Publications by authors named "Jibril Mohammed"

18 Publications

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Pilot study on the effects of a culturally-sensitive and standard pain neuroscience education for Hausa-speaking patients with chronic neck pain.

Disabil Rehabil 2021 Oct 18:1-11. Epub 2021 Oct 18.

Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.

Purpose: To pilot feasibility and assess preliminary effectiveness of standard and culture-sensitive Pain Neuroscience Education (PNE) among Hausa-speaking patients with Chronic Neck Pain (CNP).

Methods: Adverts (online & clinic-based) were used to recruit Hausa-speaking patients with nonspecific CNP in Kano, Nigeria. Selected participants were randomized to culture-sensitive PNE (CSPNE), standard PNE (PNE), or control groups. Each group received bi-weekly sessions of exercise therapy for 6 weeks. Two sessions of PNE plus a home-based session were administered before exercise therapy in the PNE groups. Primary (pain-intensity and disability) and secondary (pain-knowledge, pain catastrophizing, and quality of life) outcomes were measured. The study was pre-registered (PACTR201902788269426).

Results: Fifty-three (out of 64) participants met the inclusion criteria. The majority of them were recruited through radio adverts (83%). Interventions were successfully administered and data collection was completed for the participants. About 15% and 17% drop-out rate was recorded before intervention (post-randomization) and during follow-up, respectively. Main results indicated that significant within-group improvements in disability and pain knowledge scores were found in favor of the PNE groups.

Conclusion: Culture-sensitive and standard PNE plus exercise therapy are feasible for Hausa patients with CNP, and current findings indicate support for reducing disability and increasing pain knowledge among them.Implications for rehabilitationBoth standard PNE and culture-sensitive PNE are feasible for administration as interventions for Hausa-speaking patients with CNP.Radio adverts may be necessary for patients recruitment in addition to specialists' referrals.Culturally sensitive PNE materials may be more desirable as an intervention option due to the low literacy level among the Hausa population.
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http://dx.doi.org/10.1080/09638288.2021.1988155DOI Listing
October 2021

Development of culturally sensitive pain neuroscience education materials for Hausa-speaking patients with chronic spinal pain: A modified Delphi study.

PLoS One 2021 2;16(7):e0253757. Epub 2021 Jul 2.

Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.

This study aimed to develop culturally sensitive pain neuroscience education (PNE) materials for Hausa speaking patients with chronic spinal pain (CSP). PNE is a program of teaching patients about pain that has gained considerable attention in research and is increasingly used during physical therapy for patients with chronic pain. It helps in decreasing pain, disability, fear-avoidance, pain catastrophization, movement restriction, and health care utilization among patients with chronic pain. However, existing PNE materials and their application are limited to few languages and cultural inclinations. Due to the variations in pain perceptions, beliefs, and related outcomes among different population groups, culture-sensitive PNE materials addressing these outcomes are warranted. A focus-group discussion comprising 4 experts was used to adapt and develop preliminary PNE materials. Thereafter, an internet-based 3-round modified Delphi-study involving 22 experts ensued. Experts' consensus/recommendations concerning the content were used in modifying the PNE materials. Consensus was predefined as ≥75% level of (dis)agreement. Eighteen experts completed the Delphi rounds. Nineteen, 18 and 18 experts participated in rounds 1, 2 and 3 respectively, representing 86%, 94% and 100% participation rate respectively. Consensus agreement was reached in every round and content of the materials, including drawings, examples, figures and metaphors were adapted following the experts' suggestions. We therefore concluded that, culture-sensitive PNE materials for Hausa speaking patients with CSP were successfully produced. The present study also provides a direction for further research whereby the effects of culturally-sensitive PNE materials can be piloted among Hausa speaking patients with CSP.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253757PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253446PMC
November 2021

Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD.

Eur Respir Rev 2021 Jun 23;30(160). Epub 2021 Jun 23.

Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Inhaled corticosteroids (ICSs) are indicated for the prevention of exacerbations in COPD; however, a significant proportion of patients at low risk of exacerbations are treated with ICSs. We conducted a systematic review including a diversity of types of study designs and safety outcomes with the objective of describing the risk of adverse effects associated with the long-term use of ICSs in patients with COPD.A total of 90 references corresponding to 83 studies were included, including 26 randomised clinical trials (RCTs), 33 cohort studies, and 24 nested case-control (NCC) studies. Analysis of 19 RCTs showed that exposure to ICSs for ≥1 year increased the risk of pneumonia by 41% (risk ratio 1.41, 95% CI 1.23-1.61). Additionally, cohort and NCC studies showed an association between ICSs and risk of tuberculosis and mycobacterial disease. There was a strong association between ICS use and local disorders such as oral candidiasis and dysphonia. The association between ICSs and the risk of diabetes and fractures was less clear and appeared significant only at high doses of ICSs.Since most patients with COPD are elderly and with frequent comorbidities, an adequate risk-benefit balance is crucial for the indication of ICSs.
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http://dx.doi.org/10.1183/16000617.0075-2021DOI Listing
June 2021

Assessment of the Presence of Resistance Genes Detected from the Environment and Selected Food Products in Benin.

J Environ Public Health 2021 4;2021:8420590. Epub 2021 Feb 4.

Laboratory of Monitoring and Environmental Studies, Ministry of the Living Environment and Sustainable Development, Benin.

Gram-negative bacilli can spread from the environment and through food products. This study aimed to characterize ESBL production and virulence genes from multidrug-resistant Gram-negative bacilli isolated from specimen collected from the environment, kitchen, and food products. A total of 130 samples were collected at local markets in seven different communities in Benin (Abomey-Calavi, Ouidah, Bohicon, Abomey, Parakou, Djougou, and Grand-Popo). Samples were cultured on McConkey and ChromID ESBL agar plates. The isolates were identified by the API 20E gallery. An antibiotic susceptibility test was carried out, and the detection of ESBL production and virulence-associated genes was carried out by Polymerase Chain Reaction (PCR). The data collected was coded and analyzed using GraphPad prism 7 software and Excel. The software R was used to calculate the correlation coefficient between the results of the detection of ESBL+ on agar and by the effect of the double synergy. The results showed that sixty-three (63) bacterial strains were isolated from the 130 samples, of which the dominant species was (10/63). The kitchen samples were the most contaminated with 36.50%. More than 40% of the isolates were resistant to at least three different classes of antibiotics. Also, blaSHV gene was detected in 33.33% (21/63) of the isolates and in all isolates of (5/5%). 11.11% (7/63) of isolates were virulent with dominance of the H gene, especially with (83.33%). The kitchen samples showed a high prevalence of ESBL-producing strains with H gene. This raises the problem of non-compliance with hygiene rules in community cooking and food handling.
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http://dx.doi.org/10.1155/2021/8420590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878073PMC
November 2021

Views and experiences of discharged COVID-19 patients in Kano, Nigeria: a qualitative study.

Pan Afr Med J 2020 17;37(Suppl 1):38. Epub 2020 Nov 17.

Department of Physiotherapy, Faculty of Allied Health Sciences, Bayero University Kano, Kano, Nigeria.

Introduction: COVID-19 has spread globally, thereby contributing to substantial hospitalisation rates and morbidity. However, little or no information is available on the experiences of patients with COVID-19 in an African-setting. The study aimed to explore the experiences of patients with COVID-19.

Methods: semi-structured interviews were conducted via telephone with eleven individuals who were managed and discharged due to COVID-19. A descriptive phenomenological approach to qualitative research was employed and participants were mainly asked about their experiences before, during and after hospitalisation for COVID-19. Data were analysed using thematic analysis.

Results: patients' viewpoints were suggestive of community and secondary transmission of COIVD-19 in the study area. A few participants experienced severe symptoms. Most participants tend to resign their condition to fate; while some displayed unfounded conspiracy theories. Nevertheless, precautionary measures to prevent infection were largely observed. COVID-19 also negatively affected activities of daily living of the participants. Furthermore, the participants were generally satisfied with quality of care provided. However, areas of patients' education, isolation centre set-up and caregiver-patient interaction needed further improvements. Lastly, experience of fear and stigma during post-hospitalisation were common.

Conclusion: COVID-19 impacted negatively on the lives of the studied population. However, their experience during hospitalisation was generally positive.
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http://dx.doi.org/10.11604/pamj.supp.2020.37.38.26609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796840PMC
February 2021

Effectiveness of Hands-Off Therapy in the Management of Primary Headache: A Systematic Review and Meta-Analysis.

