Publications by authors named "Jiawei Zhu"

65 Publications

Joint toxicity of lead and cadmium on the behavior of zebrafish larvae: An antagonism.

Aquat Toxicol 2021 Jul 16;238:105912. Epub 2021 Jul 16.

Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Although the individual toxicity of lead (Pb) and cadmium (Cd) was intensively studied, little is known about their joint toxicity on the development of circadian behavioral rhythm. Therefore, we co-exposed zebrafish to Pb and Cd to investigate the alterations of behavioral rhythm and the potential mechanism. Inductively coupled plasma mass spectrometry analysis was used to detect the internal exposure level of heavy metals. The behavioral rhythm was monitored by a video-track tracking system. The changes of gene expression regarding melatonin-related molecules and clock genes were analyzed by quantitative polymerase chain reaction and JTK-Cycle analysis. The results showed that the level of Pb and Cd accumulated in the co-exposure group were significantly lower than that in the Pb or Cd group. Exposed to Pb reduced the locomotor activity; the behavioral rhythms were disrupted by Cd, while the pattern in the co-exposure group showed an antagonistic effect on locomotor activity and behavioral rhythm. The expression rhythm of aanat1 was disturbed and the expression levels of mtnr1aa and mtnr1bb were decreased by co-exposure treatment, but mtnr1c was increased in Pb and Cd group, respectively. Exposure to Cd caused the disruption of expression rhythm in clock genes, like clock1b, clock2, and cry1b, while only the rhythm of clock2 was disrupted in the co-exposure group. The results suggest that the behavioral rhythm disruption caused by Cd exposure is associated with the disturbance of certain circadian genes, whereas Pb exposure only abates the locomotor activity; an antagonistic effect on the behavioral pattern when co-exposed zebrafish larvae to Pb and Cd.
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http://dx.doi.org/10.1016/j.aquatox.2021.105912DOI Listing
July 2021

Active site engineering of atomically dispersed transition metal-heteroatom-carbon catalysts for oxygen reduction.

Chem Commun (Camb) 2021 Jul 21. Epub 2021 Jul 21.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China. and Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Xianhu Hydrogen Valley, Foshan 528200, P. R. China.

Owing to the advantage of atomic utilization, the single-atom catalyst has attracted much attention and been employed in multifarious catalytic reactions. Its definite site configuration is favorable for exploring the actual active centers and corresponding reaction mechanism. At the atomic scale, the tunable site configuration, from central metal atoms, coordinated heteroatoms, peripheral dopants, and feasible polymetallic centers to the synergetic intrinsic carbon defects, can effectively augment the intrinsic activity for oxygen reduction reaction (ORR). From a practical viewpoint, the propagation strategies of single-atom sites, the loading-activity relation and the structural retention during practical tests are crucial for the industrial applications. Furthermore, the activity contribution of multiple additional active centers including the active carbon sites and the pony-size well-wrapped metal species should be acknowledged. From the perspective mentioned above, this paper thoroughly analyses the consensuses, controversies, challenges and possible solutions based on the current research progress, thereby providing inspiration and guidance for the active center engineering of single-atom catalysts.
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http://dx.doi.org/10.1039/d1cc03076kDOI Listing
July 2021

Defect and Doping Co-Engineered Non-Metal Nanocarbon ORR Electrocatalyst.

Nanomicro Lett 2021 Feb 6;13(1):65. Epub 2021 Feb 6.

Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.

Exploring low-cost and earth-abundant oxygen reduction reaction (ORR) electrocatalyst is essential for fuel cells and metal-air batteries. Among them, non-metal nanocarbon with multiple advantages of low cost, abundance, high conductivity, good durability, and competitive activity has attracted intense interest in recent years. The enhanced ORR activities of the nanocarbons are normally thought to originate from heteroatom (e.g., N, B, P, or S) doping or various induced defects. However, in practice, carbon-based materials usually contain both dopants and defects. In this regard, in terms of the co-engineering of heteroatom doping and defect inducing, we present an overview of recent advances in developing non-metal carbon-based electrocatalysts for the ORR. The characteristics, ORR performance, and the related mechanism of these functionalized nanocarbons by heteroatom doping, defect inducing, and in particular their synergistic promotion effect are emphatically analyzed and discussed. Finally, the current issues and perspectives in developing carbon-based electrocatalysts from both of heteroatom doping and defect engineering are proposed. This review will be beneficial for the rational design and manufacturing of highly efficient carbon-based materials for electrocatalysis.
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http://dx.doi.org/10.1007/s40820-020-00579-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187682PMC
February 2021

Anion Modulation of Pt-Group Metals and Electrocatalysis Applications.

Chemistry 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, P. R. China.

Pt-group metal (PGM) electrocatalysts with unique electronic structures and irreplaceable comprehensive properties play crucial roles in electrocatalysis. Anion engineering can create a series of PGM compounds (such as RuP , IrP , PtP , RuB , Ru B , RuS , etc.) that provide a promising prospect for improving the electrocatalytic performance and use of Pt-group noble metals. This review seeks the electrochemical activity origin of anion-modulated PGM compounds, and systematically analyzes and summarizes their synthetic strategies and energy-relevant applications in electrocatalysis. Orientation towards the sustainable development of nonfossil resources has stimulated a blossoming interest in the design of advanced electrocatalysts for clean energy conversion. The anion-modulated strategy for Pt-group metals (PGMs) by means of anion engineering possesses high flexibility to regulate the electronic structure, providing a promising prospect for constructing electrocatalysts with superior activity and stability to satisfy a future green electrochemical energy conversion system. Based on the previous work of our group and others, this review summarizes the up-to-date progress on anion-modulated PGM compounds (such as RuP , IrP , PtP , RuB , Ru B , RuS , etc.) in energy-related electrocatalysis from the origin of their activity and synthetic strategies to electrochemical applications including hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), hydrogen oxidation reaction (HOR), N reduction reaction (NRR), and CO reduction reaction (CO RR). At the end, the key problems, countermeasures and future development orientations of anion-modulated PGM compounds toward electrocatalytic applications are proposed.
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http://dx.doi.org/10.1002/chem.202101645DOI Listing
June 2021

Comparative characterization of lipids and volatile compounds of Beijing Heiliu and Laiwu Chinese black pork as markers.

