Publications by authors named "Jianping Wang"

807 Publications

Effects of Maternal and Progeny Dietary Vitamin E on Growth Performance and Antioxidant Status of Progeny Chicks before and after Egg Storage.

Animals (Basel) 2021 Apr 2;11(4). Epub 2021 Apr 2.

Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, Sichuan, China.

Two trials were conducted to investigate the effects of maternal and progeny dietary vitamin E (VE) supplementation on the growth performance and antioxidant status of offspring before and after egg storage. A total of 576 75-week-old Ross 308 breeder hens were assigned to three dietary VE treatments (100, 200, and 400 mg/kg) with 6 replicates of 32 hens for 12 weeks. Two trials were conducted with offspring hatched from eggs laid at weeks 9 and 12 of breeder feeding trial, respectively. Trial 1 was conducted by a 3 × 2 factorial arrangement of treatments with three levels of maternal dietary VE (100, 200, and 400 mg/kg) and two levels of progeny dietary VE (0 and 35 mg/kg). Trial 2 was conducted with three maternal dietary VE treatment (100, 200, and 400 mg/kg), and chicks were hatched from eggs stored for 14 d and received the same progeny diet with no addition of VE. Results showed that in trial 1, maternal (100, 200, and 400 mg/kg) and progeny (0 and 35 mg/kg) dietary VE supplementation did not affect the growth performance of offspring hatched from unstored eggs ( 0.05). In trial 2, in the case of long-term egg storage, maternal dietary VE supplementation of 200 and 400 mg/kg increased the body weight (BW) of 21- and 42-d-old offspring and the body weight gain (BWG) of offspring from 1 to 21 d ( 0.05), and decreased the feed conversion ratio (FCR) of offspring from 1 to 21 d ( 0.05) compared to 100 mg/kg VE. As the maternal dietary VE levels increased, the liver and serum antioxidant status of offspring enhanced ( 0.05). In conclusion, maternal dietary VE supplementation of 200 or 400 mg/kg could improve the growth performance and anti-oxidant status of offspring hatched from stored eggs, but not for that of offspring hatched from unstored eggs. The suitable VE level for the broiler breeder diet was 400 mg/kg in the case of long-term egg storage.
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http://dx.doi.org/10.3390/ani11040998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066615PMC
April 2021

Dielectric polarization effect and transient relaxation in FAPbBr films before and after PMMA passivation.

Phys Chem Chem Phys 2021 May;23(17):10153-10163

Beijing National Laboratory for Molecular Sciences, Molecular Reaction Dynamics Laboratory, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

In organic-inorganic hybrid ionic lead halide perovskites with a naturally arranged layered structure, the dielectric polarization effect caused by the dielectric mismatch between the organic and inorganic layers takes effect in their optical responses. But this effect has received little attention. Here we used infrared transient spectroscopy to study FAPbBr3 perovskite polycrystalline films before and after PMMA film passivation and found that there is a dielectric polarization effect at the interface between the organic cation layer and the inorganic lattice layer inside the perovskite lattice, and also at the interface between the PMMA film and perovskite film. Due to the dielectric polarization effect and the spatial confinement of the surface electronic (or polaron) state, the luminescence intensity of the passivated perovskite film is significantly enhanced, and the exciton lifetime is greatly increased. Dielectric polarization enhances their efficient transient absorption (TA) and leads to the intramolecular vibration frequency red-shifts, which exhibited the combined relaxation kinetics of the large polaron with dielectric polarization in the perovskite film. Dielectric polarization between the internal lattice and the nanocrystal surface of the perovskite film shows different relaxation processes. The polarization-dependent TA spectrum reveals that the dielectric polarization field causes light-induced anisotropy by changing the chemical bond configurations. These direct TA experimental observations help us to understand the influence of the dielectric polarization effect on the electronic state in various organic-inorganic nanocomposite perovskites.
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http://dx.doi.org/10.1039/d1cp01136gDOI Listing
May 2021

Dietary fiber in a low-protein diet during gestation affects nitrogen excretion in primiparous gilts, with possible influences from the gut microbiota.

J Anim Sci 2021 Apr 19. Epub 2021 Apr 19.

Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, and Animal Nutrition Institute, Sichuan Agricultural University, Wenjiang, Chengdu, People's Republic of China.

We investigated the effects of dietary fiber (DF) supplementation in normal or low crude protein (CP) diets on reproductive performance and nitrogen (N) utilization in primiparous gilts. In total, 77 Landrace × Yorkshire (LY) pregnant gilts were randomly allocated to four dietary treatments in a 2 × 2 factorial design. The groups comprised 1) equal intake of normal CP (12.82% and 0.61% total lysine), 2) low CP (10.53% and 0.61% total lysine), and 3) with or 4) without DF supplementation (cellulose, inulin, and pectin in a 34:10:1 ratio). A low-protein diet during gestation significantly reduced daily weight gain from days 91-110 of pregnancy (-162.5 g/d, P = 0.004). From N balance trials conducted at days 35-38, 65-68, and 95-98 of pregnancy, DF addition increased fecal N excretion at days 65-68 (+24.1%) and 95-98 (+13.8%) of pregnancy (P < 0.05), but reduced urinary N excretion (P < 0.05), resulting in greater N retention at each gestational stage. DF increased fecal microbial protein levels and excretion during gestation. A low CP diet also reduced urinary N excretion at different gestational stages. An in vitro fermentation trial on culture media with non-protein N urea and ammonium bicarbonate (NH4HCO3) as the only N sources revealed that microbiota derived from feces of gestating gilts fed the high DF diet exhibited a greater capacity to convert non-protein N to microbial protein. Microbial fecal diversity, as measured by 16S rRNA sequencing, revealed significant changes from DF, but not CP diets. Gilts fed a low CP diet had a higher number of stillbirths (+ 0.83 per litter, P = 0.046) and a lower piglet birth weight (1.52 kg vs. 1.37 kg, P = 0.006), regardless of DF levels. Collectively, DF supplementation to gestation diets shifted N excretion from urine to feces in the form of microbial protein, suggesting that the microbiota had a putative role in controlling N utilization from DF. Additionally, a low-protein diet during gestation negatively affected the litter performance of gilts.
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http://dx.doi.org/10.1093/jas/skab121DOI Listing
April 2021

Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity.

