Publications by authors named "Jing Cheng"

931 Publications

LncRNA serves as a competing endogenous RNA of to upregulate in papillary thyroid carcinoma.

Arch Endocrinol Metab 2022 Aug 4. Epub 2022 Aug 4.

Department of Pathology, Affiliated 3201 Hospital of Xi'an Jiaotong University, Hanzhong City, Shaanxi Province, PR China.

Objective: has been characterized as an oncogenic long non-coding RNA (lncRNA) in several cancers including papillary thyroid cancer (PTC), but its role in PTC has not been fully elucidated. Considering the critical role of lncRNAs in cancer biology, further functional analysis of in PTC may provide novel insights into PTC management.

Subjects And Methods: Paired tumor and non-tumor tissues were collected from 63 papillary thyroid carcinoma (PTC) patients. Expression levels of and in tissue samples were analyzed by qRT-PCR. Cell transfection was performed to explore the interactions among and . Cell proliferation assay was performed to evaluate the effects of and on cell proliferation.

Results: accumulated to high levels in PTC tissues and was affected by clinical stage. showed a positive correlation with across PTC tissues. RNA interaction prediction showed that could bind to , which can directly target . and showed no regulatory role regulating the expression of each other, but overexpression of upregulated and enhanced cell proliferation. In contrast, overexpression of miR-218 downregulated and attenuated cell proliferation. In addition, miR-218 suppressed the role of in regulating the expression of and cell proliferation.

Conclusion: may serve as a competing endogenous RNA of to upregulate in PTC, thereby promoting cell proliferation. The pathway characterized in the present study might serve as a potential target to treat PTC.
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http://dx.doi.org/10.20945/2359-3997000000510DOI Listing
August 2022

Liquiritin inhibits H O -induced oxidative stress injury in H9c2 cells via the AMPK/SIRT1/NF-κB signaling pathway.

J Food Biochem 2022 Aug 5:e14351. Epub 2022 Aug 5.

Department of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

Heart failure (HF) is a serious disease with high mortality. Oxidative stress plays a vital role in its occurrence and development. Licorice is commonly used to treat HF in traditional Chinese medicine. Liquiritin, the main ingredient of licorice, has antioxidant and anti-inflammatory properties, but the mechanism against oxidative stress in cardiomyocytes has not been reported. Establishment of oxidative damage model in H9c2 cells by hydrogen peroxide (H O ). Liquiritin (5, 10, 20 μmol/L) could significantly prevent the loss of cell viability and decrease the apoptosis rate. It can reduce the levels of reactive oxygen species (ROS), malonedialdehyde (MDA), lactate dehydrogenase (LDH), tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and increase the activity of ATP, superoxidedismutase (SOD), glutathione peroxide (GSH-px), glutathione reductase (GR) and catalase (CAT) to alleviate oxidative stress and inflammation in a dose-dependent manner. Liquiritin was found to be related to AMP-Activated Protein Kinase (AMPK) pathway by molecular docking. Western blotting (WB) and quantitative reverse transcription PCR (RT-qPCR) confirmed that liquiritin could promote AMPKα phosphorylation and sirtuin 1 (SIRT1) protein expression, and inhibit phosphorylation of nuclear factor kappa B p65 (NF-κB p65). Compound C, EX 527, and PDTC can reverse the effects of liquiritin, indicating that its antioxidant effect is achieved by regulating AMPK/SIRT1/NF-κB signaling pathway. PRACTICAL APPLICATIONS: Heart failure is one of the most common cardiovascular diseases, and its treatment remains a worldwide problem. Licorice is a food and dietary supplement that has been used widely in traditional Chinese medicine (TCM). Liquiritin is one of the main active components of licorice, which has antioxidant and anti-inflammatory pharmacological effects. This study revealed the mechanism of licorice against oxidative damage of H9c2 cardiomyocytes, and provided a scientific basis for liquiritin as an antioxidant in the treatment of heart failure.
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http://dx.doi.org/10.1111/jfbc.14351DOI Listing
August 2022

Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice.

Signal Transduct Target Ther 2022 Aug 1;7(1):259. Epub 2022 Aug 1.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.

Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and metalloprotease protein-17 (ADAM17). However, whether ADAM17 plays a role in the pathogenesis and intervention of DCM is obscure. In this study, we created cardiomyocyte-specific knockout of ADAM17 (A17) mice, and left ventricular dimension, function, pathology and molecular biology were assessed in ADAM17 control, A17 control, ADAM17 diabetic and A17 diabetic mice. Both differentiated H9c2 cells and neonatal rat cardiomyocytes (NRCMs) were used to explore the molecular mechanisms underlying the effect of ADAM17 on DCM. The results showed that protein expression and activity of ADAM17 were upregulated whereas the protein expression of ACE2 was downregulated in the myocardium of diabetic mice. Cardiomyocyte-specific knockout of ADAM17 mitigated cardiac fibrosis and cardiomyocyte apoptosis and ameliorated cardiac dysfunction in mice with DCM. Bioinformatic analyses detected a number of genes enriched in metabolic pathways, in particular the AMPK signaling pathway, expressed differentially between the hearts of A17 and ADAM17 diabetic mice. The mechanism may involve activated AMPK pathway, increased autophagosome formation and improved autophagic flux, which reduced the apoptotic response in cardiomyocytes. In addition, hypoxia-inducible factor-1α (HIF-1α) might act as an upstream mediator of upregulated ADAM17 and ADAM17 might affect AMPK signaling via α1 A-adrenergic receptor (ADRA1A). These results indicated that ADAM17 activity and ACE2 shedding were enhanced in DCM, which was reversed by cardiomyocyte-specific ADAM17 knockout. Thus, inhibition of ADAM17 may provide a promising approach to the treatment of DCM.
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http://dx.doi.org/10.1038/s41392-022-01054-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339545PMC
August 2022

Specific extraction of nucleic acids employing pillar[6]arene-functionalized nanochannel platforms.

Chem Commun (Camb) 2022 Jul 29. Epub 2022 Jul 29.

State Key Laboratory of Food Science and Technology, Jiangnan University, China.

