Publications by authors named "Jie Yin"

696 Publications

Synthesis, structure, mobility and memristor properties of tetragonal CHNHPbBr perovskite single crystals.

Dalton Trans 2021 Jul 20. Epub 2021 Jul 20.

School of Chemistry and Chemical Engineering; College of Materials Science and Engineering; Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage; Liaocheng University, China.

The structure, mobility and memristor properties of tetragonal CH3NH3PbBr3 single crystals (T-MAPbBr3 SC) are rarely reported. In this study, we synthesized T-MAPbBr3 SC with the P4/mmm (123) space group by the growing, dropping and growing (GDG) crystal seed method. A CH3NH3+ cation is a disordered state in T-MAPbBr3 SC. The mobility values of T-MAPbBr3 SC under light and dark conditions are 464.28 and -1685.3 cm2 V-1 s-1, respectively. The carrier types under light and dark conditions are holes and electrons, respectively. The memristor based on T-MAPbBr3 SC has a wide and low operating voltage window (0-0.9 V). The high and low resistances of the memristor based on T-MAPbBr3 SC achieve values of 41 and 0.35 GΩ, respectively. The values of high and low resistances are relatively stable for 100 cycles. Thus, the memristor device based on T-MAPbBr3 SC has good applications in the field of memristors.
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http://dx.doi.org/10.1039/d1dt00492aDOI Listing
July 2021

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators.

Microbiome 2021 07 20;9(1):162. Epub 2021 Jul 20.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract.
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http://dx.doi.org/10.1186/s40168-021-01093-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293578PMC
July 2021

Low-protein diets supplemented with glutamic acid or aspartic acid ameliorate intestinal damage in weaned piglets challenged with hydrogen peroxide.

Anim Nutr 2021 Jun 10;7(2):356-364. Epub 2021 Mar 10.

College of Animal Science and Technology, Hunan Agriculture University; Hunan Co-Innovation Center of Animal Production Safety, Changsha, 410128, China.

Glutamic acid (Glu) and aspartic acid (Asp) are acidic amino acids with regulatory roles in nutrition, energy metabolism, and oxidative stress. This study aimed to evaluate the effects of low-protein diets supplemented with Glu and Asp on the intestinal barrier function and energy metabolism in weaned piglets challenged with hydrogen peroxide (HO). Forty piglets were randomly divided into 5 groups: NC, PC, PGA, PG, and PA ( = 8 for each group). Pigs in the NC and PC groups were fed a low-protein diet, while pigs in the PGA, PG, or PA groups were fed the low-protein diet supplemented with 2.0% Glu +1.0% Asp, 2.0% Glu, or 1.0% Asp, respectively. On day 8 and 11, pigs in the NC group were intraperitoneally injected with saline (1 mL/kg BW), while pigs in the other groups were intraperitoneally administered 10% HO (1 mL/kg BW). On day 14, all pigs were sacrificed to collect jejunum and ileum following the blood sample collection in the morning. Notably, low-protein diets supplemented with Glu or Asp ameliorated the intestinal oxidative stress response in HO-challenged piglets by decreasing intestinal expression of genes ( < 0.05) (e.g., manganese superoxide dismutase [], glutathione peroxidase [], and ) encoding oxidative stress-associated proteins, reducing the serum concentration of diamine oxidase ( < 0.05), and inhibiting apoptosis of the intestinal epithelium. Glu and Asp supplementation attenuated the upregulated expression of energy metabolism-associated genes (such as hexokinase and carnitine palmitoyltransferase-1) and the HO-induced activation of acetyl-coenzyme A carboxylase (ACC) in the jejunum and adenosine monophosphate-activated protein kinase-acetyl-ACC signaling in the ileum. Dietary Glu and Asp also ameliorated intestinal barrier damage as indicated by restored intestinal histology and morphology. In conclusion, low-protein diets supplemented with Glu and Asp protected against oxidative stress-induced intestinal dysfunction in piglets, suggesting that this approach could be used as a nutritional regulatory protectant against oxidative stress.
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http://dx.doi.org/10.1016/j.aninu.2020.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245806PMC
June 2021

Physiological function and application of dietary fiber in pig nutrition: A review.

Anim Nutr 2021 Jun 17;7(2):259-267. Epub 2021 Apr 17.

College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.

Dietary fiber (DF), divided into soluble dietary fiber (SDF) and insoluble dietary fiber (IDF), has attracted increasing attention in the field of pig nutrition. Although DF reduces nutrient digestibility and inhibits energy deposition in most cases, fiber-rich feeds have been widely used in pig diets. This is not only because of lower feed costs, but also from the continuous discovery about the nutritional value of DF, mainly including the improvement of piglet intestinal health and sow reproductive performance. The addition timing has also been further considered, which potentially enables the nutritional value of DF to be accurately used in applicable pig models. Furthermore, fiber degrading enzymes have been shown to alleviate the anti-nutritional effects of DF and have ensured the improvement effect of fiber on intestinal health in young piglet models. However, the regulatory effect of fiber on pork quality is still unclear, which requires consideration of the wide range of fiber sources and the complexity of the basic diet composition, as well as the impact of pig breeds. Taken together, future research needs to gain more insight into the combined effects of SDF and IDF, processing methods, and addition timing to improve the nutritional value of DF, and further explore the physiological functions and regulatory mechanisms of DF fermentation products short-chain fatty acids in pigs.
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http://dx.doi.org/10.1016/j.aninu.2020.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245790PMC
June 2021

A miR-212-3p/SLC6A1 Regulatory Sub-Network for the Prognosis of Hepatocellular Carcinoma.

