role of self-control. Using the experience sampling method (ESM), a 10-consecutive workdays daily study was conducted among 66 employees. By data analysis of 632 observations using SPSS and HLM, results found that: (1) IM demands had a positive relation with emotion and cognitive engagement. (2) Emotion and cognitive engagement were negatively correlated with psychological withdrawal. (3) Emotion and cognitive engagement mediated the relations of IM demands and psychological withdrawal. (4) Self-control moderated the relationship between emotional engagement and psychological withdrawal.
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http://dx.doi.org/10.3390/ijerph18062983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999327PMC
March 2021

Retracted: Anticancer Activity of Metformin, an Antidiabetic Drug, Against Ovarian Cancer Cells Involves Inhibition of Cysteine-Rich 61 (Cyr61)/Akt/Mammalian Target of Rapamycin (mTOR) Signaling Pathway.

Med Sci Monit 2021 Mar 25;27:e932331. Epub 2021 Mar 25.

Department of Obstetrics and Gynecology, Liaocheng People's Hospital, Liaocheng, Shandong, China (mainland).

An editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures. Reference: Fengli Zhang, Huixiao Chen, Jing Du, Bin Wang, Lixiao Yang: Anticancer Activity of Metformin, an Antidiabetic Drug, Against Ovarian Cancer Cells Involves Inhibition of Cysteine-Rich 61 (Cyr61)/Akt/Mammalian Target of Rapamycin (mTOR) Signaling Pathway. Med Sci Monit 2018; 24: 6093-6101. 10.12659/MSM.909745.
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http://dx.doi.org/10.12659/MSM.932331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009266PMC
March 2021

Five new species of Phaonia Robineau-Desvoidy (Diptera: Muscidae) from China.

Authors:
Wanqi Xue Jing DU

Zootaxa 2020 Dec 17;4895(4):zootaxa.4895.4.6. Epub 2020 Dec 17.

Institute of Entomology, Shenyang Normal University, Shenyang 110034, China..

Five new species of Phaonia are described from China, namely P. sunqiia Xue Du sp. nov., P. zhangjunyui Xue Du sp. nov., P. liujiayui Xue sp. nov., P. wangpingga Xue sp. nov. and P. tianmushanensis Xue sp. nov. The available keys to the three species-groups where the new species belong were updated.
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http://dx.doi.org/10.11646/zootaxa.4895.4.6DOI Listing
December 2020

Lineage Switch in an Infant B-Lymphoblastic Leukemia With t(1;11)(p32;q23); , Following Blinatumomab Therapy.

Pediatr Dev Pathol 2021 Mar 22:10935266211001308. Epub 2021 Mar 22.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.

We report a 6 month-old infant girl with t(1;11)(p32;q23), -rearranged B-acute lymphoblastic leukemia (B-ALL) that was refractory to traditional ALL-directed chemotherapy. Following administration of blinatumomab, she experienced lineage switch from B-ALL to acute myeloid leukemia (AML). Myeloid-directed chemotherapy resulted in clearance of AML by flow cytometry, though a residual CD19+ B-ALL population persisted (0.14%). Following bridging blinatumomab, the patient achieved B-ALL and AML remission, as measured by flow cytometry. The patient subsequently underwent allogeneic hematopoietic stem cell transplant. Unfortunately, she relapsed with CD19+ B-ALL one-month post-transplantation. Next generation sequencing study of IGH/IGL using ClonoSEQ® analysis detected 3 dominant sequences all present in her original B-ALL, lineage switched AML, and post-transplant relapsed B-ALL, though the latter showed an additional 4 sequences, three of which were present at low abundance in the original diagnostic sample. The presence of the same clones throughout her disease course suggests cellular reprogramming and differentiation following chemotherapy and immunotherapy. This is the first reported case of lineage switch of B-ALL with t(1;11) and also the first report of a lineage switch case that used ClonoSEQ® to define the clonality of the original B-ALL, lineage switched AML, and relapsed B-ALL.
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http://dx.doi.org/10.1177/10935266211001308DOI Listing
March 2021

Prevalence and factors associated with depressive and anxiety symptoms in a Chinese population with and without cardiovascular diseases.

J Affect Disord 2021 Mar 10;286:241-247. Epub 2021 Mar 10.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University; National Clinical Research Center for Cardiovascular Diseases, Beijing, China. Electronic address:

Background: Few data have reported the prevalence of depressive and anxiety symptoms in patients with cardiovascular disease (CVD) in China. Our study aimed to estimate the prevalence and related risk factors of these mental health symptoms.

Methods: A total of 47841 participants from seven regions of China were enrolled by a two-stage, stratified, community-based, clustering sampling strategy between 2014 and 2016. Data of sociodemographic status and medical history were collected through a standard questionnaire. The Center for Epidemiologic Studies Depression Scale and Zung's self-rating anxiety scale were used to screen depressive and anxiety symptoms.