The rapid extraction of high-purity nucleic acids from complex biological samples using conventional methods is complicated. Therefore, in this study, glycine-pillar[6]arene (Gly-P6)-functionalized tapered nanochannels were constructed using 32-mer single-stranded . DNA (ssDNA) as a model sequence, which can selectively transport ssDNA by multiple noncovalent forces (transport flux of 2.65 nM cm h) under the interference of amino acids and other substances. In view of these prospective results, the selective transport of nucleic acids with nanochannels could be applied in the design of nucleic acid enrichment and separation systems in the future.
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http://dx.doi.org/10.1039/d2cc02693gDOI Listing
July 2022

Evaluation of concentrated growth factor and blood clot as scaffolds in regenerative endodontic procedures: A retrospective study.

Aust Endod J 2022 Jul 25. Epub 2022 Jul 25.

Department of Paediatric Dentistry, Hubei-MOST KLOS & KLOBM, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

The study aims to investigate and compare the success rate of concentrated growth factor (CGF) and blood clot (BC) as scaffolds in regenerative endodontic procedures (REPs). Immature permanent necrotic teeth treated by REPs with at least a 6-month follow-up were included. These teeth were divided into the CGF (53 teeth) and BC (68 teeth) groups. Treatment outcomes were assessed using a combined clinical and radiographic scoring system. The total success rate was 91.74% over a mean follow-up period of 23.15 months. There was no significant difference between the CGF group (86.79%) and BC group (95.59%). The success rate of traumatic teeth (84.31%) was significantly lower than that of teeth with developmental dental anomalies (98.39%) (p < 0.05). CGF may be a suitable alternative scaffold in REPs when adequate bleeding cannot be achieved. Moreover, compared to developmental dental anomalies, traumatic teeth treated by REPs may be more vulnerable to failure.
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http://dx.doi.org/10.1111/aej.12666DOI Listing
July 2022

Pseudo-template molecularly imprinted polymeric fiber solid-phase microextraction coupled to gas chromatography for ultrasensitive determination of 2,4,6-trihalophenol disinfection by-products.

J Chromatogr A 2022 Jul 9;1678:463322. Epub 2022 Jul 9.

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address:

2,4,6-trihalorophenol disinfection by-products (DBPs) have strong toxicity to be needed for monitoring. In this study, two kind of molecularly imprinted polymeric fibers were prepared using 2,4,6-trichlorophenol as template and tricuronic phloroglucinol (MOP) as pseudo-template, respectively. The two fibers were assembled as solid phase microextraction (SPME) fiber to extract 2,4,6-trihalophenol DBPs from water and detect them by gas chromatography coupled to electron capture detector (GC-ECD). The results of F-test and t-test stated that there are significant difference in the analytical results of 2,4,6-trichlorophenol between using the fiber based on 2, 4, 6-trichlorophenol as template and MOP as pseudo-template. It was found that the carry-over of template (2,4,6-trichlorophenol) leaked from the fiber in GC thermal desorption, resulting in the wrong quantitative analytical result for 2,4,6-trichlorophenol in water. Hence, molecularly imprinted polymeric fibers based on MOP as pseudo-template was applied for the determination of 2,4,6-trihalophenol DBPs in water combined with GC-ECD. The selectivity of the fiber for 2,4,6-trihalophenol DBPs was investigated and demonstrated. Under the optimized condition, the method has much lower limit of detection (0.5-1.1 pg mL) than most reported methods. The method was applied for the determination of 2,4,6-trihalophenol DBPs in environmental water and the relative recoveries were found to be in the range from 77.1% to 105.6% and the relative standard deviation was 0.5-9.4%. 2,4,6-tribromophenol was found at concentration of 0.054 ng mL in a swimming pool.
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http://dx.doi.org/10.1016/j.chroma.2022.463322DOI Listing
July 2022

Pseudo-template molecularly imprinted polymeric fiber solid-phase microextraction coupled to gas chromatography for ultrasensitive determination of 2,4,6-trihalophenol disinfection by-products.

J Chromatogr A 2022 Jul 9;1678:463322. Epub 2022 Jul 9.

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address:

2,4,6-trihalorophenol disinfection by-products (DBPs) have strong toxicity to be needed for monitoring. In this study, two kind of molecularly imprinted polymeric fibers were prepared using 2,4,6-trichlorophenol as template and tricuronic phloroglucinol (MOP) as pseudo-template, respectively. The two fibers were assembled as solid phase microextraction (SPME) fiber to extract 2,4,6-trihalophenol DBPs from water and detect them by gas chromatography coupled to electron capture detector (GC-ECD). The results of F-test and t-test stated that there are significant difference in the analytical results of 2,4,6-trichlorophenol between using the fiber based on 2, 4, 6-trichlorophenol as template and MOP as pseudo-template. It was found that the carry-over of template (2,4,6-trichlorophenol) leaked from the fiber in GC thermal desorption, resulting in the wrong quantitative analytical result for 2,4,6-trichlorophenol in water. Hence, molecularly imprinted polymeric fibers based on MOP as pseudo-template was applied for the determination of 2,4,6-trihalophenol DBPs in water combined with GC-ECD. The selectivity of the fiber for 2,4,6-trihalophenol DBPs was investigated and demonstrated. Under the optimized condition, the method has much lower limit of detection (0.5-1.1 pg mL) than most reported methods. The method was applied for the determination of 2,4,6-trihalophenol DBPs in environmental water and the relative recoveries were found to be in the range from 77.1% to 105.6% and the relative standard deviation was 0.5-9.4%. 2,4,6-tribromophenol was found at concentration of 0.054 ng mL in a swimming pool.
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http://dx.doi.org/10.1016/j.chroma.2022.463322DOI Listing
July 2022

Green credit, environmentally induced R&D and low carbon transition: Evidence from China.

Environ Sci Pollut Res Int 2022 Jul 18. Epub 2022 Jul 18.

Faculty of Bioscience Engineering, Ghent University, Ghent, 9000, Belgium.

