Publications by authors named "Jie Gu"

360 Publications

Comprehensive Genome-Scale Analysis of Esophageal Carcinoma With Esophageal Tissue-Resident Micro-Environment Discrepancy.

Front Microbiol 2022 2;13:859352. Epub 2022 May 2.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

To figure out the molecular mechanism in the esophageal squamous carcinoma (ESCC) with the discrepancy in the tissue-resident microbiota, we selected clinical features, RNA sequences, and transcriptomes of ESCC patients from The Cancer Genome Atlas (TCGA) website and detailed tissue-resident microbiota information from The Cancer Microbiome Atlas ( = 60) and explored the infiltration condition of particular microbiota in each sample. We classified the tissue-resident micro-environment of ESCC into two clusters (A and B) and built a predictive classifier model. Cluster A has a higher proportion of certain tissue-resident microbiota with comparatively better survival, while Cluster B has a lower proportion of certain tissue-resident microbiota with comparatively worse survival. We showed traits of gene and clinicopathology in the esophageal tissue-resident micro-environment (ETM) phenotypes. By comparing the two clusters' molecular signatures, we find that the two clusters have obvious differences in gene expression and mutation, which lead to pathway expression discrepancy. Several pathways are closely related to tumorigenesis. Our results may demonstrate a synthesis of the infiltration pattern of the esophageal tissue-resident micro-environment in ESCC. We reveal the mechanism of esophageal tissue-resident microbiota discrepancy in ESCC, which may contribute to therapy progress for patients with ESCC.
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http://dx.doi.org/10.3389/fmicb.2022.859352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108775PMC
May 2022

Long-term exposure of zebrafish to bisphenol F: Adverse effects on parental reproduction and offspring neurodevelopment.

Aquat Toxicol 2022 May 9;248:106190. Epub 2022 May 9.

Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing 210042, China. Electronic address:

Bisphenol F (BPF), an alternative to bisphenol A (BPA) has potential endocrine and reproductive toxicity; however, the effects of environmental concentrations of BPF on the reproductive and developmental toxicity of offspring following parental exposure to BPF remain unclear. In the present study, the effects of life-cycle BPF exposure at environmental concentrations on zebrafish reproduction, offspring growth, and development were investigated. The results showed that the life-cycle of BPF exposure significantly elevated oxidative stress levels, increased gonadal apoptosis, and reduced zebrafish (F0) spawning. Notably, through maternal transfer, BPF exposure significantly affected offspring development. Developmental parameters such as hatching rate, spontaneous movements, heart rate, body length, and locomotor behavior decreased in zebrafish larvae (F1). In addition, the expression levels of genes related to oxidative stress, apoptosis, and neurodevelopment were altered in F1 larvae. Therefore, the present study provides evidence that BPF, even at environmental concentrations, can be potentially adverse in terms of reproductive defects and offspring neurodevelopmental disorders. Therefore, BPF, as a substitute for BPA, is worthy of in-depth evaluation.
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http://dx.doi.org/10.1016/j.aquatox.2022.106190DOI Listing
May 2022

Repetitive transcranial magnetic stimulation (rTMS) for multiple neurological conditions in rodent animal models: A systematic review.

Neurochem Int 2022 May 2;157:105356. Epub 2022 May 2.

Department of Anatomy and Neurobiology of Xuzhou Medical University, Xuzhou, Jiangsu province, 221004, China. Electronic address:

Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique. Recently, rTMS has shown promising therapeutic potential in multiple neurological conditions. Nevertheless, challenges remain in the clinical application of rTMS, which mainly due to the lack of consensus on optimal stimulation protocols and poor understanding of the exact targets driving its action. Experimental animal research with more controllable factors may contribute to fill our knowledge gap in this area, and to accelerate the development of clinical translation studies. Therefore, the current study was designed to systematically review the effects of rTMS on animal models of certain diseases and evaluate its potential mechanisms of action, which may guide future studies aiming to improve the therapeutic utilization for these diseases.

Methods: A systematic literature search was conducted through the PubMed online database on August 19, 2021. The search strategy consisted of two main components: rTMS and stroke, Alzheimer's disease (AD), vascular dementia (VaD), and Parkinson's disease (PD), with results limited to animal studies.

Results: We identified 41 animal studies, 21 that examined stroke, 8 that investigated Alzheimer's disease, 5 that studied vascular dementia, and 7 that examined Parkinson's disease, all of these studies were conducted in rodents (rat and mice). Despite variations in study design and research methods, the therapeutic benefits of rTMS, as reflected in the alleviation of disease-related symptoms and pathological improvements, have been reported in these studies. rTMS induces multi-directional changes at the cellular and molecular levels, including a significant contribution to synaptic plasticity. Furthermore, the curative effects of rTMS are related to stimulation parameters, with high-frequency rTMS reported has better therapeutic efficacy in several studies. In terms of safety, one study involving combination therapy reported the adverse effects of rTMS administration.

Conclusions: rTMS have shown encouraging therapeutic value in rodent models of stroke, AD, VaD, and PD. Nonetheless, the optimal protocols and exact target of action for this therapy remain to be determined. Correspondingly, further research is still needed to bridge the translation gap between rodent experiments and clinical application, which might lead to new directions in the treatment of multiple neurological disorders.
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http://dx.doi.org/10.1016/j.neuint.2022.105356DOI Listing
May 2022

Effects and microbial mechanisms of phosphogypsum and medical stone on organic matter degradation and methane emissions during swine manure composting.

J Environ Manage 2022 May 2;315:115139. Epub 2022 May 2.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China.

