Publications by authors named "Jiaojiao Gao"

44 Publications

Biocatalyst and colorimetric biosensor of carcinoembryonic antigen constructed via chicken egg white-copper phosphate organic/inorganic hybrid nanoflowers.

J Colloid Interface Sci 2021 May 18;601:50-59. Epub 2021 May 18.

School of Materials Science and Engineering, Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science and Technology, Xi'an 710021, PR China.

In this article, the dual-functional chicken egg white-copper phosphate organic-inorganic hybrid nanoflowers (Cu-NFs), combining the functions of signal amplification and biological recognition, were prepared through a simple one-pot method. The Cu-NFs exhibit excellent biocatalytic activity of peroxidase and polyphenol oxidase. Besides, a biotin-labeled secondary antibody encapsulated Cu-NFs-2 ([email protected]) capture probe was prepared by using the interaction between avidin in the egg white and biotin. Based upon this superiority, the as-prepared Cu-NFs-2 were used in labeled avidin-biotin enzyme-linked immunosorbent assay (Cu-NFs-2 based-LAB-ELISA) to construct a sensitive colorimetric biosensor for the ultrasensitive detection of carcinoembryonic antigen (CEA). Under weak alkaline (pH = 7.5) conditions, the as-developed colorimetric sensor displayed a wide linear range of 0.05-40 ng/mL with a detection limit of 3.52 pg/mL. Furthermore, this colorimetric sensor has been successfully applied to the detection of CEA in human serum samples. Therefore, the as-developed colorimetric sensor has broad application prospects in the field of medical diagnosis and portable detection.
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http://dx.doi.org/10.1016/j.jcis.2021.05.069DOI Listing
May 2021

A novel nonenzymatic ascorbic acid electrochemical sensor based on gold nanoparticals-chicken egg white-copper phosphate-graphene oxide hybrid nanoflowers.

Nanotechnology 2021 May 21;32(32). Epub 2021 May 21.

School of Materials Science and Engineering, Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science and Technology, Xi'an 710021, People's Republic of China.

Au-CEW-Cu(PO)-GO nanoflowers (HNFs), which were assembled of gold nanoparticals (Au NPs), chicken egg white (CEW), copper phosphate (Cu(PO)) and graphene oxide (GO) together to form a flower-like organic/inorganic hybrid nanocomposite, were synthesized through a simple and gentle one-pot co-precipitation method. The prepared samples were well characterized by scanning electron microscope, transmission electron microscope, energy dispersive x-ray spectrometer, x-ray diffraction and Raman spectrometer. The prepared Au-CEW-Cu(PO)-GO HNFs was used to modify glassy carbon electrode to fabricate an electrochemical sensor for detection of ascorbic acid (AA). The electrochemical test results show that the linear range of the developed sensor is 8-300M and the detection limit is 2.67M (S/N = 3). While this sensor displays high sensitivity of 6.01 × 10AMcmand low detection potential of 35 mV due to the combination of the high conductivity of Au NPs, the larger specific surface area of GO and the intrinsic electrocatalytic activity of CEW-Cu(PO)HNFs. Moreover, the Au-CEW-Cu(PO)-GO HNFs-based sensor was successfully developed for application in electrochemical detection of AA in vitamin C tablets.
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http://dx.doi.org/10.1088/1361-6528/abfe28DOI Listing
May 2021

Development of a Ni-Doped VAl Topological Semimetal with a Significantly Enhanced HER Catalytic Performance.

J Phys Chem Lett 2021 Apr 12;12(15):3740-3748. Epub 2021 Apr 12.

Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055, People's Republic of China.

Topological materials with robust topological surface states appear to be well-suited as electrochemical catalysts. However, few studies have been published on the development of non-noble metal topological catalysts, most likely because the topological properties tend to be attributed to the and orbital electrons, while transition-metal catalysis mainly involves orbital electrons. Herein, we proposed a topological semimetallic (TSM) compound, VAl, with a surface state consisting mainly of orbital electrons, as an electrocatalyst for the hydrogen evolution reaction (HER). Density functional theory (DFT) calculations showed that the surface state electrons enhanced the adsorption of H atoms. Moreover, the transfer of surface state electrons between the surface and adsorbed H atoms was optimized through nickel doping. We experimentally prepared single-crystals VAl and VNiAl alloys. Electrochemical analysis showed that not only did VNiAl outperform VAl but also it was among the best non-noble metal topological HER electrocatalysts currently available.
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http://dx.doi.org/10.1021/acs.jpclett.1c00238DOI Listing
April 2021

Association between cold spells and childhood asthma in Hefei, an analysis based on different definitions and characteristics.

Environ Res 2021 04 21;195:110738. Epub 2021 Jan 21.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, China. Electronic address:

Background: As the global climate continues to warm, there is an increased focus on heat, but the role of low temperatures on health has been overlooked, especially for developing countries. Methods We collected the admission data of childhood asthma in 2013-2016 from Anhui Provincial Children's Hospital, as well as meteorological data from the Meteorological Bureau for the study period and collected data of pollutants from 10 monitoring stations around Hefei city. Poisson's generalized additive model (GAM) combined with a distributed lag non-linear model (DLNM) was used to estimate the short-term effects of cold spell on childhood asthma in cold seasons (November to March). 16 definitions of cold spells were clearly compared, which combining 4 temperature indexes (daily minimum and mean temperature; daily minimum and mean apparent temperature), 2 temperature thresholds (2.5th and 5th) and 3 durations of at least 2-4 days. We then have an analysis of the modifying effect of characteristics of cold spells and individuals(gender and age), with a view to discovering the susceptible population to cold spell. Results There was significant association between cold spells and admission risk for childhood asthma. And the definition, in which daily minimum apparent temperature falls below 5th percentile for at least 3 consecutive days, produced the optimum model fit performance. Based on this optimal fit we found that, for the total population, the effect of cold spell lasted approximately five days (lag1-lag5), with the largest effect occurring in lag 3 (RR = 1.110; 95% CI: 1.052-1.170). In subgroup analysis, the cumulative effect of lag0-7 was higher in males and school-age children than in females and other age groups, respectively. In addition, we found that the effect of is higher as the duration increases. Conclusion This study suggests an association between cold spell and childhood asthma, and minimum AT may be a better indicator to define the cold spells. Boys and school-age children are more vulnerable to cold spell. And one of our very interesting findings is that if a cold spell lasts for several days, the impact of the cold spell on those later days is likely to be greater than that of the previous days. In conclusion, we should pay more attention to the protection of boys and school-aged children in our future public health protection and give more attention to those cold spells that last longer. Therefore, we recommend that schools and health authorities need to take targeted measures to reduce the risk of asthma in children during the cold spell.
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http://dx.doi.org/10.1016/j.envres.2021.110738DOI Listing
April 2021

MOF-Derived 2D/3D Hierarchical N-Doped Graphene as Support for Advanced Pt Utilization in Ethanol Fuel Cell.

ACS Appl Mater Interfaces 2020 Oct 8;12(42):47667-47676. Epub 2020 Oct 8.

Flexible Printed Electronics Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.

Development of bifunctional catalysts with low platinum (Pt) content for the ethanol oxidation reaction (EOR) and the oxygen reduction reaction (ORR) is highly desirable, yet challenging. Herein, we present structural engineering of a series of two-dimensional/three-dimensional (2D/3D) hierarchical N-doped graphene-supported nanosized PtCo alloys and Co clusters ([email protected]) via a hydrolysis-pyrolysis route. For the ORR, the optimal [email protected] exhibits a high mass activity of 3.01 A mg, which is comparable to the best Pt-based catalyst obtained through sophisticated synthesis. It also possesses excellent stability with minor decay after 50 000 cyclic voltammograms (CV) cycles in acidic medium. For the EOR, [email protected] achieves the highest mass-specific and area-specific activities of 1.96 A mg and 5.75 mA cm, respectively, among all of the reported EOR catalysts to date. The unique 2D/3D hierarchy, high Pt utilization, and valid encapsulation of nanosized PtCo/Co synergistically contribute to the robust ORR and EOR activities of the present [email protected] A direct ethanol fuel cell based on [email protected] delivers a high open-circuit potential of 0.9 V, a stable power density of 10.5 mW cm, and an excellent rate performance, implying the feasibility of the bifunctional [email protected] This work offers a new strategy for designing an ultralow Pt loading yet highly active and durable catalyst for ethanol fuel cell application.
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http://dx.doi.org/10.1021/acsami.0c15493DOI Listing
October 2020

Elevated environmental PM increases risk of schizophrenia relapse: Mediation of inflammatory cytokines.

Sci Total Environ 2021 Jan 27;753:142008. Epub 2020 Aug 27.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China. Electronic address:

Background: Ecological epidemiology suggests that hospital admissions for schizophrenia are associated with an increased environmental PM, but no prospective study has verified this result, and the physiological mechanism is not clear.

Methods: We used a repeated-measures design to prospectively assess the association of environmental PM and the risk of relapse in schizophrenia, and used two linear mixed-effects models to explore possible mediating effects of immune cytokines on the premise of controlling confounders.

Results: We import the data using EpiData software, and collate and analyze of the data using R software. The increase of PM at lag0 had the greatest impact on the relapse of schizophrenia (for each 10 μg/m increase in PM, the relapse risk score increased by 1.504, that is to say, odds ratio (OR) = 4.500 (95% confidence interval (CI): 2.849-7.106,P < 0.001)), and cumulative effects lasted for four days with the maximum at the second day (for each 10 μg/m increase in PM, the relapse risk score increased by 1.301, OR = 3.673 (95%CI: 1.962-6.876,P < 0.001)). PM exposure was statistically related to four symptom dimensions of early signs scale (ESS), and the symptoms most affected by the increased PM were depression/withdrawal (ESSN) (OR = 1.990, 95%CI: 1.701-2.328), anxiety/agitation (ESS-A) (OR = 1.537, 95%CI: 1.340-1.763), initial psychosis (ESS-IP) (OR = 1.398, 95%CI: 1.151-1.697), and disinhibition (ESS-D) (OR = 1.235, 95%CI: 1.133-1.347). Furthermore, there are three statistically significant pathways in intermediary analysis: of PM and relapse risk: "PM → IL-17 → ESS", "PM → IL-17 → ESS-A", and "PM → IL-17 → ESS-N", and the intermediary ratio of IL-17 was 11.66%, 16.37% and 22.55%, respectively.

Conclusions: Increased environmental PM is a risk factor for the relapse of schizophrenia. Early relapse identification and intervention based on clinical characteristics are of great significance for timely termination of relapse and slowing down of relapse.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142008DOI Listing
January 2021

is a regulator of boundary formation in chrysanthemum ray florets.

Hortic Res 2020 1;7:129. Epub 2020 Aug 1.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Key Laboratory of Landscaping, Ministry of Agriculture and Rural Affairs, College of Horticulture, Nanjing Agricultural University, 210095 Nanjing, China.