Phytochemistry 2021 Jun 12;186:112708. Epub 2021 Apr 12.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. Electronic address:

Four undescribed piperazine-2,5-dione derivatives designated janthinolides C-F, and an α-pyrone-containing polyketide namely trichopyrone C, were isolated from the extract of the fungus Penicillium griseofulvum along with four known products. Among them, janthinolide C represents the first naturally occured piperazine-2,5-dione analogue featuring a cleavaged piperazinedione ring with an oxime group, while the structure of janthinolide D possesses a rare N-methoxy group in natural products. Their structures and absolute stereochemistry were elucidated based on spectroscopic data, theoretical NMR and ECD calculations, Snatzke's method, and modified Mosher's method. All compounds were evaluated for in vitro immunosuppression activity in murine splenocytes stimulated by anti-CD3/anti-CD28 mAbs, of which janthinolides B and C showed potential inhibitory activity with IC values at 9.3 and 1.3 μM, respectively.
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http://dx.doi.org/10.1016/j.phytochem.2021.112708DOI Listing
June 2021

Mechanism for the Reaction of White Phosphorus with CpCr(CO) Leading Ultimately to the Triple-Decker Sandwich CpCr(μ-η,η-P): A Theoretical Study.

Inorg Chem 2021 Apr 9;60(8):5955-5968. Epub 2021 Apr 9.

Department of Chemistry and Center for Computational Chemistry, University of Georgia, Athens, Georgia 30602, United States.

The experimentally known reaction of CpCr(CO) with white phosphorus (P) to give CpCr(CO)(η-P), CpCr(CO)(μ-η,η-P), and the triple-decker sandwich CpCr(μ-η,η-P) is of interest since the P reactant having a tetrahedral cluster of four phosphorus atoms is converted to products having P, P, and P ligands. The mechanism of this obviously complicated reaction can be dissected into three stages using a coupled cluster theoretical method that has been benchmarked with the P, Mn(CO), and CpCr(CO) dimerization processes. The first stage of the CpCr(CO)/P reaction mechanism generates the unsaturated singlet intermediate CpCr(CO) that combines with the P reactant. Decarbonylation of the resulting CpCr(CO)(P) complex provides a singlet tetracarbonyl readily fragmenting into the stable triphosphacyclopropenyl complex CpCr(CO)(η-P) and the chromium phosphide CpCr(CO)(P). The isomeric triplet tetracarbonyl CpCr(CO)(P), readily fragments into CpCr(CO)(η-P), which can generate the stable diphosphaacetylene complex CpCr(CO)(η,η-P) as well as the pentamer [CpCr(CO)](P). Combination of the coordinately unsaturated CpCr(CO)(η-P) with CpCr(CO)(η-P) can lead to a ring expansion. This generates the P pentagonal ligand in a CpCr(CO)(P) precursor to the experimentally observed carbonyl-free triple-decker sandwich CpCr(μ-η,η-P) after three successive decarbonylations.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00382DOI Listing
April 2021

Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways.

Toxins (Basel) 2021 03 10;13(3). Epub 2021 Mar 10.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.

Zearalenone (ZEA) is a nonsteroidal estrogenic mycotoxin found in several food commodities worldwide. ZEA causes reproductive disorders, genotoxicity, and testicular toxicity in animals. However, little is known about the functions of apoptosis and autophagy after exposure to ZEA in granulosa cells. This study investigated the effects of ZEA on chicken granulosa cells. The results show that ZEA at different doses significantly inhibited the growth of chicken granulosa cells by inducing apoptosis. ZEA treatment up-regulated Bax and downregulated Bcl-2 expression, promoted cytochrome c release into the cytosol, and triggered mitochondria-mediated apoptosis. Consequently, caspase-9 and downstream effector caspase-3 were activated, resulting in chicken granulosa cells apoptosis. ZEA treatment also upregulated LC3-II and Beclin-1 expression, suggesting that ZEA induced a high level of autophagy. Pretreatment with chloroquine (an autophagy inhibitor) and rapamycin (an autophagy inducer) increased and decreased the rate of apoptosis, respectively, in contrast with other ZEA-treated groups. Autophagy delayed apoptosis in the ZEA-treated cells. Therefore, autophagy may prevent cells from undergoing apoptosis by reducing ZEA-induced cytotoxicity. In addition, our results further show that the autophagy was stimulated by ZEA through PI3K-AKT-mTOR and MAPK signaling pathways in chicken granulosa cells.
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http://dx.doi.org/10.3390/toxins13030199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999718PMC
March 2021

Energy-saving mechanism research on beam-pumping unit driven by hydraulics.

PLoS One 2021 1;16(4):e0249244. Epub 2021 Apr 1.

School of Mechanical Science and Engineering, Northeast Petroleum University, Daqing, Heilongjiang, China.

Aiming to solve the problems of long transmission chain, large movement inertia of components and high energy consumption of pumping units, this proposes a new pumping unit with direct balance and hydraulic drive. Through mathematical modeling and simulation analysis to compare the suspension dynamic characteristics and balance characteristics of the hydraulically driven pumping unit with the conventional one. It turns out that the suspension maximum speed drop 21.14%, the maximum acceleration drops 28.88% and the root mean square torque drops 92.9% on the suspension of the hydraulically driven pumping unit. The experimental results proves that the hydraulically driven pumping unit has significant energy saving efficiency, and achieves more than 30.9% of active power saving rate. Theoretical and practical research results show that hydraulically driven pumping unit is reliable and better energy saving, which provides a basis in theory and engineering practice in application.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249244PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016331PMC
April 2021

Inducing new bioactive metabolites production from coculture of Pestalotiopsis sp. and Penicillium bialowiezense.

