Publications by authors named "Jin Guo"

297 Publications

Identifying the Key Risk Factors of Mega Infrastructure Projects from an Extended Sustainable Development Perspective.

Int J Environ Res Public Health 2021 Jul 14;18(14). Epub 2021 Jul 14.

School of Management Science and Real Estate, Chongqing University, Chongqing 400045, China.

Mega infrastructure projects (MIPs) have become increasingly important to the realization of sustainable development in China. Sustainable development is a process of dynamic balance, and coordinating the triple bottom line (the environmental, social, and economic dimensions) will enable more sustainable development of MIPs. However, previous studies have lacked consideration of coordination when applying sustainable development principles to the systematic identification of risks to MIPs. The goals of this study were to clarify the definition and dimensions of the sustainable development of MIPs and to identify the key risks of MIPs. A literature review was performed to extend the definition of sustainable development of MIPs by combining the triple bottom line with a fourth coordination dimension. A conceptual model of MIP risk identification was then proposed from an extended sustainable development perspective, 22 sustainability elements and 75 risk factors were identified, and the key risk factors were determined based on the interview responses and fuzzy set theory. The results show that economic risks have a high probability, social risks have a high loss, environmental risks have an intermediate probability and loss, and coordination risks have the greatest impact. In addition, the three most important key risk factors were found to be construction and installation cost overruns, land acquisition and resettling cost overruns, and information sharing with the public. Identifying key risk factors can provide information to help stakeholders understand the risk factors associated with MIPs and formulate reasonable risk response strategies.
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http://dx.doi.org/10.3390/ijerph18147515DOI Listing
July 2021

Epigenetic Regulation of Hepatic Stellate Cell Activation and Macrophage in Chronic Liver Inflammation.

Front Physiol 2021 1;12:683526. Epub 2021 Jul 1.

Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

Chronic liver inflammation is a complex pathological process under different stress conditions, and the roles of stellate cells and macrophages in chronic liver inflammation have been widely reported. Moderate liver inflammation can protect the liver from damage and facilitate the recovery of liver injury. However, an inflammatory response that is too intense can result in massive death of hepatocytes, which leads to irreversible damage to the liver parenchyma. Epigenetic regulation plays a key part in liver inflammation. This study reviews the regulation of epigenetics on stellate cells and macrophages to explore the new mechanisms of epigenetics on liver inflammation and provide new ideas for the treatment of liver disease.
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http://dx.doi.org/10.3389/fphys.2021.683526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281248PMC
July 2021

TGF-β1 induced proliferation, migration, and ECM accumulation through the SNHG11/miR-34b/LIF pathway in human pancreatic stellate cells.

Endocr J 2021 Jul 15. Epub 2021 Jul 15.

Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.

Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas, and activated pancreatic stellate cells (PSCs) play a vital role in the progression of pancreatic fibrosis in CP. It has been reported that long non-coding RNA small nucleolar RNA host gene 11 (SNHG11) is highly expressed in chronic pancreatitis (CP) patients. However, the role of SNHG11 in CP progression is unclear. The purport of the study was to survey the role of SNHG11 in CP. We employed transforming growth factor (TGF)-beta1 (TGF-β1) to activate human pancreatic stellate cells (PSCs). Expression of SNHG11 was assessed with qRT-PCR. Loss-of-function experiments were executed to evaluate the effects of SNHG11 on the proliferation and migration of TGF-β1-treated PSCs. Some protein levels were detected by western blotting. The regulatory mechanism of SNHG11 was verified by the dual-luciferase reporter and RIP assays. As a result, SNHG11 was upregulated in plasma of CP patients and TGF-β1-treated PSCs. Also, SNHG11 inhibition reduced TGF-β1-induced proliferation, migration, and ECM accumulation in PSCs. Mechanistically, SNHG11 regulated leukemia inhibitory factor (LIF) expression by sponging miR-34b. Furthermore, miR-34b inhibitor abolished SNHG11 silencing-mediated effects on TGF-β1-treated PSC proliferation, migration, and ECM accumulation. LIF overexpression counteracted the repressive influence of miR-34b mimic on proliferation, migration, and ECM accumulation of TGF-β1-treated PSCs. In conclusion, SNHG11 knockdown reduced TGF-β1-induced PSC proliferation, migration, and ECM accumulation by the miR-34b/LIF axis.
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http://dx.doi.org/10.1507/endocrj.EJ21-0176DOI Listing
July 2021

Higher serum homocysteine and lower thyroid hormone levels in pregnant women are associated with neural tube defects.

J Trace Elem Med Biol 2021 Jul 2;68:126814. Epub 2021 Jul 2.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.

Background: This study tested the hypothesis that abnormal maternal metabolism of both homocysteine and thyroid hormone network in pregnant women is associated with neural tube defects (NTDs) in a part of China with high NTD prevalence.

Methods: A case-control study was performed between 2007 and 2009 in Lüliang Mountains, Shanxi Province. This study included 83 pregnant women who had fetuses with NTDs (cases) and 90 pregnant women with normal fetuses (controls). In addition, a cell model to illustrate the epidemiological findings was established.

Results: Fetuses of mother who had both high total homocysteine (tHcy) and inadequate free thyroxine were 3 times more at risk of developing NTDs (adjusted odds ratio = 3.5; 95 % confidence interval = 1.2-10.4; cases vs. controls) using multivariate logistic regression models. Furthermore, biological interaction between metabolisms of Hcy and thyroid hormones was demonstrated in vitro. In homocysteine thiolactone of a metabolite of Hcy-treated mouse embryonic neural stem NE4C cells, genes (Bmp7, Ctnnb1, Notch 1, Gli2, and Rxra) related to both neural tube closure and thyroid hormone network were shown to be regulated by H3K79 homocysteinylation, which increased their expression levels.

Conclusions: The effect of maternal serum high tHcy on risk of developing NTDs is depended on maternal serum level of thyroxine. Meanwhile, a higher level of tHcy might also affect both maternal metabolism of thyroid hormone and neural tube closure in embryogenesis through homocysteinylation of histones.
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http://dx.doi.org/10.1016/j.jtemb.2021.126814DOI Listing
July 2021

Changes of avian influenza virus subtypes before and after vaccination in live poultry in Nanchang, China from 2016 to 2019.

