Publications by authors named "Jianwei Zheng"

66 Publications

PD-1 inhibitor combined with apatinib modulate the tumor microenvironment and potentiate anti-tumor effect in mice bearing gastric cancer.

Int Immunopharmacol 2021 Oct 31;99:107929. Epub 2021 Jul 31.

Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, People's Republic of China. Electronic address:

Objective: To explore the effect of programmed death 1 (PD-1) inhibitor combined with apatinib on immune regulation and efficacy of the combined therapy in mice bearing gastric cancer (MBGC), and to provide a research basis for enhancing the benefit of immunotherapy in advanced gastric cancer (AGC).

Methods: MBGC were divided into normal saline group (group NS), apatinib group (group A), PD-1 inhibitors group (group B) and PD-1 inhibitors combined with apatinib group (group C). Tumor inhibition rates were calculated. Cytokine levels and expression of immune cells and molecules were detected, and the pathological manifestations of tumor tissues were observed.

Results: Group C had the smallest tumor volume (115.17 ± 16.08 mm) with a tumor inhibition rate of 89.4% ± 0.69%, significantly increased levels of CD4T and CD8T cells in tumor tissues (P < 0.01), the down-regulated proportion of myeloid-derived suppressor cells (MDSCs) (P < 0.01), and levels of PD-1 of CD8T cells (PD-1CD8T) (P < 0.01). There was no difference in the levels of PD-1CD8T, CD4T cells, and MDSCs between groups B and C. Besides, combination therapy increased the levels of interleukin-2 (IL-2), interferon-gamma (IFN-γ), and tumor necrosis factor-ɑ (TNF-ɑ) in tumor tissue and serum. We also found that the anti-angiogenic effect of apatinib increased programmed death ligand-1 (PD-L1) levels, down-regulated vascular endothelial growth factor receptor 2 (VEGFR-2) levels, and induced an increase in the extent of tumor tissue necrosis.

Conclusion: PD-1 inhibitors in combination with apatinib may help improve treatment outcomes and increase survival benefits in patients with AGC.
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http://dx.doi.org/10.1016/j.intimp.2021.107929DOI Listing
October 2021

Probiotics: their action against pathogens can be turned around.

Sci Rep 2021 Jun 24;11(1):13247. Epub 2021 Jun 24.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China.

Probiotics when applied in complex evolving (micro-)ecosystems, might be selectively beneficial or detrimental to pathogens when their prophylactic efficacies are prone to ambient interactions. Here, we document a counter-intuitive phenomenon that probiotic-treated zebrafish (Danio rerio) were respectively healthy at higher but succumbed at lower level of challenge with a pathogenic Vibrio isolate. This was confirmed by prominent dissimilarities in fish survival and histology. Based upon the profiling of the zebrafish microbiome, and the probiotic and the pathogen shared gene orthogroups (genetic niche overlaps in genomes), this consequently might have modified the probiotic metabolome as well as the virulence of the pathogen. Although it did not reshuffle the architecture of the commensal microbiome of the vertebrate host, it might have altered the probiotic-pathogen inter-genus and intra-species communications. Such in-depth analyses are needed to avoid counteractive phenomena of probiotics and to optimise their efficacies to magnify human and animal well-being. Moreover, such studies will be valuable to improve the relevant guidelines published by organisations such as FAO, OIE and WHO.
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http://dx.doi.org/10.1038/s41598-021-91542-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225825PMC
June 2021

Structural insight into [Fe-S-Mo] motif in electrochemical reduction of N over Fe-supported molecular MoS.

Chem Sci 2020 Nov 12;12(2):688-695. Epub 2020 Nov 12.

Wolfson Catalysis Centre, Department of Chemistry University of Oxford Oxford OX1 3QR UK

The catalytic synthesis of NH from the thermodynamically challenging N reduction reaction under mild conditions is currently a significant problem for scientists. Accordingly, herein, we report the development of a nitrogenase-inspired inorganic-based chalcogenide system for the efficient electrochemical conversion of N to NH, which is comprised of the basic structure of [Fe-S-Mo]. This material showed high activity of 8.7 mg mg h (24 μg cm h) with an excellent faradaic efficiency of 27% for the conversion of N to NH in aqueous medium. It was demonstrated that the Fe single atom on [Fe-S-Mo] under the optimal negative potential favors the reduction of N to NH over the competitive proton reduction to H. X-ray absorption and simulations combined with theoretical DFT calculations provided the first and important insights on the particular electron-mediating and catalytic roles of the [Fe-S-Mo] motifs and Fe, respectively, on this two-dimensional (2D) molecular layer slab.
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http://dx.doi.org/10.1039/d0sc04575fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178972PMC
November 2020

Direct Visualization of Substitutional Li Doping in Supported Pt Nanoparticles and Their Ultra-selective Catalytic Hydrogenation Performance.

Chemistry 2021 Aug 9;27(47):12041-12046. Epub 2021 Jul 9.

Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, OX1 3QR, Oxford, UK.

It has only recently been established that doping light elements (lithium, boron, and carbon) into supported transition metals can fill interstitial sites, which can be observed by the expanded unit cell. As an example, interstitial lithium ( Li) can block H filling octahedral interstices of palladium metal lattice, which improves partial hydrogenation of alkynes to alkenes under hydrogen. In contrast, herein, we report Li is not found in the case of Pt/C. Instead, we observe for the first time a direct 'substitution' of Pt with substitutional lithium ( Li) in alternating atomic columns using scanning transmission electron microscopy-annular dark field (STEM-ADF). This ordered substitutional doping results in a contraction of the unit cell as shown by high-quality synchrotron X-ray diffraction (SXRD). The electron donation of d-band of Pt without higher orbital hybridizations by Li offers an alternative way for ultra-selectivity in catalytic hydrogenation of carbonyl compounds by suppressing the facile CO bond breakage that would form alcohols.
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http://dx.doi.org/10.1002/chem.202101470DOI Listing
August 2021

LSCIDMR: Large-Scale Satellite Cloud Image Database for Meteorological Research.

