Publications by authors named "Jianjun Yang"

416 Publications

A Novel Modification of Copper (II) Phthalocyanine Particles towards Electrophoretic Displays.

Micromachines (Basel) 2022 May 31;13(6). Epub 2022 May 31.

South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China.

Electrophoretic display (EPD) is a popular display technology in recent years. The core of the EPD is electrophoretic particles, and its Zeta potential has an important impact on EPDs. In this work, a method using pyrrolidine mono ionic liquid was proposed to improve the Zeta potential of electrophoretic particles: Copper (II) phthalocyanine pigment was modified with mono ionic liquid 1-Butyl-1-methylpyrrolidinium bromide. The characterization results show that the mono ionic liquid had been successfully coated on pigment particles. At the same time, the dispersion and stability of particles were improved. The modified Copper (II) phthalocyanine pigment could be stably dispersed in tetrachloroethylene for more than 20 days. The Zeta potential increased from 32.42 mV to 49.91 mV, increasing by 53.95%. Finally, the prepared blue electrophoretic particles were compounded with white titanium dioxide to prepare blue and white dual-color electrophoretic dispersion, and then an EPD cell was designed to test its performance. The results show that the prepared electrophoretic dispersion can realize reversible reciprocating motion. Therefore, because of the unique structure and properties of pyrrolidine mono ionic liquids, the blue nanoparticles prepared with pyrrolidine ionic liquids as charge control agents in this study can be used as excellent candidate materials for EPD.
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http://dx.doi.org/10.3390/mi13060880DOI Listing
May 2022

Current Understanding of Long-Term Cognitive Impairment After Sepsis.

Front Immunol 2022 6;13:855006. Epub 2022 May 6.

Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a dysregulated host response to infection. Although the incidence and mortality of sepsis decrease significantly due to timely implementation of anti-infective and support therapies, accumulating evidence suggests that a great proportion of survivors suffer from long-term cognitive impairment after hospital discharge, leading to decreased life quality and substantial caregiving burdens for family members. Several mechanisms have been proposed for long-term cognitive impairment after sepsis, which are not mutually exclusive, including blood-brain barrier disruption, neuroinflammation, neurotransmitter dysfunction, and neuronal loss. Targeting these critical processes might be effective in preventing and treating long-term cognitive impairment. However, future in-depth studies are required to facilitate preventive and/or treatment strategies for long-term cognitive impairment after sepsis.
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http://dx.doi.org/10.3389/fimmu.2022.855006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120941PMC
May 2022

Silencing of B7H4 Represses the Development of Oral Squamous Cell Carcinoma Through Promotion of M1 Macrophage Polarization.

J Oral Maxillofac Surg 2022 Apr 15. Epub 2022 Apr 15.

Professor, Department of Oral and Maxillofacial Surgery, Affiliated Hospital, Qingdao University, Qingdao City, Shandong Province, China. Electronic address:

Purpose: Tumor-associated macrophages can support oral squamous cell carcinoma (OSCC) progression, and overexpression of the immunomodulator B7H4 correlates with poor prognosis of OSCC patients. We performed this study to assess the effect of B7H4 silencing on macrophage polarization and explore the potential mechanism of B7H4 during OSCC progression.

Methods: Short hairpin RNA targeting B7H4 was used to knock down B7H4. The predictor variable was B7H4 expression level, and the outcome variables were SCC9 cell growth and metastasis, M1/M2 macrophage ratio, and anti-programmed death-1 (PD-1)/STAT3 pathway-related protein levels. These were measured through real-time qPCR, Western blot analysis, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT), 5-ethynyl-2'-deoxyuridine assay, and transwell assay. In addition, a tumor xenograft mouse model was used to examine the effect of B7H4 silencing (+/- Colivelin, an activator of STAT3) on tumor growth and macrophage polarization.

Results: The expression of B7H4 in OSCC cell lines was more than 2-fold compared with that in human normal oral keratinocytes via real-time qPCR and Western blot analysis. Knockdown of B7H4 repressed the proliferation, migration, and invasion of SCC9 cells, which were detected by 5-ethynyl-2'-deoxyuridine and transwell assay, as well as reduced PD-1/STAT3 pathway-related protein levels, promoted M1 macrophage polarization, and inhibited M2 polarization. In vivo research demonstrated that B7H4 silencing also inhibited the growth of tumor xenograft and increased the M1/M2 ratio in an OSCC mouse model. Colivelin reversed the inhibitory effects of B7H4 knockdown on OSCC progression and reversed macrophage polarization both in vitro and in vivo.