Food Res Int 2021 08 24;146:110433. Epub 2021 May 24.

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

Chinese black pork is preferred by consumers due to its unique organoleptic characteristics, which are closely related to lipids and volatiles. The primary aim of this study was to reveal key lipids and volatiles for the differentiation of Duroc × (Landrace × Yorkshire) (DLY), and Beijing Heiliu and Laiwu black (BHLB) pork. Here, lipid and volatile profiles were comprehensively characterized and compared using untargeted lipidomic and volatilomic analysis. The BHLB pork showed higher intramuscular fat content (p < 0.05). The content of total monounsaturated fatty acids, along with C16:1, C17:1, C18:1, and C20:1, was higher in BHLB pork compared with DLY pork (p < 0.05). Lipidomic analysis showed that DLY and BHLB pork significantly differed in lipids at the class and molecular levels. The BHLB pork had significantly more triglyceride and less lysophosphatidylcholine compared with DLY pork (p < 0.05). In positive and negative modes, 34 and 21 potential lipid markers, respectively, were selected for the discrimination of DLY and BHLB pork. In addition, volatilomic analysis showed that DLY and BHLB pork were well distinguished, and 13 volatiles were considered as potential discriminatory markers. Our findings provide a comprehensive lipidomic and volatilomic profiles characteristic of BHLB pork and will hopefully provide an important basis for the effective identification of Chinese black pork.
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http://dx.doi.org/10.1016/j.foodres.2021.110433DOI Listing
August 2021

Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway.

Int Immunopharmacol 2021 Jul 15;96:107771. Epub 2021 May 15.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, PR China. Electronic address:

B-cell activating factor (BAFF) is an essential cytokine for B-cell maturation, differentiation and survival, and excess BAFF induces aggressive or neoplastic B-cell disorders and contributes to development of autoimmune diseases. Metformin, an anti-diabetic drug, has recently garnered a great attention due to its anti-proliferative and immune-modulatory features. However, little is known regarding the effect of metformin on BAFF-stimulated B cells. Here, we show that metformin attenuated human soluble BAFF (hsBAFF)-induced cell proliferation and survival by blocking the Erk1/2 pathway in normal and B-lymphoid (Raji) cells. Pretreatment with U0126, knockdown of Erk1/2, or expression of dominant negative MKK1 strengthened metformin's inhibition of hsBAFF-activated Erk1/2 and B-cell proliferation/viability, whereas expression of constitutively active MKK1 rendered high resistance to metformin. Further investigation found that overexpression of wild type PTEN or ectopic expression of dominant negative Akt potentiated metformin's suppression of hsBAFF-induced Erk1/2 activation and proliferation/viability in Raji cells, implying a PTEN/Akt-dependent mechanism involved. Furthermore, we noticed that metformin hindered hsBAFF-activated mTOR pathway in B cells. Inhibition of mTOR with rapamycin or knockdown of mTOR enhanced metformin's suppression of hsBAFF-induced phosphorylation of S6K1, PTEN, Akt, and Erk1/2, as well as B-cell proliferation/viability. These results indicate that metformin prevents BAFF activation of Erk1/2 from cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway in normal and neoplastic B-lymphoid cells. Our findings support that metformin has a great potential for prevention of excessive BAFF-induced aggressive B-cell malignancies and autoimmune diseases.
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http://dx.doi.org/10.1016/j.intimp.2021.107771DOI Listing
July 2021

Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression, evoking oxidative stress, and activating inflammation and apoptosis.

J Anim Sci Biotechnol 2021 May 17;12(1):65. Epub 2021 May 17.

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Background: The immune system is one aspect of health that is affected by dietary selenium (Se) levels and selenoprotein expression. Spleen is an important immune organ of the body, which is directly involved in cellular immunity. However, there are limited reports on Se levels and spleen health. Therefore, this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic pathogenesis.

Methods: Twenty-four pure line castrated male Yorkshire pigs (45 days old, 12.50 ± 1.32 kg, 12 full-sibling pairs) were divided into two equal groups and fed Se-deficient diet (0.007 mg Se/kg) or Se-adequate diet (0.3 mg Se/kg) for 16 weeks. At the end of the trial, blood and spleen were collected to assay for erythroid parameters, the osmotic fragility of erythrocytes, the spleen index, histology, terminal deoxynucleotidyl transferase nick-end labeling (TUNEL) staining, Se concentrations, the selenogenome, redox status, and signaling related inflammation and apoptosis.

Results: Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes (P < 0.05). The spleen index did not change, but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased, the red pulp increased, and splenocyte apoptosis occurred in the Se deficient group. Se deficiency decreased the Se concentration and selenoprotein expression in the spleen (P < 0.05), blocked the glutathione and thioredoxin antioxidant systems, and led to redox imbalance. Se deficiency activated the NF-κB and HIF-1α transcription factors, thus increasing pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, and TNF-α), decreasing anti-inflammatory cytokines (IL-10, IL-13, and TGF-β) and increasing expression of the downstream genes COX-2 and iNOS (P < 0.05), which in turn induced inflammation. In addition, Se-deficiency induced apoptosis through the mitochondrial pathway, upregulated apoptotic genes (Caspase3, Caspase8, and Bak), and downregulated antiapoptotic genes (Bcl-2) (P < 0.05) at the mRNA level, thus verifying the results of TUNEL staining.