Results: Among 47588 individuals who completed the self-report questionnaires, the weighted prevalence of depressive symptom was 2.9% and that of anxiety symptom was 1.5%. In females with heart failure (HF) and stroke, prevalence of either depressive and anxiety symptoms were 15.1% and 13.8%, respectively; while 9.4% and 8.4% for the male counterparts. Among patients with ≥ any 3 specific CVDs, the prevalence of having either depressive or anxiety symptoms were 13.1% and 6.8% for females and males, respectively. Younger age, female, unmarried, lower income, and disease history of atrial fibrillation, HF and stroke tend to link with higher risks of mental health symptoms.

Limitations: Cross-sectional study.

Conclusion: A high proportion of patients with CVD had depressive and anxiety symptoms. Screening for mental health symptoms is more important in higher-risk populations who are at younger age, being female, unmarried, with low income, and with diagnoses of atrial fibrillation, HF, and stroke.
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http://dx.doi.org/10.1016/j.jad.2021.02.006DOI Listing
March 2021

Relieving ammonia nitrogen inhibition in high concentration anaerobic digestion of rural organic household waste by Prussian blue analogue nanoparticles addition.

Bioresour Technol 2021 Jun 12;330:124979. Epub 2021 Mar 12.

Jiangsu Academy of Agriculture Sciences, Nanjing 210014, China; East China Scientific Observing and Experimental Station of Development and Utilization of Rural Renewable Energy, Ministry of Agriculture and Rural Affairs, Nanjing 210014, China. Electronic address:

The application of Prussian blue analogue nanoparticles in anaerobic digestion was firstly used to evaluate the removal effect of ammonia nitrogen inhibition in anaerobic digestion. We have successfully prepared Prussian blue analogue nanoparticles, which has a high adsorption capacity of ammonia nitrogen in anaerobic digestion is 71.09 mg/g. The high concentration anaerobic digestion of rural organic household waste was not successful because of the serious inhibition of ammonia nitrogen. After adding Prussian blue analogue nanoparticles, the methane production of each group increased greatly, up to 302.22 ml/gVS. The concentration of ammonia nitrogen in anaerobic digestion decreased to 1700.77 mg/l. Prussian blue analogue nanoparticles have a good application prospect in high concentration anaerobic digestion of rural organic household waste enriched with a high concentration of ammonia nitrogen.
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http://dx.doi.org/10.1016/j.biortech.2021.124979DOI Listing
June 2021

[Concentration Levels and Potential Ecological Risks of Current Use Pesticides in the Surface Seawater of Typical Liaoning Sea Areas].

Huan Jing Ke Xue 2021 Apr;42(4):1772-1780

Key Laboratory of Marine Biological Resources and Ecology, Liaoning Ocean and Fisheries Science Research Institute, Dalian 116023, China.

Fourteen current-use pesticides (CUPs) in the surface seawaters of the typical Liaoning sea areas were analyzed using HPLC-MS/MS. The concentrations, distribution, and ecological risks were studied, as well as their source appointments using principal component analysis (PCA). The results revealed that seven types of CUPs were detected in the surface seawaters of the typical Liaoning sea areas. The total concentrations of these CUPs ranged from 16.7 ng·L to 176.1 ng·L. The samples with high concentrations were collected mostly from the estuary, and the concentrations of CUPs in the western Liaodong Bay were generally higher than those in the northeastern Yellow Sea. Atrazine and triadimenol were the predominant CUPs, and their contribution rates accounted for 56.0% and 34.5%, respectively. The PCA results indicated that six types of CUPs might be caused by the runoff from farmlands and the wastewater discharge from the chemical pesticide factory, and fruit planting could be a substantial contributor to the single component acetochlor. Atrazine and acetochlor posed medium-high ecological risks to the microalgae, while all the seven types of CUPs showed relatively lower risks to invertebrates and fish.
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http://dx.doi.org/10.13227/j.hjkx.202008125DOI Listing
April 2021

Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system.

Brain Res Bull 2021 Mar 8;171:16-24. Epub 2021 Mar 8.

Yunnan University, School of Medicine, 2 Cuihu North Road, Kunming, Yunnan, 650091, PR China. Electronic address:

Major depressive disorder (MDD) is a prevalent, chronic, and recurrent disease. At least one-third of patients have treatment-resistant depression; therefore, there is an urgent need for novel drug development. Cumulative studies have suggested an inflammatory mechanism for the pathophysiology of MDD. Ganoderma lucidum polysaccharides (GLP) is an anti-inflammatory and immunomodulatory agent. Here, we found that an injection of GLP led to a rapid and robust antidepressant effect after 60 min in the tail suspension test. This antidepressant effect remained after 5 days of treatment with GLP in the forced swim test. Unlike psychostimulants, GLP did not show a hyperactive effect in the open field test. After 60 min or 5 days of treatment, GLP exhibited an antidepressant effect in a chronic social defeat stress (CSDS) depression animal model. Moreover, after 5 days of treatment, GLP attenuated the expression of the proinflammatory cytokines IL-1β and TNF-α, enhanced the expression of the anti-inflammatory cytokine IL-10 and the neurotrophic factor BDNF, and inhibited the activation of microglia and proliferation of astrocytes in the hippocampus of CSDS mice. In addition, after 5 days of treatment, GLP significantly enhanced GluA1 S845 phosphorylation as well as GluA1 and GluA2 expression levels in the hippocampus of CSDS mice. To determine whether the antidepressant effect was mediated by Dectin-1, we found that GLP treatment enhanced Dectin-1 expression in the hippocampus in CSDS mice, and the Dectin-1-specific inhibitor laminarin almost completely blocked the antidepressant effect of GLP. This study identified GLP, an agonist of Dectin-1, as a novel and rapid antidepressant with clinical potential and multiple beneficial mechanisms, particularly in regulating the neuroimmune system and, subsequently, AMPA receptor function.
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http://dx.doi.org/10.1016/j.brainresbull.2021.03.002DOI Listing
March 2021

Point Cloud Semantic Segmentation Network Based on Multi-Scale Feature Fusion.