Bioorg Chem 2021 May 17;110:104826. Epub 2021 Mar 17.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. Electronic address:

Coculturing two or more fungi is a useful strategy to awaken the silent genes to produce structurally diverse and bioactive natural products. Through the coculture of Pestalotiopsis sp. and Penicillium bialowiezense, six new isoprenylated chromane derivatives, including two pairs of enantiomeric ones (1a/1b-2a/2b) and two optical pure ones (3-4), two new isoprenylated phenol glucoside derivatives (6-7), as well as eight known structural analogues (5 and 8-14), were obtained. The structures of these new compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD calculation. The Δ double bond of pestaloficin D (5) was revised to E-configurated based on the extensive spectroscopic analyses. Compounds 1a/1b and 2a/2b were the first examples of enantiomeric isoprenylated chromane derivatives, which were successfully separated by chiral HPLC. Additionally, all the isolated compounds were evaluated for the in vitro β-glucuronidase (GUS) and butyrylcholinesterase (BChE) inhibitory activities. Compounds 1a and 1b showed significant β-glucuronidase inhibitory potency with IC values of 7.6 and 10.3 μM, respectively. Compound 14 exhibited moderate BChE inhibitory activity with an IC value of 21.3 μM. In addition, the structure-enzyme inhibitory activity relationship of compounds 1-14 is discussed.
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http://dx.doi.org/10.1016/j.bioorg.2021.104826DOI Listing
May 2021

Protective effects of total flavonoids from Qu Zhi Qiao (fruit of Citrus paradisi cv. Changshanhuyou) on OVA-induced allergic airway inflammation and remodeling through MAPKs and Smad2/3 signaling pathway.

Biomed Pharmacother 2021 Jun 19;138:111421. Epub 2021 Mar 19.

Zhejiang You-du Biotech Limited Company, Quzhou 324200, China; Department of Pharmacy, School of Medicine, Zhejiang University City College, 310015 China. Electronic address:

Allergic asthma is one of the inflammatory diseases, which has become a major public health problem. Qu zhi qiao (QZQ), a dry and immature fruit of Citrus paradisi cv. Changshanhuyou, has various flavonoids with pharmacological properties. However, there is a knowledge gap on the pharmacological properties of QZQ on allergic asthma. Therefore, here, we explored the efficacy and mechanism of total flavonoids from QZQ (TFCH) on allergic asthma. We extracted and purified TFCH and conducted animal experiments using an Ovalbumin (OVA)-induced mice model. Bronchoalveolar lavage fluid and Swiss-Giemsa staining were used to count different inflammatory cells in allergic asthma mice. We conducted histopathology and immunohistochemistry to evaluate the changes in the lungs of allergic asthma mice. Moreover, we used ELISA assays to analyze chemokines and inflammatory cytokines. Furthermore, western blot analyses were conducted to elucidate the mechanism of TFCH on allergic asthma. We established that TFCH has anti-inflammatory effects and inhibits airway remodeling, providing a potential therapeutic strategy for allergic asthma.
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http://dx.doi.org/10.1016/j.biopha.2021.111421DOI Listing
June 2021

Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity.

J Anim Sci Biotechnol 2021 Mar 9;12(1):43. Epub 2021 Mar 9.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Key laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs, Key laboratory of Animal Disease-resistant Nutrition of Sichuan Province, Institute of Animal Nutrition, Sichuan Agricultural University, No. 211, Gongpinghuimin Road, Wenjiang District, Chengdu, 611130, Sichuan Province, People's Republic of China.

Background: Lentinan (LNT) may regulate many important physiological functions of human and animals. This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs.

Methods: Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d (n = 14). RV infection was executed on d 15. After extracting polysaccharides from LNT product, its major monosaccharides were analyzed. Then, LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells.

Results: Dietary LNT supplementation supported normal function of piglets even when infected with RV, as reflected by reduced growth performance loss and diarrhea prevalence, and maintained gut immunity (P < 0.05). The polysaccharide was isolated from LNT product, which molecular weight was 5303 Da, and major monosaccharides included glucose, arabinose and galactose. In RV-infected IPEC-J2 cells, this polysaccharide significantly increased cell viability (P < 0.05), and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides (P < 0.05).

Conclusion: Those results suggest that LNT administration increases the piglets' resistance to RV-induced stress, likely by supporting intestinal immunity.
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http://dx.doi.org/10.1186/s40104-021-00562-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945689PMC
March 2021

A systematic review of noninferiority margins in oncology clinical trials.

J Comp Eff Res 2021 Apr 17;10(6):443-455. Epub 2021 Mar 17.

Janssen Global Services, LLC, Raritan, NJ 08869, USA.

A systematic literature review was conducted to identify and characterize noninferiority margins for relevant end points in oncology clinical trials. Randomized, controlled, noninferiority trials of patients with cancer were identified in PubMed and Embase. Of 2284 publications identified, 285 oncology noninferiority clinical trials were analyzed. The median noninferiority margin was a hazard ratio of 1.29 (mean: 1.32; range: 1.05-2.05) for studies that reported time-to-event end points (n = 192). The median noninferiority margin was 13.0% (mean: 12.7%; range: 5.0-20.0%) for studies that reported response end points as absolute rate differences (n = 31). Although there was consistency in the noninferiority margins' scale, variability was evident in noninferiority margins across trials. Increased transparency may improve consistency in noninferiority margin application in oncology clinical trials.
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http://dx.doi.org/10.2217/cer-2020-0200DOI Listing
April 2021

Highly Efficient Cool-White Photoluminescence of (Gua)CuI Single Crystals: Formation and Optical Properties.

ACS Appl Mater Interfaces 2021 Mar 14;13(11):13443-13451. Epub 2021 Mar 14.

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Zero-dimensional lead-free organic-inorganic hybrid metal halides have drawn attention as a result of their local metal ion confinement structure and photoelectric properties. Herein, a lead-free compound of (Gua)CuI (Gua = guanidine) with a different metal ion confinement has been discovered, which possesses a unique [CuI] face-sharing tetrahedral dimer structure. First-principles calculation demonstrates the inherent nature of a direct band gap for (Gua)CuI, and its band gap of ∼2.98 eV was determined by experiments. Worthy of note is that (Gua)CuI exhibits a highly efficient cool-white emission peaking at 481 nm, a full-width at half-maximum of 125 nm, a large Stokes shift, and a photoluminescence quantum efficiency of 96%, originating from self-trapped exciton emission. More importantly, (Gua)CuI single crystals have a reversible thermoinduced luminescence characteristic due to a structural transition scaled by the electron-phonon coupling coefficients, which can be converted back and forth between cool-white and yellow color emission by heating or cooling treatment within a short time. In brief, as-synthesized (Gua)CuI shows great potential for application both in single-component white solid-state lighting and sensitive temperature scaling.
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http://dx.doi.org/10.1021/acsami.1c02503DOI Listing
March 2021

Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis .

Int J Mol Med 2021 May 11;47(5). Epub 2021 Mar 11.

Department of Radiation Protection, Institute of Radiation Medicine, Fudan University, Shanghai 200032, P.R. China.

Irradiation‑induced bone remodeling imbalances arise as a consequence of the dysregulation of bone formation and resorption. Due to the abundance of osteocytes, their long life and their dual‑regulatory effects on both osteoblast and osteoclast function, they serve as critical coordinators of bone remolding. In the present study, femur and tibia‑derived primary osteocytes were cultured and irradiated to observe the functional changes and the cellular senescence phenotype . Irradiation directly reduced cell viability, affected the crucial dendritic morphology and altered the expression of functional proteins, including upregulation of receptor activator of nuclear factor‑κB ligand and sclerostin, and downregulation of osteoprotegerin. Irradiated osteocytes were shown to exhibit notable DNA damage, which resulted in the initiation of a typical cellular senescence phenotype. Furthermore, it was found that irradiation‑induced prematurely senescent osteocytes stimulate molecular secretion, referred to as senescence‑associated secretory phenotype (SASP), which may be involved in modulation of the bone microenvironment, including the promotion of osteoclastogenesis. Taken together, the results showed that irradiation triggered osteocyte senescence and the acquisition of an associated secretory phenotype. This further resulted in an imbalance of bone remodeling through senescent influence on proliferation, morphology and marker protein production, but also indirectly via a paracrine pathway through SASP secretion. The results of the present study may highlight the potential of SASP‑targeted interventions for the management of radiation‑induced bone loss.
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http://dx.doi.org/10.3892/ijmm.2021.4909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949628PMC
May 2021

Responses of Vaginal Microbiota to Dietary Supplementation with Lysozyme and its Relationship with Rectal Microbiota and Sow Performance from Late Gestation to Early Lactation.

Animals (Basel) 2021 Feb 24;11(3). Epub 2021 Feb 24.

College of Food Science, Sichuan Agricultural University, Ya'an 625014, China.

This study was conducted to evaluate the effects of dietary lysozyme (LZM) supplementation on the vaginal microbiota, as well as the relationship between vaginal microbiota and the fecal microbiota of rectum and the reproductive performance of the sow. A total of 60 Yorkshire × Landrace sows (3-6 of parity) were arranged from day 85 of gestation to the end of lactation in a completely randomized design with three treatments (control diet, control diet + lysozyme 150 mg/kg, control diet + lysozyme 300 mg/kg). The results showed that sows fed with lysozyme increased serum interleukin-10 (IL-10, < 0.05) on day 7 of lactation. The vaginal microbiota varied at different taxonomic levels with LZM supplementation by 16S rRNA gene sequencing. The most representative changes included a decrease in Tenericutes, , and increase in Bacteroidetes, Actinobacteria, , and ( < 0.05). There were 777 OTUs existing in both, vaginal and fecal microbiota. The addition of LZM also decreased the abundance of Tenericutes ( < 0.05) in the vagina and feces. The changes in the microbiota were correlated in some cases positively with the performance of the sow, for example, in feces was positively correlated with the neonatal weight ( < 0.05). These results indicate that the addition of lysozyme to the diet of sow during perinatal period promote the change of vaginal bacterial community after farrowing. The variations in vaginal microbiota are also associated with the changes in the fecal microbiology of the rectum and the reproductive performance of the sow. Therefore, it is concluded that dietary supplementation with lysozyme in sows in late gestation stage until early lactation, is beneficial to establish vaginal microbiota that seems to promote maternal health and reproductive performance.
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http://dx.doi.org/10.3390/ani11030593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996156PMC
February 2021

The left-side bias is not unique to own-race face processing.

Atten Percept Psychophys 2021 May 24;83(4):1562-1570. Epub 2021 Feb 24.

Department of Psychology, Zhejiang Normal University, Jinhua, 321001, China.

Humans show a clear left-side bias in face processing. A chimeric face constructed with the left side (from the viewer's perspective) of a face and its mirror image is usually rated as more resemblant to the original face than a chimeric face constructed with the right side of the same face. Previous studies have characterized the left-side bias mainly with own-race faces, but it remains unclear whether this effect is race specific or if it reflects an universal visual expertise. One hundred and five Chinese students completed two versions of a chimeric face-identification task. The results revealed a significant left-side bias for both own-race (Chinese) and other-race (Caucasian) faces, suggesting that the left-side bias reflects an universal visual expertise in face processing.
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http://dx.doi.org/10.3758/s13414-021-02264-7DOI Listing
May 2021

Dietary apple pectic oligosaccharide improves reproductive performance, antioxidant capacity, and ovary function of broiler breeders.

Poult Sci 2021 Apr 7;100(4):100976. Epub 2021 Jan 7.

College of Agriculture and Forestry, Pu'er Unviersity, Pu'er City 665000, China. Electronic address:

Reproduction performance is one of the most important economic traits for the poultry industry. Intriguingly, apple pectic oligosaccharide (APO) could promote gastrointestinal function and immune function to improve performance; however, literature about APO on reproduction performance in breeders is limited. This study aimed to determine whether APO administration can improve reproduction performance and ovary function of broiler breeders with different egg laying rates. Two hundred and fifty six Arbor Acres broiler breeders (48-week-old) were used in a 2 × 2 factorial design with 2 egg laying rates (average [AR] and low [LR]) and 2 dietary levels of APO (0 and 200 mg/kg APO). Results showed that the LR breeders presented higher egg weight but lower egg laying rate, qualified egg rate, and feed efficiency than the AR breeders (P < 0.05). Also, the LR breeders had decreased serum Anti-Müllerian hormone, leptin, and antioxidant enzyme (superoxide dismutase, total antioxidant capacity) levels than the AR breeders (P ≤ 0.05). Dietary supplementation with APO improved egg weight, feed efficiency, as well as egg albumen quality (higher albumen height and Haugh unit) (P < 0.05), and decreased the concentration of pro-inflammatory cytokine levels (interleukin [IL]-1β, IL-8) in serum (P ≤ 0.05). The apoptosis rate and pro-apoptosis-related gene expression (caspase 9 and Bax) in the ovary of LR breeders were higher, while the anti-apoptosis-related gene expression (Bcl-2, PCNA) was lower in LR compared with the AR breeders (P < 0.05). Dietary supplementation with APO decreased the caspase 9 and Bax expression in LR breeders (P < 0.05), and increased the Bcl-2 and PCNA expression in the 2 breeders (P < 0.05). These findings indicate that breeders with a lower egg laying rate exhibit lower antioxidant capacity and high cell apoptosis in the ovary. Dietary supplementation with APO might improve albumen quality and antioxidant capacity, and decrease the inflammatory factors and ovary apoptosis-related genes expression to improve ovary function. Moreover, the effect of APO on decreasing ovarian pro-apoptosis-related gene expression was more pronounced in lower reproductive breeders.
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http://dx.doi.org/10.1016/j.psj.2020.12.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900577PMC
April 2021