The degradation of organic matter (OM) and CH emissions during composting greatly influence the composting efficiency and greenhouse effect. This study evaluated the effects of adding phosphogypsum (PPG) and medical stone (MS) on OM breakdown, CH emissions, and their underlying mechanisms. MS accelerated the breakdown of OM in the early composting stage, whereas PPG increased it in the cooling and maturation periods. At the ending of composting, humification was also significantly promoted by PPG and MS (P < 0.05). Moreover, MS and PPG reduced CH emissions by 27.64% and 23.12%, respectively, and significantly inhibited the activities of methanogens in terms of their abundance (mcrA) and composition (dominant genera such as Methanobrevibacter, Methanocorpusculum, and Methanothermus) (P < 0.05). Interestingly, MS enhanced the activity of enzymes and bacterial metabolism related to OM degradation in the early composting stage, whereas PPG promoted them during the cooling and maturity stages. MS and PPG inhibited the activities of enzymes related to CH release during the cooling and maturity stages. Therefore, PPG and MS may have influenced OM degradation and CH releases during composting via changes in bacterial metabolism and enzyme activity levels. PPG and MS could have altered the activities of methanogens to influence the transformation of carbon and CH emissions according to network analysis and partial least-squares path modeling analysis. These findings provide insights at the molecular level into the effects of adding PPG and MS on OM degradation and CH emissions during composting, thereby facilitating the application of PPG and MS in composting systems.
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http://dx.doi.org/10.1016/j.jenvman.2022.115139DOI Listing
May 2022

Quantifiable models for surface protonic conductivity in porous oxides - case of monoclinic ZrO.

Phys Chem Chem Phys 2022 May 18;24(19):11856-11871. Epub 2022 May 18.

Department of Chemistry, University of Oslo, Centre for Materials Science and Nanotechnology (SMN), FERMiO, Gaustadalléen 21, NO-0349 Oslo, Norway.

The surface protonic conductivity of porous monoclinic ZrO sintered at temperatures in the range 700-1100 °C yielding relative densities of around 60% and grain sizes of approximately 160 nm has been studied using impedance spectroscopy as a function of temperature well below the sintering temperature in wet atmospheres ( = 0.03 bar). The sum of two high-frequency impedance responses is argued to represent surface conductance according to a new model of impedance over curved surfaces. A simple brick layer model is applied to compare the measured macroscopic conductivities with predicted surface conductances. The well-faceted samples sintered at the highest temperatures exhibited activation enthalpies up to 58 kJ mol of surface protonic conduction in wet atmospheres at temperatures above 300 °C. We attribute this to the mobility of dissociated protons over surface oxide ions, and the high preexponential is in good agreement with a model comprising relatively strong dissociative chemisorption. With decreasing sintering temperature, the particles appear more rounded, with less developed facets, and we obtain activation enthalpies of surface protonic conduction in the chemisorbed layer down to around 30 kJ mol, with correspondingly smaller preexponentials and an observed dependency. Supported by the thermogravimetry of adsorption, we attribute this to weaker and more molecular chemisorption on the more randomly terminated less faceted surfaces, providing water layers with fewer dissociated charge carrying protons, but also smaller activation enthalpies of mobility. Below 200 °C, all samples exhibit a strongly inverse temperature dependency characteristic of conduction in the 1st physisorbed layer with increasing coverage. The preexponentials correspond well to the models of physisorption, with dissociation to and proton migration between physisorbed water molecules. The enthalpies fit well to physisorption and with enthalpies of dissociation and proton mobility close to those of liquid water. We have by this introduced models for proton conduction in chemisorbed and physisorbed water on ZrO, applicable to other oxides as well, and shown that preexponentials are quantitatively assessable in the order-of-magnitude level to discriminate models a simple brick layer model based topographical analysis of the ceramic microstructure.
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http://dx.doi.org/10.1039/d1cp05668aDOI Listing
May 2022

Dynamics and key drivers of antibiotic resistance genes during aerobic composting amended with plant-derived and animal manure-derived biochars.

Bioresour Technol 2022 Apr 27;355:127236. Epub 2022 Apr 27.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.

Plant-derived and animal manure-derived biochars have been used to improve the quality of compost but the differences in their effects on antibiotic resistance genes (ARGs) during composting are unclear. This study selected two types of biochar (RB and PB) produced from abundant agricultural waste to be added to the compost. Adding plant-derived RB performed better in ARGs, mobile genetic elements, and human pathogenic bacteria removal during aerobic composting, whereas adding manure-derived PB even increased ARGs abundance. Vertical gene transfer was possibly the key mechanism for persistent ARGs, and easily removed ARGs were regulated by horizontal and vertical gene transfer. Adding plant-derived RB reduced the abundances of persistent ARG hosts (e.g., Pseudomonas and Longispora) and ARG-related metabolic pathways and genes. The higher nitrogen content of manure-derived PB may have promoted the proliferation of ARG hosts. Overall, adding manure-derived biochar during composting may not be the optimal option for eliminating ARGs.
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http://dx.doi.org/10.1016/j.biortech.2022.127236DOI Listing
April 2022

Automated machine learning for secure key rate in discrete-modulated continuous-variable quantum key distribution.

Opt Express 2022 Apr;30(9):15024-15036

Continuous-variable quantum key distribution (CV QKD) with discrete modulation has attracted increasing attention due to its experimental simplicity, lower-cost implementation and compatibility with classical optical communication. Correspondingly, some novel numerical methods have been proposed to analyze the security of these protocols against collective attacks, which promotes key rates over one hundred kilometers of fiber distance. However, numerical methods are limited by their calculation time and resource consumption, for which they cannot play more roles on mobile platforms in quantum networks. To improve this issue, a neural network model predicting key rates in nearly real time has been proposed previously. Here, we go further and show a neural network model combined with Bayesian optimization. This model automatically designs the best architecture of neural network computing key rates in real time. We demonstrate our model with two variants of CV QKD protocols with quaternary modulation. The results show high reliability with secure probability as high as 99.15% - 99.59%, considerable tightness and high efficiency with speedup of approximately 10 in both cases. This inspiring model enables the real-time computation of unstructured quantum key distribution protocols' key rate more automatically and efficiently, which has met the growing needs of implementing QKD protocols on moving platforms.
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http://dx.doi.org/10.1364/OE.455762DOI Listing
April 2022

Evaluation of CTB-sLip for Targeting Lung Metastasis of Colorectal Cancer.

Pharmaceutics 2022 Apr 15;14(4). Epub 2022 Apr 15.

Center of Medical Research and Innovation, Shanghai Pudong Hospital & Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 201399, China.