This paper explores the impact of green credit (Cre) on low-carbon transition (Lct) and its influence mechanisms. Theoretically, Cre promotes environmentally induced R&D (ER&D), which in turn affects Lct. Empirically, using a panel data of 30 Chinese provinces and cities from 2004 to 2019, we measure the provincial ER&D and carbon emission performance (Cep), based on which we conduct an econometric analysis. It is observed that Cre promotes Lct (that is, Cre reduces carbon emission and improves Cep). This conclusion still holds after a series of robustness tests and endogeneity treatments. And the impact of Cre on Lct is asymmetrical due to regional differences in physical and geoclimatic characteristics, income levels, and financing constraint levels. Second, ER&D is an important mechanism of action for Cre enhancing Lct. Further analysis reveals that ER&D can affect Lct through energy transition effects and green innovation effects. Finally, the positive effect of Cre on ER&D is significant in high level of Lct regions, but insignificant in low level of Lct regions. Based on this, specific policy recommendations from the perspective of developing Cre and establishing an incentive mechanism for ER&D are put forward.
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http://dx.doi.org/10.1007/s11356-022-21941-0DOI Listing
July 2022

Ginsenoside Rg3 induces apoptosis and inhibits proliferation by down-regulating TIGAR in rats with gastric precancerous lesions.

BMC Complement Med Ther 2022 Jul 15;22(1):188. Epub 2022 Jul 15.

Department of Chinese Internal Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Ginsenoside Rg3 (GRg3) is one of the main active ingredients in Chinese ginseng extract and has various biological effects, such as immune-enhancing, antitumour, antiangiogenic, immunomodulatory and anti-inflammatory effects. This study aimed to investigate the therapeutic effect of GRg3 on gastric precancerous lesion (GPL) induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and the potential mechanism of action.

Methods: The MNNG-ammonia composite modelling method was used to establish a rat model of GPL. Histopathological changes in the rat gastric mucosa were observed by pathological analysis using haematoxylin-eosin staining to assess the success rate of the composite modelling method. Alcian blue-periodic acid Schiff staining was used to observe intestinal metaplasia in the rat gastric mucosa. Apoptosis was detected in rat gastric mucosal cells by terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling staining. The production level of reactive oxygen species (ROS) was determined by the dihydroethidium fluorescent probe method, and that of TP53-induced glycolysis and apoptosis regulator (TIGAR) protein was determined by immunohistochemical staining and western blotting. The production levels of nicotinamide adenine dinucleotide phosphate (NADP) and glucose-6-phosphate dehydrogenase (G6PDH) were determined by an enzyme-linked immunosorbent assay, and that of glutathione (GSH) was determined by microanalysis.

Results: GRg3 significantly alleviated the structural disorganization and cellular heteromorphism in the form of epithelial glands in the gastric mucosa of rats with GPL and retarded the progression of the disease. Overexpression of TIGAR and overproduction of NADP, GSH and G6PDH occurred in the gastric mucosal epithelium of rats with GPL, which in turn led to an increase in the ROS concentration. After treatment with GRg3, the expression of TIGAR and production of NADP, GSH G6PDH decreased, causing a further increase in the concentration of ROS in the gastric mucosal epithelium, which in turn induced apoptosis and played a role in inhibiting the abnormal proliferation and differentiation of gastric mucosal epithelial cells.

Conclusion: Grg3 can induce apoptosis and inhibit cell proliferation in MNNG-induced GPL rats. The mechanism may be related to down-regulating the expression levels of TIGAR and production levels of GSH, NADP and G6PD, and up-regulating the concentration of ROS.
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http://dx.doi.org/10.1186/s12906-022-03669-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284801PMC
July 2022

Trends in iodine status among US children and adults: A Cross-sectional Analysis of NHANES Data from 2001-2004 to 2017-2020.

Thyroid 2022 Jul 13. Epub 2022 Jul 13.

Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, 56695, Endocrinology and Metabolism, Shanghai, China;

Background: Iodine nutrition is an important public health issue. Trends in iodine status over time among US schoolchildren and adults and factors mediating changes of iodine status were examined.

Methods: In this cross-sectional study of NHANES data, we estimated trends in US population using linear regression analyses. Representative samples of US children and adults were enrolled in NHANES 2001-2020. The NHANES cycles were categorized into five 4-year periods: 2001-2004, 2005-2008, 2009-2012, 2013-2016 and 2017-2020. The final sample sizes of children and adults for analysis were 4 288 and 19 661, respectively. The estimated average requirement(EAR)( based on guidelines from the Institute of Medicine), was used to estimate the prevalence rate of inadequate iodine intake. Binary logistic regression analyses were used to investigate the association between iodine status and contributing factors.

Results: From 2001-2004 to 2017-2020, among children, UIC decreased from 243μg/L to 166μg/L (Ptrend=0.0057) and prevalence of iodine intake below the EAR rose from 15.4% to 27.6%. In adults, the UIC decreased from 153μg/L to 116μg/L (Ptrend<0.001) and prevalence of iodine intake below the EAR rose from 15.0% to 17.9%. A higher prevalence rate of iodine intake below the EAR was observed in females compared to males (children, 24.0% vs. 16.5%, P<0.001; adults, 20.0% vs. 11.1%, P<0.001). Inadequate iodine intake was less frequent among non-Hispanic White and Hispanic compared to non-Hispanic Black in children and adults. Adults without thyroid problems had a higher prevalence of inadequate iodine intake than those with thyroid problems (16.0% vs. 13.0%, P=0.001). Inadequate iodine intake was less likely in the children who "sometimes" and "often" consumed milk products compared with children who "never or rarely" consumed milk products (OR, 0.60[0.30,1.21] and 0.24[0.13,0.43], respectively). The prevalence of inadequate iodine intake among adults reporting "sometimes" (OR 0.70[0.58, 0.83]) and "often" consuming milk products was lower than those who "never or rarely" consumed them (OR 0.36[0.30,0.44]).

Conclusions: In this weighted survey, the prevalence of inadequate iodine intake increased from 2001-2004 to 2017-2020 among US school-age children and adults. Sex, race, thyroid problems and a decreased intake of milk products were significantly associated with iodine intake below the EAR.
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http://dx.doi.org/10.1089/thy.2022.0103DOI Listing
July 2022

Circ_0110940 Exerts an Antiapoptotic and Pro-Proliferative Effect in Gastric Cancer Cells via the miR-1178-3p/SLC38A6 Axis.