IEEE Trans Cybern 2021 Jun 16;PP. Epub 2021 Jun 16.

People can infer the weather from clouds. Various weather phenomena are linked inextricably to clouds, which can be observed by meteorological satellites. Thus, cloud images obtained by meteorological satellites can be used to identify different weather phenomena to provide meteorological status and future projections. How to classify and recognize cloud images automatically, especially with deep learning, is an interesting topic. Generally speaking, large-scale training data are essential for deep learning. However, there is no such cloud images database to date. Thus, we propose a large-scale cloud image database for meteorological research (LSCIDMR). To the best of our knowledge, it is the first publicly available satellite cloud image benchmark database for meteorological research, in which weather systems are linked directly with the cloud images. LSCIDMR contains 104,390 high-resolution images, covering 11 classes with two different annotation methods: 1) single-label annotation and 2) multiple-label annotation, called LSCIDMR-S and LSCIDMR-M, respectively. The labels are annotated manually, and we obtain a total of 414,221 multiple labels and 40,625 single labels. Several representative deep learning methods are evaluated on the proposed LSCIDMR, and the results can serve as useful baselines for future research. Furthermore, experimental results demonstrate that it is possible to learn effective deep learning models from a sufficiently large image database for the cloud image classification.
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http://dx.doi.org/10.1109/TCYB.2021.3080121DOI Listing
June 2021

High Loading of Transition Metal Single Atoms on Chalcogenide Catalysts.

J Am Chem Soc 2021 Jun 21;143(21):7979-7990. Epub 2021 May 21.

Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, Oxford OX1 3QR, U.K.

Transition metal doped chalcogenides are one of the most important classes of catalysts that have been attracting increasing attention for petrochemical and energy related chemical transformations due to their unique physiochemical properties. For practical applications, achieving maximum atom utilization by homogeneous dispersion of metals on the surface of chalcogenides is essential. Herein, we report a detailed study of a deposition method using thiourea coordinated transition metal complexes. This method allows the preparation of a library of a wide range of single atoms including both noble and non-noble transition metals (Fe, Co, Ni, Cu, Pt, Pd, Ru) with a metal loading as high as 10 wt % on various ultrathin 2D chalcogenides (MoS, MoSe, WS and WSe). As demonstrated by the state-of-the-art characterization, the doped single transition metal atoms interact strongly with surface anions and anion vacancies in the exfoliated 2D materials, leading to high metal dispersion in the absence of agglomeration. Taking Fe on MoS as a benchmark, it has been found that Fe is atomically dispersed until 10 wt %, and beyond this loading, formation of coplanar Fe clusters is evident. Atomic Fe, with a high electron density at its conduction band, exhibits a superior intrinsic activity and stability in CO hydrogenation to CO per Fe compared to corresponding surface Fe clusters and other Fe catalysts reported for reverse water-gas-shift reactions.
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http://dx.doi.org/10.1021/jacs.1c01097DOI Listing
June 2021

Novel core-shell nanocomposite as an effective heterogeneous catalyst for the synthesis of benzimidazoles.

Nanotechnology 2021 Apr 12;32(26):265603. Epub 2021 Apr 12.

College of Science, Northeastern University, Shengyang 110819, People's Republic of China.

Core-shell nanocomposites with a catalytic metal-organic framework (MOF) shell are more effective and stable than bare MOF. We have successfully designed an effective heterogeneous catalyst for the synthesis of benzimidazole by integrating acidic catalytic activity, and promoted the aerobic oxidation and magnetic recyclability of core-shell nanocomposite [email protected]@UiO-66. The [email protected] core is encapsulated by the in situ-grown UiO-66 shell, and the UiO-66 shell retains the porous structure and crystallinity of UiO-66 with abundant exposed Lewis acid sites. It shows high catalytic ability for the synthesis of various benzimidazoles through the acid-catalyzed condensation and aerobic oxidation with in situ oxygen. The [email protected] core provides magnetic recyclability of [email protected]@UiO-66, and maintains high catalytic ability and stability over six cycles.
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http://dx.doi.org/10.1088/1361-6528/abef2fDOI Listing
April 2021

A super learner ensemble of 14 statistical learning models for predicting COVID-19 severity among patients with cardiovascular conditions.

Intell Based Med 2021 17;5:100030. Epub 2021 Mar 17.

Children's Hospital of Orange County, Orange, CA, 92868, United States.

Background: Cardiovascular and other circulatory system diseases have been implicated in the severity of COVID-19 in adults. This study provides a super learner ensemble of models for predicting COVID-19 severity among these patients.

Method: The COVID-19 Dataset of the Cerner Real-World Data was used for this study. Data on adult patients (18 years or older) with cardiovascular diseases between 2017 and 2019 were retrieved and a total of 13 of these conditions were identified. Among these patients, 33,042 admitted with positive diagnoses for COVID-19 between March 2020 and June 2020 (from 59 hospitals) were identified and selected for this study. A total of 14 statistical and machine learning models were developed and combined into a more powerful super learning model for predicting COVID-19 severity on admission to the hospital.

