Publications by authors named "Jin Liu"

2,111 Publications

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Structural insight into the individual variability architecture of the functional brain connectome.

Neuroimage 2022 Jun 22:119387. Epub 2022 Jun 22.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Chinese Institute for Brain Research, Beijing, 102206, China. Electronic address:

Human cognition and behaviors depend upon the brain's functional connectomes, which vary remarkably across individuals. However, whether and how the functional connectome individual variability architecture is structurally constrained remains largely unknown. Using tractography- and morphometry-based network models, we observed the spatial convergence of structural and functional connectome individual variability, with higher variability in heteromodal association regions and lower variability in primary regions. We demonstrated that functional variability is significantly predicted by a unifying structural variability pattern and that this prediction follows a primary-to-heteromodal hierarchical axis, with higher accuracy in primary regions and lower accuracy in heteromodal regions. We further decomposed group-level connectome variability patterns into individual unique contributions and uncovered the structural-functional correspondence that is associated with individual cognitive traits. These results advance our understanding of the structural basis of individual functional variability and suggest the importance of integrating multimodal connectome signatures for individual differences in cognition and behaviors.
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http://dx.doi.org/10.1016/j.neuroimage.2022.119387DOI Listing
June 2022

The Gut-lung Axis in Severe Acute Panceatitis-associated Lung Injury: the Protection by the Gut Microbiota through Short-chain Fatty Acids.

Pharmacol Res 2022 Jun 22:106321. Epub 2022 Jun 22.

Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116000, P.R. China; Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116000, P.R. China. Electronic address:

The role of gut microbiota in regulating the intestinal homeostasis, as well as the pathogenesis of severe acute pancreatitis-associated lung injury (PALI) is widely recognized. The bioactive functions of metabolites with small molecule weight and the detail molecular mechanisms of PALI mediated by "gut-lung axis" have gradually raised the attentions of researchers. Several studies have proved that short-chain fatty acids (SCFAs) produced by gut microbiome play crucial roles and varied activities in the process of PALI. However, relevant reviews reporting SCFAs in the involvement of PALI is lacking. In this review, we firstly introduced the synthetic and metabolic pathways of SCFAs, as well as the transport and signal transduction routes in brief. Afterwards, we focused on the possible mechanisms and clues of SCFAs to participate in the fight against PALI which referred to the inhibition of pathogen proliferation, anti-inflammatory effects, enhancement of intestinal barrier functions, and the maintenance and regulation of immune homeostasis via pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). In addition, the latest reported pathological and physiological mechanisms of the gut-lung axis involved in PALI were reviewed. Finally, we summarized the potential therapeutic interventions of PALI by targeting SCFAs, including dietary fiber supplementation, direct supplementation of SCFAs/prebiotics/probiotics, and drugs administration, which is expected to provide new sights for clinical use in the future.
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http://dx.doi.org/10.1016/j.phrs.2022.106321DOI Listing
June 2022

circ-RANGAP1/MicroRNA-542-3p/Myosin Regulatory Light Chain Interacting Protein Axis Modulates the Osteosarcoma Cell Progression.

Appl Bionics Biomech 2022 14;2022:4247670. Epub 2022 Jun 14.

Department of Orthopedics, The First Hospital of Lanzhou University, Lanzhou, 730000 Gansu, China.

Objective: This study is aimed at exploring the influence of circular RNA- (circRNA-) RANGAP1 targeting microRNA- (miR-) 542-3p/myosin regulatory light chain interacting protein (MYLIP) on the biological function of osteosarcoma (OS) cells.

Methods: Tumor tissues and normal tissues were collected from OS patients and circ-RANGAP1, miR-542-3p, and MYLIP expression was tested by RT-qPCR. The correlation between the clinicopathology/prognosis of patients with OS and circ-RANGAP1 expression was observed. Human OS cell line MG-63 was screened to determine the influences of circ-RANGAP1 and miR-542-3p on OS cell progression. The targeting relation of circ-RANGAP1, miR-542-3p, and MYLIP was probed.

Results: circ-RANGAP1 expression was elevated in tumor tissues from OS patients, which was correlated to the poor clinicopathology. circ-RANGAP1 expression was augmented in males or patients younger than 20 years old or patients with advanced OS. Higher circ-RANGAP1 expression indicated a poor prognosis in OS patients. After silencing circ-RANGAP1 or elevating miR-542-3p in MG63 cells, cell progression was limited. miR-542-3p downregulation reduced the therapeutic efficacy of silenced circ-RANGAP1. circ-RANGAP1 bound with miR-542-3p to target MYLIP.

Conclusion: Silenced circ-RANGAP1 boosts MYLIP expression via competitive binding of miR-542-3p to facilitate OS cell progression.
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http://dx.doi.org/10.1155/2022/4247670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213143PMC
June 2022

High Birefringence D-Shaped Germanium-Doped Photonic Crystal Fiber Sensor.

Micromachines (Basel) 2022 May 25;13(6). Epub 2022 May 25.

School of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

In this work, a surface plasmon resonance (SPR) sensor based on a D-shaped germanium-doped photonic crystal fiber (PCF) is proposed. The finite element method (FEM) is introduced to analyze the structure parameters, such as germanium-doped concentration, lattice pitch, and air hole size. In addition, the coupling properties and birefringence properties of PCF are also studied. The computer simulation results indicate that two different surface plasmon polariton (SPP) coupling modes are produced on the polished surface, covered with metal film, when the analyte refractive index (RI) is 1.34. Then, with the increase of the RI, the incompleteness of one of the coupling modes will be transformed into the complete coupling. The effect of germanium concentration on the birefringence is also analyzed. It has an optimal wavelength sensitivity of 5600 nm/RIU when the RI is 1.37. This sensor exhibits a maximum birefringence of 1.06 × 10 and a resolution of 1.78 × 10 RIU with high linearity.
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http://dx.doi.org/10.3390/mi13060826DOI Listing
May 2022

Lanthanide (Eu/Tb)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan.

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Institute of Hybrid Materials, National Center of International Joint Research for Hybrid Materials Technology, National Base of International Sci. & Tech. Cooperation on Hybrid Materials, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.

