Publications by authors named "Jiaqi Hu"

57 Publications

Nitrogen and phosphorus removal in simulated wastewater by two aquatic plants.

Environ Sci Pollut Res Int 2021 Jul 5. Epub 2021 Jul 5.

, Nanhu Park, Gongnong Road 2715, Changchun, 130021, China.

Water pollution control is the focus of environmental pollution control. Ecological water treatment is widely used because of its low cost and landscape effect, and has no pollution. Aquatic plants have attracted wide attention because of their low cost and high level of resource utilization. In order to study the effects of emergent and submerged plants on the removal of different concentrations of wastewater, and the effect of pollutants on plant growth, two common aquatic plants found in Northeast China (Iris ensata Thunb. and Potamogeton malaianus Miq.) were selected. Under static conditions, the removal efficiency of nitrogen and phosphorus in wastewater with different concentrations by two kinds of plants was studied. The results showed that the removal rate of total nitrogen (TN) in medium- and high-pollutant concentration water samples and total phosphorus (TP) in medium- and low-pollutant concentration water with I. ensata reached more than 75%. The removal rate of TN in the medium-pollutant concentration water with P. malaianus reached 71.4%, while the removal efficiency of TN and TP in the low-pollutant concentration water was higher than 80%. In the Nanhu Park Lake samples, I. ensata had the highest removal rates of TN (80.38%) and TP (85.62%). This study shows that both I. ensata and P. malaianus can be used as aquatic plants to restore the water quality of urban lakes. This research provides an important basis for the phytoremediation and treatment of urban domestic wastewater and urban surface water bodies in Northern China.
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http://dx.doi.org/10.1007/s11356-021-15206-5DOI Listing
July 2021

Mesoscale structure development reveals when a silkworm silk is spun.

Nat Commun 2021 06 17;12(1):3711. Epub 2021 Jun 17.

College of Animal Science, Zhejiang University, Hangzhou, China.

Silk fibre mechanical properties are attributed to the development of a multi-scale hierarchical structure during spinning. By careful ex vivo processing of a B. mori silkworm silk solution we arrest the spinning process, freezing-in mesoscale structures corresponding to three distinctive structure development stages; gelation, fibrilization and the consolidation phase identified in this work, a process highlighted by the emergence and extinction of 'water pockets'. These transient water pockets are a manifestation of the interplay between protein dehydration, phase separation and nanofibril assembly, with their removal due to nanofibril coalescence during consolidation. We modeled and validated how post-draw improves mechanical properties and refines a silk's hierarchical structure as a result of consolidation. These insights enable a better understanding of the sequence of events that occur during spinning, ultimately leading us to propose a robust definition of when a silkworm silk is actually 'spun'.
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http://dx.doi.org/10.1038/s41467-021-23960-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211695PMC
June 2021

Efficacy and safety of topical administration of tacrolimus in oral lichen planus: An updated systematic review and meta-analysis of randomized controlled trials.

J Oral Pathol Med 2021 Jun 16. Epub 2021 Jun 16.

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Background: Symptomatic oral lichen planus is a common chronic T-cell-mediated disorder characterized by pain and inflammation. The meta-analysis aimed to compare and evaluate the effects and safety of tacrolimus for treating patients with symptomatic oral lichen planus.

Methods: A comprehensive literature review was performed, including PubMed, the Cochrane Library, Embase, and Web of Science published up to and including December 2020. ClinicalTrials.gov was searched for ongoing trials. There were no restrictions on language or date of publication. Using the Cochrane Collaboration tool, we assessed the risk of bias for randomized controlled trials and estimated the proportion of between-trial heterogeneity.

Results: A total of 9 RCTs evaluating the effects of tacrolimus were included in this study. The results revealed no significant difference in clinical resolution and relapse between tacrolimus and corticosteroids. However, tacrolimus may be more likely to cause mild adverse effects. In particular, clinical resolution was not significantly different between tacrolimus and clobetasol propionate, and between tacrolimus and triamcinolone acetonide, while tacrolimus was more likely to cause adverse effects than triamcinolone acetonide and clobetasol propionate. Moreover, there was no significant difference in pain resolution between tacrolimus and clobetasol. Furthermore, adverse effects were not significantly different between tacrolimus and pimecrolimus.

Conclusions: This systematic review and meta-analysis of 9 clinical trials supported the short-term application of tacrolimus as an effective regimen in OLP patients resistant to other topical and systemic therapies. Furthermore, the adverse effects of tacrolimus were minor and transient and did not affect tacrolimus' continued application.
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http://dx.doi.org/10.1111/jop.13217DOI Listing
June 2021

Identifying key areas of imbalanced supply and demand of ecosystem services at the urban agglomeration scale: A case study of the Fujian Delta in China.

Sci Total Environ 2021 Jun 5;791:148173. Epub 2021 Jun 5.

School of Architecture, Tianjin University, Tianjin 300072, China.

The coordinated supply and demand of ecosystem services (ESs) is important for ensuring regional sustainable development. However, research identifying key areas of imbalanced supply and demand of ESs at the urban agglomeration scale is limited. Therefore, in this study, using the Fujian Delta urban agglomeration of China as the research area, based on multi-source data, and analysis tools, such as ArcGIS, ENVI, and GeoDa, we constructed a research framework and indicator system for ESs supply and demand to determine the spatial change law, matching degree, and coupling coordination degree (CCD) of the ESs. On this basis, the key areas of imbalanced supply and demand of ESs were identified, and optimization strategies were proposed. The results showed that (1) there is obvious spatial heterogeneity between ESs supply and demand in the study area, and different degrees of spatial changes occurred with urbanization. Specifically, areas with large changes were concentrated in urban core areas and economic development zones. (2) The matching degree between ESs supply and demand is quite diverse and shows a trend of polarization. Under the influence of urbanization, some cities began facing ESs supply shortages. (3) Overall, the CCD between ESs supply and demand in the study area is in a state of mild incoordination, but with increasing urbanization, some cities have turned into a state of extreme incoordination. Our results indicate that the ESs supply and demand status in some cities at the urban agglomeration scale has become increasingly severe. Therefore, it is necessary to focus on certain "key areas" to formulate optimization strategies. For key areas with "low supply-high demand" and extreme incoordination, the population and land use intensity should be controlled to reduce the ESs demand level. Meanwhile, for key areas with "high supply-low demand" and extreme incoordination, the utilization efficiency of ecological resources should be improved to enhance the ESs supply capacity. The results of this study will help decision-makers optimize the relationship between ESs supply and demand in order to achieve the sustainable development of urban agglomeration.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148173DOI Listing
June 2021

Rac1, A Potential Target for Tumor Therapy.