Effect of Tumor Size on Long-Term Survival After Resection for Solitary Intrahepatic Cholangiocarcinoma.

Front Oncol 2020 21;10:559911. Epub 2021 Jan 21.

Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: The relationship between tumor size and survival in intrahepatic cholangiocarcinoma (ICC) is still controversial. This study aimed to evaluate the prognostic ability of tumor size for solitary ICC after resection and explore optimal cut-off values in different subgroups.

Methods: Patients with solitary ICC who underwent liver resection from the Surveillance, Epidemiology, and End Results Program and Shandong Provincial Hospital were retrospectively analyzed. Kaplan-Meier and Cox regression analysis were used to assess the prognostic ability of tumor size. The log-rank test was used to determine the optimal cut-off values, and a minimum P was regarded as the optimal one in different subgroups.

Results: Large tumor size groups had worse overall survival (OS) than small tumor size groups. Cox regression analysis suggested that tumor size was an independent prognostic factor for OS for solitary ICC after resection. Subgroup analysis showed tumor size was associated with OS for both solitary ICC with and without vascular invasion (VI). Furthermore, the optimal cut-off values for solitary ICC with and without VI were found to be 8 and 3 cm, respectively, which could divide the patients into two groups with significant differences in OS.

Conclusion: Tumor size was an independent prognostic factor for solitary ICC after resection. The existing American Joint Committee on Cancer (AJCC) staging system could be improved if the cut-off value of the T1 stage was changed to 8 cm and if the T2 stage incorporated a tumor size with a cut-off value of 3 cm. Further studies with more cases are needed to validate these findings.
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http://dx.doi.org/10.3389/fonc.2020.559911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859518PMC
January 2021

Five new secondary metabolites from the fungus Phomopsis asparagi.

Fitoterapia 2021 Jan 31;150:104840. Epub 2021 Jan 31.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China. Electronic address:

Five new compounds, including a pair of diphenylcyclopentenone enantiomers (±)-phomopsisin A (1), a sesquiterpenoid 15-hydroxylithocarin A (2), a new diketopiperazine alkaloid prenylcyclotryprostatin A (3) and 7-hydroxy-cis-L(-)-3,6-dibenzyl-2,5-dioxopiperazine (6), along with five known compounds were isolated from the fungus Phomopsis asparagi. Their structures were elucidated on the basis of spectroscopic analyses (1D and 2D NMR), theoretical electronic circular dichroism (ECD) calculation, modified Mosher's method, and X-ray crystallography. The racemates of (±)-phomopsisin A showed inhibition on α-glucosidase with IC of 30.07 ± 0.75 μM (positive control acarbose, 121 ± 2.7 μM).
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http://dx.doi.org/10.1016/j.fitote.2021.104840DOI Listing
January 2021

The effect of dietary pectic oligosaccharide supplementation on intestinal health of broiler breeders with different egg-laying rates.

Poult Sci 2021 Mar 6;100(3):100938. Epub 2021 Jan 6.

Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Key laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs, Key laboratory of Animal Disease-resistant Nutrition of Sichuan Province, Chengdu 611130, People's Republic of China. Electronic address:

This study was conducted to explore whether dietary pectic oligosaccharide (POS) supplementation could improve gut health of broiler breeders with different egg-laying rates. A 2 × 2 factorial design was used in this study. Two hundred fifty-six Arbor Acres broiler breeders (48 wk of age), including 128 average egg-laying rate and 128 low egg-laying rate (LELR) birds, were randomly fed with the diets supplemented with or without 200 mg kg of POS (n = 8). The trial lasted for 8 wk. Compared with average egg-laying rate broiler breeders, LELR broiler breeders had lower laying rate and qualified egg rate (P < 0.05), higher egg weight and feed conversion ratio (P < 0.05), higher malondialdehyde (MDA) levels in the jejunum (P < 0.05), higher IL-6 (P < 0.05) and tumor necrosis factor α (TNF-α) (P = 0.07) mRNA expressions in the jejunal mucosa, and lower microflora diversity in cecal digesta. Dietary POS supplementation increased egg weight of broiler breeders (P < 0.05), enhanced superoxide dismutase activity in the jejunum (P < 0.05), decreased MDA level in the jejunum (P < 0.05), upregulated zonula occluden 1 mRNA expression in the jejunal mucosa (P < 0.05), downregulated IL-6 and TNF-α mRNA expressions in the jejunal mucosa (P < 0.05), and regulated relative abundance of some microbiota (including the phylum and genus, P < 0.05). In addition, in LELR broiler breeders, POS administration enhanced villus height (P = 0.08) and ZO-2 mRNA expression (P = 0.09) in the jejunal mucosa, alleviated the increasing MDA level in the jejunum (P < 0.05) and IL-6 and TNF-α mRNA expressions in the jejunal mucosa (P < 0.05), and regulated relative abundance of some microbiota (including the phylum and genus, P < 0.05). These results suggest that supplementing POS in diets may elevate gut health via improvement of intestinal barrier function, antioxidant capacity, and microbiota composition in broiler breeders with different egg-laying rates.
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http://dx.doi.org/10.1016/j.psj.2020.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936170PMC
March 2021

Differential analysis of gut microbiota and the effect of dietary Enterococcus faecium supplementation in broiler breeders with high or low laying performance.

Poult Sci 2021 Feb 31;100(2):1109-1119. Epub 2020 Oct 31.

