Publications by authors named "Jiaxin Song"

31 Publications

Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction.

EBioMedicine 2021 Dec 24;74:103713. Epub 2021 Nov 24.

Shanghai Engineering Research Center of Organ Repair, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China. Electronic address:

Background: Exercise can protect myocardial infarction (MI) and downregulate cardiac Homeodomain-Interacting Protein Kinase 2 (HIPK2). However, the role of HIPK2 in MI is unclear.

Methods: HIPK2 mice and miR-222 rats, HIPK2 inhibitor (PKI1H) and adeno-associated virus serotype 9 (AAV9) carrying miR-222 were applied in the study. Animals were subjected to running, swimming, acute MI or post-MI remodeling. HIPK2 inhibition and P53 activator were used in neonatal rat cardiomyocytes (NRCMs) and human embryonic stem cell-derived cardiomyocytes (hESC-CMs) subjected to oxygen glucose deprivation/reperfusion (OGD/R). Serum miR-222 levels were analyzed in healthy people and MI patients that were survival or readmitted to the hospital and/or died.

Findings: Cardiac HIPK2 protein levels were reduced by exercise while increased in MI. In vitro, HIPK2 suppression by lentiviral vectors or inhibitor prevented apoptosis induced by OGD/R in NRCMs and hESC-CMs. HIPK2 inhibitor-treated mice and HIPK2 mice reduced infarct size after acute MI, and preserved cardiac function in MI remodeling. Mechanistically, protective effect against apoptosis by HIPK2 suppression was reversed by P53 activators. Furthermore, increasing levels of miR-222, targeting HIPK2, protected post-MI cardiac dysfunction, whereas cardiac dysfunction post-MI was aggravated in miR-222 rats. Moreover, serum miR-222 levels were significantly reduced in MI patients, as well as in MI patients that were readmitted to the hospital and/or died compared to those not.

Interpretation: Exercise-induced HIPK2 suppression attenuates cardiomyocytes apoptosis and protects MI by decreasing P-P53. Inhibition of HIPK2 represents a potential novel therapeutic intervention for MI.

Funding: This work was supported by the grants from National Key Research and Development Project (2018YFE0113500 to JJ Xiao), National Natural Science Foundation of China (82020108002, 81722008, and 81911540486 to JJ Xiao, 81400647 to MJ Xu, 81800265 to YJ Liang), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042 to JJ Xiao), the grant from Science and Technology Commission of Shanghai Municipality (18410722200 and 17010500100 to JJ Xiao), the "Dawn" Program of Shanghai Education Commission (19SG34 to JJ Xiao), Shanghai Sailing Program (21YF1413200 to QL Zhou). JS is supported by Horizon2020 ERC-2016-COG EVICARE (725229).
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http://dx.doi.org/10.1016/j.ebiom.2021.103713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626841PMC
December 2021

Comparisons of kilowatt Yb-Raman fiber amplifiers employing a superfluorescent fiber source and fiber oscillator.

Opt Express 2021 Jul;29(15):22966-22972

In this paper, we demonstrate experimental investigations on kilowatt-level Yb-Raman fiber amplifiers (YRFAs) employing a superfluorescent fiber source (SFS) or a multi-longitudinal mode fiber oscillator (OSC) as the Raman-pump laser. Through comparing the output properties of the two YRFAs, the experimental results reveal that the YRFA employing the SFS is superior to the YRFA employing the OSC in the performances of power scalability and narrow-linewidth operation. Meanwhile, about 1.16 kW Raman-signal laser at 1120 nm is obtained through the YRFA employing the SFS as the Raman-pump laser. Overall, the presentation could provide an effective solution for the design of high-power narrow linewidth YRFAs.
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http://dx.doi.org/10.1364/OE.432887DOI Listing
July 2021

Temporally stable fiber amplifier pumped random distributed feedback Raman fiber laser with record output power.

Opt Lett 2021 Oct;46(19):5031-5034

In this Letter, we propose a scheme to use a temporally stable pump source in a high-power random distributed feedback Raman fiber laser (RRFL) with a half-open cavity. Different from conventional pump manners, the pump source is based on an Yb-doped fiber amplifier, seeded by a temporally stable phase-modulated single-frequency fiber laser for suppressing the spectral broadening and second-order Raman Stokes generation in the output laser. Using a piece of 50-m-long 20/400 µm passive fiber, the maximum output power of 1570 W was obtained with a pump power of 2025 W. The conversion efficiency with respect to the pump power was 77.5%. To the best of our knowledge, this is the highest output power ever reported in a RRFL to date. This work could provide a novel method for power scaling of RRFLs.
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http://dx.doi.org/10.1364/OL.438352DOI Listing
October 2021

Surface roughness effect on fatigue strength of aluminum alloy using revised stress field intensity approach.

Sci Rep 2021 Sep 29;11(1):19279. Epub 2021 Sep 29.

Northeastern University, Shenyang, 110819, People's Republic of China.

