Jill P Smith

Jill P Smith

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Jill P Smith

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ISG15 pathway knockdown reverses pancreatic cancer cell transformation and decreases murine pancreatic tumor growth via downregulation of PDL-1 expression.

Cancer Immunol Immunother 2019 Dec 11;68(12):2029-2039. Epub 2019 Nov 11.

Department of Medicine, Georgetown University, Washington, DC, 20007, USA.

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http://dx.doi.org/10.1007/s00262-019-02422-9DOI Listing
December 2019

Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases.

Am J Physiol Gastrointest Liver Physiol 2019 Nov 21;317(5):G682-G693. Epub 2019 Aug 21.

Department of Medicine, Georgetown University, Washington, District of Columbia.

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http://dx.doi.org/10.1152/ajpgi.00145.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879893PMC
November 2019

Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment.

Cancer Immunol Immunother 2019 Oct 24;68(10):1635-1648. Epub 2019 Sep 24.

Department of Medicine, Georgetown University, 4000 Reservoir Rd, NW, Building D, Room 338, Washington, DC, 20007, USA.

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http://dx.doi.org/10.1007/s00262-019-02398-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814262PMC
October 2019

Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis.

Dig Dis Sci 2019 Oct 9. Epub 2019 Oct 9.

Department of Medicine, Georgetown University, 4000 Reservoir Rd, NW, Building D, Room 338, Washington, DC, 20007, USA.

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http://dx.doi.org/10.1007/s10620-019-05863-5DOI Listing
October 2019

A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma.

Dig Dis Sci 2019 Jul 11. Epub 2019 Jul 11.

Department of Medicine, Georgetown University, 4000 Reservoir Rd, NW, Building D, Room 338, Washington, DC, 20007, USA.

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http://dx.doi.org/10.1007/s10620-019-05722-3DOI Listing
July 2019

Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice.

Cancer Immunol Immunother 2018 02 17;67(2):195-207. Epub 2017 Oct 17.

Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA.

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http://dx.doi.org/10.1007/s00262-017-2077-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801048PMC
February 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:
Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-02942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680PMC
February 2018

Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer.

Nanomedicine 2017 Oct 1;13(7):2313-2324. Epub 2017 Jul 1.

Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA, USA; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Biomedical Engineering/Bioengineering, Pennsylvania State University, University Park, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625839PMC
October 2017

Gastrin and Gastric Cancer.

Cell Mol Gastroenterol Hepatol 2017 Jul 14;4(1):75-83. Epub 2017 Mar 14.

Cato Research, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.jcmgh.2017.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439238PMC
July 2017

A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma.

Nucleic Acid Ther 2017 Feb 18;27(1):23-35. Epub 2016 Oct 18.

5 Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine , Hershey, Pennsylvania.

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http://dx.doi.org/10.1089/nat.2016.0621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312616PMC
February 2017

The Role of Gastrin and CCK Receptors in Pancreatic Cancer and other Malignancies.

Int J Biol Sci 2016 28;12(3):283-91. Epub 2016 Jan 28.

3. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.7150/ijbs.14952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753157PMC
December 2016

Germline Mutation of the CCK Receptor: A Novel Biomarker for Pancreas Cancer.

Clin Transl Gastroenterol 2016 Jan 7;7:e134. Epub 2016 Jan 7.

Department of Medicine, Pennsylvania State University School of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ctg.2015.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737870PMC
January 2016

Distribution of cholecystokinin-B receptor genotype between patients with pancreatic cancer and controls and its impact on survival.

Pancreas 2015 Mar;44(2):236-42

From the *Department of Medicine, Georgetown University, Washington, DC; †Department of Medicine, Pennsylvania State University, College of Medicine, Hershey; ‡Department of Medicine, University of Pittsburgh; §University of Pittsburgh Medical Center, Pittsburgh; Departments of ∥Biochemistry and Molecular Biology, and ¶Public Health Sciences, Pennsylvania State University, College of Medicine, Hershey, PA; and #Department of Epidemiology, University of Texas at MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/MPA.0000000000000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326549PMC
March 2015

Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice.

Pancreas 2014 Oct;43(7):1050-9

From the *National Institute of Diabetes and Digestive and Kidney Disease, The National Institutes of Health, Bethesda, MD; Departments of †Medicine, ‡Comparative Medicine and Pathology, §Public Health Sciences, and ∥Biochemistry and Molecular Biology, The Pennsylvania State University, College of Medicine, Hershey, PA; and ¶National Institute of Dental and Craniofacial Research, The National Institutes of Health, Bethesda, MD.

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https://insights.ovid.com/crossref?an=00006676-201410000-000
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http://dx.doi.org/10.1097/MPA.0000000000000194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161619PMC
October 2014

Novel strategies for managing pancreatic cancer.

World J Gastroenterol 2014 Oct;20(40):14717-25

Welley S Loc, Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.

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http://dx.doi.org/10.3748/wjg.v20.i40.14717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209537PMC
October 2014

Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat.