Conclusions: B7H4 is upregulated during OSCC progression. Its downregulation may promote M1 macrophage polarization and inhibit M2 macrophage polarization via deactivating the PD-1/STAT3 pathway, thus restraining OSCC development.
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http://dx.doi.org/10.1016/j.joms.2022.03.019DOI Listing
April 2022

Quality of Recovery After General Anesthesia with Remimazolam in Patients' Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol.

Drug Des Devel Ther 2022 27;16:1199-1209. Epub 2022 Apr 27.

Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Background: Remimazolam is a new medication with sedative and hypnotic effects. It has been demonstrated non-inferior to propofol in general anesthesia with regard to efficacy and safety. However, whether general anesthesia with remimazolam is better than propofol in terms of patients' recovery quality remains unknown.

Patients And Methods: Patients enrolled in this study were randomized to remimazolam or propofol group. In remimazolam group, general anesthesia was induced with remimazolam and sufentanil and maintained with remimazolam and remifentanil. In propofol group, general anesthesia was induced with propofol and sufentanil and maintained with propofol and remifentanil. Neuromuscular blocking agent cisatracurium was also injected during anesthesia. Sedation level was monitored by bispectral index (BIS). Our primary outcome was the quality of patients' postoperative recovery, using the Quality of Recovery-15 (QoR-15) scale. Secondary outcomes included SpO, HR, MBP and frequency of application of vasoactive drugs during anesthesia, as well as incidences of adverse events in the post anesthesia care unit (PACU).

Results: The global scores of QoR-15 scale were lower in remimazolam group at postoperative day 1 and day 3 compared to propofol group, but differences between the two groups only had clinical significance at postoperative day 1. Among the five dimensions of QoR-15 scale, scores for physical comfort and emotional state were lower in remimazolam group than propofol group. MBP and HR were higher in remimazolam group than propofol group after anesthesia induction. SpO was similar in the two groups. The frequency of application of vasoactive drugs during anesthesia was higher in propofol group than remimazolam group. There was no statistical difference in the incidences of adverse events between the two groups.

Conclusion: General anesthesia with remimazolam can provide more stable hemodynamics but also cause temporary reduction in the quality of recovery in patients undergoing urologic surgery, compared to propofol.
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http://dx.doi.org/10.2147/DDDT.S359496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058002PMC
May 2022

Vivid Structural Color Macropatterns Created by Flexible Nanopainting of Ultrafast Lasers.

ACS Appl Mater Interfaces 2022 May 2;14(18):21758-21767. Epub 2022 May 2.

GPL Photonics Laboratory, Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences (CAS), Changchun, Jilin 130033, People's Republic of China.

Structural colors based on the macro- or nanostructure formation are ubiquitous in nature, having great prospects in many fields as a result of their environmentally friendly and long-term stable characteristics compared to pigments or dyes. However, the current fabrication techniques still face challenges for the generation of high-quality structural color patterns, especially at the macroscale, in an efficient way. Here, we demonstrate a method that exploits a flexible scanning process of generating macropatterns to convert the contour profiles into well-defined sub-micrometer grating structures with unprecedented vivid structural colors, at high speed and low cost on the graphene oxide film. The nature of dynamic beam shaping of the laser line spot allows us to flexibly construct the complex patterns at high speed, in sharp contrast to the traditional point-by-point laser processing. Moreover, the multicolor display of the patterns can be carried out by simply modulating the laser polarization to change the orientation of the sub-micrometer structures, and this nanopainting strategy is further explored to flexibly design the composite image for potential anti-counterfeiting applications.
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http://dx.doi.org/10.1021/acsami.2c04542DOI Listing
May 2022

Synergistic effects of Cd-loving Bacillus sp. N3 and iron oxides on immobilizing Cd and reducing wheat uptake of Cd.

Environ Pollut 2022 Jul 14;305:119303. Epub 2022 Apr 14.

Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

Iron oxides and microorganisms are important soil components that profoundly affect the transformation and bioavailability of heavy metals in soils. Here, batch and pot experiments were conducted to investigate the immobilization mechanisms of Cd by Cd-loving Bacillus sp. N3 and ferrihydrite (Fh) as well as their impacts on Cd uptake by wheat and bacterial community composition in wheat rhizospheric soil. The results showed that the combination of strain N3 with Fh could immobilize more Cd compared to strain N3 and Fh, respectively. Furthermore, strain N3 facilitated Cd retention on Fh, which synergistically reduced the concentration of DTPA extracted Cd in the soil and decreased Cd content (57.1%) in wheat grains. Moreover, inoculation with strain N3 increased the complexity of the co-occurrence network of the bacterial community in rhizospheric soil, and the abundance of beneficial bacteria with multipel functions including heavy metal immobilization, dissimilatory iron reduction, and plant growth promotion. Overall, this study demonstrated the enrichment of strain N3 and iron oxides, together with increased soil pH, synergistically immobilized soil Cd, which strongly suggested inoculation with Cd-loving strains could be a promising approach to immobilize Cd and reduce wheat uptake of Cd, particular for soils rich in iron oxides.
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http://dx.doi.org/10.1016/j.envpol.2022.119303DOI Listing
July 2022

Preparation of mussel-inspired silver/polydopamine antibacterial biofilms on Ti-6Al-4V for dental applications.

RSC Adv 2022 Feb 25;12(11):6641-6648. Epub 2022 Feb 25.

The Affiliated Hospital of Qingdao University Qingdao 266003 China

The properties of osseointegration and antibacterial ability is vital import for dental materials. Herein, we designed the multilayer TC4-Ag-polydopamine coatings, to provide TC4 with slow-release antibacterial properties whilst maintaining cytocompatibility. In brief, thickness of Ag inner layer can be easily controlled by magnetron sputtering technology. The resulting top polydopamine layer protected the Ag well from corrosion and gave a sustained release of Ag up to one month. In addition, the prepared TC4-Ag-polydopamine samples with Ag thickness of 20 and 30 nm, showed high hydrophilic performance with the contact-angle less than 20°, low cytotoxicity and good cytocompatibility. Expectedly, it could become a prospective candidate for future slow-release antibacterial dental materials.
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http://dx.doi.org/10.1039/d1ra06634jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982268PMC
February 2022

Accurate 3D Reconstruction of White Matter Hyperintensities Based on Attention-Unet.

Comput Math Methods Med 2022 23;2022:3812509. Epub 2022 Mar 23.

Department of Neurology, Shandong Provincial Third Hospital, Shandong University, Jinan, 250031 Shandong, China.

White matter hyperintensities (WMH), also known as white matter osteoporosis, have been clinically proven to be associated with cognitive decline, the risk of cerebral infarction, and dementia. The existing computer automatic measurement technology for the segmentation of patients' WMH does not have a good visualization and quantitative analysis. In this work, the author proposed a new WMH quantitative analysis and 3D reconstruction method for 3D reconstruction of high signal in white matter. At first, the author using ResUnet achieves the high signal segmentation of white matter and adds the attention mechanism into ResUnet to achieve more accurate segmentation. Afterwards, this paper used surface rendering to reconstruct the accurate segmentation results in 3D. Data experiments are conducted on the dataset collected from Shandong Province Third Hospital. After training, the Attention-Unet proposed in this paper is superior to other segmentation models in the segmentation of high signal in white matter and Dice coefficient and MPA reached 92.52% and 92.43%, respectively, thus achieving accurate 3D reconstruction and providing a new idea for quantitative analysis and 3D reconstruction of WMH.
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http://dx.doi.org/10.1155/2022/3812509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967522PMC
April 2022

Identifying a New Social Intervention Model of Panic Buying Under Sudden Epidemic.

Front Public Health 2022 11;10:842904. Epub 2022 Mar 11.

School of Tourism and Urban-Rural Planning, Zhejiang Gongshang University, Hangzhou, China.