Eval Health Prof 2021 Jan 7:163278720983408. Epub 2021 Jan 7.

Department of Rehabilitation Sciences, 26656Ghent University, Belgium.

A number of hands-off therapies have been widely reported and are used in the management of headache. This systematic review and meta-analysis aimed to assess evidence supporting these therapies on selected headache outcomes. A systematic literature search for randomized clinical trials reporting on the effects of hands-off therapies for headache was performed in two electronic databases; PubMed and Web of Science (PROSPERO: CRD42018093559). Risk of bias was assessed using the Cochrane risk of bias tool. Meta-analysis was performed using Review Manager v5.4. Thirty-five studies, including 3,403 patients with migraine, tension-type or chronic headaches were included in the review. Methodological quality of the studies ranged from poor to good. Result-synthesis revealed moderate evidence for aerobic exercises, relaxation training and pain education for reducing pain intensity and disability. Other hands-off interventions were either weak or limited in evidence. Meta-analysis of 22 studies indicated that the effect of hands-off therapies significantly differed from one another for pain intensity, disability and quality of life (p < 0.05). Relaxation training, aerobic and active/stretching exercises had significant effect on pain intensity and disability (p < 0.05). To conclude, few hands-off therapies were effective on selected headache outcomes. Evidence to support other hands-off therapies is limited by paucity of studies.
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http://dx.doi.org/10.1177/0163278720983408DOI Listing
January 2021

Mobile phone reminders for enhancing uptake, completeness and timeliness of routine childhood immunization in low and middle income countries: A systematic review and meta-analysis.

Vaccine 2021 01 1;39(2):209-221. Epub 2020 Dec 1.

Department of Physiotherapy, Bayero University, Kano, Kano State, Nigeria.

Immunization remains one of the most effective public health interventions offering protection for children from vaccine preventable diseases. However, many children living in low- and- middle income countries do not get adequate immunization due to several factors. Mobile phone reminder interventions have shown great potential in enhancing a number of immunization outcomes. However, the evidence supporting its use in these countries is vague. This systematic review was conducted to provide evidence for mobile phone reminder in enhancing immunization uptake, completeness and timeliness. This review was conducted in accordance to the PRISMA recommendations. Three online databases; PubMed, Cochrane Library and African Journals Online, were systematically searched for potentially relevant studies. Screening of records (titles/abstracts from and full-texts) was done using Covidence. Meta-analyses were conducted using the Cochrane Collaboration Review Manager (v5.4). The GRADEpro was used to evaluate the certainty of evidence/summary of findings. Eleven RCTs assessing immunization uptake, completeness and/or timeliness by means of SMS, phone calls or a combination of voice message and SMS were included in both quantitative and qualitative synthesis. Overall, the included studies were of moderate quality. Majority of the included studies indicated that mobile phone reminders were beneficial. Meta-analyses indicated that using mobile phone reminder interventions for the review outcomes was of variable effect with high level of heterogeneity. A combination of voice message and SMS has a greater effect followed by phone calls then SMS reminders for immunization completeness. The use of SMS for immunization uptake and timeliness were largely insignificant (p > 0.05). Furthermore, evidence to support the efficacy of mobile phone reminder from the GRADE synthesis was between low and moderate. Mobile phone reminders, particularly a combination of voice message + SMS and perhaps phone calls appears to be more effective in enhancing immunization outcomes. However, more studies are required in view of methodological inadequacies in existing studies.
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http://dx.doi.org/10.1016/j.vaccine.2020.11.043DOI Listing
January 2021

Physiotherapy management of COVID-19 in Africa: Ongoing efforts, challenges, and future directions.

Physiother Theory Pract 2020 08 29;36(8):871-872. Epub 2020 Jul 29.

Department of Physiotherapy, Faculty of Allied Health Sciences, Bayero University , Kano, Nigeria.

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http://dx.doi.org/10.1080/09593985.2020.1798163DOI Listing
August 2020

Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review.

Support Care Cancer 2019 Jan 25;27(1):69-86. Epub 2018 Sep 25.

Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, Belgium.

