Jill P Smith

Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer.

Authors:

Martha D Gay Anita Safronenka Hong Cao Felice H Liu Zoe X Malchiodi Robin D Tucker Alexander Kroemer Narayan Shivapurkar Jill P Smith

Cancer Prev Res (Phila) 2020 Oct 28. Epub 2020 Oct 28.

Department of Medicine, Georgetown University College of Medicine, Washington, DC.

View Article and Find Full Text PDF

October 2020

Role of the δ-Opioid Receptor in 2 Murine Models of Colitis.

Authors:

Tia R Bobo Leo R Fitzpatrick Tiffany L Whitcomb Timothy K Cooper Sorana Raiciulescu Jill P Smith

Comp Med 2020 02 22;70(1):25-34. Epub 2020 Jan 22.

Department of Medicine, Penn State College of Medicine, Hershey, Pennsylvania; Department of Medicine, Georgetown University, Washington, DC.

View Article and Find Full Text PDF

February 2020

A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.

Authors:

Jun Zhong Ashley Jermusyk Lang Wu Jason W Hoskins Irene Collins Evelina Mocci Mingfeng Zhang Lei Song Charles C Chung Tongwu Zhang Wenming Xiao Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja Berndt Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Federico Canzian Erica J Childs Michelle Cotterchio Mengmeng Du Eric J Duell Charles Fuchs Steven Gallinger J Michael Gaziano Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Elizabeth A Holly Eric A Klein Manolis Kogevinas Robert J Kurtz Loic LeMarchand Núria Malats Satu Männistö Roger Milne Rachel E Neale Kimmie Ng Ofure Obazee Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Sabina Sieri Debra Silverman Malin Sund Anne Tjønneland Mark D Thornquist Geoffrey S Tobias Antonia Trichopoulou Stephen K Van Den Eeden Kala Visvanathan Jean Wactawski-Wende Nicolas Wentzensen Emily White Herbert Yu Chen Yuan Anne Zeleniuch-Jacquotte Robert Hoover Kevin Brown Charles Kooperberg Harvey A Risch Eric J Jacobs Donghui Li Kai Yu Xiao-Ou Shu Stephen J Chanock Brian M Wolpin Rachael Z Stolzenberg-Solomon Nilanjan Chatterjee Alison P Klein Jill P Smith Peter Kraft Jianxin Shi Gloria M Petersen Wei Zheng Laufey T Amundadottir

J Natl Cancer Inst 2020 Oct;112(10):1003-1012

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article and Find Full Text PDF

October 2020

ISG15 pathway knockdown reverses pancreatic cancer cell transformation and decreases murine pancreatic tumor growth via downregulation of PDL-1 expression.

Authors:

Julian Burks Alia Fleury Sarah Livingston Jill P Smith

Cancer Immunol Immunother 2019 Dec 11;68(12):2029-2039. Epub 2019 Nov 11.

Department of Medicine, Georgetown University, Washington, DC, 20007, USA.

View Article and Find Full Text PDF

December 2019

Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis.

Authors:

Sandeep Nadella Victor Ciofoaia Hong Cao Bhaskar Kallakury Robin D Tucker Jill P Smith

Dig Dis Sci 2020 05 9;65(5):1376-1384. Epub 2019 Oct 9.

Department of Medicine, Georgetown University, 4000 Reservoir Rd, NW, Building D, Room 338, Washington, DC, 20007, USA.

View Article and Find Full Text PDF

May 2020

Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment.

Authors:

Nicholas Osborne Rebecca Sundseth Julian Burks Hong Cao Xunxian Liu Alexander H Kroemer Lynda Sutton Allen Cato Jill P Smith

Cancer Immunol Immunother 2019 Oct 24;68(10):1635-1648. Epub 2019 Sep 24.

Department of Medicine, Georgetown University, 4000 Reservoir Rd, NW, Building D, Room 338, Washington, DC, 20007, USA.

View Article and Find Full Text PDF

October 2019

Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases.

Authors:

Nicholas Osborne Rebecca Sundseth Martha D Gay Hong Cao Robin D Tucker Sandeep Nadella Shangzi Wang Xunxian Liu Alexander Kroemer Lynda Sutton Allen Cato Jill P Smith

Am J Physiol Gastrointest Liver Physiol 2019 11 21;317(5):G682-G693. Epub 2019 Aug 21.

