Publications by authors named "Jie Cao"

841 Publications

A survival comparison of gastric mucin-producing adenocarcinoma to conventional adenocarcinoma: a SEER database analysis.

BMC Cancer 2021 Oct 23;21(1):1138. Epub 2021 Oct 23.

The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.

Background: Compared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually separated from other histological types and has been evaluated separately. The objective was to compare the clinicopathological characteristics and survivals of MPA with CA.

Methods: We retrospectively analyzed 1515 MPA patients in SEER database. Log-rank tests and KM survival curves were applied to determine the differences in overall survival (OS) and cancer specific survival (CSS) time.

Results: No significant differences were noted in OS and CSS time. The MPA patients who were treated with surgery and chemotherapy exhibited longer OS and CSS time periods than those without treatment. MPA patients treated with radiotherapy exhibited similar OS and CSS time with those without radiotherapy. MPA was not a prognostic factor of survival.

Conclusions: MPA was a rare histological type of gastric cancer. Patients with MPA exhibited similar prognosis with those with CA. Surgery and chemotherapy were effective treatments for patients with MPA.
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http://dx.doi.org/10.1186/s12885-021-08835-zDOI Listing
October 2021

Identification of the age of white tea using proton transfer reaction-time of flight-mass spectrometry (PTR-TOF-MS) coupled with multivariate analysis.

Rapid Commun Mass Spectrom 2021 Oct 23:e9215. Epub 2021 Oct 23.

College of Environment and Resources, Fuzhou University, Fuzhou, Fujian, China.

Rationale: In recent years, white tea has become increasingly popular. Some merchants confuse the age of white tea and sell poor-quality products for profit. Therefore, it is necessary to provide technical support for product authentication and valorization in white tea of different marked ages.

Methods: Volatile organic compounds (VOCs) were detected by proton transfer reaction time of flight-mass spectrometry (PTR-TOF-MS) and identified as volatile fingerprints. PTR-TOF-MS combined with multivariate analysis was found to identify white tea of four different marked ages (1, 3, 5, and 8 years) for authentication. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used as classification models to identify key volatile metabolites.

Results: The OPLS-DA model achieved the best result (96.67%, 96.67%,96.67%, and 96.67% in the training set and 96.00%,96.00%, 100% and 100% in the prediction set for 1-year, 3-year, 5-year and 8-year tea samples, respectively), showing that PTR-TOF-MS with the OPLS-DA model could successfully be used in the identification of white tea with different marked ages. Out of the 60 identified volatile organic compounds, 26 volatile materials were closely correlated with tea age and were used as markers to discriminate white tea of different ages.

Conclusions: PTR-TOF-MS coupled with multivariate analysis could be applied for quality evaluation of tea products of different ages and provided a feasible technical support for product authentication and valorization in white tea of different marked ages.
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http://dx.doi.org/10.1002/rcm.9215DOI Listing
October 2021

Demonstration of Controlled Hydrogen Release Using [email protected] during Hydrolysis of NHBH.

ACS Appl Mater Interfaces 2021 Oct 15. Epub 2021 Oct 15.

Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang City 443002 Hubei Province, People's Republic of China.

Achieving the controlled release of H through an effective approach still faces many challenges. Herein, high-quality graphene quantum dots (GQDs) are synthesized from a new precursor, 1,2,4-trihydroxy benzene, and a multifunctional platform of [email protected] is further developed for the controlled H evolution upon the hydrolysis of NHBH (AB). More importantly, the designing concepts of multistep and stepless speed controls have been introduced in the domains of both H evolution for the first time. Through a novel designing protocol, the rate of H evolution can be freely regulated and constantly varied on demand by means of chelation between Zn and ethylene diamine tetraacetic acid (EDTA). The density functional theory calculation indicates that Zn has the priority to be adsorbed onto Rh(100) due to its larger adsorption energy (107.98 kcal·mol) than that of AB (36.36 kcal·mol). A controlling mechanism is presented such that Zn will cover the active sites of the nanocatalyst to prevent the H evolution, and EDTA can chelate Zn to reactivate the nanocatalyst for the production of H, greatly facilitating use of this strategy in other catalytic reactions. Moreover, it is demonstrated that the protocol is equally valid for diverse hydrogen storage materials. Therefore, this work not only establishes whole new concepts for the controlled production of H but also explains their mechanism, thus remarkably advancing the utilization of H energy and significantly enlightening the controlled process of catalysis.
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http://dx.doi.org/10.1021/acsami.1c15660DOI Listing
October 2021

Corrigendum: The Tick Microbiota Dysbiosis Promote Tick-Borne Pathogen Transstadial Transmission in a Infected Mouse Model.

Front Cell Infect Microbiol 2021 27;11:765387. Epub 2021 Sep 27.

Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.

[This corrects the article DOI: 10.3389/fcimb.2021.713466.].
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http://dx.doi.org/10.3389/fcimb.2021.765387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504646PMC
September 2021

Complementary Fourier Single-Pixel Imaging.

Sensors (Basel) 2021 Sep 30;21(19). Epub 2021 Sep 30.

Beijing Fisheries Research Institute, Beijing 100068, China.