The clinical use of anticancer drugs necessitates new technologies for their safe, sensitive, and selective detection. In this article, lanthanide (Eu and Tb)-loaded γ-cyclodextrin nano-aggregates (ECA and TCA) are reported, which sensitively detects the anticancer drug irinotecan by fluorescence intensity changes. Fluorescent lanthanide (Eu and Tb) complexes exhibit high fluorescence intensity, narrow and distinct emission bands, long fluorescence lifetime, and insensitivity to photobleaching. However, these lanthanide (Eu and Tb) complexes are essentially hydrophobic, toxic, and non-biocompatible. Lanthanide (Eu and Tb) complexes were loaded into naturally hydrophilic γ-cyclodextrin to form fluorescent nano-aggregates. The biological nontoxicity and cytocompatibility of ECA and TCA fluorescent nanoparticles were demonstrated by cytotoxicity experiments. The ECA and TCA fluorescence nanosensors can detect irinotecan selectively and sensitively through the change of fluorescence intensity, with detection limits of 6.80 μM and 2.89 μM, respectively. ECA can safely detect irinotecan in the cellular environment, while TCA can detect irinotecan intracellularly and is suitable for cell labeling.
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http://dx.doi.org/10.3390/ijms23126597DOI Listing
June 2022

NH Plasma Functionalization of UiO-66-NH for Highly Enhanced Selective Fluorescence Detection of U(VI) in Water.

Anal Chem 2022 Jun 23. Epub 2022 Jun 23.

Department of Chemical Engineering, Monash University, Clayton, Victoria 3800, Australia.

Radioactive U(VI) in nuclear wastewater is a global environmental pollutant that poses a great threat to human health. Therefore, it is of great significance to develop a U(VI) sensor with desirable sensitivity and selectivity. Inspired by electron-donating group modification for enhancement of binding affinity toward U(VI), we report an amine group functionalization of UiO-66-NH, using a low-cost, environmentally friendly, and low-temperature NH plasma technique as a fluorescence switching nanoprobe for highly sensitive and selective detection of U(VI). The resulting amine-functionalized UiO-66-NH ([email protected]) shows dramatically enhanced fluorescence emission and selective sensitivity for U(VI) on the basis of the quenching effect. The quenching efficiency increases from 58 to 80% with the same U(VI) concentration (17.63 μM) after NH plasma functionalization. As a result, the [email protected] has the best (1.81 × 10 M, 298 K) and among the lowest LODs (0.08 μM, 19.04 ppb) compared with those reported in the literature. Intraday and interday precision and application in real environment experiments indicate stable and accurate U(VI) detection performance. Fluorescence lifetime and temperature-dependent detection experiments reveal that the quenching mechanism belongs to the static quenching interaction. The highly selective fluorescence detection is attributed to the selective binding of U(VI) by the rich functionalized amine groups of [email protected] This work provides an efficient fluorescence probe for highly sensitive U(VI) detection in water, and a new strategy of tailored plasma functionalization for developing a practical MOF sensor platform for enhanced fluorescence emission, sensitivity, and selectivity for detecting trace amounts of radioactive species in the environment.
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http://dx.doi.org/10.1021/acs.analchem.2c01138DOI Listing
June 2022

Automatic Grading of Disc Herniation, Central Canal Stenosis and Nerve Roots Compression in Lumbar Magnetic Resonance Image Diagnosis.

Front Endocrinol (Lausanne) 2022 6;13:890371. Epub 2022 Jun 6.

Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Aim: Accurate severity grading of lumbar spine disease by magnetic resonance images (MRIs) plays an important role in selecting appropriate treatment for the disease. However, interpreting these complex MRIs is a repetitive and time-consuming workload for clinicians, especially radiologists. Here, we aim to develop a multi-task classification model based on artificial intelligence for automated grading of lumbar disc herniation (LDH), lumbar central canal stenosis (LCCS) and lumbar nerve roots compression (LNRC) at lumbar axial MRIs.

Methods: Total 15254 lumbar axial T2W MRIs as the internal dataset obtained from the Fifth Affiliated Hospital of Sun Yat-sen University from January 2015 to May 2019 and 1273 axial T2W MRIs as the external test dataset obtained from the Third Affiliated Hospital of Southern Medical University from June 2016 to December 2017 were analyzed in this retrospective study. Two clinicians annotated and graded all MRIs using the three international classification systems. In agreement, these results served as the reference standard; In disagreement, outcomes were adjudicated by an expert surgeon to establish the reference standard. The internal dataset was randomly split into an internal training set (70%), validation set (15%) and test set (15%). The multi-task classification model based on ResNet-50 consists of a backbone network for feature extraction and three fully-connected (FC) networks for classification and performs the classification tasks of LDH, LCCS, and LNRC at lumbar MRIs. Precision, accuracy, sensitivity, specificity, F1 scores, confusion matrices, receiver-operating characteristics and interrater agreement (Gwet k) were utilized to assess the model's performance on the internal test dataset and external test datasets.

Results: A total of 1115 patients, including 1015 patients from the internal dataset and 100 patients from the external test dataset [mean age, 49 years ± 15 (standard deviation); 543 women], were evaluated in this study. The overall accuracies of grading for LDH, LCCS and LNRC were 84.17% (74.16%), 86.99% (79.65%) and 81.21% (74.16%) respectively on the internal (external) test dataset. Internal and external testing of three spinal diseases showed substantial to the almost perfect agreement (k, 0.67 - 0.85) for the multi-task classification model.

Conclusion: The multi-task classification model has achieved promising performance in the automated grading of LDH, LCCS and LNRC at lumbar axial T2W MRIs.
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http://dx.doi.org/10.3389/fendo.2022.890371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207332PMC
June 2022

Risk Factors for Diabetic Peripheral Neuropathy, Peripheral Artery Disease, and Foot Deformity Among the Population With Diabetes in Beijing, China: A Multicenter, Cross-Sectional Study.