Lung metastasis of colorectal cancer is common in the clinic; however, precise targeting for the diagnosis and therapy purposes of those lung metastases remains challenging. Herein, cholera toxin subunit b (CTB) protein was chemically conjugated on the surface of PEGylated liposomes (CTB-sLip). Both human-derived colorectal cancer cell lines, HCT116 and HT-29, demonstrated high binding affinity and cellular uptake with CTB-sLip. In vivo, CTB-sLip exhibited elevated targeting capability to the lung metastasis of colorectal cancer in the model nude mice in comparison to PEGylated liposomes (sLip) without CTB modification. CTB conjugation induced ignorable effects on the interaction between liposomes and plasma proteins but significantly enhanced the uptake of liposomes by numerous blood cells and splenic cells, leading to relatively rapid blood clearance in BALB/c mice. Even though repeated injections of CTB-sLip induced the production of anti-CTB antibodies, our results suggested CTB-sLip as promising nanocarriers for the diagnosis of lung metastasis of colorectal cancer.
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http://dx.doi.org/10.3390/pharmaceutics14040868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032673PMC
April 2022

Strong and Reversible Covalent Double Network Hydrogel Based on Force-Coupled Enzymatic Reactions.

Angew Chem Int Ed Engl 2022 Apr 14:e202201765. Epub 2022 Apr 14.

Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University, Nanjing, 210093, China.

Biological load-bearing tissues are strong, tough, and recoverable under periodic mechanical loads. However, such features have rarely been achieved simultaneously in the same synthetic hydrogels. Here, we use a force-coupled enzymatic reaction to tune a strong covalent peptide linkage to a reversible bond. Based on this concept we engineered double network hydrogels that combine high mechanical strength and reversible mechanical recovery in the same hydrogels. Specifically, we found that a peptide ligase, sortase A, can promote the proteolysis of peptides under force. The peptide bond can be re-ligated by the same enzyme in the absence of force. This allows the sacrificial network in the double-network hydrogels to be ruptured and rebuilt reversibly. Our results demonstrate a general approach for precisely controlling the mechanical and dynamic properties of hydrogels at the molecular level.
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http://dx.doi.org/10.1002/anie.202201765DOI Listing
April 2022

Structural Characterization and In Vitro Antioxidant Activity of Metallothionein from .

Molecules 2022 Apr 3;27(7). Epub 2022 Apr 3.

College of Food and Pharmaceutical Sciences, Ningbo University, Qixing South Road 169, Ningbo 315800, China.

We report here the purification of a novel metal-binding protein from ( MT-1) by gel and ion-exchange chromatography. SDS-PAGE and MALDI-TOF analyses demonstrated that isolated MT-1 was of high purity with a molecular weight of 12.4 kDa. The fluorescence response to SBD-F derivatives revealed that MT-1 contained a large number of sulfhydryl groups, which is a general property of metallothioneins. Zn and Cu metal stoichiometries for MT-1 were 3.97:1 and 0.55:1, respectively. The proportion of cysteine (Cys) residues in the amino acid composition was 32.69%, and aromatic amino acids were absent. The peptide sequence coverage with calmodulin (accession AOA3S8FSK5) was 60%. Infrared spectroscopy of MT-1 revealed two obvious peaks at absorption frequencies for the amide I band and the amide II band. CD spectra revealed that the secondary structure was mainly composed of random coil (57.6%) and β-sheet (39.9%). An evaluation of in vitro antioxidant activity revealed that isolated MT-1 has strong reducing activities, exhibiting scavenging rates for DPPH and OH of 77.8% and 75.8%, respectively (IC values 0.57 mg/mL and 1.1 mg/mL). MT-1 may be used as a functional additive in cosmetics, health foods, and medical products, as well as a reference material for quantitative analysis of metallothionein in such products.
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http://dx.doi.org/10.3390/molecules27072320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000697PMC
April 2022

Clarifying the beneficial effects of plant growth-promoting rhizobacteria for reducing abundances of antibiotic resistance genes during swine manure composting.

Bioresour Technol 2022 Jun 5;353:127117. Epub 2022 Apr 5.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.

This study investigated the effects on antibiotic resistance genes (ARGs) and the related mechanisms of different plant growth-promoting rhizobacteria (PGPR) inoculation strategies during composting: no inoculation (CK), inoculation in initial phase (T1), inoculation in cooling phase (T2), and inoculation in both initial and cooling phases (T3). After composting, the total relative abundances (RAs) of ARGs decreased by 0.26 and 0.03 logs under T3 and T2, respectively, but increased by 0.05 and 0.22 logs under T1 and CK. The abundances of eight ARGs were lowest under T3, including some high risk ARGs with clinical importance. Bioavailable Cu significantly affected the readily removed ARGs, and PGPR inoculation decreased the bioavailability of Cu. T3 reduced the abundances of potential pathogen hosts, inhibited horizontal gene transfer by reducing the RAs of mobile gene elements (0.48 logs), and downregulated the expression of genes related to ARG propagation, thereby decreasing the ecological risk of ARGs.
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http://dx.doi.org/10.1016/j.biortech.2022.127117DOI Listing
June 2022

LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.

J Cell Mol Med 2022 May 3;26(10):2895-2907. Epub 2022 Apr 3.

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Pyroptosis is associated with various cardiovascular diseases. Increasing evidence suggests that long noncoding RNAs (lncRNAs) have been implicated in gene regulation, but how lncRNAs participate in the regulation of pyroptosis in the heart remains largely unknown. In this study, we aimed to explore the antipyroptotic effects of lncRNA FGF9-associated factor (FAF) in acute myocardial infarction (AMI). The expression patterns of lncRNA FAF, miR-185-5p and P21 activated kinase 2 (PAK2) were detected in hypoxia/ischaemia-induced cardiomyocytes. Hoechst 33342/PI staining, lactate dehydrogenase (LDH) release assay, immunofluorescence and Western blotting were conducted to assay cell pyroptosis. The interaction between lncRNA FAF, miR-185-5p and PAK2 was verified by bioinformatics analysis, small RNA sequencing luciferase reporter assay and qRT-PCR. The expression of LncRNA FAF was downregulated in hypoxic cardiomyocytes and myocardial tissues. Overexpression of lncRNA FAF could attenuate cardiomyocyte pyroptosis, improve cell viability and reduce infarct size during the procession of AMI. Moreover, lncRNA FAF was confirmed as a sponge of miR-185-5p and promoted PAK2 expression in cardiomyocytes. Collectively, our findings reveal a novel lncRNA FAF/miR-185-5p/PAK2 axis as a crucial regulator in cardiomyocyte pyroptosis, which might be a potential therapeutic target of AMI.
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http://dx.doi.org/10.1111/jcmm.17304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097851PMC
May 2022

Nomogram for predicting risk factor of urosepsis in patients with diabetes after percutaneous nephrolithotomy.