Single-pixel imaging, with the advantages of a wide spectrum, beyond-visual-field imaging, and robustness to light scattering, has attracted increasing attention in recent years. Fourier single-pixel imaging (FSI) can reconstruct sharp images under sub-Nyquist sampling. However, the conventional FSI has difficulty balancing imaging quality and efficiency. To overcome this issue, we proposed a novel approach called complementary Fourier single-pixel imaging (CFSI) to reduce the number of measurements while retaining its robustness. The complementary nature of Fourier patterns based on a four-step phase-shift algorithm is combined with the complementary nature of a digital micromirror device. CFSI only requires two phase-shifted patterns to obtain one Fourier spectral value. Four light intensity values are obtained by loading the two patterns, and the spectral value is calculated through differential measurement, which has good robustness to noise. The proposed method is verified by simulations and experiments compared with FSI based on two-, three-, and four-step phase shift algorithms. CFSI performed better than the other methods under the condition that the best imaging quality of CFSI is not reached. The reported technique provides an alternative approach to realize real-time and high-quality imaging.
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http://dx.doi.org/10.3390/s21196544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512370PMC
September 2021

Polymorphonuclear neutrophils promote endothelial apoptosis by enhancing adhesion upon stimulation by intermittent hypoxia.

Sleep Breath 2021 Oct 11. Epub 2021 Oct 11.

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.

Purpose: This study explored the interactive effects between polymorphonuclear neutrophils (PMNs) and vascular endothelial cells under intermittent hypoxia (IH) and investigated the mechanisms underlying these effects.

Methods: Endothelial cells were co-cultured with PMNs isolated from rats exposed to normoxia or IH. The PMN apoptotic rate was determined using flow cytometry. Expression of apoptosis-related proteins in the endothelial cells were evaluated using Western blotting, and the levels of intercellular adhesion molecules in the co-culture supernatants were measured using enzyme-linked immunosorbent assay.

Results: The PMN apoptotic rate in the IH-exposed rat group was significantly lower than that of the normoxia control group. There was a positive relationship between the PMN apoptotic rate and IH exposure time. In endothelial cells co-cultured with PMNs isolated from IH-exposed rats, a significant increase in the protein expression levels of Bax, Bcl-2, and caspase-3 and a significant decrease in the Bcl-2/Bax ratio were observed. Furthermore, the intercellular cell adhesion molecule-1(ICAM-1) and E-select element (E-S) levels were elevated significantly in the co-cultured supernatants of endothelial cells and PMNs from IH-exposed rats compared to that from controls. The above IH-induced alterations were partially restored by tempol pretreatment.

Conclusions: The apoptotic rate was low in PMNs from IH-exposed rats, which consequently increased the apoptotic signals in endothelial cells in vitro. This may be associated with the increased levels of intercellular adhesion molecules. Further, tempol partially attenuates the PMN-mediated pro-apoptotic effects on endothelial cells under IH.
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http://dx.doi.org/10.1007/s11325-021-02503-zDOI Listing
October 2021

Hemorrhagic transformation after acute ischemic stroke caused by polycythemia vera: Report of two case.

World J Clin Cases 2021 Sep;9(25):7551-7557

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.

Background: Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by an increase in red blood cells in the peripheral blood. Previous work has reported the occurrence of thrombosis or hemorrhage arising in the cerebral vasculature secondary to PV. However, hemorrhagic transformation after PV-associated acute ischemic stroke has not been previously described.

Case Summary: We herein present two cases of PV where hemorrhagic transformation occurred after an acute ischemic stroke. Case 1 was a 57-year-old woman with a history of hypertension who was admitted for left-sided weakness. Case 2 was a 68-year-old man who was admitted for a 10-d sudden left arm weakness. Imaging examinations for the two patients revealed hemorrhagic transformation after acute ischemic stroke. Both patients had JAK-2-V617F mutation and received antiplatelet therapy. Both of them had a good prognosis during the follow-up.

Conclusion: This report suggested that hemorrhagic transformation may occur in acute ischemic stroke caused by PV. Antiplatelet drugs do not seem to influence the long-term outcomes in such patients. Future research should focus on establishing a standard antiplatelet treatment strategy for this condition.
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http://dx.doi.org/10.12998/wjcc.v9.i25.7551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464450PMC
September 2021

The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer.

Front Oncol 2021 16;11:685577. Epub 2021 Sep 16.

School of Medicine, South China University of Technology, Guangzhou, China.

Objective: The mesentery is a potential site of residual tumor in patients with colorectal cancer (CRC). However, the mesenteric immune microenvironment remains unclear. In this study, we investigated the immune landscape of the mesentery, particularly the role of lymphocytes and its association with the clinicopathological characteristics of CRC.

Methods: Flow cytometry was used to detect lymphocytes in the paired mesenteric tissue specimens adjacent to the colorectal tumors and normal mesenteric tissue specimens 10 cm away from the colorectal tumor edge and preoperative peripheral blood samples obtained from patients with CRC who underwent surgery. T-distributed stochastic neighbor embedding was utilized to analyze multiparameter flow cytometry data. Multiplex immunohistochemistry was performed to evaluate T cells subsets in the paired mesentery adjacent to the colorectal tumors and normal mesentery. The Fisher's exact test and non-parametric Wilcoxon's matched-pairs tests were used for statistical analysis. The non-parametric Mann-Whitney U test was used to determine associations between percentage data and clinical parameters of patients with CRC.

Results: We found that immune cells in the normal mesentery were mainly of lymphoid lineage. Compared with peripheral blood, the normal mesentery showed decreased NK cells and the CD4/CD8 ratio and increased CD3 CD56, memory CD4 T, memory CD8 T, CD4 tissue-resident memory T (TRM), and CD8 TRM cells. Compared with the normal mesentery, the mesentery adjacent to the colorectal tumor showed increased B and regulatory T cells and decreased NK, CD3 CD56, CD4 TRM, and CD8 TRM cells. Moreover, memory CD8 T cells and plasmablasts are negatively correlated with the depth of invasion of CRC. Increased memory CD4 T cells are associated with distant metastasis of CRC and high preoperative serum carcinoembryonic antigen levels.