Front Endocrinol (Lausanne) 2022 6;13:824215. Epub 2022 Jun 6.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Diabetic peripheral neuropathy (DPN), peripheral artery disease (PAD), and foot deformity are the most common causes of diabetic foot, which can considerably worsen the patient's quality of life. In this study, we aimed to investigate the prevalence and risk factors associated with DPN, PAD, and foot deformity among patients with diabetes living in Beijing, China. In total, 3,898 diabetes patients from 11 hospitals in Beijing were evaluated using questionnaires and physical examinations, and 3,758 patients were included in the analysis. We compared the demographic, clinical, biological characteristics, and comorbidities of patients with and without DPN, PAD, or foot deformity, and used binary logistic regression analysis to identify potential factors associated with these outcomes. Overall, 882 patients (23.5%) had DPN, 437 patients (11.6%) had PAD, and 1,117 patients (29.7%) had foot deformities, including callus. The risk factors for DPN included: age ≥40 years, a ≥10+year duration of diabetes, a body mass index of <18.5 kg/m or ≥24 kg/m, a systolic blood pressure (SBP) of ≥140 mm Hg, a hemoglobin A (HbA) level of ≥7%, chronic kidney disease, and cerebrovascular disease. The risk factors for PAD included: a 15+ year diabetes duration, a body mass index of <18.5 kg/m, a SBP of ≥140 mm Hg, a HbA level of ≥7%, chronic kidney disease, coronary heart disease, and cerebrovascular disease. The risk factors for skeletal foot deformities included: women, age ≥40 years, a SBP ≥140 mm Hg, and hyperlipidemia. The risk factors for callus formation included: women, a SBP ≥140 mm Hg, and hyperlipidemia. In conclusion, the prevalence of foot deformities was higher than DPN and PAD in patients with diabetes. Managing the risk factors for DPN, PAD, and foot deformity is important for reducing the risk of diabetic foot.
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http://dx.doi.org/10.3389/fendo.2022.824215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207340PMC
June 2022

Nomograms for Predicting Coexisting Cardiovascular Disease and Prognosis in Chronic Obstructive Pulmonary Disease: A Study Based on NHANES Data.

Can Respir J 2022 9;2022:5618376. Epub 2022 Jun 9.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an 710061, Shaanxi, China.

Background: Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Progression is further exacerbated by the coexistence of cardiovascular disease (CVD). We aim to construct a diagnostic nomogram for predicting the risk of coexisting CVD and a prognostic nomogram for predicting long-term survival in COPD.

Methods: The 540 eligible participants selected from the NHANES 2005-2010 were included in this study. Logistic regression analysis was used to construct a diagnostic nomogram for the diagnosis of coexisting CVD in COPD. Cox regression analyses were used to construct a prognostic nomogram for COPD. A risk stratification system was developed based on the total score generated from the prognostic nomogram. We used C-index and ROC curves to evaluate the discriminant ability of the newly built nomograms. The models were also validated utilizing calibration curves. Survival curves were made using the Kaplan-Meier method and compared by the Log-rank test.

Results: Logistic regression analysis showed that gender, age, neutrophil, RDW, LDH, and HbA1c were independent predictors of coexisting CVD and were included in the diagnostic model. Cox regression analysis indicated that CVD, gender, age, BMI, RDW, albumin, LDH, creatinine, and NLR were independent predictors of COPD prognosis and were incorporated into the prognostic model. The C-index and ROC curves revealed the good discrimination abilities of the models. And the calibration curves implied that the predicted values by the nomograms were in good agreement with the actual observed values. In addition, we found that coexisting with CVD had a worse prognosis compared to those without CVD, and the prognosis of the low-risk group was better than that of the high-risk group in COPD.

Conclusions: The nomograms we developed can help clinicians and patients to identify COPD coexisting CVD early and predict the 5-year and 10-year survival rates of COPD patients, which has some clinical practical values.
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http://dx.doi.org/10.1155/2022/5618376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203208PMC
June 2022

Signatures of Thalamocortical Alpha Oscillations and Synchronization With Increased Anesthetic Depths Under Isoflurane.

Front Pharmacol 2022 3;13:887981. Epub 2022 Jun 3.

Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.

Electroencephalography (EEG) recordings under propofol exhibit an increase in slow and alpha oscillation power and dose-dependent phase-amplitude coupling (PAC), which underlie GABA potentiation and the central role of thalamocortical entrainment. However, the exact EEG signatures elicited by volatile anesthetics and the possible neurophysiological mechanisms remain unclear. Cortical EEG signals and thalamic local field potential (LFP) were recorded in a mouse model to detect EEG signatures induced by 0.9%, 1.5%, and 2.0% isoflurane. Then, the power of the EEG spectrum, thalamocortical coherence, and slow-alpha phase-amplitude coupling were analyzed. A computational model based on the thalamic network was used to determine the primary neurophysiological mechanisms of alpha spiking of thalamocortical neurons under isoflurane anesthesia. Isoflurane at 0.9% (light anesthesia) increased the power of slow and delta oscillations both in cortical EEG and in thalamic LFP. Isoflurane at 1.5% (surgery anesthesia) increased the power of alpha oscillations both in cortical EEG and in thalamic LFP. Isoflurane at 2% (deep anesthesia) further increased the power of cortical alpha oscillations, while thalamic alpha oscillations were unchanged. Thalamocortical coherence of alpha oscillation only exhibited a significant increase under 1.5% isoflurane. Isoflurane-induced PAC modulation remained unchanged throughout under various concentrations of isoflurane. By adjusting the parameters in the computational model, isoflurane-induced alpha spiking in thalamocortical neurons was simulated, which revealed the potential molecular targets and the thalamic network involved in isoflurane-induced alpha spiking in thalamocortical neurons. The EEG changes in the cortical alpha oscillation, thalamocortical coherence, and slow-alpha PAC may provide neurophysiological signatures for monitoring isoflurane anesthesia at various depths.
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http://dx.doi.org/10.3389/fphar.2022.887981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204038PMC
June 2022

[Clinical observation on different frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris].

Zhongguo Zhen Jiu 2022 Jun;42(6):629-33

College of Acupuncture-Moxibustion and Tuina, Hebei University of CM, Shijiazhuang 050200, China; International Joint Research Center for Advantageous Diseases of Acupuncture and Moxibustion in Hebei Province, Shijiazhuang 050200.

Objective: To observe the clinical efficacy of different treatment frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris.