Result: LASSO regression, a full extreme gradient boosting model with tree depth of 2, and a full logistic regression model were the most predictive with cross-validated AUROCs of 0.7964, 0.7961, and 0.7958 respectively. The resulting super learner ensemble model had a cross validated AUROC of 0.8006 (range: 0.7814, 0.8163). The unbiased AUROC of the super learner model on an independent test set was 0.8057 (95% CI: 0.7954, 0.8159).

Conclusion: Highly predictive models can be built to predict COVID-19 severity of patients with cardiovascular and other circulatory conditions. Super learning ensembles will improve individual and classical ensemble models significantly.
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http://dx.doi.org/10.1016/j.ibmed.2021.100030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963518PMC
March 2021

Novel core-shell nanocomposite as an effective heterogeneous catalyst for synthesis of benzimidazoles.

Nanotechnology 2021 Mar 16. Epub 2021 Mar 16.

Jiangxi Key Laboratory of Surface Engineering, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, CHINA.

The core-shell nanocomposite with catalytic metal-organic framework (MOF) shell is more effective and stable than bare MOF. We have successfully designed an effective heterogeneous catalyst for the synthesis of benzimidazole by integrating acidic catalytic activity, promoted aerobic oxidation and magnetic recyclability into core-shell nanocomposite [email protected]@UiO-66. [email protected] core is encapsulated by the in-situ growing UiO-66 shell, and the UiO-66 shell retains the porous structure and crystallinity of UiO-66 with abundant exposed Lewis acid sites, which shows high catalytic ability for the synthesis of various benzimidazole through the acid-catalyzed condensation and aerobic oxidation with in-situ oxygen. The [email protected] core provides magnetic recyclability of [email protected]@UiO-66, which maintains high catalytic ability and stability for 6 cycles.
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http://dx.doi.org/10.1088/1361-6528/abef2fDOI Listing
March 2021

A High-Precision Machine Learning Algorithm to Classify Left and Right Outflow Tract Ventricular Tachycardia.

Front Physiol 2021 25;12:641066. Epub 2021 Feb 25.

Computational and Data Science, Chapman University, Orange, CA, United States.

Introduction: Multiple algorithms based on 12-lead ECG measurements have been proposed to identify the right ventricular outflow tract (RVOT) and left ventricular outflow tract (LVOT) locations from which ventricular tachycardia (VT) and frequent premature ventricular complex (PVC) originate. However, a clinical-grade machine learning algorithm that automatically analyzes characteristics of 12-lead ECGs and predicts RVOT or LVOT origins of VT and PVC is not currently available. The effective ablation sites of RVOT and LVOT, confirmed by a successful ablation procedure, provide evidence to create RVOT and LVOT labels for the machine learning model.

Methods: We randomly sampled training, validation, and testing data sets from 420 patients who underwent successful catheter ablation (CA) to treat VT or PVC, containing 340 (81%), 38 (9%), and 42 (10%) patients, respectively. We iteratively trained a machine learning algorithm supplied with 1,600,800 features extracted our proprietary algorithm from 12-lead ECGs of the patients in the training cohort. The area under the curve (AUC) of the receiver operating characteristic curve was calculated from the internal validation data set to choose an optimal discretization cutoff threshold.

Results: The proposed approach attained the following performance: accuracy (ACC) of 97.62 (87.44-99.99), weighted F1-score of 98.46 (90-100), AUC of 98.99 (96.89-100), sensitivity (SE) of 96.97 (82.54-99.89), and specificity (SP) of 100 (62.97-100).

Conclusions: The proposed multistage diagnostic scheme attained clinical-grade precision of prediction for LVOT and RVOT locations of VT origin with fewer applicability restrictions than prior studies.
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http://dx.doi.org/10.3389/fphys.2021.641066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947246PMC
February 2021

Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.

Can J Physiol Pharmacol 2021 Sep 2;99(9):900-909. Epub 2021 Feb 2.

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, P.R. China.

Vascular endothelial cell senescence is a leading cause of age-associated diseases and cardiovascular diseases. Interventions and therapies targeting endothelial cell senescence and dysfunction would have important clinical implications. This study evaluated the effect of 10 resveratrol analogues, including pterostilbene (Pts) and its derivatives, against endothelial senescence and dysfunction. All the tested compounds at the concentrations from 10 M to 10 M did not show cytotoxicity in endothelial cells by MTT assay. Among the 10 resveratrol analogues, Pts and Pts nicotinate attenuated the expression of senescence-associated β-galactosidase, downregulated p21 and p53, and increased the production of nitric oxide (NO) in both angiotensin II - and hydrogen peroxide - induced endothelial senescence models. In addition, Pts and Pts nicotinate elicited endothelium-dependent relaxations, which were attenuated in the presence of endothelial NO synthase (eNOS) inhibitor L-NAME or sirtuin 1 (SIRT1) inhibitor sirtinol. Pts and Pts nicotinate did not alter SIRT1 expression but enhanced its activity. Both Pts and Pts nicotinate have high binding activities with SIRT1, according to surface plasmon resonance results and the molecular docking analysis. Inhibition of SIRT1 by sirtinol reversed the anti-senescent effects of Pts and Pts nicotinate. Moreover, Pts and Pts nicotinate shared similar ADME (absorption, distribution, metabolism, excretion) profiles and physiochemical properties. This study suggests that the Pts and Pts nicotinate ameliorate vascular endothelial senescence and elicit endothelium-dependent relaxations via activation of SIRT1. These two compounds may be potential drugs for the treatment of cardiovascular diseases related to endothelial senescence and dysfunction.
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http://dx.doi.org/10.1139/cjpp-2020-0583DOI Listing
September 2021

Targeting castration-resistant prostate cancer with a novel ROR antagonist elaiophylin.