Purpose: To describe the impairments in physical fitness in individuals who were previously diagnosed and treated for childhood cancer.

Methods: Using the PRISMA-guidelines, a systematic search was performed in PubMed, Web of Science, and Embase using a combination of the following predefined keywords: "exercise capacity" OR "aerobic capacity" OR "fitness" OR "cardiorespiratory fitness" OR "cardiopulmonary fitness" OR "physical fitness" OR "exercise testing" OR "exercise tolerance" OR "exercise" OR "oxygen consumption" AND "leukemia" OR "childhood cancer" OR "childhood cancer survivors (CCS)". Studies that met our inclusion criteria were reviewed on methodological quality, while the Newcastle-Ottawa Scale was used for evidence synthesis.

Results: A total of 2644 articles were identified from the database search. After screening based on the eligibility (abstracts) and inclusion (full texts) criteria, 49 articles remained. Even though the risk-of-bias scores in the studies were generally low, yet the results from those with high-quality studies revealed that poor fitness levels were prevalent in individuals with acute lymphoblastic leukemia, brain tumor, and mixed cancer histories, compared to healthy controls.

Conclusions: A global glance at CCS shows poor levels of fitness that is continuous and life-long even after active cancer treatment has ended. Nevertheless, the results presented in this review were based on a limited number of high-quality studies suggesting the need to for additional clinical trials in the topic area.
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http://dx.doi.org/10.1007/s00520-018-4483-8DOI Listing
January 2019

Molecular Typing and Antimicrobial Susceptibility of Methicillin-Resistant Isolated from Bovine Milk in Tanzania.

Int J Microbiol 2018 12;2018:4287431. Epub 2018 Mar 12.

Department of Microbiology, Parasitology and Biotechnology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.

Methicillin-resistant (MRSA) in raw milk can be transmitted from animals to humans, and in Tanzania raw milk is sold in local markets and consumed as purchased. This study was performed to determine the molecular characteristics and antimicrobial susceptibility pattern of MRSA strains isolated from raw bovine milk sold at local markets in Tanzania. A total of 117 raw milk samples were cultured on Baird-Parker medium to isolate and PCR was used for amplification of gene for identification and the presence of gene for methicillin-resistant strains. Coagulase-negative (CN) were reconfirmed using tube coagulase, DNase, and API Staph tests. MRSA isolates were typed whereas antimicrobial susceptibility testing was performed by the disc diffusion method. Forty-six coagulase positives (CP) and two CN were identified. Most strains were resistant to penicillin (72%), and 3 isolates: 2 CN and 1 coagulase-negative Staphylococci (CNS), were phenotypically resistant to vancomycin, oxacillin, and cefoxitin and were confirmed to carry Resistance to clindamycin, trimethoprim-sulfamethoxazole, and tetracycline was 23.9%, 30.4%, and 41.3%, respectively. Twelve isolates exhibited multidrug resistance; however, only one positive strain among the three was typeable and belonged to type t2603. This study reports for the first time the presence of CN variant of MRSA, which was assigned the spa type t2603, and the presence of multidrug resistant isolates from bovine milk in Morogoro, Tanzania.
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http://dx.doi.org/10.1155/2018/4287431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867597PMC
March 2018

Antimicrobial resistance among clinically relevant bacterial isolates in Accra: a retrospective study.

BMC Res Notes 2018 Apr 25;11(1):254. Epub 2018 Apr 25.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg, Denmark.

Objective: The aim of this study was to determine the antimicrobial resistance pattern of bacterial isolates from different specimens at various hospitals and private diagnostic service laboratories in Ghana.

Results: A retrospective data of culture and sensitivity test results from 2016 were extracted from the microbiology record book of six laboratories in Accra, Ghana. The data included type of clinical specimen, sex of patient, name of bacterial isolate and antibiotic resistance profile. A total of 16.6% (n = 10,237) resistant isolates were obtained, however, the proportions of resistant isolates varied significantly between laboratories. High resistance towards tetracycline, ampicillin, cotrimoxazole and cephalosporins, but low towards amoxiclav and aminoglycosides, was observed. This study identified E. coli and Staphylococcus species as the major resistant bacteria from clinical specimen in Accra and the highest prevalence of the isolates was found in urine specimens in all six laboratories (69.1%, n = 204; 52.6%, n = 36; 52.3%, n = 350; 37.9%, n = 298; 53%, n = 219; 62.1%, n = 594) and in female patients (81.4, 50 and 69.5%). Regular surveillance and local susceptibility pattern analysis is extremely important in selecting the most appropriate and effective antibiotic for the treatment of bacterial infections.
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http://dx.doi.org/10.1186/s13104-018-3377-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918760PMC
April 2018

Low education and lack of spousal relationship are associated with dementia in older adults with diabetes mellitus in Nigeria.