Sensors (Basel) 2021 Feb 26;21(5). Epub 2021 Feb 26.

Computer Engineering College, Jimei University, Xiamen 361021, China.

The semantic segmentation of small objects in point clouds is currently one of the most demanding tasks in photogrammetry and remote sensing applications. Multi-resolution feature extraction and fusion can significantly enhance the ability of object classification and segmentation, so it is widely used in the image field. For this motivation, we propose a point cloud semantic segmentation network based on multi-scale feature fusion (MSSCN) to aggregate the feature of a point cloud with different densities and improve the performance of semantic segmentation. In our method, random downsampling is first applied to obtain point clouds of different densities. A Spatial Aggregation Net (SAN) is then employed as the backbone network to extract local features from these point clouds, followed by concatenation of the extracted feature descriptors at different scales. Finally, a loss function is used to combine the different semantic information from point clouds of different densities for network optimization. Experiments were conducted on the S3DIS and ScanNet datasets, and our MSSCN achieved accuracies of 89.80% and 86.3%, respectively, on these datasets. Our method showed better performance than the recent methods PointNet, PointNet++, PointCNN, PointSIFT, and SAN.
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http://dx.doi.org/10.3390/s21051625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956681PMC
February 2021

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial Dysfunction.

Front Oncol 2020 1;10:595524. Epub 2021 Feb 1.

Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

CISD2, a NEET protein that coordinates 2Fe-2S clusters through its CDGSH domain, is critical for normal development and iron homeostasis. CISD2 plays an important role in Fe-S cluster transfer and promotes cancer proliferation. However, its specific role in the development of non-small cell lung cancer (NSCLC) remains unclear. Bioinformatics of pan-cancer analysis from The Cancer Genome Atlas show that CISD2 has an aberrant expression in most types of human cancers. Moreover, CISD2 expression is associated with a higher hazard ratio and exhibits significantly poorer overall survival in lung adenocarcinoma (LUAD), uveal melanoma, head and neck squamous cell carcinoma, brain lower grade glioma, kidney chromophobe, and liver hepatocellular carcinoma. Further investigation revealed that CISD2 is highly expressed in LUAD and LUSC, which is associated with clinical pathological stages. In addition, survival data collected from GSE31210 and GSE13213, two datasets from the NCBI Gene Expression Omnibus, also confirmed that high CISD2 expression is associated with unfavorable survival in patients with LUAD. A cell-based assay indicated that the knockdown of CISD2 inhibited proliferation, invasion, and migration in A549 cells. Additionally, CISD2 knockdown accelerated the accumulation of cellular and mitochondrial reactive oxygen species, destroying the mitochondrial morphology and function. Moreover, CISD2 inhibition activated the iron starvation response, thus, accelerating iron accumulation in A549 cells. Pretreatment with DFO, the iron chelator, blocked mitochondrial dysfunction in CISD2-knockdown cells. Collectively, the present study provides novel insights into the regulatory role of CISD2 in NSCLC and presents a potential target to improve antitumor activity based on oxidative stress.
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http://dx.doi.org/10.3389/fonc.2020.595524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882736PMC
February 2021

[NCTD Retards AML HL60 Cell Proliferation via Targeting Hedgehog/SOX2 axis].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Feb;29(1):32-37

Department of Hematology, Cancer Research Institute, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China E-mail:

Objective: To investigate the effect of norcantharidin (NCTD) to proliferation of leukemia cells through disrupting key regulators of sonic Hedgehog (SHH) pathway and its downstream transcription factor SOX2.

Methods: CCK8 was used to detected the HL60 and NB4 cells after inhibited by NCTD, SMO and GLI1 inhibitor for 24 hours. Expression level of SMO, GLI1 and SOX2 in HL60 cells with NCTD treatment was detected by immunoblot. HL60 cells were transfected with pcDNA3.1 plasmid expressing GLI1 or SOX2. Empty vector and pcDNA3. 1-EGFP were divided into negative and positive control group, respectively. The expression of exogenous GLI1 or SOX2 in HL60 cells was confirmed by immunoblot, and growth curve of HL60 cell was checked by CCK8. Proliferation of genetic modified HL60 cells treated by various dose of NCTD was detected.