Cancer Manag Res 2021 28;13:5063-5075. Epub 2021 Jun 28.

Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, 832002, People's Republic of China.

Introduction: Hepatocellular carcinoma (HCC) is a liver cancer with a poor prognosis. Owing to the complexity and limited pathogenic mechanism research on HCC, the molecular targeted therapy has been hindered.

Methods: In this study, we categorized transcriptome data into low-Myc and high-Myc expression groups in 365 HCC samples, screened the differentially expressed RNAs, including 441 DE-lncRNAs, 99 DE-miRNAs and 612 DE-mRNAs, constructed a lncRNA-miRNA-mRNA regulatory network, and selected a hub triple regulatory network through cytoHubba analysis. Through Gene ontology and KEGG pathway, a hub regulatory network was particularly enriched in the "Wnt signaling pathway" and "Cytochrome P450-arranged by substrate type" by Metascape. The prognostic genes in the hub regulatory network were evaluated by the RNA expression analysis, Kaplan-Meier (KM) survival analysis, and correlation analysis.

Results: The results showed that miR-212-3p/SLC6A1 axis was a potential prognostic model for HCC. Furthermore, IHC analysis showed down-regulated expression of SLC6A1 in HCC tissues and Alb-Cre;Myc mouse liver cancer tissues. The genetics and epigenetic analysis indicated that SLC6A1 expression was negatively correlated with DNA methylation. Immune infiltration analysis showed a negative relation between SLC6A1 and T cell exhaustion/monocyte in liver cancer tissues.

Conclusion: In summary, the study revealed that miR-212-3p/SLC6A1 axis could serve as a crucial therapeutic target for HCC.
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http://dx.doi.org/10.2147/CMAR.S308986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254378PMC
June 2021

Revisiting an Expression Dataset of Discordant Inflammatory Bowel Disease Twin Pairs Using a Mutation Burden Test Reveals as a Novel Marker.

Front Genet 2021 15;12:680125. Epub 2021 Jun 15.

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

The aim of this study was to investigate the expression features of discordant inflammatory bowel disease (IBD) twin pairs to identify novel molecular features and markers. We collected an expression dataset of discordant twin pairs with ulcerative colitis and performed integrative analysis to identify the genetic-independent expression features. Through deconvolution of the immune cell populations and tissue expression specificity, we refined the candidate genes for susceptibility to ulcerative colitis. We found that dysregulated immune systems and NOD-related pathways were enriched in the expression network of the discordant IBD twin pairs. Among the identified factors were significantly increased proportions of immune cells, including megakaryocytes, neutrophils, natural killer T cells, and lymphatic endothelial cells. The differentially expressed genes were significantly enriched in a gene set associated with cortical and medullary thymocytes. Finally, by combining these expression features with genetic resources, we identified some candidate genes with potential to serve as novel markers of ulcerative colitis, such as CYP2C18. Ulcerative colitis is a subtype of inflammatory bowel disease and a polygenic disorder. Through integrative analysis, we identified some genes, such as CYP2C18, that are involved in the pathogenesis of IBD as well as some candidate therapeutic targets, such as LOXL2.
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http://dx.doi.org/10.3389/fgene.2021.680125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239360PMC
June 2021

Long non-coding RNA RP11-81H3.2 suppresses apoptosis by targeting microRNA-1539/COL2A1 in human nucleus pulposus cells.

Exp Ther Med 2021 Aug 16;22(2):884. Epub 2021 Jun 16.

Department of Orthopaedics, 987 Hospital of Peoples Liberation Army of China Joint Logistics Support Force, Baoji, Shaanxi 721004, P.R. China.

Intervertebral disk degeneration (IDD) is a severe health problem that results in lower back pain and disability. Previous evidence has indicated that excessive apoptosis of nucleus pulposus (NP) cell is involved in the occurrence and development of IDD. However, the underlying mechanisms regulating NP cell apoptosis are unclear. The present study aimed to investigate the function of a novel long non-coding RNA RP11-81H3.2 in modulating NP cell apoptosis and the potential underlying mechanisms. The results demonstrated that the RP11-81H3.2 expression levels were significantly decreased in NP tissues from patients with IDD compared with those from healthy controls, and that lower expression levels were associated with higher-grade disk degeneration. Functionally, RP11-81H3.2 silencing promoted apoptosis and decreased the viability of NP cells derived from tissue samples of patients with IDD, whereas RP11-81H3.2 overexpression induced opposite effects. Bioinformatics analysis, luciferase assays and reverse transcription-quantitative PCR revealed that microRNA (miR)-1539 was a direct target of RP11-81H3.2. A mechanistic analysis demonstrated that RP11-81H3.2 functioned as an RNA sink to downregulate miR-1539, which led to the upregulation of collagen type 2 α 1 chain (COL2A1), a target of miR-1539. Collectively, the present results suggested that lower RP11-81H3.2 expression levels were associated with higher-grade IDD, and that RP11-81H3.2 inhibited NP cell apoptosis by decreasing the levels of miR-1539 to increase COL2A1 expression levels. The present study identified a beneficial role of RP11-81H3.2 against NP cell apoptosis.
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http://dx.doi.org/10.3892/etm.2021.10316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237274PMC
August 2021

Characterization and epitope prediction of phosphopyruvate hydratase from Penaeus monodon (black tiger shrimp).

J Food Sci 2021 Jun 30. Epub 2021 Jun 30.

Guangdong Women and Children Hospital, Guangzhou, China.