The fatigue strength of a component is known to highly depend on its surface quality, and it is thus necessary to develop a reliable and appropriate mathematical model for fatigue strength assessment that consider the effect of surface roughness. In this paper, different underlying physical mechanisms of the roughness effect at different regions of specimens were studied by fatigue testing of 7N01 aluminum alloy. For a quantitative analysis of the surface roughness effect, a revised stress field intensity approach for a fatigue strength assessment of microsized notches was proposed as a theoretical support. In the new model, a new form of weight function was built to adapt the characteristics of microsized notches. In addition, the effect of the field radius was fundamentally weakened on solution of the stress field intensity and the difficulty of fatigue failure region definition in the traditional method was overcome correspondingly in the proposed model, which made the calculated field strength accurate and objective. Finally, to demonstrate the validity of the revised approach quantitatively, specimens with conventionally sized notches were subjected to stress field intensity calculations. The results showed that the revised approach has satisfactory accuracy compared with the other two traditional approaches from the perspective of quantitative analysis.
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http://dx.doi.org/10.1038/s41598-021-98858-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481500PMC
September 2021

Physiological Characteristics and Comparative Secretome Analysis of Grown on Glucose, Rice Straw, Sawdust, Wheat Grain, and MIX Substrates.

Front Microbiol 2021 25;12:636344. Epub 2021 May 25.

Institute of Vegetable, Wuhan Academy of Agricultural Sciences, Wuhan, China.

Morels ( sp.) are economically important edible macro-fungi, which can grow on various synthetic or semi-synthetic media. However, the complex nutritional metabolism and requirements of these fungi remain ill-defined. This study, based on the plant biomass commonly used in the artificial cultivation of morels, assessed and compared the growth characteristics and extracellular enzymes of cultivated on glucose, rice straw, sawdust, wheat grain, and a mixture of equal proportions of the three latter plant substrates (MIX). could grow on all five tested media but displayed significant variations in mycelial growth rate, biomass, and sclerotium yield on the different media. The most suitable medium for was wheat and wheat-containing medium, followed by glucose, while rice straw and sawdust were the least suitable. A total of 268 secretory proteins were identified by liquid chromatography coupled with tandem mass spectrometry detection. Functional classification and label-free comparative analysis of these proteins revealed that carbohydrate-active enzyme (CAZYme) proteins were the predominant component of the secretome of , followed by protease, peptidase, and other proteins. The abundances of CAZYme proteins differed among the tested media, ranging from 64% on glucose to 88% on rice straw. The CAZYme classes of glycoside hydrolases and carbohydrate-binding module were enriched in the five secretomes. Furthermore, the enzyme activities of CMCase, lignase, amylase, xylase, pNPCase, and pNPGase were detected during the continuous culture of in MIX medium, and the relative expression of the corresponding genes were detected by quantitative real-time PCR. The combined data of growth potential, secretome, extracellular enzyme activity, and gene expression on different substrates inferred that was weak in lignocellulose degradation but a good starch decomposer. Specifically, in terms of the degradation of cellulose, the ability to degrade cellulose into oligosaccharides was weaker compared with further degradation into monosaccharides, and this might be the speed-limiting step of cellulose utilization in . In addition, had a strong ability to decompose various hemicellulose glycosidic bonds, especially α- and β-galactosidase. Only a very few lignin-degradation-related proteins were detected, and these were in low abundance, consistent with the presence of weak lignin degradation ability. Furthermore, the presence of lipase and chitinase implied that was capable of decomposition of its own mycelia . The study provides key data that facilitates a further understanding of the complex nutritional metabolism of .
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http://dx.doi.org/10.3389/fmicb.2021.636344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185036PMC
May 2021

2  kW narrow-linewidth Yb-Raman fiber amplifier.

Opt Lett 2021 May;46(10):2404-2407

In this Letter, we report a high-power narrow-linewidth Yb-Raman fiber amplifier with a high second-order Raman threshold and high intensity stability. By employing two temporally stable seed lasers, over 2 kW output power at 1120 nm is achieved at a pump power of 2.6 kW with an optical-to-optical efficiency of 76.3%. The 3 dB linewidth of the 1120 nm Raman-signal laser varies slightly from 0.41 nm to 0.53 nm, and the power ratio of the second-order Raman Stokes light is only about ${-}{46.3}\;{\rm{dB}}$ at the output power of 2 kW. The results further confirm that the technique of employing temporally stable seed lasers is superior to the power scaling of narrow-linewidth Yb-Raman fiber amplifiers. To the best of our knowledge, it is the first demonstration of an over 2 kW narrow-linewidth fiber laser operating at 1120 nm.
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http://dx.doi.org/10.1364/OL.425714DOI Listing
May 2021

High power tunable multiwavelength random fiber laser at 1.3 μm waveband.