Microbes Infect 2021 Jun 8:104848. Epub 2021 Jun 8.

The Collaboration Unit for Field Epidemiology of State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Key Laboratory of Animal-origin and Vector-borne Diseases, Nanchang Center for Disease Control and Prevention. Nanchang 330038, PR China. Electronic address:

We investigated fluctuations in the detection rates of avian influenza virus (AIV) subtypes H5, H7, and H9 in live bird markets (LBMs) in Nanchang city, Chinese province Jiangxi, before and after the Chinese nationwide AIV vaccination campaign against highly pathogenic (HP) AIV subtype H5 and H7. Samples were tested for nucleic acid of type A avian influenza virus by real-time reverse transcription polymerase chain reaction technology. The H5, H7 and H9 subtypes of influenza viruses were further classified for the positive results. Based on the analysis of 2,119 samples collected from February 2016 to December 2019, we found that AIV subtypes H5, H7, H9 showed a seasonal pattern, and the positive rate of avian influenza tended to reach its peak in the colder season. The detection rate of AIV subtypes H5, H7, H9 of chickens (39.26%) was significantly higher than that of ducks (5.78%) and pigeons (4.31%). After vaccination, the positive rates of the H5 subtype (0.27%) and the H7 subtype (0.00%) decreased significantly, while the positive rate of the H9 subtype (29.95%) increased significantly. The H9 subtype has become the dominant subtype detected in live poultry and occupies a dominant position in the live bird market. This study showed that the government of China should establish measures for the long-term control of avian influenza.
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http://dx.doi.org/10.1016/j.micinf.2021.104848DOI Listing
June 2021

Down-Regulation of Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency.

Front Neurol 2021 19;12:579998. Epub 2021 May 19.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China.

The inositol polyphosphate-5-phosphatase E () gene is located on chromosome 9q34.3. The enzyme it encodes mainly hydrolyzes the 5-phosphate groups of phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5) P3) and phosphatidylinositol (4,5)-bisphosphate (PtdIns (4,5)P2), which are closely related to ciliogenesis and embryonic neurodevelopment, through mechanisms that are largely unknown. Here we studied the role of gene in ciliogenesis during embryonic neurodevelopment using inositol-deficiency neural tube defects (NTDs) mouse and cell models. Confocal microscopy and scanning electron microscope were used to examine the number and the length of primary cilia. The dynamic changes of expression in embryonic murine brain tissues were observed during Embryonic Day 10.5-13.5 (E 10.5-13.5). Immunohistochemistry, western blot, polymerase chain reaction (PCR) arrays were applied to detect the expression of and cilia-related genes of the embryonic brain tissues in inositol deficiency NTDs mouse. Real-time quantitative PCR (RT-qPCR) was used to validate the candidate genes in cell models. The levels of inositol and PtdIns(3,4) P2 were measured using gas chromatography-mass spectrometry (GC-MS) and enzyme linked immunosorbent assay (ELISA), respectively. Our results showed that the expression levels of gradually decreased in the forebrain tissues of the control embryos, but no stable trend was observed in the inositol deficiency NTDs embryos. expression in inositol deficiency NTDs embryos was significantly decreased compared with the control tissues. The expression levels of gene and the PtdIns (3,4) P2 levels were also significantly decreased in the inositol deficient cell model. A reduced number and length of primary cilia were observed in NIH3T3 cells when inositol deficient. Three important cilia-related genes () were down-regulated significantly in the inositol-deficient NTDs mouse and cell models, and was highly involved in NTDs. In summary, these findings suggested that down-regulation of might be associated with abnormal ciliogenesis during embryonic neurodevelopment, under conditions of inositol deficiency.
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http://dx.doi.org/10.3389/fneur.2021.579998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170399PMC
May 2021

Preparation of Ultrafiltration Membrane by Polyethylene Glycol Non-Covalent Functionalized Multi-Walled Carbon Nanotubes: Application for HA Removal and Fouling Control.

Membranes (Basel) 2021 May 17;11(5). Epub 2021 May 17.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Beijing University of Technology, Pingleyuan No.100, Beijing 100124, China.

Polyethylene glycol (PEG) non-covalent-functionalized multi-walled carbon nanotubes (MWCNT) membrane were prepared by vacuum filtration. The dispersion and stability of MWCNT non-covalent functionalized with PEG were all improved. TEM characterization and XPS quantitative analysis proved that the use of PEG to non-covalent functionalize MWCNT was successful. SEM image analysis confirmed that the pore size of PEG-MWCNT membrane was more concentrated and distributed in a narrower range of diameter. Contact angle measurement demonstrated that PEG non-covalent functionalization greatly enhanced the hydrophilicity of MWCNT membranes. The results of pure water flux showed that the PEG-MWCNT membranes could be categorized into low pressure membrane. PEG-MWCNT membrane had a better effect on the removal of humic acid (HA) and a lower TMP growth rate compared with a commercial 0.01-μm PVDF ultrafiltration membrane. During the filtration of bovine serum albumin (BSA), the antifouling ability of PEG-MWCNT membranes were obviously better than the raw MWCNT membranes. The TMP recovery rate of PEG-MWCNT membrane after cross flushing was 79.4%, while that of raw MWCNT- and MWCNT membrane were only 14.9% and 28.3%, respectively. PEG non-covalent functionalization improved the antifouling ability of the raw MWCNT membranes and reduced the irreversible fouling, which effectively prolonged the service life of MWCNT membrane.
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http://dx.doi.org/10.3390/membranes11050362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156076PMC
May 2021

Intensive induction regimens after deferring initial therapy for mantle cell lymphoma are not associated with improved survival.

Eur J Haematol 2021 May 11. Epub 2021 May 11.

Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, US.

Introduction: While most patients with mantle cell lymphoma (MCL) receive therapy shortly after diagnosis, a subset of patients with indolent-behaving disease can safely defer treatment. In this subgroup, we evaluated the importance of treatment intensity in patients with MCL who defer initial therapy.

Methods: Out of 1134 patients with MCL from 12 academic centers, we analyzed 219 patients who initiated therapy at least 90 days after diagnosis. Patients who received induction with high-dose cytarabine and/or autologous stem cell transplantation (ASCT) in first remission were considered to have received intensive therapy (n = 88) while all other approaches were non-intensive (n = 131).