Shellfish allergies constitute an important cause of food-induced anaphylactic reactions, which pose challenges to food safety and human health worldwide. In the present study, the specific IgE (sIgE) binding characteristics of different shrimp proteins of black tiger shrimp (Penaeus monodon) to the sera of eight shrimp-allergic patients from China were studied by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and nanoliquid chromatography time-of-flight mass spectrometry. According to the PLGS scores (>2000) and the sequence coverage (>40%), eight proteins with sIgE binding activity were identified, including myosin heavy chain type 1 (K4Q4N8), hemocyanin (G1AP69 and Q95V28), phosphopyruvate hydratase (O96656), arginine kinase (C7E3T4), tropomyosin (A1KYZ2), sarcoplasmic calcium binding protein (H7CHW2) and glyceraldehyde-3-phosphate dehydrogenase (A0A097BQP2). Among these eight proteins, phosphopyruvate hydratase was a prevalent IgE-binding protein among these Chinese patients with binding observed in 100% of sera. Moreover, 13 peptides were predicted as epitopes of phosphopyruvate hydratase. These new details help us to understand the crustacean IgE-binding proteins especially Penaeus monodon IgE-binding proteins, that would cause allergic reaction to Chinese patients. And our findings may provide essential information to improve allergy prevention and clinical treatment to shrimp allergy in China. PRACTICAL APPLICATION: This research may have diagnostic and therapeutic value for shrimp allergies in China.
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http://dx.doi.org/10.1111/1750-3841.15819DOI Listing
June 2021

Clinical significance of interventional therapeutic bronchoscopy combined with bronchial arterial embolization in the treatment of hypervascular primary airway tumors in children.

Pediatr Investig 2021 Jun 18;5(2):130-135. Epub 2021 Jun 18.

The Second Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.

Importance: Pediatric hypervascular primary airway tumors are progressive, fatal lesions with a low incidence, and the disease is often more serious than that in adults.

Objective: To evaluate the clinical efficacy and safety of interventional therapeutic bronchoscopy combined with conservative treatment and bronchial arterial embolization in children with primary airway tumors.

Methods: We retrospectively analyzed the clinical data of four pediatric patients with hypervascular primary airway tumor between 2017 and 2019 at Beijing Children's Hospital.

Results: Two patients were low-grade bronchial mucoepidermoid carcinoma, one patient was pleomorphic adenoma, and one was bronchial leiomyoma. Interventional therapeutic bronchoscopy combined with bronchial arterial embolization was used for treatment (all four patients received general anesthesia). The tumors were safely resected in all patients via interventional bronchoscopy. There were no severe complications related to the procedures. All patients were followed up for 5-12 months, and one low-grade bronchial mucoepidermoid carcinoma recurred.

Interpretation: Interventional therapeutic bronchoscopy combined with bronchial arterial embolization appears to be a safe and efficient therapeutic method associated with less trauma and fewer complications, including no serious adverse events, in children with hypervascular primary airway tumors without bronchus wall infiltration.
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http://dx.doi.org/10.1002/ped4.12256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212720PMC
June 2021

Author Correction: Nanoscale bubble domains with polar topologies in bulk ferroelectrics.

Nat Commun 2021 Jun 24;12(1):4035. Epub 2021 Jun 24.

Department of Materials Science and Engineering, National University of Singapore, Singapore City, Singapore.

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http://dx.doi.org/10.1038/s41467-021-24356-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225867PMC
June 2021

Current indications for endoscopic submucosal dissection of early gastric cancer.

World J Gastrointest Oncol 2021 Jun;13(6):560-573

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

The development of endoscopic treatment technology has further promoted the minimally invasive treatment of early gastric cancer (EGC). Endoscopic treatment has achieved better therapeutic effects in terms of safety and prognosis and is the preferred treatment method for patients who meet the indications for endoscopic treatment. However, the consequent problem is that some patients receiving endoscopic treatment may undergo non-curative resection, and the principle of follow-up management for non-curative resection patients deserves further attention. In addition, there are still debates on how to improve the accuracy of clinical staging, select a reasonable treatment method for patients who meet the expanded indications for endoscopic treatment, manage patients with positive endoscopic surgical margins, conduct research on function-preserving surgery, and manage the treatment of EGC under the current situation in China. Consequently, we aim to review current indications for endoscopic submucosal dissection of EGC in order to better inform treatment options.
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http://dx.doi.org/10.4251/wjgo.v13.i6.560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204359PMC
June 2021

Effects of bovine cancellous bone powder/poly amino acid composites on cellular behaviors and osteogenic performances.

Biomed Mater 2021 Jul 6;16(5). Epub 2021 Jul 6.

School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, People's Republic of China.

Xenogeneic bone has good biological activity, but eliminating immunogenicity, while retaining osteogenic abilities, is a challenge. By combining xenogeneic bone with poly amino acid (PAA) that has an amide bond structure, a new type of composite conforming to bionics and low immunogenicity may be obtained. In this study, according to the principles of component bionics, three composites of delipidized cancellous bone powder (DCBP) and PAA were designed and obtained by anpolycondensation method, an extrusion molding (EM) method, and a solution-blend method. The three composites were all macroscopically uniform, non-cytotoxic, and demonstrated low immunogenicity by effective removal of residual antigens during preparation. Compared with PAA, mouse bone marrow mesenchymal stem cells (BMSCs) on the surfaces of three composites showed different cellular morphologies. The effects of different preparation methods and cellular morphology on cellular differentiation were confirmed by alkaline phosphatase activity, calcium nodule formation and the expression levels of osteogenic differentiation-related genes (bone morphogenetic protein 2, runt-related transcription factor 2, osteopontin and osteocalcin). Among these composites, DCBP/PAA EM showed best cell proliferation and osteogenic differentiation, and possessed greater bone formation than PAA in a rabbit femoral condyle study. This study may provide a new method for preparing bioactive bone repair materials with low immunogenicity and superior ability to stimulate differentiation of BMSCsand osteogenesis. DCBP/PAA EM might be a promising bone repair material for bone defect treatment.
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http://dx.doi.org/10.1088/1748-605X/ac0d94DOI Listing
July 2021

Effect of the event strength of the coronavirus disease (COVID-19) on potential online organic agricultural product consumption and rural health tourism opportunities.

