Publications by authors named "Jiaxin Li"

249 Publications

Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.

ACS Biomater Sci Eng 2021 Oct 12. Epub 2021 Oct 12.

College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.

Photothermal therapy (PTT) using nanoparticles is one of the research hotspots in the field of cancer therapy. However, the thermal resistance of tumor cells and the elimination of nanoparticles by the body's immune system reduce their therapeutic effect. Therefore, it is essential to reduce heat resistance, improve their biocompatibility, and reduce the clearance of the immune system. In this work, we constructed a biomimetic platform for cancer therapy based on heat shock protein (HSP) inhibitors, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG))-loaded and platelet membrane (PM)-coated mesoporous platinum nanoparticles (MPNPs). First, MPNPs with the properties of chemotherapy and PTT were synthesized to load 17-DMAG (17-DMAG/MPNPs). Then, they were coated with PM for tumor targeting and improved biocompatibility to obtain the final bionic nanotherapy platform 17-DMAG/[email protected] The results in vivo and in vitro showed that 17-DMAG/[email protected] could accumulate in the tumor and effectively inhibit the growth of tumor cells. Therefore, the biomimetic nanotherapy system is expected to provide new ideas for cancer treatment.
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http://dx.doi.org/10.1021/acsbiomaterials.1c00912DOI Listing
October 2021

Association Between Lipid Accumulation Product and Target Organ Damage in Elderly Population: The Northern Shanghai Study.

Clin Interv Aging 2021 2;16:1769-1776. Epub 2021 Oct 2.

Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.

Introduction: Lipid accumulation product (LAP), calculated from waist circumference (WC) and triglycerides (TG), is a novel index that correlates cardiovascular disease. We aimed to investigate the relationship between LAP and target organ damage (TOD) in elderly Chinese community-dwelling individuals.

Materials And Methods: We enrolled 3363 participants whose age was ≥65 years old. TOD, including left ventricular hypertrophy (LVH), arterial stiffness (AS), lower extremity atherosclerotic (LEA), micro-albuminuria (MAU) and chronic kidney disease (CKD), was measured using standard methods. LAP was calculated as (WC-65) × TG in men and (WC-58) × TG in women. Both quartiles and continuation of LAP were analyzed.

Results: Age-sex adjusted partial correlation analysis showed that LAP was significantly associated with CVD risk factors. With the first quartile (Q1) as a reference, in univariate logistic regression, the fourth quartile (Q4) of LAP was associated with all TOD. In multivariate model, Q4 of LAP was only associated with an increased risk of AS (odds ratio (OR) = 1.88, 95% confidence interval (CI): 1.37-2.58, P < 0.001), MAU (OR = 1.33, 95% CI: 1.01-1.75, P = 0.02) and CKD (OR = 2.39, 95% CI: 1.39-4.12, P < 0.001). But, Q4 of LAP was not associated with an increased risk of LVH (OR = 1.19, 95% CI: 0.85-1.65, P = 0.25) or LEA (OR = 0.87, 95% CI: 0.58-1.29, P = 0.96). Similar associations were found when analyzed continuously.

Conclusion: The novel metabolic parameter LAP is significantly and independently associated with an increased risk of arterial stiffness, chronic kidney disease and micro-albuminuria in Chinese community-dwelling elderly individuals.
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http://dx.doi.org/10.2147/CIA.S330313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495140PMC
October 2021

Microglial Phenotypic Transition: Signaling Pathways and Influencing Modulators Involved in Regulation in Central Nervous System Diseases.

Front Cell Neurosci 2021 14;15:736310. Epub 2021 Sep 14.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Microglia are macrophages that reside in the central nervous system (CNS) and belong to the innate immune system. Moreover, they are crucially involved in CNS development, maturation, and aging; further, they are closely associated with neurons. In normal conditions, microglia remain in a static state. Upon trauma or lesion occurrence, microglia can be activated and subsequently polarized into the pro-inflammatory or anti-inflammatory phenotype. The phenotypic transition is regulated by numerous modulators. This review focus on the literature regarding the modulators and signaling pathways involved in regulating the microglial phenotypic transition, which are rarely mentioned in other reviews. Hence, this review provides molecular insights into the microglial phenotypic transition, which could be a potential therapeutic target for neuroinflammation.
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http://dx.doi.org/10.3389/fncel.2021.736310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476879PMC
September 2021

Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction.

ESC Heart Fail 2021 Sep 27. Epub 2021 Sep 27.

Heart Failure and Structural Cardiology Division, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Aims: There is an emerging interest in elucidating the natural history and prognosis for patients with heart failure with reduced ejection fraction (HFrEF) in whom left ventricular ejection fraction (LVEF) subsequently improves. The characteristics and outcomes were compared between heart failure with recovered ejection fraction (HFrecEF) and persistent HFrEF.

Methods And Results: This is a retrospective study of adults who underwent at least two echocardiograms 3 months apart between 1 November 2015 and 31 October 2019 with an initial diagnosis of HFrEF. The subjects were divided into HFrecEF group (second LVEF > 40%, ≥10% absolute improvement in LVEF) and persistent HFrEF group (<10% absolute improvement in LVEF) according to the second LVEF. To further study the characteristics of HFrecEF patients, the cohort was further divided into LVEF improvement of 10-20% and >20% subgroups. The primary outcomes were all-cause mortality and rehospitalization. A total of 1160 HFrEF patients were included [70.2% male, mean (standard deviation) age: 62 ± 13 years]. On the second echocardiogram, 284 patients (24.5%) showed HFrecEF and 876 patients (75.5%) showed persistent HFrEF. All-cause mortality was identified in 23 (8.10%) HFrecEF and 165 (18.84%) persistent HFrEF, whilst 76 (26.76%) and 426 (48.63%) showed rehospitalizations, respectively. Survival analysis showed that the persistent HFrEF subgroup experienced a significantly higher mortality at 12 and 24 months and a higher hospitalization at 12, 24, 48, and more than 48 months following discharge. Multivariate Cox regression showed that persistent HFrEF had a higher risk of all-cause mortality [hazard ratio (HR) 2.30, 95% confidence interval (CI) 1.49-3.56, P = 0.000] and rehospitalization (HR 1.85, 95% CI 1.45-2.36, P = 0.000) than the HFrecEF group. Subgroup analysis showed that the LVEF ≥ 20% improvement subgroup had lower rates of adverse outcomes compared with those with less improvement of 10-20%.