Methods: A total of 90 patients with acne vulgaris were randomized into a treatment group 1 (30 cases, 2 cases dropped off), a treatment group 2 (30 cases, 4 cases dropped off) and a treatment group 3 (30 cases, 5 cases dropped off). Combination therapy of auricular bloodletting and auricular point sticking at Fei (CO), Shenmen (TF), Neifenmi (CO) and Shenshangxian (TGp) were given once a week, twice a week and 3 times a week in the treatment group 1, the treatment group 2 and the treatment group 3 respectively, 4 weeks were as one course and totally 3 courses were required in the 3 groups. Before treatment and after 1, 2, 3 courses of treatment, the scores of global acne grading system (GAGS), skin lesion and quality of life-acne (QoL-Acne) were observed, the clinical efficacy was evaluated after 3 courses of treatment and the recurrence rate was evaluated in follow-up of 1 month after treatment in the 3 groups.

Results: Compared before treatment, the scores of GAGS and skin lesion were decreased at each time point in the 3 groups (<0.05), the QoL-Acne scores were increased after 1 course of treatment in the treatment group 3 and after 2, 3 courses of treatment in the 3 groups (<0.05). There were no statistical differences in scores of GAGS, skin lesion and QoL-Acne among the 3 groups (>0.05). There were no statistical differences in effective rate and recurrence rate among the 3 groups (>0.05).

Conclusion: Different frequency of auricular bloodletting combined with auricular point sticking have similar efficacy in treating acne vulgaris, all can improve the skin lesion and quality of life in patients with acne vulgaris, and have a cumulative effect and good long-term curative effect.
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http://dx.doi.org/10.13703/j.0255-2930.20210519-k0006DOI Listing
June 2022

Effectiveness of the Sanyin Formula Plus Chemotherapy on Survival in Women With Triple-Negative Breast Cancer: A Randomized Controlled Trial.

Front Oncol 2022 26;12:850155. Epub 2022 May 26.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Purpose: To evaluate the efficacy of the Sanyin formula (SYF) plus conventional standard chemotherapy in operable triple-negative breast cancer (TNBC) patients, a randomized controlled trial was implemented at 5 hospitals and cancer centers in China between May 23, 2016, and October 31, 2019.

Materials And Methods: Female patients aged 18 to 80 years with operable TNBC after definitive surgery were screened and enrolled. The exclusion criteria included metastatic disease, other tumors, or locally advanced disease. Patients were randomly divided into groups SYF plus conventional standard chemotherapy and placebo plus conventional standard chemotherapy at a ratio of 1:1. The primary endpoint of the investigation was disease-free survival (DFS), and secondary endpoints included overall survival (OS) and toxicity.

Results: A total of 252 operable female TNBC patients were randomized to receive SYF plus conventional standard chemotherapy (N = 127) or a placebo plus conventional standard chemotherapy (N = 125). At a median follow-up of 51 months, 5-year DFS time was longer in those assigned to SYF plus conventional standard chemotherapy compared with placebo plus conventional standard chemotherapy (94.2%vs 85.5%, hazard ratio [HR] = 0.40; 95%CI, 0.17-0.97; = 0.034). The absolute benefit for 5-year DFS was 8.7% in the SYF plus conventional standard chemotherapy group. No statistically significant difference was observed in OS between the two groups ( = 0.23). Patients with negative node status benefited more from SYF plus conventional standard chemotherapy treatment (HR = 0.21, -interaction = 0.013) in accordance with the exploratory subgroup analyses of DFS.

Conclusions: The results of the present study suggest that the traditional Chinese medicine SYF plus conventional chemotherapy regimens is an effective alternative adjuvant chemotherapy strategy for female operable TNBC patients.

Clinical Trial Registration: https://www.chictr.org.cn/searchproj.aspx, identifier ChiCTR-IPR-16008590.
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http://dx.doi.org/10.3389/fonc.2022.850155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197261PMC
May 2022

Research on Neck Response of Elderly Drivers in Rear Collision.

Biomed Res Int 2022 7;2022:5239515. Epub 2022 Jun 7.

Key Laboratory and Lightweight and Reliability Technology for Engineering Vehicle, Education Department of Hunan Province, Changsha University of Science and Technology, Changsha 410004, China.

In order to study the neck response of elderly drivers in rear collision, a finite element model for elderly neck was built. By comparing the cadaver experiment data in the literature, the simulation reliability of the head and neck model of the elderly under dynamic load was verified. Through the C-NCAP rear-end collision test on the elderly model, the study showed that the neck of the elderly driver had good dynamic response characteristics. The verified finite element model was used to analyze the head and neck collision response and injury risk of the elderly under different distances between the head and the headrest (vertical distance and horizontal distance). By analyzing the head and neck injuries of occupants at different distances, it was found that when the horizontal distance was 50 mm, and the vertical distance was between +10 and ~+20 mm, the headrest could play the best role in protecting the neck of the elderly driver and could reduce the degree of injury of the elderly driver in the process of rear collision.
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http://dx.doi.org/10.1155/2022/5239515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197624PMC
June 2022

Reversible color modulation of luminescent conjugated polymers based on a chemical redox mechanism and applications in rewritable paper and multiple information encryption.

Mater Horiz 2022 Jun 14. Epub 2022 Jun 14.

Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, P. R. China.

Reversible color modulation plays a key role in the field of information recording and encryption, but for the common colorful conjugated polymer materials, currently a convenient method to achieve their reversible color modulation is still lacking. Herein, six luminescent conjugated polymers P1 to P6 were successfully designed and synthesized, all of which could realize reversible color modulation through a similar reversible chemical redox behavior accompanied by reversible color and fluorescence changes. The same absorption spectral changes as those under electrochemical redox conditions strongly confirmed that these polymers underwent reversible redox reactions in the Fe and HO system, which happened spontaneously according to the theoretical analysis of the reaction thermodynamics. Based on the reversible color modulation in the Fe and HO system, polymers P1, P2 and P3, with different colors (yellow, orange and red) and fluorescence emissions, were successfully applied as rewritable paper with multi-color and multi-fluorescence printing as well as long-term recording capabilities. Meanwhile, polymers P1, P4, P5 and P6, which showed similar green fluorescence and yellow color but different oxidation potentials, were also introduced to accomplish multiple encryption and decryption of information, based on the step-by-step selective oxidation of the four polymers by adjusting the concentration of Fe.
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http://dx.doi.org/10.1039/d2mh00566bDOI Listing
June 2022

Transarterial Chemoembolization Combined with Lenvatinib versus Transarterial Chemoembolization Combined with Sorafenib for Unresectable Hepatocellular Carcinoma: A Comparative Retrospective Study.