Acta Pharm Sin B 2020 Dec 12;10(12):2313-2322. Epub 2020 Jul 12.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Prostate cancer (PCa) patients who progress to metastatic castration-resistant PCa (mCRPC) mostly have poor outcomes due to the lack of effective therapies. Our recent study established the orphan nuclear receptor ROR as a novel therapeutic target for CRPC. Here, we reveal that elaiophylin (Elai), an antibiotic from , is a novel ROR antagonist and showed potent antitumor activity against CRPC and . We demonstrated that Elai selectively binded to ROR protein and potently blocked ROR transcriptional regulation activities. Structure-activity relationship studies showed that Elai occupied the binding pocket with several key interactions. Furthermore, Elai markedly reduced the recruitment of ROR to its genomic DNA response element (RORE), suppressed the expression of ROR target genes and variants, and significantly inhibited PCa cell growth. Importantly, Elai strongly suppressed tumor growth in both cell line based and patient-derived PCa xenograft models. Taken together, these results suggest that Elai is novel therapeutic ROR inhibitor that can be used as a drug candidate for the treatment of human CRPC.
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http://dx.doi.org/10.1016/j.apsb.2020.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745055PMC
December 2020

Prediction of postoperative hematoma occurrence after ultrasound-guided vacuum-assisted breast biopsy in minimally invasive surgery for percutaneous removal of benign breast lesions.

Gland Surg 2020 Oct;9(5):1346-1353

Department of General Surgery, Beijing Chaoyang Hospital Affiliated with Capital Medical University, Beijing, China.

Background: The exact factors and mechanisms involved in the development of hematoma after breast ultrasound (US)-guided vacuum-assisted biopsy (VAB) are not clear. This study aimed to analyze the occurrence, prognosis, and risk factors of hematoma after US-guided VAB for the removal of benign breast lesions.

Methods: This was a retrospective study of consecutive female patients with breast lesions (BI-RADS 3/4a/4b and confirmed as benign by core needle biopsy) removed by percutaneous excisional biopsy by US-guided VAB at the Beijing Chaoyang Hospital from April 2016 to December 2018. Univariable analyses were conducted to identify the factors associated with hematoma (age, nodule size, laterality, nodule location, number of nodules, BI-RADS classification of ultrasound, pathology, breast shape, menstrual period, efficacy time of bandage, and hemostatic agents). Multivariable analysis was performed to identify the factors independently associated with hematoma.

Results: A total of 293 patients (343 breast lesions) were included. Lesion removal was successful in all cases. Hematomas ≥1 cm were found in 39 patients. Finally, 38 (97.4%) hematomas were absorbed completely within 6 months. The multivariable logistic regression analysis revealed that lesion size (P<0.001; OR: 5.775; 95% CI: 2.752-12.121), number of lesions (P=0.011; OR: 3.205, 95% CI: 1.311-7.834), and the efficacy time of bandage 12-24 h (P=0.003; OR: 5.257, 95% CI: 1.792-15.421) were independently associated with hematoma occurrence after US-guided VAB excision of breast lesions. A lesion size cut-off of 23.4 mm (AUC 0.764, 95% CI: 0.692-0.837; 59.0% sensitivity; 80.3% specificity; 77.5% accuracy; P<0.001) could predict hematoma occurrence.

Conclusions: US-guided excisional VAB can effectively remove benign breast lesions. The factors independently associated with postoperative hematoma are lesion size, lesion number, and effective postoperative compression time of bandage.
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http://dx.doi.org/10.21037/gs-20-344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667065PMC
October 2020

Image Denoising Using Sparsifying Transform Learning and Weighted Singular Values Minimization.

Comput Intell Neurosci 2020 4;2020:8392032. Epub 2020 Aug 4.

Zhejiang University of Technology, HangZhou 310023, China.

In image denoising (IDN) processing, the low-rank property is usually considered as an important image prior. As a convex relaxation approximation of low rank, nuclear norm-based algorithms and their variants have attracted a significant attention. These algorithms can be collectively called image domain-based methods whose common drawback is the requirement of great number of iterations for some acceptable solution. Meanwhile, the sparsity of images in a certain transform domain has also been exploited in image denoising problems. Sparsity transform learning algorithms can achieve extremely fast computations as well as desirable performance. By taking both advantages of image domain and transform domain in a general framework, we propose a sparsifying transform learning and weighted singular values minimization method (STLWSM) for IDN problems. The proposed method can make full use of the preponderance of both domains. For solving the nonconvex cost function, we also present an efficient alternative solution for acceleration. Experimental results show that the proposed STLWSM achieves improvement both visually and quantitatively with a large margin over state-of-the-art approaches based on an alternatively single domain. It also needs much less iteration than all the image domain algorithms.
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http://dx.doi.org/10.1155/2020/8392032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439773PMC
July 2021

Effects of a Mind Map-Based Life Review Program on Anxiety and Depressive Symptoms on Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial.

Cancer Nurs 2020 Jul 30. Epub 2020 Jul 30.

Author Affiliations: School of Nursing, Fujian Medical University (Drs Chen, Xiao, and Zheng); and Department of Oncology, Fujian Medical University Union Hospital (Drs Zheng and Lin), Fuzhou, China.

Background: Cancer patients undergoing chemotherapy often experience psychological distress. The mind map-based life review program (MBLRP) offers the potential to reduce patients' negative emotions. However, its effects remain unknown.