Front Oncol 2021 17;11:674426. Epub 2021 May 17.

Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

RAS-related C3 botulinum toxin substrate 1 (Rac.1) is one of the important members of Rho GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell adhesion, morphology, and movement. Rac1 is highly expressed in different types of tumors, which is related to poor prognosis. Studies have shown that Rac1 not only participates in the tumor cell cycle, apoptosis, proliferation, invasion, migration and angiogenesis, but also participates in the regulation of tumor stem cell, thus promoting the occurrence of tumors. Rac1 also plays a key role in anti-tumor therapy and participates in immune escape mediated by the tumor microenvironment. In addition, the good prospects of Rac1 inhibitors in cancer prevention and treatment are exciting. Therefore, Rac1 is considered as a potential target for the prevention and treatment of cancer. The necessity and importance of Rac1 are obvious, but it still needs further study.
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http://dx.doi.org/10.3389/fonc.2021.674426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165220PMC
May 2021

Propofol maintains Th17/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p/NFATc2/NF‑κB axis.

Int J Mol Med 2021 07 26;48(1). Epub 2021 May 26.

Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.

Propofol is a commonly used intravenous anesthetic. The aim of the study was to examine the mechanism of propofol in traumatic brain injury (TBI) by regulating interleukin (IL)‑17 activity and maintaining the Th17/Treg balance. A rat model with moderate TBI was established using the weight‑drop method. Rats with TBI were regularly injected with propofol and their brain injuries were monitored. The peripheral blood of rats was collected to measure the Th17/Treg ratio. MicroRNA (miR)‑145‑3p expression was detected in the brain tissues of rats and antagomiR‑145‑3p was injected into the lateral ventricles of their brains to verify the effect of miR‑145‑3p on brain injury. The downstream target of miR‑145‑3p was predicted. The targeting relationship between miR‑145‑3p and nuclear factor of activated T cells c2 (NFATc2) was confirmed. NFATC2 expression and phosphorylation of NF‑κB pathway‑related proteins were measured. Propofol alleviated brain injury in rats with TBI and maintained the Th17/Treg balance. Propofol upregulated miR‑145‑3p expression in rat brains, while the inhibition of miR‑145‑3p reversed the effect of propofol on brain injury. A binding relationship was observed between miR‑145‑3p and NFATc2. Furthermore, propofol decreased the phosphorylation of p65 and IκBα, and inhibited activation of the NF‑κB pathway in the brains of rats with TBI. In conclusion, propofol maintained Th17/Treg balance and reduced inflammation in the rats with TBI via the miR‑145‑3p/NFATc2/NF‑κB axis.
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http://dx.doi.org/10.3892/ijmm.2021.4968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148094PMC
July 2021

Use of Video Telehealth Tablets to Increase Access for Veterans Experiencing Homelessness.

J Gen Intern Med 2021 May 23. Epub 2021 May 23.

VA Center for Innovation to Implementation (Ci2i), VA Palo Alto Health Care System, Menlo Park, CA, USA.

Background: Veterans experiencing homelessness face substantial barriers to accessing health and social services. In 2016, the Veterans Affairs (VA) healthcare system launched a unique program to distribute video-enabled tablets to Veterans with access barriers.

Objective: Evaluate the use of VA-issued video telehealth tablets among Veterans experiencing homelessness in the VA system.

Design: Guided by the RE-AIM framework, we first evaluated the adoption of tablets among Veterans experiencing homelessness and housed Veterans. We then analyzed health record and tablet utilization data to compare characteristics of both subpopulations, and used multivariable logistic regression to identify factors associated with tablet use among Veterans experiencing homelessness.

Patients: In total, 12,148 VA patients receiving tablets between October 2017 and March 2019, focusing on the 1470 VA Veterans experiencing homelessness receiving tablets (12.1%).

Main Measures: Tablet use within 6 months of receipt for mental health, primary or specialty care.

Key Results: Nearly half (45.9%) of Veterans experiencing homelessness who received a tablet had a video visit within 6 months of receipt, most frequently for telemental health. Tablet use was more common among Veterans experiencing homelessness who were younger (AOR = 2.77; P <.001); middle-aged (AOR = 2.28; P <.001); in rural settings (AOR = 1.46; P =.005); and those with post-traumatic stress disorder (AOR = 1.64; P <.001), and less common among those who were Black (AOR = 0.43; P <.001) and those with a substance use disorder (AOR = 0.59; P <.001) or persistent housing instability (AOR = 0.75; P = .023).

Conclusions: Telehealth care and connection for vulnerable populations are particularly salient during the COVID-19 pandemic but also beyond. VA's distribution of video telehealth tablets offers healthcare access to Veterans experiencing homelessness; however, barriers remain for subpopulations. Tailored training and support for these patients may be needed to optimize telehealth tablet use and effectiveness.
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http://dx.doi.org/10.1007/s11606-021-06900-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141357PMC
May 2021

Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma.

Mol Cancer 2021 03 29;20(1):57. Epub 2021 Mar 29.

Department of Gynecologic Oncology, Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.