Conclusions: Heart failure with recovered ejection fraction is a distinct HF phenotype with better clinical outcomes compared with those with persistent HFrEF. HFrecEF patients have a relatively better short-term mortality at 24 months but not thereafter.
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http://dx.doi.org/10.1002/ehf2.13630DOI Listing
September 2021

Biological Functions of Let-7e-5p in Promoting the Differentiation of MC3T3-E1 Cells.

Front Cell Dev Biol 2021 8;9:671170. Epub 2021 Sep 8.

College of Animal Science, Jilin University, Changchun, China.

MicroRNAs let-7c and let-7f, two members of the let-7 family, were involved in regulating osteoblast differentiation and have an important role in bone formation. Let-7e-5p, which also belonged to the let-7 family, presented in the differentiation of adipose-derived stem cells and mouse embryonic stem cells. However, the role of let-7e-5p in osteoblast differentiation was unclear. Thus, this study aimed to elucidate the function of let-7e-5p in osteoblast differentiation and its mechanism. Firstly, we found that the let-7e-5p mimic promoted osteoblast differentiation but not the proliferation of MC3T3-E1 cells by positively regulating the expression levels of osteogenic-associated genes (, , , and ), the activity of ALP, and formation of mineralized nodules. Moreover, we ascertained that the let-7e-5p mimic downregulated the post-transcriptional expression of SOCS1 by specifically binding to the 3' untranslated region of SOCS1 mRNA. Also, let-7e-5p-induced SOCS1 downregulation increased the protein levels of p-STAT5 and IGF-1, which were both modulated by SOCS1 molecules. Furthermore, let-7e-5p abrogated the inhibition of osteogenic differentiation mediated by SOCS1 overexpression. Therefore, these results suggested that let-7e-5p regulated the differentiation of MC3T3-E1 cells through the JAK2/STAT5 pathway to upregulate IGF-1 gene expression by inhibiting SOCS1. These findings may provide a new insight into the regulatory role of let-7e-5p in osteogenic differentiation and imply the existence of a novel mechanism underlying let-7e-5p-mediated osteogenic differentiation.
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http://dx.doi.org/10.3389/fcell.2021.671170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455882PMC
September 2021

Contralateral risk-reducing local therapy in breast cancer patients with BRCA1/2 mutations: systemic review and meta-analysis.

Cancer Cell Int 2021 Sep 25;21(1):512. Epub 2021 Sep 25.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.

Background: Unilateral breast cancer (UBC) patients with germline pathogenic BRCA1/2 variants have a higher risk of developing contralateral breast cancer (CBC) and need contralateral risk-reducing local treatments, including contralateral risk-reducing mastectomy (CRRM) and prophylactic irradiation (CPI). The aim of our study was to systematically explore the efficacy of CRRM and CPI in reducing CBC risk and increasing survival.

Methods: A search was done, and eligible randomized trials and cohort studies should include and compare UBC patients with germline pathogenic BRCA1/2 variants who have and have not received contralateral risk-reducing local treatment. Random-effects meta-analysis was used in this study. Primary outcomes of the studies included overall survival (OS) and the incidence of contralateral breast cancer (CBC), and secondary outcomes included breast cancer-specific survival (BCSS).

Results: A total of five studies with 1769 UBC patients with germline pathogenic BRCA1/2 variants were enrolled in our meta-analysis. CRRM was correlated with a lower risk of CBC in UBC patients with germline pathogenic BRCA1/2 variants (summary RR = 0.07; 95%CI 0.03-0.13, I = 3%), a significantly increased OS (summary RR, 1.15; 95%CI 1.04-1.26, I = 26%) and a significantly increased BCSS (summary RR, 1.18; 95%CI 1.07-1.31, I = 64%) compared with surveillance. CPI also decreased the risk of CBC (RR 0.02; 95%CI 0.05-0.88) but did not significantly improve OS (RR 0.97; 95%CI 0.90-1.05) and BCSS (RR 0.97; 95%CI 0.90-1.05) compared with surveillance.

Conclusions: CRRM reduces CBC risk and increases OS and BCSS in UBC patients with germline pathogenic BRCA1/2 variants, and could be offered as a risk-reducing local treatment. For those who oppose CRRM, CPI could be offered for CBC-risk reduction, while its survival benefit is still uncertain.
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http://dx.doi.org/10.1186/s12935-021-02194-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466340PMC
September 2021

lncRNA DSCR8 mediates miR-137/Cdc42 to regulate gastric cancer cell proliferation, invasion, and cell cycle as a competitive endogenous RNA.

Mol Ther Oncolytics 2021 Sep 29;22:468-482. Epub 2021 May 29.

Department of Gastrointestinal Surgery, Lishui People's Hospital of Zhejiang Province, 15 Dazhong Street, Liandu District, Lishui City, Zhejiang 323000, China.

lncRNA DSCR8 (Down syndrome critical region 8) is involved in progression of many cancers, but its specific role in gastric cancer (GC) is still unclear. Here, qRT-PCR detected upregulated expression of DSCR8 and Cdc42 and downregulated expression of miR-137 in GC. The protein expression level of Cdc42 in GC was upregulated as tested by western blot. Statistical analysis showed that DSCR8 was closely associated with some malignant clinicopathological features (such as tumor size, metastasis, and stage) in GC patients. Fluorescence hybridization showed that DSCR8 was localized in the nucleus and cytoplasm. Dual-luciferase reporter gene, RNA immunoprecipitation, and biotin pull-down assays showed that DSCR8 could bind to miR-137 could bind to Cdc42. and assays showed that DSCR8 could promote proliferation, invasion, and the cycle of GC cells and inhibit cell apoptosis. In addition, a rescue experiment showed that DSCR8 regulated progression of GC cells via miR-137. Furthermore, DSCR8 regulated Cdc42 in GC cells by inhibiting miR-137. Taken together, these data indicated that DSCR8 could adsorb miR-137 to reduce its inhibitory effect on Cdc42 expression, thereby promoting the progression of GC cells and regulating the cell cycle. These results provide a novel direction for DSCR8 as a target of GC.
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http://dx.doi.org/10.1016/j.omto.2021.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430047PMC
September 2021

How does satisfaction of solar PV users enhance their trust in the power grid? - Evidence from PPAPs in rural China.