Objective: The objective of this study is to determine the effects of the MBLRP on anxiety and depressive symptoms in cancer patients undergoing chemotherapy.

Methods: A randomized controlled trial with repeated measures was adopted. Eighty-four cancer patients undergoing chemotherapy were recruited from a general hospital in Fujian, China. Participants were randomly assigned to an experimental group (n = 40) or a control group (n = 44). The participants in the experimental group received the MBLRP plus routine care. The participants in the control group received routine care. Outcomes were measured at baseline, on the second day, and at 4 weeks after the MBLRP.

Results: In terms of anxiety, multivariate test statistics showed significant differences in within-group (F = 11.343, P < .001), between-group (F = 8.873, P = .004), and interaction effects (group × time) (F = 19.595, P < .001). For the depressive symptoms, the results showed that the within-group effect (F = 12.385, P < .001), group effect (F = 18.000, P < .001), and group × time effect (F = 26.544, P < .001) were statistically significant, favoring the MBLRP experimental group.

Conclusions: The MBLRP has the potential to reduce anxiety and depressive symptoms in cancer patients undergoing chemotherapy. Further research is needed within larger more representative samples.

Implications For Practice: The MBLRP is a nurse-led, nonpharmacological program that could be recommended for cancer patients undergoing chemotherapy and integrated into clinical practice.
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http://dx.doi.org/10.1097/NCC.0000000000000874DOI Listing
July 2020

Measurement of serum intact parathyroid hormone concentration 1 day after total thyroidectomy to assess risk of permanent hypoparathyroidism.

J Int Med Res 2020 Jun;48(6):300060520927199

Department of General Surgery, Beijing Chaoyang Hospital Affiliated with Capital Medical University, Beijing, China.

Objective: This study was performed to assess the clinical value of measuring the intact parathyroid hormone (iPTH) concentration 1 day after total thyroidectomy to estimate the occurrence of permanent hypoparathyroidism (pHPP).

Methods: Data of 546 patients who underwent total thyroidectomy from February 2008 to December 2018 were retrospectively analyzed. Calcium and iPTH concentrations were collected preoperatively and at 1 day and 6 months postoperatively. Logistic regression was used to analyze the correlation between clinical indexes and postoperative pHPP.

Results: Of the 546 patients, 22 (4.03%) developed pHPP. Multivariate analysis showed that the iPTH and serum calcium concentrations measured 1 day after surgery were independent predictors of the risk of pHPP. An iPTH concentration of 5.51 pg/mL measured 1 day postoperatively was used as the cut-off value, and the area under the curve was 0.956. The risk of pHPP was identified with a sensitivity of 100%, specificity of 85.1%, positive predictive value of 22%, and negative predictive value of 100%.

Conclusions: The iPTH concentration measured 1 day after total thyroidectomy is closely related to the occurrence of pHPP postoperatively and is an independent predictive risk factor. The postoperative iPTH concentration can be helpful in identifying patients at risk for developing pHPP.
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http://dx.doi.org/10.1177/0300060520927199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294503PMC
June 2020

Methanol Synthesis at a Wide Range of H /CO Ratios over a Rh-In Bimetallic Catalyst.

Angew Chem Int Ed Engl 2020 Sep 1;59(37):16039-16046. Epub 2020 Jul 1.

Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.

There is increasing interest in capturing H generated from renewables with CO to produce methanol. However, renewable hydrogen production is expensive and in limited quantity compared to CO . Excess CO and limited H in the feedstock gas is not favorable for CO hydrogenation to methanol, causing low activity and poor methanol selectivity. Now, a class of Rh-In catalysts with optimal adsorption properties to the intermediates of methanol production is presented. The Rh-In catalyst can effectively catalyze methanol synthesis but inhibit the reverse water-gas shift reaction under H -deficient gas flow and shows the best competitive methanol productivity under industrially applicable conditions in comparison with reported values. This work demonstrates a strong potential of Rh-In bimetallic composition, from which a convenient methanol synthesis based on flexible feedstock compositions (such as H /CO from biomass derivatives) with lower energy cost can be established.
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http://dx.doi.org/10.1002/anie.202000841DOI Listing
September 2020

Spatial Ensembles of Copper-Silica with Carbon Nanotubes as Ultrastable Nanostructured Catalysts for Selective Hydrogenation.

ACS Appl Mater Interfaces 2020 Jun 4;12(24):27268-27276. Epub 2020 Jun 4.

Department of Chemistry, College of Chemistry and Chemical Engineering, State Key Laboratory of Physical Chemistry for Solid Surfaces, iChEM, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, Xiamen University, Xiamen 361005, China.

Catalyst deactivation is one of the most important issues in heterogeneous catalysis. Constructing a stable nanoscale structure that maintains efficient activity and prolonged stability under redox conditions for catalysis, particularly hydrogenation reactions, remains attractive albeit the flourishing nanoscience. This work presents a facile route to synthesize a semi-encapsulated transition metal by assembling three-dimensional transition metal silicate nanotubes onto carbon nanotubes (CNTs) as precursors. The obtained materials expose an active surface of the transition metal for efficient catalysis and form a specific structure to inhibit the migration of metal nanoparticles (NPs) by establishing strong metal-support interactions. [email protected] prepared by common precipitation shows an inferior activity, and its performance is easily attenuated because of the aggregation of Cu NPs. The addition of CNTs as a carrier doubles the intrinsic activity of Cu catalysts. This hybrid catalyst, which consists of Cu species, SiO, and CNTs, is among the best catalysts for dimethyl oxalate hydrogenation with boosting activity of 25 h and enhanced stability of more than 200 h.
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http://dx.doi.org/10.1021/acsami.0c06763DOI Listing
June 2020

Cetuximab Maintenance Therapy in Patients with Unresectable Wild-Type RAS and BRAF Metastatic Colorectal Cancer: A Single-Institute Prospective Study.

