Publications by authors named "Jie Ma"

1,427 Publications

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Structural white matter alterations in carpal tunnel syndrome: A modified TBSS study.

Brain Res 2021 Jun 8:147558. Epub 2021 Jun 8.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Functional and structural brain alterations have been noted in carpal tunnel syndrome (CTS), the most common entrapment peripheral neuropathy. Previous studies were mainly focused on somatosensory cortices. However, the changes of white matter diffusion properties in nonsensorimotor cortices remain uninvestigated. We utilized a modified tract-based spatial statistics (TBSS) pipeline to explore CTS-related white matter plasticity, omitting the skeletonization step and registering diffusion tensor imaging (DTI) data to a study-specific, high resolution T1 template by an optimized registration method. The modified TBSS was demonstrated to be more sensitive to detect changes in white matter integrity than the standard TBSS approach. In this study, 25 moderate/severe CTS patients and 17 age- and sex-matched healthy controls (HC) were evaluated with DTI. Fractional anisotropy (FA) and radial diffusivity (RD) were calculated for group comparison. And the relationship between diffusion parameters and clinical assessments was also analyzed. Comparing with the healthy controls, CTS patients showed significantly increased FA and decreased RD in areas of multisensory integration and motor control involving the central opercular cortex and supplementary motor area (SMA) of the dominant hemisphere. Moreover, altered diffusion parameters in the central opercular cortex of the dominant hemisphere were significantly correlated with Boston Carpal Tunnel Questionnaire (BCTQ) scores. It is considered to be a form of maladaptive neuroplastic response to CTS-associated afference and motor control deficits. Such insight may be helpful in developing new strategies for the treatment of CTS.
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http://dx.doi.org/10.1016/j.brainres.2021.147558DOI Listing
June 2021

Efficient removal of bisphenol S by non-radical activation of peroxydisulfate in the presence of nano-graphite.

Water Res 2021 May 26;201:117288. Epub 2021 May 26.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.

An environmentally friendly and efficient catalyst is important for the persulfate activation and pollutants removal from water. In this study, nano-graphite (NG) prepared by detonation method, was firstly applied as the superb carbon catalyst to activate peroxydisulfate (PDS) for the degradation of bisphenol S (BPS) via a non-radical pathway. Results showed that NG had a very high catalytic performance and degraded most of BPS within 20.0 min, out-performing many popular metal-based catalysts. The doped N atoms (i.e. graphitic N and pyridinic N) in NG were identified as the possible reactive sites for the PDS activation. It is proposed that PDS could form the metastable surface-bound PDS complexes on the NG surface, which promoted the BPS degradation. The NG/PDS system had a strong anti-interference ability for the environmental background substances and a wide operative pH range, so it had a good application prospect in the actual wastewater environment. This study not only provides an efficient method for the removal of bisphenol pollutants, but also deepens the insight into the reaction mechanisms.
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http://dx.doi.org/10.1016/j.watres.2021.117288DOI Listing
May 2021

Phosphorus transport in different soil types and the contribution of control factors to phosphorus retardation.

Chemosphere 2021 Aug 9;276:130012. Epub 2021 Mar 9.

Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin, 300191, China; College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, China.

Iron (Fe) minerals, organic matter (OM), and pH can effectively regulate phosphorus (P) transport in the soil. However, their respective contributions in this regard are still unclear. In this study, P transport in soil columns was investigated by monitoring breakthrough curves and transport model fitting, and the contributions of Fe and total organic carbon (TOC) concentrations, as well as pH to P retention, were determined using multiple linear regression (MLR). The results showed that the rate of P transport in Fe-rich laterite soil was significantly lower (retardation factor R = 458.5) than that in the other soil types (R = 108.4-247.6). Additionally, it was observed that OM formed rate-limited adsorption sites, causing the rapid release of labile P, and owing to P release and readsorption. Even though more significant P releases were observed, chernozem soil had an obvious inhibiting effect on P transport owing to its relatively high Fe content, and the high P-Fe increment (48.9-90.4%) indicated the essential role of Fe minerals in P immobilization. Further, P was readily transported in natural or artificially modified fluvo-aquic soils with high calcium concentrations, and it was also observed that the convection-dispersion equation (CDE) and Thomas models were suitable for describing P retardation and adsorption, respectively. Furthermore, the contribution weights of Fe and TOC concentrations as well as pH to P retardation, based on MLR calculations, were approximately 1.0, -0.3, and -0.2, respectively. Our findings can support the control of eutrophication pollution caused by P leaching.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130012DOI Listing
August 2021

Enhanced adsorption of polystyrene nanoplastics (PSNPs) onto oxidized corncob biochar with high pyrolysis temperature.

Sci Total Environ 2021 Aug 16;784:147115. Epub 2021 Apr 16.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, PR China; College of Resource and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou, Jiangxi 341000, PR China.