Conclusion: The mesentery shows a specific immune microenvironment, which differs from that observed in peripheral blood. CRC can alter the mesenteric immune response to promote tumor progression.
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http://dx.doi.org/10.3389/fonc.2021.685577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481834PMC
September 2021

Bifunctional alginate/chitosan stabilized perfluorohexane nanodroplets as smart vehicles for ultrasound and pH responsive delivery of anticancer agents.

Int J Biol Macromol 2021 Sep 30. Epub 2021 Sep 30.

Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory School of Medicine, Atlanta, GA 30332, USA.

The combination of ultrasound and chemotherapy has been proposed as a promising strategy to achieve a better anticancer therapeutic efficacy. Here we present a facile strategy to construct novel bifunctional nanodroplets as smart vehicles for ultrasound and pH responsive delivery of anticancer agents. PFH is used as core and chitosan/alginate complexes are used as the stable shells of the nanodroplets. The effects of alginate/chitosan ratio, and the amount of surfactant as well as PFH on the size, size distribution, and encapsulation efficiency of nanodroplets are systematically investigated with the optimized formulation identified. The release of the encapsulated doxorubicin hydrochloride can be triggered by changing the pH value of the surrounding environment and the exposure to ultrasound. The nanodroplets also show strong ultrasound contrast via droplet-to-bubble transition as demonstrated by B-mode ultrasound imaging. The hemolytic activity and cytotoxicity are further studied, revealing the biocompatibility of the nanodroplets. The in vivo antitumor results demonstrate that the prepared droplets show excellent antitumor therapeutic efficacy and outstanding tumor-targeting ability. The proposed alginate/chitosan stabilized PFH nanodroplets represent an important advance in fabricating multifunctional therapeutic materials with great promises in the applications of combined antitumor therapies.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.09.166DOI Listing
September 2021

Biomimetic phototherapy in cancer treatment: from synthesis to application.

Drug Deliv 2021 Dec;28(1):2085-2099

Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, PR China.

Phototherapy, with minimally invasive and cosmetic effect, has received considerable attention and been widely studied in cancer treatment, especially in biomaterials field. However, most nanomaterials applied for the delivery of phototherapy agents are usually recognized by the immune system or cleared by liver and kidney, thus hindering their clinical applications. To overcome these limitations, bionic technology stands out by virtue of its low antigenicity and targeting properties, including membrane bionics and bionic enzymes. In this review, we will summarize the up-to-date progress in the development of biomimetic camouflage-based nanomaterials for phototherapy, from synthesis to application, and their future in cancer treatment.
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http://dx.doi.org/10.1080/10717544.2021.1983082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491738PMC
December 2021

Identification of autophagy-related genes in idiopathic pulmonary fibrosis using bioinformatics methods.

Chin Med J (Engl) 2021 Sep 22. Epub 2021 Sep 22.

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.

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http://dx.doi.org/10.1097/CM9.0000000000001633DOI Listing
September 2021

Associations of tea consumption with blood pressure progression and hypertension incidence.

J Geriatr Cardiol 2021 Aug;18(8):645-653

Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Association between tea consumption and incident hypertension remains uncertain. This study conducted to examine the health effects of tea consumption on blood pressure progression and hypertension incidence.

Methods: A population-based cohort of 38,913 Chinese participants without hypertension at baseline were included in the current study. Information on tea consumption was collected through standardized questionnaires. Associations of tea consumption with blood pressure progression and incident hypertension were analyzed using logistic regression models and Cox proportional hazards regression models, respectively.

Results: During a median follow-up of 5.9 years, 17,657 individuals had experienced progression to a higher blood pressure stage and 5,935 individuals had developed hypertension. In multivariate analyses, habitual tea drinkers (≥ 3 times/week for at least six months) had a 17% lower risk for blood pressure progression [odds ratio (OR) = 0.83, 95% CI: 0.79-0.88] and a 14% decreased risk for incident hypertension [hazard ratio (HR) = 0.86, 95% CI: 0.80-0.91] compared with non-habitual tea drinkers. Individuals in different baseline blood pressure groups could obtain similar benefit from habitual tea drinking. In terms of tea consumption amount, an inverse, linear dose-response relation between monthly consumption of tea leaves and risk of blood pressure progression was observed, while the risk of incident hypertension did not reduce further after consuming around 100 g of tea leaves per month.

Conclusions: Our study demonstrated that habitual tea consumption could provide preventive effect against blood pressure progression and hypertension incidence.
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http://dx.doi.org/10.11909/j.issn.1671-5411.2021.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390932PMC
August 2021

Microgel Single-Cell Culture Arrays on a Microfluidic Chip for Selective Expansion and Recovery of Colorectal Cancer Stem Cells.

Anal Chem 2021 09 8;93(37):12628-12638. Epub 2021 Sep 8.

School of Medicine, South China University of Technology, Guangzhou 510006, China.

Cancer stem cells (CSCs) are rare and lack definite biomarkers, necessitating new methods for a robust expansion. Here, we developed a microfluidic single-cell culture (SCC) approach for expanding and recovering colorectal CSCs from both cell lines and tumor tissues. By incorporating alginate hydrogels with droplet microfluidics, a high-density microgel array can be formed on a microfluidic chip that allows for single-cell encapsulation and nonadhesive culture. The SCC approach takes advantage of the self-renewal property of stem cells, as only the CSCs can survive in the SCC and form tumorspheres. Consecutive imaging confirmed the formation of single-cell-derived tumorspheres, mainly from a population of small-sized cells. Through on-chip decapsulation of the alginate microgel, ∼6000 live cells can be recovered in a single run, which is sufficient for most biological assays. The recovered cells were verified to have the genetic and phenotypic characteristics of CSCs. Furthermore, multiple CSC-specific targets were identified by comparing the transcriptomics of the CSCs with the primary cancer cells. To summarize, the microgel SCC array offers a label-free approach to obtain sufficient quantities of CSCs and thus is potentially useful for understanding cancer biology and developing personalized CSC-targeting therapies.
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http://dx.doi.org/10.1021/acs.analchem.1c02335DOI Listing
September 2021

Activated carbon as an insoluble electron shuttle to enhance the anaerobic ammonium oxidation coupled with Fe(III) reduction process.