Results: There was no difference in progression-free (PFS; P = .224) or overall survival (OS; P = .167) in deferred patients who received non-intensive vs. intensive therapy. Additionally, univariate and multivariate Cox proportional hazards models were performed for PFS and OS. Treatment at an academic center (HR 0.43, P = .015) was associated with improved OS in both univariate and multivariate models, while intensity of treatment was not associated with improved OS in either model.

Conclusions: These results indicate that intensified initial treatment is not associated with improved survival after deferring initial therapy, although prospective studies are needed to determine which of these patients with MCL may benefit from intensive therapy.
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http://dx.doi.org/10.1111/ejh.13649DOI Listing
May 2021

Synthesis of Ni/nano-AlO coatings by brush plating with magnetic fields.

R Soc Open Sci 2021 Mar 24;8(3):202089. Epub 2021 Mar 24.

Institute of Surface/Interface Science and Technology, Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, Harbin Engineering University, Harbin 150001, People's Republic of China.

In the process of electrodeposition, the magnetic field would generate the magneto hydrodynamic (MHD) effect, which affects the flow and mass transfer of hydrogen evolution. Thus, the performance of electrodeposition coatings will be affected. In this work, Ni/nano-AlO coatings prepared by brush plating with magnetic fields were studied. The results show that the magnetic field indeed influences the morphology, texture and wears resistance. The morphology of Ni/AlO coating is smooth and uniform; the (200) plane of Ni/AlO coating is preferentially oriented in the same direction of a magnetic field; the wear resistance of Ni/AlO composite coatings increases due to the uniform distribution of AlO particles; and the wear mechanism of coating belongs to adhesive wear. The optimal intensity of magnetic field for Ni/AlO composite coatings to obtain a good performance is 0.1 T.
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http://dx.doi.org/10.1098/rsos.202089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074909PMC
March 2021

Hydrothermal Preparation, Crystal Structure, Photoluminescence and UV-Visible Diffuse Reflectance Spectroscopic Properties of a Novel Mononuclear Zinc Complex.

Acta Chim Slov 2020 Jun;67(2):507-515

A novel mononuclear zinc complex [ZnL(Phen)(H2O)]·H2O containing the mixed ligands of Phen (Phen = 1,10-phenanthroline) and 3-hydroxy-2-methylquinoline-4-carboxylic acid (HL) was prepared by hydrothermal synthesis and its crystal structure was characterized by X-ray single-crystal diffraction method. The title complex crystallizes in the orthorhombic systems and forms monomeric units. The molecules in the title complex are connected through the interactions of hydrogen-bonding and ????? interactions to give a three-dimensional (3D) supramolecular structure. The fluorescence result discovers a wide emission band in the violet blue region. Time-dependent density functional theory (TDDFT) calculations reveal that this emission can be attributed to ligand-to-ligand charge transfer (LLCT). Solid-state diffuse reflectance shows there is a wide optical band gap.
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June 2020

Chinesisation, adaptation and validation of the Chelsea Critical Care Physical Assessment Tool in critically ill patients: a cross-sectional observational study.

BMJ Open 2021 04 9;11(4):e045550. Epub 2021 Apr 9.

Evidence-Based Medicine Center, Lanzhou University, Lanzhou, China.

Purpose: To translate and adapt the Chelsea Critical Care Physical Assessment Tool (CPAx) into Chinese version ('CPAx-Chi'), test the reliability and validity of CPAx-Chi, and verify the cut-off point for the diagnosis of intensive care unit-acquired weakness (ICU-AW).

Study Design: Cross-sectional observational study.

Methods: Forward and back translation, cross-cultural adaptation and pretesting of CPAx into CPAx-Chi were based on the Brislin model. Participants were recruited from the general ICU of five third-grade class-A hospitals in western China. Two hundred critically ill adult patients (median age: 53 years; 64% men) with duration of ICU stay ≥48 hours and Glasgow Coma Scale ≥11 were included in this study. Two researchers simultaneously and independently assessed eligible patients using the Medical Research Council Muscle Score (MRC-Score) and CPAx-Chi.

Results: The content validity index of items was 0.889. The content validity index of scale was 0.955. Taking the MRC-Score scale as standard, the criterion validity of CPAx-Chi was r=0.758 (p<0.001) for researcher A, and r=0.65 (p<0.001) for researcher B. Cronbach's α was 0.939. The inter-rater reliability was 0.902 (p<0.001). The area under the receiver operating characteristic curves of CPAx-Chi for diagnosing ICU-AW based on MRC-Score ≤48 were 0.899 (95% CI 0.862 to 1.025) and 0.874 (95% CI 0.824 to 0.925) for researcher B. The best cut-off point for CPAx-Chi for the diagnosis of ICU-AW was 31.5. The sensitivity was 87% and specificity was 77% for researcher A, whereas it was 0.621, 31.5, 75% and 87% for researcher B, respectively. The consistency was high when taking CPAx-Chi ≤31 and MRC-Score ≤48 as the cut-off points for the diagnosis of ICU-AW. Cohen's kappa=0.845 (p=0.02) in researcher A and 0.839 (p=0.04) for researcher B.

Conclusions: CPAx-Chi demonstrated content validity, criterion-related validity and reliability. CPAx-Chi showed the best accuracy in assessment of patients at risk of ICU-AW with good sensitivity and specificity at a recommended cut-off of 31.
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http://dx.doi.org/10.1136/bmjopen-2020-045550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042994PMC
April 2021

Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.

Reprod Sci 2021 Mar 24. Epub 2021 Mar 24.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, 100020, China.