Opt Express 2021 Feb;29(4):5516-5524

Multiwavelength fiber lasers, especially those operating at optical communication wavebands such as 1.3 μm and 1.5 μm wavebands, have huge demands in wavelength division multiplexing communications. In the past decade, multiwavelength fiber lasers operating at 1.5 μm waveband have been widely reported. Nevertheless, 1.3 μm waveband multiwavelength fiber laser is rarely studied due to the lack of proper gain mechanism. Random fiber laser (RFL), owing to its good temporal stability and flexible wavelength tunability, is a great candidate for multiwavelength generation. Here, we reported high power multiwavelength generation at 1.3 μm waveband in RFL for the first time. At first, we employed a section of 10 km G655C fiber to provide Raman gains, as a result of which, 1.07 W multiwavelength generation at 1.3 μm waveband with an optical to signal noise ratio of ∼33 dB is demonstrated. By tuning the pump wavelength from 1055 nm to 1070 nm, tunable multiwavelength output covering the range of 1300-1330 nm can be achieved. Furtherly, we realized 4.67 W multiwavelength generation at 1.3 μm waveband by shortening the fiber length to 4 km. To the best of our knowledge, this is the highest output power ever reported for multiwavelength fiber lasers.
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http://dx.doi.org/10.1364/OE.412224DOI Listing
February 2021

Compact and low-cost superfluorescent fiber source assisted narrow linewidth Yb-Raman fiber amplifier.

Appl Opt 2021 Feb;60(6):1484-1488

Recent work has shown that temporally stable optical sources are required in a narrow linewidth Yb-Raman fiber amplifier to suppress the spectral broadening phenomenon. Superfluorescent fiber sources (SFSs) with different spectral widths are used as the Raman-pumped lasers in a 200-watt level narrow linewidth Yb-Raman fiber amplifier for the first time to the best of our knowledge. The experimental results reveal that the spectral broadening phenomenon could be well controlled by using the broadband SFS. Therefore, the narrow linewidth operation could be well maintained during the power scaling process. Moreover, the suppression of the spectral broadening phenomenon would deteriorate when the spectral width of the SFS decreases. This work could provide a compact, low-cost choice for the Raman-pumped laser in narrow linewidth Yb-Raman fiber amplifiers.
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http://dx.doi.org/10.1364/AO.413565DOI Listing
February 2021

Overexpression of MsSiR enhances alkali tolerance in alfalfa (Medicago sativa L.) by increasing the glutathione content.

Plant Physiol Biochem 2020 Sep 20;154:538-546. Epub 2020 Jul 20.

College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China. Electronic address:

The sulfite reductase gene in Medicago sativa L. (MsSiR) encodes sulfite reductase (SiR) and catalyses the conversion of sulfite to sulfate in the sulfite assimilation pathway. In this study, we investigated the role of MsSiR in alfalfa by generating transgenic alfalfa that ectopically expressed MsSiR under the control of the CaMV35S promoter. The differences in alkali tolerance between the MsSiR-overexpressing and wild-type (WT) plants were analyzed, and the MsSiR-overexpressing plants exhibited an improved phenotype under alkali stress. Compared to WT plants, these plants demonstrated improved antioxidant activity as well as decreased HO and O contents and increased glutathione reduced (GSH), Cysteine (Cys) and glutathione oxidized (GSSG) contents. MsSiR-overexpressing plants also exhibited high levels of adenosyl phosphosulfate reductases (APR), sulfite oxidase (SO) and MsSiR expression under alkali stress. It was speculated that MsSiR is involved in sulfur metabolism pathways, including the stabilization of sulfate and sulfite levels and the synthesis of GSH. These two processes achieve alkali tolerance by positively regulating the detoxification and antioxidant activities of alfalfa.
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http://dx.doi.org/10.1016/j.plaphy.2020.07.001DOI Listing
September 2020

Cascaded telecom fiber enabled high-order random fiber laser beyond zero-dispersion wavelength.

Opt Lett 2020 Aug;45(15):4180-4183

Four-wave mixing induced spectral broadening near the zero-dispersion wavelength (ZDW) of the fiber is a bottleneck factor that limits the further wavelength extending in cascaded random fiber lasers (RFLs). In this Letter, we successfully suppress the spectral broadening near the ZDW of the fiber in the cascaded RFL by simply combining two kinds of commercial telecom fibers with different ZDWs, G655C fiber with ZDW around 1.52 µm and G652D fiber with ZDW around 1.31 µm. As a result, an 8th order Stokes light component at 1721 nm with a maximum output power of 2.1 W and a spectral purity of 96.94% is realized in this telecom-fiber-based cascaded RFL. This work provides a reference of nonlinear effect management in fiber lasers as well as affords a cost-effective way with great potential of realizing high-power widely tunable fiber lasers.
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http://dx.doi.org/10.1364/OL.397361DOI Listing
August 2020

Power scaling of Raman fiber amplifier based on the optimization of temporal and spectral characteristics.

Opt Express 2020 Apr;28(8):12395-12404

We comprehensively study the effects of temporal and spectral optimization on single-mode Raman fiber amplifiers. Amplified spontaneous emission sources and ytterbium-doped fiber lasers are employed as seed or pump lasers for comparison, and passive fibers are utilized as gain media. The influences of various parameters of the laser on 2 order Raman threshold and maximum output power are investigated experimentally, including bandwidth, seed power, wavelength separation between pump and seed laser, and temporal stability. With the 190 m passive fiber, the output power increases from 99.5 W to 142.4 W, corresponding to 43.1% improvement through the optimization of seed laser power, pump wavelength and temporal performance of pump source in this amplifier, which has guidance on the establishment of high-power single-mode Raman fiber amplifiers.
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http://dx.doi.org/10.1364/OE.388240DOI Listing
April 2020

Broadband pumping enabled flat-amplitude multi-wavelength random Raman fiber laser.