Adv Ther 2020 06 7;37(6):2829-2840. Epub 2020 May 7.

Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, 350001, People's Republic of China.

Introduction: Cetuximab plus FOLFIRI (leucovorin, fluorouracil, and irinotecan) is the preferred first-line therapy for RAS and BRAF wild-type (RBWT) metastatic colorectal cancer (mCRC). To counter chemotherapy-induced side effects, use of maintenance therapy is suggested. Therefore, we evaluated the efficacy and safety of cetuximab maintenance therapy in patients after effective completion of first-line induction therapy.

Methods: This prospective study enrolled untreated patients with mCRC RBWT who received first-line cetuximab plus FOLFIRI therapy. Following this, patients with treatment response either entered observation (stop treatment) or maintenance treatment 1 (cetuximab plus irinotecan) groups. After 6-12 cycles of maintenance treatment 1, patients entered maintenance treatment 2 (cetuximab only). If a patient progressed on maintenance 2, cetuximab plus FOLFIRI was reintroduced. The primary end point was failure-free survival (FFS), whereas the secondary end points included disease control rate (DCR), objective remission rate (ORR), and progression-free survival (PFS). Safety events were also evaluated.

Results: Among 79 enrolled patients, 72 completed first-line treatment effectively (DCR 91.1%, ORR 63.9%) and 44 entered maintenance 1 [median PFS 1 (mPFS, maintenance 1) 6.1 months, 95% confidence interval (CI) 6.0-6.2; DCR 56.8%; ORR 22.7%]. Of them, 21 entered maintenance treatment 2 (mPFS2 8.7 months, 95% CI 3.3-14.1; DCR 28.6%; ORR 4.8%). Median FFS (mFFS) was significantly longer in the maintenance 1 group compared with the observation group [12.7 vs. 3.0 months; hazard ratio (HR) 0.202, 95% CI 0.111-0.369; P < 0.001]. Overall, mFFS was 19.0 and 9.3 months in maintenance and observation groups, respectively (HR 0.211, 95% CI 0.117-0.380; P < 0.001). Rash acneiform, mucositis, and asthenia were commonly observed adverse events during maintenance treatment.

Conclusion: Maintenance treatment with cetuximab after first-line therapy significantly improved FFS, with an acceptable safety profile in untreated patients with mCRC RBWT.

Trial Registration: Retrospectively registered, 2019/10/02, Chinese Clinical Trial Registry, ChiCTR number 1900026360.
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http://dx.doi.org/10.1007/s12325-020-01360-8DOI Listing
June 2020

A 12-Lead ECG database to identify origins of idiopathic ventricular arrhythmia containing 334 patients.

Sci Data 2020 03 23;7(1):98. Epub 2020 Mar 23.

Chapman University, Orange, USA.

Cardiac catheter ablation has shown the effectiveness of treating the idiopathic premature ventricular complex and ventricular tachycardia. As the most important prerequisite for successful therapy, criteria based on analysis of 12-lead ECGs are employed to reliably speculate the locations of idiopathic ventricular arrhythmia before a subsequent catheter ablation procedure. Among these possible locations, right ventricular outflow tract and left outflow tract are the major ones. We created a new 12-lead ECG database under the auspices of Chapman University and Ningbo First Hospital of Zhejiang University that aims to provide high quality data enabling detection of the distinctions between idiopathic ventricular arrhythmia from right ventricular outflow tract to left ventricular outflow tract. The dataset contains 334 subjects who successfully underwent a catheter ablation procedure that validated the accurate origins of idiopathic ventricular arrhythmia.
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http://dx.doi.org/10.1038/s41597-020-0440-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090065PMC
March 2020

Optimal Multi-Stage Arrhythmia Classification Approach.

Sci Rep 2020 02 19;10(1):2898. Epub 2020 Feb 19.

Chapman University, Orange, USA.

Arrhythmia constitutes a problem with the rate or rhythm of the heartbeat, and an early diagnosis is essential for the timely inception of successful treatment. We have jointly optimized the entire multi-stage arrhythmia classification scheme based on 12-lead surface ECGs that attains the accuracy performance level of professional cardiologists. The new approach is comprised of a three-step noise reduction stage, a novel feature extraction method and an optimal classification model with finely tuned hyperparameters. We carried out an exhaustive study comparing thousands of competing classification algorithms that were trained on our proprietary, large and expertly labeled dataset consisting of 12-lead ECGs from 40,258 patients with four arrhythmia classes: atrial fibrillation, general supraventricular tachycardia, sinus bradycardia and sinus rhythm including sinus irregularity rhythm. Our results show that the optimal approach consisted of Low Band Pass filter, Robust LOESS, Non Local Means smoothing, a proprietary feature extraction method based on percentiles of the empirical distribution of ratios of interval lengths and magnitudes of peaks and valleys, and Extreme Gradient Boosting Tree classifier, achieved an F-Score of 0.988 on patients without additional cardiac conditions. The same noise reduction and feature extraction methods combined with Gradient Boosting Tree classifier achieved an F-Score of 0.97 on patients with additional cardiac conditions. Our method achieved the highest classification accuracy (average 10-fold cross-validation F-Score of 0.992) using an external validation data, MIT-BIH arrhythmia database. The proposed optimal multi-stage arrhythmia classification approach can dramatically benefit automatic ECG data analysis by providing cardiologist level accuracy and robust compatibility with various ECG data sources.
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http://dx.doi.org/10.1038/s41598-020-59821-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031229PMC
February 2020

A 12-lead electrocardiogram database for arrhythmia research covering more than 10,000 patients.