J Oncol 2022 30;2022:3494057. Epub 2022 Jun 30.

Department of Gastroenterology Medicine, Lanzhou Second People's Hospital, Lanzhou 730046, Gansu, China.

Circular RNAs (circRNAs) are essential regulators in human cancers, including gastric cancer, by the miRNA/mRNA axis. A previous study identified the upregulation of circ_0110940 in human gastric cancer tissues. The present study performed assays to reveal the functions of circ_0110940 and its downstream miRNA/mRNA axis in gastric cancer cells. Traditional proliferation and apoptosis assays including colony formation, EdU staining, and Annexin V-PI staining assays were conducted. A luciferase reporter assay was performed to assess the binding between miR-1178-3p and circ_0110940 or SLC38A. We found the significant upregulation of circ_0110940 in human gastric cancer cells AGS and MKN45. Circ_0110940 was a stable circRNA and exerted an antiproliferative and proapoptotic effect in AGS and MKN45. Circ_0110940 binded with miR-1178-3p, which further targeted SLC38A6 3'UTR. Circ_0110940 degraded miR-1178-3p, and miR-1178-3p degraded SLC38A6. Thus, circ_0110940 has a positive effect on SLC38A6 expression. Furthermore, SLC38A6 rescued the effects of circ_0110940 knockdown on gastric cancer cell proliferation and apoptosis. In conclusion, circ_0110940 exerted an antiapoptotic and pro-proliferative effect in gastric cancer cells via the miR-1178-3p/SLC38A6 axis, which may provide basis for the targeted therapy of gastric cancer.
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http://dx.doi.org/10.1155/2022/3494057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262524PMC
June 2022

Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis.

Sci Rep 2022 Jul 8;12(1):11602. Epub 2022 Jul 8.

Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.

Hepatocyte nuclear factor alpha (HNF1α), endoplasmic reticulum (ER) stress, and hepatocyte apoptosis contribute to severe acute exacerbation (SAE) of liver injury. Here, we explore HNF1α-ER stress-hepatocyte apoptosis interaction in liver injury. LO2, HepG2 and SK-Hep1 cells were treated with thapsigargin (TG) or tunicamycin (TM) to induce ER stress. Carbon tetrachloride (CCl) was used to induce acute liver injury in mice. Low-dose lipopolysaccharide (LPS) exacerbated liver injury in CCl-induced mice. Significant apoptosis, HNF1α upregulation, and nuclear factor kappa B (NF-κB) activation were observed in human-derived hepatocytes during ER stress. Knockdown of Rela, NF-κB p65, inhibited the HNF1α upregulation. Following CCl treatment ER stress, apoptosis, HNF1α expression and RelA phosphorylation were significantly increased in mice. HNF1α knockdown reduced activating transcription factor 4 (ATF4) expression, and aggravated ER stress as well as hepatocyte apoptosis in vivo and in vitro. The double fluorescent reporter gene assay confirmed that HNF1α regulated the transcription of ATF4 promoter. LPS aggravated CCl-induced liver injury and reduced HNF1α, and ATF4 expression. Therefore, in combination, HNF1α and ER stress could be mutually regulated forming a feedback loop, which helps in protecting the injured liver by down-regulating hepatocyte apoptosis. Low-dose LPS aggravates hepatocyte apoptosis and promotes the SAE of liver injury by interfering with the feedback regulation of HNF1α and ER stress in acute liver injury.
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http://dx.doi.org/10.1038/s41598-022-15846-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270423PMC
July 2022

A patient with hereditary transthyretin amyloidosis involving multiple cranial nerves due to a rare p.(Phe84Ser) variant.

Transl Neurosci 2022 Jan 7;13(1):116-119. Epub 2022 Jun 7.

Department of Neurology. The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19, Nonglinxia Road, Yuexiu District, Guangzhou 510000, China.

We report a 30-year-old man involving gastrointestinal symptoms, vitreous opacity, and multiple cranial neuropathies. Transthyretin-related hereditary amyloidosis genetic testing revealed a rare c.251T > C variant p.(Phe84Ser). Only four cases with this variant have been reported before.
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http://dx.doi.org/10.1515/tnsci-2022-0219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175014PMC
January 2022

Overexpressing SIRT6 can Attenuate the Injury of Intracerebral Hemorrhage by Down-Regulating NF-kB.

Neuromolecular Med 2022 Jun 29. Epub 2022 Jun 29.

Department of Neurosurgery, Renmin Hospital of Wuhan University, 99 Zhang Zhidong Street, Wuhan, 430060, China.

Sirtuin-6 (SIRT6), a member of the sirtuins family of NAD ( +) dependent deacetylases, has been shown to have beneficial effects in ischemic stroke. However, the role of SIRT6 in intracerebral haemorrhage (ICH) has not reported. We observed that SIRT6 expression was down-regulated in human ICH patients and down-regulated in ICH-induced rat cortical neurons. We subsequently found that SIRT6 overexpression reduced brain tissue damage and increased neuronal survival in the ICH model of rats and hemin-induced cortical neurons. Our further study found that overexpression of SIRT6 can reduce inflammatory response by down-regulating the expression of NF-kB and thus promote the recovery of neurological function in ICH animals. In conclusion, SIRT6 can inhibit the expression of NF-kB and plays a neuroprotective role in ICH by inhibiting the NF-kB-mediated inflammatory response.SIRT6 could be a novel therapeutic target for ICH.
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http://dx.doi.org/10.1007/s12017-022-08715-0DOI Listing
June 2022

Preferences, use, and perceived access to flavored e-cigarettes among United States adolescents and young adults.

Drug Alcohol Depend Rep 2022 Jun 3;3. Epub 2022 Jun 3.

University of California San Francisco, San Francisco, CA, United States.

Background: Citing concern over youth use, the Food and Drug Administration announced a prioritized enforcement policy against cartridge-based (reusable pod) e-cigarettes in non-menthol, non-tobacco flavors, effective February 2020. Data are needed regarding youth e-cigarette access and use behaviors following this policy.

