Publications by authors named "Jie Zhao"

1,587 Publications

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Effectiveness of a Cloud-Based Telepathology System in China: Large-Sample Observational Study.

J Med Internet Res 2021 Jul 29;23(7):e23799. Epub 2021 Jul 29.

National Telemedicine Center of China, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Whole-slide imaging allows the entire slide to be viewed in a manner that simulates microscopy; therefore, it is widely used in telepathology. However, managing the large digital files needed for whole-slide imaging is difficult. To solve this problem, we set up the Chinese National Cloud-Based Telepathology System (CNCTPS). CNCTPS has been running for more than 4 years and has accumulated a large amount of data.

Objective: The main purpose of this study was to comprehensively evaluate the effectiveness of the CNCTPS based on a large sample. The evaluation indicators included service volume, turnaround time, diagnosis accuracy, and economic benefits.

Methods: Details of 23,167 cases submitted to the CNCTPS from January 2016 to December 2019 were collected to analyze the service volume, turnaround time, and economic benefits. A total of 564 patients who visited the First Affiliated Hospital of Zhengzhou University and obtained final diagnoses were followed up to analyze the diagnostic accuracy of the CNCTPS.

Results: From 2016 to 2019, the service volume of the CNCTPS increased from 2335 to 9240, and the number of participating hospitals increased from 60 to 74. Consultation requests from county-level hospitals accounted for 86.57% (20,287/23,167). A total of 17,495 of 23,167 cases (75.52%) were confirmed, including 12,088 benign lesions, 5217 malignant lesions, and 190 borderline lesions. Of the cases, 3.85% (893/23,167) failed to be diagnosed for reasons such as poor slice quality and incomplete sampling. The median turnaround time was 16.93 hours and was shortened yearly (between 2018 and 2019: adjusted P=.01; other groups: adjusted P<.001); 82.88% cases were diagnosed in 48 hours. There was a discrepancy between the diagnosis and final diagnosis for 11 cases, including 4 false-positive cases and 7 false-negative cases. The sensitivity and specificity were 97.66% and 98.49%, respectively. The diagnostic accuracy of the system was 98.05%, with no statistical difference from the final diagnosis in the hospital (P=.55). By using this system, a total of US $300,000 was saved for patients every year.

Conclusions: The novel cloud-based telepathology system has the potential to relieve the shortage of pathologists in primary hospitals. It can also simultaneously reduce medical costs for patients in China. It should, therefore, be further promoted to enhance the efficiency, quantity, and quality of telepathology diagnoses.
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http://dx.doi.org/10.2196/23799DOI Listing
July 2021

Do cropping system and fertilization rate change water-stable aggregates associated carbon and nitrogen storage?

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.

Soil aggregates not only store carbon (C) and nitrogen (N) but hold a critical role in determining the nutrients supply, crop productivity, and climate change mitigation. However, the impact of cropping system and N fertilization on aggregate-associated C and N in both topsoil and subsoil remains unclear. Here, we assessed the effect of cropping systems (wheat-soybean vs. wheat-maize cropping systems) and N fertilization rates (0 N; medium N, 120 kg N ha; high N, 240 kg N ha) on soil water-stable aggregates distribution, as well as aggregate-associated C and N based on a field study in North China Plain. Our study suggests that the variations of soil organic carbon (SOC) and total nitrogen (TN) stocks were more affected by N fertilization than short-term cropping systems. In the wheat-soybean system, medium N increased the SOC stock by 19.18% and 15.73% as compared to high N in the topsoil and subsoil, respectively. Additionally, medium N resulted in 6.59-18.11% higher TN stock in the topsoil for both wheat-soybean and wheat-maize cropping systems as compared to 0 N and high N. Notably, the water-stable macroaggregates (> 0.25 mm) in the topsoil occupied more than 70% of the soil, which increased under medium N in the wheat-soybean cropping system. In conclusion, medium N fertilization combined with a legume-based cropping could be used to improve SOC stock, promote soil aggregation, and enhance aggregate-associated C.
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http://dx.doi.org/10.1007/s11356-021-15562-2DOI Listing
July 2021

Effect of citric acid residue and short-chain fatty acids on fermentation quality and aerobic stability of lucerne ensiled with lactic acid bacteria inoculants.

J Appl Microbiol 2021 Jul 26. Epub 2021 Jul 26.

Institute of Ensiling and Processing of Grass, College of Agro-Grassland Science, Nanjing Agricultural University, Weigang 1, Nanjing, 210095, China.

Aims: The experiment aimed to compare the effects of citric acid residue (CAR) to that of three commonly used short-chain fatty acids on the fermentation quality, aerobic stability and structural carbohydrate degradation of lucerne ensiled with lactic acid bacteria (LAB) inoculants.

Methods And Results: Fresh lucerne was ensiled with distilled water (control), LAB inoculant (L), CAR + LAB inoculant (CL), formic acid + LAB inoculant (FL), acetic acid + LAB inoculant (AL) and propanoic acid + LAB inoculant (PL) for 50 days. Chemical composition and microbial populations were determined after ensiling. The residual silages ensiled for 50 days were evaluated for aerobic stability. Compared to control, CL, FL, AL and PL treatments significantly (P<0.05) decreased pH, ammonia nitrogen (NH -N) and butyric acid contents, and increased lactic acid, acetic acid and propionic acid contents. Among them, CL silages had the lowest pH, dry matter (DM) and water-soluble carbohydrate (WSC) content, while the population of LAB and the lactic acid contents were highest. Besides, CL outperformed in enhancing fiber degradation, CL silages significantly decreased (P<0.05) NDF, ADF, hemicellulose and cellulose contents compared to control and had the highest Flieg's point. All treated-silages improved the aerobic stability compared with control, of which L improved 32 h, while CL, FL, AL and PL improved 46, 20, 46, >64 h, respectively.