Sci Data 2020 02 12;7(1):48. Epub 2020 Feb 12.

Chapman University, Orange, USA.

This newly inaugurated research database for 12-lead electrocardiogram signals was created under the auspices of Chapman University and Shaoxing People's Hospital (Shaoxing Hospital Zhejiang University School of Medicine) and aims to enable the scientific community in conducting new studies on arrhythmia and other cardiovascular conditions. Certain types of arrhythmias, such as atrial fibrillation, have a pronounced negative impact on public health, quality of life, and medical expenditures. As a non-invasive test, long term ECG monitoring is a major and vital diagnostic tool for detecting these conditions. This practice, however, generates large amounts of data, the analysis of which requires considerable time and effort by human experts. Advancement of modern machine learning and statistical tools can be trained on high quality, large data to achieve exceptional levels of automated diagnostic accuracy. Thus, we collected and disseminated this novel database that contains 12-lead ECGs of 10,646 patients with a 500 Hz sampling rate that features 11 common rhythms and 67 additional cardiovascular conditions, all labeled by professional experts. The dataset consists of 10-second, 12-dimension ECGs and labels for rhythms and other conditions for each subject. The dataset can be used to design, compare, and fine-tune new and classical statistical and machine learning techniques in studies focused on arrhythmia and other cardiovascular conditions.
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http://dx.doi.org/10.1038/s41597-020-0386-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016169PMC
February 2020

S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.

Chem Biol Interact 2020 Feb 28;317:108965. Epub 2020 Jan 28.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, PR China; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, Guangdong, 510006, PR China. Electronic address:

Endocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxifen resistance in breast cancer cells and that NSD2 is a potential biomarker of tamoxifen resistant breast cancer. Here, we found that DZNep, an indirect inhibitor of histone methyltransferases, potently induces the degradation of NSD2 protein and inhibits the expression of NSD2 target genes (HK2, G6PD, GLUT1 and TIGAR) involved in the pentose phosphate pathway (PPP). DZNep treatment of tamoxifen-resistant breast cancer cells and xenograft tumors also strongly inhibits tumor growth and the cancer cell survival through decreasing cell production of NADPH and glutathione (GSH) and invoking elevated ROS to cause apoptosis. These findings suggest that DZNep-like agents can be developed to target NSD2 histone methyltransferase for effective treatment of tamoxifen-resistant breast cancer.
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http://dx.doi.org/10.1016/j.cbi.2020.108965DOI Listing
February 2020

Effects of a mind map-based life review programme on psychospiritual well-being in cancer patients undergoing chemotherapy: A randomised controlled trial.

Eur J Cancer Care (Engl) 2020 May 7;29(3):e13221. Epub 2020 Jan 7.

Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, China.

Objectives: To evaluate the effects of a mind map-based life review programme (MBLRP) on psychological distress, hope, meaning in life and self-transcendence in cancer patients undergoing chemotherapy.

Methods: Eighty-four cancer patients undergoing chemotherapy from a university-affiliated hospital in Fujian, China. The participants were randomly allocated to a MBLRP group (n = 40) or usual care group (n = 44). Data were collected at baseline (T0), on the second day (T1) and four weeks after the programme (T2) using the Distress Thermometer, Meaning in Life Questionnaire, Herth Hope Scale and Self-transcendence Scale.

Results: No significant interaction effects for time and group membership were found for psychological distress either at T1 (t = -1.707, p = .090) or at T2 (t = -1.123, p = .263). The interaction effects for T1 and group membership were statistically significant for meaning in life (t = 3.487, p = .001) and hope (t = 5.313, p < .001), but not statistically significant for self-transcendence (t = 0.148, p = .882). The interaction effects for T2 and group membership were statistically significant for meaning in life (t = 2.592, p = .01), hope (t = 5.215, p < .001) and self-transcendence (t = 2.843, p = .005).

Conclusions: The MBLRP could improve hope, meaning in life and self-transcendence in cancer patients undergoing chemotherapy.
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http://dx.doi.org/10.1111/ecc.13221DOI Listing
May 2020

Effect of Hydrotalcites Interlayer Water on Pt-Catalyzed Aqueous-Phase Selective Hydrogenation of Cinnamaldehyde.

ACS Appl Mater Interfaces 2020 Jan 2;12(2):2516-2524. Epub 2020 Jan 2.

Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering , Nanjing Tech University , Nanjing 211816 , China.

The heterogeneous hydrogenation of α,β-unsaturated compounds requires understanding of the structure-activity relationship of metallic catalysts in consideration of solvent-mediated processes. In this work, a CoAl hydrotalcites (CoAl-HTs)-supported Pt nanoparticle catalyst is employed to study the effect of solvent water and HTs interlayer water on the aqueous-phase selective hydrogenation of cinnamaldehyde (CALD). Pt/CoAl-HTs catalyst displays 5075 h of specific reaction rate and 89% of C═O hydrogenation selectivity at 80 °C under 20 bar of H. Combined results of isotope-labeling experiments and theoretical DFT calculations demonstrate that the water-mediated hydrogen-exchange pathway exists in the reaction with a relatively lower-energy barrier in comparison to the direct H-dissociated hydrogenation pathway. The results also reveal that the interlayer water species of HTs support participate in the hydrogen-exchange reaction. Based on the H-D exchange results, these HTs interlayer water species can promote H activation and dissociation processes and thus accelerate the CALD hydrogenation reaction even under solvent-free conditions.
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http://dx.doi.org/10.1021/acsami.9b19160DOI Listing
January 2020

Molecular Profiles and Metastasis Markers in Chinese Patients with Gastric Carcinoma.