BMC Anesthesiol 2022 03 31;22(1):87. Epub 2022 Mar 31.

Urology and Lithotripsy Center, Peking University People's Hospital, 133 Fuchengmen Inner Street, Xicheng District, Beijing, 100034, People's Republic of China.

Background: Urosepsis is an infectious complication after percutaneous nephrolithotomy (PCNL). This study aimed to analyze the perioperative factors related to urosepsis after PCNL for upper urinary calculi and establish a nomogram to predict the probability of postoperative urosepsis based on the risk factors.

Methods: The Clinical data of one-stage PCNL for upper urinary stones in patients already diagnosed with type 2 diabetes between June 2010 and June 2020 were retrospectively analyzed. The patients were divided into two groups according to whether urosepsis occurred after surgery, and univariate and multivariate logistic regression analyses evaluated the risk factors for urosepsis. Moreover, the corresponding nomogram prediction model was determined by the regression coefficient.

Results: All 366 patients with diabetes underwent one-stage PCNL. Seventy-one (19.4%) patients had urosepsis after surgery, and their hospitalization time was longer than that of patients without urosepsis. Moreover, the incidence of non-infection-related complications was higher. Multivariate logistic regression analysis revealed four independent risk factors associated with postoperative urosepsis, including positive urine nitrite (odds ratio [OR] = 3.326, P = 0.007), positive urine culture (OR = 2.213, P = 0.023), intraoperative hypotension (OR = 8.968, P < 0.001), and staghorn calculi (OR = 3.180, P = 0.002). The above independent risk factors were used as variables to construct the nomogram. The nomogram model was internally validated. The calculated concordance index was 0.824. The Hosmer-Lemeshow goodness-of-fit test was performed (P = 0.972 > 0.05). The area under the curve of this model was 0.831, indicating that the nomogram model had good accuracy in predicting the probability of urosepsis in patients who underwent PCNL with diabetes and had good consistency with the actual risk.

Conclusion: Positive urine culture, positive urine nitrite, staghorn calculi, and intraoperative hypotension were independent risk factors for urosepsis in patients who underwent one-stage PCNL with diabetes. The new nomogram could accurately assess the risk of urosepsis after PCNL in patients with diabetes.
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http://dx.doi.org/10.1186/s12871-022-01629-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969277PMC
March 2022

Tuning Strain Stiffening of Protein Hydrogels by Charge Modification.

Int J Mol Sci 2022 Mar 11;23(6). Epub 2022 Mar 11.

Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University, Nanjing 210093, China.

Strain-stiffening properties derived from biological tissue have been widely observed in biological hydrogels and are essential in mimicking natural tissues. Although strain-stiffening has been studied in various protein-based hydrogels, effective approaches for tuning the strain-stiffening properties of protein hydrogels have rarely been explored. Here, we demonstrated a new method to tune the strain-stiffening amplitudes of protein hydrogels. By adjusting the surface charge of proteins inside the hydrogel using negatively/positively charged molecules, the strain-stiffening amplitudes could be quantitively regulated. The strain-stiffening of the protein hydrogels could even be enhanced 5-fold under high deformations, while the bulk property, recovery ability and biocompatibility remained almost unchanged. The tuning of strain-stiffening amplitudes using different molecules or in different protein hydrogels was further proved to be feasible. We anticipate that surface charge adjustment of proteins in hydrogels represents a general principle to tune the strain-stiffening property and can find wide applications in regulating the mechanical behaviors of protein-based hydrogels.
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http://dx.doi.org/10.3390/ijms23063032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950043PMC
March 2022

Robust SiO-AlO/Agarose Composite Aerogel Beads with Outstanding Thermal Insulation Based on Coal Gangue.

Gels 2022 Mar 6;8(3). Epub 2022 Mar 6.

School of Chemistry and Chemical Engineering, Inner Mongolia University of Science & Technology, Baotou 014010, China.

Advanced SiO-AlO aerogel materials have outstanding potential in the field of thermal insulation. Nevertheless, the creation of a mechanically robust and low-cost SiO-AlO aerogel material remains a considerable challenge. In this study, SiO-AlO aerogel based on coal gangue, which is a type of zero-cost inorganic waste, was constructed in porous agarose aerogel beads, followed by simple chemical vapor deposition of trimethylchlorosilane to fabricate SiO-AlO/agarose composite aerogel beads (SCABs). The resulting SCABs exhibited a unique nanoscale interpenetrating network structure, which is lightweight and has high specific surface area (538.3 m/g), hydrophobicity (approximately 128°), and excellent thermal stability and thermal insulation performance. Moreover, the compressive strength of the SCABs was dramatically increased by approximately a factor of ten compared to that of native SiO-AlO aerogel beads. The prepared SCABs not only pave the way for the design of a novel aerogel material for use in thermal insulation without requiring expensive raw materials, but also provide an effective way to comprehensively use coal gangue.
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http://dx.doi.org/10.3390/gels8030165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952686PMC
March 2022

Risk of horizontal transfer of intracellular, extracellular, and bacteriophage antibiotic resistance genes during anaerobic digestion of cow manure.

Bioresour Technol 2022 May 15;351:127007. Epub 2022 Mar 15.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.