Psychogeriatrics 2018 May 8;18(3):216-223. Epub 2018 Feb 8.

Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

Background: The relationship between dementia and type 2 diabetes mellitus (T2DM) in older adults is well established in the literature. However, there have been few studies on this relationship in older adults living in low- and middle-income countries, and most demographic projections predict that older adult population will increase substantially in these regions by 2050.

Methods: In this study, older adults with T2DM attending a tertiary health facility were examined and compared with community-dwelling older adults without T2DM. The participants were assessed using the Consortium to Establish Registry for Alzheimer's Disease, the Stick Design Test, the 30-item Geriatric Depression Scale, and the Instrumental Activities of Daily Living Scale. Additionally, all the participants had a physical examination, including assessment of glycated haemoglobin, fasting blood glucose, lipid profile, and HIV status. A consensus diagnosis of dementia was made based on the criteria for dementia in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and the International Classification for Diseases, 10th edition. The data were analyzed using SPSS version 20 for Windows.

Results: This study included 224 diabetic patients and 116 controls. A total of 27 diabetic patients (12.1%) had dementia, 19 of whom were women. Of the 27 diabetic patients with dementia, 25 patients (92.6%) had Alzheimer's disease and 2 patients (7.4%) had mixed dementia (vascular dementia and Alzheimer's disease). Only one person among the controls had Alzheimer's type dementia. Dementia in the diabetic patients was significantly associated with advancing age, female gender, education level, duration of diabetes, and absence of a spouse.

Conclusion: Dementia is common in older adults with T2DM in this low-resource setting, and the risk factors for dementia were similar to those reported in earlier studies in Western societies.
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http://dx.doi.org/10.1111/psyg.12309DOI Listing
May 2018

Cardiac Autonomic Function and Reactivity Tests in Physically Active Subjects with Moderately Severe COPD.

COPD 2018 02 5;15(1):51-59. Epub 2018 Jan 5.

a Department of Rehabilitation Sciences and Physiotherapy , Ghent University , Ghent , Belgium.

Patients with chronic obstructive pulmonary disease (COPD) show impairments in the autonomic nervous systems (ANS) function, which is responsible for cardiac autonomic regulation. This study assessed the autonomic function and cardio-vagal reactivity in conveniently sampled subjects with COPD participating in a pulmonary rehabilitation (PR) program. Twenty-six subjects with COPD and 22 age and gender matched control subjects were evaluated. R-R intervals were collected at rest in supine position. Thereafter, resting autonomic function parameters comprising linear and nonlinear analyses of heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated. Autonomic reactivity tests comprising deep breathing (DB), Valsalva maneuver (VM), and head up tilt (HUT) were also performed. The results of this study indicated that resting autonomic function variables were generally reduced in COPD compared to controls. However, this difference was only statistically significant for a few HRV parameters: mean RR intervals, low frequency (LF), standard deviation of dispersion of points perpendicular to the line-of-identity (SD1), and approximate entropy (ApEn) (p < 0.05). The results also indicated that all cardio-vagal indices following the autonomic reactivity tests were comparable between COPD and controls (p > 0.05). It was concluded that subtle autonomic impairments exists in physically active COPD patients, and these autonomic function deficits were mainly recognized by resting HRV indices and not autonomic reactivity tests.
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http://dx.doi.org/10.1080/15412555.2017.1412414DOI Listing
February 2018

Evidence for aerobic exercise training on the autonomic function in patients with chronic obstructive pulmonary disease (COPD): a systematic review.

Physiotherapy 2018 03 22;104(1):36-45. Epub 2017 Jul 22.

Department of Rehabilitation Sciences Physiotherapy, Ghent University, Ghent, Belgium.