Opt Lett 2020 Apr;45(7):1786-1789

A flat-amplitude multi-wavelength random Raman fiber laser with broad spectral coverage and a high optical signal-to-noise ratio (OSNR) is challenging and of great interest. In this Letter, we theoretically and experimentally proved that broadband pumping can help realize a broader, flat-amplitude multi-wavelength random Raman fiber laser. The influence of pump bandwidth, tunability of the spectral envelope, and channel spacing are investigated. As a result, with a 40 nm pump bandwidth, a spectral coverage of 1116-1125 nm with 19 laser lines and 31 dB OSNR is achieved, and the standard deviation in the peak intensities of the central nine lines is ${\sim}{1}.{1}\;{\rm dBm}$∼1.1dBm. This technique can also be applied to the multi-wavelength Raman (or random Raman) fiber lasers at other wavelengths and provide a reference for multi-wavelength applications in sensing, communication, and optical component testing.
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http://dx.doi.org/10.1364/OL.389071DOI Listing
April 2020

Dual-wavelength random distributed feedback fiber laser with wavelength, linewidth, and power ratio tunability.

Opt Express 2020 Mar;28(7):10515-10523

Owing to the special power distribution property, a random distributed feedback Raman fiber laser can achieve a high power spectrally flexible output with a low power spectrally tuning device. Here, an all-fiberized linearly polarized dual-wavelength random distributed feedback Raman laser with wavelength, linewidth, and power ratio tunability is demonstrated. By adopting two watt-level bandwidth adjustable optical filters, a spectrum-manipulable dual-wavelength output with nearly a 10 W output power is achieved. The wavelength separation can be tuned from 2.5 to 13 nm, and the 3 dB linewidth of the output can be doubled by increasing the bandwidth of the optical filter. The power ratio of each laser line can be tuned from 0 to nearly 100% with the help of two variable optical attenuators. A maximum output power of 9.46 W is realized, with a polarization extinction ratio up to 20.5 dB. The proposed dual-wavelength fiber laser can be employed as a pump source in frequency tunable, bandwidth adjustable terahertz microwave generation, and mid-infrared optical parametric oscillators.
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http://dx.doi.org/10.1364/OE.390796DOI Listing
March 2020

Sphingosine-1-phosphate alleviates irradiation-induced parotid injury in a miniature pig model.

Oral Dis 2020 Jul 10;26(5):920-929. Epub 2020 Mar 10.

Outpatient Department of Oral and Maxillofacial Surgery, School of Stomatology, Capital Medical University, Beijing, China.

Objectives: Our aim was to verify the alleviation effect of sphingosine-1-phosphate (S1P) in a miniature pig model.

Material And Methods: Thirty male miniature pigs were randomly separated into 10 groups in our experiment. We administered S1P through the parotid duct in a retrograde fashion 2 hr before irradiation (IR). The salivary flow rate and blood flow rate were tested 20 weeks after IR. The apoptotic level was checked at 12, 24 hr and 7 days post-IR.

Results: Twenty weeks after IR, the salivary flow rate of the IR-side parotid gland in IR + S1P group can be maintained at about 40% of the non-IR side, while only 20% was maintained in the IR group. The blood flow rate and microvascular density were significantly higher in the IR + S1P group than in the IR group. The apoptotic level and cleaved caspase-3 expression were downregulated in IR + S1P group, and the ratio of Bcl-2/Bax was increased. The blood flow rate and CD31 level were significantly restored at 12, 24 hr and 7 days post-IR.

Conclusion: Sphingosine-1-phosphate may partially alleviate IR-induced parotid dysfunction by decreasing apoptosis of microvascular endothelial cells and maintaining the blood flow rate.
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http://dx.doi.org/10.1111/odi.13302DOI Listing
July 2020

Tunable random Raman fiber laser at 1.7 µm region with high spectral purity.

Opt Express 2019 Sep;27(20):28800-28807

We demonstrate a tunable, high order cascaded random Raman fiber laser (RRFL) with high purity at 1.7 µm band by using a high power amplified spontaneous emission source (ASE) with both wavelength and linewidth tunability as pump source. The influence of the spectral bandwidth of the ASE source on the spectral purity of the output at 1.7 µm band is investigated. By adjusting the spectral bandwidth of the ASE source to the optimized 20 nm, output power >14 W with spectral purity up to 98.29% at 1715 nm is achieved. As far as we know, this is the highest spectral purity ever reported for a RRFL at 1.7 µm region. Furthermore, by adjusting the central wavelength of ASE source, the output of the RRFL can be tuned from 1695 to 1725 nm with >10 W output power. What's more, the spectral purity is above 92% over a tuning range from 1705 to 1725 nm.
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http://dx.doi.org/10.1364/OE.27.028800DOI Listing
September 2019

Phosphosilicate fiber-based dual-wavelength random fiber laser with flexible power proportion and high spectral purity.