Endometrial cancer (EC) is a major cause of death among gynecologic malignancies. To improve early detection of EC in patients, we carried out a large plasma-derived exosomal microRNA (miRNA) studies for diagnostic biomarker discovery in EC. Small RNA sequencing was performed to identify candidate exosomal miRNAs as diagnostic biomarkers in 56 plasma samples from healthy subjects and EC patients. These miRNA candidates were further validated in 202 independent plasma samples by droplet digital PCR (ddPCR), 32 pairs of endometrial tumors and adjacent normal tissues by quantitative real-time PCR (qRT-PCR), and matched plasma samples of 12 patients before and after surgery by ddPCR. miR-15a-5p, miR-106b-5p, and miR107 were significantly upregulated in exomes isolated from plasma samples of EC patients compared with healthy subjects. Particularly, miR-15a-5p alone yielded an AUC value of 0.813 to distinguish EC patients with stage I from healthy subjects. The integration of miR-15a-5p and serum tumor markers (CEA and CA125) achieved a higher AUC value of 0.899. There was also a close connection between miR-15a-5p and clinical manifestations in EC patients. Its exosomal expression was not only associated with the depth of muscular infiltration and aggressiveness of EC, but also correlated with levels of reproductive hormones such as TTE and DHEAS. Collectively, plasma-derived exosomal miR-15a-5p is a promising and effective diagnostic biomarker for the early detection of endometrial cancer.
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http://dx.doi.org/10.1186/s12943-021-01352-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006369PMC
March 2021

Biological Function of HYOU1 in Tumors and Other Diseases.

Onco Targets Ther 2021 5;14:1727-1735. Epub 2021 Mar 5.

Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People's Republic of China.

Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.
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http://dx.doi.org/10.2147/OTT.S297332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943547PMC
March 2021

Intelligent spectral algorithm for pigments visualization, classification and identification based on Raman spectra.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 29;250:119390. Epub 2020 Dec 29.

College of Optical and Electronic Technology, China Jiliang University, 310018 Hangzhou, China.

Raman spectroscopy is a molecular vibrational spectroscopic technique has developed rapidly in recent years, especially in rapid field detection. In this paper, we discuss the Raman spectral pretreatment method and classification algorithm by using nearly 300 pigments spectral data as an example. Here, more than 5 kinds of classification algorithms such as SVM, KNN, ANN and et al are used to sovle the problem of pigments visualization, classification and identification via Raman spectral, and the results show that most of the algorithms fit well, with an accuracy of 90%. Moreover, SNR (Signal to noise ratio) is introduced to evaluate the stability of our algorithm. When the SNR is low, the accuracy of the algorithm decreases sharply. When the SNR was 1, the accuracy rate reached the highest value of 39.46%. In order to slove this problem, the flattopwin, hanning, blackman algorithm was introduced to denoise the signal with low SNR, even when SNR = 1, the signal is 80% accurate. It is proved that in the extreme case of this application, the algorithm still maintains good accuracy, and our research pave the way to use interlligent algorithms to solve the problems in the fields of Raman spectral detection.
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http://dx.doi.org/10.1016/j.saa.2020.119390DOI Listing
April 2021

A novel approach for determining the accurate debromination time in the ball-milling process of nonmetallic particles from waste printed circuit boards by computation.

J Hazard Mater 2021 05 19;410:124611. Epub 2020 Nov 19.

School of Environmental Science and Engineering, Sun Yat-Sen University, 135 Xingang Xi Road, Guangzhou 510275, People's Republic of China. Electronic address:

Ball-milling technology is adopted for the debromination of nonmetallic particles of waste printed circuit boards. During the ball-milling process, too short ball-milling time causes insufficient debromination. Excessive ball-milling leads to the waste of resources and the destruction of the main structure of nonmetallic particles resin, unfavorable for the secondary utilization. However, how to determine debromination time of nonmetallic particles in ball-milling process has not been detailed studied. In this study, the ball-milling energy was coupled with the degradation energy of pentabromodiphenyl ether molecule to compute the time for each chemical bond to break. The ball-milling model was used to accurately compute effective mechanical ball-milling energy (1.234 × 10 J) generated by a single collision. The average bond energies of C‒O bond, C‒Br bond and C‒H bond (261.24, 302.05 and 489.50 kJ/mol) were analyzed by density functional theory. Under the conditions of 220 r/min and 1.2 g nonmetallic particles and NZVI (4:1). The C‒O bond, C‒Br bond, and C‒H bond fractured completely in turn at 2.25 h, 7.23 h (optimal debromination time), and 11.72 h. Based on the analysis of debromination pathways, it inferred that HO, HBr, CHBr, CH, FeBr, and graphite were generated. This paper develops a novel idea of the schedule of debromination time of nonmetallic particles, contributing to the directional removal of organic pollutants by ball-milling.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124611DOI Listing
May 2021

Direct competitive ELISA enhanced by dynamic light scattering for the ultrasensitive detection of aflatoxin B in corn samples.

Food Chem 2021 Apr 8;342:128327. Epub 2020 Oct 8.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China; School of Food Science and Technology, Nanchang University, Nanchang 330047, PR China; Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, PR China. Electronic address:

Compared with absorbance, scattering-based dynamic light scattering (DLS) signal has higher sensitivity because its light-scattering intensity is very sensitive to changes in size, thereby enhancing the sensitivity. Herein, we first developed a DLS-enhanced direct competitive enzyme-linked immunosorbent assay (DLS-dcELISA) for ultrasensitive detection of aflatoxin B (AFB) in corn. By using hydroxyl radical-induced gold nanoparticle (AuNP) aggregation to amplify AuNP scattering signals, the developed DLS-dcELISA exhibited ultrahigh sensitivity for AFB. The detection limit was 0.12 pg mL, which was 153- and 385-fold lower than those obtained using plasmonic and colorimetric dcELISA. In addition, the DLS-dcELISA exhibited excellent selectivity, high accuracy, and strong practicality. Overall, this work presented a simple and universal strategy for improving the sensitivity of traditional ELISA platform only by using the sensitive DLS signals. This technique can replace absorbance-based plasmonic or colored signals as immunoassay signal output for enhanced competitive detection of mycotoxins.
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http://dx.doi.org/10.1016/j.foodchem.2020.128327DOI Listing
April 2021

HbA1c variability as an independent predictor of diabetes retinopathy in patients with type 2 diabetes.

J Endocrinol Invest 2021 Jun 8;44(6):1229-1236. Epub 2020 Sep 8.

Endocrinology Department, Hainan General Hospital, No.19, Xiuhua Road, Xiuying District, Haikou, 570311, Hainan, China.

Aims: To evaluate the association of both mean HbA1c and HbA1c variability with DR development in patients with type 2 diabetes.

