Publications by authors named "Jie Su"

399 Publications

Buddleoside-Rich L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway.

Front Pharmacol 2021 8;12:755140. Epub 2021 Oct 8.

School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.

As the number of patients with metabolic hypertension (MH) is increasing, there is an essential require for global measures to prevent and treat MH. Flavonoids such as buddleoside (BUD) from L. are the main pharmacological components of cardiovascular activities. Previous studies have suggested that the buddleoside-rich L. extract (BUDE) can reduce blood pressure in spontaneously hypertensive rats (SHR). However, its effect on MH and how it works remains to be researched. In this study, it was observed that BUDE could lower blood pressure, improve dyslipidemia, and decrease the level of plasma LPS in MH rats. Moreover, BUDE improved intestinal flora and increased the expression of occludin and claudin-1 in the colon, and improved the pathological injury of the colon. Western bolt and qRT-PCR experiments showed that BUDE could down-regulate TLR4 and MyD88 protein and mRNA expression and inhibit phosphorylation of IKKβ, IκBα and NF-κB p65 in vessels of MH rats. These results showed that BUDE could regulate intestinal flora, improve intestinal barrier function, reduce the production and penetration of LPS, thereby inhibiting the vascular TLR4/MyD88 pathway, improving vascular endothelial function, and ultimately lowering blood pressure in MH rats. This study provides a new mechanism of BUDE against MH by inhibiting the enteric-origin LPS/TLR4 pathway.
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http://dx.doi.org/10.3389/fphar.2021.755140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532163PMC
October 2021

Peridynamic Simulation to Fracture Mechanism of CBN Grain in the Honing Wheel Dressing Process.

Micromachines (Basel) 2021 Sep 29;12(10). Epub 2021 Sep 29.

Department of Mechanical Engineering, University of Kansas, Lawrence, KS 66045, USA.

Regularly dressing of CBN honing wheel is an effective way to keep its sharpness and correct geometry during honing process. This study aims to understand the fracture mechanism of single CBN grain in the dressing process of honing wheel. The honing wheel dressing process was simplified into the dressing process of grinding wheel, and the bond-based Peridynamic method considering bond rotation effect was developed to investigate the progressive fracture evolution, stress characteristics, and fracture modes of CBN grains in this process. It was found that fracture evolution of CBN grains mainly underwent four stages: elastic deformation, damage initiation, crack formation, and macro fracture. In addition, the fracture initiation and propagation were mainly determined by the tensile and shear stress, where the former led to mode I fractures and the latter led to mode II fractures. The propagation of mode I fractures was stable while the propagation of mode II fracture was unstable. The results show that the Peridynamic approach has great potential to predict the fracture mechanism of CBN grain in the dressing process of honing and grinding wheels.
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http://dx.doi.org/10.3390/mi12101186DOI Listing
September 2021

Manifold dynamic non-covalent interactions for steering molecular assembly and cyclization.

Chem Sci 2021 Sep 5;12(35):11659-11667. Epub 2021 Aug 5.

Department of Chemistry, National University of Singapore 3 Science Drive 3 Singapore 117543

Deciphering rich non-covalent interactions that govern many chemical and biological processes is crucial for the design of drugs and controlling molecular assemblies and their chemical transformations. However, real-space characterization of these weak interactions in complex molecular architectures at the single bond level has been a longstanding challenge. Here, we employed bond-resolved scanning probe microscopy combined with an exhaustive structural search algorithm and quantum chemistry calculations to elucidate multiple non-covalent interactions that control the cohesive molecular clustering of well-designed precursor molecules and their chemical reactions. The presence of two flexible bromo-triphenyl moieties in the precursor leads to the assembly of distinct non-planar dimer and trimer clusters by manifold non-covalent interactions, including hydrogen bonding, halogen bonding, C-H⋯π and lone pair⋯π interactions. The dynamic nature of weak interactions allows for transforming dimers into energetically more favourable trimers as molecular density increases. The formation of trimers also facilitates thermally-triggered intermolecular Ullmann coupling reactions, while the disassembly of dimers favours intramolecular cyclization, as evidenced by bond-resolved imaging of metalorganic intermediates and final products. The richness of manifold non-covalent interactions offers unprecedented opportunities for controlling the assembly of complex molecular architectures and steering on-surface synthesis of quantum nanostructures.
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http://dx.doi.org/10.1039/d1sc03733aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442717PMC
September 2021

Privacy protection of medical data in social network.

BMC Med Inform Decis Mak 2021 Oct 18;21(Suppl 1):286. Epub 2021 Oct 18.

Department of Hematopathology and Lab Medicines, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.

Background: Protection of privacy data published in the health care field is an important research field. The Health Insurance Portability and Accountability Act (HIPAA) in the USA is the current legislation for privacy protection. However, the Institute of Medicine Committee on Health Research and the Privacy of Health Information recently concluded that HIPAA cannot adequately safeguard the privacy, while at the same time researchers cannot use the medical data for effective researches. Therefore, more effective privacy protection methods are urgently needed to ensure the security of released medical data.

Methods: Privacy protection methods based on clustering are the methods and algorithms to ensure that the published data remains useful and protected. In this paper, we first analyzed the importance of the key attributes of medical data in the social network. According to the attribute function and the main objective of privacy protection, the attribute information was divided into three categories. We then proposed an algorithm based on greedy clustering to group the data points according to the attributes and the connective information of the nodes in the published social network. Finally, we analyzed the loss of information during the procedure of clustering, and evaluated the proposed approach with respect to classification accuracy and information loss rates on a medical dataset.

Results: The associated social network of a medical dataset was analyzed for privacy preservation. We evaluated the values of generalization loss and structure loss for different values of k and a, i.e. [Formula: see text] = {3, 6, 9, 12, 15, 18, 21, 24, 27, 30}, a = {0, 0.2, 0.4, 0.6, 0.8, 1}. The experimental results in our proposed approach showed that the generalization loss approached optimal when a = 1 and k = 21, and structure loss approached optimal when a = 0.4 and k = 3.