Plastic pollution has become a global threat in the natural environment, and an urgent remedial measure is needed to reduce the negative effects caused by plastic pollutants. In the current study, the effects of pyrolysis temperature (500 °C, 700 °C, and 900 °C) and aging on the adsorption of polystyrene nanoplastics (PSNPs) onto corncob biochar were systematically assessed with kinetic, isotherm, pH-dependent adsorption experiments, FTIR and XPS spectroscopy, and DLVO calculations. The oxidation was done with 5% of HNO/HSO to simulate long-term oxidative aging of biochar in the environment. The results showed that the specific surface area, hydrophobicity, and aromaticity of biochar increased with pyrolysis temperature, whereas the specific surface area and amounts of oxygen-containing groups increased after oxidation. The adsorption mechanism of PSNPs onto the biochar was explored based on the correlation between biochar properties and adsorption parameters derived from adsorption isotherms. Overall, the adsorption capacity of biochar for PSNPs increased with increased pyrolysis temperature and after aging. While the increase of specific surface area was considered the major factor leading to the increase of the adsorption, the variation in surface properties also played an important role. Pore filling, hydrophobic interaction, and hydrogen bonding may all be involved in PSNPs adsorption to biochar. However, the hydrophobic interaction might be more important for the fresh biochar, whereas hydrogen bonding involving oxygen-containing groups might make a bigger contribution to PSNPs adsorption to oxidized biochar. The pH experiments revealed that PSNPs adsorption decreased in general with the increase of pH, indicating that electrostatic repulsion played a vital role in the PSNPs adsorption process. The results of this study indicate that biochar can be potentially applied to immobilize plastic particles in terrestrial ecosystems such as in soil or groundwater, and the immobilization could be enhanced via artificial oxidation or aging of biochar in the natural environment.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147115DOI Listing
August 2021

Irrelevant task suppresses the N170 of automatic attention allocation to fearful faces.

Sci Rep 2021 Jun 3;11(1):11754. Epub 2021 Jun 3.

School of Psychology, Chengdu Medical College, Chengdu, 610500, China.

Recent researches have provided evidence that stimulus-driven attentional bias for threats can be modulated by top-down goals. However, it is highlight essential to indicate whether and to what extent the top-down goals can affect the early stage of attention processing and its early neural mechanism. In this study, we collected electroencephalographic data from 28 healthy volunteers with a modified spatial cueing task. The results revealed that in the irrelevant task, there was no significant difference between the reaction time (RT) of the fearful and neutral faces. In the relevant task, we found that RT of fearful faces was faster than that of neutral faces in the valid cue condition, whereas the RT of fearful faces was slower than that of neutral faces in the invalid cue condition. The N170 component in our study showed a similar result compared with RT. Specifically, we noted that in the relevant task, fearful faces in the cue position of the target evoked a larger N170 amplitude than neutral faces, whereas this effect was suppressed in the irrelevant task. These results suggest that the irrelevant task may inhibit the early attention allocation to the fearful faces. Furthermore, the top-down goals can modulate the early attentional bias for threatening facial expressions.
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http://dx.doi.org/10.1038/s41598-021-91237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175742PMC
June 2021

Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers.

Signal Transduct Target Ther 2021 06 3;6(1):216. Epub 2021 Jun 3.

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.

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http://dx.doi.org/10.1038/s41392-021-00612-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173321PMC
June 2021

A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells.

Nat Cell Biol 2021 Jun 31;23(6):642-651. Epub 2021 May 31.

The Institute for Advanced Studies, Wuhan University, Wuhan, China.

In the last decade, DNA-based tension sensors have made significant contributions to the study of the importance of mechanical forces in many biological systems. Albeit successful, one shortcoming of these techniques is their inability to reversibly measure receptor forces in a higher regime (that is, >20 pN), which limits our understanding of the molecular details of mechanochemical transduction in living cells. Here, we developed a reversible shearing DNA-based tension probe (RSDTP) for probing molecular piconewton-scale forces between 4 and 60 pN transmitted by cells. Using these probes, we can easily distinguish the differences in force-bearing integrins without perturbing adhesion biology and reveal that a strong force-bearing integrin cluster can serve as a 'mechanical pivot' to maintain focal adhesion architecture and facilitate its maturation. The benefits of the RSDTP include a high dynamic range, reversibility and single-molecule sensitivity, all of which will facilitate a better understanding of the molecular mechanisms of mechanobiology.
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http://dx.doi.org/10.1038/s41556-021-00691-0DOI Listing
June 2021

Increased proportion of Th17/Treg cells at the new diagnosed stage of chronic immune thrombocytopenia in pediatrics: the pilot study from a multi-center.

Eur J Pediatr 2021 May 27. Epub 2021 May 27.

Hematology & Oncology Center, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China.

Chronic immune thrombocytopenia (CITP) is an autoimmune disease with many immune dysfunctions, including T helper type 17 cell (Th17)/regulatory T cells (Tregs) imbalance. Low quality of life and side effects of drugs are severe, especially in pediatrics. This study aimed to determine Th17/Treg polarization in pediatric CITP when first diagnosing ITP and evaluate its use as a predictive marker for pediatric CITP. This was a pilot study from a multi-center. Setting the effective data size to 100 patients, data entry ended in the 142nd patient who had completed a 1-year follow-up. The percentages of Treg cells and Th17 cells were quantified by flow cytometry when new diagnosed ITP patients first arrived. The association between the Th17/Treg ratio and CITP was analyzed statistically. The percentages of Treg cells and Th17 cells were lower (P = 0.0008) and higher (P = 0.0001), respectively, in the CITP-outcome group compared with the remission group. The receiver operating characteristic analysis showed that the area under the curve (AUC) of Treg and Th17 cells was 0.811 and 0.834, respectively. The ratio of Th17/Treg exhibited the largest AUC of 0.897 (cutoff value 0.076).Conclusions: Thus, the percentage of Th17 /Treg ratio of pediatric CITP is elevated at new diagnosed ITP stage. It is a promising predictive marker for the development of CITP to some extent.Trial registration: ChiCTR1900022419 (10 April 2019) What is Known: • The percentage of Th17 /Treg ratio of pediatric CITP is elevated. What is New: • This study shows that the percentage of Th17 /Treg ratio of pediatric CITP is elevated at new diagnosed ITP stage. This work may provide a new point for pediatric CITP's prediction. The imbalanced ratio of Th17/Treg was obvious when first diagnose ITP in pediatric CITP patients, rendering them as potential predictive tools for discriminating CITP to facilitate with the management of pediatric patient care. In addition, the combination of them may serve as a predictive marker in pediatric CITP.
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http://dx.doi.org/10.1007/s00431-021-04121-zDOI Listing
May 2021