Apurinic/apyrimidinic endonuclease 1/redox-factor 1 (APE1/Ref-1) gene encodes a multifunctional protein involved in the DNA base excision repair (BER) pathway, which initiates repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone. APE1/Ref-1 polymorphisms are related to the occurrence of neural tube defects (NTDs), but the association between APE1/Ref-1 polymorphisms and NTDs is not reported in Chinese Han population. The aim of the present study was to evaluate the association of APE1/Ref-1 polymorphism and the risk of NTD occurrence for Han population in a high-risk area of China. APE1/Ref-1 genotypes were determined by iPLEX Gold SNP genotyping. AP sites and folate level of brain tissues were measured. The results showed that three polymorphisms (rs3136817, rs77794916, and rs1760944) of APE1/Ref-1 were statistically associated with NTD subtypes. Allele C of rs3136817, allele T of rs77794916, and allele G of rs1760944 were associated with an increased risk for encephalocele (OR = 2.52, 95% CI [1.25-5.07], P < 0.01; OR = 1.80, 95% CI [1.04-3.12], P = 0.04; and OR = 1.96, 95% CI [1.12-3.45], P = 0.02), compared with those harboring the alleles T, C, and T, respectively. The folate level in NTDs was lower than that in controls. DNA AP sites in the encephalocele were significantly higher than the control (P < 0.01). The three polymorphisms of APE1/Ref-1 were significantly related to NTD occurrence, which indicated that APE1/Ref-1 might be a potential genetic risk factor for encephalocele in a high-risk area of NTDs in China.
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http://dx.doi.org/10.1007/s43032-021-00537-yDOI Listing
March 2021

Combinations of VC and TiC MXenes for Boosting the Hydrogen Storage Performances of MgH.

ACS Appl Mater Interfaces 2021 Mar 15;13(11):13235-13247. Epub 2021 Mar 15.

Guangxi Novel Battery Materials Research Center of Engineering Technology, Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials, Guangxi Colleges and Universities Key Laboratory of Novel Energy Materials and Related Technology, School of Physical Science and Technology, Guangxi University, Nanning 530004, China.

Two-dimensional vanadium carbide (VC) and titanium carbide (TiC) MXenes were first synthesized by exfoliating VAlC or TiAlC and then introduced jointly into magnesium hydride (MgH) to tailor the hydrogen desorption/absorption performances of MgH. The as-prepared MgH-VC-TiC composites show much better hydrogen storage performances than pure MgH. MgH with addition of 10 wt % of 2VC/TiC initiates hydrogen desorption at around 180 °C; 5.1 wt % of hydrogen was desorbed within 60 min at 225 °C, while 5.8 wt % was desorbed within 2 min at 300 °C. Under 6 MPa H, the dehydrided MgH-2VC/TiC can start to recover hydrogen at room temperature, and 5.1 wt % of H is obtained within 20 s at a constant temperature of 40 °C. The reversible capacity (6.3 wt %) does not decline for up to 10 cycles, which shows excellent cycling stability. The addition of 2VC/TiC can remarkably lower the activation energy for the hydrogen desorption reaction of MgH by 37% and slightly reduce the hydrogen desorption reaction enthalpy by 2 kJ mol H. It was demonstrated that the combination of VC and TiC promotes the hydrogen-releasing process of MgH compared with addition of only VC or TiC, while TiC impacts MgH more significantly than VC in the hydrogen absorption process of MgH at ambient temperatures. A possible mechanism in the hydrogen release and uptake of the MgH-VC-TiC system was proposed as follows: hydrogen atoms or molecules may preferentially transfer through the MgH/VC/TiC triple-grain boundaries during the desorption process and through the Mg/TiC interfaces during the absorption process. Microstructure studies indicated that VC and TiC mainly act as efficient catalysts for MgH. This work provides an insight into the hydrogen storage behaviors and mechanisms of MgH boosted by a combination of two MXenes.
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http://dx.doi.org/10.1021/acsami.0c23150DOI Listing
March 2021

Carbon Storage Change Analysis and Emission Reduction Suggestions under Land Use Transition: A Case Study of Henan Province, China.

Int J Environ Res Public Health 2021 02 14;18(4). Epub 2021 Feb 14.

School of Surveying and Land Information Engineering of Henan Polytechnic University, Jiaozuo 454000, China.

The significant spatial heterogeneity among river basin ecosystems makes it difficult for local governments to carry out comprehensive governance for different river basins in a special administrative region spanning multi-river basins. However, there are few studies on the construction of a comprehensive governance mechanism for multi-river basins at the provincial level. To fill this gap, this paper took Henan Province of China, which straddles four river basins, as the study region. The chord diagram, overlay analysis, and carbon emission models were applied to the remote sensing data of land use to analyze the temporal and spatial patterns of carbon storage caused by land-use changes in Henan Province from 1990 to 2018 to reflect the heterogeneity of the contribution of the four basins to human activities and economic development. The results revealed that food security land in the four basins decreased, while production and living land increased. Ecological conservation land was increased over time in the Yangtze River Basin. In addition, the conversion from food security land to production and living land was the common characteristic for the four basins. Carbon emission in Henan increased from 134.46 million tons in 1990 to 553.58 million tons in 2018, while its carbon absorption was relatively stable (1.67-1.69 million tons between 1990 and 2018). The carbon emitted in the Huai River Basin was the main contributor to Henan Province's total carbon emission. The carbon absorption in Yellow River Basin and Yangtze River Basin had an obvious spatial agglomeration effect. Finally, considering the current need of land spatial planning in China and the goal of carbon neutrality by 2060 set by the Chinese government, we suggested that carbon sequestration capacity should be further strengthened in Yellow River Basin and Yangtze River Basin based on their respective ecological resource advantages. For future development in Hai River Basin and Huai River Basin, coordinating the spatial allocation of urban scale and urban green space to build an ecological city is a key direction to embark upon.
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http://dx.doi.org/10.3390/ijerph18041844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918624PMC
February 2021

Effect of BaO on Hydrogen Sorption Performance of MgAl: Experimental and Theoretical Studies.

ACS Appl Mater Interfaces 2021 Mar 4;13(10):11901-11910. Epub 2021 Mar 4.

Guangxi Colleges and Universities Key Laboratory of Novel Energy Materials and Related Technology, Guangxi Novel Battery Materials Research Center of Engineering Technology, College of Physics Science and Technology, Guangxi University, Nanning 530004, P. R. China.