The fate of intracellular antibiotic resistance genes (iARGs), extracellular ARGs (eARGs) and bacteriophage ARGs (bARGs) during anaerobic digestion (AD) of cow manure is unclear. Thus, the characteristics of iARGs, eARGs and bARGs during mesophilic AD (MAD) and thermophilic AD (TAD) of cow manure were investigated. The absolute abundances of iARGs decreased by 69.82% after TAD. After MAD and TAD, the total absolute abundances of eARGs increased by 63.5 times and 67.6 times, respectively, whereas those of the bARGs increased by 47.60% and 59.22%. eARGs were mainly derived from the non-specific lysis of Firmicutes, Bacteroidetes, while bacteriophages had a wide range of hosts. The variations in iARGs, eARGs and bARGs were affected by the microbial hosts but also directly driven by physicochemical factors (e.g., pH). Overall, the findings of this study revealed that there may be a risk of eARGs and bARGs disseminating during the AD of cow manure.
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http://dx.doi.org/10.1016/j.biortech.2022.127007DOI Listing
May 2022

Exposure of preschool-aged children to highly-concerned bisphenol analogues in Nanjing, East China.

Ecotoxicol Environ Saf 2022 Mar 11;234:113397. Epub 2022 Mar 11.

Nanjing Institute of Environmental Science, Ministry of Ecology and Environment, Nanjing, Jiangsu 210042, PR China. Electronic address:

Bisphenol analogues (BPs) have already attracted wide concern owing to the environmental and health risks they pose. The exposure pathways and health risk of preschool-aged children to BPs, however, are still poorly understood. In this study, we choose population survey with 184 preschool-age children from a suburb of Nanjing, eastern China, further reveal the internal and external exposures concentrations, distribution profiles, potential sources and eventually assess health risk of preschool-age children to eight kinds of BPs. The results verify that the 95th percentile (P95) concentrations of ƩBPs ranged from 0.27 to 41.6 ng/mL, with a median concentration of 7.83 ng/mL in the urine samples. BPA, and BPF were the predominant BPs in urine, accounting for 67.3%, and 18.0% of ƩBPs. The urine-based estimated daily intake (EDI) of ƩBPs was 187 ng/kg body weight/day. Similarly, BPA, and BPF were the main BPs in the environmental exposure sources, accounting for 80.8%, and 11.7% of the total BPs. Moreover, the total external exposure dose of ƩBPs via the environmental sources was 68.1 ng/kg body weight/day, including BPA (56 ng/kg body weight/day), BPF (7.68 ng/kg body weight/day) and BPB (2.62 ng/kg body weight/day). The oral intake of drinking water and food (vegetables and rice) was the main exposure pathways of BPs in preschool-age children. Furthermore, the hazard quotient (HQ) of BPs have been evaluated and the results show no occurrence of high risk. Additionally, the urine-based EDI was significantly higher than the total external exposure dose, suggesting the existence of other pathways of BP exposure to be further explored. To the best of our knowledge, this is the first study to conduct both an internal and external exposure assessment of BPs.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113397DOI Listing
March 2022

Comparative study of the bacterial distribution and antimicrobial susceptibility of uropathogens in older and younger patients with urinary stones.

BMC Geriatr 2022 03 12;22(1):195. Epub 2022 Mar 12.

Department of Urology, Hunan Provincial People's Hospital, The first affiliated hospital of Hunan normal university, Changsha, 410005, China.

Background: This study compared the bacterial spectrum and antibiotic susceptibility of uropathogens in older and younger patients with urinary stones to provide appropriate antibiotic management.

Methods: We retrospectively reviewed urinary tract infection patients with urolithiasis, presented to Xiangya Hospital from March 2014 to April 2021. Patients were divided into older and younger groups according to 60 years of age. The bacterial spectrum and drug sensitivity of uropathogens were compared.

Results: A total of 542 strains of uropathogens (177 in older and 365 in younger groups) were isolated from 507 patients. E. coli (41.8% vs 43.6%) remains the most common pathogen, followed by E. faecalis (6.2% vs 9.6%) in older and younger groups, respectively. Particularly, K. pneumoniae was significantly more frequent in older (9.6%) than in younger group (4.7%, P < .05). E. faecium was substantially more prevalent in older group (6.2%) than in younger group (2.7%, P < .05). The proportion of males increased in older patients (47.3%) than in younger patients (34.9%, P = 0.007). In both groups, major Gram-negative bacteria (E. coli and K. pneumoniae) revealed a high sensitivity over 70% to piperacillin/tazobactam, imipenem and amikacin, whereas the resistance level was high to penicillin, tetracycline and vancomycin. Major Gram-positive (E. faecalis and E. faecium) isolates demonstrated high sensitivity of over 50% to gentamicin and vancomycin in both groups. Furthermore, uropathogens isolated from younger urolithiasis patients were more susceptible to antimicrobials than those isolated from older patients.

Conclusions: The male increased in the older urolithiasis patients with UTI and uropathogens microbial spectrum in older urolithiasis patients are different from younger. High susceptibility and age should be utilized in empirical antibiotic selection to avoid increased multidrug-resistant bacteria.
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http://dx.doi.org/10.1186/s12877-022-02886-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918295PMC
March 2022

Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer.

Cancer Immunol Immunother 2022 Mar 12. Epub 2022 Mar 12.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: Immune checkpoint blockade (ICB) has been improving patient outcomes of non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual tumor microenvironment. As dominant immune cells in NSCLC, tumor-associated macrophages (TAMs) display high diversity and plasticity. This study aims to find crucial TAM subtypes associated with ICB response in NSCLC.

Materials And Methods: Large cohorts of NSCLC patients from The Cancer Genome Atlas and a single-cell sequencing dataset were integrated to illustrate immunosuppressive phenotypes of TAMs, followed by experimental verification. 341 NSCLC surgical samples and 40 tissue samples of NSCLC patients who received ICB treatment were collected to state the clinical importance of TAMs.

Results: We identified a TREM2 positive () TAM subtype in NSCLC stratifying patient responses to immunotherapy. NSCLC patients with high TREM2 TAM infiltration exhibited advanced tumor progression, inferior prognosis and unique NSCLC molecular characteristics, especially mutations of EGFR. TREM2 TAMs were induced in TME, but not existed in peripheral blood. TREM2 TAMs were enriched with multiple anti-inflammatory cytokines, exhibiting a M2-like immunosuppressive phenotype, and potentiate T cell dysfunction including impaired anti-tumor activity of CD8 T cells and enhanced differentiation towards FOXP3 Tregs, thus facilitating immune evasion of NSCLC. Response rates to PD-1-based ICB were higher in patients with low TREM2 TAMs (31.58%) compared to high TREM2 TAMs (14.29%).