Energy Sustain Soc 2021 16;11(1):31. Epub 2021 Sep 16.

School of Foreign Languages, China University of Geosciences, No. 388 Lumo Road, Hongshan District, Wuhan, 430074 Hubei China.

Background: Photovoltaic Poverty Alleviation Projects (PPAPs) have been implemented in Chinese rural areas since 2014. As a new energy policy, PPAPs have played an important role in alleviating rural poverty. However, the adoption of solar PV faces multiple barriers from the perspective of beneficiaries. Therefore, this study aims to discuss and analyze factors affecting beneficiaries' satisfaction and their trust in State Grid, promoting the adoption of solar PV.

Methods: Based on the integrated American Customer Satisfaction Index (ACSI) and Unified Theory of Acception and Use of Technology (UTAUT) model, this study used the Structural Equation Model (SEM) to reveal how the beneficiaries' satisfaction enhance their trust in State Grid. The data were obtained from a survey of 928 PPAPs' beneficiaries by stratified and random sampling in Chinese rural areas.

Results: The results confirm that environmental perception in this study has positive impact on beneficiaries' satisfaction. In addition, perceived quality also has a positive effect on beneficiaries' satisfaction and trust in State Grid; however, social influence has a negative impact on beneficiaries' satisfaction; behavior expectation can directly promote beneficiaries' satisfaction while indirectly propel their trust in State Grid.

Conclusions: This study constructs an integrated customer satisfaction model from the perspective of beneficiaries and proposes relevant measures to promote the adoption of solar PV that can be applied to poverty reduction in other developing countries worldwide.
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http://dx.doi.org/10.1186/s13705-021-00306-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443908PMC
September 2021

Predicting attractiveness from face parts reveals multiple covarying cues.

Br J Psychol 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychology, Renmin University of China, Beijing, China.

In most studies of facial attractiveness perception, judgments are based on the whole face images. Here we investigated how attractiveness judgments from parts of faces compare to perceived attractiveness of the whole face, and to each other. We manipulated the extent and regions of occlusion, where either the left/right or the top/bottom half of the face was occluded. We also further segmented the face into relatively small horizontal regions involving the forehead, eyes, nose, or mouth. The results demonstrated the correlated nature of face regions, such that an attractiveness judgment for one face part can be highly predictive of the attractiveness of the whole face or the other parts. The left/right half of the face created more accurate predictions than the top/bottom half. Judgments involving a larger area of the face (i.e., left/right or top/bottom halves) produced more accurate predictions than those derived from smaller regions, such as the eyes or the mouth alone, but even the smallest and most featureless region investigated (the forehead) provided useful information. The correlated nature of the attractiveness of face parts shows that perceived attractiveness is determined by multiple covarying cues that the visual system can exploit to determine attractiveness from a single glance.
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http://dx.doi.org/10.1111/bjop.12532DOI Listing
September 2021

Polydopamine-based nanoplatform for photothermal ablation with long-term immune activation against melanoma and its recurrence.

Acta Biomater 2021 Sep 16. Epub 2021 Sep 16.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

The high risk of tumor recurrence presents a big challenge in melanoma therapy. Photothermal therapy (PTT) has merged as a powerful weapon against tumor in recent years, which produces tumor-associated antigens (TAA) and recruits dendritic cells (DCs) to tumor sites through immunogenic cell death (ICD) for immune activation. However, due to the lack of activation signals of DCs, the immune effect induced by PTT is not sufficient to inhibit the recurrence and proliferation of tumor. To efficiently cooperate PTT and immunotherapy to circumvent tumor recurrence, here we constructed a polydopamine (PDA) based core-shell nanoplatform loading CpG ODNs to elicit robust photothermal ablation and antitumor immune responses. Cationized polydopamine coated with hyaluronic acid (HA) shell was proven an efficient photothermal agent that increased the surface temperature of tumor by 16 °C and induced ICD. CpG ODNs effectively induced maturation of DCs by elevating the expression of co-stimulating markers. PTT combined with CpG ODNs achieved a remarkable synergistic treatment effect in the maturation of DCs and activation of T cells in melanoma-bearing mice model compared with PTT or CpG ODNs alone. Furthermore, in a tumor recurrence model, photothermal-immune combination therapy increased the infiltration of CTLs in distant tumor compared with PTT or CpG ODNs alone. The combination therapy overcame insufficient immunity at distant tumor caused by PTT alone and relieved immunosuppression microenvironment of the tumor. Hence, the PDA based core-shell nanoplatform presents a potent photo-immunotherapy against proliferation and recurrence of melanoma. STATEMENT OF SIGNIFICANCE: In order to solve the insufficient immunity induced by photothermal therapy (PTT), CpG ODNs were utilized to enhance the weak immune response mediated by PTT through inducing DCs maturation. Hence, we designed a polydopamine (PDA) based core-shell nanoplatform loading CpG ODNs followed by hyaluronic acid named PPP/CpG/HA to elicit robust photothermal ablation and antitumor immune responses. CpG ODNs were delivered to the tumor site through the targeting effect of the HA shell. The core-shell nanoplatform achieved a remarkable synergistic treatment effect in the maturation of DCs and activation of T cells, thereby overcoming insufficient immunity at distant tumor caused by PTT alone. The core-shell nanoplatform presents a potent photo-immunotherapy against proliferation and recurrence of melanoma.
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http://dx.doi.org/10.1016/j.actbio.2021.09.014DOI Listing
September 2021

Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update.

Front Pharmacol 2021 30;12:707696. Epub 2021 Aug 30.

Innovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Neuroinflammatory response is the immune response mechanism of the innate immune system of the central nervous system. Both primary and secondary injury can activate neuroinflammatory response. Among them, the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a key role in the inflammatory response of the central system. Inflammasome is a type of pattern recognition receptor, a cytoplasmic polyprotein complex composed of members of the Nod-like receptor (NLR) family and members of the pyrin and HIN domain (PYHIN) family, which can be affected by a variety of pathogen-related molecular patterns or damage-related molecular patterns are activated. As one of the research hotspots in the field of medical research in recent years, there are increasing researches on immune function abnormalities in the onset of neurological diseases such as depression, AD, ischemic brain injury and cerebral infarction, the NLRP3 inflammasome causes the activated caspase-1 to cleave pre-interleukin-1β and pre-interleukin-18 into mature interleukin-1β and interleukin-18, in turn, a large number of inflammatory factors are produced, which participate in the occurrence and development of the above-mentioned diseases. Targeted inhibition of the activation of inflammasomes can reduce the inflammatory response, promote the survival of nerve cells, and achieve neuroprotective effects. This article reviews NLRP3 inflammasome's role in neurological diseases and related regulatory mechanisms, which providing references for future research in this field.
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http://dx.doi.org/10.3389/fphar.2021.707696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435574PMC
August 2021

Mutation of the sixth amino acid of the Rep protein has no effect on porcine circovirus 2b but enhances porcine circovirus 2d replication in vitro.

Arch Virol 2021 Nov 15;166(11):3189-3192. Epub 2021 Sep 15.

Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, 88 East Wenhua Rd., Jinan, 250014, People's Republic of China.

Porcine circovirus type 2 (PCV2) is the etiological agent of post-weaning multisystemic wasting syndrome (PMWS). The original prevalent genotype, PCV2a, has been replaced by genotypes 2b and 2d in the swine population worldwide. The Rep protein is critical for viral replication. Comparison of a large number of Rep protein amino acid (aa) sequences showed that three sites distinguish genotype 2b from genotype 2d. In order to analyze the effect of exchanging the amino acids (asparagine and serine) at position 6 in the Rep proteins of PCV2b and PCV2d, two wild-type and two mutant viruses were rescued. Real-time quantitative PCR and a one-step growth curve were used to determine the viral load to assess the replication ability of the rescued viruses. The results showed that there was no significant difference in in vitro performance between the wild-type PCV2b and the mutated virus, while the mutation of PCV2d enhanced viral replication.
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http://dx.doi.org/10.1007/s00705-021-05217-5DOI Listing
November 2021

Quality of Life and Hope of Women in China Receiving Chemotherapy for Breast Cancer.

Clin Nurs Res 2021 Sep 14:10547738211046737. Epub 2021 Sep 14.

Jilin University, Changchun, China.

We explore the association of hope and quality of life in breast cancer chemotherapy women. Their quality of life is related to treatment effects and disease outcomes. This cross-sectional study was conducted in City, China, in 2017. In a convenience sampling, 450 women who underwent breast cancer chemotherapy were selected from two hospitals. Descriptive statistics, single-factor analysis, Spearman correlation, linear regression, and structural equation modeling were used to analyze data. The mean quality of life score was 65.65. In linear regression analysis, we found patients' quality of life was significantly related to age, marital status, education level, chemotherapy cycle, and hope. Structural equation results showed the "temporality and future" and "interconnectedness" subscales of the HHI explained 43% of the variance in quality of life. We found hope is an important aspect in quality of life, and further research is needed to determine if nurses can influence this aspect of care.
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http://dx.doi.org/10.1177/10547738211046737DOI Listing
September 2021

Research on improved convolutional wavelet neural network.

Sci Rep 2021 09 9;11(1):17941. Epub 2021 Sep 9.

Information Department, Beijing University of Technology, Beijing, 100124, China.

Artificial neural networks (ANN) which include deep learning neural networks (DNN) have problems such as the local minimal problem of Back propagation neural network (BPNN), the unstable problem of Radial basis function neural network (RBFNN) and the limited maximum precision problem of Convolutional neural network (CNN). Performance (training speed, precision, etc.) of BPNN, RBFNN and CNN are expected to be improved. Main works are as follows: Firstly, based on existing BPNN and RBFNN, Wavelet neural network (WNN) is implemented in order to get better performance for further improving CNN. WNN adopts the network structure of BPNN in order to get faster training speed. WNN adopts the wavelet function as an activation function, whose form is similar to the radial basis function of RBFNN, in order to solve the local minimum problem. Secondly, WNN-based Convolutional wavelet neural network (CWNN) method is proposed, in which the fully connected layers (FCL) of CNN is replaced by WNN. Thirdly, comparative simulations based on MNIST and CIFAR-10 datasets among the discussed methods of BPNN, RBFNN, CNN and CWNN are implemented and analyzed. Fourthly, the wavelet-based Convolutional Neural Network (WCNN) is proposed, where the wavelet transformation is adopted as the activation function in Convolutional Pool Neural Network (CPNN) of CNN. Fifthly, simulations based on CWNN are implemented and analyzed on the MNIST dataset. Effects are as follows: Firstly, WNN can solve the problems of BPNN and RBFNN and have better performance. Secondly, the proposed CWNN can reduce the mean square error and the error rate of CNN, which means CWNN has better maximum precision than CNN. Thirdly, the proposed WCNN can reduce the mean square error and the error rate of CWNN, which means WCNN has better maximum precision than CWNN.
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http://dx.doi.org/10.1038/s41598-021-97195-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429473PMC
September 2021

Simultaneous inhibition of breast cancer and its liver and lung metastasis by blocking inflammatory feed-forward loops.