Research Center of Tea and Tea Culture, College of Agronomy, Jiangxi Agricultural, University, Nanchang, 330045, P.R. China. Electronic address:

The difference in microbiota was examined for breeders with different egg-laying rates, and the impact of dietary Enterococcus faecium (EF) was also determined in the present study. A total of 256 Arbor Acres broiler breeders (48-wk-old) were used in a 2 × 2 factorial design, which encompassed 2 egg-laying rate levels [average (average egg laying: AP, 80.45 ± 0.91%) and low (lower egg laying: LP, 70.61 ± 1.16%)] and 2 different dietary groups [control (no additive), 6 × 10 cfu/kg EF]. The results showed that the AP breeders presented a lower egg weight, feed conversion ratio, abdominal fat rate, and serum leptin level (P ≤ 0.05) as well as a higher egg-laying rate (P < 0.01) than the LP breeders. Dietary supplementation with EF improved the egg weight (P = 0.03) and had a higher concentration of follicle-stimulating hormone (FSH) in the serum (P = 0.04). The relative expression of Caspase 9, Bax, AMHR, BMP15, and GATA4 in the ovary of AP breeders was lower, whereas the FSHR and BMPR1B expression was higher than that measured in LP breeders (P ≤ 0.05). LP increased the abundance of Bacteroidetes (phylum), Firmicutes (phylum), Bacteroidia (class), Clostridia (class), Bacteroidales (order), Clostridiales (order), and Lachnospiraceae (family), whereas the AP promoted the enrichment of Proteobacteria (phylum) and Gammaproteobacteria (class) (P < 0.05). The genera Bacillus, Rhodanobacter, and Streptomyces were positively correlated with the egg-laying rate and BMPR1B expression (P < 0.05) but negatively correlated with the abdominal fat rate (P < 0.05) and Caspase 9 (P < 0.05). These findings indicate that the low reproductive performance breeders had lower microbiota diversity and higher Firmicutes, which triggers the energy storage that led to higher fat deposition. Besides, increases in the abdominal fat rate, leptin level, and apoptosis (Caspase 9, Bax) and reproduction-related gene (BMP15, AMHR, BMPR1B, and GATA4) expression would possibly be the potential mechanisms under which breeders have different reproductive performance. Dietary EF increased the egg weight and serum FSH level and decreased the Bacteroidetes (phylum) in low reproductive breeders.
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http://dx.doi.org/10.1016/j.psj.2020.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858034PMC
February 2021

Density and distribution of lymphocytes in pretherapeutic rectal cancer and response to neoadjuvant therapy.

Gastroenterol Rep (Oxf) 2020 Dec 12;8(6):445-452. Epub 2020 Jun 12.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.

Background: Lymphocytic density in rectal cancer has been reported to be associated with therapeutic response, but the role of the lymphocytic distribution pattern remains to be determined. This study aimed to evaluate the association between the distribution and density of lymphocytes in rectal-cancer tissue with tumor response to neoadjuvant therapy.

Methods: We retrospectively analysed 134 patients with rectal cancer receiving neoadjuvant therapy within a prospectively maintained cohort. Pretherapeutic biopsy samples were stained with immunohistochemistry (CD4 and CD8). Densities of intratumoral periglandular lymphocytes (IPLs) and tumor-infiltrating lymphocytes (TILs) were assessed separately. Logistic-regression analysis was used to assess associations of lymphocyte densities with tumor regression grade (TRG), controlling for clinicopathological, molecular, and regimen features.

Results: Compared with cases in the lowest quartile of CD8 TILs, those in the highest quartile were significantly associated with better TRG (multivariate odds ratio, 0.23; 95% confidence interval, 0.07 to 0.76; <0.001). In contrast, CD8 IPLs, CD4 IPLs, and CD4 TILs were not significantly associated with TRG (=0.033, 0.156, and 0.170, respectively). Sensitivity analyses detected no interaction between CD8 TILs and regimen of neoadjuvant radiation (=0.831) or chemotherapy (=0.879) on TRG.

Conclusions: Our data suggest that CD8 TILs, but not IPLs, are independently associated with response to neoadjuvant therapy, regardless of the regimen of radiation or chemotherapy.
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http://dx.doi.org/10.1093/gastro/goaa016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793145PMC
December 2020

Tea bioactive components prevent carcinogenesis via anti-pathogen, anti-inflammation, and cell survival pathways.

IUBMB Life 2021 Feb 29;73(2):328-340. Epub 2021 Jan 29.

Animal Nutrition Institute, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Key Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Chengdu, China.

Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improvements in human health. Tea contains many active components, including tea polyphenols, tea polysaccharides, L-theanine, tea pigments, and caffeine among other common components. Several studies have identified components in tea that can directly or indirectly reduce carcinogenesis with some being used in a clinical setting. Many previous studies, in vitro and in vivo, have focused on the mechanisms that functional components of tea utilized to protect against cancer. One particular mechanism that has been well described is an improvement in antioxidant capacity seen with tea consumption. However, other mechanisms, including anti-pathogen, anti-inflammation and alterations in cell survival pathways, are also involved. The current review focuses on these anti-cancer mechanisms. This will be beneficial for clinical utilization of tea components in preventing and treating cancer in the future.
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http://dx.doi.org/10.1002/iub.2445DOI Listing
February 2021

Dietary supplementation of 25-hydroxycholecalciferol increases tibial mass by suppression bone resorption in meat ducks.

Anim Nutr 2020 Dec 20;6(4):467-479. Epub 2020 Sep 20.

Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.