Dig Dis Sci 2014 Jun 11;59(6):1180-91. Epub 2014 May 11.

Department of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1007/s10620-014-3201-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096234PMC
June 2014

Cholecystokinin and pancreatic cancer: the chicken or the egg?

Am J Physiol Gastrointest Liver Physiol 2014 Jan 31;306(2):G91-G101. Epub 2013 Oct 31.

6707 Democracy Blvd., Rm. 655, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1152/ajpgi.00301.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073990PMC
January 2014

Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop.

Pancreas 2013 Nov;42(8):1227-37

From the *Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; †Department of Surgery, Karolinska Institute, Stockholm, Sweden; ‡Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain; §Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; ∥Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN; ¶Department of Epidemiology, Mayo Graduate School of Medicine, Rochester, MN; and #Departments of Medicine, Cell Biology and Physiology, and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1097/MPA.0b013e3182a9ad9dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878448PMC
November 2013

Safety and tolerability of low-dose naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study.

J Clin Gastroenterol 2013 Apr;47(4):339-45

Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1097/MCG.0b013e3182702f2bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586944PMC
April 2013

Therapeutic effect of vitamin d supplementation in a pilot study of Crohn's patients.

Clin Transl Gastroenterol 2013 Apr 18;4:e33. Epub 2013 Apr 18.

Department of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, University Park, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ctg.2013.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636524PMC
April 2013

Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis.

Am J Physiol Gastrointest Liver Physiol 2012 Jun 22;302(11):G1244-52. Epub 2012 Mar 22.

Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, 17033, USA.

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http://dx.doi.org/10.1152/ajpgi.00460.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378167PMC
June 2012

Calcium phosphosilicate nanoparticles for imaging and photodynamic therapy of cancer.

Discov Med 2012 Apr;13(71):275-85

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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April 2012

Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial.

Dig Dis Sci 2011 Jul 8;56(7):2088-97. Epub 2011 Mar 8.

Department of Medicine, The Pennsylvania State University, College of Medicine, GI Medicine H-045, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1007/s10620-011-1653-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381945PMC
July 2011

Role of endogenous cholecystokinin on growth of human pancreatic cancer.

Int J Oncol 2011 Mar 24;38(3):593-601. Epub 2010 Dec 24.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.3892/ijo.2010.886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282828PMC
March 2011

Opioid growth factor improves clinical benefit and survival in patients with advanced pancreatic cancer.

Open Access J Clin Trials 2010 Mar;2010(2):37-48

Department of Medicine, Pennsylvania State University, College of Medicine, Hershey Medical Center, Hershey, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947031PMC
http://dx.doi.org/10.2147/oajct.s8270DOI Listing
March 2010

Surgical management of portal hypertension in Felty's syndrome: A case report and literature review.

J Hepatol 2009 Apr 12;50(4):831-5. Epub 2009 Feb 12.

Department of Internal Medicine, Harrisburg Hospital, Harriburg, PA, USA.

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http://dx.doi.org/10.1016/j.jhep.2008.10.035DOI Listing
April 2009

The opioid antagonist naltrexone improves murine inflammatory bowel disease.

J Immunotoxicol 2008 Apr;5(2):179-87

Departments of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1080/15476910802131469DOI Listing
April 2008

Low-dose naltrexone therapy improves active Crohn's disease.

Am J Gastroenterol 2007 Apr 11;102(4):820-8. Epub 2007 Jan 11.

Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1111/j.1572-0241.2007.01045.xDOI Listing
April 2007

Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma.

Cancer Chemother Pharmacol 2005 Nov 10;56(5):510-20. Epub 2005 Jun 10.

Department of Neural and Behavioral Sciences, H109, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, 17033, USA.

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http://dx.doi.org/10.1007/s00280-005-1028-xDOI Listing
November 2005

The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancer.

Pancreas 2004 Nov;29(4):271-7

Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1097/00006676-200411000-00005DOI Listing
November 2004

Amantadine therapy for chronic hepatitis C: a dose escalation study.

Am J Gastroenterol 2004 Jun;99(6):1099-104

Department of Medicine, Pennsylvania State University College of Medicine, The M.S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850, USA.

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http://dx.doi.org/10.1111/j.1572-0241.2004.30798.xDOI Listing
June 2004

Amantadine therapy for chronic hepatitis C.

J Gen Intern Med 2004 Jun;19(6):662-8

Department of Medicine, Pennsylvania State College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1111/j.1525-1497.2004.30057.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1492374PMC
June 2004

Functional significance of gastrin gene expression in human cancer cells.

Regul Pept 2004 Mar;117(3):167-73

Department of Medicine, Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.regpep.2003.10.013DOI Listing
March 2004

Treatment of advanced pancreatic cancer with opioid growth factor: phase I.

Anticancer Drugs 2004 Mar;15(3):203-9

Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1097/00001813-200403000-00003DOI Listing
March 2004

Characterization of the CCK-C (cancer) receptor in human pancreatic cancer.

Int J Mol Med 2002 Dec;10(6):689-94

Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.

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December 2002