Conclusion: Applying a combination of CAR and LAB inoculant improved fermentation quality and structural carbohydrate degradation of lucerne silage and had a similar effect on aerobic stability compared to other three short-chain fatty acids.

Significance And Impact Of The Study: The CAR had a comparable effect on enhancing fermentation quality as compared with three short-chain fatty acids. Thus, the combination of CAR and LAB inoculant might be utilized as an ideal additive for lucerne silage making with low WSC and high moisture content.
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http://dx.doi.org/10.1111/jam.15236DOI Listing
July 2021

Exploring the ensiling characteristics and bacterial community of red clover inoculated with the epiphytic bacteria from temperate gramineous grasses.

J Appl Microbiol 2021 Jul 26. Epub 2021 Jul 26.

Institute of Ensiling and Processing of Grass, College of Agro-Grassland Science, Nanjing Agricultural University, Nanjing, 210095, China.

Aims: To explore the microbiological factors that cause the difference in silage fermentation characteristics between temperate gramineous (Italian ryegrass and oat) grass and legume forage.

Methods And Results: Through γ-ray irradiation sterilization and bacterial transplantation technology, the sterilized red clover was inoculated as follows: (i) aseptic water (STRC); (ii) epiphytic bacteria on red clover (RCRC); (iii) epiphytic bacteria on oat (RCOT); (iv) epiphytic bacteria on Italian ryegrass (RCIR). Red clover was ensiled in laboratory-scale silos made of vacuum-packed plastic bags for 1, 3, 7, 14, 30 and 60 days. STRC remained unfermented state based on similar chemical components with fresh red clover. Compared with RCRC and RCIR, higher lactic acid content and ratio of lactic acid to acetic acid, and lower pH, acetic acid and ammonia nitrogen contents were observed in RCOT after 60 days of ensiling. Using next generation sequencing, higher abundances of Methylobacterium and Sphingomonas were observed in the epiphytic bacteria on red clover. Pediococcus was dominant in RCRC after 3 days of ensiling. Lactobacillus was the most predominant in each group after 60 days of fermentation. RCRC and RCIR had a more hetero-fermentative process, while RCOT possessed a more homo-fermentative pathway. According to the 16S rRNA gene-predicted functional profiles, the metabolism of amino acids was accelerated by the epiphytic bacteria from red clover.

Conclusions: Inoculating the epiphytic bacteria from oat could alter the fermentation characteristics and bacterial compositions of red clover silage. The relative abundance and activity of Methylobacterium, Sphingomonas, Enterobacteriaceae and hetero-fermentative Lactobacillus in red clover silage could be changed by the epiphytic bacteria on temperate gramineous grass.

Significance And Impact Of The Study: The exogenous microorganisms inhibiting the metabolism of amino acids can be a good potential source to improve the silage quality of legume forage.
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http://dx.doi.org/10.1111/jam.15234DOI Listing
July 2021

[Microbial Community Structure of Activated Sludge and its Response to Environmental Factors].

Huan Jing Ke Xue 2021 Aug;42(8):3886-3893

Key Laboratory of Environmental Engineering of Shaanxi Province, Xi'an University of Architecture and Technology, Xi'an 710055, China.

By mining and analyzing the published 16S rRNA amplification data of activated-sludge from 32 sewage and waste-water treatment facilities, at home and abroad, this study examines the microbial structure of sludge and its response to inflow water quality, temperature, and treatment type. Activated sludge generally shows high species diversity and community richness. Many activated sludge samples contain different microbial community structures. In these samples, the dominant bacteria included , , , , , , and . Temperature was negatively correlated with several key denitrifying microorganisms, such as , , , and . When temperatures were lower than 15℃, the corresponding removal rates of TN and NH-N in the 32 sewage treatment plants only reached 49.67% and 63.19%, respectively. With higher BOD/COD values, these sewage treatment systems exhibited improved biodegradability performances. With higher relative abundances of advantageous functional bacteria, such as , , , and , pollutant-removal rates would increase accordingly. As for domestic-sewage treatments, the performance of the AO process is superior to that of the OD, CAS, and CMAS processes. Additionally, the relative abundances of multiple functional dominant bacteria, including , , , and , were significantly higher in sludge treated with the AO process than in sludge treated with the other three processes.
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http://dx.doi.org/10.13227/j.hjkx.202012191DOI Listing
August 2021

Ensiling pretreatment with two novel microbial consortia enhances bioethanol production in sterile rice straw.

Bioresour Technol 2021 Jul 6;339:125507. Epub 2021 Jul 6.

Institute of Ensiling and Processing of Grass, College of Agro-grassland Science, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

The present study extracts and enriches cellulolytic microbial consortia from yak (Bos grunniens) and evaluates their effects on the fermentation profile and bioethanol yield in rice straw silage. Two microbial consortia (CF and PY) with high cellulolytic activity were isolated and observed to be prone to utilize natural carbon sources. Two consortia were introduced with and without combined lactic acid bacteria (CLAB) to rice straw for up to 60 days of ensiling, and their application notably decreased the levels of structural carbohydrates and pH values of rice straw silages. Treatments that combining microbial consortia and CLAB resulted in the highest levels of lactic acid, water soluble carbohydrates, mono- and disaccharides, and lignocellulose degradation, with PY + CLAB group yielding the highest bioethanol production. The microbial consortia identified herein exhibit great potential for degrading fibrous substrates, and their combination with CLAB provides a feasible way to efficiently use rice straw for bioethanol production.
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http://dx.doi.org/10.1016/j.biortech.2021.125507DOI Listing
July 2021

Synthesis of Succinimide Spiro-Fused Sultams from the Reaction of -(Phenylsulfonyl)acetamides with Maleimides via C(sp)-H Activation.