Results: NCTD, SMO/GLI1 inhibitors could inhibit the proliferation of NB4 and HL60 cells in a dose-dependent manner. Compared with solvent (DMSO)-treated control group, NCTD remarkably decreased protein level of SMO, GLI1 and SOX2. GLI1 and SOX2 were overexpressed in HL60 cells as compared with pcDNA3.1 empty vector-transfected group. Growth curve demonstrated significant proliferative advantage of GLI1/SOX2-transfected cells. CCK8 assay indicated that GLI1/SOX2-overexpressed HL60 cells were more resistant to NCTD treatment.

Conclusion: NCTD attenuates HL60 proliferation via targeting the Hedgehog/SOX2 axis.
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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.01.005DOI Listing
February 2021

Co-expression network analysis identifies innate immune signatures for Albizia julibrissin saponin active fraction-adjuvanted avian influenza vaccine.

Int Immunopharmacol 2021 Apr 4;93:107417. Epub 2021 Feb 4.

College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Lin'an 311300, China. Electronic address:

Albizia julibrissin saponin active fraction (AJSAF) is a promising adjuvant candidate, but its innate immune response mechanisms remain unclear. Here, the quadriceps muscles from the mice injected intramuscularly with AJSAF alone or in combination with ovalbumin and avian influenza vaccine (rL-H5) were subjected to gene microarray. Antigen- and AJSAF-related modules with intramodular hub genes were identified and functionally analyzed using weighted gene co-expression network analysis (WGCNA) and gene set enrichment analysis (GSEA). AJSAF induced early innate immune responses at the injection site, characterized by cytokine production and neutrophil recruitment. AJSAF mainly elicited the expression of "Th1 immune response" and "Neutrophils" genes such as CCL2, CXCL1, CXCL5, IL-1β, IL-6, IL-33, S100A8, and S100A9, whereas these two gene sets were negatively enriched for rL-H5. AJSAF-specific long noncoding RNAs MIRT1 and MIRT2 could function as inflammatory mediators, whereas function unknown TINCR was co-expressed with immune response genes including CCL2, CCL4, CCL7, CSF3, CXCL5, IL-33, S100A8, and S100A9. Finally, the innate immune molecular mechanisms of adjuvant action of AJSAF and the potential signatures were proposed. These findings expanded the current knowledge on the mechanisms of action of saponin-based adjuvants.
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http://dx.doi.org/10.1016/j.intimp.2021.107417DOI Listing
April 2021

Label-free separation of nanoscale particles by an ultrahigh gradient magnetic field in a microfluidic device.

Nanoscale 2021 Feb;13(7):4029-4037

Laboratory of Biomedical Microsystems and Nano Devices, Bionic Sensing and Intelligence Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, China. and CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, 518055 Shenzhen, China.

The need for fast and accurate analysis of low-concentration species is ubiquitous nowadays. The separation and purification techniques restrict the highly sensitive detection of low-abundance nanoparticles. On the other hand, the commonly used separation techniques of labeling procedures limit their implementation in various applications. We report a microfluidic system with ultrahigh magnetic field for the label-free separation of nanoscale particles. Using high-permeability alloys and on-chip integrated magnetic micro-pole arrays, the external strong magnetic field can be conducted into the microfluidic device to form a magnetic field of high intensity and gradient, therefore separating particles of nanometer size with high efficiency. An ultrahigh gradient magnetic field greater than 105 T m-1 can be generated in the separation channel. Moreover, a negative magnetophoretic technique to separate nanoparticles is established in this device. Then, the label-free separation of nanoparticles is achieved in this microfluidic system perfused by a ferrofluid with an extremely low concentration (0.01%). A mixture of 0.2 μm and 1 μm particles is used to verify the performance of the device, where the recovery rate of 0.2 μm particles is 88.79%, and the purity reaches 94.72%. Experimental results show that the device can efficiently separate nanoscale particles with ultrahigh resolution, and in future, it may develop into a versatile and robust tool for the separation and purification of the biological samples of nanometer size.
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http://dx.doi.org/10.1039/d0nr08383fDOI Listing
February 2021

2020 update on human coronaviruses: One health, one world.

Med Nov Technol Devices 2020 Dec 29;8:100043. Epub 2020 Aug 29.

Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.

Since human coronavirus (HCoVs) was first described in the 1960s, seven strains of respiratory human coronaviruses have emerged and caused human infections. After the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), a pneumonia outbreak of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has represented a pandemic threat to global public health in the 21st century. Without effectively prophylactic and therapeutic strategies including vaccines and antiviral drugs, these three coronaviruses have caused severe respiratory syndrome and high case-fatality rates around the world. In this review, we detail the emergence event, origin and reservoirs of all HCoVs, compare the differences with regard to structure and receptor usage, and summarize therapeutic strategies for COVID-19 that cause severe pneumonia and global pandemic.
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http://dx.doi.org/10.1016/j.medntd.2020.100043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836940PMC
December 2020

Fungal Community and Biodeterioration Analysis of Hull Wood and Its Storage Environment of the Nanhai No. 1 Shipwreck.

Front Microbiol 2020 15;11:609475. Epub 2021 Jan 15.

Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.