Chrysanthemum () is an ideal model species for studying petal morphogenesis because of the diversity in the flower form across varieties; however, the molecular mechanisms underlying petal development are poorly understood. Here, we show that the brassinosteroid transcription factor () in chrysanthemum ( cv. Jinba) is important for organ boundary formation because it represses organ boundary identity genes. Chrysanthemum plants overexpressing displayed increased fusion of the outermost ray florets due to the loss of differentiation of the two dorsal petals, which developed simultaneously with the ventral petals. RNA-seq analysis of the overexpression lines revealed potential genes and pathways involved in petal development, such as (), (), genes encoding MADS-box transcription factors and homeodomain-leucine zippers () and auxin pathway-related genes. This study characterizes the role of in ray floret development by its modulation of flower development and boundary identity genes in chrysanthemum.
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http://dx.doi.org/10.1038/s41438-020-00351-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395151PMC
August 2020

Human adenovirus Coinfection aggravates the severity of Mycoplasma pneumoniae pneumonia in children.

BMC Infect Dis 2020 Jun 16;20(1):420. Epub 2020 Jun 16.

National Clinical Research Center for Respiratory Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Key Laboratory of Pediatric Respiratory Infection diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Mycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate of M. pneumoniae pneumonia (MPP) can reach 52% in some areas, but the effects of coinfection with different pathogens have not been clearly recognized.

Methods: The cases of MPP hospitalized in Beijing Children's Hospital from 1/1/2014 to 12/31/2016 were screened. MPP patients coinfected with Human adenovirus (HAdV) were categorized into the research group. Patients with single M. pneumoniae infection were categorized into the control group, matching the research group by age and admission time with a ratio of 1:3. Clinical manifestations, laboratory examinations, and disease severity were compared between these two groups.

Results: A total of 2540 hospitalized MPP cases were screened in Beijing Children's Hospital, among which thirty cases were enrolled in the research group and ninety cases were enrolled in the control group. The results indicated that patients in the research group had longer hospital stays, longer fever durations and a higher rate of dyspnea, as well as a larger proportion applications of oxygen therapy and noninvasive continuous positive airway pressure (NCPAP). No obvious differences were found in lab examinations within the two groups. Regarding disease severity, the proportions of extremely severe pneumonia and severe disease defined by the clinical score system were higher in the research group than in the control group.

Conclusion: Compared with single M. pneumoniae infection, MPP coinfected with HAdV in children was relatively more serious.
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http://dx.doi.org/10.1186/s12879-020-05152-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296888PMC
June 2020

Association between extreme precipitation and ischemic stroke in Hefei, China: Hospitalization risk and disease burden.

Sci Total Environ 2020 Aug 8;732:139272. Epub 2020 May 8.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: Ischemic stroke is an acute cardiovascular disease with high disability and mortality. Extreme precipitation has been reported to increase the risk of some cardiovascular diseases and further increase the burden of disease. At present, no studies have evaluated the relationship between extreme precipitation and ischemic stroke.

Objective: The aim of this study was to quantitatively analyze the association between extreme precipitation and ischemic stroke hospitalizations and further explore disease burden and its associated susceptible population.

Methods: In this study, we used Poisson generalized linear model combined with distributed lag nonlinear model to investigate the relationship between extreme precipitation (≥95th percentile) and ischemic stroke and further explored the lag effect of extreme precipitation for population with different individual characteristics.

Results: Ischemic stroke hospitalizations were significantly associated with extreme precipitation. The single-day effect occurred on lag 3 (RR = 1.040, 95% CI: 1.058-1.073) lasted until lag 8 (RR = 1.036, 95% CI: 1.004-1.068). The cumulative lag effects of extreme precipitation on ischemic stroke lasted six days (lag 6-lag 11). Male and people aged ≥65 years were more sensitive to extreme precipitation. The attributable fraction (AF) and numbers (AN) of extreme precipitation on hospitalizations for ischemic stroke were 1.38% and 236.4, respectively.

Conclusion: Our study suggested that extreme precipitation may increase the risk of hospital admissions for ischemic stroke, emphasizing the need for society and families to pay more attention to male and people aged ≥65 years.
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http://dx.doi.org/10.1016/j.scitotenv.2020.139272DOI Listing
August 2020

Gastroenteritis exposure and the risk of schizophrenia onset: A systematic review and meta-analysis.

J Psychosom Res 2020 07 11;134:110136. Epub 2020 May 11.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, China. Electronic address:

Objective: The association between gastroenteritis exposure and schizophrenia (SCZ) onset has been investigated, but the findings were inconsistent. This study aimed to determine whether gastroenteritis would increase the risk of SCZ onset.

Methods: We performed a systematic literature search in PubMed, Cochrane Library and the Web of Science database up to 23 November 2019. The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of gastroenteritis on SCZ. Stratified analysis was conducted by study design, diagnostic criteria, region, adjustment for confounders, gastroenteritis sub-classification and data source.

Results: This meta-analysis included nine published articles with 13,830,871 subjects. Overall, there was no significant relationship between gastroenteritis and SCZ onset (N [number of studies] = 11, RR = 1.06, 95% CI: 0.81-1.39). However, pooled results from cohort studies suggested that gastroenteritis significantly increased the risk of SCZ (N = 7, RR = 1.27, 95% CI = 1.05-1.53). Increased risk of SCZ was observed in America (N = 3) and Australia (N = 2), whereas no association was found in Europe (N = 1) and Asia (N = 5). The pooled RR, adjusting for ≥2 confounders (N = 5), was higher than those adjusting for <2 confounders (N = 6). The effects also varied in diagnostic criteria, gastroenteritis sub-classification and data source.

Conclusion: Based on current research evidence, it is not yet certain that gastroenteritis is a risk factor for SCZ, and more research on the association between specific gastroenteritis and SCZ is needed.
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http://dx.doi.org/10.1016/j.jpsychores.2020.110136DOI Listing
July 2020

Super terahertz phase shifter achieving high transmission and large modulation depth.