Methods: This cross-sectional national (USA) online panel survey, conducted March/April 2021, included 2253 participants ages 14-20 who ever used e-cigarettes ≥3 times (73% past 30-day users). Participants reported their flavor preferences, use reasons, and perceived ease of access. Latent class analysis categorized participants according to their preferred e-cigarette flavors, and multinominal logistic regression identified sociodemographic and behavioral correlates of class membership.

Results: Most past 30-day e-cigarette users used reusable pod (77%) or modern disposable (68%) devices, ≥1 non-tobacco (92%), sweet (76%), and/or menthol flavors including fruit-ice (70%) (flavor and device categories not mutually exclusive). Most past 30-day users (70%) and non-users (63%) perceived it would be somewhat or very easy to acquire e-cigarettes in flavors they like. Latent class analysis identified four e-cigarette flavor preference classes: mint (34% of sample), no preference (29%), fruit/sweet (28%), and dislikes ≥1 flavor (10%). Relative to no preference, membership in fruit/sweet (RRR: 1.87; 95% CI: 1.37, 2.57) and mint (RRR: 3.85; 95% CI: 2.77, 5.36) classes was associated with using e-cigarettes ≥50 times. Fruit/sweet membership was inversely associated with combustible tobacco use (RRR: 0.50; 95% CI: 0.38, 0.66).

Conclusion: Young e-cigarette users maintained ample access to flavored and cartridge-based products. Stronger access restrictions and enforcement are required to reduce youth e-cigarette use.
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http://dx.doi.org/10.1016/j.dadr.2022.100068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224229PMC
June 2022

Flexible porous Gelatin/Polypyrrole/Reduction graphene oxide organohydrogel for wearable electronics.

J Colloid Interface Sci 2022 Nov 9;625:197-209. Epub 2022 Jun 9.

College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China.

Conductive hydrogel-based flexible electronics have attracted immense interest in wearable sensor, soft robot and human-machine interface. However, the application of hydrogels in flexible electronics is limited by the deterioration of mechanical and electrical properties due to freezing at low temperature and desiccation after long-term use. Meanwhile, flexible electronics based on hydrogel are usually not breathable, which has a great impact on wearing comfort and signal stability in long-term sensing. In this work, an adjustable porous gelatin/polypyrrole/reduction graphene oxide (Gel/PPy/rGO) organohydrogel with high breathability (14 g∙cm∙h), conductivity (5.25 S/m), mechanical flexibility, anti-freezing and long-term stability is prepared via the combination method of biological fermentation and salt-out toughening crosslinking. The sensor fabricated from the prepared porous organohydrogel exhibits excellent sensing sensitivity, fast response ability, and good endurance, which monitors both weak and intense human activities effectively like finger bending, elbow bending, walking and running, and tiny pulse beating. A pressure sensor array prepared from the porous organohydrogel detects pressure variation in 2D sensitively. Furthermore, the porous organohydrogel is utilized as flexible electrodes for the accurate collection and recognition of human physiological signals (EMG, ECG) and as an interface between human and machine.
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http://dx.doi.org/10.1016/j.jcis.2022.06.041DOI Listing
November 2022

Renal Function in Patients Hospitalized With Anorexia Nervosa Undergoing Refeeding: Findings From the Study of Refeeding to Optimize Inpatient Gains.

J Adolesc Health 2022 Jun 12. Epub 2022 Jun 12.

Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, California.

Purpose: Among complications of malnutrition secondary to anorexia nervosa (AN) or atypical anorexia nervosa (AAN), renal impairment remains poorly elucidated. Evaluating renal function in hospitalized pediatric patients with AN and AAN undergoing refeeding will yield important information to guide clinicians in screening and managing renal dysfunction in this population.

Methods: This is a secondary analysis of data from the Study of Refeeding to Optimize Inpatient Gains trial, a multicenter randomized clinical trial comparing higher calorie refeeding versus lower calorie refeeding in 120 adolescents and young adults hospitalized with medical instability secondary to AN or AAN. Baseline disease characteristics were obtained. Vital sign measurements, weight, electrolytes, and fluid status were evaluated daily to ascertain medical stability. Renal function on admission and throughout hospitalization was quantified using daily creatinine measurement and calculation of the estimated glomerular filtration rate (eGFR) using the modified Schwartz equation. Regression analysis and mixed linear models were utilized to evaluate factors associated with eGFR.

Results: Of the 111 participants who completed treatment protocol, 33% had a baseline eGFR less than 90, suggesting renal impairment. Patients who experienced more rapid weight loss and more severe bradycardia were more likely to have low admission eGFR. While eGFR improved during refeeding, eGFR change by day based on refeeding treatment assignment did not reach statistical significance (95% confidence interval, -1.61, 0.15]; p = .095).

Discussion: Renal impairment is evident on admission in a significant number of adolescents and young adults hospitalized with AN and AAN. We demonstrate that short-term medical refeeding yields improvement in renal function.
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http://dx.doi.org/10.1016/j.jadohealth.2022.04.017DOI Listing
June 2022

Interictal dynamic network transitions in mesial temporal lobe epilepsy.

Epilepsia 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Objective: To reveal the possible routine of brain network dynamic alterations in patients with mesial temporal lobe epilepsy (mTLE) and to establish a predicted model of seizure recurrence during interictal periods.

Methods: Seventy-nine unilateral mTLE patients with hippocampal sclerosis and 97 healthy controls from two centers were retrospectively enrolled. Dynamic brain configuration analyses were performed with resting-state functional magnetic resonance imaging (MRI) data to quantify the functional stability over time and the dynamic interactions between brain regions. Relationships between seizure frequency and ipsilateral hippocampal module allegiance were evaluated using a machine learning predictive model.

Results: Compared to the healthy controls, patients with mTLE displayed an overall higher dynamic network, switching mainly in the epileptogenic regions (false discovery rate [FDR] corrected p-FDR < .05). Moreover, the dynamic network configuration in mTLE was characterized by decreased recruitment (intra-network communication), and increased integration (inter-network communication) among hippocampal systems and large-scale higher-order brain networks (p-FDR < .05). We further found that the dynamic interactions between the hippocampal system and the default-mode network (DMN) or control networks exhibited an opposite distribution pattern (p-FDR < .05). Strikingly, we showed that there was a robust association between predicted seizure frequency based on the ipsilateral hippocampal-DMN dynamics model and actual seizure frequency (p-perm < .001).