Objective: To assess evidence for the effectiveness of aerobic exercise training (AET) on the autonomic function (AF) outcomes in patients with chronic obstructive pulmonary disease (COPD).

Data Sources: Online databases of PubMed, CINAHL and Web of Science were systematically searched for all years till 26th of January, 2017.

Study Selection: Clinical studies assessing any measure of AF following exercise training in patients with COPD were included.

Data Extraction And Synthesis: Data were extracted from studies with high methodological quality for evidence synthesis. Rating of evidence quality was determined using the GRADE guidelines.

Results: The Majority of the included studies utilized continuous exercise training mode with a vigorous level of intensity. Each exercise training session lasted between 30 to 40minutes, and the frequency of intervention was ≥3 times/week. Evidence synthesis of studies with high methodological quality revealed that a high quality evidence level supported a significant increase for time-domain heart rate variability (HRV) analyses and the heart rate recovery (HRR) following AET. The review also found that frequency domain HRV analyses were not significantly affected by AET. The evidence to support the effect of exercise training on baroreceptor sensitivity (BRS) in patients with COPD is very low.

Conclusion: Aerobic exercise training demonstrated beneficial but limited effects on the AF in COPD. Presently, it is not clear whether these effects are sustained in the long term. Only a limited number of RCTs were available indicating a significant gap in the literature.
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http://dx.doi.org/10.1016/j.physio.2017.07.004DOI Listing
March 2018

Autonomic symptoms in patients with moderate and severe chronic obstructive pulmonary disease.

Acta Clin Belg 2018 Jun 22;73(3):182-190. Epub 2017 Sep 22.

a Department of Rehabilitation Sciences and Physiotherapy , Ghent University , Ghent , Belgium.

Objectives: A synoptic description of the autonomic symptoms profile (ASP) of patients with COPD is not available. Therefore, we aimed to provide an overview of autonomic symptoms and its associates in COPD.

Methods: We evaluated 89 subjects with COPD (65 ± 7.3 years; 66 males; GOLD II-IV) with an equal number of age- and sex-matched control subjects by means of the composite autonomic symptom score (COMPASS 31) questionnaire, which assesses autonomic symptoms across six domains (orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, urinary and pupillomotor). Lung function, medication use and health status variables (quality of life: physical/mental component summary [PCS/MCS], fatigue, anxiety, depression and dyspnea levels) were also assessed.

Results: Compared to controls, all subjects with COPD reported significantly higher orthostatic intolerance, secretomotor and total autonomic symptom scores (p < .05). Additionally, subjects with moderate COPD also reported significantly higher scores for vasomotor, gastrointestinal, urinary and pupillomotor symptoms compared to controls (p < .05). Nevertheless, these symptoms were comparable between the moderate and severe COPD subgroups (p > .05). The COPD subjects had poorer health status compared to controls as exhibited by significantly higher scores for depression, anxiety, fatigue and dyspnea, and lower scores values for PCS and MCS scores (p < .05). These health status variables were mildly associated with autonomic symptoms (0.214 ≤ r ≥ 0.421; p < .05), but not with demographic and lung function (p > .05). The MCS was the only significant predictor of total autonomic symptoms score in COPD (p = 0.001; β = -0.430).

Conclusion: Autonomic symptoms are present in all domains of the COMPASS-31 in COPD, irrespective of disease severity and demographic variables. Autonomic symptoms in COPD were mainly influenced by poor mental health.
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http://dx.doi.org/10.1080/17843286.2017.1379255DOI Listing
June 2018

Effect of respiratory rehabilitation techniques on the autonomic function in patients with chronic obstructive pulmonary disease: A systematic review.

Chron Respir Dis 2017 Aug 15;14(3):217-230. Epub 2016 Dec 15.

1 Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Belgium.