J Org Chem 2021 Jul 21. Epub 2021 Jul 21.

NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.

Presented herein is an effective preparation of succinimide spiro-fused sultams through the coupling reaction of -(phenylsulfonyl)acetamides with maleimides. It is deduced that this reaction should proceed through a cascade process including Rh(III)-catalyzed C(sp)-H bond cleavage of -(phenylsulfonyl)acetamide, maleimide double bond insertion into the C-Rh bond, β-hydride elimination, reductive elimination, and intramolecular aza-Michael addition. Notably, this cascade procedure features simultaneous annulation and spirocyclization through traceless fusion of the directing group into target product by using air as an economical oxidant to assist the regeneration of the active Rh(III) catalyst. This new method has several advantages including readily accessible starting materials with broad scope, significantly reduced synthetic steps, redox-neutral conditions, high atom-economy, and sustainability.
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http://dx.doi.org/10.1021/acs.joc.1c01048DOI Listing
July 2021

CELF2 is a candidate prognostic and immunotherapy biomarker in triple-negative breast cancer and lung squamous cell carcinoma: A pan-cancer analysis.

J Cell Mol Med 2021 Jul 19. Epub 2021 Jul 19.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

CUGBP Elav-like family member 2(CELF2) plays crucial roles in the development and activation of T cell. However, the impacts of CELF2 on tumour-infiltrating immune cells (TIICs) and clinical outcomes of tumours remain unclear. In this study, we found that elevated CELF2 expression was markedly correlated with prolonged survival in multiple tumours, particularly in breast and lung cancers. Notably, CELF2 only impacted the prognosis of triple-negative breast cancer (TNBC) with lymph node metastasis. Further investigation showed CELF2 expression was positively correlated with the infiltration abundance of dendritic cells (DCs), CD8+ T cells and neutrophils in breast invasive carcinoma (BRCA) and DCs in lung squamous cell carcinoma (LUSC). CELF2 also had strong correlations with markers of diverse TIICs such as T cells, tumour-associated macrophages and DCs in BRCA and LUSC. Importantly, CELF2 was significantly associated with plenty of immune checkpoint molecules (ICMs) and outperformed five prevalent biomarkers including PD-1, PD-L1, CTLA-4, CD8 and tumour mutation burden in predicting immunotherapeutic responses. Immunohistochemistry also revealed lower protein levels of CELF2 in TNBC and LUSC compared to normal tissues, and patients with high expression showed significantly prolonged prognosis. In conclusion, we demonstrated that increased CELF2 expression was closely related to better prognosis and superior TIIC infiltration and ICM expression, particularly in BRCA and LUSC. CELF2 also performed well in evaluating the immunotherapeutic efficacy, suggesting CELF2 might be a promising biomarker.
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http://dx.doi.org/10.1111/jcmm.16791DOI Listing
July 2021

Defining relative mutational difficulty to understand cancer formation.

Cell Discov 2020 Jul 21;6(1):48. Epub 2020 Jul 21.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.

Most mutations in human cancer are low-frequency missense mutations, whose functional status remains hard to predict. Here, we show that depending on the type of nucleotide change and the surrounding sequences, the tendency to generate each type of nucleotide mutations varies greatly, even by several hundred folds. Therefore, a cancer-promoting mutation may appear only in a small number of cancer cases, if the underlying nucleotide change is too difficult to generate. We propose a method that integrates both the original mutation counts and their relative mutational difficulty. Using this method, we can accurately predict the functionality of hundreds of low-frequency missense mutations in p53, PTEN, and INK4A. Many loss-of-function p53 mutations with dominant negative effects were identified, and the functional importance of several regions in p53 structure were highlighted by this analysis. Our study not only established relative mutational difficulties for different types of mutations in human cancer, but also showed that by incorporating such a parameter, we can bring new angles to understanding cancer formation.
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http://dx.doi.org/10.1038/s41421-020-0177-8DOI Listing
July 2020

[Retracted] MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2.

Int J Oncol 2021 Sep 19;59(3). Epub 2021 Jul 19.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the scratch-wound assay data shown in Fig. 3A and Transwell cell migration data shown in Figs. 3B and 6B were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to , the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. The Editor apologizes to the readership for any inconvenience caused. [the original article was published in 48: 541-550, 2016; DOI: 10.3892/ijo.2015.3267].
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http://dx.doi.org/10.3892/ijo.2021.5245DOI Listing
September 2021

Highly Efficient Hydroisomerization of -Tetrahydrodicyclopentadiene to -Tetrahydrodicyclopentadiene over Pt/HY.

ACS Omega 2021 Jul 30;6(27):17173-17182. Epub 2021 Jun 30.

Research Institute of Petroleum Processing, Sinopec, 18 Xueyuan Road, Haidian District, Beijing 100083, China.

The fast deactivation caused by serious formation of coke is a major challenge in catalytic isomerization of -tetrahydrodicyclopentadiene (-THDCPD) into -tetrahydrodicyclopentadiene (-THDCPD) over the HY zeolite. In order to suppress the coke formation for the isomerization process, the conventional HY zeolite was modified with Pt at 0.3 wt %. Then, the hydroisomerization of -THDCPD into -THDCPD was evaluated over a fixed-bed reactor. The catalytic stability of Pt/HY was greatly enhanced in comparison to that of the HY zeolite. The Pt/HY catalyst provided 97% -THDCPD conversion and 96% selectivity for -THDCPD without deactivation after 100 h. Moreover, the formation mechanism of coke on the HY zeolite during the isomerization process was proposed based on the results of the coke analysis. It was indicated that the coke was generated from the oligomerization and condensation of olefin species, which originated from the β-scission reaction or hydride transfer reaction of intermediates. The lower coke formation over Pt/HY was attributed to the lower amount of coke precursors, which could be hydrogenated by activated H over Pt sites. Therefore, Pt on Pt/HY and H were two crucial factors in efficiently enhancing the catalytic stability of the HY zeolite for this isomerization reaction.
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http://dx.doi.org/10.1021/acsomega.1c00212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280701PMC
July 2021

Plasma Level of Elabela in Patients with Coronary Heart Disease and Its Correlation with the Disease Classification.