Significance: These findings suggest that the interictal brain of mTLE is characterized by dynamical shifts toward unstable state. Our study provides novel insights into the brain dynamic network alterations and supports the potential use of DMN dynamic parameters as candidate neuroimaging markers in monitoring the seizure frequency clinically during interictal periods.
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http://dx.doi.org/10.1111/epi.17325DOI Listing
June 2022

Simulation and Projection of Climate Extremes in China by a Set of Statistical Downscaled Data.

Int J Environ Res Public Health 2022 05 24;19(11). Epub 2022 May 24.

Chongqing Climate Center, Chongqing 401147, China.

This study assesses present-day extreme climate changes over China by using a set of phase 6 of the Coupled Model Intercomparison Project (CMIP6) statistical downscaled data and raw models outputs. The downscaled data is produced by the adapted spatial disaggregation and equal distance cumulative distribution function (EDCDF) method at the resolution of 0.25° × 0.25° for the present day (1961-2014) and the future period (2015-2100) under the Shared Socioeconomic Path-way (SSP) 2-4.5 than SSP5-8.5 emission scenario. The results show that the downscaling method improves the spatial distributions of extreme climate events in China with higher spatial pattern correlations, Taylor Skill Scores and closer magnitudes no matter single model or multi model ensemble (MME). In the future projections, large inter-model variability between the downscaled models still exists, particular for maximum consecutive 5-day precipitation (RX5). The downscaled MME projects that total precipitation (PTOT) and RX5, will increase with time, especially for the northwest China. The projected heavy precipitation days (R20) also increase in the future. The region of significant increase in R20 locates in the south of river Yangtze. Maxi-mum annual temperature (TXX) and percentage of warm days (TX90p) are projected to increase across the whole country with larger magnitude over the west China. Projected changes of minimum annual temperature (TNN) over the northeastern China is the most significant area. The higher of the emission scenario, the more significant of extreme climates. This reveals that the spatial distribution of extreme climate events will become more uneven in the future.
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http://dx.doi.org/10.3390/ijerph19116398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180870PMC
May 2022

and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production AKT activation.

Acta Pharm Sin B 2022 May 18;12(5):2239-2251. Epub 2021 Nov 18.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.

The potential medicinal value of Ma bamboo (), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that leaf extract (DLE) reduced fasting blood glucose levels, body weight, and low-density lipoprotein cholesterol with low liver toxicity in / mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways. Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase () and phosphoenolpyruvate carboxykinase 1 () expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor (IGF1R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients.
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http://dx.doi.org/10.1016/j.apsb.2021.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136573PMC
May 2022

Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage.

Front Neurosci 2022 12;16:888198. Epub 2022 May 12.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To investigate the association between cerebral small vessel disease (SVD) and hematoma volume in primary intracerebral hemorrhage (ICH).

Methods: Patients from a prospective ICH cohort were enrolled. Admission and follow-up CT scan within 72 h after onset were reviewed to calculate the final hematoma volume. We evaluated cortical superficial siderosis and the global SVD score, including white matter hyperintensities, lacunes, enlarged perivascular space, and cerebral microbleeds on MRI. We conducted the multivariate logistic regression analyses to explore the association between SVD markers and small ICH, as well as hematoma volume. Hematoma location was stratified into lobar and non-lobar for subgroup analysis.

Results: A total of 187 patients with primary ICH (mean age 62.4 ± 13.4 years, 67.9% male) were enrolled. 94 (50.2%) patients had small ICH. The multivariate logistic regression analysis showed an association between global SVD score and small ICH [adjusted odds ratio (aOR) 1.27, 95% CI 1.03-1.57, = 0.027] and a trend of higher global SVD score towards non-lobar small ICH (aOR 1.23, 95% CI 0.95-1.58, = 0.122). In the multivariate linear regression analysis, global SVD score was inversely related to hematoma volume of all ICH (β = -0.084, 95% CI -0.142 to -0.025, = 0.005) and non-lobar ICH (β = -0.112, 95% CI -0.186 to -0.037, = 0.004). Lacune (β = -0.245, 95% CI -0.487 to -0.004, = 0.046) was associated with lower non-lobar ICH volume.

Conclusion: Global SVD score is associated with small ICH and inversely correlated with hematoma volume. This finding predominantly exists in non-lobar ICH.
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http://dx.doi.org/10.3389/fnins.2022.888198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133886PMC
May 2022

Identification of a novel DFNA5 mutation, IVS7-2 a > G, in a Chinese family with non-syndromic sensorineural hearing loss.

Acta Otolaryngol 2022 May 31;142(5):448-453. Epub 2022 May 31.

Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China.

Background: To date, seven mutations have been reported in families with autosomal dominant non-syndromic hearing loss worldwide. All the mutations cause exon 8 skipping at the mRNA level, that led to the protein truncated and the protein could exert a gain of ototoxic function.

Objective: In this study, we found an autosomal-dominant non-syndromic hearing loss Chinese pedigree which spanned four generations and comprised 43 members. We want to identify the causative gene and mutation.

Methods: Application of microsatellite markers on DFNA 23 loci preliminary screening of 25 genes, data were analyzed by linkage analysis.

Results: We mapped the locus to the region between D7S629 and D7S516 (two-point lod-score of 5.39) with the application of 8 microsatellite markers. By direct sequencing of candidate genes in mapping region, we identified a novel missense mutation ivs7-2 A > G in DFNA5 gene, which was faithfully cosegregated with hearing loss in the family.

Conclusion And Significance: The missense mutation in intron 7 of causes skipping of exon 8, resulting in premature termination of the open reading frame. This type of mutation has repeatedly confirmed that it provides more evidence for the previous view and provides a more solid foundation for future research.
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http://dx.doi.org/10.1080/00016489.2019.1597984DOI Listing
May 2022

Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis.

Calcif Tissue Int 2022 08 26;111(2):162-170. Epub 2022 May 26.

Gastroenterology Department, Tianjin Medical University General Hospital, Tianjin, China.