The MgAl-BaO composite is synthesized via mechanical milling and the effect of BaO on the hydrogen sorption properties of MgAl is studied. Experimentally, we prepare the MgAl-Ba, MgAl-BaO, MgAl-BaF, and MgAl-BaCl mixtures and find that the MgAl-BaO composite shows a superior hydrogen storage performance. For instance, the hydrogenation (dehydrogenation) enthalpy of the MgAl decreases from 62.4 (91.2) to 58.6 (71.7) kJ mol after adding BaO. When 1.0 wt % of H is absorbed/desorbed, the hydrogen absorption/desorption temperature of the MgAl-BaO is 181/271 °C, which is 73/37 °C lower than that of the MgAl. Furthermore, the catalytic mechanism of BaO on the hydrogenation of MgAl (110) surface is investigated by density functional theory (DFT). Calculations indicate that compared with the MgAl (110) surface, the adsorption energy and dissociation barrier of hydrogen on the MgAl-BaO (110) surface are both improved significantly. Our experimental and theoretical results are helpful for understanding the effect of metal oxide on hydrogen storage properties of MgAl.
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http://dx.doi.org/10.1021/acsami.0c20212DOI Listing
March 2021

A method to screen left ventricular dysfunction through ECG based on convolutional neural network.

J Cardiovasc Electrophysiol 2021 Apr 15;32(4):1095-1102. Epub 2021 Feb 15.

Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

Objective: This study aims to develop an artificial intelligence-based method to screen patients with left ventricular ejection fraction (LVEF) of 50% or lesser using electrocardiogram (ECG) data alone.

Methods: Convolutional neural network (CNN) is a class of deep neural networks, which has been widely used in medical image recognition. We collected standard 12-lead ECG and transthoracic echocardiogram (TTE) data including the LVEF value. Then, we paired the ECG and TTE data from the same individual. For multiple ECG-TTE pairs from a single individual, only the earliest data pair was included. All the ECG-TTE pairs were randomly divided into the training, validation, or testing data set in a ratio of 9:1:1 to create or evaluate the CNN model. Finally, we assessed the screening performance by overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value.

Results: We retrospectively enrolled a total of 26 786 ECG-TTE pairs and randomly divided them into training (n = 21 732), validation (n = 2 530), and testing data set (n = 2 530). In the testing set, the CNN algorithm showed an overall accuracy of 73.9%, sensitivity of 69.2%, specificity of 70.5%, positive predictive value of 70.1%, and negative predictive value of 69.9%.

Conclusion: Our results demonstrate that a well-trained CNN algorithm may be used as a low-cost and noninvasive method to identify patients with left ventricular dysfunction.
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http://dx.doi.org/10.1111/jce.14936DOI Listing
April 2021

The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells for Articular Cartilage Regeneration in Osteoarthritis.

Curr Stem Cell Res Ther 2021 Jan 27. Epub 2021 Jan 27.

Research lab of translational medicine, Hengyang Medical School, University of South China, Hengyang 421001. China.

Osteoarthritis (OA), characterized by the degeneration and destruction of articular cartilage, is one of the most significant public health issues around the world. In the course of OA, inflammatory response is an important factor leading to cartilage destruction and exacerbation of symptoms. The low immunogenicity, multi-directional differentiation and high portability properties make bone marrow mesenchymal stem cells (BMSCs) ideal seed cells for OA. Here, we review recent literature relating to the application of BMSCs for OA cell therapy and consider the following aspects: migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic effects of BMSCs, the application of biological scaffolds in cartilage regeneration by BMSCs and chondrogenic differentiation of BMSCs. Injecting BMSCs into joints with an inflammatory environment may increase the risk of osteoproliferation and ectopic calcification in patients. Further evidence and studies are needed to ensure the improvement and maintenance of the intraarticular environment for cartilage repair and regeneration.
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http://dx.doi.org/10.2174/1574888X16666210127130044DOI Listing
January 2021

Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer.

Ann Transl Med 2020 Dec;8(24):1665

Department of General Surgery, First Medical Center of the People's Liberation Army (PLA) General Hospital, Beijing, China.

Background: The past two decades have witnessed the increasing application of contralateral prophylactic mastectomy (CPM) for women with breast cancer in the western countries. Over 30% of young patients choose to underwent CPM up to 2015. However, the adoption rate of CPM has not shown a remarkably increasing in Asian countries. In China, only a few centers have introduced CPM, and no relevant literature has been published. In this study, we look forward to identify the clinical features and prognostic factors of women who underwent CPM in our hospital, to inform decision-making processes for both doctors and patients.

Methods: The clinical data of 58 eligible patients were retrospectively analyzed. Intergroup comparisons were based on independent samples -test and chi square test. The 5-year disease-free survival (DFS) and overall survival (OS) were obtained by using life tables, and factors affecting the survivals were analyzed by using the Kaplan-Meier method.

Results: The mean age of these women was 40.14±11.17 years, with 30 patients (51.7%) being ≤40 years; 13 patients (22.4%) had a family history of breast cancer; and 49 (69.0%) had known risk factors for breast cancer. The median follow-up period was 66.77 months, the 5-year OS was 89% and the 5-year DFS was 74%. The average age of onset was 41.53 (±10.964) in the disease-free survival group and 34.18 (±10.4) years in the recurrence/metastasis group, and -test revealed a significant difference in the average age between these two groups (P=0.049). Chi-square test showed that the disease progression rate significantly differed among the different age subgroups and among subjects with different body mass index (BMI) (all P≤0.05). Moreover, surgical procedure, family history of breast cancer, and some other factors showed no significant correlation with disease progression (all P>0.05). Kaplan-Meier survival analysis and log rank test further confirmed the above findings.

Conclusions: The majority of patients who choose CPM are young and with known risk factors for breast cancer. Part of the young patients (≤40 years of age) are at a higher risk of disease progression.
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http://dx.doi.org/10.21037/atm-20-7780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812232PMC
December 2020

Leveraging industrial-technological innovation to achieve sustainable development: A systems thinking perspective.

PLoS One 2020 21;15(12):e0242981. Epub 2020 Dec 21.

Research Center for Energy Economics, School of Business Administration, Henan Polytechnic University, Jiaozuo, China.