Int Heart J 2021 Jul 17. Epub 2021 Jul 17.

Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University Health Science Center.

This study aimed to evaluate the concentration of plasma elabela (ELA) in patients with coronary heart disease (CHD) and its correlation with the disease classification.We enrolled 238 patients diagnosed by coronary angiography as CHD and 86 controls. The CHD group was divided into three subgroups: stable angina (SA), unstable angina (UAP), and acute myocardial infarction (AMI). The plasma levels of ELA were measured in all participants and compared among different groups. The relationship between ELA and CHD classification was analyzed.ELA levels were markedly higher by 10.71% in patients with CHD than in controls (P < 0.05). The concentration of ELA in UAP and AMI subgroups were higher than in controls and SA subgroup. The former difference was significant (P < 0.05), but the latter was not. In addition, the ELA concentration was not correlated with SYNTAX score, left ventricular ejection fraction, and other biochemical variables.The newfound hormone, ELA, significantly increased in patients with UAP and AMI. There is a tendency that ELA levels might be correlated with CHD classification, but not with lesion severity. ELA may play a role in acute coronary syndrome.
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http://dx.doi.org/10.1536/ihj.20-817DOI Listing
July 2021

Neck pain is the leading cause of disability burden in China: Findings from the Global Burden of Disease Study 2017.

Ann Transl Med 2021 May;9(9):777

National Centre for Chronic and Noncommunicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China.

Background: Neck pain (NP) is a common musculoskeletal problem; however, the prevalence and years lived with disability (YLD) of NP in China are still unclear. This study sought to estimate the age-, sex- and province-specific prevalence and YLD of NP in China.

Methods: Adopting the methodology framework and analytical strategies used in the Global Burden of Disease (GBD), Injuries, and Risk Factors Study (2017), the prevalence and YLD of NP in China were estimated by age, sex, year, and provinces/regions.

Results: In China, the age-standardized point prevalence rate of NP was 4,532.6 per 100,000 persons in 1990 and increased slightly to 4,634.4 per 100,000 persons in 2017. The prevalence of NP was 48.0 million in 1990 and rose dramatically to 87.3 million in 2017 (an increase of 82.0%). The age-standardized YLD rate of NP was 454.0 per 100,000 persons in 1990, and there was a slight increase to 465.6 per 100,000 persons in 2017. The all-age YLD of NP was 4.8 million in 1990 and rose to 8.8 million in 2017 (which represents an increase of 81.1%). In 1990, NP was the third leading cause of YLD in China, and in 2017, NP was the leading cause of disability burden.

Conclusions: This study estimated the prevalence and disability burden of NP in China. NP is currently the leading cause of disability burden in China; however, it is currently inadequately recognized and should receive further attention and be subject to further research.
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http://dx.doi.org/10.21037/atm-20-6868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246184PMC
May 2021

Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model.

Cancer Cell Int 2021 Jul 14;21(1):374. Epub 2021 Jul 14.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China.

Background: Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling pathway, the primary therapeutic direction focuses on identifying and designing HGF inhibitors, antagonists and other molecules to block the binding of HGF to C-MET, thereby limiting the abnormal state of other downstream genes.

Methods: This study focuses on the analysis of immune-related genes and corresponding immune functions that are significantly associated with the HGF/c-MET pathway using transcriptome data from 11 solid tumors.

Results: We systematically analyzed 11 different cancers, including expression correlation, immune infiltration, tumor diagnosis and survival prognosis from HGF/c-MET pathway and immune regulation, two biological mechanisms having received extensive attention in cancer analysis.

Conclusion: We found that the HGF/c-MET pathway affected the tumor microenvironment mainly by interfering with expression levels of other genes. Immune infiltration is another critical factor involved in changes to the tumor microenvironment. The downstream immune-related genes activated by the HGF/c-MET pathway regulate immune-related pathways, which in turn affect the degree of infiltration of immune cells. Immune infiltration is significantly associated with cancer development and prognosis.
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http://dx.doi.org/10.1186/s12935-021-02051-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278741PMC
July 2021

Effects of Tai Chi on health outcomes among community-dwelling adults with or at risk of metabolic syndrome: A systematic review.

Complement Ther Clin Pract 2021 Jul 10;44:101445. Epub 2021 Jul 10.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Objectives: This systematic review evaluated the effects of Tai Chi on health outcomes among community-dwelling adults with or at risk of metabolic syndrome (MetS).

Methods: Randomized controlled trials (RCTs) were searched in 10 databases. Data were statistically pooled for meta-analysis.

Results: Twenty RCTs were included. One study involved adults with MetS, and the other 19 studies involved adults with at least one risk factor for MetS. Tai Chi was found to reduce waist circumference and increase high-density lipoprotein cholesterol in obese adults. Tai Chi also reduces waist circumference, body mass index, blood glucose level, insulin resistance, and increases the quality of life (QoL) in adults with elevated blood glucose/type 2 diabetes (T2DM). Among participants with hypertension, Tai Chi improves blood pressure, lipid profiles, anxiety, depression, and physical QoL.

Conclusions: Tai Chi may be effective for enhancing the physiological and psychosocial wellbeing of community-dwelling adults at risk of MetS. Further RCTs are needed to examine its effects in adults with MetS and identify optimal regimes.
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http://dx.doi.org/10.1016/j.ctcp.2021.101445DOI Listing
July 2021

Application of Telemedicine Services Based on a Regional Telemedicine Platform in China From 2014 to 2020: Longitudinal Trend Analysis.