The Nanhai No. 1 shipwreck is a Chinese merchant ship in the Southern Song Dynasty, and now it is stored in a huge enclosed glass warehouse in Maritime Silk Road Museum in Guangdong Province. At present, the hull of the Nanhai No. 1 shipwreck is still being excavated, and a small part of the hull wood is soaked in a specific solution to desalt. Through long-term exploration, we found that the above two states of hull wood had undergone biodeterioration, so the purpose of this study is to analyze the fungal community of exposed and soaked wood from the Nanhai No. 1 shipwreck. We sampled 10 exposed hull wood and sea mud samples, two wood storage water samples, and air samples in the glass warehouse. We used scanning electron microscope and optical microscope to find that there were obvious fungal structures in exposed wood and wood storing water samples. High-throughput sequencing of fungi revealed that the most abundant genera in exposed and soaked wood were sp., and sp., respectively. In addition, and were successfully isolated from the hull wood surface and wood storing water samples, and the degradation tests of lignin and cellulose, the sensitivity tests of biocides and growth curve assay were carried out. We also found that sp. and sp. are the most abundant in the glass warehouse air. Our research results show that and should be regarded as a major threat to the preservation of the Nanhai No. 1 shipwreck. These results provide a reference for our protection of shipwrecks and other similar artifacts.
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http://dx.doi.org/10.3389/fmicb.2020.609475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843524PMC
January 2021

Effect of family history of atrial fibrillation on recurrence after atrial fibrillation ablation: A report from the Chinese Atrial Fibrillation Registry Study.

J Cardiovasc Electrophysiol 2021 Mar 10;32(3):678-685. Epub 2021 Feb 10.

Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine for Cardiovascular Diseases, Beijing, China.

Background: To evaluate the impact of family history of atrial fibrillation (FAF) on postablation atrial tachyarrhythmia (AT) recurrence.

Methods: All the 8198 patients undergoing initial AF ablation registered in the Chinese Atrial Fibrillation Registry study were analyzed. FAF was defined as having first-degree relatives diagnosed as AF at age 65 years or younger, and before the time the case in this study was diagnosed. Cox proportional hazards models were used to evaluate the impact of FAF on postablation AT recurrence. Age, sex, body mass index, AF type, history of congestive heart failure, hypertension, diabetes mellitus, prior stroke/transient ischemic attack/systemic embolism, vascular diseases, use of contact force-sensing catheter, and completion of high school were adjusted. The definition of AT recurrence was any documented AF, atrial flutter, or AT lasting more than or equal to 30 s after 3 months blanking period.

Results: After a mean follow-up of 26.2 ± 19.6 months, 318 out of the 645 patients (49.3%) with FAF and 3339 out of the 7553 patients (44.2%) without FAF experienced AT recurrence, corresponding to annual recurrence rates of 22.8% and 20.2%, respectively. Patients with FAF had a significant higher risk of AT recurrence (adjusted hazard ratio 1.129, 95% confidence interval 1.005-1.267) in multivariable analysis. Moreover, FAF had a significant higher impact on AT recurrence in the subgroup of patients diagnosed with AF at age 50 years or younger (p for interaction = .036).

Conclusion: FAF is a risk factor for postablation AT recurrence. This is especially true in those with AF diagnosed at 50 years or younger.
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http://dx.doi.org/10.1111/jce.14919DOI Listing
March 2021

Atrial fibrillation prevalence, awareness and management in a nationwide survey of adults in China.

Heart 2021 Jan 28. Epub 2021 Jan 28.

Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China

Objective: To determine AF prevalence and gaps in atrial fibrillation (AF) awareness and management in China.

Methods: We conducted a community-based survey of 47 841 adults (age ≥45 years) in seven geographic regions of China between 2014 and 2016. Participants underwent a structured questionnaire, a standard 12-lead ECG, physical examination and blood sampling. AF prevalence, defined by either ECG detection or self-report, was estimated according to sampling weights, non-response and age and sex distribution of the population. We used multivariable logistic regression to estimate associations among sociodemographic, clinical and geographic factors with the AF prevalence, awareness and treatment.

Results: The weighted AF prevalence was 1.8% (95% CI 1.7% to 1.9%), but varied from 0.9% to 2.4% across geographical regions and equates to being present in an estimated 7.9 (95% CI 7.4 to 8.4) million people in China. Among men and women, the AF prevalence increased from 0.8% and 0.6% in the age group 45-54 years to 5.4% and 4.9% in the age group ≥75 years, respectively. Proportions of people who were aware of having AF decreased overall from 65.3% in 45-54 year-olds to 53.9% in ≥75 year-olds and varied between sex (men 58.5%, women 68.8%) and residency status (urban 78.3%, rural 35.3%). Only 6.0% of patients with high-risk AF received anticoagulation therapy.

Conclusions: AF prevalence is higher than previously reported in China, with low awareness and large treatment gaps. Large-scale efforts are urgently needed to reduce AF adverse consequences.
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http://dx.doi.org/10.1136/heartjnl-2020-317915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958113PMC
January 2021

Development of a novel multi-strain wheat Qu with high enzyme activities for Huangjiu fermentation.

J Sci Food Agric 2021 Jan 27. Epub 2021 Jan 27.

National Engineering Laboratory for Cereal Fermentation Technology (NELCF), Jiangnan University, Wuxi, P. R. China.