Conclusion: We showed the importance of the attributes and the structure of the released health data in privacy preservation. Our method achieved better results of privacy preservation in social network by optimizing generalization loss and structure loss. The proposed method to evaluate loss obtained a balance between the data availability and the risk of privacy leakage.
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http://dx.doi.org/10.1186/s12911-021-01645-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524799PMC
October 2021

Analysis of risk factors and countermeasures of sepsis-associated encephalopathy.

Minerva Surg 2021 Oct 15. Epub 2021 Oct 15.

Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China -

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http://dx.doi.org/10.23736/S2724-5691.21.09176-0DOI Listing
October 2021

Visualizing designer quantum states in stable macrocycle quantum corrals.

Nat Commun 2021 Oct 8;12(1):5895. Epub 2021 Oct 8.

Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore.

Creating atomically precise quantum architectures with high digital fidelity and desired quantum states is an important goal in a new era of quantum technology. The strategy of creating these quantum nanostructures mainly relies on atom-by-atom, molecule-by-molecule manipulation or molecular assembly through non-covalent interactions, which thus lack sufficient chemical robustness required for on-chip quantum device operation at elevated temperature. Here, we report a bottom-up synthesis of covalently linked organic quantum corrals (OQCs) with atomic precision to induce the formation of topology-controlled quantum resonance states, arising from a collective interference of scattered electron waves inside the quantum nanocavities. Individual OQCs host a series of atomic orbital-like resonance states whose orbital hybridization into artificial homo-diatomic and hetero-diatomic molecular-like resonance states can be constructed in Cassini oval-shaped OQCs with desired topologies corroborated by joint ab initio and analytic calculations. Our studies open up a new avenue to fabricate covalently linked large-sized OQCs with atomic precision to engineer desired quantum states with high chemical robustness and digital fidelity for future practical applications.
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http://dx.doi.org/10.1038/s41467-021-26198-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501084PMC
October 2021

Electron angular correlation in nonsequential double ionization of molecules by counter-rotating two-color circularly polarized fields.

Opt Express 2021 Aug;29(18):29576-29586

Electron correlation in nonsequential double ionization (NSDI) of molecules by counter-rotating two-color circularly polarized (TCCP) fields is investigated with a three-dimensional classical ensemble model. Numerical results indicate that the two electrons from NSDI of molecules in counter-rotating TCCP fields show strong angular correlation and the angular correlation behavior sensitively depends on the internuclear distance. With the internuclear distance increasing, the dominant behavior of electron pairs evolves from correlation to anti-correlation. It leaves a clear imprint on the ion momentum distributions, which exhibit an inverted Y-shape distribution at a small internuclear distance and a triangle-shape distribution at a large internuclear distance. Back analysis indicates that the asymmetric electron energy sharing by soft recollision and longer time delay of double ionization are responsible for more anti-correlated emissions at large internuclear distances.
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http://dx.doi.org/10.1364/OE.439864DOI Listing
August 2021

Cutting Performance of Randomly Distributed Active Abrasive Grains in Gear Honing Process.

Micromachines (Basel) 2021 Sep 17;12(9). Epub 2021 Sep 17.

Department of Mechanical Engineering, University of Kansas, Lawrence, KS 66045, USA.

In power gear honing, the random distribution of abrasive grains on the tooth surface of the honing wheel is the main factor that influences the machining performance of high-quality hardened gears. In order to investigate the micro-edge cutting performance of the active abrasive grains on the workpiece gear, the real honing process is simplified into a micro-edge cutting model with random distribution of active abrasive grains in the cells of the meshing area by obtaining the random distribution states such as the position, orientation and quantity of the honing wheel teeth. The results show that although the active abrasive grains are distributed at different locations, they all experience three types of material removal-slip rubbing, plowing and cutting-allowing the gear honing process to have the combined machining characteristics of grinding, lapping and polishing. The active abrasive grains in first contact produce high honing force, high material removal efficiency and poor surface roughness on the machined workpiece, while the latter ones have the opposite effects. The dislocation angle affects the chip shape and chip discharging direction, and the highest honing force and material removal efficiency is achieved with a dislocation angle of 135°. The higher the number of active abrasive grains in a given contact area, the higher the material removal efficiency.
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http://dx.doi.org/10.3390/mi12091119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467435PMC
September 2021

Microstructures and electronic characters of β-GaO on different substrates: exploring the role of surface chemistry and structures.

Phys Chem Chem Phys 2021 Oct 6;23(38):21874-21882. Epub 2021 Oct 6.

State Key Lab of Solidification Processing, College of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, P. R. China.

Unveiling the microstructural and electronic properties of β-GaO on different substrates is vital to realize the high quality and performance of β-GaO. Here, the microstructure disorder, defect characters and orbital structures of β-GaO on the AlO, MgO, and SiC substrates with different terminations are studied. Although several growth mechanisms for β-GaO are observed on the same substrate, β-GaO prefers to deposit the octahedral Ga atom firstly on the AlO and MgO substrates, and the latter can restrain the oxygen-vacancy formation and migration. The structural disorder, band offsets and gap states can be improved upon depositing β-GaO on a substrate with metal terminations under the oxygen-poor conditions. Compared to the AlO substrate, β-GaO on the SiC substrate shows a smaller structure disorder and a higher defect formation energy, in particular under the oxygen-rich conditions, since β-GaO prefers to deposit the tetrahedral Ga atom firstly on the SiC substrate to form a SiC-GaO interface with less dangling bonds. The type-II band alignment of the SiC-GaO interface can be changed into the type-I character with larger band offsets when β-GaO is deposited under the oxygen-rich conditions, irrespective of the termination of the SiC substrate. These results provide a useful understanding of the effect of substrates on the quality and performance of β-GaO and a scientific basis for the application of substrate-GaO interfaces.
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http://dx.doi.org/10.1039/d1cp02687aDOI Listing
October 2021

Tailoring long-range superlattice chirality in molecular self-assemblies weak fluorine-mediated interactions.