Opt Lett 2020 May;45(10):2834-2837

We propose an industrial-grade liquid-crystal-based terahertz (THz) 2π-phase shifter with predictable ultra-high amplitude transmittance. The phase retardation reaches 360.5° at 1.68 THz by analyzing the birefringence of liquid crystal (LC), and the amplitude transmittance in 0.3-1.5 THz is over 83%. More than 91.5% transmittance can be reached by decreasing the scattering of the THz wave in the dynamic deflection process of LC molecules, and that is close to the transmittance limit of quartz-based devices. This millimeter-thick phase shifter reaches full phase modulation and ultra-high transmittance in a broad THz band, is easy to be integrated in a quasi-optical system with a compact size and can be utilized as a wave plate, even an element in a THz phased array.
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http://dx.doi.org/10.1364/OL.393571DOI Listing
May 2020

Diurnal temperature range and childhood asthma in Hefei, China: Does temperature modify the association?

Sci Total Environ 2020 Jul 25;724:138206. Epub 2020 Mar 25.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: The present study aimed to understand the effect of diurnal temperature range (DTR) on childhood asthma in Hefei, China, and to explore the effect of temperature on the DTR-asthma association.

Materials And Methods: Daily data on hospital admissions for childhood asthma, air pollutants, and weather variables in Hefei, China, from 1st January 2014 to 31st December 2015, were collected. A generalized additive model combined with a distributed lag non-linear model was used to quantify the effects of DTR on the total, age- and gender-specific hospital admissions for childhood asthma. A non-parametric bivariate response surface model, and a generalized additive model combined with a stratified parametric model were used to explore the interaction between DTR and temperature.

Results: We observed that high DTR was associated with an increase in hospital admissions for childhood asthma. When DTR increased from 6.7 °C to 16.8 °C (99% percentile), hospital admissions for childhood asthma increased by 13% (relative risk: 1.13, 95% confidence interval: 1.07, 1.12). The analysis stratified, by mean temperature level, suggested that when DTR increased by 1 °C at low temperatures, asthma hospitalizations in total children, girls, boys and school-age children increased by 5.0% (95% CI: 2.6%, 7.5%), 3.7% (95% CI: 0.4%, 5.7%), 2.9% (95% CI: 0.8%, 4.4%) and 5.0% (95% CI: 2.6%, 7.5%), respectively.

Conclusions: This study suggests that the impact of high DTR should be considered among public health advice for children with existing asthma. Those days with high DTR and low mean temperature need extra attention.
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http://dx.doi.org/10.1016/j.scitotenv.2020.138206DOI Listing
July 2020

Interactions between climate factors and air quality index for improved childhood asthma self-management.

Sci Total Environ 2020 Jun 7;723:137804. Epub 2020 Mar 7.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China. Electronic address:

Background: Daily air quality index (AQI) forecast can provide early warning information, and it is not clear whether it is appropriate for childhood asthma hospitalizations (CAHs). Furthermore, little is known about the effects of AQI on CAHs, as well as the interactions between temperature, humidity and AQI.

Methods: We collected 32,238 cases in Hefei from 2013 to 2016 and estimated the association between daily CAHs and AQI by combining the Poisson Generalized Linear Models (PGLMs) with the Distributed Lag Nonlinear Models (DLNMs). The interaction between AQI and temperature was tested by stratifying AQI and temperature, as well as humidity.

Results: AQI was associated with an increased risk of hospitalizations for childhood asthma. The adverse effect first appeared on the 3rd day, with the RR of 1.011 (95%CI: 1.000-1.023) and continued until the 19th day of lag (RR = 1.010, 95%CI: 1.001-1.020). In the subgroup analysis, the male and pre-school children were more sensitive to AQI, and there are seasonal differences in the effects of AQI on CAHs. Besides, in a stratified analysis with an AQI of 150, we found synergies between temperature, humidity and AQI. The interaction relative risk (IRR) and relative excess risk due to interaction (RERI) for the interaction between temperature and AQI were 1.157 (95%CI: 1.029-1.306) and 0.122 (95%CI: 0.022-0.223) respectively. For the humidity, the IRR and RERI were 1.090 (95%CI: 1.056-1.206) and 0.083 (95%CI: 0.083-0.143) respectively. Exploring different subgroups in the interaction analyses, it was worth noting that female and pre-school children were more sensitive to the interaction between AQI and temperature, while school-age children were more sensitive to the interaction between AQI and humidity.

Conclusions: The study found that not only AQI can significantly increase the risk of CAHs, but also that under the context of climate change, temperature and humidity have a synergistic effect on AQI, suggesting that considering only the warning information of air pollution is not enough to strengthen the prevention of childhood asthma hospitalization.
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http://dx.doi.org/10.1016/j.scitotenv.2020.137804DOI Listing
June 2020

Efficient terahertz polarization conversion with hybrid coupling of chiral metamaterial.

Opt Lett 2020 Mar;45(5):1276-1279

We propose an ultrathin terahertz waveplate of bi-layer chiral metamaterial for cross-polarization conversion at asymmetric transmission. The chiral metamaterial is constructed with hybrid coupling plasmonic resonators of a concentric ring and a double-split ring. The terahertz metamaterial can efficiently convert the ${y}$y-polarized wave into the ${x}$x-polarized wave with the cross-polarized transmittance over 97% and the polarization conversion ratio of 99% in simulation. The asymmetric transmission parameter, defined by the difference between two opposite propagating transmittances, can be as high as 0.9. The operation frequency and efficiency are geometrically adjustable with the ring size by exploiting the hybrid coupling effect of electric and magnetic resonances. The presented metamaterial enables the functionality of the nonreciprocal terahertz waveplate with high isolation.
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http://dx.doi.org/10.1364/OL.388722DOI Listing
March 2020

Overexpression of CmSOS1 confers waterlogging tolerance in Chrysanthemum.

J Integr Plant Biol 2020 Aug 19;62(8):1059-1064. Epub 2019 Dec 19.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Key Laboratory of Landscaping, Ministry of Agriculture, College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.