Department of Medicine, Georgetown University, Washington, District of Columbia.

View Article and Find Full Text PDF

November 2019

A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma.

Authors:

Robin D Tucker Victor Ciofoaia Sandeep Nadella Martha D Gay Hong Cao Matthew Huber Anita Safronenka Narayan Shivapurkar Bhaskar Kallakury Annie J Kruger Alexander H K Kroemer Jill P Smith

Dig Dis Sci 2020 01 11;65(1):189-203. Epub 2019 Jul 11.

Department of Medicine, Georgetown University, 4000 Reservoir Rd, NW, Building D, Room 338, Washington, DC, 20007, USA.

View Article and Find Full Text PDF

January 2020

Endogenous Gastrin Collaborates With Mutant KRAS in Pancreatic Carcinogenesis.

Authors:

Sandeep Nadella Julian Burks Matthew Huber Juan Wang Hong Cao Bhaskar Kallakury Robin D Tucker Simina M Boca Ashley Jermusyck Irene Collins Eveline E Vietsch Mariaelena Pierobon K Alex Hodge Waxing Cui Laufey T Amundadottir Emanuel Petricoin Narayan Shivapurkar Jill P Smith

Pancreas 2019 08;48(7):894-903

From the Department of Medicine.

View Article and Find Full Text PDF

August 2019

Cholecystokinin Receptor-Targeted Polyplex Nanoparticle Inhibits Growth and Metastasis of Pancreatic Cancer.

Authors:

Julian Burks Sandeep Nadella Abdullah Mahmud Charoen Mankongpaisarnrung Juan Wang Jong-In Hahm Robin D Tucker Narayan Shivapurkar Stephan T Stern Jill P Smith

Cell Mol Gastroenterol Hepatol 2018 7;6(1):17-32. Epub 2018 Mar 7.

Department of Medicine, Georgetown University, Washington, District of Columbia.

View Article and Find Full Text PDF

March 2018

Dietary fat stimulates pancreatic cancer growth and promotes fibrosis of the tumor microenvironment through the cholecystokinin receptor.

Authors:

Sandeep Nadella Julian Burks Abdulhameed Al-Sabban Gloria Inyang Juan Wang Robin D Tucker Marie E Zamanis William Bukowski Narayan Shivapurkar Jill P Smith

Am J Physiol Gastrointest Liver Physiol 2018 11 21;315(5):G699-G712. Epub 2018 Jun 21.

Department of Medicine, Georgetown University , Washington, District of Columbia.

View Article and Find Full Text PDF

November 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:

Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

View Article and Find Full Text PDF

February 2018

Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice.

Authors:

Jill P Smith Shangzi Wang Sandeep Nadella Sandra A Jablonski Louis M Weiner

Cancer Immunol Immunother 2018 02 17;67(2):195-207. Epub 2017 Oct 17.

Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA.

View Article and Find Full Text PDF

February 2018

Effect of liver histopathology on islet cell engraftment in the model mimicking autologous islet cell transplantation.

Authors:

Chirag S Desai Khalid M Khan Xiaobo Ma Henghong Li Juan Wang Lijuan Fan Guoling Chen Jill P Smith Wanxing Cui

Islets 2017 11 13;9(6):140-149. Epub 2017 Sep 13.

c Islet Cell Laboratory, Medstar Georgetown University Hospital , Washington DC , USA.

View Article and Find Full Text PDF

November 2017

Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer.

Authors:

Welley S Loc Samuel S Linton Zachary R Wilczynski Gail L Matters Christopher O McGovern Thomas Abraham Todd Fox Christopher M Gigliotti Xiaomeng Tang Amra Tabakovic Jo Ann Martin Gary A Clawson Jill P Smith Peter J Butler Mark Kester James H Adair

Nanomedicine 2017 Oct 1;13(7):2313-2324. Epub 2017 Jul 1.

Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA, USA; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Biomedical Engineering/Bioengineering, Pennsylvania State University, University Park, PA, USA. Electronic address:

View Article and Find Full Text PDF

October 2017