J Control Release 2021 Oct 1;338:662-679. Epub 2021 Sep 1.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

Inflammatory feed-forward loops including the steps of "inflammatory cell recruitment", "inflammatory signaling pathway activation" and "inflammatory factor production" are essential in the development of breast cancer and its metastasis. Herein, a doxorubicin-loaded micellar low-molecular-weight-heparin-astaxanthin nanoparticle (LMWH-AST/DOX, LA/DOX NP) was developed. The hydrophilic LMWH could decrease the recruitment of neutrophils in liver and myeloid-derived suppressor cells (MDSCs) in lung and tumor through P-selectin blockage. The hydrophobic AST could inhibit nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) signaling pathways. Therefore, LA/DOX NPs could block these loops and suppress the liver metastasis by inhibiting the formation of neutrophil extracellular traps (NETs), inhibit the lung metastasis and alleviate the inflammatory and immunosuppressive microenvironment in tumor. This is the first functional nanoparticle reported to shut down inflammatory feed-forward loops and the formation of NETs, which provides a promising therapeutic strategy for breast cancer and its liver and lung metastasis.
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http://dx.doi.org/10.1016/j.jconrel.2021.08.047DOI Listing
October 2021

Characterization of the flavor and nutritional value of coconut water vinegar based on metabolomics.

Food Chem 2022 Feb 16;369:130872. Epub 2021 Aug 16.

School of Science, Hainan University, Haikou 570228, China; Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou 570228, China; Key Laboratory of Tropical Agricultural Products Processing Technology of Haikou City, Haikou 570228, China. Electronic address:

Tender Coconut water is popular for its deliciousness and nutrition. Mature coconut water, usually discarded as waste in the coconut kernel-based food industry due to its unpleasant flavor, was used as a raw material to make vinegar by liquid-state fermentation. The compounds in fresh coconut water with high odor activity values (OAVs) were isovaleric acid and acetic acid, with pungent sour tastes. The compounds with high OAVs in aged coconut water vinegar were phenylethyl acetate, isoamyl acetate and benzaldehyde, with almond, banana or pear-like aromas. Coconut water vinegar was rich in essential amino acids, especially phenylalanine. Through pathway analysis, seventeen key metabolic pathways and three key metabolic substrates (aspartate, glutamate and pyruvate) were found. According to sensory evaluation, the aged vinegar tastes better. Coconut water vinegar is delicious and nutritious, so reprocessing mature coconut water into vinegar is an appropriate way to reuse waste coconut water.
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http://dx.doi.org/10.1016/j.foodchem.2021.130872DOI Listing
February 2022

Evolution of the Electromagnetic Manipulation: From Tunable to Programmable and Intelligent Metasurfaces.

Micromachines (Basel) 2021 Aug 20;12(8). Epub 2021 Aug 20.

College of Electronics and Information Engineering, Shanghai University of Electric Power, Shanghai 200090, China.

Looking back on the development of metamaterials in the past 20 years, metamaterials have gradually developed from three-dimensional complex electromagnetic structures to a two-dimensional metasurface with a low profile, during which a series of subversive achievements have been produced. The form of electromagnetic manipulation of the metasurface has evolved from passive to active tunable, programmable, and other dynamic and real-time controllable forms. In particular, the proposal of coding and programmable metasurfaces endows metasurfaces with new vitality. By describing metamaterials through binary code, the digital world and the physical world are connected, and the research of metasurfaces also steps into a new era of digitalization. However, the function switch of traditional programmable metamaterials cannot be achieved without human instruction and control. In order to achieve richer and more flexible function regulation and even higher level metasurface design, the intelligence of metamaterials is an important direction in its future development. In this paper, we review the development of tunable, programmable, and intelligent metasurfaces over the past 5 years, focusing on basic concepts, working principles, design methods, manufacturing, and experimental validation. Firstly, several manipulation modes of tunable metasurfaces are discussed; in particular, the metasurfaces based on temperature control, mechanical control, and electrical control are described in detail. It is demonstrated that the amplitude and phase responses can be flexibly manipulated by the tunable metasurfaces. Then, the concept, working principle, and design method of digital coding metasurfaces are briefly introduced. At the same time, we introduce the active programmable metasurfaces from the following aspects, such as structure, coding method, and three-dimensional far-field results, to show the excellent electromagnetic manipulation ability of programmable metasurfaces. Finally, the basic concepts and research status of intelligent metasurfaces are discussed in detail. Different from the previous programmable metamaterials, which must be controlled by human intervention, the new intelligent metamaterials control system will realize autonomous perception, autonomous decision-making, and even adaptive functional manipulation to a certain extent.
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http://dx.doi.org/10.3390/mi12080988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399928PMC
August 2021

Complementary sample preparation strategies (PVD/BEXP) combining with multifunctional SPM for the characterizations of battery interfacial properties.

MethodsX 2021 26;8:101250. Epub 2021 Jan 26.

College of Physics and Energy, Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, Fujian Normal University, Fuzhou 350117, China.

The cathode/anode-electrolyte interfaces in lithium/sodium ion batteries act as the "gate" for the ion exchange between the solid electrode and liquid electrolyte. Understanding the interfacial properties of these solid-liquid interfaces is essential for better design high-performance lithium/sodium ion batteries. Here, we provide a novel method for studying solid-liquid interfacial properties of battery materials through combining physical vapor deposition (PVD) and beam-exit cross-sectional polishing (BEXP) followed by controlled environment multifunctional Scanning Probe Microscope (SPM). In this method, commercial battery materials can be either directly grown on the current collector substrates, or polished by obliqued Ar-ion beams to get a nanoscale flat surface which allows the multifunctional SPM to study sample directly in the liquid electrolyte or in protective oxygen/HO free environment. This approach allows to investigate wide range of interfacial properties, including surface morphology, internal cracks, mechanical properties, electronic/ionic conductivity and surface potential, with nanoscale resolution in-operando during the battery cycles as well as post-mortem.•PVD and novel BEXP methods were introduced to prepare battery powder materials as perfect specimens for nanoscale SPM characterization.•Various physical/chemical properties of battery materials can be probed on the as-prepared specimens under liquid electrolyte using in situ/operando SPM techniques.•Ex situ/post-mortem analyses based on the controlled environment multifunction SPM characterizations can be achieved in the BEXP polished degradation battery electrodes.
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http://dx.doi.org/10.1016/j.mex.2021.101250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374284PMC
January 2021

Isovitexin is a direct inhibitor of coagulase.