The Na /H antiporter SOS1 enhances the salinity tolerance of a number of plant species, but its involvement in the response to hypoxia is less well known. We presented chrysanthemum homologs CmSOS1 and CmRCD1 coordinately mediate waterlogging tolerance by maintaining membrane integrity and minimizing the level of reactive oxygen species.
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http://dx.doi.org/10.1111/jipb.12889DOI Listing
August 2020

Hierarchical Nanoporous VO Nanosheets Anchored with Alloy Nanoparticles for Efficient Electrocatalysis.

ACS Appl Mater Interfaces 2019 Oct 9;11(42):38746-38753. Epub 2019 Oct 9.

School of Materials Science and Engineering , Harbin Institute of Technology , Shenzhen 518055 , China.

Exploring low-cost bifunctional electrocatalysts for efficient water splitting still faces arduous challenges. Herein, a general and straightforward method is developed to prepare 3D hierarchical nanoporous VO nanosheets anchored with different alloy nanoparticles by adopting metal-ion-doped zinc-vanadium (oxy)hydroxides as precursors. To demonstrate this concept, we produced nanoporous VO nanosheets dotted with NiFe alloy nanoparticles through high-temperature reduction and free corrosion. Due to the increased number of active sites, accelerated mass transfer originating from the designed nanoporous architecture, and the metallic property of the VO matrix, the [email protected] hybrid exhibits excellent electrocatalytic performances for both oxygen and hydrogen evolution reactions. When adopting the [email protected] as a bifunctional electrode for overall water splitting, it only requires a cell voltage of 1.56 V to reach 10 mA cm. This work provides a general and practical way to prepare high-efficient and low-cost electrocatalysts.
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http://dx.doi.org/10.1021/acsami.9b13305DOI Listing
October 2019

Association between floods and hospital admissions for schizophrenia in Hefei, China: The lag effects of degrees of floods and time variation.

Sci Total Environ 2020 Jan 28;698:134179. Epub 2019 Aug 28.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: Schizophrenia is a serious mental disorder, endangering 7.5 million patients in China. Floods, as the adverse consequence of temperature-rise, have a negative influence on mental health. However, the relationship between floods and schizophrenia is still insufficient. This study aimed to quantitative the relationship between floods and the admissions for schizophrenia in Hefei, China.

Methods: A Poisson generalized linear model (GLM) combining a distributed lag non-linear model (DLNM) was used to quantify the lag effects of floods on schizophrenia and subgroups (male, female; ≤40 y, >40 y; the married, the unmarried) from 2005 to 2014, Hefei, China. We further explored the effects of different degrees (moderate and severe) of floods and their temporal changes on schizophrenia.

Results: There was a significant association between floods and admissions risk for schizophrenia. And the lag effects for schizophrenia lasted ten days (lag 5-lag 14), with the greatest effect on lag 9 (RR = 1.036, 95% confidence interval (CI): 1.014-1.058). The married, ≤40 y were sensitive to floods. The significant difference wasn't found for genders. The effects of the severe flood were higher than moderate floods, with the largest RR of 1.073 (95%CI: 1.029-1.119). The adverse effects were found in the middle and late period with a decreasing trend in the later period.

Conclusions: This study suggests a significant association between floods and schizophrenia with ten days of lag effects in Hefei, China. Male, female, <40 y and the married are vulnerable to both moderate and severe floods. The findings might be used to allocate medical resources of mental health after floods.
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http://dx.doi.org/10.1016/j.scitotenv.2019.134179DOI Listing
January 2020

Impacts of heat and cold on hospitalizations for schizophrenia in Hefei, China: An assessment of disease burden.

Sci Total Environ 2019 Dec 24;694:133582. Epub 2019 Jul 24.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China. Electronic address:

Background: Compared with risk data (e.g., RR or OR), attributable fraction (AF) provides more information on the formulation of policies and measures in the field of public health. However, to date, existing AF evidence is scarce for the relationship between temperature and the hospitalizations for SCZ.

Objectives: Our primary goal is to estimate the attributable burden of hospitalizations for SCZ related to cold and heat, respectively. Furthermore, to identify vulnerable populations due to heat and cold.

Methods: Poisson generalized linear models combined with DLNMs were used to estimate the association between hospitalizations for SCZ and temperature from 2005 to 2014. The minimum risk temperature (MRT) was used as a reference, to calculate the burden of disease caused by cold and heat.

Results: We found that the majority hospitalizations attributed to heat (70.9%). In different individual levels, men are more sensitive to heat exposure while women are more vulnerable to cold. Among different age groups, the results showed that the attributable risk was slightly higher in the over-40s than in the under-40s. Besides, under different marital conditions, it showed that the unmarried had a little higher attributional risk than the married.

Conclusions: We should pay attention to the impact of heat on hospitalizations for SCZ, especially in those over 40 years old, men and non-married. Our research will provide a basis for policymakers to develop intervention strategies to minimize the impact of adverse temperatures on hospitalizations for SCZ, thereby reducing the burden of disease.
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http://dx.doi.org/10.1016/j.scitotenv.2019.133582DOI Listing
December 2019

Impacts of exposure to humidex on the risk of childhood asthma hospitalizations in Hefei, China: Effect modification by gender and age.

Sci Total Environ 2019 Nov 3;691:296-305. Epub 2019 Jul 3.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China. Electronic address:

Background: With global climate change, there is growing concern about the effects of temperature changes on childhood asthma. However, current research only focuses on the effects of temperature, while ignoring the adverse effects of humidity on children.

Objectives: Our study aimed to quantify the impact of humidex on childhood asthma hospitalizations, which combined temperature and humidity, and further to assess how the effect is modified by individual-factors, such as age and gender.