Hepatol Res 2022 Jun 13. Epub 2022 Jun 13.

Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.

Aim: Tyrosine kinase inhibitors (TKIs) target transarterial chemoembolization (TACE)-mediated vascular endothelial growth factor to inhibit tumor revascularization and to slow tumor progression. The present study aimed to compare the clinical outcomes of TACE combined with lenvatinib (TACE-lenvatinib) and TACE combined with sorafenib (TACE-sorafenib) in patients with unresectable hepatocellular carcinoma (HCC).

Methods: The clinical data of patients diagnosed with unresectable HCC who received TACE-lenvatinib or TACE-sorafenib between January 2018 and April 2021 were retrospectively reviewed. The tumor response, progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were evaluated and compared between the two groups.

Results: A total of 112 patients were enrolled and classified into the TACE-lenvatinib group (n = 53) and the TACE-sorafenib group (n = 59). The objective response rates (ORRs) of patients in the TACE-lenvatinib and TACE-sorafenib groups were 54.7% and 44.1%, respectively (P = 0.260), and the disease control rates (DCRs) were 81.1% and 61.0% (P = 0.020). The median PFS time was significantly longer in the TACE-lenvatinib group than in the TACE-sorafenib group (10.7 vs. 6.0 months; P = 0.002). The median OS time between the TACE-lenvatinib and TACE-sorafenib groups also showed a significant difference (30.5 vs. 20.5 months, P = 0.018). All treatment-related AEs and grade 3/4 AEs were comparable between the two groups (P > 0.05).

Conclusion: Compared to TACE-sorafenib, TACE-lenvatinib was associated with better DCR, PFS and OS outcomes in patients with unresectable HCC. In subgroups of BCLC B stage or TACE-refractory patients, TACE-lenvatinib also showed a trend of superiority. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1111/hepr.13801DOI Listing
June 2022

Ischemic limb preconditioning-induced anti-arrhythmic effect in reperfusion-induced myocardial injury: is it mediated by the RISK or SAFE pathway?

Pflugers Arch 2022 Jun 13. Epub 2022 Jun 13.

Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

The mechanism for limb ischemic precondition (RLIPC)-induced suppression of reperfusion arrhythmia remains unknown. The purpose of this study was to examine the roles of the pro-survival reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways in this RLIPC-mediated antiarrhythmic activity. Male Sprague Dawley rats were assigned to sham-operated, control, or RLIPC groups. All rats except for the sham rats had 5 min of left main coronary artery occlusion with another 20 min of reperfusion. RLIPC was initiated by four cycles of limb ischemia (5 min) and reperfusion (5 min) on the bilateral femoral arteries. Hearts in every group were taken for protein phosphorylation analysis. RLIPC ameliorated reperfusion-induced arrhythmogenesis and reduced the incidence of sudden cardiac death during the entire 20-min reperfusion period (66.7% of control rats had SCD vs. only 16.7% of RLIPC-treated rats). RLIPC enhances ventricular ERK1/2 phosphorylation after reperfusion. RLIPC-induced antiarrhythmic action and ERK1/2 phosphorylation are abolished in the presence of the ERK1/2 inhibitor U0126. Limb ischemic preconditioning protects the heart against myocardial reperfusion injury-induced lethal arrhythmia. These beneficial effects may involve the activation of ERK1/2 in the RISK signaling pathway.
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http://dx.doi.org/10.1007/s00424-022-02716-5DOI Listing
June 2022

PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT.

Biomed Pharmacother 2022 Aug 8;152:113233. Epub 2022 Jun 8.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. Electronic address:

Vascular remodeling is a significant feature of pulmonary artery hypertension (PAH), and is characterized by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Telomerase reverse transcriptase (TERT), as a determining factor for controlling telomerase activity, has been proven to be associated with cell proliferation. This study aims to explore whether TERT mediates the proliferation and migration of PASMCs and the underlying molecular mechanism. Primary PASMCs from Sprague-Dawley (SD) rats were used in this experiment. Cell proliferation and migration were evaluated by Cell Counting Kit-8, EdU incorporation assay and transwell assay, respectively. Telomerase activity was assessed with a rat TE ELISA kit. Small interfering RNA (siRNA) transfection was conducted to silence c-MYC expression. The protein levels of p-Akt, c-MYC, PPARγ and TERT were determined through western blotting. Our work demonstrates that PDGF upregulated TERT expression and telomerase activation by activating Akt and upregulating of c-MYC in PASMCs. Inhibition of Akt with LY294002, knockdown of c-MYC by siRNA or suppression of telomerase activity with BIBR1532 repressed PDGF-induced PASMC proliferation and migration. Furthermore, activation of peroxisome proliferator-activated receptor γ (PPARγ) with pioglitazone suppressed PDGF-induced TERT expression and telomerase activation, leading to inhibition of PASMC proliferation and migration.
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http://dx.doi.org/10.1016/j.biopha.2022.113233DOI Listing
August 2022

Effects of Different Anesthetics on Perioperative Organ Protection and Postoperative Cognitive Function in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass.

Comput Intell Neurosci 2022 29;2022:8994946. Epub 2022 May 29.

Department of Vascular Surgery, People's Hospital of Wuhan University, Wuhuna, China.