Phys Chem Chem Phys 2021 Oct 6;23(38):21489-21495. Epub 2021 Oct 6.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

Controllable fabrication of enantiospecific molecular superlattices is a matter of imminent scientific and technological interest. Herein, we demonstrate that long-range superlattice chirality in molecular self-assemblies can be tailored by tuning the interplay of weak intermolecular non-covalent interactions between hexaphenylbenzene-based enantiomers. By means of high-resolution scanning tunneling microscopy measurements, we demonstrate that the functionalization of a hexaphenylbenzene-based molecule with fluorine (F) atoms leads to the formation of molecular self-assemblies with distinct long-range chiral recognition patterns. We employed density functional theory calculations to quantify F-mediated lone pair F⋯π, C-H⋯F, and F⋯F interactions attributed to the distinct enantiospecific molecular self-organizations. Our findings underpin a viable route to fabricate long-range chiral recognition patterns in supramolecular assemblies by engineering the weak non-covalent intermolecular interactions.
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http://dx.doi.org/10.1039/d1cp02996gDOI Listing
October 2021

Cognitive Impairment and Delirium in Older Patients Undergoing Major Head and Neck Surgery.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211045293. Epub 2021 Sep 21.

Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.

The study objective was to measure the prevalence and predictors of cognitive impairment (CI) and delirium. Adults undergoing major head and neck cancer surgery completed the Clock Draw Test to screen for CI, defined as a score of 0 or 1. Postoperative delirium was recorded. Predictors of delirium and length of stay were assessed by univariate logistic regression and the latter with multivariate linear regression. Overall 274 patients were included, of which 47% had a Clock Draw Test score of 0 or 1. Post-operative delirium occurred in 17 (6%). CI was a predictor of postoperative delirium (odds ratio, 3.9; 95% CI, 1.2-12; = .02). Postoperative delirium was a predictor of increased length of stay (adjusted odds ratio, 1.30; 95% CI, 1.07-1.57; = .0073) on multivariate regression while baseline Clock Draw Test result was not a predictor on univariate regression ( = .98). Screening for CI can help predict delirium and facilitate targeted interventions in the postoperative period.
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http://dx.doi.org/10.1177/01945998211045293DOI Listing
September 2021

A meta-analysis of the ecological and economic outcomes of mangrove restoration.

Nat Commun 2021 08 19;12(1):5050. Epub 2021 Aug 19.

Institute for Future Initiatives (IFI), The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Mangrove restoration has become a popular strategy to ensure the critical functions and economic benefits of this ecosystem. This study conducts a meta-analysis of the peer-reviewed literature on the outcomes of mangrove restoration. On aggregate, restored mangroves provide higher ecosystem functions than unvegetated tidal flats but lower than natural mangrove stands (respectively RR' = 0.43, 95%CIs = 0.23 to 0.63; RR' = -0.21, 95%CIs = -0.34 to -0.08), while they perform on par with naturally-regenerated mangroves and degraded mangroves. However, restoration outcomes vary widely between functions and comparative bases, and are mediated by factors such as restoration age, species, and restoration method. Furthermore, mangrove restoration offers positive benefit-cost ratios ranging from 10.50 to 6.83 under variable discount rates (-2% to 8%), suggesting that mangrove restoration is a cost-effective form of ecosystem management. Overall, the results suggest that mangrove restoration has substantial potential to contribute to multiple policy objectives related to biodiversity conservation, climate change mitigation and sustainable development.
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http://dx.doi.org/10.1038/s41467-021-25349-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376958PMC
August 2021

Evaluation of Sarcopenia in Older Patients Undergoing Head and Neck Cancer Surgery.

Laryngoscope 2021 Aug 12. Epub 2021 Aug 12.

Department of Otolaryngology Head and Neck Surgery/Surgical Oncology, University Health Network, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.

Objectives/hypothesis: Sarcopenia is a hallmark of aging and its identification may help predict adverse postoperative events in patients undergoing head and neck surgery. The study objective was to assess the relationship between sarcopenia and postoperative complications and length of stay in patients undergoing major head and neck cancer surgery.

Study Design: Prospective cohort study.

Methods: A prospective cohort study was performed of patients 50 years and older undergoing major head and neck surgery. Sarcopenia was defined as low muscle mass (determined by neck muscle cross-sectional imaging) with either low muscle strength (grip strength) or low muscle performance (timed walk test). Logistic regression was applied on binary outcomes, and linear regression was used for log-transformed length of hospital stay (LOS). Univariate and multivariate analyses were performed.

Results: Of the 251 patients enrolled, pre-sarcopenia was present in 34.9% (n = 87) and sarcopenia in 15.6% (n = 39) of patients. Patients with sarcopenia were more likely to be older (P = .001), female (P = .001), have a lower body mass index (P = .001), and lower preoperative hemoglobin (P < .001). On univariate analysis, the presence and severity of sarcopenia was associated with the development of medical complications (P = .029), higher grade of complications (P = .032), LOS (P = .015), and overall survival (P = .001). On multivariate analysis, sarcopenia was associated with a longer LOS (β = 0.32 [95% CI: 0.19-0.45], P < .001) and worse overall survival (HR = 2.21 [95% CI: 1.01-4.23], P = .017).

Conclusions: Sarcopenia may aid in the prediction of prolonged hospital stay and death in patients who are candidates for major head and neck surgery.

Level Of Evidence: 3 Laryngoscope, 2021.
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http://dx.doi.org/10.1002/lary.29782DOI Listing
August 2021

Association of Pharyngocutaneous Fistula With Cancer Outcomes in Patients After Laryngectomy: A Multicenter Collaborative Cohort Study.

JAMA Otolaryngol Head Neck Surg 2021 Jul 29. Epub 2021 Jul 29.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Importance: Pharyngocutaneous fistula (PCF) results in an inflammatory reaction, but its association with the rate of locoregional and distant control, disease-free survival, and overall survival in laryngeal cancer remains uncertain.