Methods: Poisson generalized linear models combined with distributed lag nonlinear models were used to estimate the association between daily childhood asthma hospitalizations and humidex from 2013 to 2016. Air pollutions (CO, O and NO) and wind velocity were modelled simultaneously using DLNM, as well as day of week, seasonality and long-term trend.

Results: Low humidex was associated with an increased risk of admissions for asthma in children. The adverse effect appeared on the 4th day, with the RR of 1.045 (95%CI: 1.007-1.084) and lasted until the 7th day (RR: 1.045, 95%CI: 1.006-1.085). Compared with the male, there was an immediate effect on female exposed to low humidex. And the female seems to be more sensitive to low humidex. Besides, the significant effects of humidex on children asthma were detected in the children with preschool and school-age, whereas not for the subgroup of infants. And the school-age children are most sensitive to low humidex.

Conclusions: Low humidex was associated with the increased risk of admissions for childhood asthma in Hefei. Children suffering from asthma should avoid exposure to the low humidex environment, especially in female and school-age children. In addition, the index of humidex was more significant for disease prevention and public health than the average temperature. These findings may provide epidemiology evidence for formulating precaution guidelines to reduce the risk of childhood asthma hospitalizations.
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http://dx.doi.org/10.1016/j.scitotenv.2019.07.026DOI Listing
November 2019

A hyaluronan-based polysaccharide peptide generated by a genetically modified Streptococcus zooepidemicus.

Carbohydr Res 2019 May 23;478:25-32. Epub 2019 Apr 23.

School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing, 210094, China. Electronic address:

Polysaccharide peptides (or protein-bound polysaccharides, PSPs) are commonly found in mushrooms and plants and possess important nutritional properties and health benefits. The pathogenic bacterium Streptococcus zooepidemicus does not inherently produce PSPs but secretes the capsular polysaccharide hyaluronan. However, in a previous investigation of the catalytic mechanism of UDP-glucose dehydrogenase (UGDH), a PSP of peptide-bound hyaluronan was found to be produced by S. zooepidemicus through the in vivo expression of a mutant of the gene encoding UGDH. In the present study, this hyaluronan-derived PSP was structurally characterized by FT-IR, NMR, and high-performance liquid chromatography-mass spectrometry (HPLC-MS), and the data confirmed that the polysaccharide backbone, hyaluronan, is covalently bound to the side-chain peptides via an amide linkage. More importantly, the bacterial production of a PSP via this genetic modification method should inspire further research on the in vitro enzymatic synthesis of PSPs or even naturally occurring polysaccharide derivatives and may provide a theoretical foundation for investigating the in vivo synthetic mechanism of PSPs.
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http://dx.doi.org/10.1016/j.carres.2019.04.005DOI Listing
May 2019

Risk effects of high and low relative humidity on allergic rhinitis: Time series study.

Environ Res 2019 06 19;173:373-378. Epub 2019 Mar 19.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China. Electronic address:

Background: The relationship between environmental factors and allergic rhinitis (AR) has become a focal point recently. However, few studies have investigated the adverse effects of both high relative humidity (RH) and low relative humidity. Moreover, the laged effect and disease burden of RH on AR were also neglected.

Objectives: To explore the association of both high and low RH on daily AR hospital outpatients, and to quantify the corresponding disease burden attributable to RH.

Methods: In our study, we define 95th as high RH and 5th as low RH. A distributed lag non-linear model (DLNM) combined with a Poisson generalized linear regression model were applied to analyze the relationship between RH and hospital outpatients for AR. All patients were retrieved from Anhui Provincial Children's Hospital (n = 37,221) from January 2015 to December 2016. Daily meteorological and air pollutant data were collected by Hefei Meteorological Bureau and Environmental Protection Agency. Subgroup analyses were conducted by gender and occupational groups.

Results: Acute adverse effects of high and low RH on AR were explored respectively, with an increase of daily AR outpatients when encountered high and low RH. The low RH presented a risk effect at current day and lasted up to the eighth day. However, high RH began to appear a risk effect on the fourth day. Notably, the fraction of hospital outpatients attributable to low RH was 5.22% (95% CI: 1.92%, 8.33%) and high RH was 4.07% (95% CI: 1.13%, 7.30%) in the backward perspective. Additionally, male and students apparent to be more sensitive to the effects of low RH.

Conclusion: This study suggests that both high and low RH are potential trigger for AR hospital outpatients in Hefei, China. Our studies might offer valuable messages to health practitioners and useful direction to decisions-makers respectively.
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http://dx.doi.org/10.1016/j.envres.2019.03.040DOI Listing
June 2019

Examining the association between apparent temperature and admissions for schizophrenia in Hefei, China, 2005-2014: A time-series analysis.

Sci Total Environ 2019 Jul 28;672:1-6. Epub 2019 Mar 28.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, China. Electronic address:

Background: Many studies have investigated the association between schizophrenia and daily mean temperature, but the conclusions were not consistent. Apparent temperature (AT), a comprehensive indicator of temperature and humidity, reflected human thermal sensation more objectively than temperature. We aimed to investigate the relationship between high/low AT and schizophrenia hospitalizations in Hefei, China, and further to identify vulnerable subpopulations.

Methods: Poisson generalized linear regression model combined with distributed lag non-linear model (DLNM) was applied to quantify the relationship between AT and schizophrenia hospitalizations, compared with the AT of minimum admissions (3.3 °C). Stratified analysis was conducted by sex, marital status and age. Separate models for AT and temperature were compared as well.