Identification of :c.5470_5477del as a Founder Mutation in Chinese Ovarian Cancer Patients.

Front Oncol 2021 11;11:655709. Epub 2021 May 11.

Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.

Predisposition of germline mutations ( ) increases the risk of breast and ovarian cancer in females, but the mutation prevalence and spectrum are highly ethnicity-specific with different recurrent mutations being reported in different populations. Hereby, we performed hybridization-based target sequencing of in 530 ovarian cancer patients from Henan, the central region of China, followed by haplotype analysis of six short tandem repeat (STR) markers in the patients with recurrent mutations to determine their founder effect. About 28.3% (150/530) of the OC patients in our cohort harbored ; of the 151 mutations, 117 in and 34 in , identified in this study, :c.5470_5477del, c.981_982del, and c.4065_4068del are the top three mutants, recurrently detected in eight, seven, and six independent patients respectively. Haplotype analysis identified a region of 0.6 MB genomic length covering highly conserved across all eight carriers of :c.5470_5477del, but not c.981_982del, suggesting a consequence of founder effect. Retrospective analysis in a subgroup of serous ovarian cancer patients revealed status was not associated with the progression-free survival (PFS); instead, an expression of Ki-67% ≥50% was associated with a shorter PFS ( = 0.041). In conclusion, patients with pathogenic or likely pathogenic account for 28.3% of the OC cases from Henan, and :c.5470_5477del, the most frequently detected mutation in Henan patients, is a founder mutation in the population.
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http://dx.doi.org/10.3389/fonc.2021.655709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148338PMC
May 2021

Organically-bound silicon enhances resistance to enzymatic degradation and nanomechanical properties of rice plant cell walls.

Carbohydr Polym 2021 Aug 30;266:118057. Epub 2021 Apr 30.

Institut für Mineralogie, University of Münster, 48149, Münster, Germany; School of Molecular and Life Science, Curtin University, 6845, Perth, Australia.

Plant cell walls exhibit excellent mechanical properties, which form the structural basis for sustainable bioresources and multifunctional nanocelluloses. The wall nanomechanical properties of living cells through covalent modifications of hybrid inorganic elements, such as silicon, may confer significant influence on local mechano-response and enzymatic degradation. Here, we present a combination of ex situ measurements of enzyme-released oligosaccharide fragments using MALDI-TOF MS and in situ atomic force microscopy (AFM) imaging through PeakForce quantitative nanomechanical mapping of tip-functionalized single-molecule enzyme-polysaccharide substrate recognition and the nanoscale dissolution kinetics of individual cellulose microfibrils of living rice (Oryza sativa) cells following silicate cross-linking of cell wall xyloglucan. We find that xyloglucan-bound silicon enhances the resistance to degradation by cellulase and improves the wall nanomechanical properties in the elastic modulus at the single-cell level. The findings establish a direct link between an inorganic element of silicon and the nanoscale architecture of plant cell wall materials for sustainable utilization.
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http://dx.doi.org/10.1016/j.carbpol.2021.118057DOI Listing
August 2021

Circular RNA circ_ASAP2 regulates drug sensitivity and functional behaviors of cisplatin-resistant gastric cancer cells by the miR-330-3p/NT5E axis.

Anticancer Drugs 2021 May 19. Epub 2021 May 19.

Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying, China.

This study aims to explore the biological actions of circular RNA (circRNA) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (circ_ASAP2, circ_0006089) in cisplatin (DDP) resistance of gastric cancer. Circ_ASAP2, ecto-5'-nucleotidase (NT5E) and miR-330-3p were quantified by quantitative real-time PCR or western blot. The measurements of the IC50 value and cell proliferation were done using 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Cell colony formation, cell cycle distribution, apoptosis, migration and invasion were evaluated by the colony formation, flow cytometry and transwell assays. Dual-luciferase reporter assay was performed to confirm the targeted relationship between different molecules. The role of circ_ASAP2 in tumor growth was gauged by in vivo animal studies. Circ_ASAP2 and NT5E were overexpressed in DDP-resistant gastric cancer tissues and cells. Knockdown of circ_ASAP2 promoted DDP sensitivity, apoptosis and repressed proliferation, migration and invasion of DDP-resistant gastric cancer cells in vitro and diminished tumor growth in vivo. Moreover, NT5E was a downstream effector of circ_ASAP2 in regulating cell DDP sensitivity and functional behaviors. Mechanistically, circ_ASAP2 directly bound to miR-330-3p to promote NT5E expression. Furthermore, circ_ASAP2 modulated cell DDP sensitivity and functional behaviors by targeting miR-330-3p. Knockdown of circ_ASAP2 promoted DDP sensitivity and suppressed malignant behaviors of DDP-resistant gastric cancer cells through targeting the miR-330-3p/NT5E axis.
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http://dx.doi.org/10.1097/CAD.0000000000001087DOI Listing
May 2021

Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue.