Conclusions: Our findings implicated the immunosuppressive role of TREM2 TAMs in NSCLC, and systematically reveal the clinical significance of TREM2 TAMs as predictive and prognostic markers for NSCLC patients with ICB treatment.
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http://dx.doi.org/10.1007/s00262-022-03173-wDOI Listing
March 2022

The effect of application of a Soton ureteroscope on infection after flexible ureteroscopy lithotripsy.

Wideochir Inne Tech Maloinwazyjne 2022 Mar 13;17(1):232-239. Epub 2021 Jul 13.

Xiangya Hospital Central South University, China.

Introduction: Postoperative infection is still one of the most common complications following flexible ureteroscopy lithotripsy (FURL). However, whether a combination of negative pressure ureteroscopy (and Soton ureteroscopy) is superior to FURL in lithotripsy with regard to intraoperative pressure and possibly the incidence of postoperative infection remains to be validated.

Aim: To explore the effect of a Soton ureteroscope on infection following flexible ureteroscope lithotripsy.

Material And Methods: Sixty patients with kidney stones were randomly divided equally into study and control groups. The operation duration, stone-free rate, postoperative blood routine, procalcitonin, C-reactive protein, and other data between the two groups were then analysed and compared.

Results: There were no statistically significant differences between the study group and the control group regarding the average operation time and the average number of hospitalization days. The mean stone-free rate 1 week after surgery and mean VAS pain score 1 day after surgery for the study group and the control group were 91.3% and 0.27 vs. 76.9% and 0.61, respectively. Notably, the average body temperature after the first day of the operation was 36.4°C in the study group and 36.7°C in the control group. More importantly, concerning postoperative infection index, white blood cells (WBCs), percentage of neutrophils, C-reactive protein, and procalcitonin were all lower in the study group than in the control group.

Conclusions: Compared with flexible ureteroscopy alone, combined use of Soton ureteroscopy is associated with fewer substantially infection following lithotripsy.
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http://dx.doi.org/10.5114/wiitm.2021.107763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886481PMC
March 2022

Shannon Entropy in LS-Coupled Configuration Space for Ni-like Isoelectronic Sequence.

Entropy (Basel) 2022 Feb 12;24(2). Epub 2022 Feb 12.

College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou 730070, China.

The Shannon entropy in an LS-coupled configuration space has been calculated through a transformation from that in a jj-coupled configuration space for a Ni-like isoelectronic sequence. The sudden change of Shannon entropy, information exchange, eigenlevel anticrossing, and strong configuration interaction have been presented for adjacent levels. It is shown that eigenlevel anticrossing is a sufficient and necessary condition for the sudden change of Shannon entropy, and both of them are a sufficient condition for information exchange, which is the same as the case of the jj-coupled configuration space. It is found that the structure of sudden change from jj-coupled into LS-coupled configuration spaces through the LS-jj transformation is invariant for Shannon entropy along the isoelectronic sequence. What is more, in an LS-coupled configuration space, there are a large number of information exchanges between energy levels whether with or without strong configuration interaction, and most of the ground and single excited states of Ni-like ions are more suitable to be described by a jj-coupled or other configuration basis set instead of an LS-coupled configuration basis set according to the configuration mixing coefficients and their Shannon entropy. In this sense, Shannon entropy can also be used to measure the applicability of a configuration basis set or the purity of atomic state functions in different coupling schemes.
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http://dx.doi.org/10.3390/e24020267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870868PMC
February 2022

Silk Sericin Enrichment through Electrodeposition and Carbonous Materials for the Removal of Methylene Blue from Aqueous Solution.

Int J Mol Sci 2022 Jan 31;23(3). Epub 2022 Jan 31.

State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

The recycling and reuse of biomass waste for the preparation of carbon-based adsorbents is a sustainable development strategy that has a positive environmental impact. It is well known that a large amount of silk sericin (SS) is dissolved in the wastewater from the silk industry. Utilizing the SS instead of discharging it into the environment without further treatment would reduce environmental and ecological problems. However, effective enrichment of the SS from the aqueous solution is a challenge. Here, with the help of carboxymethyl chitosan (CMCS), which can form a gel structure under low voltage, an SS/CMCS hydrogel with SS as the major component was prepared via electrodeposition at a 3 V direct-current (DC) voltage for five minutes. Following a carbonization process, an SS-based adsorbent with good performance for the removal of methylene blue (MB) from an aqueous solution was prepared. Our results reveal that the SS/CMCS hydrogel maintains a porous architecture before and after carbonization. Such structure provides abundant adsorption sites facilitating the adsorption of MB molecules, with a maximum adsorptive capacity of 231.79 mg/g. In addition, it suggests that the adsorption is an exothermic process, has a good fit with the model, and follows the intra-particle diffusion model. The presented work provides an economical and feasible path for the treatment of wastewater from dyeing and printing.
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http://dx.doi.org/10.3390/ijms23031668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836085PMC
January 2022

Long noncoding RNA H19 suppresses cardiac hypertrophy through the MicroRNA-145-3p/SMAD4 axis.