J Microbiol Biotechnol 2021 Aug 12;31(10). Epub 2021 Aug 12.

College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China.

(S. aureus) is a major pathogen that causes human pneumonia, leading to significant morbidity and mortality. coagulase (Coa) triggers the polymerization of fibrin by activating host prothrombin, which then converts fibrinogen to fibrin and contributes to pathogenesis and persistent infection. In our research, we demonstrate that isovitexin, an active traditional Chinese medicine component, can inhibit the coagulase activity of Coa but does not interfere with the growth of . Furthermore, we show through thermal shift and fluorescence quenching assays that isovitexin directly binds to Coa. Dynamic simulation and structure-activity relationship analyses suggest that V191 and P268 are key amino acid residues responsible for the binding of isovitexin to Coa. Taken together, these data indicate that isovitexin is a direct Coa inhibitor and a promising candidate for drug development against infection.
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http://dx.doi.org/10.4014/jmb.2105.05013DOI Listing
August 2021

Anti-vascular endothelial growth factor therapy in breast cancer: Molecular pathway, potential targets, and current treatment strategies.

Cancer Lett 2021 Nov 10;520:422-433. Epub 2021 Aug 10.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

As the highest incidence of female malignancy, breast cancer is likewise the leading cause of cancer-related deaths. The development of cancer relies on neo-vascularization, which provides sufficient nutrition and oxygen, and supplies a pathway for distant metastasis. Angiogenesis represents the formation of new blood vessels, and is a principal pathogenetic action in breast cancer. Vascular endothelial growth factor (VEGF) is a major angiogenesis regulator that modulates the maintenance and function of mature vascular networks. Therefore, the VEGF pathway is a promising oncotherapeutic target. This review elaborates an update on the prognostic value of VEGF in breast cancer, summarizes clinical experience and lessons of anti-VEGF therapeutics, meanwhile, provides an overview of biomarkers that predict the effectiveness of anti-angiogenic treatment.
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http://dx.doi.org/10.1016/j.canlet.2021.08.005DOI Listing
November 2021

Food Consumption Behavior of Pakistani Students Living in China: The Role of Food Safety and Health Consciousness in the Wake of Coronavirus Disease 2019 Pandemic.

Front Psychol 2021 27;12:673771. Epub 2021 Jul 27.

College of Management, Sichuan Agricultural University, Chengdu, China.

The emergence of coronavirus disease 2019 (COVID-19) has considerably changed global food production, processing, and consumption at different levels. Sojourners are among those who have experienced a higher level of food insecurity during the crisis of the COVID-19 outbreak. The current research aimed to investigate the immediate consumption behavioral intentions of the Pakistani international students in the Peoples Republic of China (PRC) during the wake of COVID-19 pandemic. This study applied the Theory of Planned Behavior (TPB) and background factors of food safety and health consciousness that influence the consumption behavioral intention of Pakistani students toward unfamiliar local food in China. A relational model was analyzed where food safety and health consciousness were hypothesized to serve as background variables associated with TPB components. Moreover, the indirect effects of food safety and health consciousness on behavioral intentions were assessed. The data were collected through convenience samples from 462 Pakistani international students and were analyzed through partial least square structural equation modeling (PLS-SEM). The results confirmed that food safety and health consciousness were positively associated with attitude (ATT), subjective norm (SN), and perceived behavioral control (PBC). However, food safety and health consciousness were indirectly associated with the behavioral intention only through ATT and SN. The results highlighted the role of food safety and health consciousness as important antecedents of classical TPB components that affect intentions and behaviors to avoid unfamiliar local food in a migrated context. The present study provides enlightenment to those who aim to investigate the consumption behavioral intentions of sojourners in the wake of the pandemic situation based on food safety and health consciousness. The findings of the current study are also applicable to general consumption patterns in the food sector.
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http://dx.doi.org/10.3389/fpsyg.2021.673771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353093PMC
July 2021

Global detection of DNA repair outcomes induced by CRISPR-Cas9.

Nucleic Acids Res 2021 09;49(15):8732-8742

The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Center for Life Sciences, Genome Editing Research Center, Peking University, Beijing 100871, China.

CRISPR-Cas9 generates double-stranded DNA breaks (DSBs) to activate cellular DNA repair pathways for genome editing. The repair of DSBs leads to small insertions or deletions (indels) and other complex byproducts, including large deletions and chromosomal translocations. Indels are well understood to disrupt target genes, while the other deleterious byproducts remain elusive. We developed a new in silico analysis pipeline for the previously described primer-extension-mediated sequencing assay to comprehensively characterize CRISPR-Cas9-induced DSB repair outcomes in human or mouse cells. We identified tremendous deleterious DSB repair byproducts of CRISPR-Cas9 editing, including large deletions, vector integrations, and chromosomal translocations. We further elucidated the important roles of microhomology, chromosomal interaction, recurrent DSBs, and DSB repair pathways in the generation of these byproducts. Our findings provide an extra dimension for genome editing safety besides off-targets. And caution should be exercised to avoid not only off-target damages but also deleterious DSB repair byproducts during genome editing.
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http://dx.doi.org/10.1093/nar/gkab686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421148PMC
September 2021

Preparation of V-type cold water-swelling starch by ethanolic extrusion.

Carbohydr Polym 2021 Nov 3;271:118400. Epub 2021 Jul 3.

State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, PR China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, PR China. Electronic address:

Ethanolic extrusion was used to prepare V-type cold water-swelling starch (VCWSS). Effects of extrusion temperature, ratio of starch to ethanol, and ratio of starch to water on the properties of VCWSS were investigated. It was found that when the extrusion temperature was 100 °C, the ratio of starch to ethanol was 1:0.30, and the ratio of starch to water was 1:0.60, the resulting VCWSS could quickly swell into paste in cold water with the highest V-type relative crystallinity (12.90%) and cold paste viscosity (3058 cP). Then the formation mechanism of cold paste viscosity of VCWSS was evaluated. The cold paste viscosity of VCWSS was positively related to its V-type relative crystallinity. Extrusion destroyed the granular morphology of native starch, and VCWSS particles exhibited rock-like morphology that is much larger than the granules of native starch. Formation of the V-amylose-ethanol complex during extrusion was the direct cause of rapid hydration of VCWSS.
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http://dx.doi.org/10.1016/j.carbpol.2021.118400DOI Listing
November 2021

MeCP2 prevents age-associated cognitive decline via restoring synaptic plasticity in a senescence-accelerated mouse model.