MDE Manage Decis Econ 2021 Jul 27;42(5):1156-1171. Epub 2021 Apr 27.

College of Tourism Huaqiao University Quanzhou China.

The coronavirus disease (COVID-19) outbreak has raised consumer concerns about health. By employing 306 online questionnaires, we identify COVID-19's effect on online organic agriculture product consumption and rural health tourism intention based on stimulus-organism-response theory and event system theory by incorporating risk information disclosure of COVID-19 as the moderating variable and health consciousness and risk perception as the mediating variables. These findings suggest that considering the impact of COVID-19 can help focus the production and online sales of organic agricultural products, the establishment and improvement of rural health facilities, and the marketing of rural health tourism.
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http://dx.doi.org/10.1002/mde.3298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207050PMC
July 2021

Microstructural design for mechanical-optical multifunctionality in the exoskeleton of the flower beetle .

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061;

Biological systems have a remarkable capability of synthesizing multifunctional materials that are adapted for specific physiological and ecological needs. When exploring structure-function relationships related to multifunctionality in nature, it can be a challenging task to address performance synergies, trade-offs, and the relative importance of different functions in biological materials, which, in turn, can hinder our ability to successfully develop their synthetic bioinspired counterparts. Here, we investigate such relationships between the mechanical and optical properties in a multifunctional biological material found in the highly protective yet conspicuously colored exoskeleton of the flower beetle, Combining experimental, computational, and theoretical approaches, we demonstrate that a micropillar-reinforced photonic multilayer in the beetle's exoskeleton simultaneously enhances mechanical robustness and optical appearance, giving rise to optical damage tolerance. Compared with plain multilayer structures, stiffer vertical micropillars increase stiffness and elastic recovery, restrain the formation of shear bands, and enhance delamination resistance. The micropillars also scatter the reflected light at larger polar angles, enhancing the first optical diffraction order, which makes the reflected color visible from a wider range of viewing angles. The synergistic effect of the improved angular reflectivity and damage localization capability contributes to the optical damage tolerance. Our systematic structural analysis of 's different color polymorphs and parametric optical and mechanical modeling further suggest that the beetle's microarchitecture is optimized toward maximizing the first-order optical diffraction rather than its mechanical stiffness. These findings shed light on material-level design strategies utilized in biological systems for achieving multifunctionality and could thus inform bioinspired material innovations.
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http://dx.doi.org/10.1073/pnas.2101017118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237622PMC
June 2021

Nanoscale bubble domains with polar topologies in bulk ferroelectrics.

Nat Commun 2021 Jun 15;12(1):3632. Epub 2021 Jun 15.

Department of Materials Science and Engineering, National University of Singapore, Singapore City, Singapore.

Multitudinous topological configurations spawn oases of many physical properties and phenomena in condensed-matter physics. Nano-sized ferroelectric bubble domains with various polar topologies (e.g., vortices, skyrmions) achieved in ferroelectric films present great potential for valuable physical properties. However, experimentally manipulating bubble domains has remained elusive especially in the bulk form. Here, in any bulk material, we achieve self-confined bubble domains with multiple polar topologies in bulk BiNaTiO ferroelectrics, especially skyrmions, as validated by direct Z-contrast imaging. This phenomenon is driven by the interplay of bulk, elastic and electrostatic energies of coexisting modulated phases with strong and weak spontaneous polarizations. We demonstrate reversable and tip-voltage magnitude/time-dependent donut-like domain morphology evolution towards continuously and reversibly modulated high-density nonvolatile ferroelectric memories.
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http://dx.doi.org/10.1038/s41467-021-23863-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206216PMC
June 2021

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.

Nat Commun 2021 06 14;12(1):3595. Epub 2021 Jun 14.

Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA.

Cataract is the leading cause of blindness among the elderly worldwide and cataract surgery is one of the most common operations performed in the United States. As the genetic etiology of cataract formation remains unclear, we conducted a multiethnic genome-wide association meta-analysis, combining results from the GERA and UK Biobank cohorts, and tested for replication in the 23andMe research cohort. We report 54 genome-wide significant loci, 37 of which were novel. Sex-stratified analyses identified CASP7 as an additional novel locus specific to women. We show that genes within or near 80% of the cataract-associated loci are significantly expressed and/or enriched-expressed in the mouse lens across various spatiotemporal stages as per iSyTE analysis. Furthermore, iSyTE shows 32 candidate genes in the associated loci have altered gene expression in 9 different gene perturbation mouse models of lens defects/cataract, suggesting their relevance to lens biology. Our work provides further insight into the complex genetic architecture of cataract susceptibility.
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http://dx.doi.org/10.1038/s41467-021-23873-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203611PMC
June 2021

ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.