J Med Internet Res 2021 Jul 12;23(7):e28009. Epub 2021 Jul 12.

National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Telemedicine that combines information technology and health care augments the operational model of traditional medical services and brings new opportunities to the medical field. China promotes telemedicine with great efforts, and its practices in the deployment of telemedicine platforms and delivery of services have become important references for the research and development in this field.

Objective: Our work described in this paper focuses on a regional telemedicine platform that was built in 2014. We analyzed the system design scheme and remote consultations that were conducted via the system to understand the deployment and service delivery processes of a representative telemedicine platform in China.

Methods: We collected information on remote consultations conducted from 2015 to 2020 via the regional telemedicine platform that employs a centralized architectural system model. We used graphs and statistical methods to describe the changing trends of service volume of remote consultation, geographical and demographic distribution of patients, and waiting time and duration of consultations. The factors that affect consultation duration and patient referral were analyzed by multivariable linear regression models and binary logistic regression models, respectively. The attitudes toward telemedicine of 225 medical practitioners and 225 patients were collected using the snowball sampling method.

Results: The regional telemedicine platform covers all levels of medical institutions and hospitals in all 18 cities of Henan Province as well as some interprovince hospitals. From 2015 to 2020, 103,957 remote medical consultations were conducted via the platform with an annual increasing rate of 0.64%. A total of 86.64% (90,069/103,957) of medical institutions (as clients) that applied for remote consultations were tier 1 or 2 and from less-developed regions; 65.65% (68,243/103,945) of patients who applied for remote consultations were aged over 50 years. The numbers of consultations were high for departments focusing in the treatment of chronic diseases such as neurology, respiratory medicine, and oncology. The invited experts were mainly experienced doctors with senior professional titles. Year of consultation, tier of hospital, consultation department, and necessity of patient referral were the main factors affecting the duration of consultations. In surveys, we found that 60.4% (136/225) of medical practitioners and 53.8% (121/225) of patients had high satisfaction and believed that telemedicine is of vital importance for the treatment of illness.

Conclusions: The development of telemedicine in China shows a growing trend and provides great benefits especially to medical institutions located in less developed regions and senior citizens who have less mobility. Cases of remote consultations are mainly for chronic diseases. At present, the importance and necessity of telemedicine are well recognized by both patients and medical practitioners. However, the waiting time needs to be further reduced to improve the efficiency of remote medical services.
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http://dx.doi.org/10.2196/28009DOI Listing
July 2021

Comorbidity, lifestyle factors, and sexual satisfaction among Chinese cancer survivors.

Cancer Med 2021 Jul 13. Epub 2021 Jul 13.

Key Lab of Health Technology Assessment of National Health Commission and Key Lab of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China.

Objectives: This study aims to explore the prevalence of sexual satisfaction among Chinese cancer survivors, and explore the association of sexual satisfaction with comorbidity and lifestyle factors.

Methods: A cross-sectional study was performed among 3996 Chinese cancer survivors recruited at Shanghai Cancer Rehabilitation Club from March to April 2017. Data were collected through self-reported questionnaires. The questionnaire includes information about demographic, cancer characteristics, comorbidities, lifestyle factors, and sexual satisfaction. Sexual satisfaction was measured by a single-item scale. The distribution of sexual satisfaction among different demographic and cancer characteristics was compared using the chi-squared test. Logistic regression models were conducted to assess the effects of lifestyle factors, comorbidities on sexual satisfaction after adjustment for demographic and cancer characteristics.

Results: More than 40% of male and female cancer survivors reported no sexual satisfaction. Sexual satisfaction of cancer survivors is significantly associated with both the number and the type of comorbidities. Heart disease, musculoskeletal system disease, diabetes, and hyperlipidemia are the comorbidities significantly associated with sexual satisfaction of cancer survivors. Lifestyle factors other than smoking, including exercise or fitness, drinking alcohol, and eating fruits and vegetables are significantly correlated with sexual satisfaction. Besides, all of the above associations show gender differences. In addition, demographic characteristics include sex, age, marital status, living status, and average monthly income are also significantly associated with sexual satisfaction of cancer survivors.

Conclusion: Comorbidity and lifestyle factors are associated with sexual satisfaction of cancer survivors, and the associations show gender differences. Improving the lifestyles of cancer survivors, and controlling and reducing their comorbidities are important for improving their sexual satisfaction.
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http://dx.doi.org/10.1002/cam4.4118DOI Listing
July 2021

Technical Note: Performance evaluation of a small-animal PET/CT system based on NEMA NU 4-2008 standards.

Med Phys 2021 Jul 12. Epub 2021 Jul 12.

School of Medical Imaging, Xuzhou Medical University, Jiangsu, China.

Purpose: The Metis PET/CT is a self-developed, silicon photomultiplier (SiPM) detector-based, rodent PET/CT system. The objective of this study was to evaluate the performance of the system using the National Electrical Manufacturers Association (NEMA) NU 4-2008 standard protocol.

Methods: Energy resolution, spatial resolution, sensitivity, scatter fraction (SF), noise-equivalent count rate (NECR), and image quality (IQ) characteristics were measured. A micro Derenzo phantom experiment was performed to evaluate the spatial resolution using three-dimensional ordered-subsets expectation maximization (3D-OSEM) and maximum likelihood expectation maximization (MLEM) reconstructed images. In addition, the CT imaging agent Ioverol 350 was mixed with fluorine-18 ( F)-fluorodeoxyglucose (FDG) and then injected into the micro Derenzo phantom to evaluate the PET/CT imaging. In vivo PET/CT imaging studies were also conducted in a healthy mouse and rat using F-FDG.