Aging Cell 2021 09 7;20(9):e13451. Epub 2021 Aug 7.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School of Xuzhou Medical University, Xuzhou, China.

Age-related cognitive decline in neurodegenerative diseases, such as Alzheimer's disease (AD), is associated with the deficits of synaptic plasticity. Therefore, exploring promising targets to enhance synaptic plasticity in neurodegenerative disorders is crucial. It has been demonstrated that methyl-CpG binding protein 2 (MeCP2) plays a vital role in neuronal development and MeCP2 malfunction causes various neurodevelopmental disorders. However, the role of MeCP2 in neurodegenerative diseases has been less reported. In the study, we found that MeCP2 expression in the hippocampus was reduced in the hippocampus of senescence-accelerated mice P8 (SAMP8) mice. Overexpression of hippocampal MeCP2 could elevate synaptic plasticity and cognitive function in SAMP8 mice, while knockdown of MeCP2 impaired synaptic plasticity and cognitive function in senescence accelerated-resistant 1 (SAMR1) mice. MeCP2-mediated regulation of synaptic plasticity may be associated with CREB1 pathway. These results suggest that MeCP2 plays a vital role in age-related cognitive decline by regulating synaptic plasticity and indicate that MeCP2 may be promising targets for the treatment of age-related cognitive decline in neurodegenerative diseases.
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http://dx.doi.org/10.1111/acel.13451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441320PMC
September 2021

The Distinct Performances of Ultrasound, Mammograms, and MRI in Detecting Breast Cancer in Patients With Germline Pathogenic Variants in Cancer Predisposition Genes.

Front Oncol 2021 13;11:710156. Epub 2021 Jul 13.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

A proportion of up to 10% of breast cancer resulted from hereditary germline pathogenic variants (GPVs) in cancer predisposition genes (CPGs), which been demonstrated distinct clinical features and imaging manifestations. However, the performance of imaging modalities for breast cancer surveillance in CPG mutation-carriers is still unclear, especially in Asian women. A population of 3002 breast cancer patients who received germline genetic testing of CPGs was enrolled from three hospitals in China. In total, 343 (11.6%) patients were found to harbor GPVs in CPGs, including 137 (4.6%) in and 135 (4.6%) in . We compared the performances of ultrasound, mammograms, MRI, and the combining strategies in CPG mutation carriers and non-carriers. As a result, the ultrasound showed a higher detection rate compared with mammograms regardless of the mutation status. However, its detection rate was lower in CPG mutation carriers than in non-carriers (93.2% 98.0%, =2.1×10), especially in the mutation carriers (90.9% 98.0%, =2.0×10). MRI presented the highest sensitivity (98.5%) and the lowest underestimation rate (14.5%) in CPG mutation carriers among ultrasound, mammograms, and their combination. Supplemental ultrasound or mammograms would add no significant value to MRI for detecting breast cancer (>0.05). In multivariate logistic regression analysis, the family or personal cancer history could not replace the mutation status as the impact factor for the false-negative result and underestimation. In summary, clinicians and radiologists should be aware of the atypical imaging presentation of breast cancer in patients with GPVs in CPGs.
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http://dx.doi.org/10.3389/fonc.2021.710156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316045PMC
July 2021

p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy.

Front Immunol 2021 14;12:685523. Epub 2021 Jul 14.

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Recent studies have shown that autophagy upregulation can attenuate sepsis-induced acute kidney injury (SAKI). The tumor suppressor p53 has emerged as an autophagy regulator in various forms of acute kidney injury (AKI). Our previous studies showed that p53 acetylation exacerbated hemorrhagic shock-induced AKI and lipopolysaccharide (LPS)-induced endothelial barrier dysfunction. However, the role of p53-regulated autophagy in SAKI has not been examined and requires clarification. In this study, we observed the dynamic changes of autophagy in renal tubular epithelial cells (RTECs) and verified the protective effects of autophagy activation on SAKI. We also examined the changes in the protein expression, intracellular distribution (nuclear and cytoplasmic), and acetylation/deacetylation levels of p53 during SAKI following cecal ligation and puncture (CLP) or LPS treatment in mice and in a LPS-challenged human RTEC cell line (HK-2 cells). After sepsis stimulation, the autophagy levels of RTECs increased temporarily, followed by a sharp decrease. Autophagy inhibition was accompanied by an increased renal tubular injury score. By contrast, autophagy agonists could reduce renal tubular damage following sepsis. Surprisingly, the expression of p53 protein in both the renal cortex and HK-2 cells did not significantly change following sepsis stimulation. However, the translocation of p53 from the nucleus to the cytoplasm increased, and the acetylation of p53 was enhanced. In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI. In addition, we found that acetylated p53 was easier to bind with Beclin1 and accelerated its ubiquitination-mediated degradation. Our study underscores the importance of deacetylated p53-mediated RTEC autophagy in future SAKI treatments.
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http://dx.doi.org/10.3389/fimmu.2021.685523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318785PMC
July 2021

Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.

Nutr Cancer 2021 Aug 2:1-12. Epub 2021 Aug 2.