Opt Express 2019 Aug;27(16):23095-23102

Phosphosilicate fiber has the inherent advantage of generating dual-wavelength output owing to the two Raman gain peaks at the frequency shifts of ∼13.2 THz (silica-related) and 39.9 THz (phosphorus-related), respectively. The frequency shift of 39.9 THz is often adopted to obtain long wavelength laser, while the control of Stokes light at 13.2 THz has attracted much attention currently. In this paper, a dual-wavelength random distributed feedback Raman fiber laser (RDFL) with over 100 nm wavelength interval and continuously tunable power proportion was presented based on phosphosilicate fiber for the first time. Through using the filtered amplified spontaneous emission (ASE) source as the pump source, the spectral purity of the Stokes light could be as high as 99.8%. By tuning two manual variable optical attenuators (VOAs), the power proportion of the silica-related Stokes light could range from ∼0% to 99.0%, and the maximum value is limited by the generation of second order Stokes light. Although the power handling capability of the VOA is merely 2 W, over 23 W total output power of the Stokes light was obtained thanks to the particular power distribution property of RDFL. This experiment demonstrates the potential to achieve a flexible high-power and high-spectral purity dual-wavelength RDFL output.
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http://dx.doi.org/10.1364/OE.27.023095DOI Listing
August 2019

Role of microtubule-associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's disease.

Aging (Albany NY) 2019 07;11(13):4597-4610

Biochemistry and Molecular Biology Department of College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.

Aberrant glycosylation of proteins has major implications for human diseases. To determine whether protein glycosylation contributes to the pathogenesis of Parkinson's disease (PD), a mouse model of PD was established by injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Induction of PD-like features was verified by assessing motor impairment and confirming reductions in biological markers, including dopamine, 5-hydroxytryptamine and tyrosine hydroxylase, as well as the aggregation of α-synuclein. Altered glycosylation was detected using biotinylated agaracus bisporus lectin, which specifically binds exposed Gal-(β-1,3)-GalNAc linked to glycoproteins. Subsequent lectin affinity chromatography coupled with mass spectrometry revealed enhanced glycosylation of microtubule-associated protein 6 (MAP6) in PD mice as compared to healthy controls. In situ dual co-immunofluorescence analysis and immunoblotting confirmed that MAP6 is glycosylated with Gal-(β-1,3)-GalNAc oligosaccharides, which in turn alters the distribution and structure of MAP6 complexes within neurons. This is the first study to described MAP6 as a glycoprotein containing Gal-(β-1,3)-GalNAc oligosaccharides and to show that hyperglycosylation of MAP6 is strongly associated with the pathogenesis of PD. These findings provide potentially valuable information for developing new therapeutic targets for the treatment of PD as well as reliably prognostic biomarkers.
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http://dx.doi.org/10.18632/aging.102072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660046PMC
July 2019

All-fiberized transverse mode-switching method based on temperature control.

Appl Opt 2019 May;58(14):3696-3702

In this paper, an all-fiberized transverse mode-switching method was proposed based on temperature control of few-mode (FM) fiber Bragg gratings (FBGs). Two types of fibers were selected to fabricate the FBG pair in order to match the reflection peaks of the desired mode. The temperature-dependence property of the FM FBGs has been utilized to tune the reflection spectra. Through temperature control, 20 W level output power was obtained when the output laser was switched between the mode and the mode in both an all-fiberized ytterbium-doped laser and a Raman laser, which is increased by ∼2 orders of magnitude compared with previous demonstrations (almost less than 100 mW).
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http://dx.doi.org/10.1364/AO.58.003696DOI Listing
May 2019

A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study.

BMC Endocr Disord 2018 Oct 19;18(1):73. Epub 2018 Oct 19.

Department of Epidemiology, Dalian Medical University, Lvshun West 9, Dalian, 116044, China.

Background: The present study aims to improve the M-stage classification of pancreatic neuroendocrine neoplasms (pNENs).

Methods: Two thousand six hundred sixty six pNENs were extracted from the Surveillance, Epidemiology, and End Results database to explore the metastatic patterns of pNENs. Metastatic patterns were categorized as single, two, or multiple (three or more) distant organ metastasis. The mean overall survival and hazard rate of different metastatic patterns were calculated by Kaplan-Meier and Cox proportional hazards models, respectively. The discriminatory capability of the modified M-stage classification was evaluated by Harrell's concordance index.

Results: The overall survival time significantly decreased with an increasing number of metastatic organs. In addition, pNENs with only liver metastasis had better prognosis when compared to other metastatic patterns. Thus, we modified the M-stage classification (mM-stage) as follows: mM-stage, tumor without metastasis; mM-stage, tumor only metastasized to liver; mM-stage, tumor metastasized to other single distant organ (lung, bone, or brain) or two distant organs; mM-stage, tumor metastasized to three or more distant organs. Harrell's concordance index showed that the modified M-stage classification had superior discriminatory capability than both the American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) M-stage classifications.

Conclusions: The modified M-stage classification is superior to both AJCC and ENETS M-stage classifications in the prognosis of pNENs. In the future, individualized treatment and follow-up programs should be explored for patients with distinct metastatic patterns.
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http://dx.doi.org/10.1186/s12902-018-0301-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194708PMC
October 2018

Interface self-assembly preparation of multi-element doped carbon nanobowls with high electrocatalysis activity for oxygen reduction reaction.