Objective: To determine if pharyngocutaneous fistula after salvage laryngectomy is associated with locoregional and distant control, disease-free survival, and/or overall survival.

Design, Setting, And Participants: A multicenter collaborative retrospective cohort study conducted at 5 centers in Canada and the US of 550 patients who underwent salvage laryngectomy for recurrent laryngeal cancer from January 1, 2000, to December 31, 2014. The median follow-up time was 5.7 years (range, 0-18 years).

Main Outcomes And Measures: Outcomes examined included locoregional and distant control, disease-free survival, and overall survival. Fine and Gray competing risk regression and Cox-proportional hazard regression models were used for outcomes. Competing risks and the Kaplan-Meier methods were used to estimate outcomes at 3 years and 5 years.

Results: In all, 550 patients (mean [SD] age, 64 [10.4] years; men, 465 [85%]) met inclusion criteria. Pharyngocutaneous fistula occurred in 127 patients (23%). The difference in locoregional control between the group of patients with PCF (75%) and the non-PCF (72%) group was 3% (95% CI, -6% to 12%). The difference in overall survival between the group with PCF (44%) and the non-PCF group (52%) was 8% (95% CI, -2% to 20%). The difference in disease-free survival between PCF and non-PCF groups was 6% (95% CI, -4% to 16%). In the multivariable model, patients with PCF were at a 2-fold higher rate of distant metastases (hazard ratio, 2.00; 95% CI, 1.22 to 3.27). Distant control was reduced in those with PCF, a 13% (95% CI, 3% to 21%) difference in 5-year distant control.

Conclusions And Relevance: This multicenter retrospective cohort study found that development of PCF after salvage laryngectomy is associated with an increased risk for the development of distant metastases.
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http://dx.doi.org/10.1001/jamaoto.2021.1545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323048PMC
July 2021

Novel polysaccharide extracted from Sipunculus nudus inhibits HepG2 tumour growth in vivo by enhancing immune function and inducing tumour cell apoptosis.

J Cell Mol Med 2021 Sep 24;25(17):8338-8351. Epub 2021 Jul 24.

Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai Key Laboratory of Marine Bioresources and Environment, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China.

A novel polysaccharide was extracted from Sipunculus nudus (SNP). The molecular weight (MW) of SNP was determined to be 9223 Da by high-performance gel permeation chromatography analyses, and the structure of the SNP repeat units was determined to be →3,4-β-D-GlcpNAC (1→ and →4) -α-D-Glcp (1→ in the ratio of 15:1; →2) -α -D-Galp - (1→ as a side chain; and β-D-Galp-(1→ and α- D-Glcp - (1→ as end groups by GC-MS analysis and NMR assays. The effect of SNP on hepatoma HepG2-bearing mice was analysed to verify its potential in the clinical treatment of liver cancer. A total of 90 male athymic nu/nu mice were divided into therapeutic and preventive groups and fed with different amounts of SNP. The antitumour effect of SNP on HepG2-bearing mice and mechanism of such were studied by analysing the tumour size, spleen index, thymus index, immune factors in the blood, tumour apoptosis factors, etc. The results suggest that SNP not only increased the index of immune organs in the body, but also enhanced the secretion of immune factors, including interleukin-2, interferon gamma and tumour necrosis factor-alpha in the serum. SNP induced the apoptosis of tumour cells via the mitochondrial apoptosis pathway, which upregulated caspase-3, caspase-8, caspase-9 and BCL2-associated X, but downregulated B-cell lymphoma-2 and vascular endothelial growth factor protein expression. In conclusion, SNP inhibited tumour growth by enhancing immune function and inducing tumour cell apoptosis in HepG2-bearing mice. Therefore, SNP may be further investigated as a promising candidate for future antitumour drugs.
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http://dx.doi.org/10.1111/jcmm.16793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419178PMC
September 2021

Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.

PLoS Genet 2021 07 22;17(7):e1009671. Epub 2021 Jul 22.

Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Japan.

Gross chromosomal rearrangements (GCRs), including translocation, deletion, and inversion, can cause cell death and genetic diseases such as cancer in multicellular organisms. Rad51, a DNA strand exchange protein, suppresses GCRs by repairing spontaneous DNA damage through a conservative way of homologous recombination, gene conversion. On the other hand, Rad52 that catalyzes single-strand annealing (SSA) causes GCRs using homologous sequences. However, the detailed mechanism of Rad52-dependent GCRs remains unclear. Here, we provide genetic evidence that fission yeast Rad8/HLTF facilitates Rad52-dependent GCRs through the ubiquitination of lysine 107 (K107) of PCNA, a DNA sliding clamp. In rad51Δ cells, loss of Rad8 eliminated 75% of the isochromosomes resulting from centromere inverted repeat recombination, showing that Rad8 is essential for the formation of the majority of isochromosomes in rad51Δ cells. Rad8 HIRAN and RING finger mutations reduced GCRs, suggesting that Rad8 facilitates GCRs through 3' DNA-end binding and ubiquitin ligase activity. Mms2 and Ubc4 but not Ubc13 ubiquitin-conjugating enzymes were required for GCRs. Consistent with this, mutating PCNA K107 rather than the well-studied PCNA K164 reduced GCRs. Rad8-dependent PCNA K107 ubiquitination facilitates Rad52-dependent GCRs, as PCNA K107R, rad8, and rad52 mutations epistatically reduced GCRs. In contrast to GCRs, PCNA K107R did not significantly change gene conversion rates, suggesting a specific role of PCNA K107 ubiquitination in GCRs. PCNA K107R enhanced temperature-sensitive growth defects of DNA ligase I cdc17-K42 mutant, implying that PCNA K107 ubiquitination occurs when Okazaki fragment maturation fails. Remarkably, K107 is located at the interface between PCNA subunits, and an interface mutation D150E bypassed the requirement of PCNA K107 and Rad8 ubiquitin ligase for GCRs. These data suggest that Rad8-dependent PCNA K107 ubiquitination facilitates Rad52-dependent GCRs by changing the PCNA clamp structure.
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http://dx.doi.org/10.1371/journal.pgen.1009671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297803PMC
July 2021

Synergistic Interface Layer Optimization and Surface Passivation with Fluorocarbon Molecules toward Efficient and Stable Inverted Planar Perovskite Solar Cells.