Industrial-technological innovation (ITI) has become an important requirement for the sustainable development of China. ITI development requires a comprehensive understanding of the dynamic complexity associated with ITI systems. Previous research into ITI systems is based primarily on static methods that isolate system components, and ignore feedback on adjustments made. Based on systems thinking, this paper develop six archetypes ("Limit to Growth," "Success to the Successful," "Tragedy of the Commons," "Fixes that Fail," "Accidental Adversaries," and "Shifting the Burden") and an ITI system integration model. The model visualizes the ITI system as a whole and identifies bottlenecks that may affect ITI development. This conceptual model provides a more effective method of judgment, which can better explain the operational mechanism of the ITI system and improve the system's operational characteristics. Finally, we evaluate the ITI system and propose that self-organization is a key lever of a systemic intervention framework for ITI.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242981PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751881PMC
January 2021

Quantitative analysis of low-concentration α-HMX based on terahertz spectroscopy.

Anal Methods 2020 12 17;12(47):5684-5690. Epub 2020 Nov 17.

School of Information Engineering, Southwest University of Science and Technology, Mianyang 621010, China.

Due to the instability of α type HMX at low concentrations, it belongs to the impurity crystal form. To ensure the functional effectiveness, operational reliability and management safety of HMX, it is necessary to quantify the low content of the unstable α-HMX crystal form in the composite explosive. In this study, low-concentration α-HMX is quantitatively analyzed in a mixture of α- and β-HMX. First, terahertz time-domain spectroscopy (THz-TDS) is used to obtain the absorption spectrum of the α/β-HMX element in the frequency range of 0.2-2.0 THz, and the characteristic frequency is selected. The absorption coefficient data in the frequency band of 0.7-1.3 THz are considered as the sample data for quantitative analysis. Finally, support vector machine (SVM) algorithm is used to establish a regression model, and principal component analysis (PCA) is employed for feature extraction. Grid search (GS), genetic algorithm (GA) and particle swarm optimization (PSO) are utilized for parameter optimization in support vector regression (SVR). These algorithms are combined to establish six regression models, and their effectiveness is assessed. The experimental results show that all the six methods can predict the content of α-HMX components with a small error and a high prediction accuracy. Compared to GA-SVR and PSO-SVR models, the PCA-GA-SVR and PCA-PSO-SVR models exhibit higher prediction accuracy and stability. The test set of the PCA-GA-SVR model reveals an average absolute error of 0.880%. It has the highest prediction accuracy, and the coefficient of determination (R) reaches 0.9996. This indicates that PCA and SVR can be effectively used in the detection of low-concentration HMX components and can serve as a reliable basis for the quantitative analysis of other explosives.
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http://dx.doi.org/10.1039/d0ay01583kDOI Listing
December 2020

Accumulation of the delivered dose based on cone-beam CT and deformable image registration for non-small cell lung cancer treated with hypofractionated radiotherapy.

BMC Cancer 2020 Nov 16;20(1):1112. Epub 2020 Nov 16.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

Background: This study aimed to quantify the dosimetric differences between the planned and delivered dose to tumor and normal organs in locally advanced non-small cell lung cancer (LANSCLC) treated with hypofractionated radiotherapy (HRT), and to explore the necessity and identify optimal candidates for adaptive radiotherapy (ART).

Methods: Twenty-seven patients with stage III NSCLC were enrolled. Planned radiation dose was 51Gy in 17 fractions with cone-beam CT (CBCT) acquired at each fraction. Virtual CT was generated by deformable image registration (DIR) of the planning CT to CBCT for dose calculation and accumulation. Dosimetric parameters were compared between original and accumulated plans using Wilcoxon signed rank test. Correlations between dosimetric differences and clinical variables were analyzed using Mann-Whitney U test or Chi-square test.

Results: Patients had varied gross tumor volume (GTV) reduction by HRT (median reduction rate 11.1%, range - 2.9-44.0%). The V of planning target volume for GTV (PTV-GTV) was similar between original and accumulated plans (mean, 88.2% vs. 87.6%, p = 0.452). Only 11.1% of patients had above 5% relative decrease in V of PTV-GTV in accumulated plans. Compared to the original plan, limited increase (median relative increase < 5%) was observed in doses of total lung (mean dose, V and V), esophagus (mean dose, maximum dose) and heart (mean dose, V and V) in accumulated plans. Less than 30% of patients had above 5% relative increase of lung or heart doses. Patients with quick tumor regression or baseline obstructive pneumonitis showed more notable increase in doses to normal structures. Patients with baseline obstructive atelectasis showed notable decrease (10.3%) in dose coverage of PTV-GTV.

Conclusions: LANSCLC patients treated with HRT had sufficient tumor dose coverage and acceptable normal tissue dose deviation. ART should be applied in patients with quick tumor regression and baseline obstructive pneumonitis/atelectasis to spare more normal structures.
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http://dx.doi.org/10.1186/s12885-020-07617-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670776PMC
November 2020

Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model.

Pediatr Res 2020 Nov 10. Epub 2020 Nov 10.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Background: Lithium carbonate (LiCO) is widely used in the treatment of clinical-affective psychosis. Exposure to LiCO during pregnancy increases the risk of neural tube defects (NTDs) in offspring, which are severe birth defects of the central nervous system. The mechanism of LiCO-induced NTDs remains unclear.

Methods: C57BL/6 mice were injected with different doses of LiCO intraperitoneally on gestational day 7.5 (GD7.5), and embryos collected at GD11.5 and GD13.5. The mechanisms of LiCO exposure-induced NTDs were determined utilizing immunohistochemistry, western blotting, EdU imaging, enzymatic method, gas chromatography-mass spectrometry (GC-MS), ELISA and HE staining.

Results: The NTDs incidence was 33.7% following LiCO exposure. Neuroepithelial cell proliferation and phosphohistone H3 level were significantly increased in NTDs embryos, compared with control group (P < 0.01), while the expressing levels of p53 and caspase-3 were significantly decreased. IMPase and GSK-3β activity was inhibited in LiCO-treated maternal and embryonic neural tissues (P < 0.01 and P < 0.05, respectively), along with decreased levels of inositol and metabolites, compared with control groups (P < 0.01).

Conclusions: Lithium-induced NTDs model in C57BL/6 mice was established. Enhanced cell proliferation and decreased apoptosis following lithium exposure were closely associated with the impairment of inositol biosynthesis, which may contribute to lithium-induced NTDs.