Conclusions: These results indicated that Se deficiency induces spleen injury through the regulation of selenoproteins, oxidative stress, inflammation and apoptosis.
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http://dx.doi.org/10.1186/s40104-021-00587-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127211PMC
May 2021

A Fluorescent Probe for the Specific Staining of Cysteine Containing Proteins and Thioredoxin Reductase in SDS-PAGE.

Biosensors (Basel) 2021 Apr 23;11(5). Epub 2021 Apr 23.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

A naphthalimide-based fluorescent probe, Nap-I, with iodoacetamide as the alkylating group, has been synthesized, and its specific fluorescent staining of proteins containing cysteine (Cys) and selenocysteine (Sec) residues in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) has been evaluated. This molecule shows good fluorescence properties in the labeling of protein Cys/Sec residues, while reducing steric hindrance and minimizing changes in the water solubility of proteins. Reaction parameters, such as labeling time and pH, have been investigated, and the optimal labeling conditions for Cys-containing proteins have been determined. Thioredoxin reductase (TXNRD) is best stained at low pH. The probe Nap-I has been successfully used for the quantification of serum proteins and hemoglobin in Tan sheep serum, and TXNRD in Tan sheep liver and muscle has been labeled at low pH. Based on the probe Nap-I, we have also distinguished TXNRD1 and TXNRD2 by SDS-PAGE. The results showed that, compared with the normal microenvironment in which the protein resides, the lower the pH value, the greater the TXNRD activity.
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http://dx.doi.org/10.3390/bios11050132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146322PMC
April 2021

Effects of Chinese medical pricing reform on the structure of hospital revenue and healthcare expenditure in county hospital: an interrupted time series analysis.

BMC Health Serv Res 2021 Apr 26;21(1):385. Epub 2021 Apr 26.

School of Health Management, Southern Medical University, No.1023 Shatai Road, 510515, Guangzhou, China.

Background: China has initiated a medical pricing reform to combat the overuse of drugs and relieve the financial burden of patients. This paper aims to analyze the effect of medical pricing reform on revenue structure and healthcare expenditure of county public hospitals in Guangdong province.

Methods: Based on the monthly data from January 2013 to August 2019, we use interrupted time series design to evaluate the effects of medical pricing reform on healthcare expenditure in both outpatients and inpatients. A counterfactual is also established to examine the net effect of the policy.

Results: The proportion of drug revenue decreased from 35 % to 2015 to 29.7 % in 2019, and the revenue from medical services and inspection increased 3.2 and 3 % respectively. Meanwhile, the increasing trend of total expenditure and its main components is slowed down, especially the drug expense and medical consumable expense for inpatients after the Zero Mark-up Drug policy (coefficient = -18.76, p < 0.01; coefficient = -13.41, p < 0.01, respectively). However, the growth of inspection expense for outpatients continues to increase, while the healthcare expenditure for inpatients experiences an instant increase after the Zero Mark-up Medical Consumables policy. In terms of the net effect, most of healthcare expenditure in both outpatient and inpatient experienced a negative net growth from 2015 to 2019.

Conclusions: The medical pricing reform is a valuable attempt in controlling the unreasonable increase of medical expenses. In the meantime, the unexpected increase in inspection expenditure and insufficient compensation from medical service adjustment should draw the attention of the policymakers.
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http://dx.doi.org/10.1186/s12913-021-06388-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077778PMC
April 2021

Identification of Novel Mutations in : Expanding the Mutational Spectrum for Female Infertility.

Front Cell Dev Biol 2021 9;9:647130. Epub 2021 Apr 9.

Institute of Pediatrics, Children's Hospital of Fudan University and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.

Oocyte maturation and fertilization are fundamental processes for successful human reproduction, and abnormalities in these processes will cause infertility. Recently, we identified biallelic mutations in that are responsible for human oocyte maturation arrest, fertilization failure, and early embryonic development arrest. In this study, we screened for further mutations in a new cohort of patients with abnormalities in oocyte maturation, fertilization, and early embryonic development. Through whole-exome sequencing, we identified the four novel mutations c.887G > A (p. Arg296Gln), c.964C > T (p.Arg322), c.1155G > C (p.Trp385Cys), and c.330 + 1G > A (p. Glu111Ilefs36) and one previously reported mutation c.965G > A (p.Arg322Gln) in in four infertile individuals from three independent families. The patients had different phenotypes of oocyte maturation arrest and fertilization failure resulting from the different mutations. This study confirms our previous research and expands the spectrum of known mutations in , providing new evidence supporting the function of in the genetic etiology of female infertility characterized by oocyte maturation arrest and fertilization failure.
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http://dx.doi.org/10.3389/fcell.2021.647130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063106PMC
April 2021

Regulating Fe-spin state by atomically dispersed Mn-N in Fe-N-C catalysts with high oxygen reduction activity.

Nat Commun 2021 Mar 19;12(1):1734. Epub 2021 Mar 19.

College of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450001, PR China.