J Mol Neurosci 2021 May 16. Epub 2021 May 16.

College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

In recent years, the incidence of fatigue has been increasing, and the effective prevention and treatment of fatigue has become an urgent problem. As a result, the genetic research of fatigue has become a hot spot. Transcriptome-level regulation is the key link in the gene regulatory network. The transcriptome includes messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). MRNAs are common research targets in gene expression profiling. Noncoding RNAs, including miRNAs, lncRNAs, circRNAs and so on, have been developed rapidly. Studies have shown that miRNAs are closely related to the occurrence and development of fatigue. MiRNAs can regulate the immune inflammatory reaction in the central nervous system (CNS), regulate the transmission of nerve impulses and gene expression, regulate brain development and brain function, and participate in the occurrence and development of fatigue by regulating mitochondrial function and energy metabolism. LncRNAs can regulate dopaminergic neurons to participate in the occurrence and development of fatigue. This has certain value in the diagnosis of chronic fatigue syndrome (CFS). CircRNAs can participate in the occurrence and development of fatigue by regulating the NF-κB pathway, TNF-α and IL-1β. The ceRNA hypothesis posits that in addition to the function of miRNAs in unidirectional regulation, mRNAs, lncRNAs and circRNAs can regulate gene expression by competitive binding with miRNAs, forming a ceRNA regulatory network with miRNAs. Therefore, we suggest that the miRNA-centered ceRNA regulatory network is closely related to fatigue. At present, there are few studies on fatigue-related ncRNA genes, and most of these limited studies are on miRNAs in ncRNAs. However, there are a few studies on the relationship between lncRNAs, cirRNAs and fatigue. Less research is available on the pathogenesis of fatigue based on the ceRNA regulatory network. Therefore, exploring the complex mechanism of fatigue based on the ceRNA regulatory network is of great significance. In this review, we summarize the relationship between miRNAs, lncRNAs and circRNAs in ncRNAs and fatigue, and focus on exploring the regulatory role of the miRNA-centered ceRNA regulatory network in the occurrence and development of fatigue, in order to gain a comprehensive, in-depth and new understanding of the essence of the fatigue gene regulatory network.
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http://dx.doi.org/10.1007/s12031-021-01845-3DOI Listing
May 2021

Study on potential energy curves and ro-vibrational energies of DT, HT and T molecules.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Nov 5;260:119913. Epub 2021 May 5.

State Key Laboratory of Quantum Optics and Quantum Optics Devices, Laser Spectroscopy Laboratory, College of Physics and Electronics Engineering, Shanxi University, Taiyuan 030006, China.

Accurately monitoring and effectively controlling the tritium compounds based on their ro-vibrational energy structure are important issues in various nuclear systems. Because of their radioactivity, it is difficult to obtain the corresponding energies directly through experiments. In this paper, the potential energy curves and the corresponding ro-vibrational full spectrum of DT, HT and T systems are derived by ab initio methods. However, it is difficult to verify the reliability of the calculated results due to the lack of direct experimental support. Therefore, a data-driven reliability analysis method is proposed, which can confirm the reliability by extracting information from the relevant calculations and multiple experimental data (the vibrational level, rotational level, and molar heat capacity) of similar systems (HD, H, D). The results show that: 1) The potential energy curves obtained by the ab initio method can provide the full ro-vibrational energy spectrum with an accuracy of approximately 10 cm; 2) Macroscopic heat capacity information can be used to distinguish and calibrate the overall reliability of microscopic ro-vibrational energies; 3) For the isotopic energy level structure of hydrogen, the influence of isotopes is mainly mass effect.
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http://dx.doi.org/10.1016/j.saa.2021.119913DOI Listing
November 2021

Sub-five-optical-cycle pulse generation from a Kerr-lens mode-locked Yb:CaYAlO laser.

Opt Lett 2021 May;46(10):2328-2331

Direct generation of ultrashort few-optical-cycle pulses in various wavelength regions has attracted great attention in recent decades. In this paper, generation of less than five-optical-cycle pulses from a Kerr-lens mode-locked ${\rm Yb}{:}{\rm CaYAlO}_4$ laser is demonstrated. Pumped by a 976 nm fiber laser, stable near-Fourier-transform-limited ultrashort soliton pulses centered around 1080 nm with a repetition rate of ${\sim}{113.7}\;{\rm MHz}$ were obtained. The obtained pulses have a pulse duration as short as 17 fs if a ${{\rm Sech}^2}$-shaped pulse profile is assumed, corresponding to about 4.68 optical cycles. To the best of our knowledge, this is the shortest pulse directly generated from mode-locked rare-earth-doped solid-state oscillators.
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http://dx.doi.org/10.1364/OL.424846DOI Listing
May 2021

Hybrid evaporative cooling of Cs atoms to Bose-Einstein condensation.