COVID-19 that broke out at the end of 2019 continues to spread globally, with frequent occurrence of variant disease strains, thus epidemic prevention and control become a kind of routine job. At present, due to the prevention and control measures such as maintaining social distance and community blockades, there is a boom in material purchases in many places, which not only seriously endangers social order and public environmental safety, but also easily leads to the interruption of the supply chain and the shortage of social materials. This article aims to study the intervention methods to curb the spread and spread of panic buying behavior. Firstly, through crawler technology and LDA (Latent Dirichlet Allocation) topic model, this article analyzes the intervention measures taken by various social forces in China to curb the spread of panic buying, and summarizes the multi-channel intervention measures including online and offline forms. Secondly, through the multi-Agent Monte Carlo method, the targeted intervention mechanism is supplemented in each propagation link of the panic buying propagation model, and a new social intervention model of panic buying under sudden epidemic is constructed. Then, through MATLAB modeling and simulation, the main factors affecting panic buying intervention are discussed. The simulation results show that: (1) The single plan with the best intervention effect is the supply monitoring. While the official response can play an immediate inhibitory effect, but it is affected by credibility and timeliness. The intervention effect of psychological counseling is limited, and it generally needs to be used in combination with other measures. (2) The combination strategy with the best intervention effect is "supply monitoring + official response + psychological counseling," and the worst is "information review and guidance + psychological counseling." Supply monitoring is a key measure to curb panic buying. At the same time, "information review and guidance" will have a certain counter-effect in the combined strategy. Finally, the effectiveness and universality of the proposed model are verified by examples of China and Britain.
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http://dx.doi.org/10.3389/fpubh.2022.842904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963413PMC
April 2022

Diagnosis of Liver Cirrhosis and Liver Fibrosis by Artificial Intelligence Algorithm-Based Multislice Spiral Computed Tomography.

Comput Math Methods Med 2022 15;2022:1217003. Epub 2022 Mar 15.

Department of Chronic Disease Control, Yulin City Center for Disease Control and Prevention, Yulin, 719000 Shaanxi, China.

This research was aimed at investigating the artificial intelligence (AI) segmentation algorithm-based multislice spiral computed tomography (MSCT) in the diagnosis of liver cirrhosis and liver fibrosis. Besides, it was aimed at providing new methods for the diagnosis of liver cirrhosis and liver fibrosis. All patients were divided into the control group, mild liver fibrosis group, and significant liver fibrosis group. A total of 112 patients were included, with 40 cases in the mild liver fibrosis group, 48 cases in the significant liver fibrosis group, and 24 cases who underwent computed tomography (CT) examination in the control group. In the research, deconvolution algorithm of AI segmentation algorithm was adopted to process the images. The average hepatic arterial fraction (HAF) values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 17.59 ± 10.03%, 18.23 ± 5.57%, and 20.98 ± 6.63%, respectively. The average MTT values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 12.69 ± 1.78S, 12.53 ± 2.05S, and 12.04 ± 1.57S, respectively. The average blood flow (BF) values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 105.68 ± 15.57 mL 100 g·min, 116.07 ± 16.5 mL·100 g·min, and 110.39 ± 16.32 mL·100 g·min, respectively. Besides, the average blood volume (BV) values of patients in the control group, mild liver fibrosis group, and significant liver fibrosis group were 15.69 ± 4.35 mL·log, 16.97 ± 2.68 mL·log, and 16.11 ± 4.87 mL·100 g, respectively. According to statistics, the differences among the average HAF, MTT, BF, and BV values showed no statistical meaning. AI segmentation algorithm-based MSCT imaging could promote the diagnosis of liver cirrhosis and liver fibrosis effectively and offer new methods to clinical diagnosis of liver cirrhosis and liver fibrosis.
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http://dx.doi.org/10.1155/2022/1217003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941514PMC
April 2022

Significance of Species for the Phytoavailability and Toxicity of Arsenic-A Review.

Biology (Basel) 2022 Mar 18;11(3). Epub 2022 Mar 18.

Department of Life Sciences, Institute for Plant Biology, Technical University of Braunschweig, 38106 Braunschweig, Germany.

The distribution of arsenic continues due to natural and anthropogenic activities, with varying degrees of impact on plants, animals, and the entire ecosystem. Interactions between iron (Fe) oxides, bacteria, and arsenic are significantly linked to changes in the mobility, toxicity, and availability of arsenic species in aquatic and terrestrial habitats. As a result of these changes, toxic As species become available, posing a range of threats to the entire ecosystem. This review elaborates on arsenic toxicity, the mechanisms of its bioavailability, and selected remediation strategies. The article further describes how the detoxification and methylation mechanisms used by species could serve as a potential tool for decreasing phytoavailable As and lessening its contamination in the environment. If taken into account, this approach will provide a globally sustainable and cost-effective strategy for As remediation and more information to the literature on the unique role of this bacterial species in As remediation as opposed to conventional perception of its role as a mobiliser of As.
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http://dx.doi.org/10.3390/biology11030472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944983PMC
March 2022

Modeling Rumor Diffusion Process With the Consideration of Individual Heterogeneity: Take the Imported Food Safety Issue as an Example During the COVID-19 Pandemic.