As low-cost electrocatalysts for oxygen reduction reaction applied to fuel cells and metal-air batteries, atomic-dispersed transition metal-nitrogen-carbon materials are emerging, but the genuine mechanism thereof is still arguable. Herein, by rational design and synthesis of dual-metal atomically dispersed Fe,Mn/N-C catalyst as model object, we unravel that the O reduction preferentially takes place on Fe in the FeN /C system with intermediate spin state which possesses one e electron (t4e1) readily penetrating the antibonding π-orbital of oxygen. Both magnetic measurements and theoretical calculation reveal that the adjacent atomically dispersed Mn-N moieties can effectively activate the Fe sites by both spin-state transition and electronic modulation, rendering the excellent ORR performances of Fe,Mn/N-C in both alkaline and acidic media (halfwave positionals are 0.928 V in 0.1 M KOH, and 0.804 V in 0.1 M HClO), and good durability, which outperforms and has almost the same activity of commercial Pt/C, respectively. In addition, it presents a superior power density of 160.8 mW cm and long-term durability in reversible zinc-air batteries. The work brings new insight into the oxygen reduction reaction process on the metal-nitrogen-carbon active sites, undoubtedly leading the exploration towards high effective low-cost non-precious catalysts.
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http://dx.doi.org/10.1038/s41467-021-21919-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979714PMC
March 2021

Two-Dimensional MoS: Structural Properties, Synthesis Methods, and Regulation Strategies toward Oxygen Reduction.

Micromachines (Basel) 2021 Feb 27;12(3). Epub 2021 Feb 27.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.

Compared with three-dimensional (3D) and other materials, two-dimensional (2D) materials with unique properties such as high specific surface area, structurally adjustable band structure, and electromagnetic properties have attracted wide attention. In recent years, great progress has been made for 2D MoS in the field of electrocatalysis, and its exposed unsaturated edges are considered to be active sites of electrocatalytic reactions. In this review, we focus on the latest progress of 2D MoS in the oxygen reduction reaction (ORR) that has not received much attention. First, the basic properties of 2D MoS and its advantages in the ORR are introduced. Then, the synthesis methods of 2D MoS are summarized, and specific strategies for optimizing the performance of 2D MoS in ORRs, and the challenges and opportunities faced are discussed. Finally, the future of the 2D MoS-based ORR catalysts is explored.
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http://dx.doi.org/10.3390/mi12030240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996743PMC
February 2021

Corrigendum to: Association of polymorphisms in MALAT1 with the risk of endometriosis in Southern Chinese women.

Biol Reprod 2021 04;104(4):935-938

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

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http://dx.doi.org/10.1093/biolre/ioab030DOI Listing
April 2021

Regulative Electronic States around Ruthenium/Ruthenium Disulphide Heterointerfaces for Efficient Water Splitting in Acidic Media.

Angew Chem Int Ed Engl 2021 May 30;60(22):12328-12334. Epub 2021 Mar 30.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, P. R. China.

Theoretical calculations unveil the charge redistribution over abundant interfaces and the enhanced electronic states of Ru/RuS heterostructure. The resulting surface electron-deficient Ru sites display optimized adsorption behavior toward diverse reaction intermediates, thereby reducing the thermodynamic energy barriers. Experimentally, for the first time the laminar Ru/RuS heterostructure is rationally engineered by virtue of the synchronous reduction and sulfurization under eutectic salt system. Impressively, it exhibits extremely high catalytic activity for both OER (201 mV @ 10 mA cm ) and HER (45 mV @ 10 mA cm ) in acidic media due to favorable kinetics and excellent specific activity, consequently leading to a terrific performance in acidic overall water splitting devices (1.501 V @ 10 mA cm ). The in-depth insight into the internal activity origin of interfacial effect could offer precise guidance for the rational establishment of hybrid interfaces.
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http://dx.doi.org/10.1002/anie.202101539DOI Listing
May 2021

Janus Nanocages of Platinum-Group Metals and Their Use as Effective Dual-Electrocatalysts.

Angew Chem Int Ed Engl 2021 Apr 24;60(18):10384-10392. Epub 2021 Mar 24.

The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.

Janus nanocages with distinctive platinum-group metals on the outer and inner surfaces can naturally catalyze at least two different reactions. Here we report a general method based on successive deposition and then selective etching for the facile synthesis of such nanocages. We have fabricated 11 different types of Janus nanocages characterized by a uniform size and well-defined {100} facets, together with porous, ultrathin, asymmetric walls up to 1.6 nm thick. When tested as dual-electrocatalysts toward oxygen reduction and evolution reactions, the Janus nanocages based on Pt and Ir exhibited superior activities depending on the thickness and relative position of the metal layer. Density functional theory studies suggest that the alloy composition and surface structure of the nanocages both play important roles in enhancing the electrocatalytic activities by modulating the stability of key reaction intermediates.
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http://dx.doi.org/10.1002/anie.202102275DOI Listing
April 2021

Monoclinic dibismuth tetraoxide (m-BiO) for piezocatalysis: new use for neglected materials.

Chem Commun (Camb) 2021 Mar 17;57(22):2740-2743. Epub 2021 Feb 17.

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CIC-AEET), School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing 210044, China.

Piezocatalysis is a promising approach for environmental pollutant removal. Monoclinic dibismuth tetraoxide (m-BiO) was first applied to piezocatalyze organics under ultrasonic vibration. The built-in electric field with ultrasonic stress drives the separation of holes and electrons in m-BiO. Its excellent piezocatalytic activity, reusability and chemical stability make m-BiO a new candidate of piezocatalysis.
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http://dx.doi.org/10.1039/d0cc07064eDOI Listing
March 2021

Atomic Crystal Facet Engineering of Core-Shell Nanotetrahedrons Restricted under Sub-10 Nanometer Region.

ACS Nano 2021 Mar 15;15(3):5178-5188. Epub 2021 Feb 15.

Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.