Environ Res 2021 Sep 4;204(Pt A):111972. Epub 2021 Sep 4.

Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.

Anaerobic ammonium oxidation coupled with Fe(III) reduction (Feammox) is an autotrophic biological nitrogen removal (BNR) technique in treating low-C/N wastewater. However, the nitrogen removal rate of Feammox is limited by the extracellular electron transfer. In this study, wood activated carbon (AC) was chosen as electron shuttle to enhance the start-up of the Feammox process. Within an operational period of 150 days, the NH-N removal efficiency reached 97.9-99.5% with a volumetric loading rate (VLR) of 0.04-0.06 kg N m d. Batch experiments indicated that compared with FeO-AQDS and FeO groups, FeO-AC group showed higher catalytic performance and TN removal efficiency reached 85.7%. Quinone (CO) and phenolic (-OH) chemical groups of AC were equipped with electron transfer capacity (76.51 ± 9.27 μmol e g). Moreover, Fe(II)/Fe(III) species and the secondary iron minerals were found in our system. Microbial analysis showed that Proteobacteria and Acidobacteriota, which observed with relatively high abundance, were played an important role in the integrated Feammox system. This study demonstrates the significant influence of AC on Feammox process and provides an enhanced biological nitrogen removal strategy for practice engineering application.
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http://dx.doi.org/10.1016/j.envres.2021.111972DOI Listing
September 2021

Treatment of rheumatoid arthritis by phototherapy: advances and perspectives.

Nanoscale 2021 Sep 17;13(35):14591-14608. Epub 2021 Sep 17.

Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266021, China.

Rheumatoid arthritis (RA) is an inflammatory disease that is prevalent worldwide and seriously threatens human health. Though traditional drug therapy can alleviate RA symptoms and slow progression, high dosage and frequent administration would cause unfavorable side effects. Phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT) has demonstrated distinctive potential in RA treatment. Under light irradiation, phototherapy can convert light into heat, or generate ROS, to promote necrosis or apoptosis of RA inflammatory cells, thus reducing the concentration of related inflammatory factors and relieving the symptoms of RA. In this review, we will summarize the development in the application of phototherapy in the treatment of rheumatoid arthritis.
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http://dx.doi.org/10.1039/d1nr03623hDOI Listing
September 2021

Tunable lens using dielectric elastomer sandwiched by transparent conductive liquid.

Opt Lett 2021 Sep;46(17):4430-4433

We propose and demonstrate a compact tunable lens with high transmittance using a dielectric elastomer sandwiched by transparent conductive liquid. The transparent conductive liquid not only serves as the refractive material of the tunable lens but also works as the compliant electrode of the dielectric elastomer. The overall dimensions of the proposed tunable lens are 16 mm in diameter and 10 mm in height, and the optical transmittance is as high as 92.2% at 380-760 nm. The focal power variation of the tunable lens is -23.71 at an actuation voltage of 3.0 kV. The rise and fall times are 60 ms and 185 ms, respectively. The fabrication process of the tunable lens is free of the deposition of opaque compliant electrodes. Such a tunable lens promises a potential solution in various compact imaging systems.
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http://dx.doi.org/10.1364/OL.437644DOI Listing
September 2021

Multivalent effects of heptamannosylated β-cyclodextrins on macrophage polarization to accelerate wound healing.

Colloids Surf B Biointerfaces 2021 Aug 26;208:112071. Epub 2021 Aug 26.

Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Electronic address:

Macrophages have high plasticity and heterogeneity, and can suppress or mediate inflammation, depending on their cytokine secretion and phenotype. Regulating macrophage polarization into its M2 phenotype has a remarkable effect on inflammatory inhibition, inducing the regeneration of injured tissues. Here, we synthesized two heptamannosylated β-cyclodextrin derivatives (CD-Man7 and C-CD-Man7) and demonstrated that their multivalent mannose ligands could induce M2 macrophage polarization to accelerate wound healing. Unlike hydrophilic CD-Man7, amphiphilic C-CD-Man7 can self-assemble to form nanoparticles (CD-Man-NPs) in aqueous solution. Further, in vitro results confirmed that multivalent mannose ligands of either CD-Man7 or CD-Man-NPs stimulated RAW264.7 macrophages to differentiate into the M2 phenotype, which promoted fibroblast migration via a paracrine mechanism. In vivo results confirmed that both CD-Man7 and CD-Man-NPs reduced the inflammatory response in wound tissue and accelerated wound healing. The present study demonstrates multivalent effects of CD-Man7 and CD-Man-NPs on M2 macrophage polarization, indicating the therapeutic potential of these β-cyclodextrin glycoconjugates in the treatment of inflammatory diseases and wound healing.
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http://dx.doi.org/10.1016/j.colsurfb.2021.112071DOI Listing
August 2021

Benefits of active commuting on cardiovascular health modified by ambient fine particulate matter in China: A prospective cohort study.

Ecotoxicol Environ Saf 2021 Aug 27;224:112641. Epub 2021 Aug 27.

Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Background: Active commuting as a contributor to daily physical activity is beneficial for cardiovascular health, but leads to more chances of exposure to ambient air pollution. This study aimed to investigate associations between active commuting to work with cardiovascular disease (CVD), mortality and life expectancy among general Chinese adults, and to further evaluate the modification effect of fine particulate matter (PM) exposure on these associations.

Methods: We included 76,176 Chinese adults without CVD from three large cohorts of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project. Information about commuting mode and physical activity were collected by unified questionnaire. Satellite-based PM concentrations at 1-km spatial resolution was used for estimating PM exposure of participants. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD incidence, mortality and all-cause mortality were estimated using Cox proportional hazards regression models. Multiplicative interaction term of commuting mode and PM level was tested to investigate potential effect modification.

Results: During 448,499 person-years of follow-up, 2230 CVD events and 2777 all-cause deaths were recorded. Compared with the non-active commuters, the multivariable-adjusted HRs (95% CIs) of CVD incidence and all-cause mortality were 0.95(0.85-1.05) and 0.79(0.72-0.87) for walking commuters, respectively. Corresponding HRs (95% CIs) for cycling commuters were 0.71(0.62-0.82) and 0.67(0.59-0.76). Active commuters over 45 years old were estimated to have more CVD-free years and life expectancy than non-active commuters under lower PM concentration. However, these beneficial effects of active commuting were alleviated or counteracted by long-term exposure to high PM concentration. Significant multiplicative interaction of commuting mode and PM level was showed in all-cause mortality, with the lowest risk observed in cycling participants exposed to lower level of PM.

Conclusions: Active commuting was associated with lower risk of CVD, all-cause mortality, and longer life expectancy among Chinese adults under ambient settings with lower PM level. It will be valuable to encourage active commuting among adults and develop stringent strategies on ambient PM pollution control for prevention of CVD and prolongation of life expectancy.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112641DOI Listing
August 2021

Transport and Recovery of Turbot () Sedated with MS-222 and Eugenol: Effects on Intermediary Metabolism and Osmoregulation.

Animals (Basel) 2021 Jul 29;11(8). Epub 2021 Jul 29.

College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

This study focused on the anesthetic waterless keep-alive transport technique for turbot. MS-222 and eugenol were used to anesthetize turbot and then the waterless keep-alive transport was conducted. The blood physiological changes and flesh quality changes of turbot were evaluated after cooling and during the simulated waterless transport. The results show that the temperature lowered from 13 to 2 °C, resulting in a decrease in moisture, fat and protein contents of all samples. Compared to the control turbot, the turbots treated with MS-222 and eugenol presented higher pH and glycogen content. During the simulated waterless transport, the pH, ATP and glycogen contents in MS-222- and eugenol-treated turbots decreased and the IMP and lactate levels increased. For the blood biochemical indices, blood glucose, cortisol and urea nitrogen increased with the increase in transport time in MS-222- and eugenol-treated turbots. At sampling time, the changes in blood physiological indices were significantly higher in the control samples than those in the MS-222- and eugenol-treated samples. The results indicate that the turbot samples treated with MS-222 or eugenol could reduce stress during cooling and simulated waterless transport.
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http://dx.doi.org/10.3390/ani11082228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388431PMC
July 2021

Clinical efficacy of an enhanced recovery after surgery protocol in patients undergoing robotic-assisted laparoscopic prostatectomy.

J Int Med Res 2021 Aug;49(8):3000605211033173

Nursing Department, Affiliated Changhai Hospital of Naval Medical University, Shanghai, China.

Objective: To evaluate the application of an enhanced recovery after surgery (ERAS) protocol in patients undergoing robot-assisted laparoscopic prostatectomy (RALP).

Methods: We conducted a retrospective cohort study of 136 patients who underwent RALP between August 2017 and June 2018 as the control group and a prospective analysis of 106 patients who underwent RALP between January 2019 and January 2020 as the ERAS group. ERAS focused on preoperative education, nutritional intervention, electrolyte solution intake, restrictive fluid infusion, body warming, no indwelling central venous catheter, use of nonsteroidal anti-inflammatory drugs (NSAIDs), early mobilization, and eating recovery.

Results: The times from RALP to the first intake of clear liquid; first ambulation; first defecation; first fluid, semi-liquid, and general diet; drain removal; and length of hospital stay (LOS) were significantly shorter, and operative time, fluid infusion within 24 hours, postoperative day (POD) 1 albumin, POD 1 hemoglobin, and POD 2 drainage were significantly higher in the ERAS group. Five patients (3.8%) in the ERAS group developed postoperative complications (urine leakage, n = 4; intestinal obstruction, n = 1), while 1 patient (0.7%) in the control group developed intestinal obstruction.

Conclusions: ERAS effectively accelerated patient rehabilitation and reduced the LOS for patients undergoing RALP.
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http://dx.doi.org/10.1177/03000605211033173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385594PMC
August 2021

The Tick Microbiota Dysbiosis Promote Tick-Borne Pathogen Transstadial Transmission in a -Infected Mouse Model.

Front Cell Infect Microbiol 2021 3;11:713466. Epub 2021 Aug 3.

Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.