Front Public Health 2022 7;10:781691. Epub 2022 Mar 7.

School of Tourism and Urban-Rural Planning, Zhejiang Gongshang University, Hangzhou, China.

At present, rumors appear frequently in social platforms. The rumor diffusion will cause a great impact on the network order and the stability of the society. So it's necessary to study the diffusion process and develop the rumor control strategies. This article integrates three heterogeneous factors into the SEIR model and designs an individual state transition mode at first. Secondly, based on the influencing factors such as the trust degree among individuals, an individual information interaction mode is constructed. Finally, an improved SEIR model named SEIR-OM model is established, and the diffusion process of rumors are simulated and analyzed. The results show that: (1) when the average value of the interest correlation is greater, the information content deviation is lower, but the rumor diffusion range will be wider. (2) The increase of the average network degree intensifies influence of rumors, but its impact on the diffusion has a peak. (3) Adopting strategies in advance can effectively reduce the influence of rumors. In addition, the government should enforce rumor-refuting strategies right after the event. Also, the number of rumor-refuting individuals must be paid attention to. Finally, the article verifies the rationality and effectiveness of the SEIR-OM model through the real case.
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http://dx.doi.org/10.3389/fpubh.2022.781691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940522PMC
March 2022

BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model.

BMC Psychiatry 2022 03 15;22(1):182. Epub 2022 Mar 15.

Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Background: Preclinical studies have indicated that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its effects and molecular mechanisms remain unclear. In this work, we examined the involvement of brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) and Narp in the antidepressant-like actions of (2R,6R)-HNK in a chronic restraint stress (CRS) mouse model.

Methods: C57BL/6 male mice were subjected to CRS for 8 h per day for 14 consecutive days. Open field, forced swimming, novelty suppressed feeding, and tail suspension tests were performed after administering (2R,6R)-HNK (10 mg/kg), a combination of (2R,6R)-HNK and NBQX (an alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist; 10 mg/kg), or a combination of (2R,6R)-HNK and ANA-12 (a TrkB receptor antagonist; 0.5 mg/kg). The mRNA levels of Bdnf and Narp in the hippocampus were determined by quantitative reverse transcription-PCR (qRT-PCR). Western blotting was used to determine the hippocampal protein levels of GluA1, GluA2, BDNF, Narp, PSD95, and synaptophysin, as well as the p-TrkB/TrkB protein ratio.

Results: (2R,6R)-HNK had rapid antidepressant-like effects in CRS mice. Furthermore, (2R,6R)-HNK significantly ameliorated CRS-induced downregulation of GluA1, GluA2, BDNF, Narp, PSD95, and the p-TrkB/TrkB protein ratio in the hippocampus. The effects of (2R,6R)-HNK were blocked by combinations with NBQX or ANA-12.

Conclusion: BDNF-TrkB signaling-mediated upregulation of Narp in the hippocampus may play a key role in the antidepressant-like effect of (2R,6R)-HNK in the CRS model of depression.
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http://dx.doi.org/10.1186/s12888-022-03838-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922900PMC
March 2022

Iron plaque formation, characteristics, and its role as a barrier and/or facilitator to heavy metal uptake in hydrophyte rice (Oryza sativa L.).

Environ Geochem Health 2022 Mar 15. Epub 2022 Mar 15.

Department of Life Sciences, Institute for Plant Biology, Technical University of Braunschweig, 38106, Braunschweig, Germany.

The persistent bioavailability of toxic metal(oids) (TM) is undeniably the leading source of serious environmental problems. Through the transfer of these contaminants into food networks, sediments and the aquatic environmental pollution by TM serve as key routes for potential risks to soil and human health. The formation of iron oxyhydroxide plaque (IP) on the root surface of hydrophytes, particularly rice, has been linked to the impact of various abiotic and biotic factors. Radial oxygen loss has been identified as a key driver for the oxidation of rhizosphere ferrous iron (Fe) and its subsequent precipitation as low-to-high crystalline and/or amorphous Fe minerals on root surfaces as IP. Considering that each plant species has its unique capability of creating an oxidised rhizosphere under anaerobic conditions, the abundance of rhizosphere Fe, functional groups from organic matter decomposition and variations in binding capacities of Fe oxides, thus, impacting the mobility and interaction of several contaminants as well as toxic/non-toxic metals on the specific surface areas of the IP. More insight from wet extraction and advanced synchrotron-based analytical techniques has provided further evidence on how IP formation could significantly affect the fate of plant physiology and biomass production, particularly in contaminated settings. Collectively, this information sets the stage for the possible implementation of IP and related analytical protocols as a strategic framework for the management of rice and other hydrophytes, particularly in contaminated sceneries. Other confounding variables involved in IP formation, as well as operational issues related to some advanced analytical processes, should be considered.
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http://dx.doi.org/10.1007/s10653-022-01246-4DOI Listing
March 2022

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells.