Simultaneously engineering the size and surface crystal facets of bimetallic core-shell nanocrystals offers an effective route to not only reduce the extravagance of innermost core metal and maximize the utilization efficiency of shell atoms but also strengthen the core-to-shell interaction ligand and/or strain effects. Herein, we systematically study the architecture transition and crystal facet engineering at the atomic level on the surface of sub-5 nm Pd(111) tetrahedrons (Ths), aimed at embodying how the variations in the local facet and shape of a sub-10 nm core-shell structure affect its surface geometrical properties and electronic structures. Specifically, surface atomic replication is predominant when the shell metal deposits less than five atomic layers, thus forming a series of [email protected] (M = Pt, Ru, and Rh) core-shell Ths enclosed by (111) facets (∼6.8 nm), while over five atomic layers, spontaneous facets tropism of each metal is predominant, where Pt atoms still follow -(111) packing, Ru atoms select -phase stacking, and Rh atoms choose -(100) crystallization, respectively. In particular, Pt atoms take a seamless geometrical transformation from [email protected] Ths into [email protected] truncated octahedrons (TOhs, ∼7.6 nm). As a proof-of-concept application, such sub-10 nm core-shell architectures with Pt skin show a component-dependent relationship toward oxygen reduction reaction (ORR), where the catalytic activity follows the order of [email protected](111) TOhs ( = 0.916 V, 1.632 A mg) > [email protected](111) Ths > Pt black. Meanwhile the Ru skin show a facet-dependent relationship toward acidic hydrogen evolution reaction (HER) where the catalytic activity follows the order of [email protected](111) Ths > [email protected]() Ths > Pd Ths.
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http://dx.doi.org/10.1021/acsnano.0c10376DOI Listing
March 2021

Multishell Nanoparticles with "Linkage Mechanism" for Thermal Responsive Photodynamic and Gas Synergistic Therapy.

Adv Healthc Mater 2021 05 15;10(10):e2002038. Epub 2021 Feb 15.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, 211800, China.

The strategies of combining photodynamic therapy (PDT) with other therapeutics are considered to be the most suitable methods in improving the antitumor therapeutic efficiency. Herein, a "Linkage Mechanism" strategy based on thermal controllable multishell nanoparticles ([email protected] -l-Arg (l-arginine)@PCM (phase-change material)-Ce6 (chiorin e6)) is proposed for combing PDT and NO-based gas therapy. Upon 1060 nm laser irradiation, the PCMs will melt under the photothermal effect induced by CuS and the loaded Ce6 and l-Arg can accurately release from the nanoparticles. Under further 660 nm laser irradiation, the released Ce6 will produce plenty of singlet oxygen ( O ) for PDT, while the generated O can oxidize l-Arg to release NO for the synergy of PDT and gas therapy. The "Linkage Mechanism" can achieve precise release of the payloads under the control of photothermal effect at tumor site, and the chain reaction of PDT and gas therapy overcomes the problem of premature release of gas during transportation. Benefiting from the guidance of fluorescence imaging and second near infrared photoacoustic imaging by Ce6 and CuS, both in vitro and in vivo experiments present effective antitumor efficiencies. The nanoparticles provide new ideas for controllable release of drugs and the synergistic effect of multiple treatments, possessing great application prospects.
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http://dx.doi.org/10.1002/adhm.202002038DOI Listing
May 2021

Visual Vignette.

Endocr Pract 2020 Jul 24;26(7):800. Epub 2020 Nov 24.

Department of Endocrinology, Endocrine Key Laboratory of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, and. Electronic address:

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http://dx.doi.org/10.4158/EP-2019-0471DOI Listing
July 2020

The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study.

J Cancer 2021 1;12(1):264-269. Epub 2021 Jan 1.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.

Base excision repair (BER) acts upon the most important mechanism of the DNA repair system, protecting DNA stability and integrity from the mutagenic and cytotoxic effects. Multiple researches have indicated that single-nucleotide polymorphisms (SNPs) in the BER-related gene may be associated with the susceptibility of ovarian cancer. However, the results are controversial. In this two-center case-control study, 19 potentially functional SNPs in six BER-related genes (, , , , and ) was genotyped in 196 ovarian cancer cases and 272 cancer-free controls. And, their associations with ovarian cancer risk were assessed by unconditional logistic regression analyses. We found that rs8679 and rs293795 polymorphisms were associated with a decreased risk of ovarian cancer under dominant model (adjusted OR=0.39, 95% CI=0.17-0.90, =0.026; and adjusted OR=0.36, 95% CI=0.13-0.99, =0.049, respectively). Stratification analysis demonstrated that this association was more pronounced in the subgroups of lower BMI and patients with early menarche and serous carcinoma. Moreover, rs4796030 AA/AC variant genotypes performed an increased risk of ovarian cancer under recessive model (adjusted OR=1.54, 95% CI=1.01-2.35, =0.046), especially in the subgroups of higher BMI, early clinic stage and the carcinoma at the left. These results suggested that , and polymorphisms might impact on the risk of ovarian cancer. However, more researches with larger and different ethnic populations are warranted to support our findings.
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http://dx.doi.org/10.7150/jca.49925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738827PMC
January 2021

Selenium supplementation protects against oxidative stress-induced cardiomyocyte cell cycle arrest through activation of PI3K/AKT.