Opt Express 2021 Apr;29(9):13960-13967

The Bose-Einstein condensation (BEC) of Cs atoms offers an appealing platform for studying the many-body physics of interacting Bose quantum gases, owing to the rich Feshbach resonances that can be readily achieved in the low magnetic field region. However, it is notoriously difficult to cool Cs atoms to their quantum degeneracy. Here we report a hybrid evaporative cooling of Cs atoms to BEC. Our approach relies on a combination of the magnetically tunable evaporation with the optical evaporation of atoms in a magnetically levitated optical dipole trap overlapping with a dimple trap. The magnetic field gradient is reduced for the magnetically tunable evaporation. The subsequent optical evaporation is performed by lowering the depth of the dimple trap. We study the dependence of the peak phase space density (PSD) and temperature on the number of atoms during the evaporation process, as well as how the PSD and atom number vary with the trap depth. The results are in excellent agreement with the equation model for evaporative cooling.
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http://dx.doi.org/10.1364/OE.419854DOI Listing
April 2021

Simultaneous measurement of temperature and relative humidity based on a twisted microfiber coated with nanomaterials.

Appl Opt 2021 May;60(13):3849-3855

We propose a twisted microfiber interferometer sensor coated with boron nitride (BN) nanosheets for simultaneous measurement of relative humidity (RH) and temperature ($ T $). Sensitive material characteristics (BN nanosheets) enhance refractive index (RI) sensing sensitivity of proposed devices. A twisting process on the microfiber surely improves the evanescent field interaction with the deposited layer. The experimental results show that the RH sensitivities are ${-}{121.6}\;{\rm pm}/\% {\rm RH}$ and 0.26 dBm/%RH for humidity range from 46% to 72% and $ T $ sensitivities of 23.5 pm/°C and ${-}{0.045}\;{\rm dBm}/^\circ {\rm C}$ from 50°C to 90°C. The twisted microfiber interferometer has the advantages of compact structure, high sensitivity, and multiparameter measurement, which has certain potential for more applications.
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http://dx.doi.org/10.1364/AO.423341DOI Listing
May 2021

Multi-level height maps-based registration method for sparse LiDAR point clouds in an urban scene.

Appl Opt 2021 May;60(14):4154-4164

The LiDAR sensor has been widely used for reconstruction in urban scenes. However, the current registration method makes it difficult to find stable 3D point correspondences from sparse and low overlapping LiDAR point clouds. In the urban situation, most of the LiDAR point clouds have a common flat ground. Therefore, we propose a novel, to the best of our knowledge, multi-level height (MH) maps-based coarse registration method. It requires that source and target point clouds have a common flat ground, which is easily satisfied for LiDAR point clouds in urban scenes. With MH maps, 3D registration is simplified as 2D registration, increasing the speed of registration. Robust correspondences are extracted in MH maps with different height intervals and statistic height information, improving the registration accuracy. The solid-state LiDAR Livox Mid-100 and mechanical LiDAR Velodyne HDL-64E are used in real-data and dataset experiments, respectively. Verification results demonstrate that our method is stable and outperforms state-of-the-art coarse registration methods for the sparse case. Runtime analysis shows that our method is faster than these methods, for it is non-iterative. Furthermore, our method can be extended for the unordered multi-view point clouds.
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http://dx.doi.org/10.1364/AO.419746DOI Listing
May 2021

[Identification techniques of small molecule drug target proteins without chemical modification and its applications: a review].

Authors:
Jie Ma Qiang Liu

Sheng Wu Gong Cheng Xue Bao 2021 Apr;37(4):1131-1138

Department of Histoembryology, Genetics and Developmental Biology, Basic Medical College, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Identification of the target proteins of small molecule drugs is crucial for understanding the mechanisms of drug actions and its side effects. Conventional methods require chemical modification, which might alter the activities of the drugs. Various label-free techniques have been developed to identify drug target proteins without chemical modifications. This includes drug affinity responsive target stability (DARTS), stability of proteins from rates of oxidation (SPROX), cellular thermal shift assay (CETSA), thermal proteome profiling (TPP) and many others. Here we review the principles and applications of these label-free techniques, their advantages and limitations, as well as the most recent advances.
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http://dx.doi.org/10.13345/j.cjb.200426DOI Listing
April 2021

Comparison of the effects of large-grained and nano-sized biochar, ferrihydrite, and complexes thereof on Cd and As in a contaminated soil-plant system.

Chemosphere 2021 Apr 30;280:130731. Epub 2021 Apr 30.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, China; College of Resource and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou, Jiangxi, 341000, China.

Cd and As are difficult to co-remediate in co-contaminated soils. In this study, remediation materials comprising large-grained and nano-sized biochar (BC), ferrihydrite (FH), and complexes thereof were added to Cd- and As-contaminated soil. The uptake of Cd and As by pak choi (Brassica chinensis L.) was then evaluated using a pot experiment and the Cd and As concentrations of the soil pore water and leaching water were measured. The Cd and As concentrations of the pore and leaching water were slightly increased with the addition of BC, and decreased with addition of FH and the biochar-ferrihydrite complex (BC-FH). However, nano-sized BC (BC), FH (FH), and BC-FH (BC-FH) had little influence on the decreases in Cd and As of the two monitored water types. Large-grained remediation materials, rather than nanomaterials, decreased the Cd and As concentrations of the two monitored water types. Nonetheless, nanomaterial treatments more effectively decreased the Cd and As concentrations in plants by an average of >10% relative to the large-grained treatments. The DLVO theory analysis suggested that BC, FH, and BC-FH, immobilized in the topsoil, adsorbed heavy metals in the rhizosphere soil. The remainder of the nano-sized materials was dispersed in the rhizosphere soil pores, shielding the uptake of Cd and As by the roots. Although the doses of nanomaterials used in this study were less than one-fortieth of those of the large-grained materials, changes in the plant rhizosphere microenvironment caused by the nanomaterials decreased the risk of toxicity transfer from the soil to the plants.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130731DOI Listing
April 2021

Competitive adsorption of Dibutyl phthalate (DBP) and Di(2-ethylhexyl) phthalate (DEHP) onto fresh and oxidized corncob biochar.