Results: The mean energy resolution of the system was 15.3%. The tangential resolution was 0.82 mm full-width half-maximum (FWHM) at the center of the field of the view (FOV), and the radial and axial resolution were generally lower than 2.0 mm FWHM. The spatial resolution was significantly improved when using 3D-OSEM, especially the axial FWHM could be improved by up to about 57%. The system absolute sensitivity was 7.7% and 6.8% for an energy window of 200-750 and 350-750 keV respectively. The scatter fraction was 8.2% and 12.1% for the mouse- and rat-like phantom respectively. The peak NECR was 1343.72 kcps at 69 MBq and 640.32 kcps at 53 MBq for the mouse- and rat-like phantom respectively. The 1-mm fillable rod in the IQ phantom can be clearly observed. We can identify the 0.6-mm aperture of the micro Derenzo phantom image clearly using 3D-OSEM (10 subsets, 5 iterations). We also performed the fusion of the PET and CT images of the mouse and the brain imaging of the rat.

Conclusions: The results show that the system has the characteristics of high-resolution, high-sensitivity, and excellent IQ and is suitable for rodent imaging-based research.
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http://dx.doi.org/10.1002/mp.15088DOI Listing
July 2021

Using a high-throughput sequencing technology to evaluate the various forage source epiphytic microbiota and their effect on fermentation quality and microbial diversity of Napier grass.

Arch Microbiol 2021 Jul 9. Epub 2021 Jul 9.

Institute of Ensiling and Processing of Grass, College of Agro-Grassland Science, Nanjing Agricultural University, Weigang 1, Nanjing, 210095, China.

Napier grass (Pennisetum purpureum) is well-known due to its high biomass production. The epiphytic microbiota was prepared from Napier, alfalfa, and red clover grass and served as an inoculum. The chopped sterilized Napier grass was inoculated with reconstituted epiphytic microbiota, and treatments were designed as: distilled water (N0); Napier grass epiphytic microbiota (NP); alfalfa epiphytic microbiota (AL); and red clover epiphytic microbiota (RC). The results reveal that the reconstituted epiphytic microbiota bacteria efficiently adapted in Napier grass silage, improved fermentation, and produced lactic acid. The alfalfa-grass inoculum rapidly dropped pH and enhanced the lactic acid (LA) and the ratio of lactic acid-to-acetic acid (LA/AA) during the entire ensiling process. However, red clover attains high lactic acid, while Napier grass produces high acetic acid-type fermentation at terminal silage. After day 60 of ensiling, Lactobacillus proportion was higher in AL (85.45%), and RC (59.44%), inocula as compared with NP (36.41%), inoculum. The NP inoculum terminal silage was diverse than AL and RC inocula and dominated by Enterobacter (16.32%) and Enterobacteriaceae (10.16%) and also significantly (p < 0.05) higher in acetic acid. The present study concluded that AL and RC epiphytic microbiota successfully develop and more efficient than Napier grass microbiota. It is suggested that abundant microbiota isolate from alfala and red clover and develop more economical and efficient inocula for quality fermentation of Napier grass silage in practice.
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http://dx.doi.org/10.1007/s00203-021-02296-5DOI Listing
July 2021

Data mining of differentially expressed genes in epithelial ovarian carcinoma: Implications in precise medicine.

Curr Top Med Chem 2021 Jul 7. Epub 2021 Jul 7.

The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Mitochondrial Biomedical Research Institute, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Background: Epithelial ovarian carcinoma (EOC) is a ubiquitous gynecological malignancy with complicated pathogenesis. Genetic risk factors and pathways involved in the prognosis of this cancer are not yet understood completely. Determining genetic markers with diagnostic and prognostic values would pave the way for efficient management of cancer.

Objective: This study aimed to investigate the genes and the regulatory networks involved in the occurrence and prognosis of EOC through different bioinformatics analysis tools. In addition, recent advances in using bioinformatic analysis approach based on the genes and regulatory networks, particularly differentially expressed genes (DEGs), in improving the diagnosis and prognosis of EOC are discussed.

Methods: The gene expression profiles of GSE18520, GSE54388, and GSE27651 were downloaded from the Gene Expression Omnibus (GEO) database and further analyzed with different analyses in R language. Current literature on using bioinformatics based on DEGs and associated regulatory networks to improve the diagnosis and prognosis of EOC were reviewed.

Results: Analyses of the gene expression levels between the malignant tissue against normal tissue unveiled 163 DEGs. Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed on the target genes using clusterProfiler package, and Cytoscape package was employed to assess the protein interaction network of these genes. The protein-protein interaction network was analyzed using the CytoHubba plug-in to identify 20 hub genes. In addition, we analyzed the prognosis of the hub genes using the Kaplan-Meier survival analysis that revealed evident differences in the prognosis of 13 genes. The malignant tissues exhibited a differential expression of 12 genes against healthy tissues, as shown by Gene Expression Profiling Interactive Analysis (GEPIA) analysis.

Conclusion: Findings of this study revealed 12 genes to be significantly up-regulated, and the prognosis was significantly different, which could be employed to potentially target EOC in clinical practice.
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http://dx.doi.org/10.2174/1568026621666210708093649DOI Listing
July 2021

Constructing a Z-Scheme Heterojunction Photocatalyst of GaPO/α-MoC/GaO without Mingling Type-II Heterojunction for CO Reduction to CO.

ACS Appl Mater Interfaces 2021 Jul 7;13(28):33034-33044. Epub 2021 Jul 7.

School of Environmental Sciences and Engineering, Shaanxi University of Science & Technology, Xian, Shaanxi 710021, China.