Methods: Patients with type 2 diabetes who received dilated funduscopic examination annually and who underwent at least 2-year follow-up were included in this longitudinal study. Subjects were excluded if they took less than five HbA1c measurements during the follow-up period. HbA1C variability was expressed as A1c-SD, and the mean of HbA1c (A1c-Mean) was calculated. In addition, medical history and clinical data of all subjects were collected and analyzed. According to A1c-Mean above or below the value 7% and A1c-SD above or below the population mean value 0.76%, subjects were divided into four quartiles: Q1(A1c-Mean < 7%, A1c-SD < 0.76%); Q2(A1c-Mean < 7%, A1c-SD ≥ 0.76%); Q3(A1c-Mean ≥ 7%, A1c-SD < 0.76%); Q4(A1c-Mean ≥ 7%, A1c-SD ≥ 0.76%).

Results: 3152 participants were included in the study analysis with a median follow-up period of 3.95 years (2-5 years), 17.6% (n = 556) were found to have DR, and these patients also had higher HbA1c levels (P < 0.001). Linear mixed-effect models were performed after adjusting for the characteristics of participants and the results showed that HbA1c variability is an independent risk factor for DR. Cox regression revealed that patients in Q4 group had the highest DR prevalence (HR = 1.624, P < 0.001) while Q1 group had the lowest. In addition, patients in Q2 group (HR = 1.429, P = 0.006) had a higher risk of DR than those in Q3 group (HR = 1.334, P < 0.001).

Conclusions: HbA1c variability is an independent predictor of DR in patients with type 2 diabetes in Asia. It may play a greater role in DR development than mean HbA1c does when the mean value of HbA1c variability index is above 0.75%, indicating that aggressive A1c lowering strategies may, in fact, contribute excessively to risk of DR in patients with type 2 diabetes; steady decline of A1c should be taken into consideration.
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http://dx.doi.org/10.1007/s40618-020-01410-6DOI Listing
June 2021

Single-Sample Node Entropy for Molecular Transition in Pre-deterioration Stage of Cancer.

Front Bioeng Biotechnol 2020 14;8:809. Epub 2020 Jul 14.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.

A complex disease, especially cancer, always has pre-deterioration stage during its progression, which is difficult to identify but crucial to drug research and clinical intervention. However, using a few samples to find mechanisms that propel cancer crossing the pre-deterioration stage is still a complex problem. In this study, we successfully developed a novel single-sample model based on node entropy with established protein interaction network. Using this model, critical stages were successfully detected in simulation data and four TCGA datasets, indicating its sensitivity and robustness. Besides, compared with the results of the differential analysis, our results showed that most of dynamic network biomarkers identified by node entropy, such as or , located in upstream in many important cancer-related signaling pathways regulated intergenic signaling within pathways. We also identified some novel prognostic biomarkers such as , , and using node entropy rather than expression level. More importantly, we found the switch of non-specific pathways related to DNA damage repairing was the main driven force for cancer progression. In conclusion, we have successfully developed a dynamic node entropy model based on single case data to find out tipping point and possible mechanism for cancer progression. These findings may provide new target genes in therapeutic intervention tactics.
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http://dx.doi.org/10.3389/fbioe.2020.00809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381145PMC
July 2020

Growth and Cellular Responses of Toxigenic Microcystis to Chloramphenicol-Stress at Various Environmentally-Relevant Nitrogen Levels.

Bull Environ Contam Toxicol 2020 Aug 16;105(2):337-344. Epub 2020 Jul 16.

College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.

This study explored nitrogen (N)-dependent interaction between Microcystis and chloramphenicol (CAP) along 20 day-test. Results showed that 5 mg/L N largely alleviated inhibitory effects of CAP on Microcystis growth, while 50 and 0.5 mg/L N exacerbated growth-inhibition by CAP especially in early (before day 8) and mid-late stage, respectively. At each N level, CAP-induced antioxidant defense and cell damage extents were negatively correlated to growth state in each stage, and CAP-biodegradation coincided with Microcystis growth and glutathione synthesis dynamics, implying that antioxidant defense, cell damage and CAP-removal closely linked to N-dependent Microcystis growth under CAP-stress. Microcystin (MC)-production and -release under CAP-stress were also N-dependent. Although Microcystis growth was greatly-inhibited by prolonged CAP-stress at 0.5 mg/L N, delayed CAP-loss and high MC-release at 0.5 mg/L N should be emphasized during Microcystis-dominated cyanobacterial blooms (MCBs) and CAP co-occurrence. This study had great implication in risk assessment for MCBs-CAP co-occurrence in different waters.
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http://dx.doi.org/10.1007/s00128-020-02935-5DOI Listing
August 2020

Three-Dimensional Printed Model Fabrication and Effectiveness Evaluation in Fetuses With Congenital Heart Disease or With a Normal Heart.

J Ultrasound Med 2021 Jan 20;40(1):15-28. Epub 2020 Jun 20.

Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, China.

Objectives: The purpose of this study was to investigate the technical feasibility and accuracy of applying 3-dimensional (3D) printing of normal and abnormal fetal hearts based on spatiotemporal image correlation (STIC) volume-rendered data.

Methods: Spatiotemporal image correlation volume images of 15 healthy fetuses and 15 fetuses with cardiac abnormalities were collected, and Mimics software (Materialise NV, Leuven, Belgium) was used to postprocess the volume data to obtain a 3D digital model of fetal heart and large blood vessel morphologic characteristics and to output the file to a 3D printer for printing the 3D model of the fetal heart and large blood vessels. The effect accuracy of the 3D printed model was qualitatively evaluated by showing the 3D anatomic structure of the model combined with echocardiographic or autopsy results, and the dimensional accuracy of the 3D printed model was quantitatively evaluated by comparing the measured data of the model and echocardiography.

Results: In all 30 fetuses, STIC volume data of the fetal heart were successfully reprocessed and printed out, which could visually display the morphologic characteristics of the fetal heart chamber and passage of the great vessels under normal and abnormal pathologic conditions. No significant differences in all of the heart size parameters were found between the 3D digital model, 3D printed model, and routine echocardiographic images (all P > .05). Moreover, the size parameters were concordant well between the methods, and all of the data points fell within the limits of agreement.

Conclusions: It is feasible to 3D print the fetal heart using STIC volumetric images as the data source, and the 3D printed model can fully and accurately display abnormal anatomic structures of the heart.
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http://dx.doi.org/10.1002/jum.15366DOI Listing
January 2021

Patient Perceptions of Video Visits Using Veterans Affairs Telehealth Tablets: Survey Study.