In this paper, we have carried out an experimental study to investigate the effects of different anesthetics on perioperative organ protection and postoperative cognitive function in patients undergoing cardiac valve replacement with cardiopulmonary bypass. To realize this idea, a total of 90 patients with single valve replacement under general anesthesia and hypothermic cardiopulmonary bypass from January 2020 to October 2021 were enrolled. These patients were assigned into three groups, with 30 cases in each group by the digital table method. Group A was anesthetized with sufentanil combined with dexmedetomidine. Group B was anesthetized with sufentanil combined with etomidate. Group C was anesthetized with sufentanil combined with propofol. Perioperative organ protection and postoperative cognitive function of the three groups were compared. At time point, there was no significant difference in blood WBC, blood , and CRP among groups A, B, and C ( > 0.05); At and time points, the indexes of blood WBC, blood , and CRP in groups A, B, and C were higher compared to the time point. At and time points, the indexes of blood WBC, blood and CRP in group A were significantly lower compared to group B and group C. Before treatment, there was no significant difference in ALT and AST among groups A, B, and C ( > 0.05). After treatment, the indexes of ALT and AST in group A were significantly lower compared to group B and group C at and time points ( < 0.05). Before treatment, there was no significant difference in urea and creatinine among groups A, B, and C ( > 0.05). After treatment, the urea and creatinine indexes of group A were significantly lower compared to group B and group C at and time points ( < 0.05). Before treatment, there was no significant difference in CK-MB and CTnl among groups A, B, and C ( > 0.05); After treatment, the indexes of CK-MB and CTnl in group A were significantly lower compared to group B and group C at and time points (  < 0.05). Before treatment, there was no significant difference in MOCA scores among groups A, B, and C ( > 0.05). After treatment, the MOCA scores of group A were significantly higher compared to group B and group C at and time points (  < 0.05). Sufentanil combined with dexmedetomidine for heart valve replacement under cardiopulmonary bypass can reduce the dosage of anesthetics during the operation and have a certain perioperative protective effect on important organs such as the heart, lung, liver, and kidney, which may be related to reducing intraoperative hemodynamic fluctuations and inhibiting inflammatory stress response.
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http://dx.doi.org/10.1155/2022/8994946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168101PMC
June 2022

An activatable near-infrared hemicyanine-based probe for selective detection and imaging of Hg in living cells and animals.

Analyst 2022 Jun 7. Epub 2022 Jun 7.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.

Fluorescence imaging in the near-infrared (NIR) window has great potential for clinical diagnosis and treatment because of its deep penetration and high contrast. Here, a NIR hemicyanine-based probe (CyP) was synthesized for selective detection and imaging of Hg in living cells and animals. Using the rigid xanthene structure as the electron donor, trimethylindolenine as the electron acceptor and diphenylphosphinothioic chloride as the recognition element, the probe CyP could specifically respond to Hg and transform into an activated donor-π-acceptor (D-π-A) motif with a NIR emission maximum at 710 nm. Cell and animal imaging experiments showed that the probe CyP could be activated by Hg and had good concentration dependence in imaging. Meanwhile, animal imaging experiments showed that the activated CyP probe exhibited a higher tissue penetration depth and spatiotemporal resolution. Thus, the probe CyP could be a useful tool for monitoring and visually evaluating Hg in living systems.
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http://dx.doi.org/10.1039/d2an00125jDOI Listing
June 2022

The prevalence of oropharyngeal dysphagia in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Expert Rev Respir Med 2022 Jun 17:1-8. Epub 2022 Jun 17.

School of Nursing, Lanzhou University, Lanzhou, Gansu, China.

Background: Oropharyngeal dysphagia (OD) in chronic obstructive pulmonary disease (COPD) patients seriously influence the long-term prognosis of COPD patients. The aim of this study was to assess the prevalence and risk factors of OD in patients with COPD through a systematic review and meta-analysis of observational studies.

Methods: We identified all observational studies on the prevalence of OD in COPD patients by searching PubMed, Embase, the Cochrane Library, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China National Knowledge Infrastructure (CNKI), the China Biomedical Literature Service System (CBM), the Wanfang Database, and the WeiPu (VIP) databases from database establishment to 1 December 2020.

Results:     Results of the meta-analysis showed that the prevalence of OD in COPD patients was 32.7% (95%CI=30.1, 35.4, I2=91.5%). Dyspnea, gastroesophageal reflux disease(GERD), xerostomia, sputum bacteria, poor physical capacity, poor quality of life, and high CRP level are the risk factors for OD in COPD patients.

Conclusion: : The prevalence of OD in COPD patients is high. There were some differences in OD among COPD patients with different sex, ages, continents, evaluation methods, patient source and COPD exacerbation.
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http://dx.doi.org/10.1080/17476348.2022.2086123DOI Listing
June 2022

Matrix Metalloproteinase-2-Responsive Surface-Changeable Liposomes Decorated by Multifunctional Peptides to Overcome the Drug Resistance of Triple-Negative Breast Cancer through Enhanced Targeting and Penetrability.

ACS Biomater Sci Eng 2022 Jun 6. Epub 2022 Jun 6.

Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, National clinical research center for geriatrics, Translational Neuroscience center, Department of Anesthesiology, The Research Units of West China, Chinese Academy of Medical Science, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

Although nanomedicine has demonstrated great potential for combating drug resistance, its suboptimal recognition of malignant cells and limited transport across multiple biological obstacles seriously impede the efficacious accumulation of drugs in tumor lesions, which strikingly limits its application in the clinical therapy of drug-resistant triple-negative breast cancer (TNBC). Hence, a surface-variable drug delivery vehicle based on the modification of liposomes with a multifunctional peptide (named EMC) was fabricated in this work and used for encapsulating doxorubicin and the p-glycoprotein inhibitor tariquidar. This EMC peptide contains an EGFR-targeting bullet that was screened from a "one-bead one-compound" combinatorial library, an MMP-2-cleaved substrate, and a cell-penetrating segment. The EGFR-targeting sequence has been validated to possess excellent specificity and affinity for EGFR at both the cellular and molecular levels and could be unloaded from the EMC peptide by MMP-2 in the tumor microenvironment. This doxorubicin/tariquidar-coloaded and peptide-functionalized liposome (DT-pLip) exhibited superior efficacy in tumor growth inhibition to drug-resistant TNBC both and through EGFR targeting, osmotic enhancement in response to MMP-2, controllable release, and inhibited efflux. Consequently, our systematic studies indicated the potential of this liposome-based nanoplatform in the therapy of drug-resistant TNBC through targeting effects and tumor microenvironment-triggered penetration enhancement.
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http://dx.doi.org/10.1021/acsbiomaterials.2c00295DOI Listing
June 2022

The Quality of Life for Children with Autism Spectrum Disorder Scale: Factor Analysis, MIMIC Modeling, and Cut-Off Score Analysis.