Bioengineered 2022 02;13(2):3826-3839

Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Sustained cardiac hypertrophy (CH) contributes to many heart diseases. Long noncoding RNAs (lncRNAs) collectively play critical roles in cardiovascular diseases (CVDs). However, the roles of lncRNA H19 in CH are still unclear. A CH model was constructed utilizing isoproterenol (ISO). We demonstrated H19 could participate in regulating ISO-induced CH development both and . The online databases DIANA and TargetScan were used to predict the targets of H19 and MicroRNA-145-3p (miR-145-3p), respectively. Luciferase reporter assay was used to verify the downstream targets. The results showed that H19 was decreased under ISO stimulation. The H19 overexpression resulted in significant decrease in mouse heart size and weight, left ventricular systolic dysfunction, left ventricular posterior wall thickness and cardiac hypertrophic growth, while promoted the increase of left ventricular ejection fraction and left ventricle fraction shortening. H19 also inhibited protein expression levels of CH markers, such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and MYH7. Luciferase assays results showed that miR-145-3p was a target of H19 and SMAD4 was a target of miR-145-3p. We found that H19 regulated SMAD4 by sponging miR-145-3p. Knockout of miR-145-3p or overexpression of SMAD4 facilitated H19-induced decreases in ANP, BNP, and MYH7. Collectively, our findings have indicated that the H19/miR-145-3p/SMAD4 axis should be a negative regulator involved in CH progression.
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http://dx.doi.org/10.1080/21655979.2021.2017564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973863PMC
February 2022

Aridity Threshold Induces Abrupt Change of Soil Abundant and Rare Bacterial Biogeography in Dryland Ecosystems.

mSystems 2022 Feb 8;7(1):e0130921. Epub 2022 Feb 8.

State Key Laboratory of Crop Stress Biology in Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, People's Republic of China.

Aridity, which is increasing worldwide due to climate change, affects the biodiversity and functions of dryland ecosystems. Whether aridification leads to gradual (or abrupt) and systemic (or specific) changes in the biogeography of abundant and rare microbial species is largely unknown. Here, we investigated stress-adaptive changes (aridity-driven, ranging from 0.65 to 0.94) and biogeographic patterns of abundant and rare bacterial communities in different habitats, including agricultural field, forest, wetland, grassland, and desert, in desert oasis transition zones in northern China. We observed abrupt changes at the breakpoint of aridity values (0.92), characterized by diversity (α-diversity and β-diversity), species coexistence, community assembly processes, and phylogenetic niche conservatism. Specifically, when aridity was <0.92, increasing aridity led to more deterministic assembly and species coexistences for the abundant subcommunity, whereas the reverse was observed for the rare subcommunity. The phylogenetic niche conservatism for both subcommunities increased slowly with aridity. When aridity was >0.92, the systemic responses of abundant and rare taxa changed dramatically in a consistent direction, such that both subcommunities rapidly tended to have a more deterministic assembly, species coexistence, and stronger phylogenetic niche conservatism with increasing aridity. In addition, the change rates of abundant taxa were higher than those of rare taxa, indicating the more sensitive responses of abundant taxa along aridity variation. This finding has important implications for understanding the impact of aridity on the structure and function of abundant and rare soil taxa and how diversity maintenance is associated with soil microbiota responding to global change. The abrupt threshold of soil bacteria found can be used for buffering and for building effective adaptation and mitigation measures aimed at maintaining the capacity of drylands for basic ecosystem functioning. Aridity, which is increasing worldwide due to climate change, affects the biodiversity and functions of dryland ecosystems. We provided the first statistical evidence for abrupt changes of species coexistence, ecological processes, and niche conservation of abundant and rare soil bacteria triggered by diversity to abrupt increases in aridity. The abrupt threshold of soil bacterial community response to aridity is spatially heterogeneous at the local scale and should be specified according to local conditions for buffering and for building effective adaptation and mitigation measures aimed at maintaining the capacity of drylands for basic ecosystem functioning.
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http://dx.doi.org/10.1128/msystems.01309-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823291PMC
February 2022

Three-dimensional nano assembly of nickel cobalt sulphide/[email protected]/reduced graphene oxide hybrid with superior lithium storage and electrocatalytic properties for hydrogen evolution reaction.

J Colloid Interface Sci 2022 May 29;614:642-654. Epub 2022 Jan 29.

Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China. Electronic address:

Engineering hierarchical nanostructures with enhanced charge storage capacity and electrochemical activity are vital for the advancement of energy devices. Herein, a highly ordered mesoporous three-dimensional (3D) nano-assembly of Nickel Cobalt Sulphide/Polyaniline @Polyoxometalate/Reduced Graphene Oxide (NiCoS/[email protected]/rGO) is prepared first time via a simple route of oxidative polymerization followed by a hydrothermal method. Morphological analysis of the resulting hybrid reveals the sheet-like structures containing a homogeneous assembly of [email protected] and NiCoS on the graphene exterior maintaining huge structural integrity, large surface area and electrochemically active centres. The electrochemical analysis of the nanohybrid as the anode of the lithium-ion battery (LIB) has delivered ultra-huge reversible capacity of 735.5 mA h g (0.1 A g after 200 cycles), superb capacity retention (0.161% decay/per cycle at 0.5 A g for 1000 cycles), and significant rate capability (355.6 mA h g at 2 A g). The hydrogen evolution reaction (HER) measurement also proves remarkable activity, extremely low overpotential and high durability. The extraordinary performance of the nanohybrid is due to the presence of abundant electroactive centres, high surface area and a large number of ion exchange channels. These outstanding results prove the advantages of a combination of NiCoS, graphene sheets, and [email protected] in energy devices.
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http://dx.doi.org/10.1016/j.jcis.2022.01.153DOI Listing
May 2022

The fate of antibiotic resistance genes and their influential factors in swine manure composting with sepiolite as additive.

Bioresour Technol 2022 Mar 19;347:126727. Epub 2022 Jan 19.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, PR China.

Manures are storages for antibiotic resistance genes (ARGs) entering the environment. This study investigated the effects of adding sepiolite at 0%, 2.5%, 5%, and 7.5% (CK, T1, T2, and T3, respectively) on the fates of ARGs during composting. The relative abundances (RAs) of the total ARGs in CK and T3 decreased by 0.23 and 0.46 logs, respectively, after composting. The RAs of 10/11 ARGs decreased in CK, whereas they all decreased in T3. The reduction in the RA of the total mobile genetic elements (MGEs) was 1.26 times higher in T3 compared with CK after composting. The bacterial community accounted for 47.93% of the variation in the abundances of ARGs. Network analysis indicated that ARGs and MGEs shared potential host bacteria (PHB), and T3 controlled the transmission of ARGs by reducing the abundances of PHB. Composting with 7.5% sepiolite is an effective strategy for reducing the risk of ARGs proliferating.
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http://dx.doi.org/10.1016/j.biortech.2022.126727DOI Listing
March 2022

Elucidating the beneficial effects of diatomite for reducing abundances of antibiotic resistance genes during swine manure composting.