J Med Internet Res 2020 04 15;22(4):e15682. Epub 2020 Apr 15.

Center for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA, United States.

Background: Video-based health care can help address access gaps for patients and is rapidly being offered by health care organizations. However, patients who lack access to technology may be left behind in these initiatives. In 2016, the US Department of Veterans Affairs (VA) began distributing video-enabled tablets to provide video visits to veterans with health care access barriers.

Objective: This study aimed to evaluate veterans' experiences with VA-issued tablets and identify patient characteristics associated with preferences for video visits vs in-person care.

Methods: A baseline survey was sent to the tablet recipients, and a follow-up survey was sent to the respondents 3 to 6 months later. Multivariate logistic regression was used to identify patient characteristics associated with preferences for care, and we examined qualitative themes around care preferences using standard content analysis methods for coding the data collected in the open-ended questions.

Results: Patient-reported access barriers centered around transportation and health-related challenges, outside commitments, and feeling uncomfortable or uneasy at the VA. Satisfaction with the tablet program was high, and in the follow-up survey, approximately two-thirds of tablet recipients preferred care via a tablet (194/604, 32.1%) or expressed that video-based and in-person care were "about the same" (216/604, 35.7%), whereas one-third (192/604, 31.7%) indicated a preference for in-person care. Patients were significantly more likely to report a preference for video visits (vs a preference for in-person visits or rating them "about the same") if they felt uncomfortable in a VA setting, reported a collaborative communication style with their doctor, had a substance use disorder diagnosis, or lived in a place with better broadband coverage. Patients were less likely to report a preference for video visits if they had more chronic conditions. Qualitative analyses identified four themes related to preferences for video-based care: perceived improvements in access to care, perceived differential quality of care, feasibility of obtaining necessary care, and technology-related challenges.

Conclusions: Many recipients of VA-issued tablets report that video care is equivalent to or preferred to in-person care. Results may inform efforts to identify good candidates for virtual care and interventions to support individuals who experience technical challenges.
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http://dx.doi.org/10.2196/15682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191342PMC
April 2020

Pregnancy Outcomes in Patients With Heart Disease in China.

Am J Cardiol 2020 06 16;125(11):1718-1724. Epub 2020 Mar 16.

Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

To analyze pregnancy outcomes of patients with heart disease in a single center and to explore the risk factors of adverse outcomes. One thousand thirty-three pregnant women with heart disease were retrospectively included from 2010 to 2017. We collected data of maternal, obstetric, and fetal outcomes. Among 1,086 pregnancies, 295 (27.1%) with congenital heart disease, 244 (22.5%) with rheumatic heart disease, 387 (35.6%) with arrhythmia, and 55 (5.1%) with cardiomyopathy. There were 8 (0.7%) maternal deaths. Risk factors of mortality were New York Heart Association (NYHA) classification IV (p <0.001), cardiac surgery during pregnancy (p <0.001), and general anesthesia (p <0.001). Maternal cardiac complications occurred in 6.7% of women, with most in the cardiomyopathy (26.0%) and rheumatic heart disease (32.9%) groups. Multivariate logistic regression modeling was used to analyze the potential risk factors. NYHA classification III and IV independently predicted worse maternal outcomes. Peripartum intensive care unit admission rate was 10.2%. Admission to intensive care unit was associated with NYHA classification II/III/IV, modified World Health Organization (mWHO) classification II-III/III/IV, and cardiac surgery during pregnancy. In conclusion, pregnancy with heart disease is at higher risk of complications for both women and neonates. In our findings, maternal morbidity is associated with NYHA classification and mWHO classification.
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http://dx.doi.org/10.1016/j.amjcard.2020.02.043DOI Listing
June 2020

Growth, physiological responses and microcystin-production/-release dynamics of Microcystis aeruginosa exposed to various luteolin doses.

Ecotoxicol Environ Saf 2020 Jun 3;196:110540. Epub 2020 Apr 3.

College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China; Beijing Key Laboratory of Biodiversity and Organic Farming, China Agricultural University, Beijing, 100193, China.

By testing time-dependent IC of luteolin against Microcystis growth, this study revealed 6.5 mg/L as nearly IC value during prolonged stress until day 14, and explored chlorophyll-a (CLA) and phycobiliproteins (PBPs) contents, antioxidant responses and microcystin (MC)-production/-release dynamics at rising luteolin doses (0.5~2-fold IC). Growth inhibition ratio (GIR) generally rose at rising luteolin dose, while at each dose GIR firstly increased and then leveled off or dropped. In early stage, CLA, allophycocyanin (APC), phycoerythrin (PE) and glutathione (GSH) contents, and superoxide dismutase (SOD) and catalase (CAT) activities, were increasingly stimulated at rising luteolin dose to enhance energy yield and antioxidant defense, but Microcystis was damaged more severely at rising dose, due to stress-repair imbalance. Such more severe damage in early stage, coupled with stronger PBPs-inhibition in mid-late stage, at rising dose could jointly account for rising GIR at rising dose. The CAT/GSH-stimulation persisting until late stage could alleviate cell damage in late stage, which explained for why GIR no longer increased in late stage at each luteolin dose. Besides, more MCs were produced and retained in cell to exert protective roles against luteolin-stress in early stage, but intracellular MCs decreased following inhibited MC-production by prolonged stress to decrease cell protectant. Extracellular MCs detection showed that less MCs amount existed in water phase than control along luteolin-stress, implying luteolin as eco-friendly algaecide with promising potential to remove MPM blooms and MC-risks. This is the first study to reveal the effect of various luteolin doses on MC-production/release and PBP-synthesis dynamics of Microcystis during prolonged stress. The findings shed novel views in anti-algal mechanisms of luteolin, and provided direct evidence for luteolin applied as safe agent to remediate Microcystis-dominant blooms.
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http://dx.doi.org/10.1016/j.ecoenv.2020.110540DOI Listing
June 2020

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway.

Environ Int 2020 05 5;138:105624. Epub 2020 Mar 5.

Department of Environmental Sciences, University of California, Riverside, CA 92521, United States.

Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common antibiotics; cefotaxime, enrofloxacin, tetracycline, sulfamonomethoxine, and their mixtures, and explored the immunomodulatory effects associated with the nuclear factor-κB (NF-κB) signaling pathway. A KEGG pathway analysis was conducted using the sixty-six differentially expressed genes found in all treatments, and showed that exposure to 100 μg/L of antibiotics could affect regulation of the NF-κB signaling pathway, suggesting that activation of NF-κB is a common response in all four classes of antibiotics. In addition, the four antibiotics induced nf-κb and NF-κB-associated cytokines expression, as verified by qPCR, however, these induction responses by four antibiotics were minor when compared to the same concentration of LPS treatment (100 μg/L). Antagonists of NF-κB blocked many of the immune effects of the antibiotics, providing evidence that NF-κB pathways mediate the actions of all four antibiotics. Moreover, exposure to environmentally relevant, low levels (0.01-100 μg/L) of antibiotics induced a NF-κB-mediated immune response, including endogenous generation of ROS, activity of antioxidant enzymes, as well as expression of cytokine and apoptosis. Moreover, exposure to mixtures of antibiotics presented greater effects on most tested immunological parameters than exposure to a single antibiotic, suggesting additive effects from multiple antibiotics in the environment. This study demonstrates that exposure of fish primary macrophages to low doses of antibiotics activates the NF-kB pathway.
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http://dx.doi.org/10.1016/j.envint.2020.105624DOI Listing
May 2020

Virtual Savings: Patient-Reported Time and Money Savings from a VA National Telehealth Tablet Initiative.

Telemed J E Health 2020 09 26;26(9):1178-1183. Epub 2019 Dec 26.

VA Center for Innovation to Implementation (Ci2i), Palo Alto Veterans Health Administration, Menlo Park, California, USA.

Virtual care holds promise for offering services to Veterans Affairs (VA) patients who have barriers to accessing care. In 2016, the VA began issuing video-enabled tablets to Veterans with geographic, clinical, and/or social barriers to in-person care. To complement a national evaluation of system-level implementation and effectiveness of these tablets, we sought to understand whether the VA-issued tablets generated money and/or time savings for patients. We distributed a survey to 2,120 Veterans who received tablets and administered a follow-up survey 3-6 months later. The final analysis included 594 and 399 patients who responded to questions about money and time savings, respectively. We used poststratification survey weighting methods to address potential selection and nonresponse bias. In multinomial logistic regressions and logistic regressions, we examined patient characteristics associated with reported money and time savings. A majority of survey respondents reported that the tablets saved them money (89%) and time (71%). Respondents were more likely to report monetary savings if they lived at a greater distance from the VA, if they experienced travel barriers, and if they did not have a mental health condition. Respondents were more likely to report time savings if they were <45 or ≥65 years of age, employed, and reported more overall technology experience. Findings may inform policy decisions regarding patient targeting and training as VA aims to expand its use of video telehealth technology.
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http://dx.doi.org/10.1089/tmj.2019.0179DOI Listing
September 2020

Rapid, simplified microscale quantitative analysis of lignin H/G/S composition with GC-MS in glass ampules and glass capillaries.

MethodsX 2019 7;6:2592-2600. Epub 2019 Nov 7.

Research Institution of Forestry, Chinese Academy of Forestry, Beijing, China.

The characterization of monolignols H-, G- and S- units composition Vanholme et al. (2010) of lignin is important in agriculture, forestry, herb medicine, livestock, and health care research Vanholme et al. (2008) and Sticklen (2008). The conventional methods often require a great deal of samples and reagents and are time-consuming. Here, we present a newly developed method with fewer operations. The optimized method is suitable for detecting and characterizing lignin composition of cell wall in different plant species and has the advantages of: •Avoiding the influence of plasticizer by plasticware and enhancing the accuracy of monolignols analysis.•Lowering the required samples from grams to milligrams, and organic reagents from milliliters to microliters.•Reducing the time required from a few days to 6 h.
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http://dx.doi.org/10.1016/j.mex.2019.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861596PMC
November 2019

Methamphetamine-Induced Cognitive Deficits and Psychiatric Symptoms Are Associated with Serum Markers of Liver Damage.

Neurotox Res 2020 Jan 5;37(1):67-76. Epub 2019 Nov 5.

School of Mental Health, Bengbu Medical College, Bengbu, Anhui, China.

Cognitive deficits and psychiatric disorders have been regarded as the most common clinical symptoms of methamphetamine (MA) users. Accumulating evidence has shown that liver disease may be involved in cognitive deficits and psychiatric disorders. This study examines whether cognitive deficits and psychiatric symptoms are associated with serum levels of liver biomarkers in MA users. Cognition was assessed by the Repeatable Battery for the Assessment of neuropsychological Status (RBANS). Psychiatric symptoms were assessed by the Symptom Checklist-90 (SCL-90). Liver function was assessed by serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, Apolipoprotein B (ApoB), triglyceride, total cholesterol, and glucose concentrations in 106 MA addicts and 76 controls. Compared to control subjects, MA users had greater severity of psychotic symptoms on the dimension of somatization, depression, anxiety, psychoticism, addiction, and global severity index in SCL-90, and lower scores of cognition, including the total RBANS score and all five subscales. The globulin levels were increased, while the albumin, albumin/globulin, and ApoB levels were decreased. ApoB levels were positively correlated with immediate memory, attention, and total RBANS score. Furthermore, stepwise multivariate regression analysis indicated that ApoB levels were associated with immediate memory, attention, and total RBANS score. The findings of this study suggest that MA addicts might experience cognitive deficits, psychiatric disorders, and liver damage. Serum ApoB levels may be involved in cognitive deficits; thus, improving liver function may help to treat cognitive deficits and psychiatric disorders in MA addicts.
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http://dx.doi.org/10.1007/s12640-019-00115-wDOI Listing
January 2020

Effect of acupoint therapies on chemotherapy-induced nausea and vomiting: A systematic review protocol.

Medicine (Baltimore) 2019 Sep;98(37):e17109

Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.

Background: Patients suffering from chemotherapy-induced nausea and vomiting (CINV) might have negative adherence of treatment. Acupoint therapies, including acupuncture, acupressure, acupoints injection, massage, and moxibustion, are safe medical procedures with minimal side effects for CINV, but studies about overall safety and effectiveness of acupoint therapies have not been scientifically and methodically evaluated in recent years. Evaluating the overall safety and effectiveness of acupoint therapies in patients with CINV is the purpose of this review.