Patients with chronic obstructive pulmonary disease (COPD) show several extrapulmonary abnormalities such as impairment in the autonomic function (AF). Similarly, the use of respiratory training techniques such as controlled breathing techniques, noninvasive mechanical ventilation (NIMV), and oxygen supplementation for AF modulation in patients with COPD is popular in existing literature. However, the evidence to support their use is nonexistent. A systematic search of studies reporting on the effect of controlled breathing techniques, NIMV, and/or oxygen supplementation techniques on AF outcome parameters was conducted in three online databases: PubMed, Embase, and Web of Science. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement, relevant studies were retained and qualitatively analyzed for evidence synthesis. The methodological quality in these studies was evaluated using the evidence based guideline development (EBRO) checklists per designs provided by the Dutch Cochrane Centre. Eighteen studies met the inclusion criteria of the review and were included and discussed. The evidence synthesis revealed that a strong and moderate level evidence supported oxygen supplementation and slow breathing techniques, respectively, in significantly enhancing the baroreceptor sensitivity (BRS) values in patients with COPD. The effect of the examined techniques on the heart rate variability and muscle sympathetic nerve activity was of a limited or inconsistent evidence. The findings from this review suggest that oxygen supplementation and controlled breathing techniques have profound positive influence on the BRS in patients with COPD. However, it is not fully clear whether these influence translates to any therapeutic benefit on the general AF of patients with COPD in the long term.
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http://dx.doi.org/10.1177/1479972316680844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720228PMC
August 2017

Evidence for Autonomic Function and Its Influencing Factors in Subjects With COPD: A Systematic Review.

Respir Care 2015 Dec 20;60(12):1841-51. Epub 2015 Oct 20.

Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, Belgium.

Cardiovascular autonomic neuropathy is one of the factors implicated in the high morbidity and mortality rate in patients with COPD. Thus, several studies and nonsystematic reviews have increasingly reported autonomic function impairment in these subjects. For a better understanding, this systematic review was performed to evaluate not only the evidence for autonomic function impairment, but also factors influencing it. The results of the studies reviewed showed a strong level of evidence to support the impairment of heart rate variability in the time domain. A similar evidence level was also found to support impairment in baroreceptor sensitivity and muscle sympathetic nerve activity. Furthermore, this review identified physical activity level, muscle function, and circadian rhythm as the major influencing factors (strong evidence) of autonomic function in subjects with COPD. However, no definite conclusion could be reached for factors such as dyspnea, anxiety, body composition, pulmonary function, age, breathing frequency, ventilatory effort, quality of life, and disease severity due to limited, conflicting, or lack of existing evidence. The results of this review highlight relevant clinical messages for clinicians and other health-care providers regarding the role autonomic function can play as an important physiological marker for prognostication and stratification. Hence, autonomic function outcomes should be identified and considered during management of patients with COPD. Moreover, this review can serve as basis for future research aimed at assessing the interventions for autonomic function abnormalities in these patients.
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http://dx.doi.org/10.4187/respcare.04174DOI Listing
December 2015

Anthropometry and cardiovascular disease risk factors among retirees and non-retirees in Ile-Ife, Nigeria: A comparative study.

Niger Med J 2013 May;54(3):160-4

Department of Physiotherapy, Ladoke Akintola University of Technology Teaching Hospital, Osun State, Nigeria.

Background: Increasing affluence in low-income countries has been associated with lifestyle-related conditions, which may afford some people the opportunity to retire from gainful employment. This study examined the relationship between selected anthropometric variables and cardiovascular disease risk factors among age-matched retirees and non-retirees in Ile-Ife, Nigeria.

Materials And Methods: Self-reported healthy adults (104 retirees and 99 age-matched non-retirees) were purposively recruited. Weight, height, waist circumference, systolic blood pressure and diastolic blood pressure were measured with standard equipment and procedures. An established questionnaire was used to classify the subjects into high, medium and low cardiovascular disease risk categories. The data were analysed with basic description and inferential statistics.

Results: Mean ages for the retirees and non-retirees were 64.8 ± 7.0 years and 63.8 ± 4.5 years, respectively. The mean systolic blood pressure, diastolic blood pressure and waist circumference were higher for the retirees than for the non-retirees (all P < 0.01) as were the mean cardiovascular disease risk factors scores (P < 0.01).

Conclusion: The study concludes that retirees have a higher risk for cardiovascular disease than non-retirees and weight and Body Mass Index are the major determinants. Studies are needed to explain the differences in body composition indices and cardiovascular disease risk factors between retirees and age-matched non-retirees.
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http://dx.doi.org/10.4103/0300-1652.114568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719241PMC
May 2013
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