Metallomics 2020 12;12(12):1965-1978

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Oxidative stress significantly contributes to heart disease, and thus might be a promising target for ameliorating heart failure. Mounting evidence suggests that selenium has chemotherapeutic potential for treating heart disease due to its regulation of selenoproteins, which play antioxidant regulatory roles. Oxidative stress-induced cardiomyocyte cell cycle arrest contributes to the loss of cardiomyocytes during heart failure. The protective effects and mechanism of selenium against oxidative stress-induced cell cycle arrest in cardiomyocytes warrant further study. H9c2 rat cardiomyoblast cells were treated with hydrogen peroxide in the presence or absence of selenium supplementation. Na2SeO3 pretreatment alleviated H2O2-induced oxidative stress, increased thioredoxin reductase (TXNRD) activity and glutathione peroxidase (GPx) activity and counteracted the H2O2-induced cell cycle arrest at the S phase. These effects were accompanied by attenuation of the H2O2-induced strengthening of the G2/M-phase inhibitory system, including increased mRNA and protein levels of cyclin-dependent kinase 1 (CDK1) and decreased p21 mRNA levels. Notably, Na2SeO3 pretreatment activated the PI3K/AKT signaling pathway, and inhibition of PI3K counteracted the protective effects of selenium on H2O2-induced cell cycle arrest. We corroborated our findings in vivo by inducing oxidative stress in pig heart by feeding a selenium deficient diet, which decreased the TXNRD activity, inactivated PI3K/AKT signaling and strengthened the G2/M-phase inhibitory system. We concluded that the cardioprotective effects of selenium supplementation against oxidative stress-induced cell cycle arrest in cardiomyocytes might be mediated by the selenoprotein-associated (GPx and TXNRD) antioxidant capacity, thereby activating redox status-associated PI3K/AKT pathways, which promote cell cycle progression by targeting the G2/M phase inhibitory system. This study provides new insight into the underlying mechanisms of cardioprotection effects of selenium at the cellular level.
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http://dx.doi.org/10.1039/d0mt00225aDOI Listing
December 2020

Prognostic outcome after second primary lung cancer in patients with previously treated lung cancer by radiotherapy.

J Thorac Dis 2020 Oct;12(10):5376-5386

Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Second primary lung cancer (SPLC) occurs not rarely in recent years. The effect of radiotherapy on SPLC remains unclear. This study aims to explore the survival outcome of SPLC patients with clinical stage T1 lung cancer previously treated with radiotherapy.

Methods: A total of 705 SPLC patients that previously underwent radiotherapy for first primary lung cancer (FPLC) were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2016. Univariate and multivariate Cox regression analyses were performed to find prognostic factors. The survival outcomes were plotted using Kaplan-Meier (KM) method and compared by log-rank test. Additionally, propensity score matching (PSM) analyses were used to compare overall survival (OS) and lung cancer-specific survival (CSS) between radiotherapy and other treatment groups for SPLC.

Results: According to Cox analyses, age >62 years [hazard ratio (HR): 1.48, 95% confidence interval (CI): 1.10-1.99; P=0.010], SPLC tumor size >1 cm (HR: 1.95, 95% CI: 1.51-2.53; P<0.001), and treatments for SPLC as chemotherapy (HR: 1.39, 95% CI: 1.13-1.71; P=0.002), no surgery (HR: 2.00, 95% CI: 1.34-2.98; P=0.001) and no radiotherapy (HR: 1.73, 95% CI: 1.39-2.15; P<0.001) independently indicated worse survival. After PSM, patients treated with radiotherapy for SPLC had significantly better OS and CSS than the none-treatment (OS: P=0.004; CSS: P<0.001), chemotherapy (P<0.001) or radiotherapy plus chemotherapy (OS: P=0.032; CSS: P=0.008) groups, but demonstrated a worse OS than the surgery group (P=0.034).

Conclusions: Surgery may be more beneficial to survival than radiotherapy and chemotherapy and should be considered first if possible. When patients cannot tolerate surgery, radiotherapy can be an effective alternative.
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http://dx.doi.org/10.21037/jtd-20-2024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656431PMC
October 2020

Can virtual reality improve traditional anatomy education programmes? A mixed-methods study on the use of a 3D skull model.

BMC Med Educ 2020 Oct 31;20(1):395. Epub 2020 Oct 31.

Department of Endocrinology, Endocrine Key Laboratory of Ministry of Health, Peking Union Medical College Hospital (PUMCH), Chinese Academe of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.

Background: Realistic, portable, and scalable lectures, cadaveric models, 2D atlases and computer simulations are being combined more frequently for teaching anatomy, which result in major increases in user satisfaction. However, although digital simulations may be more portable, interesting, or motivating than traditional teaching tools, whether they are superior in terms of student learning remain unclear. This paper presents a study in which the educational effectiveness of a virtual reality (VR) skull model is compared with that of cadaveric skulls and atlases. The aim of this study was to compare the results of teaching with VR to results of teaching with traditional teaching methods by administering objective questionnaires and perception surveys.

Methods: A mixed-methods study with 73 medical students was conducted with three different groups, namely, the VR group (N = 25), cadaver group (N = 25) and atlas group (N = 23). Anatomical structures were taught through an introductory lecture and model-based learning. All students completed the pre- and post-intervention tests, which comprised a theory test and an identification test. The theory test consisted of 18 multiple-choice questions, and the identification test consisted of 25 fill-in-the-blank questions.

Results: The participants in all three groups had significantly higher total scores on the post-intervention test than on the pre-intervention test; the post-intervention test score in the VR group was not statistically significantly higher than the post-intervention test score of the other groups (VR: 30 [IQR: 22-33.5], cadaver: 26 [IQR: 20-31.5], atlas: 28[IQR: 20-33]; p > 0.05). The participants in the VR and cadaver groups provided more positive feedback on their learning models than the atlas group (VR: 26 [IQR: 19-30], cadaver: 25 [IQR: 19.5-29.5], atlas: 12 [IQR: 9-20]; p < 0.001).

Conclusions: The skull virtual learning resource (VLR) was equally efficient as the cadaver skull and atlas in teaching anatomy structures. Such a model can aid individuals in understanding complex anatomical structures with a higher level of motivation and tolerable adverse effects.
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http://dx.doi.org/10.1186/s12909-020-02255-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603711PMC
October 2020

Synergistic Coupling of Ni Nanoparticles with Ni C Nanosheets for Highly Efficient Overall Water Splitting.

Small 2020 Sep 6;16(37):e2001642. Epub 2020 Aug 6.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, P. R. China.