Background: Wheat Qu has long been used as a fermentation starter to produce Huangjiu. Wheat Qu quality depends on its microbial community structure and the hydrolytic enzymes generated by the micro-organisms.

Results: Strain YF1 and YF2 were successfully screened as they exhibited high acidic protease (231.9 ± 1.4 U g ) and cellulase (7.1 ± 0.6 U g ) activities. Based on a morphological and sequence analysis of the internal transcribed spacer (ITS) gene, YF1 and YF2 were identified as Rhizopus oryzae and Aspergillus niger, respectively. Cooked wheat Qu was produced using mixed fungal starter fermentations with Aspergillus oryzae SU-16, YF1, and YF2. For Qu-making, the optimized conditions for fermentation time, water content, and inoculum size were 47.8 h, 69.4%, and 6.1%, respectively. Under these conditions, compared with single-strain cooked wheat Qu, enzyme activities of amylase, acidic protease, and cellulase increased by 27.4%, 657.1%, and 1276.2%, respectively. Short peptides and free amino acids contents increased by 19.6% and 131.8%, respectively. This wheat Qu was used for Huangjiu brewing, and the alcohol content increased by approximately 14.6% because of the increased starch hydrolysis efficiency mainly attributed to its high enzyme activity.

Conclusion: Using mixed fungal strains as starter cultures may be an efficient strategy to improve wheat Qu quality, with great potential for application in industrial Huangjiu production. © 2021 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.11127DOI Listing
January 2021

Homozygous variants in PANX1 cause human oocyte death and female infertility.

Eur J Hum Genet 2021 Jan 25. Epub 2021 Jan 25.

Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, 200032, Shanghai, China.

PANX1, one of the members of the pannexin family, is a highly glycosylated channel-forming protein. Recently, we identified heterozygous variants in PANX1 that follow an autosomal dominant inheritance pattern and cause female infertility characterized by oocyte death. In this study, we screened for novel PANX1 variants in patients with the phenotype of oocyte death and discovered a new type of inheritance pattern accompanying PANX1 variants. We identified two novel homozygous missense variants in PANX1 [NM_015368.4 c.712T>C (p.(Ser238Pro) and c.899G>A (p.(Arg300Gln))] associated with the oocyte death phenotype in two families. Both of the homozygous variants altered the PANX1 glycosylation pattern in cultured cells, led to aberrant PANX1 channel activation, and resulted in mouse oocyte death after fertilization in vitro. It is worth noting that the destructive effect of the two homozygous variants on PANX1 function was weaker than that caused by the recently reported heterozygous variants. Our findings enrich the variational spectrum of PANX1 and expand the inheritance pattern of PANX1 variants to an autosomal recessive mode. This highlights the critical role of PANX1 in human oocyte development and helps us to better understand the genetic basis of female infertility due to oocyte death.
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http://dx.doi.org/10.1038/s41431-020-00807-4DOI Listing
January 2021

Effects of implant buccal distance on peri-implant strain: A Micro-CT based finite element analysis.

J Mech Behav Biomed Mater 2021 04 13;116:104325. Epub 2021 Jan 13.

Department of Mechanical Engineering, Pennsylvania State University, University Park, PA, USA. Electronic address:

Bone-implant mechanics is one of the factors that contribute to implant stability and success. In this work, voxel-based finite element models were built based on the micro-CT images of human cadaveric mandible specimens before and after implant placement. The computed results show high strain at the bone-implant contact locations and the buccal and lingual bone plates. The strain concentration in the thinner buccal plates was more substantial than that in the thicker lingual plates. The average values of maximum principal strain in the buccal and lingual ROIs were in good agreement with those measured using mechanical testing coupled with micro-CT and digital volume correlation. The implant position was then virtually changed in the models to be placed lingually or buccally. The computed strain in the buccal bone decreased when the implant was placed away from the buccal plate. The strain in lingual bone also deceased when the implant was moved from the center of the alveolar socket towards the lingual or buccal plate. The results indicate that the distance from implant to the buccal plate can affect the mechanical stimuli in bone, especially in the buccal plate, which may subsequently affect the bone remodeling process and buccal bone resorption.
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http://dx.doi.org/10.1016/j.jmbbm.2021.104325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933109PMC
April 2021

Activation of FXR by ganoderic acid A promotes remyelination in multiple sclerosis via anti-inflammation and regeneration mechanism.

Biochem Pharmacol 2021 Mar 20;185:114422. Epub 2021 Jan 20.