Methods And Analysis: Relevant randomized controlled trials (RCTSs) are being searched in the following electronic databases: PubMed, Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP database), Wanfang Data Knowledge Service Platform, and Chinese Biomedical Literature Database (CBM). We will also attempt to obtain the unpublished academic data by contacting the colleague, professor, or Institute of Traditional Chinese Medicine. The RCTs of the acupoint therapies for CINV patients will be searched in the databases from inception to July 2019. The primary outcomes are defined as severity, duration and frequency of nausea or vomiting, or both. The secondary outcomes are defined as any adverse events and quality of life. Performing the meta-analysis by using RevMan version 5 software. Mean difference (MD) or standardized mean difference (SMD) will express the continuous variables, while relative risk (RR) will express the categorical variables.

Results: The results of this review will provide a high-quality synthesis to evaluate the effectiveness and safety of acupoint therapies for CINV.

Conclusion: This review will provide evidence to estimate whether acupoint therapies are effective interventions for CINV.

Dissemination: Evidence whether acupoint therapies are effective interventions for CINV will be provided by this systematic review. This knowledge will recommend better acupoint therapies and selections of acupoints which might be helpful in treating CINV. The findings of this systematic review will be disseminated via various forms of presentation and publication of the data in a journal or electronic databases.

Prospero Registration Number: CRD42019125538.
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http://dx.doi.org/10.1097/MD.0000000000017109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750289PMC
September 2019

Years of Potential Life Lost from Cardiovascular Disease Among Hispanics.

Ethn Dis 2019 18;29(3):477-484. Epub 2019 Jul 18.

Department of Cardiovascular Medicine, Stanford University, Stanford, CA.

Objective: To quantify the impact of cardiovascular disease and its subtypes on the premature mortality of Hispanics in the United States.

Methods: We used national death records to identify deaths for the three largest Hispanic subgroups (Mexicans, Puerto Ricans, and Cubans) in the United States from 2003 to 2012 (N = 832,550). We identified all deaths from cardiovascular disease and by subtype (ie, ischemic, cerebrovascular, hypertensive and heart failure) using the underlying cause of death via ICD-10 codes. Years of potential life lost (YPLL) was calculated by age categories standardizing with the 2000 US Census population. Population estimates were calculated using linear interpolation from 2000 and 2010 US Census data.

Results: After standardization, Puerto Ricans experienced the highest YPLL for all types of cardiovascular disease compared with Mexicans and Cubans (1,139 years per 100,000 compared with 868 and 841, respectively), a disparity that remained consistent over the course of a decade. Among different subcategories of cardiovascular disease, Puerto Ricans had the highest YPLL for ischemic and hypertensive heart disease, while Mexicans had the highest YPLL from cerebrovascular disease.

Conclusions: In conclusion, disaggregation of Hispanic subgroups revealed marked heterogeneity in premature cardiovascular mortality. These findings suggest that measures to improve the cardiovascular health of Hispanics should incorporate subgroup status as a key part of public health strategy.
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http://dx.doi.org/10.18865/ed.29.3.477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645724PMC
June 2020

Clinical pattern of antibiotic overuse and misuse in primary healthcare hospitals in the southwest of China.

PLoS One 2019 26;14(6):e0214779. Epub 2019 Jun 26.

School of Medicine and Health Management, Guizhou Medical University, Guizhou, China.

Purpose: Overuse and misuse of antibiotics are the primary risk factors for antibiotics resistance. Inadequate professional competence of primary care physicians might exacerbate these problems in China. This retrospective study aims to document the clinical pattern of antibiotics use and its overuse and misuse rates in rural primary care institutions and to evaluate the association between antibiotics use and characteristics of physicians and their patients.

Methods: Medical records from 16 primary care hospitals in rural areas of Guizhou province, China were obtained from the Health Information System in 2018. Classification of unnecessary use, incorrect spectrum of antibiotic, escalated use of extended spectrum and combined antibiotics use was based on the Guiding Principle of Clinical Use of Antibiotics (2015, China) and guidelines from the US Centers for Disease Control and Prevention. Generalized Estimating Equations were employed to determine predictive factors for inappropriate antibiotics use.

Results: A total of 74,648 antibiotics prescriptions were retrieved. Uncomplicated respiratory infection was the most common disease accounting for 58.6% of all prescriptions. The main antibiotic group used was penicillins (51.5%) followed by cephalosporins and macrolides (14% each). Of 57,009 patient visits, only 8.7% of the antibiotic prescriptions were appropriate. Combined use, escalated use of extended spectrum antibiotics, incorrect spectrum and unnecessary antibiotics use was found in 7.8%, 1.9%, 4.3% and 77.3% of patient visits, respectively, of which 28.7% were given intravenously. Antibiotics misuse was significantly more likely among newly employed physicians with lower levels of professional education. Adult patients and those who had public insurance had a higher risk of being prescribed unnecessary antibiotics.

Conclusion: Overuse of antibiotics for uncomplicated respiratory infection and use of cephalosporins, macrolides and injection antibiotics in primary care are the major problems of clinical practice in rural areas of Guizhou.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594576PMC
January 2020

Disaggregating Hispanic American Cancer Mortality Burden by Detailed Ethnicity.

Cancer Epidemiol Biomarkers Prev 2019 08 30;28(8):1353-1363. Epub 2019 May 30.

School of Public Health, San Diego State University, San Diego, California.

Background: Hispanics are the largest minority population in the United States (18%). They represent a heterogeneous and growing population. Cancer is the leading cause of death among Hispanics, yet few studies have described cancer mortality burden by specific Hispanic group nationwide.

Methods: Cancer-related deaths from U.S. death certificates for the years 2003-2012 were analyzed for decedents identifying as Mexican, Puerto Rican, Cuban, and Central or South American. We calculated descriptive statistics, including potential years of lives lost (PYLL), age-adjusted rates, standardized mortality ratios, and fitted JoinPoint regression models, to evaluate annual trends by Hispanic group, using non-Hispanic Whites (NHW) as the reference population.