Research (Wash D C) 2021 28;2021:9836752. Epub 2021 Jun 28.

State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, Shaanxi Joint Key Laboratory of Graphene, School of Microelectronics, Xidian University, 2 South Taibai Road, Xi'an 710071, China.

Large-size organic halide passivation has been considered an efficient approach to enhance the perovskite solar cell (PSC) efficiency and stability. Herein, a facile posttreatment strategy was demonstrated, wherein trifluoromethyl-phenethylamine hydrobromide (CF-PEABr) is firstly used to passivate the perovskite film surface. The CF-PEABr surface posttreatment could coordinate with halide dangling bonds that exist at the perovskite crystal surface. Moreover, the surface treatment with CF-PEABr could efficiently passivate the defects in the perovskite film and suppress the nonradiative carrier recombination. As a result, a high efficiency of 21.3% is obtained, and an increment of 80 mV in (a large of 1.15 V, with a 0.42 V voltage deficit) occurs, compared to the control device. To relieve the hydrophobic nature properties of the -CF functional group and the dewetting problem of PCBM layer deposition, a surfactant Triton X-100 is used to modify the PCBM layer. Furthermore, the devices with CF-PEABr posttreatment exhibit better operational, thermal (85°C), and long storage stabilities without any encapsulation.
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http://dx.doi.org/10.34133/2021/9836752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261667PMC
June 2021

An improved novel quantum image representation and its experimental test on IBM quantum experience.

Sci Rep 2021 Jul 6;11(1):13879. Epub 2021 Jul 6.

College of Information and Electrical Engineering, China Agricultural University, Beijing, 100083, China.

Quantum image representation (QIR) is a necessary part of quantum image processing (QIP) and plays an important role in quantum information processing. To address the problems that NCQI cannot handle images with inconsistent horizontal and vertical position sizes and multi-channel image processing, an improved color digital image quantum representation (INCQI) model based on NCQI is proposed in this paper. The INCQI model can process color images and facilitate multi-channel quantum image transformations and transparency information processing of images using auxiliary quantum bits. In addition, the quantum image control circuit was designed based on INCQI. And quantum image preparation experiments were conducted on IBM Quantum Experience (IBMQ) to verify the feasibility and effectiveness of INCQI quantum image preparation. The prepared image information was obtained by quantum measurement in the experiment, and the visualization of quantum information was successfully realized. The research in this paper has some reference value for the research related to QIP.
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http://dx.doi.org/10.1038/s41598-021-93471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260717PMC
July 2021

Enhanced Efficiency and Stability of All-Inorganic CsPbI Br Perovskite Solar Cells by Organic and Ionic Mixed Passivation.

Adv Sci (Weinh) 2021 Sep 30;8(17):e2101367. Epub 2021 Jun 30.

State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology, School of Microelectronics, Xidian University, 2 South Taibai Road, Xi'an, 710071, China.

All-inorganic perovskites have been intensively investigated as potential optoelectronic materials because of their excellent thermal stability, especially for CsPbI Br. Herein, the authors studied the effects of mixed passivation utilizing organic phenylethylammonium bromide and inorganic ionic cesium bromide (PEABr + CsBr) on the all-inorganic perovskite (CsPbI Br) solar cells for the first time. The treatment with different passivation mechanisms enhances the perovskite film quality, resulting in uniform surface morphology and compact film with low trap density. Besides, the passivation improves the energy level alignment, which benefits the hole extraction at the perovskite/HTL interface and drives the interface electron separation, suppressing the charge recombination and realizing a high open-circuit voltage (V ). Finally, the device represents a high power conversion efficiency (PCE) of 16.70%, a V of 1.30 V, and an excellent fill factor (FF) of 0.82. The V loss and high FF should be among the best values for CsPbI Br based devices. Furthermore, the treated devices exhibit remarkable long-term stability with only 8% PCE loss after storing in a glove box for more than 1000 h without encapsulation.
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http://dx.doi.org/10.1002/advs.202101367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425869PMC
September 2021

Outcome and treatment toxicity in east-indian versus white-canadian patients with oral cavity cancer following postoperative (chemo-)radiotherapy delivered under similar multidisciplinary care: A propensity-matched cohort study.

Oral Oncol 2021 Sep 25;120:105419. Epub 2021 Jun 25.

Department of Radiation Oncology, The Princess Margaret Cancer Centre/University of Toronto, Canada; Department of Otolaryngology-Head & Neck Surgery, The Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address:

Purpose: We compare clinical behaviour of East-Indians and White-Canadians with oral cavity squamous cell carcinoma (OSCC) treated at a Western institution within a uniform health care system.

Materials/methods: Newly diagnosed OSCC patients who underwent postoperative (chemo-)radiotherapy (PORT/POCRT) between 2005 and 2017 were included. Data on ethnicity and other variables were extracted from patient-questionnaires, a prospective database and supplemented by chart review. Baseline characteristics were compared between East-Indian versus White-Canadian groups. A propensity-matched (1:1 ratio) of East-Indian versus White-Canadian cohorts was generated to compare locoregional control (LRC), distant control (DC), overall survival (OS), and acute and late toxicities.