Yunnan University, School of Medicine and College of Life Sciences, 2 Cuihu North Road, Kunming, Yunnan 650091, China. Electronic address:

Multiple sclerosis (MS), as an inflammatory demyelinating disorder of central nervous system, is the leading cause of non-traumatic neurologic disability in young adults. The pathogenesis of MS remains unknown, however, a dysregulation of glia-neuroimmune signaling plays a key role during progressive disease stage. Most of the existing drugs are aimed at the immune system, but there is no approved drug by promoting remyelination after demyelination so far. There is a great interest in identifying novel agents for treating MS bytargeting to switch the immune imbalance from pro-inflammation and apoptosis to anti-inflammation and regeneration during remyelination phase. Here, we reported that ganoderic acid A (GAA) significantly enhanced the remyelination and rescued motor deficiency in two animal models of MS, including cuprizone-induced demyelination and myelin oligodendrocyte glycoprotein (MOG) 35-55-induced experimental autoimmune encephalomyelitis model. In these two independent MS animal models, GAA modulated neuroimmune to enhance the anti-inflammatory and regeneration markers IL-4 and BDNF, inhibited inflammatory markers IL-1β and IL-6, followed by down-regulation of microglia activation and astrocyte proliferation. Pharmacological and genetic ablation of farnesoid-X-receptor (FXR) abolished GAA-induced remyelination and restoration of motor deficiency in MS mice. Thus, GAA is a novel and potential therapeutic agent that can rescue MS neuroimmune imbalance and remyelination through an FXR receptor-dependent mechanism. Clinical investigation on the therapeutic effect of GAA in improving remyelination of the MS patients to rescue the motor function is warranted.
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http://dx.doi.org/10.1016/j.bcp.2021.114422DOI Listing
March 2021

Catheter ablation for atrial fibrillation is associated with reduced risk of mortality in the elderly: a prospective cohort study and propensity score analysis.

J Geriatr Cardiol 2020 Dec;17(12):740-749

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing, China.

Background: It is unclear whether catheter ablation (CA) for atrial fibrillation (AF) affects the long-term prognosis in the elderly. This study aims to evaluate the relationship between CA and long-term outcomes in elderly patients with AF.

Methods: Patients more than 75 years old with non-valvular AF were prospectively enrolled between August 2011 and December 2017 in the Chinese Atrial Fibrillation Registry Study. Participants who underwent CA at baseline were propensity score matched (1:1) with those who did not receive CA. The outcome events included all-cause mortality, cardiovascular mortality, stroke/transient ischemic attack (TIA), and cardiovascular hospitalization.

Results: Overall, this cohort included 571 ablated patients and 571 non-ablated patients with similar characteristics on 18 dimensions. During a mean follow-up of 39.75 ± 19.98 months (minimum six months), 24 patients died in the ablation group, compared with 60 deaths in the non-ablation group [hazard ratio (HR) = 0.49, 95% confidence interval (CI): 0.30-0.79, = 0.0024]. Besides, 6 ablated and 29 non-ablated subjects died of cardiovascular disease (HR = 0.25, 95% CI: 0.11-0.61, = 0.0022). A total of 27 ablated and 40 non-ablated patients suffered stroke/TIA (HR = 0.79, 95% CI: 0.48-1.28, = 0.3431). In addition, 140 ablated and 194 non-ablated participants suffered cardiovascular hospitalization (HR = 0.84, 95% CI: 0.67-1.04, = 0.1084). Subgroup analyses according to gender, type of AF, time since onset of AF, and anticoagulants exposure in initiation did not show significant heterogeneity.

Conclusions: In elderly patients with AF, CA may be associated with a lower incidence of all-cause and cardiovascular mortality.
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http://dx.doi.org/10.11909/j.issn.1671-5411.2020.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762700PMC
December 2020

linc-AAM Facilitates Gene Expression Contributing to Macrophage Activation and Adaptive Immune Responses.

Cell Rep 2021 Jan;34(1):108584

Key Laboratory of Animal Virology of Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address:

Although various long noncoding RNAs (lncRNAs) are specifically expressed in activated macrophages, their in vivo functions and mechanisms of action are largely unexplored. Here, we identify a long intergenic noncoding RNA associated with activated macrophage (linc-AAM) and elucidate its function and mechanisms. linc-AAM is highly expressed in activated macrophages. In vitro function analysis reveals that linc-AAM facilitates macrophage activation and promotes the expression of immune response genes (IRGs). In mechanisms, linc-AAM interacts with heterogeneous nuclear ribonucleoprotein L (hnRNPL) via two CACACA motifs, resulting in its dissociation from histone H3 to activate chromatin and facilitate transcription of IRGs. Of note, linc-AAM knockout (KO) mice manifest impaired antigen-specific cellular and humoral immune responses to ovalbumin (OVA) in vivo. Altogether, the results uncover a mechanism of lncRNA in modulating hnRNPL function and confirm that linc-AAM acts as a transcription enhancer to activate macrophages and promote adaptive immunity.
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http://dx.doi.org/10.1016/j.celrep.2020.108584DOI Listing
January 2021

Her2-Targeted Multifunctional Nano-Theranostic Platform Mediates Tumor Microenvironment Remodeling and Immune Activation for Breast Cancer Treatment.

Int J Nanomedicine 2020 9;15:10007-10028. Epub 2020 Dec 9.

Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Purpose: The treatment of breast cancer is often ineffective due to the protection of the tumor microenvironment and the low immunogenicity of tumor cells, leading to a poor therapeutic effect. In this study, we designed a nano-theranostic platform for these obstacles: a photothermal effect mediated by a gold shell could remodel the tumor microenvironment by decreasing cancer-associated fibroblasts (CAFs) and promote the release of doxorubicin (DOX) from nanoparticles. In addition, it could realize photoacoustic (PA)/MRI dual-model imaging for diagnose breast cancer and targeted identification of Her2-positive breast cancer.