Front Pharmacol 2021 28;12:669730. Epub 2021 May 28.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Macrophage polarization and phenotypic switching of smooth muscle cells (SMCs) are multi-faceted events dominating atherosclerosis (AS) progression. TGF-β was proved to been one of the bridge on the crosstalk between macrophage and SMC. ShenLian (SL) was extracted from a potent anti-atherosclerotic formula. However, its exact mechanism rebalancing inflammatory microenvironment of AS remain largely unknown. Within the entirety of macrophage and SMC, this study investigated the pharmacological effects of SL on stabilizing atherosclerotic plaques. The main components of SL were examined by high performance liquid chromatography. Co-culture and conditioned medium models of macrophage/SMC interactions were designed to identify the relationship between macrophage polarization and switching of SMC phenotypes. Flow cytometry, immunofluorescent staining, RT-PCR, western blotting, and ELISA were used to determine the expression of molecules relating to AS progression. An atherosclerosis animal model, established by placing a perivascular collar on the right common carotid artery in ApoE mice, was used to investigate whether TGF-β is the key molecular mediator of SL in crosstalk between macrophage and SMC. Plaque size was defined by nuclear magnetic resonance imaging. Key markers related to phenotypic transformation of macrophage and SMC were determined by immunohistochemical staining. Results revealed that, accompanied by rebalanced M2 macrophage polarization, SL supported SMC phenotypic transformation and functionally reconstruct the ECM of plaques specifically in macrophage-SMC co-cultural model. Molecularly, such activity of SL closely related to the activation of STAT3/SOCS3 pathway. Furthermore, in co-culture system, up-regulation of α-SMA induced by SL could neutralized by 1D11, a TGF-β neutralizing antibody, indicating that SL mediated Macrophage-SMC communication by enhancing TGF-β. In the AS model constructed by ApoE mice, effects of SL on phenotypic transformation of macrophage and SMC has been well verified. Specific blocking of TGF-β largely attenuated the aforementioned effects of SL. Our findings highlighted that TGF-β might be the responsive factor of SL within macrophage and SMC communication. This study revealed that crosstalk between macrophage and SMC forms a holistic entirety promoting atherosclerotic plaque stability.
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http://dx.doi.org/10.3389/fphar.2021.669730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193129PMC
May 2021

Enzyme-Treated Soybean Meal Replacing Extruded Full-Fat Soybean Affects Nitrogen Digestibility, Cecal Fermentation Characteristics and Bacterial Community of Newly Weaned Piglets.

Front Vet Sci 2021 20;8:639039. Epub 2021 May 20.

College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

The study investigated the impact of soybean protein from different processing on the performance, dietary nitrogen digestibility, cecal fermentation characteristics, and bacterial community in newly weaned piglets. The piglets were allocated to two dietary treatment and fed with the extruded full-fat soybean diet (EFS group) and enzyme-treated soybean meal diet (ESBM group), respectively. The piglets in ESBM group showed greater nitrogen digestibility and feed efficiency, and lower diarrhea rate in comparison to piglets in EFS group ( < 0.05). Cecal samples from piglets in ESBM group contained greater concentration of acetate, propionate and total SCFAs ( < 0.05), and lower contents of isobutyrate, isovalerate, total BCFAs, NH-N and putrescine ( < 0.05) than cecal samples from piglets in the EFS group. The cecal samples from piglets in ESBM group contained greater abundances of g_, g_, g_, and g_ than the cecal sample from piglets in the EFS group, which could promote to protect intestinal health. In summary, enzyme-treated soybean meal may enhance the growth performance of weaned piglets increasing the dietary nitrogen digestibility, preventing protein fermentation in the hindgut, which shed light on the mechanism in regulating gut health of dietary protein.
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http://dx.doi.org/10.3389/fvets.2021.639039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173081PMC
May 2021

Prognostic impact of the ratio of preoperative CA19-9 to liver enzyme levels in pancreatic cancer patients with jaundice (predictability of combined CA19-9/AST and CA19-9/γ-GGT for jaundiced PDAC patients).

Pancreatology 2021 May 26. Epub 2021 May 26.

Pancreas Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Pancreas Institute, Nanjing Medical University, Nanjing, China. Electronic address:

Background: Carbohydrate antigen 19-9 (CA19-9) has been reported as the most significant survival predictor of patients with pancreatic ductal adenocarcinoma (PDAC). However, the elevation of CA19-9 could interfere with obstructive jaundice and the predictive value of CA19-9 in PDAC patients with jaundice remains to be analyzed and elucidated to find possible adjustments.

Objective: To evaluate the predictability of preoperative CA19-9 and its adjustments for the overall survival (OS) of PDAC patients by analyzing the relationship between preoperative serum CA19-9 and total bilirubin (TBIL).

Methods: A total of 563 consecutive patients who underwent surgery for primary pancreatic adenocarcinoma in our center between January 2015 and September 2018 were retrospectively reviewed. Clinicopathologic information was collected and preoperative parameters such as CA19-9, CEA, TBIL, γ-GGT, AST, ALT, and ALP were recorded as well as overall survival rates, which began from the date of operation to that of death or the last follow-up. Kaplan-Meier survival curves with log-rank test and Cox regression models were applied using SPSS and the survival and survminer packages in R software.

Results: Using 39/390/1000 as the cut-off values for preoperative serum CA19-9, significant capability of OS stratification was found in the total cohort (p < 0.001, MST = 29.7/19.1/15.2/12.1 months) and patients with TBIL <102.6 μmol/L (p < 0.001, MST = 32.2/19.6/15.0/11.2 months). However, in the subgroup of TBIL≥102.6 μmol/L, this classification method was replaced by the combined scoring of CA19-9/AST and CA19-9/γ-GGT.

Conclusions: As an independent predictor of overall survival of PDAC patients, preoperative serum CA19-9 is defective in survival stratification when TBIL≥102.6 μmol/L but a positive survival prognosis could be achieved with the application of combined preoperative CA19-9/AST and CA19-9/γ-GGT.
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http://dx.doi.org/10.1016/j.pan.2021.05.300DOI Listing
May 2021

Numerical Simulation of Effect of Different Initial Morphologies on Melt Hydrodynamics in Laser Polishing of Ti6Al4V.