Ticks are obligate hematophagous ectoparasites. They are important vectors for many pathogens, of both medical and veterinary importance. Antibiotic residues in animal food are known, but very little is known about the effects of antibiotic residues in animals on the microbiome diversity of ticks and tick-borne pathogen transmission. We used a -infested mouse model to evaluate the effect of antibiotic usage on tick microbiome. Nymphal ticks were fed on an antibiotic cocktail-treated or water control mice. Adult ticks molted from nymphs fed on the antibiotic cocktail-treated mouse had a dysbiosed microbiota. Nymphal ticks were also fed on a -infected mice that had been treated with antibiotic cocktail or water. We found that the infection in adult ticks with a dysbiosed microbiota (44.7%) was increased compared with the control adult ticks (24.2%) by using qPCR targeting 18S rRNA gene. This may increase the risk of tick-borne pathogens (TBPs) transmission from adult ticks to a vertebrate host. These results show that an antibiotic-treated mouse can induce tick microbiota dysbiosis. Antibiotic treatment of -infected mouse poses the possibility of increasing transstadial transmission of from the nymph to the adult . These findings suggest that transmission may be exacerbated in high antibiotic usage areas.
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http://dx.doi.org/10.3389/fcimb.2021.713466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369883PMC
August 2021

Prediction of Genetic Factors of Hyperthyroidism Based on Gene Interaction Network.

Front Cell Dev Biol 2021 2;9:700355. Epub 2021 Aug 2.

Department of Thyroid Surgery, School of Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.

The number of hyperthyroidism patients is increasing these years. As a disease that can lead to cardiovascular disease, it brings great potential health risks to humans. Since hyperthyroidism can induce the occurrence of many diseases, studying its genetic factors will promote the early diagnosis and treatment of hyperthyroidism and its related diseases. Previous studies have used genome-wide association analysis (GWAS) to identify genes related to hyperthyroidism. However, these studies only identify significant sites related to the disease from a statistical point of view and ignore the complex regulation relationship between genes. In addition, mutation is not the only genetic factor of causing hyperthyroidism. Identifying hyperthyroidism-related genes from gene interactions would help researchers discover the disease mechanism. In this paper, we purposed a novel machine learning method for identifying hyperthyroidism-related genes based on gene interaction network. The method, which is called "RW-RVM," is a combination of Random Walk (RW) and Relevance Vector Machines (RVM). RW was implemented to encode the gene interaction network. The features of genes were the regulation relationship between genes and non-coding RNAs. Finally, multiple RVMs were applied to identify hyperthyroidism-related genes. The result of 10-cross validation shows that the area under the receiver operating characteristic curve (AUC) of our method reached 0.9, and area under the precision-recall curve (AUPR) was 0.87. Seventy-eight novel genes were found to be related to hyperthyroidism. We investigated two genes of these novel genes with existing literature, which proved the accuracy of our result and method.
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http://dx.doi.org/10.3389/fcell.2021.700355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365469PMC
August 2021

Study on sialic acid binding state in stewed bird's nest and optimization of enzymatic extraction of free and oligosaccharide-bound sialic acid.

J AOAC Int 2021 Aug 17. Epub 2021 Aug 17.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.

Background: As a traditional Chinese health food, edible bird's nest (EBN) has high medicinal value, which is mostly attributed to the high content of sialic acid (SA). SA mainly exists in protein-bound, oligosaccharide-bound and free forms and the binding forms of SA are closely related to the functions of EBN.

Objective: To establish a simple but robust method to distinguish and determinate the free and oligosaccharide-bound SA content and the protein-bound SA content, and investigate the changes of SA binding state in EBN during different processing.

Methods: Protein-bound SA in EBN was separated from other forms of SA by trichloroacetic acid precipitation, and SA content was determined by high performance liquid chromatography (HPLC). The effects of stewing conditions on the distribution of SA in EBN were investigated and response surface methodology was used to explore the optimal conditions for enzymatic extraction of free and oligosaccharide-bound SA from EBN.

Results: The average recoveries of free and oligosaccharide-bound SA and protein-bound SA were 97.82%-98.92% and 94.67%-95.75%. The content of free and oligosaccharide-bound SA in stewed EBN was proportional to the stewing temperature, stewing time and liquid to material ratio, while that of protein-bound SA was inversely proportional to those factors. Through response surface analysis, we found that the optimum technological parameters were as follows: liquid to material ratio was 60: 1, enzymolysis time was 2 h, enzyme dosage was 12000 U/g (alkaline protease), pH was 11, enzymolysis temperature was 60 °C.

Conclusion: This method can not only distinguish free and oligosaccharide-bound SA and protein-bound SA effectively, but also determine the contents of them. The results of investigation on stewing conditions and response surface analysis can be used as the theoretical basis for the further pharmacological research of EBN, and can also provide theoretical guidance for the development of EBN products.

Highlights: A method for the determination of free and oligosaccharide-bound SA and protein-bound SA in EBN by HPLC was established, and the extraction process of free and oligosaccharide-bound SA was optimized.
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http://dx.doi.org/10.1093/jaoacint/qsab096DOI Listing
August 2021

Nerve ultrasound evaluation of Guillain-Barré syndrome subtypes in northern China.

Muscle Nerve 2021 Nov 21;64(5):560-566. Epub 2021 Aug 21.

Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China.

Introduction/aims: Ultrasound (US) studies have demonstrated patchy enlargement of spinal and peripheral nerves in Guillain-Barré syndrome (GBS). However, whether ultrasound yields useful information for early classification of GBS has not been established. We aimed to evaluate nerve ultrasound in patients with GBS in northern China and compare the sonographic characteristics between demyelinating and axonal subtypes.

Methods: Between November 2018 and October 2019, 38 hospitalized GBS patients within 3 wk of disease onset and 40 healthy controls were enrolled. Ultrasonographic cross-sectional areas (CSA) of the peripheral nerves, vagus nerve, and cervical nerve roots were prospectively recorded in GBS subtypes and controls.