Constructing Z-scheme heterojunction photocatalysts is a prevalent strategy to prolong the lifetime of photoinduced charge carriers without reducing their redox potentials. Nevertheless, these photocatalysts were usually mingled with type-II heterojunction, leading to a decrease in the redox potentials of photoinduced charge carriers. Herein, based on the absolute electronegativity of semiconductors, a Z-scheme heterojunction photocatalyst of GaPO/α-MoC/GaO was designed and successfully constructed, in which the formation of type-II heterojunction was prevented between GaPO and GaO. In the GaPO/α-MoC/GaO photocatalyst, the conduction band (CB) and valance band (VB) potentials and the Fermi level of GaO are higher than those of GaPO, respectively. Under irradiation, photoinduced electrons on the CB of GaPO migrate to the electron mediator α-MoC and subsequently recombine with the photoinduced holes of GaO, thereby retaining the photoinduced charge carriers with higher redox potentials. As a result, GaPO/α-MoC/GaO exhibits a 4-fold enhancement of activity for CO photoreduction, compared to GaO. Photocatalytic mechanism studies indicate that superoxide radicals might be an important intermediate for CO reduction to CO. The present work supplies a paradigm to construct a Z-scheme heterostructure without mingling type-II heterojunction via energy band engineering.
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http://dx.doi.org/10.1021/acsami.1c07757DOI Listing
July 2021

Near-Infrared Small Molecule as a Specific Fluorescent Probe for Ultrasensitive Recognition of Antiparallel Human Telomere G-Quadruplexes.

ACS Appl Mater Interfaces 2021 Jul 6;13(28):32743-32752. Epub 2021 Jul 6.

Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, People's Republic of China.

In the past 10 years, many fluorescent probes have been developed to recognize G-quadruplexes (G4s) since G4s play an important role in biological systems. However, the selectivity and sensitivity of existing probes for G4s limit their further applications. Herein, we design and synthesize a new probe (TOVJ) by introducing 9-vinyljulolidine into TO. The new probe exhibits almost no fluorescence in an aqueous solution. Upon interacting with G4s, especially the antiparallel G4s, the fluorescence intensity was greatly enhanced (maximum 2742-fold) with a large Stokes shift of 198 nm and the maximum emission peak at 694 nm (near-infrared region). TOVJ showed high sensitivity and selectivity to G4s over other DNA topologies (ssDNA/dsDNA), especially to antiparallel G4s. For antiparallel human telomere G4 detection, the limits of detection of Hum24 and 22AG Na were as low as 164 and 231 pM, respectively. This indicates that TOVJ is a highly sensitive fluorescence sensor that can be effectively used for antiparallel human telomere G4 detection. The result of live-cell imaging showed that TOVJ could enter live cells and locate in the mitochondria.
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http://dx.doi.org/10.1021/acsami.1c07101DOI Listing
July 2021

Toward Food Freshness Monitoring: Coordination Binding-Based Colorimetric Sensor Array for Sulfur-Containing Amino Acids.

Front Chem 2021 17;9:685783. Epub 2021 Jun 17.

Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.

Herein, a self-assembled colorimetric chemosensor array composed of off-the-shelf catechol dyes and a metal ion (i.e., Zn) has been used for the sulfur-containing amino acids (SCAAs; i.e., glutathione, glutathione disulfide, L-cysteine, DL-homocysteine, and L-cystine). The coordination binding-based chemosensor array (CBSA) fabricated by a competitive assay among SCAAs, Zn ions, and catechol dyes [i.e., pyrocatechol violet (PV), bromopyrogallol red (BPR), pyrogallol red (PR), and alizarin red S (ARS)] yielded fingerprint-like colorimetric changes. We succeeded in the qualification of SCAAs based on pattern recognition [i.e., a linear discrimination analysis (LDA)] with 100% correct classification accuracy. The semiquantification of reduced/oxidized forms of SCAAs was also performed based on LDA. Furthermore, we carried out a spike test of glutathione in food samples using the proposed chemosensor array with regression analysis. It is worth mentioning that we achieved a 91-110% recovery rate in real sample tests, which confirmed the accuracy of the constructed model. Thus, this study represents a step forward in assessing food freshness based on supramolecular analytical methods.
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http://dx.doi.org/10.3389/fchem.2021.685783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248799PMC
June 2021

Tetrathiafulvalene-based covalent organic frameworks for ultrahigh iodine capture.

Chem Sci 2021 May 13;12(24):8452-8457. Epub 2021 May 13.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University Changchun 130012 P. R. China

To safeguard the development of nuclear energy, practical techniques for capture and storage of radioiodine are of critical importance but remain a significant challenge. Here we report the synergistic effect of physical and chemical adsorption of iodine in tetrathiafulvalene-based covalent organic frameworks (COFs), which can markedly improve both iodine adsorption capacity and adsorption kinetics due to their strong interaction. These functionalized architectures are designed to have high specific surface areas (up to 2359 m g) for efficient physisorption of iodine, and abundant tetrathiafulvalene functional groups for strong chemisorption of iodine. We demonstrate that these frameworks achieve excellent iodine adsorption capacity (up to 8.19 g g), which is much higher than those of other materials reported so far, including silver-doped adsorbents, inorganic porous materials, metal-organic frameworks, porous organic frameworks, and other COFs. Furthermore, a combined theoretical and experimental study, including DFT calculations, electron paramagnetic resonance spectroscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy, reveals the strong chemical interaction between iodine and the frameworks of the materials. Our study thus opens an avenue to construct functional COFs for a critical environment-related application.
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http://dx.doi.org/10.1039/d1sc01742jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221174PMC
May 2021

The Sequencing-Based Mapping Method for Effectively Cloning Plant Mutated Genes.

Int J Mol Sci 2021 06 9;22(12). Epub 2021 Jun 9.