Micromachines (Basel) 2021 May 20;12(5). Epub 2021 May 20.

Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, South China Normal University, Guangzhou 510006, China.

As a surface finishing technique for rapid remelting and re-solidification, laser polishing can effectively eliminate the asperities so as to approach the feature size. Nevertheless, the polished surface quality is significantly sensitive to the processing parameters, especially with respect to melt hydrodynamics. In this paper, a transient two-dimensional model was developed to demonstrate the molten flow behavior for different surface morphologies of the Ti6Al4V alloy. It is illustrated that the complex evolution of the melt hydrodynamics involving heat conduction, thermal convection, thermal radiation, melting and solidification during laser polishing. Results show that the uniformity of the distribution of surface peaks and valleys can improve the molten flow stability and obtain better smoothing effect. The high cooling rate of the molten pool resulting in a shortening of the molten lifetime, which prevents the peaks from being removed by capillary and thermocapillary forces. It is revealed that the mechanism of secondary roughness formation on polished surface. Moreover, the double spiral nest Marangoni convection extrudes the molten to the outsides. It results in the formation of expansion and depression, corresponding to nearby the starting position and at the edges of the polished surface. It is further found that the difference between the simulation and experimental depression depths is only about 2 μm. Correspondingly, the errors are approximately 8.3%, 14.3% and 13.3%, corresponding to Models 1, 2 and 3, respectively. The aforementioned results illustrated that the predicted surface profiles agree reasonably well with the experimentally measured surface height data.
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http://dx.doi.org/10.3390/mi12050581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160783PMC
May 2021

Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis.

Pharmaceuticals (Basel) 2021 May 11;14(5). Epub 2021 May 11.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Cholestasis is an important predisposing factor of liver diseases, such as hepatocyte necrosis, liver fibrosis and primary biliary cirrhosis. In this study, we aimed to investigate the effects of Kinsenoside (KD), a natural active ingredient of , on estrogen-induced cholestatic liver injury in Sprague-Dawley rats and the underlying mechanism. The rats were randomly divided into six groups: control group, model group, low-dose KD group (50 mg/kg body weight, KD-L), medium-dose KD group (100 mg/kg body weight, KD-M), high-dose KD group (200 mg/kg body weight, KD-H) and ursodeoxycholic acid group (40 mg/kg body weight, UDCA). 17α-Ethinylestradiol (EE) was used to establish an experimental animal model of estrogen-induced cholestasis (EIC). The results demonstrated that KD alleviated liver pathologic damage, serum biochemical status and inhibited hepatocellular microstructure disorder and bile duct hyperplasia in EE-induced cholestatic rats. Mechanically, KD alleviated EE-induced cholestatic liver injury by inhibiting inflammatory responses and regulating bile acid homeostasis. Concretely, KD reduced the expression of IL-1β and IL-6 by inhibiting NF-κB p65 to suppress EE-mediated inflammation in rat liver. KD enhanced the expression of FXR and inhibited EE-mediated reduction of FXR in vitro and in vivo. It was the potential mechanism that KD mitigates cholestasis by increasing efflux and inhibiting uptake of bile acids via FXR-mediated induction of bile salt export pump (BSEP) and reduction of Na-dependent taurocholate cotransport peptide (NTCP) to maintain bile acid homeostasis. Moreover, KD repressed the bile acid synthesis through reducing the expression of synthetic enzyme (CYP7A1), thereby normalizing the expression of metabolic enzyme (SULT2A1) of bile acid. In conclusion, our results revealed that KD may be an effective drug candidate for the treatment of cholestasis.
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http://dx.doi.org/10.3390/ph14050452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151897PMC
May 2021

Co-infection analysis of bacterial and viral respiratory pathogens from clinically healthy swine in Eastern China.

Vet Med Sci 2021 May 25. Epub 2021 May 25.

Institute of Veterinary Medicine, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Porcine respiratory disease complex (PRDC) is one of the most challenging health concerns for pig production worldwide. The aim of the present study was to determine the prevalence of pathogens associated with PRDC, including porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) and bacterial agents, such as Streptococcus suis, Haemophilus parasuis and Actinobacillus pleuropneumoniae, in clinically healthy pigs in Eastern China. Molecular detection revealed positive single-pathogen detection rates of 59.9%, 27.2%, 52.3%, 33.2% and 0.4% for PCV2, PRRSV, S. suis, H. parasuis and A. pleuropneumoniae, respectively. Co-infection with more than one pathogen was frequently detected in these samples, with PCV2/S. suis, H. parasuis and PCV2/H. parasuis mixed infection rates of 35.4%, 33.2% and 21.6%, respectively, and PCV2/S. suis/H. parasuis and PRRSV/PCV2/S. suis co-infection rates of 21.6% and 6.2%, respectively. These results suggest that mixed infections are prevalent among PRDC cases in swine, which may pose a greater threat to the health of herds compared with single-pathogen infections.
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http://dx.doi.org/10.1002/vms3.533DOI Listing
May 2021

Coronary microvascular dysfunction pathophysiology in COVID-19.

Microcirculation 2021 May 20:e12718. Epub 2021 May 20.

