Jiazhi Hu

Jiazhi Hu

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Jiazhi Hu

Jiazhi Hu

Publications by authors named "Jiazhi Hu"

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18Publications

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REV7 is required for processing AID initiated DNA lesions in activated B cells.

Nat Commun 2020 Jun 4;11(1):2812. Epub 2020 Jun 4.

State Key Laboratory of Molecular Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41467-020-16632-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272641PMC
June 2020

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.

Cell Res 2020 Apr 30. Epub 2020 Apr 30.

State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41422-020-0328-3DOI Listing
April 2020

The Deubiquitinase USP38 Promotes NHEJ Repair through Regulation of HDAC1 Activity and Regulates Cancer Cell Response to Genotoxic Insults.

Cancer Res 2020 Feb 24;80(4):719-731. Epub 2019 Dec 24.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2149DOI Listing
February 2020

Improving Ionic Conductivity with Bimodal-Sized LiLaZrO Fillers for Composite Polymer Electrolytes.

ACS Appl Mater Interfaces 2019 Apr 20;11(13):12467-12475. Epub 2019 Mar 20.

Department of Chemical and Materials Engineering , University of Kentucky , Lexington 40506 , United States.

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http://dx.doi.org/10.1021/acsami.8b21770DOI Listing
April 2019

Optimizing genome editing strategy by primer-extension-mediated sequencing.

Cell Discov 2019 26;5:18. Epub 2019 Mar 26.

1The MOE Key Laboratory of Cell Proliferation and Differentiation, Genome Editing Research Center, School of Life Sciences, Peking University, Beijing, 100871 China.

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http://dx.doi.org/10.1038/s41421-019-0088-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434046PMC
March 2019

CRISPR/Cas9-mediated targeted chromosome elimination.

Genome Biol 2017 11 24;18(1):224. Epub 2017 Nov 24.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s13059-017-1354-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701507PMC
November 2017

Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast .

J Biol Chem 2017 04 21;292(15):6056-6075. Epub 2017 Feb 21.

From the Peking-Tsinghua Center for Life Sciences, National Laboratory of Protein and Plant Gene Research, College of Life Sciences,

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http://dx.doi.org/10.1074/jbc.M116.767806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391739PMC
April 2017

Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells.

J Biol Chem 2017 03 3;292(12):4777-4788. Epub 2017 Feb 3.

From the Peking-Tsinghua Center for Life Sciences, The National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China

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http://dx.doi.org/10.1074/jbc.M116.758599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377794PMC
March 2017

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.

J Exp Med 2016 08 15;213(9):1921-36. Epub 2016 Aug 15.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1084/jem.20160670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995090PMC
August 2016

Highly sensitive and unbiased approach for elucidating antibody repertoires.

Proc Natl Acad Sci U S A 2016 07 27;113(28):7846-51. Epub 2016 Jun 27.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1608649113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948367PMC
July 2016

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing.

Nat Protoc 2016 May 31;11(5):853-71. Epub 2016 Mar 31.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2016.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895203PMC
May 2016

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.

Cell 2015 Nov 22;163(4):947-59. Epub 2015 Oct 22.

Howard Hughes Medical Institute; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660266PMC
November 2015

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Nature 2015 Sep 26;525(7567):134-139. Epub 2015 Aug 26.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nature14970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592165PMC
September 2015

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

Nat Biotechnol 2015 Feb 15;33(2):179-86. Epub 2014 Dec 15.

1] Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Howard Hughes Medical Institute, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nbt.3101
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http://dx.doi.org/10.1038/nbt.3101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320661PMC
February 2015

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.

Cell 2014 Dec 4;159(7):1538-48. Epub 2014 Dec 4.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322776PMC
December 2014

Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.

Cancer Immunol Res 2014 Sep 9;2(9):857-66. Epub 2014 Jun 9.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital; and Department of Genetics, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156541PMC
September 2014

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10269-74. Epub 2014 Jun 30.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1410112111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104897PMC
July 2014

The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing.

Cell 2012 Jun;149(6):1221-32

The National Laboratory of Protein Engineering and Plant Genetic Engineering, The College of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1016/j.cell.2012.04.030DOI Listing
June 2012