Exploring earth-abundant bifunctional electrocatalysts with high efficiency for water electrolysis is extremely demanding and challenging. Herein, density functional theory (DFT) predictions reveal that coupling Ni with Ni C can not only facilitate the oxygen evolution reaction (OER) kinetics, but also optimize the hydrogen adsorption and water adsorption energies. Experimentally, a facile strategy is designed to in situ fabricate Ni C nanosheets on carbon cloth (CC), and simultaneously couple with Ni nanoparticles, resulting in the formation of an integrated heterostructure catalyst (Ni-Ni C/CC). Benefiting from the superior intrinsic activity as well as the abundant active sites, the Ni-Ni C/CC electrode demonstrates excellent bifunctional electrocatalytic activities toward the OER and hydrogen evolution reaction (HER), which are superior to all the documented Ni C-based electrocatalysts in alkaline electrolytes. Specifically, the Ni-Ni C/CC catalyst exhibits the low overpotentials of only 299 mV at the current density of 20 mA cm for the OER and 98 mV at 10 mA cm for the HER in 1 m KOH. Furthermore, the bifunctional Ni-Ni C/CC catalyst can propel water electrolysis with excellent activity and nearly 100% faradic efficiency. This work highlights an easy approach for designing and constructing advanced nickel carbide-based catalysts with high activity based on the theoretical predictions.
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http://dx.doi.org/10.1002/smll.202001642DOI Listing
September 2020

The Alterations of Vaginal Microbiome in HPV16 Infection as Identified by Shotgun Metagenomic Sequencing.

Front Cell Infect Microbiol 2020 23;10:286. Epub 2020 Jun 23.

Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

The association of microbiome imbalance with cancer development is being one of the research hotspots. Persistent HPV infection is a causal event in cervical cancer initiation, but, little is known about the microbiome composition and function in HPV infection. Here we identified the compositional and functional alterations on vaginal samples from 27 HPV16 positive women and 25 age-matched HPV negative controls using shotgun metagenomic sequencing, to provide a comprehensive investigation describing the microbial abundances and enriched metabolic functions in cervicovaginal metagenomes. We further employed qPCR assays to evaluate two selected gene markers of HPV16 infection in an independent validation cohort consisting of 88 HPV16 positive women and 81 controls, and six selected species markers in a subset of validation cohort of 45 HPV16 positive women and 53 controls. We found that the relative abundance of dominant Firmicutes was lower, Actinobacteria, Fusobacteria and viruses phyla were significantly higher in the HPV16-positive group; 77 genera including , and were higher, and 20 genera including and were lower in the HPV16-positive women. Abundance of 12 genes, 17 genera, and 7 species biomarkers showed an excellent predictive power for the HPV16-positive individuals, with 0.861, 0.819, and 0.918, respectively, of the area under the receiver-operating characteristic curve (AUC). We further characterized the microbial function, and revealed that HPV16-positive women were enriched in metabolism and membrane transport, and depleted by glycan biosynthesis and metabolism, and replication and repair. Quantitative PCR measurements validated that one gene marker and three species were significantly enriched in HPV16-positive women. These results highlight a fundamental fact that there are altered composition and function of the vaginal microbiome in HPV16-positive women, suggesting that vaginal dysbiosis may be associated with HPV infection in the female genital tract.
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http://dx.doi.org/10.3389/fcimb.2020.00286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324666PMC
June 2021

Photochemical deposition of amorphous MoS on one-dimensional NaNbO-CdS heterojunction photocatalysts for highly efficient visible-light-driven hydrogen evolution.

Dalton Trans 2020 Jul;49(26):8891-8900

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Engineering Technology Research Center of Environmental Cleaning Materials, Nanjing University of Information Science and Technology, Nanjing, 210044, China.

A novel ternary MoSx-CdS-NaNbO3 (MoSx-CN) photocatalyst was successfully fabricated through a two-step method (hydrothermal synthesis and photo-deposition step). The results demonstrated that CdS nanoparticles and amorphous MoSx uniformly dispersed on one-dimensional (1D) NaNbO3 nanowires, thus forming multi-junctions (CdS-NaNbO3, CdS-MoSx and NaNbO3-MoSx) that could increase the migration efficiency of photo-excited charge carriers. In addition, an abundance of unsaturated sulfur atoms in MoSx led to a strong attraction to H+, thus providing active sites for water splitting. Consequently, the optimized composite sample (MoSx-CN-100) exhibited a hydrogen (H2) evolution efficiency of 2.386 mmol g-1 h-1, which was about 125.58 and 11.93 times that of NaNbO3 and CdS, respectively. Moreover, the ternary photocatalyst also exhibited excellent stability in the long-term hydrogen production process compared with the binary and single samples. Our work provided new insight into the rational design of multi-heterojunction photocatalysts with high efficiency for H2 evolution under visible light irradiation.
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http://dx.doi.org/10.1039/d0dt01290dDOI Listing
July 2020

Effects of ecologically relevant concentrations of cadmium on locomotor activity and microbiota in zebrafish.

Chemosphere 2020 Oct 27;257:127220. Epub 2020 May 27.

Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Cadmium (Cd) is widely spread in the aquatic environment, and its impact on humans and the ecosystem is an important issue in public health. However, its effects on zebrafish microbiota are still poorly understood. In this study, the potential developmental neurotoxicity and microbiota dysbiosis of ecologically relevant concentrations of Cd (0, 1.25, 2.5 and 5 μg/L) was evaluated by waterborne exposure for 7 days. The data showed that exposure to 5 μg/L of Cd significantly decreased survival rates and impaired locomotor activities. Uptake of Cd was enhanced with the increase of the concentration and duration of exposure. High-throughput sequencing analysis revealed a significant change in the richness and diversity of the microbiota of Cd-treated zebrafish. At the phylum level, the abundance of Proteobacteria increased, while that Firmicutes was significantly decreased after exposure to 5 μg/L Cd. At the genus level, there were significant changes in the abundances of several bacteria involved in the regulation of neurodegenerative diseases (Pseudomonas, Ruminococcaceae, Blautia, Bacteroides, Lactobacillus, Lachnospiraceae, and Phascolarctobacterium) in the Cd-treatment groups, as compared to the control group. In addition, the mRNA expression profiles of bdnf and genes involved in serotonin signaling and metabolism were changed in the Cd exposure groups. Together, these data suggest that Cd could be harmful to zebrafish health by inducing the microbiota changes, and the microbiota could serve as a potential target to protect against the adverse effects of Cd toxicity.
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http://dx.doi.org/10.1016/j.chemosphere.2020.127220DOI Listing
October 2020

Efficacy of adjuvant radiotherapy for treatment of adrenocortical carcinoma: a retrospective study and an updated meta-analysis.

Radiat Oncol 2020 May 24;15(1):118. Epub 2020 May 24.

Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academe of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Background: Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Surgical resection is the standard treatment for localized ACC, but the local recurrence remains high. Adjuvant radiation (ART) has been proposed as a means to reduce recurrence rates in ACC after surgery with conflicting results from nonrandomized studies. We performed a retrospective study and a meta-analysis to determine the impact of ART on survival outcomes.

Methods: A retrospective study of the adrenocortical cancer database in Peking Union Medical College was conducted. We selected postoperative ACC patients with or without ART. A meta-analysis is also performed to compare the outcomes between ART and only surgical resection in ACC patients. The obtained data were analyzed using SPSS 23.0 and Stata 15.0 statistical software. Differences between two groups were compared using the log-rank test for retrospective analysis and estimated by calculating the odds ratio (OR) and 95% confidence interval (CI) for meta-analysis.

Results: Of a total of 75 patients available in the database, 12 patients underwent postoperative ART and were matched one to one to patients with only surgical resection. There was no significant difference on overall survival between ART group and control group (log-rank P = 0.149). Locoregional recurrence was diagnosed in 2 of the ART group, and in 4 of the control group (P = 0.64). A total of 238 participants were selected for the meta-analysis, of which 111 and 127 patients underwent ART after surgical resection and only surgical resection, respectively. Overall survival is significantly higher in ART group, with an odds ratio (OR) of 2.41 (95% CI of 1.33, 4.38; P = 0.004). Besides, meta-analysis significantly favored ART for locoregional recurrence-free survival and disease-free survival, with an OR of 4.08 and 2.27, respectively.

Conclusions: Our results show that compared to only surgical resection, ART is an effective postoperative treatment for ACC.
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http://dx.doi.org/10.1186/s13014-020-01533-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245885PMC
May 2020

Common genetic variants in pre-microRNAs are associated with cervical cancer susceptibility in southern Chinese women.

J Cancer 2020 3;11(8):2133-2138. Epub 2020 Feb 3.

Department of Obstetrics and Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.

Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 cervical cancer patients and 445 cancer-free female controls using quantitative polymerase chain reaction with TaqMan probes. To estimate the association between pre-microRNA polymorphisms and the risk of cervical cancer, an unconditional logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI), adjusting for age, menopause, delivery, and abortion. We found that the rs1625579 T > G polymorphism was associated with a significant decrease in cervical cancer risk (TG/GG versus TT: adjusted OR (AOR) = 0.47, 95% CI = 0.27-0.81; TG versus TT: AOR = 0.56, 95% CI = 0.34-0.91). We also observed a significant association between the rs895819 T > C polymorphism and decreased cervical cancer risk (TC/CC versus TT: AOR = 0.65, 95% CI = 0.44-0.96). Stratified analysis further demonstrated that the rs1625579 T > C and rs895819 T > C polymorphisms significantly reduced the risk of cervical cancer susceptibility in patients younger than 49 years, those who experienced fewer abortions, and clinical stage I patients. Moreover, the rs1625579 T > G polymorphism showed protective effects in premenopausal women, squamous cell carcinoma patients, and patients with unclassified types of pathologies; the rs895819 T > C polymorphism was also associated with a decreased risk in patients older than 49 years, menopausal women, and women who had experienced vaginal pregnancies. The rs1625579 T > G and rs895819 T > C polymorphisms may provide protective effects against susceptibility to cervical cancer risk.
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http://dx.doi.org/10.7150/jca.39636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052933PMC
February 2020

Efficient and Stable Photocatalytic Hydrogen Evolution Activity of Multi-Heterojunction Composite Photocatalysts: CdS and NiS Co-modified NaNbO Nanocubes.

Front Chem 2019 21;7:880. Epub 2020 Jan 21.

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Engineering Technology Research Center of Environmental Cleaning Materials, School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China.

In this study, a NaNbO/CdS/NiS ternary composite photocatalyst containing no precious metals was successfully prepared by a simple hydrothermal method. The prepared ternary photocatalyst has a significant improvement in photocatalytic performance of hydrogen production from water splitting under visible light irradiation. The best sample NCN40% hydrogen production rate is 4.698 mmol g h, which is about 24.7 times that of pure CdS sample. In addition, the stability of the composite catalyst in the long-term photocatalytic hydrogen production cycle is also improved. The reason for the enhanced hydrogen production performance may be the optimization of the microstructure of the catalyst and the reduction of photogenerated electron-hole recombination. The construction of multi-heterojunctions (NaNbO-CdS, CdS-NiS, and NaNbO-NiS) helps to reduce the recombination of carriers. Furthermore, the -formed NiS nanoparticles can serve as active sites for hydrogen evolution. All of these factors induced the improved photocatalytic activity of the as-prepared ternary photocatalyst.
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http://dx.doi.org/10.3389/fchem.2019.00880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985095PMC
January 2020
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