Department of Cardiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Recently, accumulating evidence has highlighted the role of endothelial dysfunction in COVID-19 progression. Coronary microvascular dysfunction (CMD) plays a pivotal role in cardiovascular disease (CVD) and CVD-related risk factors (eg, age, gender, hypertension, diabetes mellitus, and obesity). Equally, these are also risk factors for COVID-19. The purpose of this review was to explore CMD pathophysiology in COVID-19, based on recent evidence. COVID-19 mechanisms were reviewed in terms of imbalanced renin-angiotensin-aldosterone-systems (RAAS), systemic inflammation and immune responses, endothelial dysfunction, and coagulatory disorders. Based on these mechanisms, we addressed CMD pathophysiology within the context of COVID-19, from five perspectives. The first was the disarrangement of local RAAS and Kallikrein-kinin-systems attributable to SARS-Cov-2 entry, and the concomitant decrease in coronary microvascular endothelial angiotensin I converting enzyme 2 (ACE2) levels. The second was related to coronary microvascular obstruction, induced by COVID-19-associated systemic hyper-inflammation and pro-thrombotic state. The third was focused on how pneumonia/acute respiratory distress syndrome (ARDS)-related systemic hypoxia elicited oxidative stress in coronary microvessels and cardiac sympathetic nerve activation. Fourthly, we discussed how autonomic nerve dysfunction mediated by COVID-19-associated mental, physical, or physiological factors could elicit changes in coronary blood flow, resulting in CMD in COVID-19 patients. Finally, we analyzed reciprocity between the coronary microvascular endothelium and perivascular cellular structures due to viremia, SARS-CoV-2 dissemination, and systemic inflammation. These mechanisms may function either consecutively or intermittently, finally culminating in CMD-mediated cardiovascular symptoms in COVID-19 patients. However, the underlying molecular pathogenesis remains to be clarified.
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http://dx.doi.org/10.1111/micc.12718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236988PMC
May 2021

Overexpressing microRNA-203 alleviates myocardial infarction via interacting with long non-coding RNA MIAT and mitochondrial coupling factor 6.

Arch Pharm Res 2021 May 4;44(5):525-535. Epub 2021 May 4.

Department of Cardiology, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, 16766 Jingshi Rd., Jinan, 250014, Shandong Province, China.

Myocardial infarction (MI) is one of the leading causes of high mortality worldwide. Long non-coding RNA myocardial infarction associated transcript (MIAT) and mitochondrial coupling factor 6 (CF6) aggravate MI. This study aimed to elucidate whether miR-203 interacted with MIAT and CF6 in MI. Results revealed that MIAT and CF6 expressions were upregulated and that miR-203 was downregulated in mouse myocardial tissues after MI, as well as in hypoxic mouse cardiomyocytes. The overexpression of MIAT in mouse cardiomyocytes raised CF6 expression, whereas the knockdown of MIAT had the opposite effect. Mechanistically, the luciferase reporter and RNA pull-down assays corroborated the binding between miR-203 and CF6 3'UTR and between miR-203 and MIAT. The simultaneous overexpression of miR-203 and MIAT restored the reduction of CF6 caused by miR-203 overexpression alone, and the overexpression of miR-203 diminished the percentage of infarct area and the apoptosis of cardiomyocytes in vivo. Our findings corroborate that overexpressing miR-203 alleviates MI via interacting with MIAT and CF6.
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http://dx.doi.org/10.1007/s12272-021-01324-8DOI Listing
May 2021

Gut Microbiota and Diarrhea: An Updated Review.

Front Cell Infect Microbiol 2021 15;11:625210. Epub 2021 Apr 15.

Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.
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http://dx.doi.org/10.3389/fcimb.2021.625210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082445PMC
July 2021

Dual effects of targeting S100A11 on suppressing cellular metastatic properties and sensitizing drug response in gastric cancer.

Cancer Cell Int 2021 Apr 30;21(1):243. Epub 2021 Apr 30.

Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

Background: S100A11 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. The dysregulated expression of the S100A11 gene has been implicated in tumour metastasis. However, the role of S100A11 protein in tumour cell response to chemotherapeutic drugs has not been characterised.

Methods: Transcript levels of S100A11 in gastric cancer were evaluated using an in-house patient cohort. Protein expression of S100A11 in gastric cancer was estimated by immunohistochemistry of a tissue microarray. The stable gastric cancer cell lines were established using lentiviral shRNA vectors. The knockdown of S100A11 was validated by qRT-PCR, PCR, and Western blot. The cellular function of S100A11 was estimated by assays of cell adhesion, migration, and invasion. The cell cytotoxic assay was performed to investigate the response to chemotherapeutic drugs. An unsupervised hierarchical clustering and principal component analysis (HCPC) was applied to unveil the dimensional role of S100A11 among all S100 family members in gastric cancer.

Results: High expression of S100A11 is associated with poor survival of gastric cancer patients (p < 0.001, HR = 1.85) and is an independent prognostic factor of gastric cancer. We demonstrate that S100A11 plays its role as a tumour promoter through regulating the MMP activity and the epithelial-mesenchymal transition (EMT) process. The stable knockdown of S100A11 suppresses the metastatic properties of gastric cancer cells, which include enhancing cell adhesion, but decelerating cell migration and invasion. Furthermore, the knockdown of S100A11 gene expression dramatically induces the cellular response of gastric cancer cells to the first-line chemotherapeutic drugs fluoropyrimidine 5-fluorouracil (5-FU) and cisplatin.

Conclusion: The present study identifies S100A11 as a tumour promoter in gastric cancer. More importantly, the S100A11-specific targeting potentially presents dual therapeutic benefits by not only controlling tumour progression but also sensitising chemotherapeutic cytotoxic response.
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http://dx.doi.org/10.1186/s12935-021-01949-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086328PMC
April 2021

Measuring Nature Contact: A Narrative Review.

Int J Environ Res Public Health 2021 04 13;18(8). Epub 2021 Apr 13.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.