Results: Ultrasonographic CSA exhibited significant enlargement in most patients' nerves compared with healthy controls, most prominent in cervical nerves. The CSA tended to be larger in acute inflammatory demyelinating polyneuropathy (AIDP) than in acute motor axonal neuropathy (AMAN)/acute motor and sensory axonal neuropathy (AMSAN), especially in cervical nerves (C5: 5.9 ± 1.6 mm vs. 7.0 ± 1.7 mm , p = .042; C6: 10.5 ± 1.8 mm vs. 12.0 ± 2.1 mm , p = .033). The chi-squared test revealed significant differences in nerve enlargement in C5 (p < .001), C6 (p < .001), the proximal median nerve (p < .001), and the vagus nerve (p = .003) between GBS and controls. The vagus nerve was larger in patients with autonomic dysfunction than in patients without it (2.3 ± 1.0 mm vs. 1.4 ± 0.5 mm , p = .003).

Discussion: The demyelinating subtype presented with more significant cervical nerve enlargement in GBS. Vagus nerve enlargement may be a useful marker for autonomic dysfunction.
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http://dx.doi.org/10.1002/mus.27386DOI Listing
November 2021

Identification of the Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and their function in the degeneration of tick salivary glands.

Parasit Vectors 2021 Aug 4;14(1):386. Epub 2021 Aug 4.

Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.

Background: The salivary glands of female ticks degenerate rapidly by apoptosis and autophagy after feeding. Bcl-2 family proteins play an important role in the apoptosis pathways, but the functions of these proteins in ticks are unclear. We studied Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and determined their functions in the degeneration of the salivary glands.

Methods: Two molecules containing conserved BH (Bcl-2 family homology) domains were identified and named RhBcl-2 and RhBax. After protein purification and mouse immunization, specific polyclonal antibodies (PcAb) were created in response to the recombinant proteins. Reverse transcription quantitative PCR (RT-qPCR) and western blot were used to detect the presence of RhBcl-2 and RhBax in ticks. TUNEL assays were used to determine the level of apoptosis in the salivary glands of female ticks at different feeding times after gene silencing. Co-transfection and GST pull-down assays were used to identify interactions between RhBcl-2 and RhBax.

Results: The RT-qPCR assay revealed that RhBax gene transcription increased significantly during feeding at all tick developmental stages (engorged larvae, nymphs, and adult females). Transcriptional levels of RhBcl-2 and RhBax increased more significantly in the female salivary glands than in other tissues post engorgement. RhBcl-2 silencing significantly inhibited tick feeding. In contrast, RhBax interference had no effect on tick feeding. TUNEL staining showed that apoptosis levels were significantly reduced after interference with RhBcl-2 expression. Co-transfection and GST pull-down assays showed that RhBcl-2 and RhBax could interact but not combine in the absence of the BH3 domain.

Conclusions: This study identified the roles of RhBcl-2 and RhBax in tick salivary gland degeneration and finds that the BH3 domain is a key factor in their interactions.
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http://dx.doi.org/10.1186/s13071-021-04879-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336254PMC
August 2021

Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma.

Gut 2021 Aug 3. Epub 2021 Aug 3.

Institute of Digestive Disease and The Department of Medicine and Therapeutics,State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences,CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China SAR

Objective: Altered metabolites are important for the tumourigenicity of hepatocellular carcinoma (HCC). We performed integrative metabolomics analysis of the metabolites changes in portal venous blood and in comparison with the metabolites changes in liver tissues and stool samples of HCC patients and healthy liver donors.

Design: Serum (portal and central vein), liver tissue (HCC tumour and adjacent non-tumour, normal liver) and stool samples were collected from 102 subjects (52 HCC patients and 50 healthy controls) in the discovery cohort; and 100 subjects (50 HCC patients and 50 healthy controls) in an independent validation cohort. Untargeted metabolomic profiling was performed using high-performance liquid chromatography-mass spectrometry. The function of candidate metabolites was validated in hepatocyte cell lines.

Results: Detailed metabolomic evaluation showed distinct clusters of metabolites in serum, liver tissue and stool samples from patients with HCC and control individuals (p<0.001). HCC patients had significantly higher levels of portal vein serum and HCC tissue metabolites of DL-3-phenyllactic acid, L-tryptophan, glycocholic acid and 1-methylnicotinamide than healthy controls, which were associated with impaired liver function and poor survival. On the other hand, HCC patients had lower levels of linoleic acid and phenol in portal vein and stool samples than healthy controls. Linoleic acid and phenol significantly inhibited HCC proliferation, inferring their anti-HCC function as protective metabolites.

Conclusions: The integrative metabolome analysis of serum, tissue and stool metabolites revealed unreported metabolic alterations in HCC patients. In portal vein, we identified elevated and depleted metabolites signifying that they might play a role in HCC development.
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http://dx.doi.org/10.1136/gutjnl-2021-325189DOI Listing
August 2021

Validating World Health Organization cardiovascular disease risk charts and optimizing risk assessment in China.

Lancet Reg Health West Pac 2021 Mar 5;8:100096. Epub 2021 Feb 5.

Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Background: World Health Organization (WHO) released region-specific cardiovascular disease (CVD) risk prediction charts recently, but the extent to which the charts can apply to Chinese population is unknown. We aimed to validate the WHO CVD risk charts for East Asia, and evaluate their practicability combining with China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) equations among Chinese adults.

Methods: The China-PAR cohort with 93,234 participants aged 40-80 years was followed up during 1992-2015, including 29,337 participants from three sub-cohorts with follow-up period of over 10 years. We validated the WHO CVD risk charts using the China-PAR cohort by assessment of the predicted number of events, C index, calibration χ², and calibration plots, further elaborated the concordance between the China-PAR equations and the WHO risk charts.