J Autism Dev Disord 2022 Jun 3. Epub 2022 Jun 3.

Old Dominion University, 4501 Hampton Blvd., Child Study Center 124, Norfolk, VA, 23529, USA.

Our purpose in this study was to further examine the psychometric properties of the Quality of Life for Children with Autism Spectrum Disorder (QOLASD-C) scale. We first investigated the factor structure and the internal consistency of the scale. The bifactor model showed good fit and strong reliability. Second, we used multiple-indicators multiple-causes (MIMIC) modeling to examine the associations between demographic variables and the QOLASD-C dimensions. Results showed differences on overall QOL based on age, race/ethnicity, and autism spectrum disorder severity, but no relationships with gender. All demographic variables were associated with one or all three subscales (i.e., interpersonal relationships, self-determination, emotional well-being) of the QOLASD-C. Third, an optimal cut-off score of 37 was identified. Implications for research and practice are discussed.
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http://dx.doi.org/10.1007/s10803-022-05610-2DOI Listing
June 2022

Sparse group selection and analysis of function-related residue for protein-state recognition.

J Comput Chem 2022 Jul 3;43(20):1342-1354. Epub 2022 Jun 3.

Department of Industrial, Manufacturing and Systems Engineering, University of Texas at Arlington, Arlington, Texas, USA.

Machine learning methods have helped to advance wide range of scientific and technological field in recent years, including computational chemistry. As the chemical systems could become complex with high dimension, feature selection could be critical but challenging to develop reliable machine learning based prediction models, especially for proteins as bio-macromolecules. In this study, we applied sparse group lasso (SGL) method as a general feature selection method to develop classification model for an allosteric protein in different functional states. This results into a much improved model with comparable accuracy (Acc) and only 28 selected features comparing to 289 selected features from a previous study. The Acc achieves 91.50% with 1936 selected feature, which is far higher than that of baseline methods. In addition, grouping protein amino acids into secondary structures provides additional interpretability of the selected features. The selected features are verified as associated with key allosteric residues through comparison with both experimental and computational works about the model protein, and demonstrate the effectiveness and necessity of applying rigorous feature selection and evaluation methods on complex chemical systems.
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http://dx.doi.org/10.1002/jcc.26937DOI Listing
July 2022

Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial.

Basic Clin Pharmacol Toxicol 2022 Jun 2. Epub 2022 Jun 2.

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi-centre, non-inferiority trial was conducted to compare the deep sedation properties of ciprofol and propofol with a non-inferiority margin of 8% in patients undergoing gastroscopy and colonoscopy. In total, 289 patients were randomly allocated for surgery (259 colonoscopy and 30 gastroscopy) at a 1:1 ratio to be given intravenous injections of ciprofol (0.4 mg/kg) or propofol (1.5 mg/kg). The primary outcome was the success rate of colonoscopy defined as colonoscopy completion with no need for an alternative sedative or >5 ciprofol or propofol top up doses within any 15-min time period. The success rate of colonoscopy was 100% in the ciprofol group vs. 99.2% in the propofol group (mean difference 0.8%, 95% CI: -2.2% to 4.2%). Except for the gastrointestinal lesions found during the gastroscopy and colonoscopy procedures, the occurrence rates of adverse drug reactions in the ciprofol and propofol groups were 31.3% and 62.8%, respectively (P < 0.001). Pain on injection was less common in the ciprofol group (4.9% vs. 52.4%, P < 0.001). The outcomes demonstrated that ciprofol was non-inferior to propofol with regard to successful sedation for gastroscopy or colonoscopy procedures and no obvious important adverse events occurred.
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http://dx.doi.org/10.1111/bcpt.13761DOI Listing
June 2022

Drug discovery of sclerostin inhibitors.

Acta Pharm Sin B 2022 May 21;12(5):2150-2170. Epub 2022 Jan 21.

Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tsai, Hong Kong 999077, China.

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA, the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis; however, it conferred high cardiovascular risk in clinical trials. Furthermore, romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy.
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http://dx.doi.org/10.1016/j.apsb.2022.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136615PMC
May 2022

E161111 is an ultra-short-acting etomidate analogue with stable haemodynamics that elicits only slight adrenocortical suppression in rats.

PeerJ 2022 24;10:e13492. Epub 2022 May 24.

Laboratory of Anaesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Purpose: We report on a novel ultra-short-acting etomidate analogue, E161111, which has the same primary metabolite as etomidate.

Methods: The metabolic rate of E161111 was determined in rat plasma and liver homogenate. Rats were infused for 30 or 60 min to maintain light sedation at Richmond Agitation-Sedation Scale (RASS) for -2 to 0 score. Mean arterial pressure (MAP) was monitored during 30 min infusion. The serum corticosterone was determined during and 3 h after infusion as a measure of adrenocortical function.

Results: E161111 was not detected in rat plasma at 1 min (t = 6.69 ± 0.07 s) and in rat liver homogenates at 5 min (t = 10.20 ± 3.76 s); its main metabolic product was etomidate acid. The recovery time from loss of righting reflex (LORR) was 4.3 ± 1.5 min after 1-h infusion of E161111. During 30 min infusion, E161111 did not cause MAP changes. The stimulated serum corticosterone levels after 1-h infusion of E161111 were significantly higher than that after 1-h infusion of etomidate at all time points tested for the 3 h study.

Conclusions: E161111 was metabolised rapidly, the metabolites were same as etomidate, and the recovery time after 1-h infusion was short. It elicited haemodynamic stability and milder suppression of corticosterone than that elicited by etomidate.
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http://dx.doi.org/10.7717/peerj.13492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138173PMC
May 2022

Low Psoas-Muscle index is associated with decreased survival in hepatocellular carcinoma treated with transarterial chemoembolization.

Ann Med 2022 12;54(1):1562-1569

Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Purpose: Skeletal muscle index (SMI) is a promising predictor of clinical outcomes in patients with malignant diseases. As a simpler surrogate of sarcopenia-psoas muscle index (PMI), its predict value for overall survival (OS) after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) has not been reported. To determine if changes in the PMI predicted OS in individuals with HCC treated with TACE.