Sci Rep 2019 09 30;9(1):13995. Epub 2019 Sep 30.

Fujian Medical University Union Hospital, Fuzhou, 350000, China.

The goal of this work was to investigate the molecular profiles and metastasis markers in Chinese patients with gastric carcinoma (GC). In total, we performed whole exome sequencing (WES) on 74 GC patients with tumor and adjacent normal formalin-fixed, paraffin-embedded (FFPE) tissue samples. The mutation spectrum of these samples showed a high concordance with TCGA and other studies on GC. PTPRT is significantly associated with metastasis of GC, suggesting its predictive role in metastasis of GC. Patients carrying BRCA2 mutations tend not to metastasize, which may be related to their sensitivity to chemotherapy. Mutations in MACF1, CDC27, HMCN1, CDH1 and PDZD2 were moderately enriched in peritoneal metastasis (PM) samples. Furthermore, we found two genomic regions (1p36.21 and Xq26.3) were associated with PM of GC, and patients with amplification of 1p36.21 and Xq26.3 have a worse prognosis (P = 0.002, 0.01, respectively). Our analysis provides GC patients with potential markers for single and combination therapies.
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http://dx.doi.org/10.1038/s41598-019-50171-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769015PMC
September 2019

Photocatalytic water splitting by N-TiO on MgO (111) with exceptional quantum efficiencies at elevated temperatures.

Nat Commun 2019 09 27;10(1):4421. Epub 2019 Sep 27.

Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.

Photocatalytic water splitting is attracting enormous interest for the storage of solar energy but no practical method has yet been identified. In the past decades, various systems have been developed but most of them suffer from low activities, a narrow range of absorption and poor quantum efficiencies (Q.E.) due to fast recombination of charge carriers. Here we report a dramatic suppression of electron-hole pair recombination on the surface of N-doped TiO based nanocatalysts under enhanced concentrations of H and OH, and local electric field polarization of a MgO (111) support during photolysis of water at elevated temperatures. Thus, a broad optical absorption is seen, producing O and H in a 1:2 molar ratio with a H evolution rate of over 11,000 μmol g h without any sacrificial reagents at 270 °C. An exceptional range of Q.E. from 81.8% at 437 nm to 3.2% at 1000 nm is also reported.
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http://dx.doi.org/10.1038/s41467-019-12385-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764948PMC
September 2019

Efficient Non-dissociative Activation of Dinitrogen to Ammonia over Lithium-Promoted Ruthenium Nanoparticles at Low Pressure.

Angew Chem Int Ed Engl 2019 Nov 17;58(48):17335-17341. Epub 2019 Oct 17.

Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.

There is an exciting possibility to decentralize ammonia synthesis for fertilizer production or energy storage without carbon emission from H obtained from renewables at small units operated at lower pressure. However, no suitable catalyst has yet been developed. Ru catalysts are known to be promoted by heavier alkali dopants. Instead of using heavy alkali metals, Li is herein shown to give the highest rate through surface polarisation despite its poorest electron donating ability. This exceptional promotion rate makes Ru-Li catalysts suitable for ammonia synthesis, which outclasses industrial Fe counterparts by at least 195 fold. Akin to enzyme catalysis, it is for the first time shown that Ru-Li catalysts hydrogenate end-on adsorbed N stabilized by Li on Ru terrace sites to ammonia in a stepwise manner, in contrast to typical N dissociation on stepped sites adopted by Ru-Cs counterparts, giving new insights in activating N by metallic catalysts.
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http://dx.doi.org/10.1002/anie.201907171DOI Listing
November 2019

Radiation and host retinoic acid signaling promote the induction of gut-homing donor T cells after allogeneic hematopoietic stem cell transplantation.

Am J Transplant 2020 01 15;20(1):64-74. Epub 2019 Jul 15.

Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Intestinal graft-versus-host disease (GVHD) remains a devastating complication after allogeneic hematopoietic stem cell transplantation (HSCT). Although it has been well established that gut-tropic donor T cells expressing integrin α4β7 are required to cause intestinal damage, the factors that control the induction of this pathogenic T cell population remain to be identified. Retinoic acid (RA) plays an important role in inducing α4β7 expression on T cells. In this study, we showed that gene expression of retinaldehyde dehydrogenase, the key enzyme involved in RA biosynthesis, is significantly increased in the spleen and mesenteric lymph nodes (MLNs) of irradiated mice. In a C57BL/6-into-B6D2F1 allogeneic HSCT model, irradiation significantly increased the induction of α4β7 -donor T cells in mesenteric lymph nodes and spleen. Furthermore, we found that the RA pathway modulates the ability of dendritic cells to imprint gut-homing specificity on alloreactive T cells. We also showed that host dendritic cell RA signaling influences GVHD risk. Our studies identified radiation and recipient RA signaling as 2 primary factors that dictate the magnitude of gut-homing donor T cell induction after allogeneic HSCT. Attenuating radiation-associated inflammation and modulating host RA signaling represent feasible strategies to mitigate intestinal GVHD by reducing gut-seeking pathogenic donor T cells.
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http://dx.doi.org/10.1111/ajt.15501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918002PMC
January 2020
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