Findings: During an average follow-up of 13•64 years, 1849 incident CVD cases were identified from 29,337 participants. Both the laboratory-based and non-laboratory-based charts overestimated CVD events by 59% and 58% in men, and by 72% and 85% in women, respectively. However, 92% of participants identified as high risk by the China-PAR equations could be successfully detected by the laboratory-based charts at the cut-off point of 10%. We also observed that the non-laboratory-based charts demonstrated the poor performance for diabetic population, with high proportion of high-risk individuals (17% for men, 31% for women) would be missed.

Interpretation: Although the WHO CVD risk charts for East Asia apparently overestimated CVD risk among Chinese population, they could be pragmatic pre-selection tools, as potential supplement to the China-PAR equations. The widespread use of the WHO risk charts along with the China-PAR equations might facilitate the implementation of the risk-based CVD prevention in China.

Funding: Full funding sources are listed at the end of the paper (see Acknowledgments).
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http://dx.doi.org/10.1016/j.lanwpc.2021.100096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315380PMC
March 2021

Response to gefitinib/crizotinib combination in a pulmonary sarcomatoid carcinoma patient harboring concurrent EGFR mutation and MET amplification.

Clin Case Rep 2021 Jul 23;9(7):e04487. Epub 2021 Jul 23.

Department of Biotherapy Tianjin Medical University Cancer Institute and Hospital Tianjin China.

Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small cell lung cancer (NSCLC) with an extremely poor prognosis making it a therapeutic challenge. However, the development of genetic variation molecular diagnosis and targeted agents has brought the treatment of such malignancies to the precision era. Co-existing mutations of EGFR and MET have been reported in NSCLC, but rarely found in PSC. We herein present a rare case of a 74-year-old female patient diagnosed with PSC, carrying an activating mutation in exon 21 L858R of EGFR and a concurrent MET amplification prior to treatment. Combined application of gefitinib and crizotinib, inhibitors targeting EGFR and MET, respectively, was prescribed. The patient experienced a partial response and was stable for 9.7 months off therapy. The observation stresses the importance of genetic testing and paves the way for combined targeted strategies in PSC.
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http://dx.doi.org/10.1002/ccr3.4487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299264PMC
July 2021

Multidisciplinary cooperative mode led by infusion nurse specialists used to ensure the nursing quality of peripherally inserted central catheters in China: A 5-year retrospective study.

J Vasc Access 2021 Jul 21:11297298211033507. Epub 2021 Jul 21.

Chairperson of Infusion Therapy Board in Changhai Hospital, Naval Medical University & Associate Chairperson of Infusion Therapy Committee in Shanghai Nurses Association, Shanghai, China.

Objective: To analyze the effect of multidisciplinary cooperation mode (MCM) led by infusion nurse specialists (INSs) on peripherally inserted central catheters (PICC) catheterization and indwelling nursing quality.

Methods: Participants' demographic information, catheter types, catheterization approaches, puncture site, tip position, professional title of nurses, success rate of catheterization, consultation rate, detection rate of complications and outcome improvement rate of 6576 outpatients and hospitalized patients with PICC were analyzed retrospectively by a software named "questionnaire stars," in a large tertiary general hospital in Shanghai, from January 2015 to December 2019. SPSS 26.0 for Windows was used for data collection and description, Chi-square test were used for statistical analysis of enumeration data, and  < 0.05 was statistically significant.

Results: According to the catheter types' data, the use rate of three-way valve catheters decreased from 79.9% to 14.5%, while the use rate of three-way valve solo catheters increased from 12.7% to 51.6%, and the use rate of power injectable and open-ended catheters increased from 7.4% to 33.9%. According to the data of PICC catheterization method, conventional technology decreased significantly from 16.8% to 1.1%, modified Seldinger technique (MST) increased gradually from 26.1% to 51.3%, while ultrasound guided modified Seldinger technique (US and MST) decreased slightly from 57.2% to 47.6%. 7.5% catheter tip ends were malpositioned while nine indwelled PICCs were traced to have tip end malposition. The consultation rate was significantly higher than that before applying MCM led by INSs ( = 151.713,  < 0.05). After applying MCM led by INSs, the detection rate of complications was significantly higher than before ( = 5.499,  < 0.05), the rate of successful insertion at one time was significantly higher than before ( = 187.589,  < 0.05).

Conclusion: After the application of INSs-led MCM, progresses have been achieved. The nursing quality of patients' PICC was significantly improved than before.
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http://dx.doi.org/10.1177/11297298211033507DOI Listing
July 2021

Online Active Learning for Drifting Data Streams.

IEEE Trans Neural Netw Learn Syst 2021 Jul 21;PP. Epub 2021 Jul 21.

Classification methods for streaming data are not new, but very few current frameworks address all three of the most common problems with these tasks: concept drift, noise, and the exorbitant costs associated with labeling the unlabeled instances in data streams. Motivated by this gap in the field, we developed an active learning framework based on a dual-query strategy and Ebbinghaus's law of human memory cognition. Called CogDQS, the query strategy samples only the most representative instances for manual annotation based on local density and uncertainty, thus significantly reducing the cost of labeling. The policy for discerning drift from noise and replacing outdated instances with new concepts is based on the three criteria of the Ebbinghaus forgetting curve: recall, the fading period, and the memory strength. Simulations comparing CogDQS with baselines on six different data streams containing gradual drift or abrupt drift with and without noise show that our approach produces accurate, stable models with good generalization ability at minimal labeling, storage, and computation costs.
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http://dx.doi.org/10.1109/TNNLS.2021.3091681DOI Listing
July 2021
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