Results: A total of 53 East-Indian and 467 White-Canadian OSCC patients were identified. Compared to White-Canadians, East-Indian patients were younger, had less exposure to smoking and alcohol (p < 0.001), but more chewed betel (areca) nut /tobacco (43% vs 0.2%, p < 0.001). Buccal/retromolar-trigone/lower gingiva primaries were more common in East-Indians (49% vs 25%, p < 0.001). Median follow-up was 5.0 years. Propensity-score paired analysis revealed inferior 3-year LRC (68% vs 81%, p = 0.030), non-significantly lower OS (61% vs 75%, p = 0.257), but similar DC (81% vs 87%, p = 0.428) in East-Indian versus White-Canadian patients. Actuarial rate of toxicities was higher in East-Indians vs White-Canadians: acute toxicity at 6 weeks: 47% vs 30%, p = 0.012; chronic trismus at 5-years: 16% vs 2%, p = 0.013.

Conclusion: East-Indian OSCC patients have a greater betel nut/ chewable tobacco exposure compared to White-Canadians and a different distribution of OSCC sites. Propensity-matched cohort analysis showed lower LRC and higher toxicities in East-Indian OSCC patients, suggesting a complicated interaction between genetic/biological and life-style factors.
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http://dx.doi.org/10.1016/j.oraloncology.2021.105419DOI Listing
September 2021

Analysis of 85 Cases of Minimal Media Lower Hemisternotomy for Congenital Cardiac Surgery Under Cardiopulmonary Bypass in Infants.

Heart Surg Forum 2021 06 10;24(3):E502-E505. Epub 2021 Jun 10.

Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China

Objective: To investigate the feasibility and effect of minimal media lower hemisternotomy for cardiac surgery under cardiopulmonary bypass (CPB) in infant congenital heart disease.

Methods: In our hospital from May 2019 to October 2019, 170 infants with congenital heart disease underwent surgical treatment (median age 6.6 months; weight 6.0 kg). They were divided into 2 groups: those with conventional chest median incision and those with minimal sternotomy. Minimal lower hemisternotomy began from the third intercostal level and ended 0.5 cm above the xiphoid, just enough to insert a small sternal distractor.

Results: There was no significant difference between the 2 groups in CPB time. The operation time of small incision group was slightly longer (P < .05). There was no difference in prognosis between the 2 groups, but the wound length of the small incision group was significantly reduced (4.0 ± 0.5 versus 7.8 ± 0.8 cm, P < .05). Time of intensive care unit and hospital stay was shorter among hemisternotomy patients at a statistically significant level (P < .05).

Conclusion: Minimal media lower hemisternotomy with the basic advantages of the sternal incision can expose the various parts of the heart, which meets most cardiac exploration and surgical operation needs, and the incision may still be extended if necessary. Lower hemisternotomy appears to be a safe, effective, and versatile alternative for many surgical interventions in infants with congenital heart disease.
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http://dx.doi.org/10.1532/hsf.3577DOI Listing
June 2021

Lead halide-templated crystallization of methylamine-free perovskite for efficient photovoltaic modules.

Science 2021 06;372(6548):1327-1332

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China.

Upscaling efficient and stable perovskite layers is one of the most challenging issues in the commercialization of perovskite solar cells. Here, a lead halide-templated crystallization strategy is developed for printing formamidinium (FA)-cesium (Cs) lead triiodide perovskite films. High-quality large-area films are achieved through controlled nucleation and growth of a lead halide•-methyl-2-pyrrolidone adduct that can react in situ with embedded FAI/CsI to directly form α-phase perovskite, sidestepping the phase transformation from δ-phase. A nonencapsulated device with 23% efficiency and excellent long-term thermal stability (at 85°C) in ambient air (~80% efficiency retention after 500 hours) is achieved with further addition of potassium hexafluorophosphate. The slot die-printed minimodules achieve champion efficiencies of 20.42% (certified efficiency 19.3%) and 19.54% with an active area of 17.1 and 65.0 square centimeters, respectively.
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http://dx.doi.org/10.1126/science.abh1035DOI Listing
June 2021

Opportunities and challenges to the use of neutralizing monoclonal antibody therapies for COVID-19.

Authors:
Jie Su Hongzhou Lu

Biosci Trends 2021 Sep 16;15(4):205-210. Epub 2021 Jun 16.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

The coronavirus disease 2019 (COVID-19) pandemic has resulted in a substantial global public healthcare crisis, leading to the urgent need for effective therapeutic strategies. Neutralizing antibodies (nAbs) are a potential treatment for COVID-19. This article provides a brief overview of the targets and development of nAbs against COVID-19, and it examines the efficacy of nAbs as part of both outpatient and inpatient treatments based on emerging clinical trial data. Assessment of several promising candidates in clinical trials highlights the potential of nAbs to be an effective therapeutic to treat COVID-19 in outpatient settings. Nevertheless, the efficacy of nAbs treatment for hospitalized patients varies. In addition, this review identifies challenges to ending the COVID-19 pandemic, including concerns over nAbs development and clinical use. Resistant variants significantly threaten the availability of nAb-based therapeutics. This review also discusses other approaches that may improve the clinical benefit of neutralizing mAbs.
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http://dx.doi.org/10.5582/bst.2021.01227DOI Listing
September 2021

The effects of cryopreservation on the acrosome structure, enzyme activity, motility, and fertility of bovine, ovine, and goat sperm.

Anim Reprod 2021 Mar 8;17(4):e20200219. Epub 2021 Mar 8.

College of Life Science and The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, P.R. China.

The study was designed to investigate the effects of cryopreservation on bovine, ovine, and goat sperm motility, acrosome structure, enzyme activity, and fertilization ability. Percentage of sperm with hyaluronidase enzyme (HYD) activity was detected by a modified sodium hyaluronate-gelatin membrane. The N-α-benzoyl-DL-arginine-p-nitroanilide (BNPNA) method was used to assess the sperm acrosome enzyme (ACE). The mean percentage of sperm acrosome integrity dropped significantly ( < 0.01) after cryopreservation. The ACE activity of bovine sperm (100.48) was higher ( < 0.01) than that of ovine (57.88) or goat sperm (50.30), while the percentage of sperm with HYD activity of bovine (71.10%) and ovine (67.60%) sperm was higher than that of goat sperm (58.52%) after cryopreservation ( < 0.01). Sperm motility was positively correlated with the activity of the two acrosome enzymes before and after cryopreservation ( < 0.01). Cryopreservation had a negative effect on acrosomal morphology, motility, and acrosomal enzyme activity in their sperm. The fertilization ability of ovine and goat sperm decreased significantly after cryopreservation, but that of frozen bovine sperm did not differ significantly when compared with fresh sperm. There was no significant difference between ovine and goat sperm indices, except for percentage of sperm with HYD activity.
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http://dx.doi.org/10.1590/1984-3143-ar2020-0219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159072PMC
March 2021

Beneficial effects of Dendrobium officinale on metabolic hypertensive rats by triggering the enteric-origin SCFA-GPCR43/41 pathway.