Sci Total Environ 2022 May 19;821:153199. Epub 2022 Jan 19.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.

Diatomite (DE) has been used for nitrogen conservation during the composting of feces but its effects on antibiotic resistance genes (ARGs) and the associated mechanisms are still unclear. In this study, DE was added at three different proportions (0%, 4%, and 8%) to swine manure during composting. The results showed that adding DE helped to reduce the abundances of ARGs and the maximum decrease (88.99%) occurred with the highest dose. DE amendment promoted the transformation of reducible copper into a more stable form, i.e., the residual fraction, which reduced the selective pressure imposed by copper and further decreased the abundances of ARGs. Tn916/1545 and intI1 were critical genetic components related to ARGs, and thus the reductions in the abundances of ARGs may be attributed to the suppression of horizontal transfer due to the decreased abundances of mobile genetic elements (MGEs). The microbial community structure (bacterial abundance and diversity) played key role in the evolution of ARGs. DE could enhance the competition between hosts and non-hosts of ARGs by increasing the bacterial community diversity. Compared with CK, DE amendment optimized the bacterial community by reducing the abundances of the potential hosts of ARGs and pathogens such as Corynebacterium, thereby improving the safety of the compost product. In addition, KEGG function predictions revealed that adding DE inhibited the metabolic pathway and genes related to ARGs. Thus, composting with 8% DE can reduce the risk of ARG transmission and improve the practical value for agronomic applications.
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http://dx.doi.org/10.1016/j.scitotenv.2022.153199DOI Listing
May 2022

Single-component color-tunable circularly polarized organic afterglow through chiral clusterization.

Nat Commun 2022 Jan 20;13(1):429. Epub 2022 Jan 20.

State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.

Circularly polarized organic afterglow (CPOA) with both long-lived room-temperature phosphorescence (RTP) and circularly polarized luminescence (CPL) is currently attracting great interest, but the development of multicolor-tunable CPOA in a single-component material remains a formidable challenge. Here, we report an efficient strategy to achieve multicolor CPOA molecules through chiral clusterization by implanting chirality center into non-conjugated organic cluster. Owing to excitation-dependent emission of clusters, highly efficient and significantly tuned CPOA emissions from blue to yellowish-green with dissymmetry factor over 2.3 × 10 and lifetime up to 587 ms are observed under different excitation wavelengths. With the distinguished color-tunable CPOA, the multicolor CPL displays and visual RTP detection of ultraviolent light wavelength are successfully constructed. These results not only provide a new paradigm for realization of multicolor-tunable CPOA materials in single-component molecular systems, but also offer new opportunities for expanding the applicability of CPL and RTP materials for diversified applications.
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http://dx.doi.org/10.1038/s41467-022-28070-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776763PMC
January 2022

Silica-Bacterial Cellulose Composite Aerogel Fibers with Excellent Mechanical Properties from Sodium Silicate Precursor.

Gels 2021 Dec 26;8(1). Epub 2021 Dec 26.

School of Chemistry and Chemical Engineering, Inner Mongolia University of Science & Technology, Baotou 014010, China.

Forming fibers for fabric insulation is difficult using aerogels, which have excellent thermal insulation performance but poor mechanical properties. A previous study proposed a novel method that could effectively improve the mechanical properties of aerogels and make them into fibers for use in fabric insulation. In this study, composite aerogel fibers (CAFs) with excellent mechanical properties and thermal insulation performance were prepared using a streamlined method. The wet bacterial cellulose (BC) matrix without freeze-drying directly was immersed in an inorganic precursor (silicate) solution, followed by initiating in situ sol-gel reaction under the action of acidic catalyst after secondary shaping. Finally, after surface modification and ambient drying of the wet composite gel, CAFs were obtained. The CAFs prepared by the simplified method still had favorable mechanical properties (tensile strength of 4.5 MPa) and excellent thermal insulation properties under extreme conditions (220 °C and -60 °C). In particular, compared with previous work, the presented CAFs preparation process is simpler and more environmentally friendly. In addition, the experimental costs were reduced. Furthermore, the obtained CAFs had high specific surface area (671.3 m²/g), excellent hydrophobicity, and low density (≤0.154 g/cm). This streamlined method was proposed to prepare aerogel fibers with excellent performance to meet the requirements of wearable applications.
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http://dx.doi.org/10.3390/gels8010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774922PMC
December 2021

Bisphenol S exposure accelerates the progression of atherosclerosis in zebrafish embryo-larvae.

J Hazard Mater 2022 03 9;426:128042. Epub 2021 Dec 9.

College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao 266003, China. Electronic address:

Bisphenol S (BPS), widely utilized in manufacturing of daily necessities, is a toxicant with potential to induce atherosclerotic cardiovascular disease (ASCVD). However, the mode of action by which BPS exposure induces ASCVD remains unknown. Here, macrophages that were exposed to BPS in combination with oxidized low-density lipoprotein (oxLDL) exhibited enhanced formation of foam cells, a hallmark of ASCVD. Furthermore, zebrafish embryo-larvae were exposed to BPS (0, 1, 10 and 100 μg/L) for 15 days (d) and the characteristic symptoms of ASCVD including an inflammatory response, macrophage recruitment around blood vessels, and accumulation of oxLDL on vascular endothelium, were induced in 15-d larvae. After zebrafish were exposed to BPS for 45 d, BPS mobilized fatty acid metabolism and activated peroxisome proliferator-activated receptor signaling in larval liver, the hub of endogenous lipid metabolism, causing an increase in plasma LDL. Driven by high plasma LDL levels, the caudal artery of zebrafish larvae exhibited lipid accumulation and a thickened area with a large number of collagen fibers, accompanied by characteristic lesions, as well as hyperlipidemia, erythrocyte aggregation, thinner blood vessel walls and increased levels of leukocytes and thromboocytes in plasma. Our data demonstrate that BPS accelerates the progression of ASCVD using zebrafish embryo-larvae as a model.
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http://dx.doi.org/10.1016/j.jhazmat.2021.128042DOI Listing
March 2022
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