J Colloid Interface Sci 2019 Jan 31;533:569-577. Epub 2018 Aug 31.

Key Laboratory of Applied Surface and Colloid Chemistry (MOE), Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an 710119, PR China.

Developing an efficient, stable and low cost oxygen reduction reaction electrocatalyst is desirable for fuel cells and metal-air batteries. Here, we have successfully prepared multi-element doped carbon nanobowls by simply mixing the porous carbon nanobowls and sulfur doped graphitic carbon nitride quantum dots in FeCl solution and subsequent high temperature treatment processes. Compared with the commercial Pt/C electrocatalyst, the multi-element doped carbon nanobowls display a comparable half-wave potential of 0.82 V, much larger limiting diffusion current density (0.4-0.8 V), better methanol-tolerance and higher long-term stability for the oxygen reduction reaction in alkaline media. The robust three-dimensional porous structure of carbon nanobowls and multiple active centers derived from Fe, N, S and O co-doping are responsible for the excellent performance. This work suggests that such multi-element doped carbon nanobowls can be a promising alternative for Pt-based catalysts in fuel cells.
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http://dx.doi.org/10.1016/j.jcis.2018.08.103DOI Listing
January 2019

Power scalability of linearly polarized random fiber laser through polarization-rotation-based Raman gain manipulation.

Opt Express 2018 Sep;26(18):22894-22903

Random fiber laser based on Raman gain and random distributed feedback has drawn great attention in recent years. One of the most widely-studied fields is to improve the optical efficiency and the output power. However, the power scaling of a random fiber laser is instinctively restricted by the high order Stokes generation. In this manuscript, we propose a simple yet effective method, which employs a homemade all-fiber Lyot filter to manipulate the polarization dependent Raman gain, thus increasing the threshold of the 2nd-order Stokes wave and enhancing the maximum output power of the linearly polarized random fiber laser. Through reliable theoretical analysis, we optimize the design of the wavelength dependent Lyot filter. Moreover, the performance of the filter and the power scaling capability of the linearly polarized random fiber laser are investigated in detail. A proof-of-principle experiment is carried out by inserting the homemade Lyot filter into a half-opened random fiber laser. The experimental results indicate that the 2nd-order Stokes wave can be effectively suppressed, and the maximum output power of the 1st-order Stokes wave is significantly increased with a range of ~50% (from 43.6 to 63.2 W).
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http://dx.doi.org/10.1364/OE.26.022894DOI Listing
September 2018

A novel high-power all-fiberized flexible spectral filter for high power linearly-polarized Raman fiber laser.

Sci Rep 2018 Jul 19;8(1):10942. Epub 2018 Jul 19.

College of Advanced Interdisciplinary Studies, National University of Defense Technology, Changsha, 410073, China.

Power scaling of linearly polarized Raman fiber laser (LPRFL), which has wide application potentials, is mainly limited by the generation of high-order Stokes light. In this paper, we propose a novel flexible spectral filter with all-fiberized configuration and high-power handling. Combining with the polarization-dependence of Raman gain, the filter could be used to efficiently suppress high-order Stokes light in LPRFL and thus help further power scaling. The filter is fabricated by two 45° cross-splice of three pieces of polarization maintaining (PM) passive fibers. The bandwidth and central wavelength of transmission spectrum of the spectral filter could be flexibly tuned through changing the length and temperature of the cross-spliced fiber. The insertion loss of the filter fabricated in the lab is measured to be as low as 0.07 dB. The filter is employed in a LPRFL, and the maximum output power of the LPRFL is increased by 48.7%.
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http://dx.doi.org/10.1038/s41598-018-28686-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053399PMC
July 2018

Surfactant-Free Microemulsions of 1-Butyl-3-methylimidazolium Hexafluorophosphate, Diethylammonium Formate, and Water.

Langmuir 2018 07 21;34(26):7776-7783. Epub 2018 Jun 21.

Key Laboratory of Colloid and Interface Chemistry (Ministry of Education) , Shandong University , Jinan 250100 , P. R. China.

Surfactant-free microemulsions (SFMEs) are a unique kind of microemulsion, which form from immiscible fluids (i.e., oil and water phases) in the presence of amphi-solvents rather than traditional surfactants. In comparison with traditional surfactant-based microemulsions (SBMEs), SFMEs have received much less attention, and the current understanding of the unique system is very limited. Herein, we report a SFME consisting of the hydrophobic ionic liquid (IL) 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF), the protic IL diethylammonium formate (DEAF), and water, in which the bmimPF and DEAF are used as the oil phase and amphi-solvent, respectively. Three kinds of microstructures, namely, water-in-bmimPF (W/IL), bicontinuous (BC), and bmimPF-in-water (IL/W), are identified for the SFME, using cyclic voltammetry, cryo-TEM, and DLS techniques. Especially, the volumetric and surface free energy properties of the SFME are investigated by excess molar volume ( V) and surface tension (γ) measurements, and they are found to be similar to those of SBMEs. Discontinuous changes in V and γ with the system compositions are observed as the system microstructures change, which can be used to identify the structural transition of SFMEs. We think this study provides a better understanding of SFME features.
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http://dx.doi.org/10.1021/acs.langmuir.8b00974DOI Listing
July 2018

Hypocholesterolaemic effect of whole-grain highland hull-less barley in rats fed a high-fat diet.