Results: We identified 287,218 cancer-related deaths among Hispanics and 4,570,559 among NHWs. Mortality trends were heterogeneous across Hispanic groups. Female NHWs and male Puerto Ricans had the greatest rates of adjusted PYLL per 1,000 (NHWs, 19.6; Puerto Ricans, 16.5). Liver cancer was ranked among the top 5 cancer-related deaths for every Hispanic group, but not for NHWs. Stomach cancer mortality was twice as high for most Hispanic groups when compared with NHWs and especially high for Mexicans [male standardized mortality ratio (SMR), 2.07; 95% confidence interval (CI), 2.01-2.13; female SMR, 2.62; 95% CI, 2.53-2.71].

Conclusions: We observed marked heterogeneity in cancer mortality across Hispanic groups. Several cancers affect Hispanics disproportionately compared with NHWs. Screening programs in Hispanics should be considered for stomach and liver cancer.

Impact: Disaggregated analysis of Hispanics is needed to fully understand cancer burden among the diverse Hispanic population and is critical for cancer prevention and control efforts.
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771432PMC
August 2019

The association of Trisomy 13 and 18 and hospital discharge outcomes among neonates in California: A retrospective cohort study.

Pediatr Neonatol 2019 12 2;60(6):617-622. Epub 2019 Mar 2.

Fetal and Neonatal Medicine Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, United States; Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, 90089, United States; USC Gehr Family Center for Health Systems Science, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, United States. Electronic address:

Background: Despite Trisomy 13 and 18 being among the most fatal congenital anomalies, limited information exists about resource utilization and factors associated with length of stay (LOS) and total hospital charges (THC) for these anomalies.

Methods: We studied data sets of the patient discharge data set from the California Office of Statewide Health Planning and Development from 2006 to 2010, to determine differences in resource utilization for survivors and non-survivors and identify the predictors of LOS and total hospital charges. Descriptive statistics were assessed for demographic and clinical characteristics. General linear regression models were used to identify predictors of LOS and THC.

Results: Seventy-six Trisomy 13 and 115 Trisomy 18 patients were identified, for whom inpatient mortality was 27.6% and 20.9%, respectively. In patients with Trisomy 13, after adjusting for gender, ethnicity, advanced directive (DNR), insurance and co-morbidities on multivariate analysis, the provision of more than 96 h of mechanical ventilation was associated with significantly increased LOS (standard error, SE) by 18.0 ± 5.3 days and THC (SE) by $399,000 ± $85,000. In terms of insurance type, patients with private coverage had 10.8 ± 4.9 days more than patients with Medicaid. In patients with Trisomy 18, on multivariate analysis, after adjusting for gender, ethnicity, DNR, insurance and co-morbidities, more than 96 h of mechanical ventilation was associated with increased LOS (SE) by 36.8 ± 6.8 days and THC (SE) by $365,000 ± $59,000.

Conclusion: Understanding predictors that are associated with longer LOS and higher THC may be associated in hospital resource allocation for this vulnerable population of infants.
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http://dx.doi.org/10.1016/j.pedneo.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062359PMC
December 2019

Years of Potential Life Lost Because of Cardiovascular Disease in Asian-American Subgroups, 2003-2012.

J Am Heart Assoc 2019 04;8(7):e010744

2 Division of Primary Care and Population Health Stanford University School of Medicine Stanford CA.

Background Asian-American subgroups (Asian-Indian, Chinese, Filipino, Korean, Japanese, and Vietnamese) display varied cardiovascular disease mortality patterns, especially at younger ages. This study aims to examine the years of potential life lost because of ischemic heart disease and cerebrovascular disease among the 6 largest Asian-American subgroups compared with non-Hispanic whites. Methods and Results We used National Center for Health Statistics Multiple Causes of Death mortality files from 2003 to 2012 to calculate race-specific life expectancy, mean years of potential life lost, and years of potential life lost per 100 000 population for each Asian subgroup and non-Hispanic whites. Asian-American subgroups display heterogeneity in cardiovascular disease burden. Asian-Indians had a high burden of ischemic heart disease; Asian-Indian men lost 724 years per 100 000 population in 2012 and a mean of 17 years to ischemic heart disease. Respectively, Vietnamese and Filipino men and women lost a mean of 17 and 16 years of life to cerebrovascular disease; Filipino men lost 352 years per 100 000 population in 2012. All Asian subgroups for both sexes had higher years of life lost to cerebrovascular disease compared with non-Hispanic whites. Conclusions Cardiovascular disease burden varies among Asian subgroups, and contributes to greater premature mortality in certain subgroups. Asian-Indian and Filipino populations have the highest years of life lost because of ischemic heart disease and Filipino and Vietnamese have the highest years of life lost because of cerebrovascular disease. Analysis of risk factors and development of subgroup-specific interventions are required to address these health disparities.
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http://dx.doi.org/10.1161/JAHA.118.010744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509739PMC
April 2019

Sickle cell trait and renal disease among African American U.S. Army soldiers.

Br J Haematol 2019 05 11;185(3):532-540. Epub 2019 Mar 11.

Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.

Sickle cell trait and certain renal disorders are disproportionately prevalent among African American individuals, so a clear understanding of their association is important. We conducted a longitudinal study using the Stanford Military Data Repository to examine sickle cell trait in relation to the incidence of acute kidney injury (AKI) and chronic kidney disease (CKD). Our study population consisted of African American U.S. Army soldiers on active duty between January 2011 and December 2014. The cumulative incidence was 0·51% for AKI (236 cases out of 45 901 soldiers) and 0·56% for CKD (255 cases out of 45 882 soldiers). Discrete time logistic regression models adjusting for demographic-, military- and healthcare-related covariates showed that sickle cell trait was associated with significantly higher adjusted odds of both AKI [odds ratio (OR): 1·74; 95% confidence interval (CI): 1·17-2·59] and CKD (OR: 2·00; 95% CI: 1·39-2·88). Elevated odds of AKI and CKD were also observed in association with prior CKD and AKI, respectively, and with obesity and prior hypertension. Individuals with sickle cell trait and their providers should be aware of the possibility of increased risk of AKI and CKD to allow for timely intervention and possible prevention.
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http://dx.doi.org/10.1111/bjh.15820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470032PMC
May 2019
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