State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430072, China.

A forward genetic approach is a powerful tool for identifying the genes underlying the phenotypes of interest. However, the conventional map-based cloning method is lengthy, requires a large mapping population and confirmation of many candidate genes in a broad genetic region to clone the causal variant. The whole-genome sequencing method clones the variants with a certain failure probability for multiple reasons, especially for heterozygotes, and could not be used to clone the mutation of epigenetic modifications. Here, we applied the highly complementary characteristics of these two methods and developed a sequencing-based mapping method (SBM) for identifying the location of plant variants effectively with a small population and low cost, which is very user-friendly for most popular laboratories. This method used the whole-genome sequencing data of two pooled populations to screen out enough markers. These markers were used to identify and narrow the candidate region by analyzing the marker-indexes and recombinants. Finally, the possible mutational sites were identified using the whole-genome sequencing data and verified in individual mutants. To elaborate the new method, we displayed the cloned processes in one heterozygous mutant and two rice homozygous mutants. Thus, the sequencing-based mapping method could clone effectively different types of plant mutations and was a powerful tool for studying the functions of plant genes in the species with known genomic sequences.
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http://dx.doi.org/10.3390/ijms22126224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226582PMC
June 2021

A Wide-Range Stiffness-Tunable Soft Actuator Inspired by Deep-Sea Glass Sponges.

Soft Robot 2021 Jun 29. Epub 2021 Jun 29.

State Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, China.

Achieving both high compliance and stiffness is a key issue in stiffness-tunable soft robots. A wide-range variable-stiffness method keeping pure soft characteristic is proposed by bioinspired design of deep-sea glass sponges adopting thermoplastic starch. The stiffness-tunable mechanism is designed through force analysis and optimization of its bionic cellular structure. It is fabricated with load-weight ratio exceeding 470. Then, a wide-range stiffness-tunable omnidirectional-bending soft actuator (WOSA) is realized, and the bending stiffness model is established. Comparative experiments of stiffness and deformation are conducted on WOSA and a pure soft actuator (PSA) with the same size. Results show that the WOSA can get 92.3 times initial bending and 70.8 times torsional stiffness variation range, of which the flexibility is even better than PSA. A gripper assembled by three WOSAs is verified through stiffness adjustment that it can grasp different weight fragile, soft items from the unshelled fresh egg, boiled egg yolk to grapes. It can even lift a dumbbell weighting 3.32 kg. Finally, a manipulator demonstrated its potential in future minimally invasive surgical applications due to its wide stiffness range and large deformation capacity.
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http://dx.doi.org/10.1089/soro.2020.0163DOI Listing
June 2021

The measurement of ocular axial length in normal human eyes based on an improved Twyman-Green interferometer.

J Biophotonics 2021 Jun 22:e202100021. Epub 2021 Jun 22.

Institute of Biomedical Optics and Optometry, Key Lab of Medical Optical Technology and Instruments, Ministry of Education, University of Shanghai for Science and Technology, Shanghai, China.

In order to meet the demands of myopia prevention, as well as the increasing needs of measurement for refractive and cataract operations in China, a new axial length (AL) measurement system combining an improved Twyman-Green interferometer with digital signal processing has been established. The ALs of 33 eyes of different optical refractive subjects (-8.50 ~ 0.50 D) were measured with the New AL and intraocular lens (IOL) master. The repeatability of measurements with the New AL was assessed using coefficient of variation (CoV) and intra-group correlation coefficient (ICC). Comparison, correlation, linear regression and agreement of AL between devices were analyzed. There was good repeatability (CoV = 0.0617%, ICC = 0.9999) with the New AL and great agreement has been obtained with both devices. These show that the New AL is capable of providing precise AL values over the normal AL range compared to the IOL master, and indicate that the New AL developed can be used for routine clinical AL measurements.
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http://dx.doi.org/10.1002/jbio.202100021DOI Listing
June 2021

N-acetylcysteine ameliorate cytotoxic injury in piglets sertoli cells induced by zearalenone and deoxynivalenol.

Environ Sci Pollut Res Int 2021 Jun 22. Epub 2021 Jun 22.

College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China.

Zearalenone (ZEA) and Deoxynivalenol (DON) are two mycotoxins highly detected in agricultural products and feed. Both mycotoxins produce reproductive toxicity and pose a serious threat to human and animal health, among which pigs are the most sensitive animals. Sertoli cells (SCs) play an important role in spermatogenesis; however, the combined toxicity of ZEA and DON and the screening of effective protective agents remains to be determined. By studying the effects of N-acetylcysteine (NAC) on the cells exposed to 20 μM of ZEA and 0.6 μM of DON, we explored the protective mechanism of NAC (4 mM) on the cytotoxic injury of piglets SCs induced by both mycotoxins. The results showed that the combination of ZEA and DON destroy organelles and SCs structures, NAC significantly alleviates the damage caused by ZEA and DON. NAC also significantly increased the expression and distribution of zonula occludens 1 (ZO-1), decreased the relative mRNA and protein expression levels of Bax, Bid, caspase-3, and caspase-9, and increased Bcl-2 expression level and inhibited the decrease of mitochondrial membrane potential. Further, NAC also eases the cell cycle arrest and oxidative stress caused by ZEA and DON. In summary, our results show that NAC could alleviate SCs injury via reducing the oxidative damage and apoptosis caused by ZEA and DON.
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http://dx.doi.org/10.1007/s11356-021-14052-9DOI Listing
June 2021

Innentitelbild: Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies (Angew. Chem. 23/2021).

Angew Chem Weinheim Bergstr Ger 2021 Jun 26;133(23):12718. Epub 2021 Apr 26.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University Shanghai 200240 China.

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http://dx.doi.org/10.1002/ange.202104989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206910PMC
June 2021
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