College of Public Health and, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Esophageal squamous cell carcinoma is a malignant tumor that is difficult to find and has a poor prognosis. The aim of this study is to explore the chemoprevention effect of Astaxanthin (AST) and reveal the possible mechanism of AST on the development of esophageal cancer based on PPARγ. We found that a stable and strong binding between PPARγ molecules and AST molecules using Autodock 4.0 software. AST significantly inhibited the viability of EC109 cells in a dose and time dependent manners (all  < 0.05), and up-regulated the protein expression level of PPARγ from the concentration of 6.25 µM ( < 0.05). Animal experiment showed that AST significantly decreased the incidences of NMBzA-induced esophageal carcinogenesis at 50 mg/kg AST in F344 rats ( < 0.05). AST inhibited the oxidative stress by improving the levels of superoxide dismutase (SOD), total antioxidant capacity (TAOC) and suppressing malondialdehyde (MDA) in serum, and increasing the protein of PPARγ, Bax/Bcl-2, Caspase-3 in esophagus tissue, especially in the 50 mg/kg of AST intervention group (all  < 0.05). In conclusion, our data suggested that protective effect of AST on esophageal cancer by inhibiting oxidative stress, up-regulating PPARγ, and activating the apoptotic pathway, which could provide a basis for clinical application of AST.
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http://dx.doi.org/10.1080/01635581.2021.1952449DOI Listing
August 2021

A Novel Nomogram Based on Hepatic and Coagulation Function for Evaluating Outcomes of Intrahepatic Cholangiocarcinoma After Curative Hepatectomy: A Multi-Center Study of 653 Patients.

Front Oncol 2021 12;11:711061. Epub 2021 Jul 12.

Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.

Background And Aims: Hepatic and coagulation function are routine laboratory tests prior to curative hepatectomy. The prognostic value of gamma-glutamyl transpeptidase (GGT) to platelet ratio (GPR) and international normalized ratio (INR) in surgically treated patients with intrahepatic cholangiocarcinoma (ICC) remains unclear.

Methods: ICC patients received curative hepatectomy in two west China centers were included. Time-dependent ROC curves were conducted to compare established indexes with prognostic value for ICC. GPR-INR score was introduced and evaluated using the Time-dependent AUC curve and Kaplan-Meier survival analysis. A novel nomogram based on the GPR-INR score was proposed; Harrell's C-index, calibration curve and decision curve analysis were used to assess this nomogram.

Results: A total of 653 patients were included. The areas under ROC curves of GPR and INR in OS and RFS were superior to other indexes. Patients with a high GPR-INR score (1,2) presented significantly decreased overall survival (OS) and recurrence-free survival (RFS); GPR-INR sore, along with several clinicopathological indexes were selected into the nomogram, the calibration curve for OS probability showed good coincidence between the nomogram and the actual surveillance. The C-index of the nomogram was 0.708 (derivation set) and 0.746 (validation set), which was more representative than the C-indexes of the GPR-INR score (0.597, 0.678). In decision curve analysis, the net benefits of the nomogram in derivation and validation set were higher than Barcelona Clinic Liver Cancer staging (BCLC) classification and American Joint Committee on Cancer (AJCC) TNM 8 staging system.

Conclusions: The proposed nomogram generated superior discriminative ability to established staging systems; it is profitable to applicate this nomogram in clinical practice.
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http://dx.doi.org/10.3389/fonc.2021.711061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311735PMC
July 2021

One-dimensional Ag-CoNi nanocomposites modified with amorphous Sn(OH)/SnO shells for broadband microwave absorption.

J Colloid Interface Sci 2021 Dec 7;604:616-623. Epub 2021 Jul 7.

School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, PR China; MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Condition, Ministry of Education, Northwestern Polytechnical University, Xi'an 710072, PR China.

High-performance microwave absorption absorbers play important roles in the fields of radar stealth, electromagnetic protection, and antenna technology. In this work, high aspect-ratio Ag nanowires were decorated with magnetic CoNi nanoparticles via a PVP-induced solvothermal method, and then amorphous Sn(OH)/SnO shells were introduced through an in-situ oxidative hydrolysis method, successfully preparing [email protected](OH)/SnO composites. The morphology and ingredient of composites were ascertained by SEM, TEM, XRD, EDX, and XPS. As Ag-CoNi nanocomposites are coated by Sn(OH)/SnO shells, the minimum reflection loss value is decreased from -31.7 dB (10.1 GHz) to -37.8 dB (6.4 GHz), and the maximum effective absorption bandwidth is extended from 3.9 GHz (10.3-14.2 GHz) to 5.8 GHz (10.7-16.5 GHz). Analyses of electromagnetic parameters reveal the possible mechanisms, involving surface plasma resonance, conductive loss, interfacial polarization, dipole polarization, exchange resonance, eddy current effect, multiple reflection and scattering. Thus, Ag nanowires modified with CoNi nanoparticles and amorphous Sn(OH)/SnO shells can effectively balance the impedance matching and attenuation capability. It is a new strategy to achieve broadband microwave absorbers.
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http://dx.doi.org/10.1016/j.jcis.2021.07.017DOI Listing
December 2021

Enhancing Lithium-Storage Performance via Graphdiyne/Graphene Interface by Self-Supporting Framework Synthesized.

ACS Appl Mater Interfaces 2021 Jul 19;13(29):34332-34340. Epub 2021 Jul 19.

Fujian Provincial Industry Technologies Development Base for New Energy, College of Energy, Xiamen University, Xiamen 361102, P. R. China.

The self-supporting graphdiyne/exfoliated graphene (GDY/EG) composites materials were prepared by the solvothermal method and applied as lithium-ion batteries (LIBs). Graphdiyne (GDY) is a new type of carbon allotrope with a natural macroporous structure, but its conductivity is poor. A small amount of highly conductive graphene can improve surface conductivity and facilitate electron transport. The layered GDY/graphene heterogeneous interface can reduce the electron aggregation polarization, enhance the ability to obtain electrons from the electrolyte, and form a more uniform solid-electrolyte interface (SEI) film. The structural performance and electrochemical performance have been systematically studied. The results showed that the GDY/EG composite electrode has a reversible capacity of 1253 mA h g after 600 cycles at a current density of 0.5 A g. When the current density is 5 A g, the GDY/EG composite electrode can still maintain a reversible capacity of 324 mA h g after 2000 cycles, and the electrode can still maintain a good morphology after recycling. GDY/EG has a high reversible capacity, excellent rate capability, and cycle stability. A small amount of EG and inner foam copper form a double-layer conductivity, which changes the storage method of lithium ions and facilitates the rapid diffusion of lithium ions.
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http://dx.doi.org/10.1021/acsami.1c08164DOI Listing
July 2021
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