Chemosphere 2021 Apr 23;280:130639. Epub 2021 Apr 23.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, PR China; College of Resource and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou Jiangxi, 341000, PR China.

Phthalates (PAEs) often exist simultaneously in contaminated soil and wastewater systems, and their adsorption to biochar might impact their behavior in the environment. So far, the competitive adsorption of PAEs to biochar has not been reported. In this study, the competitive adsorption of Dibutyl phthalate (DBP) and Di(2-ethylhexyl) phthalate (DEHP) on corncob biochar (fresh and oxidized) was investigated, and experiments of kinetics, isotherms, and thermodynamics were conducted. Langmuir and Freundlich models, pseudo-first-order and second-order kinetic models were used to simulate the experimental data. In the mono PAEs component systems, the biochar showed significantly greater adsorption capacity for DEHP (11.8-16.16 mg g) than for DBP (9.86-13.2 mg g). The oxidized biochar has higher adsorption capacities than the fresh one. Moreover, a fast adsorption rate for DBP was observed, which can be attributed to the smaller size and shorter carbon chains in the DBP molecule, resulting in faster diffusion into the biochar pores. In the binary PAEs component systems, competition between DEHP and DBP in their adsorption to the biochars was observed, and DEHP (11.7-15.0 mg g) was preferred over DBP (3.4-7.9 mg g). The stronger adsorption of DEHP can be explained by stronger hydrophobic interaction with biochar. Compared to DBP, DEHP has a high octanol-water partition coefficient (logK) and low water solubility. The positive entropy (ΔS) and enthalpy(ΔH) values for the adsorption of both DEHP and DBP further indicated that hydrophobic interaction played an important role, even though H-bonds and π-π interactions could also be involved.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130639DOI Listing
April 2021

A proteomic analysis of urine biomarkers in autism spectrum disorder.

J Proteomics 2021 Jun 4;242:104259. Epub 2021 May 4.

Medical School of Chinese PLA, Beijing, China; Department of Laboratory Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing, China. Electronic address:

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by early-onset social-communication challenges, restricted and repetitive behaviors, or unusual sensory-motor behaviors. A lack of specific biomarkers hinders the early diagnosis and treatment of this disease in many children. This study analyzes and validates potential urinary biomarkers using mass spectrometry proteomics. Global proteomics profiles of urine from 19 ASD patients and 19 healthy control subjects were compared to identify significantly changed proteins. These proteins were validated with targeted proteomics using parallel reaction monitoring (PRM) in an independent validation set consisting of samples from 40 ASD patients and 38 healthy controls. A total of 34 significantly changed proteins were found in the discovery set, among which seven proteins were identified as potential biomarkers for ASD through PRM assays in the validation set. Of these seven proteins, immunoglobulin kappa variable 4-1, immunoglobulin kappa variable 3-20, and immunoglobulin lambda variable 1-51 were up-regulated, while ATP synthase F1 subunit alpha, 10 kDa heat shock protein, apolipoprotein C-III, and arylsulfatase F were down-regulated. Six of these seven proteins support previous findings that ASD is accompanied by altered immune response and lipid metabolism, as well as mitochondrial dysfunction. This study lays the groundwork for additional research using biomarkers to clinically diagnose ASD. The proteomics and PRM raw data of this study have been deposited under the accession number IPX0002592000 at iProX. SIGNIFICANCE: This study identified 34 proteins in urine of ASD patients that were significantly changed from the urinary proteins of healthy subjects using LC-MS/MS-based proteomics in a discovery set. Seven of these proteins were validated by PRM analysis in an independent validation set. This report represents the first description of combined label-free quantitative proteomics and PRM analysis of targeted proteins for discovery of ASD urinary biomarkers. The results will be helpful for early diagnosis and can provide additional insight into the molecular mechanisms of ASD.
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http://dx.doi.org/10.1016/j.jprot.2021.104259DOI Listing
June 2021

Constructing Densely Compacted Graphite/Si/SiO Ternary Composite Anodes for High-Performance Li-Ion Batteries.

ACS Appl Mater Interfaces 2021 May 6;13(19):22323-22331. Epub 2021 May 6.