Results: The high AT (90th, 28.3 °C) exerted the greatest effect at lag0, with RR = 1.062 (95%CI, 1.019-1.106). The effect of the low AT (10th, -4.7 °C) was first observed at lag3 (RR = 1.007, 95%CI: 1.000-1.015), and increased to the maximum at lag7 (RR = 1.018, 95%CI: 1.009-1.027). The male patients, the married patients and patients aged 41-60 years appeared to be more vulnerable to both high and low ATs. The values of Akaike Information Criterion and mean squared error (MSE) in model with AT were smaller than that with temperature.

Conclusions: Both high and low ATs were associated with increase in schizophrenia hospitalizations. More protective measures should be taken to avoid adverse AT exposure in susceptible groups.
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.436DOI Listing
July 2019

Metal and Nonmetal Codoped 3D Nanoporous Graphene for Efficient Bifunctional Electrocatalysis and Rechargeable Zn-Air Batteries.

Adv Mater 2019 May 28;31(19):e1900843. Epub 2019 Mar 28.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

Developing bifunctional electrocatalysts with high activities and long durability for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is crucial toward the practical implementation of rechargeable metal-air batteries. Here, a 3D nanoporous graphene (np-graphene) doped with both N and Ni single atoms/clusters is reported. The predoping of N by chemical vapor deposition (CVD) dramatically increases the Ni doping amount and stability. The resulting N and Ni codoped np-graphene has excellent electrocatalytic activities for both the ORR and the OER in alkaline aqueous solutions. The synergetic effects of N and Ni dopants are revealed by density functional theory calculations. The free-standing Ni,N codoped 3D np-graphene shows great potential as an economical catalyst/electrode for metal-air batteries.
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http://dx.doi.org/10.1002/adma.201900843DOI Listing
May 2019

The association between cold spells and admissions of ischemic stroke in Hefei, China: Modified by gender and age.

Sci Total Environ 2019 Jun 1;669:140-147. Epub 2019 Mar 1.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China. Electronic address:

Background: Some studies have discovered that low ambient temperatures were associated with increased risk of the incidence of ischemic stroke. Although the frequency of extreme weather events is increasing, few studies have studied the effects of cold wave on ischemic stroke.

Objective: The purpose of this study was to explore the association between cold waves and ischemic stroke onset and further to explore how this association was modified by cold spell characteristics and individual-level factors.

Methods: A Poisson regression with a distributed lag nonlinear model was used to investigate the association between cold spells under 9 different definitions and daily admissions of ischemic stroke in 2013-2015 in Hefei.

Results: By comparing the attribution risk and the results of the sensitivity analysis of different models, the local optimal cold spell was defined as the day between November to March when daily mean temperature was less than 10th for 2 or more consecutive days (backward attributable risk fraction (b-AF) = 4.19%, 95% empirical confidence intervals (eCI): 0.87%, 6.66%, backward attributable number (b-AN) = 278). On the basis of optimal model, the single-day effect of cold waves on ischemic stroke occurred on 5th day after exposure and continued until 17th day, and the maximum effect appeared on the 5th day with relative risk (RR) = 1.050 (95% confidence interval (CI) = 1.008, 1.094). The significant cumulative effect lasted from day 9 after exposure to cold spells to day 21. The maximum cumulative effect was observed on the 21st day with RR = 2.378 (95% CI = 1.304, 4.337). The female and the young and middle-aged people were susceptible to the local cold waves.

Conclusion: This study suggests that cold spell is a risk factor for ischemic stroke in Hefei, and there is a certain lag effect. Targeted measures should be taken to protect susceptible populations during cold spell days, including women and young and middle-aged people.
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http://dx.doi.org/10.1016/j.scitotenv.2019.02.452DOI Listing
June 2019

Synthesis and coloration of highly dispersive SiO/BiVO hybrid pigments with low cost and high NIR reflectance.

Nanotechnology 2019 Jul 5;30(29):295701. Epub 2019 Mar 5.

School of Materials Science and Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, People's Republic of China. School of Material Science and Engineering, Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, People's Republic of China.

Highly dispersed SiO/BiVO hybrid pigments with a spherical structure and high near-infrared (NIR) reflectance have been successfully fabricated by a facile sol-gel method followed by calcination. The dispersed and uniformly spherical particles of the hybrid pigments were caused by the support provided by SiO microspheres, and their color was adjusted via the band-gap energy, which was changed with the incorporation of SiO microspheres. The SiO/BiVO-3 hybrid pigment presented higher yellow hues (b* = 91.42) and more dispersed spherical particles than other as-prepared hybrid pigments and commercially available BiVO-based yellow pigment. This strategy could save 72 wt% resource of BiVO while yielding the same amount of yellow pigment with high color performance. Therefore, the prepared hybrid pigments not only dramatically decreased the cost of expensive pigments, but also saved scarce resources and reduced environmental pollution. In addition, the SiO/BiVO-3 hybrid pigment also presented high NIR reflective performance, which demonstrated that it would be a favorable candidate for colorful NIR reflective pigments with wide applications in heat insulation.
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http://dx.doi.org/10.1088/1361-6528/ab0ce0DOI Listing
July 2019

UDP-glucose Dehydrogenase: The First-step Oxidation Is an NAD-dependent Bimolecular Nucleophilic Substitution Reaction (S2).

Int J Biol Sci 2019 1;15(2):341-350. Epub 2019 Jan 1.

School of Environmental & Biological Engineering, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing, China, 210094.

UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid by NAD-dependent two-fold oxidation. Despite extensive investigation into the catalytic mechanism of UGDH, the previously proposed mechanisms regarding the first-step oxidation are somewhat controversial and inconsistent with some biochemical evidence, which instead supports a mechanism involving an NAD-dependent bimolecular nucleophilic substitution (S2) reaction. To verify this speculation, the essential Cys residue of UGDH (UGDH) was changed to an Ala residue, and the resulting Cys260Ala mutant and UGDH were then co-expressed via a single-crossover homologous recombination method. Contrary to the previously proposed mechanisms, which predict the formation of the capsular polysaccharide hyaluronan, the resulting strain instead produced an amide derivative of hyaluronan, as validated via proteinase K digestion, ninhydrin reaction, FT-IR and NMR. This result is compatible with the NAD-dependent S2 mechanism.
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http://dx.doi.org/10.7150/ijbs.28904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367545PMC
January 2020

The short-term effects of cold spells on pediatric outpatient admission for allergic rhinitis in Hefei, China.