Food Funct 2021 Jun 18;12(12):5524-5538. Epub 2021 May 18.

Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China.

Given the increasing global trend toward unhealthy lifestyles and dietary decisions, such as "over-consumption of alcohol, and high sugar and fat diets" (ACHSFDs), it is not surprising that metabolic hypertension (MH) is now the most common type of hypertension. There is an urgent, global need for effective measures for the prevention and treatment of MH. Improper diet leads to decreased short-chain fatty acid (SCFA) production in the gut, leading to decreased gastrointestinal function, metabolism, and blood pressure as a result of signaling through G-protein-coupled receptors (GPCRs), ultimately causing MH. Previous studies have suggested that Dendrobium officinale (DO) may improve gastrointestinal function, lower blood pressure, and regulate metabolic abnormalities, but it is not clear whether it acts on MH by increasing SCFA and, if so, how. In this research, it was observed that Dendrobium officinale ultrafine powder (DOFP) could lower blood pressure and improve lipid abnormalities in ACHSFD-induced MH model rats. Moreover, DOFP was found to improve the intestinal flora and increased the SCFA level in feces and serum, as well as increased the expressions of GPCR43/41 and eNOS and the nitric oxide (NO) level. An experiment on isolated aorta rings revealed that DOFP improved the vascular endothelial relaxation function in MH rats, and this effect could be blocked by the eNOS inhibitor l-NAME. These experimental results suggest that DOFP improved the intestinal flora and increased the production, transportation, and utilization of SCFA, activated the intestinal-vascular axis SCFA-GPCR43/41 pathway, improved vascular endothelial function, and finally lowered blood pressure in MH model rats. This research provides a new focus for the mechanism of the effect of DOFP against MH by triggering the enteric-origin SCFA-GPCR43/41 pathway.
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http://dx.doi.org/10.1039/d0fo02890hDOI Listing
June 2021

Temporal mode properties of Raman scattering in optical fibers.

Opt Express 2021 Apr;29(9):13408-13415

By investigating the intensity correlation function, we study the temporal mode properties of spontaneous Raman photons generated in single mode fibers pumped by short pulses. We find that the intensity correlation function of the Raman photons is related to the dispersion induced temporal mismatch among the Raman photons generated in different subparts of the fiber. When no temporal mismatch exists, the intensity correlation function only depends on the ratio between the pulse width of the pump and the coherence time of the Raman photons. With the ratio decreasing, the intensity correlation function increase. Our study is helpful for easily creating high-quality true thermal light which will be a useful resource for second-order coherence based remote sensing.
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http://dx.doi.org/10.1364/OE.421222DOI Listing
April 2021

[Effect of Dendrobium officinale on Yin deficiency constipation induced by warm-drying medicine in mice].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1674-1680

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobium officinale is a sacred product for nourishing Yin and has a clear "thick gastrointestinal" effect. Modern pharmacological studies had found that it could improve gastrointestinal function. This study observed the improvement effect of D. officinale on constipation model mice with Yin deficiency caused by warm-drying medicine. It provided experimental basis for the treatment of Yin deficiency constipation. The male and female ICR mice were randomly divided into normal group, model group, D. officinale high, medium and low dose groups(0.6, 0.4, 0.2 g·kg~(-1)), and phenolphthalein tablets group. The model mice of Yin deficiency constipation were established by gavage with warm-drying medicine. The overall state and body temperature of the mice were observed and recorded. The number of feces, feces weight, fecal moisture content and intestinal propulsion were measured. The morphological damage of colon tissue was observed by hematoxylin-eosin(HE) staining. The expression of inducible nitric oxide synthase(iNOS) in the colon was detected by Western blot and immunohistochemical method. The expression of iNOS mRNA in the colon was detected by Real-time fluorescence quantitative PCR, and the serum cyclic guanosine phosphate(cGMP) level was detected the enzyme-linked immunosorbent assay(ELISA). The results showed that D. candidum could reduce the body temperature of mice with Yin deficiency constipation, increase the number of feces, wet feces, dry feces and intestinal propulsion ability, reduce the expression of iNOS protein and mRNA in the colon, and reduce the content of cGMP in the serum. It showed that D. candidum could improve the symptoms of Yin deficiency constipation mice caused by warm-drying medicine, and the mechanism may be related to reducing the expression of iNOS in the colon and increasing intestinal motility.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200104.402DOI Listing
April 2021

[Protective effects of Dendrobium officinale superfine powder against LPS-induced intestinal mucosal injury in mice].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1667-1673

Zhejiang Chinese Medical University Hangzhou 310053, China.