While many studies suggest evidence for the health benefits of nature, there is currently no standardized method to measure time spent in nature or nature contact, nor agreement on how best to define nature contact in research. The purpose of this review is to summarize how nature contact has been measured in recent health research and provide insight into current metrics of exposure to nature at individual and population scales. The most common methods include surrounding greenness, questionnaires, and global positioning systems (GPS) tracking. Several national-level surveys exist, though these are limited by their cross-sectional design, often measuring only a single component of time spent in nature, and poor links to measures of health. In future research, exposure assessment combining the quantifying (e.g., time spent in nature and frequency of visits to nature) and qualifying (e.g., greenness by the normalized difference of vegetation index (NDVI) and ratings on perception by individuals) aspects of current methods and leveraging innovative methods (e.g., experience sampling methods, ecological momentary assessment) will provide a more comprehensive understanding of the health effects of nature exposure and inform health policy and urban planning.
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http://dx.doi.org/10.3390/ijerph18084092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069863PMC
April 2021

D-Galactose Induces Chronic Oxidative Stress and Alters Gut Microbiota in Weaned Piglets.

Front Physiol 2021 8;12:634283. Epub 2021 Apr 8.

Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.

Oxidative stress commonly occurs in pig production, which can severely damage the intestinal function of weaned piglets. This study was conducted to investigate the effects of D-galactose with different levels used to induce chronic oxidative stress on growth performance, intestinal morphology and gut microbiota in weaned piglets. The results showed that addition of 10 and 20 g/kg BW D-galactose reduced average daily gain and average daily feed intake from the first to the third week. 10 g/kg BW D-galactose increased the concentration of serum MDA at the second and third week. 10 g/kg BW D-galactose significantly influenced the jejunal and ileal expressions of , , and . The results of 16S rRNA sequencing showed that compared with the control, 10 and 20 g/kg BW D-galactose significantly decreased the relative abundance of , , , and , while increased the relative abundance of , , and . The results indicated that treatment with 10 g/kg BW/day D-galactose for 3 weeks could induce chronic oxidative stress, reduce the growth performance and alter gut microbiota in weaned piglets.
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http://dx.doi.org/10.3389/fphys.2021.634283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060641PMC
April 2021

Surface self-reconstructed amorphous/crystalline hybrid iron disulfide for high-efficiency water oxidation electrocatalysis.

Dalton Trans 2021 May 22;50(18):6333-6342. Epub 2021 Apr 22.

School of Materials Science and Engineering; School of Chemistry and Chemical Engineering; Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage; Liaocheng University, China.

Hybrid electrocatalysts derived from surface self-reconstruction during reaction processes can facilitate charge transfer between different phases and nanostructures by their unique interfaces. Herein, amorphous/crystalline hybrid iron disulfide obtained by self-reconstruction is developed for the first time for the oxygen evolution reaction (OER). The amorphous/crystalline hybrid FeS catalyst exhibited a high OER activity with an overpotential of only 189.5 mV (IR-corrected) to deliver 10 mA cm in 1.0 M KOH, which was superior to that of the commercial RuO. Notably, in the two-electrode system with the amorphous/crystalline hybrid FeS as the anode electrocatalyst and Pt/C as the cathode, the catalytic activity towards the overall water splitting was enhanced with a voltage of only 1.43 V at 10 mA cm. The phase, composition and surface structure were changed greatly before and after the reaction. All these surface reconstructions after the OER reaction may play significant roles in the high electronic catalytic efficiency. Therefore, the study of the surface reconstruction of catalysts during the reaction process is very important for the structure-performance relationship and the design of efficient hybrid electrocatalysts.
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http://dx.doi.org/10.1039/d1dt00730kDOI Listing
May 2021

Factors associated with overall survival in early gastric cancer patients who underwent additional surgery after endoscopic submucosal dissection.

World J Clin Cases 2021 Apr;9(10):2192-2204

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing 100050, China.

Background: Controversy exists about the benefit of additional surgery after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC).

Aim: To examine risk factors for overall survival (OS) after additional surgery in patients with EGC who initially underwent ESD.

Methods: This was a retrospective analysis of patients with EGC who underwent additional surgery after ESD at the Beijing Friendship Hospital affiliated to Capital Medical University between August 2012 and August 2019. OS was the primary outcome. Lymph node metastasis and residual tumor were secondary outcomes. Logistic regression models and Kaplan-Meier curves were used for further analysis.

Results: Forty-two patients were evaluated, including 35 (83.3%) males and 7(16.7%) females. The mean age was 62 (range, 32-82) years. Male sex [hazard ratio (HR) = 21.906, 95% confidence interval (CI): 3.762-229.250; = 0.039), T1b invasion (HR = 3.965, 95%CI: 1.109-17.432; = 0.047), undifferentiated tumor (HR = 9.455, 95%CI: 0.946-29.482; = 0.049), lymph node metastasis (HR = 2.126, 95%CI: 0.002-13.266; = 0.031), and residual tumor (HR = 4.275, 95%CI: 1.049-27.420; = 0.043) were independently associated with OS. The follow-up duration was 4-81 mo (median: 50.7 mo). OS was 77.0 ± 12.1 mo (95%CI: 53.3-100.7 mo). The 3-year and 5-year OS rates were 94.1% and 85%, respectively.

Conclusion: Male sex, T1b invasion, undifferentiated tumor, lymph node metastasis, and residual tumor are independently associated with OS in patients with EGC who underwent additional surgery after ESD.
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http://dx.doi.org/10.12998/wjcc.v9.i10.2192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026836PMC
April 2021
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