Patients And Methods: A retrospective analysis was performed in HCC patients treated with TACE between January 2018 and March 2019. The survival curve according to PMI was estimated by the Kaplan-Meier method and then compared by the log-rank test. Cox proportional hazards models were conducted to identify the prognostic factors for OS. Furthermore, the predictive abilities of PMI and SMI were compared by using Harrell's concordance index (C-index).

Results: Two hundred and twenty-eight patients (175 men, mean age 59 ± 11 years) were analysed. The OS was less in patients with low PMI than those with high PMI (median OS: 16.9 vs. 38.5 months,  < .001). Multivariate analysis found that either PMI (hazard ratio [HR] = 0.64; 95% confidence interval [CI], 0.45-0.91;  < .001) or SMI (HR = 0.51; 95% CI, 0.36-0.72;  < .001) was significantly associated with OS. In the multivariate analysis, the C-index for PMI was 0.78 and 0.79 for SMI ( = .985).

Conclusion: PMI is a simple tool to predict OS in HCC patients treated with TACE. The predictive ability of PMI is comparable to that of SMI. Key messagesLow psoas-muscle index is associated with decreased overall survival in hepatocellular carcinoma treated with transarterial chemoembolization (TACE).Psoas-muscle index has advantages of being faster and easier to acquire, which thus makes it more likely to achieve widespread clinical application.
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http://dx.doi.org/10.1080/07853890.2022.2081872DOI Listing
December 2022

Room-Temperature Strong Coupling Between a Single Quantum Dot and a Single Plasmonic Nanoparticle.

Nano Lett 2022 Jun 31;22(12):4686-4693. Epub 2022 May 31.

State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics, Sun Yat-sen University, Guangzhou 510275, China.

A single quantum dot (QD) strongly coupled with a plasmonic nanoparticle yields a promising qubit for scalable solid-state quantum information processing at room temperature. However, realizing such a strong coupling remains challenging due to the difficulty of spatial overlap of the QD excitons with the plasmonic electric fields (EFs). Here, by using a transmission electron microscope we demonstrate for the first time that this overlap can be realized by integrating a deterministic single QD with a single Au nanorod. When a wedge nanogap cavity consisting of them and the substrate is constructed, the plasmonic EFs can be more effectively "dragged" and highly confined in the QD's nanoshell where the excitons mainly reside. With these advantages, we observed the largest spectral Rabi splitting (reported so far) of ∼234 meV for a single QD strong coupling with plasmons. Our work opens a pathway to the massive construction of room-temperature strong coupling solid qubits.
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http://dx.doi.org/10.1021/acs.nanolett.2c00606DOI Listing
June 2022

Organic-inorganic calcium lignosulfonate compounds for soil acidity amelioration.

Environ Sci Pollut Res Int 2022 May 28. Epub 2022 May 28.

Beijing Key Laboratory of Farmland Soil Pollution Prevention-Control and Remediation, College of Resources and Environmental Sciences, China Agricultural University, No. 2 Yuanmingyuan west road, Haidian, Beijing, 100193, People's Republic of China.

Soil acidification is a problem widely occurring worldwide, which severely threaten food security and agricultural sustainability. Calcium lignosulfonate (CaLS), a cheap and ecofriendly compound, is used for the first time to amend acid soil by utilizing its unique organic and inorganic functional moieties simultaneously. Both column leaching and incubation experiments were conducted to investigate the comparative effects of CaLS (four rates at 5, 10, 15, 20 g kg) and compared with conventional amendments, including gypsum (5 g kg), lignin (5 g kg), L + G (each at 5 g kg), and control. The soil pH, exchangeable acidity and base cations, organic carbon, and different Al fractions were determined to unravel the ameliorative performance and mechanism of the treatments. Regardless of application modes and dosages, the results demonstrated that CaLS incorporation significantly increased soil pH, exchangeable Ca, cation exchange capacity, and organic carbon and decreased the contents of exchangeable acidity, especially exchangeable Al. The ameliorative mechanism was that amendment material led to the displacement of H and Al off soil colloids by Ca. These released H and Al which complexed with lignosulfonate anions into soluble organo-Al were all quickly leached from the soil column. The CaLS addition enhanced the transformation of exchangeable Al and low-to-medium organo-Al complexes into highly stable organically bound fractions and immobilized into the soil. The complexing of CaLS functional groups with Al impeded Al from undergoing hydrolysis to produce more H. As an environmental-friendly material, CaLS can be a promising amendment for soil acidity and Al toxicity amelioration.
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http://dx.doi.org/10.1007/s11356-022-20461-1DOI Listing
May 2022

Study on the Preparation of Estrone Molecularly Imprinted Polymers and Their Application in a Quartz Crystal Microbalance Sensor via a Computer-Assisted Design.

Int J Mol Sci 2022 May 20;23(10). Epub 2022 May 20.

Institute of Mathematica, Jilin Normal University, Siping 136000, China.

Computer simulations are widely used for the selection of conditions for the synthesis of molecularly imprinted polymers and can rapidly reduce the experimental cycle time and save labor and materials. In this paper, estrone molecularly imprinted polymers (E1-MIPs) are designed at the M062X/6-311+G(,) level with itaconic acid (IA) as the functional monomer. The imprinted molar ratio between E1 and IA was optimized, cross-linkers and solvents were screened, and the nature of interactions between E1 and IA was explored. The simulated results showed that pentaerythritol triacrylate was the best cross-linker. Meanwhile, when the imprinted molar ratio between E1 and IA was 1:4, the E1-IA complex had the largest amount of hydrogen bonds, the lowest binding energy, and the strongest stability. Using the simulation results as guidance, the E1-MIPs were prepared to modify the electrons of a quartz crystal microbalance (QCM) sensor. The experimental studies showed that the E1-MIPs-QCM sensor had the highest adsorption capacity to E1 in comparison with their analogues, and the lowest detection value of the sensor was 16.00 μg/L. The computer simulations and experimental studies could provide guidance for synthesize novel E1-MIPs materials. It also could provide important references and directions for the application of E1-MIPs.
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http://dx.doi.org/10.3390/ijms23105758DOI Listing
May 2022
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