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Graphite has dominated the market of anode materials for lithium-ion batteries in applications such as consumer electronic devices and electric vehicles. As commercial graphite anodes are approaching their theoretical capacity, significant efforts have been dedicated towards higher capacity by blending capacity-enhancing additives (e.g., Si) with graphite particles. In spite of the improved gravimetric capacity, the areal capacity of such composite anodes might decrease due to excess void spaces and an incompatible material size distribution. Herein, a rational design of compact graphite/Si/SiO ternary composites has been proposed to address the abovementioned issues. Si/SiO clusters with an optimal particle size are homogeneously dispersed in the interstitial spaces between graphite particles to promote the packing density, leading to a higher areal capacity than that of pure graphite with equivalent mass loading or electrode thickness. By taking the full intrinsic advantages of graphite, Si, and SiO, the composite electrodes exhibit 553.6 mAh g after 700 cycles with a capacity retention of 95.2%. Furthermore, the graphite/Si/SiO electrodes demonstrate a high coulombic efficiency with an average of 99.68% from 2nd to 200th cycles and areal capacities above 1.75 mAh cm during 200 cycles with an areal mass loading as high as 4.04 mg cm. A packing model has been proposed and verified by experimental investigation as a design principle of densely compacted anodes. The effective strategy of introducing Si/SiO clusters into the void spaces between graphite particles provides an alternative solution for implementation of graphite-Si composite anodes in next-generation Li-ion cells.
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http://dx.doi.org/10.1021/acsami.1c01877DOI Listing
May 2021

Author Correction: Centrifugation does not remove bacteria from the fat fraction of human milk.

Sci Rep 2021 May 5;11(1):9957. Epub 2021 May 5.

School of Molecular Sciences, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1038/s41598-021-88094-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100291PMC
May 2021

Gene expression profiles for an immunoscore model in bone and soft tissue sarcoma.

Aging (Albany NY) 2021 05 4;13(10):13708-13725. Epub 2021 May 4.

Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Background: Immune infiltration is a prognostic marker to clinical outcomes in various solid tumors. However, reports that focus on bone and soft tissue sarcoma are rare. The study aimed to analyze and identify how immune components influence prognosis and develop a novel prognostic system for sarcomas.

Methods: We retrieved the gene expression data from 3 online databases (GEO, TCGA, and TARGET). The immune fraction was estimated using the CIBERSORT algorithm. After that, we re-clustered samples by K-means and constructed immunoscore by the least absolute shrinkage and selection operator (LASSO) Cox regression model. Next, to confirm the prognostic value, nomograms were constructed.

Results: 334 samples diagnosed with 8 tumor types (including osteosarcoma) were involved in our analysis. Patients were next re-clustered into three subgroups (OS, SAR1, and SAR2) through immune composition. Survival analysis showed a significant difference between the two soft tissue groups: patients with a higher proportion of CD8+ T cells, macrophages M1, and mast cells had favorable outcomes (p=0.0018). Immunoscore models were successfully established in OS and SAR2 groups consisting of 12 and 9 cell fractions, respectively. We found immunosocre was an independent factor for overall survival time. Patients with higher immunoscore had poor prognosis (p<0.0001). Patients with metastatic lesions scored higher than those counterparts with localized tumors (p<0.05).

Conclusions: Immune fractions could be a useful tool for the classification and prognosis of bone and soft tissue sarcoma patients. This proposed immunoscore showed a promising impact on survival prediction.
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http://dx.doi.org/10.18632/aging.202956DOI Listing
May 2021

Effect of calcium and iron-enriched biochar on arsenic and cadmium accumulation from soil to rice paddy tissues.

Sci Total Environ 2021 Sep 17;785:147163. Epub 2021 Apr 17.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, PR China; College of Resource and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou, Jiangxi 341000, PR China.

Arsenic (As) and cadmium (Cd) are nonessential toxic metal(loids) that are carcinogenic to humans. Hence, reducing the bioavailability of these metal(loids) in soils and decreasing their accumulation in rice grains is essential for agroecology, food safety, and human health. Iron (Fe)-enriched corncob biochar (FCB), Fe-enriched charred eggshell (FEB), and Fe-enriched corncob-eggshell biochar (FCEB) were prepared for soil amelioration. The amendment materials were applied at 1% and 2% application rates to observe their alleviation effects on As and Cd loads in rice paddy tissues and yield improvements using pot trials. The FCEB treatment increased paddy yields compared to those of FCB (9-12%) and FEB (3-36%); this could be because it contains more plant essential nutrients than FCB and a lower calcite content than that of FEB. In addition, FCEB significantly reduced brown rice As (As, 29-60%) and Cd (Cd, 57-81%) contents compared to those of the untreated control (CON). At a 2% application rate, FCEB reduced the average mobility of As (56%) and Cd (62%) in rhizosphere porewater and enhanced root Fe-plaque formation (76%) compared to those of CON. Moreover, the enhanced Fe-plaque sequestered a substantial amount of As (171.4%) and Cd (90.8%) in the 2% FCEB amendment compared to that of CON. Pearson correlation coefficients and regression analysis indicated that two key mechanisms likely control As and Cd accumulations. First, rhizosphere soil pH and Eh controlled As and Cd availabilities in porewaters and their speciation in the soil. Second, greater Fe-plaque formation in paddy roots grown in the amended soils provided a barrier for plant uptake of the metal(loids). These observations demonstrate that soil amendment with Fe-enriched corncob-eggshell biochar (e.g., 2% FCEB) is a prospective approach for the remediation of metal accumulation from the soil to grain system while simultaneously increasing paddy yield.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147163DOI Listing
September 2021

Gut Microbiota and Diarrhea: An Updated Review.

Front Cell Infect Microbiol 2021 15;11:625210. Epub 2021 Apr 15.

Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.
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http://dx.doi.org/10.3389/fcimb.2021.625210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082445PMC
April 2021

Contextual Cueing Accelerated and Enhanced by Monetary Reward: Evidence From Event-Related Brain Potentials.

Front Hum Neurosci 2021 15;15:623931. Epub 2021 Apr 15.

Key Research Base of Humanities and Social Sciences of the Ministry of Education, Academy of Psychology and Behavior, Tianjin Normal University, Tianjin, China.

The vital role of reward in guiding visual attention has been supported by previous literatures. Here, we examined the motivational impact of monetary reward feedback stimuli on visual attention selection using an event-related potential (ERP) component called stimulus-preceding negativity (SPN) and a standard contextual cueing (CC) paradigm. It has been proposed that SPN reflects affective and motivational processing. We focused on whether incidentally learned context knowledge could be affected by reward. Both behavior and brain data demonstrated that contexts followed by reward feedback not only gave rise to faster implicit learning but also obtained a larger CC effect.
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http://dx.doi.org/10.3389/fnhum.2021.623931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081838PMC
April 2021

Na(VO)(PO)F nanocuboids/graphene hybrid materials as faradic electrode for extra-high desalination capacity.

J Colloid Interface Sci 2021 Sep 20;598:511-518. Epub 2021 Apr 20.

Research Center for Environmental Functional Materials, College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China.

Capacitive deionization (CDI) is considered as a promising desalination technology due to its low energy consumption and no two-second pollution. But the development of traditional CDI is limited by its two drawbacks, which are low deionization capacity and unavoidable parasitic reactions. Hybrid capacitive deionization (HCDI), which is composed of a faradic electrode and an electrical-double-layer electrode, effectively solves the above problem. Herein, we report a typical NASICON material Na(VO)(PO)F and modify it with rGO, then apply it in HCDI firstly and receive a superior desalination performance. Five samples are prepared by adding different contents GO solution and we choose the best one (NVOPF-4) with the lowest resistance for the desalination tests according to electrochemical performance. The result of desalination shows a high desalination capacity of 175.94 mg·g, low energy consumption of 0.35 kWh·kg-NaCl, and the energy recovery is 20% at a current density of 25 mg·g. [email protected] displays a promising ability for desalination in capacitive deionization, further confirming NASICON be a suitable material type for HCDI electrode materials.
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http://dx.doi.org/10.1016/j.jcis.2021.04.051DOI Listing
September 2021

Bioactive monoterpene phenol dimers from the fruits of Psoralea corylifolia L.

Bioorg Chem 2021 Jul 20;112:104924. Epub 2021 Apr 20.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address:

Nine undescribed monoterpene phenol dimers, bisbakuchiols D-L (1-9), were isolated from the fruits of Psoralea corylifolia L. Their structures were elucidated based on extensive spectral analysis. The absolute configurations of 1-9 were specified by experimental and quantum chemical calculations of ECD spectra, and that of 1 was further established by X-ray diffraction analysis using Cu Kα radiation. Bisbakuchiols (1-4) were composed of two bakuchiols, one of which was cyclized via a C-7'/ C-12' single bond to form a six-member ring, and connect to each other by C-4-O-C-13' bonds. Bisbakuchiols (7-9) had a pyran ring by linkage of C-8-O-C-12. In the enzyme assay, compounds 5 and 9 exhibited significant PTP1B inhibitory activities with IC values of 0.69 and 0.73 μM, and compounds 1 and 3 showed moderate PTP1B inhibitory activities. Furthermore, a molecular docking simulation of PTP1B and active compounds 5 and 9 showed that these active compounds possess low binding affinities ranging from -6.9 to -7.1 kcal/mol.
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http://dx.doi.org/10.1016/j.bioorg.2021.104924DOI Listing
July 2021

Elevated Interleukin-18 Receptor Accessory Protein Mediates Enhancement in Reactive Oxygen Species Production in Neutrophils of Systemic Lupus Erythematosus Patients.

Cells 2021 Apr 21;10(5). Epub 2021 Apr 21.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Interleukin-18 receptor accessory protein (IL18RAP) is an indispensable subunit for the IL-18 receptor (IL-18R) complex's ability to mediate high-affinity IL-18 binding and signalling transduction. Interest in IL-18 in systemic lupus erythematosus (SLE) has been mostly focused on its role as a type 1 T helper cell-driving cytokine. The functional significance of IL18RAP in mediating the IL-18-driven response in myeloid cells in SLE remains largely unexplored. This study aimed to investigate the expression and function significance of IL18RAP in neutrophils of SLE patients. By qRT-PCR and Western blot analyses, elevated expressions of IL18RAP mRNA and protein were observed in neutrophils from SLE patients-particularly those with a history of nephritis. IL18RAP expression correlated negatively with complement 3 level and positively with disease activity, with higher expression in patients exhibiting renal and immunological manifestations. The increased IL18RAP expression in SLE neutrophils could be attributed to elevated type I interferon level in sera. Functionally, neutrophils from SLE patients showed higher IL-18-mediated enhancement in reactive oxygen species (ROS) generation, which showed positive correlation with IL18RAP expression and could be neutralized by anti-IL18RAP blocking antibodies. Taken together, our findings suggest that IL-18 could contribute to SLE pathogenesis through mediation of neutrophil dysfunction via the upregulation of IL18RAP expression.
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http://dx.doi.org/10.3390/cells10050964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143138PMC
April 2021