Impact: Impairment of inositol biosynthesis has an important role in lithium exposure-induced NTDs in mice model. Lithium-induced NTDs model on C57BL/6 mice was established. Based on this NTDs model, lithium-induced impairment of inositol biosynthesis resulted in the imbalance between cell proliferation and apoptosis, which may contribute to lithium-induced NTDs. Providing evidence to further understand the molecular mechanisms of lithium-induced NTDs and enhancing its primary prevention.
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http://dx.doi.org/10.1038/s41390-020-01244-1DOI Listing
November 2020

Tocilizumab mimotope alleviates kidney injury and fibrosis by inhibiting IL-6 signaling and ferroptosis in UUO model.

Life Sci 2020 Nov 23;261:118487. Epub 2020 Sep 23.

Department of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

Aims: Previously we identified four Tocilizumab mimotopes and antibodies induced by these mimotopes could bind to IL-6R (interleukin-6 receptor) and regulate the downstream signaling pathways. On the basis of obtained research data, we sought to investigate whether the therapeutic strategies by Tocilizumab mimotope vaccination could be effective in the renal fibrosis model and show the desired activity by inhibiting IL-6 signaling in current study.

Main Methods: We immunized the mice with the Tocilizumab mimotope and then performed the unilateral ureteric obstruction (UUO) surgery. Masson-trichrome staining and immunohistochemistry were performed to evaluate the renal fibrosis. The activations and differentiations of F4/80+ cells in the spleens and kidneys were detected by flow cytometry, immunohistochemistry and immunofluorescence. Signaling pathways involved IL-6, pro-fibrotic and ferroptosis were analyzed by immunoblot assay. The free iron and lipid oxidation end product were performed by Prussian blue staining and immunohistochemistry. The injury and apoptosis in the kidneys were evaluated by immunofluorescence.

Key Findings: The results showed the mimotope vaccination could reduce the level of fibrosis, injury and apoptosis by down-regulating the pro-fibrotic proteins, alleviating the activations and differentiations of macrophage F4/80+ cells in UUO models. IL-6/ERK signaling pathway was inhibited with the mimotope vaccination. The ferroptosis inhibited proteins significantly increased after the mimotope vaccination. On the contrary, the levels of free iron and lipid oxidation end product were observed to decrease in the mimotope treatment group.

Significance: Our results suggested that the Tocilizumab mimotope vaccination might be an alternative therapy to against renal fibrosis.
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http://dx.doi.org/10.1016/j.lfs.2020.118487DOI Listing
November 2020

Thermogravimetric Analysis-Fourier Transform Infrared Spectroscopy Study on the Effect of Extraction Pretreatment on the Pyrolysis Properties of Eucalyptus Wood Waste.

ACS Omega 2020 Sep 3;5(36):23364-23371. Epub 2020 Sep 3.

MOE Key Laboratory of Wooden Material Science and Application, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, China.

Eucalyptus wood is one of the important hardwood resources with attractive properties of rapid growth and good quality, which are widely used for the manufacture of wood-based boards, furniture, pulp and paper, and so on. In order to explore the potential of sawdust waste from the eucalyptus wood furniture factory as a bioenergy feedstock, its pyrolysis properties after different solvent extractions were examined using thermogravimetric analysis coupled with Fourier transform infrared spectrometry. The mass ratio of extractives in eucalyptus wood sawdust by benzene-alcohol, hot water, and sodium hydroxide solution was 4.25, 9.68, and 16.11%, respectively. After extraction, the thermal decomposition process of eucalyptus wood was promoted with a higher weight loss rate, lower activation energy, and lower residue content compared to the raw sample without pretreatment, and the promotion level was positively correlated to the strength of extracting solvent. CO, CO, CH, HO, acids, aldehydes, aromatics, ethers, and alcohols were identified as the important intermediates in pyrolysis vapors, which can be tuned by different extraction pretreatments. In terms of typical gas products, benzene-alcohol enhanced the release of carbon dioxide, and hot water enhanced the water generation from dehydration reactions and slightly increased the production of carbon monoxide, while sodium hydroxide promoted the formation of methane at the early stage under 280 °C and later stage over 460 °C during the pyrolysis of eucalyptus wood. It is believed that the extraction pretreatment can not only obtain the bioactive extractive products but also benefit the pyrolysis process by lowering the energy barrier and tuning the composition of pyrolysis products.
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http://dx.doi.org/10.1021/acsomega.0c03271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496010PMC
September 2020

Symbiotic fouling of Vetulicola, an early Cambrian nektonic animal.

Commun Biol 2020 09 18;3(1):517. Epub 2020 Sep 18.

Yunnan Key Laboratory for Palaeobiology, Institute of Palaeontology, Yunnan University, Kunming, Yunnan, 650500, China.

Here, we report the earliest fossil record to our knowledge of surface fouling by aggregates of small vermiform, encrusting and annulated tubular organisms associated with a mobile, nektonic host, the enigmatic Cambrian animal Vetulicola. Our material is from the exceptionally preserved early Cambrian (Epoch 2, Age 3), Chengjiang biota of Yunnan Province, southwest China, a circa 518 million-year old marine deposit. Our data show that symbiotic fouling relationships between species formed a component of the diversification of animal-rich ecosystems near the beginning of the Phanerozoic Eon, suggesting an early escalation of intimate ecologies as part of the Cambrian animal radiation.
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http://dx.doi.org/10.1038/s42003-020-01244-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501249PMC
September 2020

KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway.

Exp Ther Med 2020 Sep 13;20(3):2774-2782. Epub 2020 Jul 13.

Department of General Surgery, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.

Lysine demethylase 6A (KDM6A) is a Jumonji-C domain-containing histone demethylase that specifically catalyzes the removal of histone H3 lysine-27 trimethylation. KDM6A is a member of the KDM6 family, the biological role of which has been reported in various types of cancer, including bladder and lung cancer, as well as pancreatic ductal adenocarcinoma. However, the role of KDM6A in hepatocellular carcinoma (HCC) is not completely understood. Therefore, the present study aimed to determine the biological function of KDM6A in HCC progression. The expression profile of KDM6A was examined in HCC surgical specimens using reverse transcription-quantitative PCR. In addition, the role of KDM6A in the proliferation capacities of HCC cell lines was examined and using crystal violet and MTT assays. The underlying mechanism by which KDM6A exerts its function was explored by western blotting. The present study indicated that KDM6A was significantly downregulated in HCC tissues compared with normal control tissues. The role of KDM6A in HCC cell proliferation was also determined. KDM6A overexpression significantly inhibited HCC cell proliferation, whereas KDM6A knockdown significantly promoted HCC cell proliferation compared with the corresponding control groups. Consistently, KDM6A overexpression suppressed HCC cell tumorigenesis . The western blotting results indicated that KDM6A overexpression decreased the phosphorylation levels of smad2, whereas KDM6A knockdown increased the phosphorylation levels of smad2 compared with the corresponding control groups. Therefore, the present study suggested that KDM6A may inhibit HCC cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway, suggesting that KDM6A may serve as a potential target for the diagnosis and treatment of HCC.
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http://dx.doi.org/10.3892/etm.2020.9000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401926PMC
September 2020

An experimental investigation on the interaction between inlet swirl distortion and a low-speed axial compressor.