Br J Nutr 2018 05;119(10):1102-1110

1College of Food Science,Southwest University,Chongqing 400715,People's Republic of China.

Whole-grain highland hull-less barley (WHLB) contains high amounts of bioactive compounds that potentially exhibit cholesterol-lowering effects. This study investigated the hypocholesterolaemic effect of WHLB. A total of seventy-two male Sprague-Dawley rats were divided into four groups and were fed with the normal control diet, high-fat diet (HFD) and HFD containing low or high dose (10 or 48·95 %) of WHLB. High dose of WHLB significantly decreased the organ indexes of liver and abdominal fat and lipid levels of plasma and liver in HFD rats. The lipid regulation effect of WHLB, which was reconfirmed through hepatocyte morphologic observation, was accompanied by a large excretion of bile acids in the small intestinal contents and the faeces. Real-time PCR analyses, which were further reconfirmed through Western blot analyses, revealed that a high dose of WHLB significantly enhanced the hepatic expressions of AMP-activated protein kinase α, cholesterol 7α-hydroxylase, LDL receptor, liver X receptor, and PPARα and decreased the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. It also enhanced the ileal expression of farnesoid X receptor and resulted in the decrease of expression of apical sodium-dependent bile acid transporter. WHLB exhibited hypocholesterolaemic effects mainly by inhibiting cholesterol synthesis, cholesterol accumulation in peripheral tissue, and bile acid reabsorption and by stimulating bile acid synthesis.
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http://dx.doi.org/10.1017/S0007114518000831DOI Listing
May 2018

High power tunable mid-infrared optical parametric oscillator enabled by random fiber laser.

Opt Express 2018 Mar;26(5):6446-6455

Random fiber laser, as a kind of novel fiber laser that utilizes random distributed feedback as well as Raman gain, has become a research focus owing to its advantages of wavelength flexibility, modeless property and output stability. Herein, a tunable optical parametric oscillator (OPO) enabled by a random fiber laser is reported for the first time. By exploiting a tunable random fiber laser to pump the OPO, the central wavelength of idler light can be continuously tuned from 3977.34 to 4059.65 nm with stable temporal average output power. The maximal output power achieved is 2.07 W. So far as we know, this is the first demonstration of a continuous-wave tunable OPO pumped by a tunable random fiber laser, which could not only provide a new approach for achieving tunable mid-infrared (MIR) emission, but also extend the application scenarios of random fiber lasers.
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http://dx.doi.org/10.1364/OE.26.006446DOI Listing
March 2018

Flexible spectral manipulation property of a high power linearly polarized random fiber laser.

Sci Rep 2018 02 1;8(1):2173. Epub 2018 Feb 1.

College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha, 410073, China.

Fiber lasers with flexible spectral manipulation property could provide a flexible tool for scenes where the temporal coherence property accounts, for example, coherent sensing/communication and nonlinear frequency conversion. Due to the good laser performance and relative simplicity of implementation, random fiber lasers (RFLs) based on random distributed feedback and Raman gain have earned more and more attention in the past few years, and a variety of RFLs with substantially different spectral properties have been developed. In this presentation, we demonstrate a high power linearly polarized RFL with flexible spectral manipulation property, in which the central wavelength and the linewidth of the spectrum can be tuned independently through a bandwidth-adjustable tunable optical filter (BA-TOF). The central wavelength of the RFL can be continuously tuned from 1095 to 1115 nm, while the full width at half-maximum (FWHM) linewidth has a maximal tuning range from ~0.6 to more than 2 nm. Moreover, the output power of 1102.5-1112.5 nm reaches ~23 W with polarization extinction ratio (PER) value > 20 dB. To the best of our knowledge, this is the first demonstration of a powerful linearly polarized RFL with both wavelength and linewidth tunability.
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http://dx.doi.org/10.1038/s41598-018-20664-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795014PMC
February 2018

Assessment for facial nerve paralysis based on facial asymmetry.

Australas Phys Eng Sci Med 2017 Dec 31;40(4):851-860. Epub 2017 Oct 31.

School of Computer Engineering and Science, Shanghai University, Shanghai, 200444, China.

Facial nerve paralysis (FNP) is a loss of facial movement due to facial nerve damage, which will lead to significant physical pain and abnormal function in patients. Traditional FNP grading methods are solely based on clinician's judgment and are time-consuming and subjective. Hence, an accurate, quantitative and objective method of evaluating FNP is proposed for constructing a standard system, which will be an invaluable tool for clinicians who treat the patient with FNP. In this paper, we introduce a novel method for quantitative assessment of FNP which combines an effective facial landmark estimation (FLE) algorithm and facial asymmetrical feature (FAF) by processing facial movement image. The facial landmarks can be detected automatically and accurately using FLE. The FAF is based on the angle of key facial landmark connection and mirror degree of multiple regions on human face. Our method provides significant contribution as it describes the displacement of facial organ and the changes of facial organ exposure during performing facial movements. Experiments show that our method is effective, accurate and convenient in practice, which is beneficial to FNP diagnosis and personalized rehabilitation therapy for each patient.
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http://dx.doi.org/10.1007/s13246-017-0597-4DOI Listing
December 2017

Synthesis of hierarchical flower-like MgAl-Cl layered double hydroxide in a surfactant-free reverse microemulsion.