Sci Total Environ 2019 May 22;664:374-380. Epub 2019 Jan 22.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: Some studies have reported that cold weather is associated with the development of allergic rhinitis (AR), but the study of extreme cold temperatures and AR is scarced. This study was conducted to find out the optimal definition of the cold spells in Hefei and to explore the relationship between cold spells and childhood AR, further to identify potential susceptible populations.

Methods: Data of daily AR, meteorological variables and air pollutants from January 1, 2014 to December 31, 2016 were collected in Hefei. Poisson generalized linear regression with a distributed-lag nonlinear model (DLNM) was used to explore the relationship between cold spells and daily pediatric outpatient with allergic rhinitis, by comparing the number of the admission during the cold spells with those during non-cold spells in cold seasons (December to April), after adjusting for relative humidity, air pollutants, seasonality, long-term trends, calendar month, holiday and day of the week (DOW).

Results: All definitions of cold spells both had a certain impact on children with allergic rhinitis, and the trend of their effects was similar. The optimal cold spells was defined as the daily average temperature for below 10th with two consecutive days during the study period, and the greatest impact of cold spells was at lag0, with a 12.5% (95%CI: 6.3%-19.1%) increase of AR than non-cold spell days, and its impact could last for 2 days. Male children, children aged 5-18 years and non-scattered children were considered to be more vulnerable to AR in cold spell days.

Conclusions: There was evidence showed that the cold spells may significantly increase the pediatric outpatient admission for allergic rhinitis, especially for male children, children aged 5-18 years and non-scattered children. For the serious threat posed by cold spells, caregivers and health practitioners should strengthen their awareness of the prevention of vulnerable people.
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http://dx.doi.org/10.1016/j.scitotenv.2019.01.237DOI Listing
May 2019

Short-term exposure to sulfur dioxide and the risk of childhood hand, foot, and mouth disease during different seasons in Hefei, China.

Sci Total Environ 2019 Mar 2;658:116-121. Epub 2018 Dec 2.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: Sulfur dioxide (SO) is an important component of air pollution, adversely impacting human health worldwide. This study aimed to examine the association between short-term exposure to SO and childhood hand, foot, and mouth disease (HFMD) in Hefei, China.

Methods: A Poisson generalized additive model (GAM) combining the time-series regression analyses was used to fit the SO-HFMD association. The effect of SO was estimated using the single-day lag models (lag0, lag1, lag2) and the moving average lag models (lag01, lag02) We also conducted stratified analyses by season, ages (0-4 years old, 5-14 years old), gender (male, female), childcare patterns (scattered children, kindergarten children) and residence areas (urban, rural). Two-pollutant models were adopted to test the robustness of the results.

Results: There was a statistically significant association between SO and the risk of childhood HFMD. For total cases, the relative risk (RR) at lag0 was 1.038 (95% confidence interval (CI): 1.018-1.057) in whole-period and 1.088 (95% CI: 1.059-1.118) in cold season. During cold season, we observed significant associations between SO and HFMD among all subgroups except for children aged 5-14 years old and the adverse effects occurred on lag0, lag1, lag01, lag02. However, in hot season, SO were significant only for females (lag01 with RR = 1.054; 95%CI = 1.007-1.101) and scattered children (lag01 with RR = 1.054; 95%CI = 1.007-1.101). In general, females and scattered children appeared to be more vulnerable to SO.

Conclusions: This study suggests a significant association between SO and HFMD. especially during cold season. Compared with males and kindergarten children, females and scattered children are at higher risk of developing HFMD.
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http://dx.doi.org/10.1016/j.scitotenv.2018.11.481DOI Listing
March 2019

Ambient concentrations of NO and hospital admissions for schizophrenia.

Occup Environ Med 2019 02 26;76(2):125-131. Epub 2018 Oct 26.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.

Objectives: Schizophrenia is a chronic and severe mental disorder affecting more than 21 million people worldwide. Short-term exposure to nitrogen dioxide (NO) has been associated with hospital admissions (HAs) for mental disorders, but no study has evaluated the specific association of NO and schizophrenia. Additionally, the shape of the concentration-response (C-R) curve has not yet been assessed at present. This study aims to investigate the relationship between short-term exposure to NO and HAs for schizophrenia in Hefei, from 2014 to 2016. We also attempt to explore the C-R and the underlying effect modifiers of the association.

Methods: Daily number of HAs for schizophrenia was derived from the computerised medical record system of Anhui Mental Health Center. We used a time-series Poisson generalised linear regression combined with distributed lag non-linear models to model the NO-schizophrenia relationship.

Results: A total of 11 373 HAs were identified during the study period. An increase in levels of NO was significantly associated with elevated schizophrenia HAs. The estimated relative risk per IQR increase in NO at lag 01 was 1.10 (95% CI 1.01 to 1.18). Greater association was observed in young patients (relative risk: 1.11, 95% CI 1.02 to 1.19). The modelled C-R curves of the NO-schizophrenia relationship suggested possible threshold effects of NO for all ages combined, young patients, men and both seasons.

Conclusions: Short-term exposure to NO may be associated with increased schizophrenia HAs. Findings indicated potential threshold effects of NO, which has important implications for health-based risk assessments.
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http://dx.doi.org/10.1136/oemed-2018-105162DOI Listing
February 2019