Leg problems often result from the rapid weight gain and poor bone quality in modern ducks, leading to a high risk of fractures and continuous pain. We hypothesized that improving bone quality in combination with delaying weight gain via a low nutrient density (LND) diet probably reverses these skeletal abnormalities. Studies indicated that 25-hydroxycholecalciferol (25-OH-D), a vitamin D metabolite, is effective in treating bone-related disorders. Therefore, Exp. 1 evaluated the effects of 25-OH-D on tibial mass of meat ducks. Male meat ducklings were fed a standard nutrient density diet (containing a regular vitamin regimen) without or with 25-OH-D at 0.069 mg/kg for 35 d. The results showed that 25-OH-D supplementation improved the mineral content, microarchitecture and mechanical properties of tibias, and this companied by a decreased serum bone resorption marker and a concomitant decrement in osteoclast-specific marker genes expression. Subsequently, Exp. 2 was conducted to examine the impacts of 25-OH-D incorporating an LND diet on tibial quality of ducks under 2 different vitamin regimens (regular and high). Ducklings were allocated to a 2 × 2 factorial arrangement with 2 kinds of vitamin premixes and without or with 25-OH-D at 0.069 mg/kg in LND diets. The high premix had higher levels of all vitamins except biotin than the regular premix. The results demonstrated that high vitamin diets exhibited more significant effects than regular vitamin diets on inhibiting bone turnover and increasing minerals deposition. Tibial mineral content, microarchitecture, and strength of birds under the regular vitamin regimen were increased by 25-OH-D supplementation; However, these positive effects were not observed in ducks under the high vitamin regimen. To conclude, 25-OH-D supplementation improves tibial mass by suppressing osteoclast-mediated bone resorption in meat ducks, and this positive impact only was observed in regular but not high vitamin regimen when birds fed an LND diet.
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http://dx.doi.org/10.1016/j.aninu.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750870PMC
December 2020

Performance-enhanced indoor MIMO-OFDM visible light communications using individual/joint CAZAC precoding techniques.

Appl Opt 2020 Dec;59(34):10746-10753

In this paper, efficient individual and joint constant amplitude zero auto-correlation (CAZAC) precoding schemes are proposed to improve the performance of an indoor multiple-input multiple-output-orthogonal frequency division multiplexing (MIMO-OFDM)-based visible light communication (VLC) system. By considering the proposed precoding scheme, a 3×3 MIMO-OFDM VLC system with symmetrical and asymmetrical structure is set up, whose peak-to-average-power ratio (PAPR) of transmitted signal, signal-to-noise ratio (SNR), and bit error rate performance are investigated. It is shown that both individual and joint CAZAC precoding schemes can reduce the PAPR of the transmitted signal and make the SNR uniform over data subcarriers, resulting in significant performance improvement compared to the system without precoding. It is demonstrated that there are similar performance improvements for the MIMO-OFDM VLC system using the individual CAZAC precoding and joint CAZAC precoding in a symmetric scenario. At the expense of higher implementation complexity, the joint CAZAC precoding has more performance benefits than the individual CAZAC precoding for the VLC system with asymmetrical MIMO.
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http://dx.doi.org/10.1364/AO.409761DOI Listing
December 2020

Effect of benzoic acid on production performance, egg quality, intestinal morphology, and cecal microbial community of laying hens.

Poult Sci 2021 Jan 7;100(1):196-205. Epub 2020 Oct 7.

Animal Nutrition Institute, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

This study was conducted to determine the effects of supplemental dietary benzoic acid on production performance, egg quality, intestinal morphology, and intestinal microbiota of laying hens. A total of seven hundred twenty 45-wk-old Lohman pink-shell laying hens were randomly allocated to 3 dietary treatments: control (CON), diet supplemented with 1,000 mg/kg benzoic acid (BA1), and 2,000 mg/kg benzoic acid (BA2). Each treatment included 10 replicates of 24 hens; laying hens were monitored for 16 wk. Overall, the results indicate that benzoic acid supplementation had no effect on laying rate, feed intake, feed conversion ratio, and breaking rate; however, a decrease in egg weight (P < 0.01) was observed in the BA2 group. Albumen height and Haugh unit (HU) were also linearly increased in the BA1 and BA2 groups (linear effect, P < 0.05). An increase in duodenum villus height (V) (quadratic effect, P = 0.041) and crypt depth (C) (linear effect, P = 0.012) was observed in the BA2 group, whereas an increased jejunum C and decreased V/C (quadratic effect, P < 0.05) in the BA1 group. Moreover, an increase in ileum V and C (quadratic effect, P < 0.05) was observed in the BA1 group. Microbial richness and diversity were reduced in the BA2 group (P < 0.01). An increase in the abundance of Clostridia (class), Clostridiales (order), Ruminococcaceae (family), and Lachnospiraceae (family) was noted in the BA1 group, whereas an enrichment of Bacteroides caecicola (species) was observed in the BA2 group. The HU positively correlated with genus Sphaerochaeta and Enorma (r = 0.56, 0.56; P < 0.05) but negatively correlated with Romboutsia, Subdoligranulum, Helicobacter, and Mucispirillum (r = -0.58, -0.49, -0.48; -0.70; P < 0.05). In conclusion, dietary supplementation with benzoic acid had no effect on production performance, but it significantly improved egg quality. In addition, 1,000 mg/kg benzoic acid positively modulated intestinal health by improving intestinal morphology and enriching microbial composition.
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http://dx.doi.org/10.1016/j.psj.2020.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772661PMC
January 2021

FENDRR Sponges miR-424-5p to Inhibit Cell Proliferation, Migration and Invasion in Colorectal Cancer.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980102

Department of Colorectal and Anal Surgery, Lishui Municipal Central Hospital, Zhejiang Province, China.

Objective: LncRNAs are non-coding RNAs exerting vital roles in the occurrence and development of various cancer types. This study tended to describe the expression pattern of FENDRR in colorectal cancer (CRC), and further investigate the role of FENDRR in CRC cell biological behaviors.

Methods: Gene expression profile of colon cancer was accessed from the TCGA database, and then processed for differential analysis for identification of differentially expressed lncRNAs and miRNAs. Some experiments like qRT-PCR, MTT, colony formation assay, wound healing assay and Transwell assay were performed to assess the effect of FENDRR on cell biological behaviors. Dual-luciferase reporter assay was conducted to further validate the targeting relationship between FENDRR and miR-424-5p, and rescue experiments were carried out for determining the mechanism of FENDRR/miR-424-5p underlying the proliferation, migration and invasion of CRC cells.

Results: Bioinformatics analysis suggested that FENDRR was significantly down-regulated in CRC tissue, and low FENDRR was intimately correlated to poor prognosis. FENDRR overexpression could greatly inhibit cell proliferation, migration and invasion. Besides, there was a negative correlation between FENDRR and miR-424-5p. Dual-luciferase reporter assay indicated that miR-424-5p was a direct target of FENDRR. Rescue experiments discovered that FENDRR exerted its role in cell proliferation, migration and invasion in CRC via targeting miR-424-5p.