J Colloid Interface Sci 2017 Nov 24;505:816-823. Epub 2017 Jun 24.

Key Laboratory of Colloid and Interface Chemistry (Ministry of Education), Shandong University, Jinan 250100, PR China. Electronic address:

Hierarchical flower-like MgAl-Cl LDH microspheres were synthesized using a reverse surfactant-free microemulsion (SFME) route at a low temperature (∼25°C), and characterized by XRD, TEM, SEM, FT-IR, TG, N adsorption/desorption, and elemental analyses. The SFME used consists of n-hexane, isopropanol, and water. The so-obtained flower-like microspheres are constructed with LDH nanosheets with ∼10nm thickness. After destroyed by calcination, their crystal structure and flower-like morphology can be reconstructed by rehydration. The flower-like LDH and its calcined product (CLDH) have large specific surface areas being ∼84.3 and 163.9mg, respectively. The sorption of methyl orange (MO) on the LDH and CLDH were determined, showing high MO sorption capacities of ∼559 and 1112gg, respectively, which are obviously higher than those reported for conventional LDHs and CLDHs. Possible mechanisms for the flower-like microsphere formation and the MO sorption are discussed. Our results demonstrate that, like traditional surfactant-based microemulsions, SFMEs as microreactors or templates can be used to synthesize nanomaterials. The hierarchical flower-like LDH microspheres and their calcined product have potential applications such as in the treatment of organic waste water.
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http://dx.doi.org/10.1016/j.jcis.2017.06.080DOI Listing
November 2017

Hypolipidaemic effect and mechanism of paprika seed oil on Sprague-Dawley rats.

J Sci Food Agric 2017 Sep 2;97(12):4242-4249. Epub 2017 May 2.

College of Food Science, Southwest University, Chongqing, China.

Background: Details regarding the functional properties of paprika seed oil are relatively scarce. In this study the hypolipidaemic effects and mechanisms of paprika seed oil on Sprague-Dawley rats are explored, which may improve the usage of paprika seed source and provide a theoretical basis of paprika seed oil for the alleviation of hyperlipidaemia.

Results: In capsaicin and paprika seed oil (PSO) groups, total cholesterol (TC) and total triglyceride (TG) in serum and liver lipids of rats were significantly decreased (P < 0.05). The contents of serum HDL cholesterol were increased and the contents of serum LDL cholesterol were decreased (P < 0.05). Real-time PCR analyses revealed that the hepatic mRNA expression of fatty acid synthetase (FAS) is decreased and the expression levels of HSL is increased (P < 0.05). The mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is decreased and the expression levels of low-density lipoprotein receptor (LDLR) is significantly improved (P < 0.05). The cholesterol 7-hydroxylase (CYP7A1) expression is regulated to control the cholesterol-to-bile acid transformation and cholesterol excretion is promoted. Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARα).

Conclusion: The hypolipidaemic effects of paprika seed oil (PSO) may be attributed to the inhibition of lipid synthesis via suppressing the expression of HMG-CoAR, CYP7A1 and FAS, meanwhile, promoting the metabolism and excretion of lipids via up-regulating the expression of LDLR, HSL, TRPV1 and PPARα. © 2017 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.8300DOI Listing
September 2017

[Chiral separation of six tetralone derivative enantiomers using immobilized cellulose chiral stationary phase].

Se Pu 2014 Aug;32(8):832-6

A high performance liquid chromatographic method (HPLC) was developed for the chiral separation of six α-aryl tetralone derivatives, using a Chiralpak IC column. The factors influencing the chiral separation including the type and concentration of organic modifier, column temperature and flow rate were investigated. The results showed that high enantiomeric separation can be obtained with isopropanol as modifier for the six compounds. The thermodynamic study indicated that the enantioseparation was enthalpically driven and showed that low column temperature was beneficial to separation. Complete separation of compound I was achieved with a binary solvent mixture of n-hexane-isopropanol (90 :10, v/v) as the recommended mobile phase. The compounds II , II and IV were separated with the mobile phase of the mixture of n-hexane-isopropanol (99:1, v/v) and the compound V was separated with the mixture of n-hexane-isopropanol (85:15, v/v). The compound VI was separated with the mixture of n-hexane-isopropanol (80:20, v/v). The column temperature was 25 °C, and the flow rate was 1. 0 mL/min. The six tetralone derivative enantiomers were separated on a chiral stationary phase of Chiralpak IC by HPLC. The column has high enantiomeric selectivity to the six tetralone derivative enantiomers.
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http://dx.doi.org/10.3724/sp.j.1123.2014.03035DOI Listing
August 2014
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