Methods: Her2-DOX-superparamagnetic iron oxide nanoparticles (SPIOs)@Poly (D, L-lactide-co-glycolide) acid (PLGA)@Au nanoparticles (Her2-DSG NPs) were prepared based on a single emulsion oil-in-water (O/W) solvent evaporation method, gold seed growing method, and carbon diimide method. The size distribution, morphology, PA/MRI imaging, drug loading capacity, and drug release were investigated. Cytotoxicity, antitumor effect, cellular uptake, immunogenic cell death (ICD) effect, and targeted performance on human Her2-positive BT474 cell line were investigated in vitro. BT474/Adr cells were constructed and the antitumor effect of NPs on it was evaluated in vitro. Moreover, chemical-photothermal therapy effect, PA/MRI dual-model imaging, ICD effect induced by NPs, and tumor microenvironment remodeling in human BT474 breast cancer nude mice model were also investigated.

Results: Nanoparticles were spherical, uniform in size and covered with a gold shell. NPs had a photothermal effect, and can realize photothermal-controlled drug release in vitro. Chemical-photothermal therapy had a good antitumor effect on BT474/Adr cells and on BT474 cells in vitro. The targeting evaluation in vitro showed that Her2-DSG NPs could actively target and identify Her2-positive tumor cells. The PA/MRI imaging was successfully validated in vitro/vivo. Similarly, NPs could enhance the ICD effect in vitro/vivo, which could activate an immune response. Immunofluorescence results also proved that photothermal effect could decrease CAFs to remodel the tumor microenvironment and enhance the accessibility of NPs to tumor cells. According to the toxicity results, targeted drug delivery combined with photothermal-responsive drug release proved that NPs had good biosafety in vivo. Chemical-photothermal therapy of Her2-targeted NPs has a good antitumor effect in the BT474 nude mice model.

Conclusion: Our study showed that chemical-photothermal therapy combined with tumor microenvironment remodeling and immune activation based on the Her2-DSG NPs we developed are very promising for Her2-positive breast cancer.
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http://dx.doi.org/10.2147/IJN.S271213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756023PMC
January 2021

Tandem mass tag-based quantitative proteomic profiling of the serum of patients with abnormal uterine bleeding associated with copper intrauterine device.

Int J Gynaecol Obstet 2020 Dec 22. Epub 2020 Dec 22.

NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Pharmacy, Fudan University, Shanghai, China.

Objective: To investigate changes in the level of protein in serum and uncover the underlying pathogenesis of abnormal uterine bleeding (AUB) associated with copper intrauterine devices (Cu IUD).

Methods: Protein profiles were investigated via tandem mass tag (TMT)-based quantitative proteomics and bioinformatics technology. Quantification and characterization of candidate proteins were further performed in 33 controls and 45 cases by Luminex assay and enzyme-linked immunosorbent assay.

Results: In total, 842 proteins were identified via TMT coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the serum of individuals with IUDs. Among them, 25 differentially expressed proteins (p < 0.05) were observed, including eight upregulated proteins and 17 downregulated proteins. Ten proteins were verified, and Alpha-1-Antitrypsin (a1AT) had a significantly elevated expression in women with AUB associated with the Cu IUD compared with healthy controls (p = 0.026) and a high area under the curve value (0.656), as well as sensitivity (64.9%) and specificity (71.9%).

Conclusion: This is the first study to explore changes in serum protein and the underlying mechanisms of AUB associated with the Cu IUD via TMT technology. a1AT with biomarker potential was validated. These findings might provide an experimental basis for the early diagnosis or treatment of AUB associated with the Cu IUD.
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http://dx.doi.org/10.1002/ijgo.13562DOI Listing
December 2020

Precise Molecular-Level Modification of Nafion with Bismuth Oxide Clusters for High-performance Proton-Exchange Membranes.

Angew Chem Int Ed Engl 2021 Mar 28;60(11):6076-6085. Epub 2021 Jan 28.

Key Lab of Polyoxometalate Science of Ministry of Education, Key Laboratory of Nanobiosensing and Nanobioanalys, Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.

Fabricating proton exchange membranes (PEMs) with high ionic conductivity and ideal mechanical robustness through regulation of the membrane microstructures achieved by molecular-level hybridization remains essential but challenging for the further development of high-performance PEM fuel cells. In this work, by precisely hybridizing nano-scaled bismuth oxide clusters into Nafion, we have fabricated the high-performance hybrid membrane, Nafion-Bi -3 %, which showed a proton conductivity of 386 mS cm at 80 °C in aqueous solution with low methanol permeability, and conserved the ideal mechanical and chemical stabilities as PEMs. Moreover, molecular dynamics (MD) simulation was employed to clarify the structural properties and the assembly mechanisms of the hybrid membrane on the molecular level. The maximum current density and power density of Nafion-Bi -3 % for direct methanol fuel cells reached to 432.7 mA cm and 110.2 mW cm , respectively. This work provides new insights into the design of versatile functional polymer electrolyte membranes through polyoxometalate hybridization.
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http://dx.doi.org/10.1002/anie.202012079DOI Listing
March 2021