Sci Prog 2020 Jul-Sep;103(3):36850420940920

College of Energy and Power Engineering, Nanjing University of Aeronautics and Astronautics, Jiangsu Province Key Laboratory of Aerospace Power Systems, Nanjing, China.

The aim of this article mainly lies in two aspects. The first is to investigate the effect of inlet swirl distortion on the performance and stability of a low-speed compressor experimentally. The second is to quantify swirl pattern revolution through the compressor and find out background causes of the change in compressor performance. Swirl distortion makes the leading-edge incidence opposite between tip and hub regions, compared to that of clean flow. And the compressor performance change is ultimately determined by these two aspects. Results indicate that negative bulk swirl improves pressure rise, and the effect is on the contrary to the positive bulk swirl. Under the condition of paired swirl, pressure rise also presents a reduction. All these three types of swirl have little effect on the stall boundary. Although swirl distortion shows clear recovery at rotor exit, downstream components still work at off-design conditions due to the induced nonuniformity in axial velocity and total pressure.
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http://dx.doi.org/10.1177/0036850420940920DOI Listing
July 2020

Serum uric acid and incident atrial fibrillation: A systematic review and dose-response meta-analysis.

Clin Exp Pharmacol Physiol 2020 11 6;47(11):1774-1782. Epub 2020 Aug 6.

Department of Integrated TCM & Western Medicine, Mindong Hospital Affiliated to Fujian Medical University, Fu'an, China.

The exposure-effect association between serum uric acid and atrial fibrillationis not well known. We conduct a meta-analysis to quantitatively examine the exposure-effect relationship between serum uric acid and atrial fibrillation. Prospective studies (including cohort or nested case-control) that reported the serum uric acid and atrial fibrillation were identified through electronic searches using EMBASE, PubMed, and the Cochrane Library database. The exposure-effect analysis was performed using a stage robust error meta-regression. Eleven studies were included, with a total of 6831 cases of atrial fibrillation among 527 908 individuals. Both the highest (risk ratio (RR), 1.9; 95% confidence interval (CI), 1.64-2.23; I  = 0%) and intermediate (RR, 1.36; 95% CI, 1.16-1.59; I  = 36%) level of serum uric acid were associated with increased risks of atrial fibrillation compared to the patients with the lowest level of serum uric acid. In the exposure-effect analysis, for each 1 mg/dL increase in serum uric acid level, the incidence of atrial fibrillation increased by 21% (RR, 1.21; 95% CI, 1.12-1.32; I  = 78%). Furthermore, a significant positive linear relationship between serum uric acid and the risk of atrial fibrillation, P  = 0.47 was found. The exposure-effect analysis demonstrated that serum uric acid over 5.0 mg/dL significantly increased the risk of atrial fibrillation. There was a positive linear association between serum uric acid and risk of atrial fibrillation, both in subjects with noruricaemia and hyperuricaemia. More studies are needed to explore the impact of serum uric acid reduction on the incidence of atrial fibrillation.
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http://dx.doi.org/10.1111/1440-1681.13374DOI Listing
November 2020

Acceleration of biofilm formation in start-up of sequencing batch biofilm reactor using carriers immobilized with Pseudomonas stutzeri strain XL-2.

Bioresour Technol 2020 Oct 26;314:123736. Epub 2020 Jun 26.

Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, PR China.

P. stutzeri strain XL-2 initially immobilized on polypropylene carriers accelerated the biofilm formation in start-up of sequencing batch biofilm reactor (SBBR) (denoted R1). The biofilm formation in R1 was approximately completed in 36 days, which was shorter than that of 48 days in an identical SBBR (denoted R2) without strain XL-2. Meanwhile, R1 presented a rapid stabilization of NH-N and TN removal to 81.7% and 72.4% respectively. Surface plasmon resonance demonstrated that strain XL-2 enhanced the initial adhesion of carrier surface due to the production of extracellular polymeric substances (EPS), which made it easier for other EPS-producing strains, such as Thauera and Flavobacterium, to adhere to the carriers. PICRUSt revealed that biofilm in R1 presented relatively higher activity of EPS biosynthesis enzymes (glycosyltransferase and asparagine synthase). Thus, high EPS content was obtained due to the application of carriers immobilized with strain XL-2 and finally promoted the biofilm formation.
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http://dx.doi.org/10.1016/j.biortech.2020.123736DOI Listing
October 2020

Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs.

Animals (Basel) 2020 Jun 29;10(7). Epub 2020 Jun 29.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

MeiShan and Large White pigs differ in their female fecundity. However, the mechanisms behind the gene expression and regulation that cause these differences remain unclear. In this study, we profiled circRNAs and identified 5,879 circRNAs from the ovaries of MeiShan and Large White pigs. Eighty-five circRNAs were differentially expressed between the two pig breeds. Of these, 37 were up-regulated and 48 were down-regulated in MeiShan pigs. Gene ontology enrichment analysis suggested that the differentially expressed circRNA were involved in the hormone-mediated signaling pathway. We verified that and its parent gene, scinderin (), were differentially expressed by reverse transcription and quantitative PCR (RT-qPCR). Luciferase assays demonstrated that can target and sponge miR-133 and miR-148a/b. The identification of differentially expressed circRNAs (DECs) and their regulatory functions increased our understanding of the differences in reproductive efficiency between MeiShan and Large White pigs.
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http://dx.doi.org/10.3390/ani10071114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401585PMC
June 2020
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