This study aims to investigate the preventive effect of Dendrobium officinale in LPS-induced intestinal mucosal damage. Forty SPF-grade C57 BL/6 J male mice were randomly divided into normal group(NC), model group(LPS), and two superfine powder groups of Dendrobium officinale(DOF)(DOF-L, 0.30 g·kg~(-1)and DOF-H, 0.60 g·kg~(-1), respectively), with 10 mice in each group. DOF superfine powder suspension was given via oral administration to mice for 7 days, while the mice in NC and LPS groups received the same volume of saline for 7 days. On the eighth day, the mice in LPS group and DOF treatment groups were injected with LPS(5 mg·kg~(-1)) by intraperitoneal injection to establish the intestinal mucosal injury model, while the mice in NC group were injected with the same volume of sterile saline in the same manner. Six hours after injection with LPS or saline, plasma and the intestinal tissue were collected. The diamine oxidase(DAO) and D-lactate levels in plasma were detected with a biochemical method. The levels of proinflammatory factors interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in plasma were detected by ELISA. The histomorphology and ultrastructure of mouse ileum tissues were observed by hematoxylin-eosin(HE) staining in optical microscope and transmission electron microscope(TEM). The expression and distribution of tight junction(TJ) proteins claudin-1, occludin and F4/80 were detected by immunohistochemistry while the protein expression levels of Toll-like receptor 4(TLR-4) and nuclear factor kappa B p65(NF-κB p65) in jejunum were detected by Western blot. The experimental results showed that continuous intragastric administration of D. officinale superfine powder for 7 days obviously alleviated the damage and ultrastructural changes of intestinal mucosa induced by LPS; significantly decreased DAO and D-lactate levels in plasma in model group(P<0.05); up-regulated the protein expression of claudin-1 and occludin in ileum tissues; down-regulated the protein expression of TLR-4 and NF-κB p65 in jejunum tissues(P<0.01); significantly decreased TNF-α and IL-6 levels in plasma(P<0.05); and decreased the infiltration of F4/80~+ macrophage cells. Our results suggested that D. officinale had significant protective effects on LPS-induced intestinal mucosal damage and reduced intestinal permeability. The mechanism might be related to its effects of inhibiting inflammation via TLR-4/NF-κB p65, and up-regulating the expression of tight junction proteins.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20201228.401DOI Listing
April 2021

[Effect of Dendrobii officinalis superfine powder on overeating greasy-induced metabolic hypertension in rats].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1658-1666

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobii officinalis, with a definite effect of nourishing Yin and clearing heat, has been a folk habit for drinking after being mixed with water. Because its superfine powder has the advantages of high dissolution and convenient drinking, we observed the effect of D. officinalis superfine powder on metabolic hypertension model rats and its possible mechanism in this experiment, which can be used as a reference for its clinical application for hypertension. The overeating greasy-induced metabolic hypertension model was established with high-fat, high-sugar and high-purine diet. These rats were orally administered with 400 mg·kg~(-1) and 200 mg·kg~(-1) of D. officinalis superfine powder for 20 consecutive weeks. During this period, blood pressure, blood lipid, blood glucose, insulin and other related indexes of glucose and lipid metabolism were monitored; the levels of lipopolysaccharide(LPS), C-reactive protein(CRP), interleukin 6(IL-6) and other inflammatory mediators were measured; the levels of nitric oxide(NO) and endothelin-1(ET-1) were detected, and the histomorphological and ultrastructural changes of aorta were observed. In addition, the expression of LPS/TLR4 pathway-related molecules in aorta was determined. The results showed that long-term administration of D. officinalis superfine powder significantly reduced the levels of systolic blood pressure(SBP), diastolic blood pressure(DBP) and mean arterial pressure(MBP) in metabolic hypertension model rats, decreased the levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-c), glucose(Glu), and insulin(INS) levels in blood, increased the contents of high density lipoprotein cholesterol(HDL-c),decreased the LPS, CRP, IL-6 and ET-1 levels in blood and increased NO content. Furthermore, it improved the abnormality of aortic histomorphology and endothelial ultrastructure, and inhibited the protein expression of TLR4, myeloid differentiation factor(MyD88), IL-6, interleukin-1 β(IL-1β), and tumor necrosis factor-α(TNF-α) as well as mRNA expression of TNF-α and IL-1β in aorta. In conclusion, D. officinalis superfine powder may improve the abnormal function and structure of blood vessels by inhibiting the activation of LPS/TLR4 pathway, thus playing a role against metabolic hypertension.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20201027.403DOI Listing
April 2021

[Effect of Dendrobium officinale superfine powder on stomach Yin deficiency model mice induced by "spicy overeating"].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1651-1657

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobium officinale is a traditional Chinese medicine for nourishing Yin and benefiting stomach. Its superfine powder has many advantages, such as good dissolution, high utilization rate, strong integrity and easy to use. However, the researches on effect of D. officinale superfine powder on stomach Yin deficiency model are still not sufficient. In this experiment, we explored the effect of D. officinale superfine powder in mice model with stomach Yin deficiency caused by "spicy overeating", and provided certain reference value for its application in gastrointestinal diseases. Male ICR mice were randomly divided into normal group, model group, Yiweitang group, omeprazole group, and D. officinale superfine powder high, medium and low dose groups. The mixture of wine and pepper liquid was given by gavage administration for 30 d, and the corresponding drug was given for 60 d while the model was conti-nued. The body weight, food intake, water intake, fecal moisture content and particle number, foot temperature of mice were measured. The levels of serum gastrin(Gas), motilin(MTL) and somatostatin(SS) were measured by ELISA. Gastric histomorpho-logy was observed by HE staining. The expression levels of nuclear factor kappa B(NF-κB) and cyclooxygenase-2(COX-2) were determined by immunohistochemistry. The expression levels of B-cell lymphoma-2(Bcl-2) and Bcl-2 associated X protein(Bax) in gastric tissues were detected by Western blot. The results showed that D. officinale superfine powder could increase the food intake, water intake, fecal moisture content and particle number, reduce the foot temperature, improve the pathological changes of gastric mucosa, reduce the expression of NF-κB, COX-2 protein in gastric tissues, and increase the ratio of Bax/Bcl-2. D. officinale superfine powder can "nourish Yin and benefit the stomach", improve the syndrome of stomach Yin deficiency, such as "hunger but not want to eat, dry mouth but not want to drink, hand and feet hot, constipation", and reduce the damage of gastric mucosa. The mechanism may be related to regulating the secretion of gastrointestinal hormones, inhibiting the inflammation of gastric tissues and promoting the apoptosis of abnormal cells in gastric tissues.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200810.403DOI Listing
April 2021
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