Conclusion: FENDRR is poorly expressed in CRC tissue and cells, and low FENDRR is responsible for the inhibition of cell proliferation, migration and invasion of CRC by means of targeting miR-424-5p.
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http://dx.doi.org/10.1177/1533033820980102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768317PMC
December 2020

Characterization of the Intestinal Microbiota of Broiler Breeders With Different Egg Laying Rate.

Front Vet Sci 2020 24;7:599337. Epub 2020 Nov 24.

College of Agriculture and Forestry, Pu'er University, Pu'er City, China.

The gastrointestinal microbiota plays a pivotal role in maintaining animal health, immunity and reproductive performances. However, literature about the relationship between microbiota and reproductive performance is limited. The aim of the present study was to determine differences in the intestinal microbiota of broiler breeders with different egg laying rate. A total of 200 AA+ parent broiler breeders (41-week-old) were separated into two groups according to their different egg laying rate [average egg laying rate group (AR: 78.57 ± 0.20%) and high egg laying rate group (HR: 90.79 ± 0.43%). Feed conversion ratio (FCR), ovary cell apoptosis rate (ApoCR) and relative abdominal fat weight were lower ( = 0.01), while the hatchability rate of qualified egg was higher ( = 0.04) in HR group than that in AR group. abundance were lower ( = 0.012) in ileum of HR birds. (genus) in ileum was negatively related to the feed efficiency ( = -0.58, < 0.05), (phylum) and (genus) abundances in cecum were positively related to the egg laying rate (ELR) ( = 0.35 and 0.48, < 0.05), feed efficiency ( = 0.42 and 0.43, < 0.05), while (phylum) and (genus) abundances in cecum were negatively related to the ELR ( = -0.43 and -0.70, < 0.05), feed efficiency ( = 0.54 and 0.48, < 0.05), and positively related to ApoCR ( = 0.46 and 0.47, < 0.05). Our results suggested that microbiota, such as (phylum) and (genus) have positive relationship, while (phylum) (genus) abundances exert negative relationship with broiler breeders' reproductive performances.
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http://dx.doi.org/10.3389/fvets.2020.599337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732610PMC
November 2020

Health-Related Quality of Life in Transplant-Ineligible Patients With Newly Diagnosed Multiple Myeloma: Findings From the Phase III MAIA Trial.

J Clin Oncol 2021 Jan 16;39(3):227-237. Epub 2020 Dec 16.

Department of Oncology, Hematology, BMT with Department of Pneumology, University Medical Center Hamburg, Hamburg, Germany.

Purpose: To evaluate the effects of daratumumab, lenalidomide, and dexamethasone (D-Rd) versus lenalidomide and dexamethasone (Rd) on patient-reported outcomes (PROs) in the phase III MAIA study.

Patients And Methods: PROs were assessed on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item and the EuroQol 5-dimensional descriptive system at baseline and every 3 months during treatment. By mixed-effects model, changes from baseline are presented as least squares means with 95% CIs.

Results: A total of 737 transplant-ineligible (TIE) patients with newly diagnosed multiple myeloma were randomly assigned to D-Rd (n = 368) or Rd (n = 369). Compliance with PRO assessments was high at baseline (> 90%) through month 12 (> 78%) for both groups. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item global health status scores improved from baseline in both groups and were consistently greater with D-Rd at all time points. A global health status benefit was achieved with D-Rd, regardless of age (< 75 and ≥ 75 years), baseline Eastern Cooperative Oncology Group (ECOG) performance status score, or depth of response. D-Rd treatment resulted in significantly greater reduction in pain scores as early as cycle 3 ( = .0007 Rd); the magnitude of change was sustained through cycle 12. Reductions in pain with D-Rd were clinically meaningful in patients regardless of age, ECOG status, or depth of response. Similarly, PRO improvements were observed with D-Rd and Rd on the EuroQol 5-dimensional descriptive system visual analog scale score.

Conclusion: D-Rd compared with Rd was associated with faster and sustained clinically meaningful improvements in PROs, including pain, in transplant-ineligible patients with newly diagnosed multiple myeloma regardless of age, baseline ECOG status, or depth of treatment response.
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http://dx.doi.org/10.1200/JCO.20.01370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078427PMC
January 2021

Two new nucleoside derivatives isolated from the marine-derived and their intramolecular transesterification.

Nat Prod Res 2020 Dec 15:1-8. Epub 2020 Dec 15.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Two new nucleoside derivatives, kipukasins M () and N (), along with one known analogue, kipukasin J (), were obtained from the marine-derived fungus , which was isolated from the mud collected in the South China Sea. The structures of compounds and were elucidated by extensive spectroscopic analysis, mainly including 1D & 2D NMR and HRESIMS data, and the absolute configuration of was further confirmed by single-crystal X-ray diffraction analysis. Interestingly, intramolecular transesterification occurs in compounds and , which exist as a pair of inseparable regioisomers. All isolated compounds were tested for the cytotoxic and antimicrobial activities.
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http://dx.doi.org/10.1080/14786419.2020.1858409DOI Listing
December 2020

Hypoxylonoids A-G: Isopimarane diterpene glycosides from Xylaria hypoxylon.

Phytochemistry 2021 Feb 11;182:112613. Epub 2020 Dec 11.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China. Electronic address:

Seven undescribed isopimarane diterpene glycosides hypoxylonoids A-G, along with five known analogues were obtained from the fungus Xylaria hypoxylon. The structures and absolute configurations of hypoxylonoids A-G were confirmed by extensive spectroscopic and single-crystal X-ray diffraction analyses. Among these compounds, the γ-lactone moiety formed between C-19 and C-6 of hypoxylonoid A; the 1,2-methyl shift of Me-18 of hypoxylonoids B and E; and the decarboxylation of C-19 of hypoxylonoid E, make them outstanding from the isopimarane family. Single crystal X-ray diffraction analyses of hypoxylonoids A, C, F, and 15-hydroxy-16-α-D-mannopyranosyloxyisopimar-7-en-19-oic acid was performed to determine their absolute structural configuration.
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http://dx.doi.org/10.1016/j.phytochem.2020.112613DOI Listing
February 2021