Intestinal absorption of vitamin D is an important way to improve the vitamin D level in senile osteoporosis (SOP). There is a link between oral probiotics and vitamin D, but the mechanism is still unclear. We aimed to evaluate whether Lactobacillus rhamnosus GG culture supernatant (LCS) can affect cholecalciferol absorption, transport, and hydroxylation in SOP, and explore underlying mechanisms. In the study, specific-pathogen-free SAMP6 mice were randomly divided into an experimental group administered undiluted LCS and a control group administered normal drinking water. Furthermore, levels of cholecalciferol absorption were compared between Caco-2 cells cultured with varying concentrations of cholecalciferol and stimulated with LCS or de Man, Rogosa, and Sharpe (MRS) broth (control). Similarly, LCS-stimulated HepG2 cells were compared with MRS-stimulated HepG2 cells. Finally, protein levels of VD transporters in small intestine tissues and Caco-2 cells, as well as vitamin D-binding protein and 25-hydroxylase in liver tissues and HepG2 cells, were detected by western blot. The results showed that plasma concentrations of cholecalciferol and 25OHD were higher in mice of the LCS group compared with the control group, and these values were positively correlated. With the addition of LCS, cholecalciferol uptake was increased with 0.5 μM or 10 μM cholecalciferol in the medium. Protein levels of CD36 and NPC1L1 were higher in the LCS group compared with the control group, while SR-BI protein was decreased, both in vitro and in vivo. In conclusion, LCS can promotes intestinal absorption cholecalciferol by affecting protein levels of VD transporters and improves 25OHD levels in SOP.
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http://dx.doi.org/10.1007/s00223-022-00975-zDOI Listing
August 2022

Serum Exosomes MicroRNAs Are Novel Non-Invasive Biomarkers of Intrahepatic Cholestasis of Pregnancy.

Front Endocrinol (Lausanne) 2022 4;13:832577. Epub 2022 May 4.

Intensive Care Medicine, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.

Background: Intrahepatic cholestasis of pregnancy (ICP) is closely related to the occurrence of adverse outcomes. Currently, total bile acids (TBAs) are the only diagnostic index for ICP, and its sensitivity and specificity have certain limitations. In this study, we aimed to develop potential biomarkers for the diagnosis of ICP.

Methods: Sixty pregnant women diagnosed with ICP and 48 healthy pregnant controls were enrolled in this study. We used the Agilent microRNA (miRNA) array followed by quantitative reverse transcriptase polymerase chain reaction assays to identify and validate the serum exosome miRNA profiles in ICP and healthy pregnant controls. We employed bioinformatics to identify metabolic processes associated with differentially expressed serum exosome miRNAs.

Results: The expression levels of hsa-miR-4271, hsa-miR-1275, and hsa-miR-6891-5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR-6891-5p was evaluated with the area under the receiver operating characteristic curve (AUC) values of 0.861, 0.886, and 0.838, respectively. Multiple logistic regression analysis showed that a combination of the levels of hsa-miR-4271and hsa-miR-1275 afforded a significantly higher AUC (0.982). The non-error rate of a combination of all three exosome miRNAs was the highest (95%), thus more reliable ICP diagnosis. The expression levels of all three exosome miRNAs were negatively associated with TBAs. Furthermore, according to bioinformatics analysis, the three exosome miRNAs were related to lipid metabolism, apoptosis, oxidative stress, and the Mitogen Activated Protein Kinase (MAPK) signaling pathway.

Conclusions: This study may identify the novel non-invasive biomarkers for ICP and provided new insights into the important role of the exosome miRNA regulation in ICP.
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http://dx.doi.org/10.3389/fendo.2022.832577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114354PMC
May 2022

Sensitive and Rapid Diagnosis of Respiratory Virus Coinfection Using a Microfluidic Chip-Powered CRISPR/Cas12a System.

Small 2022 Jul 22;18(26):e2200854. Epub 2022 May 22.

State Key Laboratory of Membrane Biology, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.

The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 is profoundly influencing the global healthcare system and people's daily lives. The high resource consumption of coronavirus disease 2019 (COVID-19) is resulting in insufficient surveillance of coinfection or resurgence of other critical respiratory epidemics, which is of public concern. To facilitate evaluation of the current coinfection situation, a microfluidic system (MAPnavi) is developed for the rapid (<40 min) and sensitive diagnosis of multiple respiratory viruses from swab samples in a fully sealed and automated manner, in which a nested-recombinase polymerase amplification and the CRISPR-based amplification system is first proposed to ensure the sensitivity and specificity. This novel system has a remarkably low limit of detection (50-200 copies mL ) and is successfully applied to detect 171 clinical samples (98.5% positive predictive agreement; 100% negative predictive agreement), and the results identify 45.6% coinfection among clinical samples from patients with COVID-19. This approach has the potential to shift diagnostic and surveillance efforts from targeted testing for a high-priority virus to comprehensive testing of multiple virus sets and to greatly benefit the implementation of decentralized testing.
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http://dx.doi.org/10.1002/smll.202200854DOI Listing
July 2022

Fermentation-Inspired Gelatin Hydrogels with a Controllable Supermacroporous Structure and High Ductility for Wearable Flexible Sensors.

ACS Appl Mater Interfaces 2022 May 19. Epub 2022 May 19.

College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.

Supermacroporous hydrogels have attracted wide concern due to their comfort and breathability in wearable health-monitoring applications. Size controllable supermacroporous structure and excellent mechanical properties are the most important for its application. However, they are normally fabricated by the cryogelation method, which is difficult to control pore size and maintain flexibility. Here, yeast fermentation-inspired gelatin hydrogels with a controllable supermacroporous structure and excellent mechanical properties were fabricated for the first time. The pore size can be controlled by adjusting the content of glucose and yeast, the ratio of glucose to yeast, fermentation time, and gelatin content during fermentation. The hydrogels demonstrated a controllable pore size range from 100 to 400 μm and rapid swelling characteristics. The mechanical properties were maintained by soaking ammonium sulfate solution for 12 h, showing maximum tensile and compressive strains over 300 and 99%, respectively. This novel approach can be easily applied to the preparation of supermacroporous and high ductility hydrogels under mild conditions. Furthermore, conductive hydrogels combined supermacroporous structures with conductive polyaniline and reduced oxidized graphene, and silver nanowires were prepared as wearable flexible sensors. The obtained sensors maintain well-distributed porosity, breathability, and mechanical flexibility, also showing excellent conductivity of 2.4 S m. Finally, the sensors were successfully applied to detect physiological signals and human-computer interaction.
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http://dx.doi.org/10.1021/acsami.2c02524DOI Listing
May 2022

Can green finance improve carbon emission efficiency?

Environ Sci Pollut Res Int 2022 May 13. Epub 2022 May 13.

School of Economics and Management, China University of Geosciences, Wuhan, 430078, China.

This article discusses the influence and mechanism of green finance on carbon emission efficiency. Based on the panel data of 27 provinces and municipality in China from 2008 to 2017, the slack-based model of unexpected output is used to measure the efficiency of carbon emissions. On this basis, the Tobit model is used to empirically study the impact and mechanism of green finance on the efficiency of carbon emissions. The consequences exhibit that (1) China's carbon emission efficiency is not high and generally presents a gradient decreasing characteristic of east, middle, and west. (2) Overall, green finance plays a considerable role in improving carbon emission efficiency; by region and group, there are significant differences in the influence of green finance on carbon emission efficiency. (3) The study found that green finance promotes the efficiency of carbon emission through technological progress and industrial structure upgrading. This study provides empirical evidence and policy enlightenment for the realization of carbon peaking and carbon neutrality goals and the evolution of green finance.
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http://dx.doi.org/10.1007/s11356-022-20670-8DOI Listing
May 2022

High recurrence of lymphedema and influencing factors in discharged breast cancer patients during the COVID-19 pandemic: A multicenter, cross-sectional survey.

Cancer Med 2022 May 11. Epub 2022 May 11.

Public Health Section, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: There has been a delay in the detection and treatment of lymphedema in breast cancer patients during the lockdown owing to quarantine and limited social activity. Moreover, this scenario has caused psychosocial issues in these patients. Given that there is scarce information on the prevalence and influence of lymphedema during the coronavirus disease (COVID-19) pandemic, we aimed to estimate the prevalence of lymphedema recurrence and its influencing factors among discharged breast cancer patients during the COVID-19 pandemic.

Methods: This was a multicenter, cross-sectional, hospital-based survey of discharged breast cancer patients was conducted during the COVID-19 pandemic in eight first-class hospitals in Wuhan, China. The Norman Questionnaire was used to assess lymphedema. Univariable and multivariable binary logistic regression analyses were performed to identify factors influencing moderate or severe lymphedema. Differences in living characteristics, anxiety, and depression were compared between the no/mild lymphedema group and the moderate/severe lymphedema groups. Preferences for lymphedema management during the pandemic were determined.

Results: Overall, 202 patients were included in this study, and 191 of them reported recurrent lymphedema (prevalence: 94.6%, 95% confidence interval [CI] 90.5% to 97.3%). Among them, 134 and 57 had mild and moderate/severe lymphedema, respectively. In 191 patients, the main symptoms were swelling (140; 69.3%) and pain (56, 27.7%). Multivariable regression showed that older age (odds ratio [OR], 1.06; 95% CI: 1.02-1.10), radical surgery (OR = 4.35, 95% CI: 1.54-12.50), and fully complete radiotherapy (OR = 2.62, 95% CI: 1.17-5.87, p = 0.019) were associated with an elevated risk of moderate/severe lymphedema. The moderate/severe lymphedema group experienced a higher rate of anxiety and depression than the no/mild lymphedema group did. Patients equally preferred treatment in the hospital and self-care at home.

Conclusion: During the COVID-19 pandemic, high prevalence of lymphedema was observed in patients Age, radical surgery and fully completed radiotherapy were associated with increased risk of severer lymphedema. Meanwhile, the patients with severe lymphedema experienced psychological distress. While the Covid-19 pandemic was still raging, continuous efforts should be made to identify patient at risk of lymphedema and distribute feasible guidance and education for self-management in lymphedema.
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http://dx.doi.org/10.1002/cam4.4737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348332PMC
May 2022

Retraction of "Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis".

Open Life Sci 2022 21;17(1):380. Epub 2022 Apr 21.

Department of Anesthesiology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, No. 745 WuLuo Road, Hongshan District, Wuhan City, Hubei Province, China.

[This retracts the article DOI: 10.1515/biol-2021-0072.].
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http://dx.doi.org/10.1515/biol-2022-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026228PMC
April 2022

Global Prevalence and Factors Related to Intimate Partner Violence Amongst People Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression.

Trauma Violence Abuse 2022 May 6:15248380221097436. Epub 2022 May 6.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, 203377National University of Singapore, Singapore.

Reviews of intimate partner violence (IPV) have primarily focused on women and same-sex relationships, but little is known about the global epidemiology of IPV among people living with HIV/AIDS (PLWHA). This review employed meta-analytic approaches to determine the worldwide prevalence and factors related to different forms of IPV among PLWHA. Databases including PubMed, Cochrane review, EMBASE, Scopus, PsycINFO, CINAHL, ProQuest, and registers, were systematically reviewed until November 5, 2021. The meta-analysis was conducted using the package in R software. The Newcastle Ottawa Scale and Cochrane Risk of Bias Tool version 1 were used to assess the study quality and risk of bias, respectively. A total of 49 published articles and 42,280 participants, were included in the meta-analysis. Over their lifetime, four in ten PLWHA have experienced some type of IPV. Over a quarter have experienced physical, emotional, or psychological IPV. One in five PLWHA experienced at least one form of IPV during the recall period of last year, with emotional IPV being the most prevalent. Rates of physical and any types of IPV differed substantially between IPV measurements. IPV rates also varied significantly by the study design, with physical (29%) and sexual (18%) IPV rates being more prevalent in cross-sectional studies. Public health measures are critical for preventing and combating IPV among PLWHA. Additional cross-national research using robust sampling methods is required to obtain more representative samples and thus a more reliable prevalence estimate of IPV prevalence.
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http://dx.doi.org/10.1177/15248380221097436DOI Listing
May 2022
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