Cell Death Discov 2022 Mar 12;8(1):112. Epub 2022 Mar 12.

Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Histone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily, participates in various cardiovascular diseases. Recent evidence showed that pyroptosis was a form of inflammatory programmed cell death and is critical for atherosclerosis (AS). However, little is known about the effect of HDAC11 on endothelial cell pyroptosis in AS. Thus, this study aims to investigate the role of HDAC11 in vascular endothelial cell pyroptosis and its molecular mechanism. Firstly, we found that HDAC11 expression was up-regulated and pyroptosis occurred in the aorta of ApoE mice fed with a high-fat diet (HFD) for 8 or 12 weeks. Then, in vitro study found the treatment of human umbilical vein endothelial cells (HUVECs) with tumor necrosis factor-α (TNF-α) resulted in pyroptosis, as evidenced by activation of caspase-1 and caspase-3 activation, cleavage of downstream gasdermin D (GSDMD) and gasdermin E (GSDME/DFNA5), the release of pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and IL-18, as well as elevation of LDH activity and increase of propidium iodide (PI)-positive cells. Besides, TNF-α increased HDAC11 expression and induced pyroptosis via TNFR1 in HUVECs. HDAC11 knockdown mitigated pyroptosis by suppressing both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways in TNF-α-induced HUVECs. Moreover, GSDME knockdown by siRNA significantly decreased pyroptosis and inflammatory response, while treatment with disulfiram or necrosulfonamide (NSA) further augmented the inhibitory effects of GSDME siRNA on pyroptosis and inflammatory response. Further studies found HDAC11 formed a complex with ERG and decreased the acetylation levels of ERG. More importantly, ERG knockdown augmented vascular endothelial cell pyroptosis in TNF-α-induced HUVECs. Taken together, our study suggests that HDAC11 might promote both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways leading to pyroptosis via regulation of ERG acetylation in HUVECs. Modulation of HDAC11 may serve as a potential target for therapeutic strategies of AS.
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http://dx.doi.org/10.1038/s41420-022-00906-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918356PMC
March 2022

Manipulation of Subwavelength Periodic Structures Formation on 4H-SiC Surface with Three Temporally Delayed Femtosecond Laser Irradiations.

Nanomaterials (Basel) 2022 Feb 26;12(5). Epub 2022 Feb 26.

School of Science, Xi'an Shiyou University, Xi'an 710065, China.

Controlling laser-induced periodic surface structures on semiconductor materials is of significant importance for micro/nanophotonics. We here demonstrate a new approach to form the unusual structures on 4H-SiC crystal surface under irradiation of three collinear temporally delayed femtosecond laser beams (800 nm wavelength, 50 fs duration, 1 kHz repetition), with orthogonal linear polarizations. Different types of surface structures, two-dimensional arrays of square islands (670 nm periodicity) and one-dimensional ripple structures (678 nm periodicity) are found to uniformly distribute over the laser-exposed areas, both of which are remarkably featured by the low spatial frequency. By altering the time delay among three laser beams, we can flexibly control the transition between the two surface structures. The experimental results are well explained by a physical model of the thermally correlated actions among three laser-material interaction processes. This investigation provides a simple, flexible, and controllable processing approach for the large-scale assembly of complex functional nanostructures on bulk semiconductor materials.
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http://dx.doi.org/10.3390/nano12050796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912547PMC
February 2022

Directly Printed Embedded Metal Mesh for Flexible Transparent Electrode via Liquid Substrate Electric-Field-Driven Jet.

Adv Sci (Weinh) 2022 May 1;9(14):e2105331. Epub 2022 Mar 1.

Shandong Engineering Research Center for Additive Manufacturing, Qingdao University of Technology, Qingdao, 266520, China.

Flexible transparent electrodes (FTEs) with embedded metal meshes play an indispensable role in many optoelectronic devices due to their excellent mechanical stability and environmental adaptability. However, low-cost, simple, efficient, and environmental friendly integrated manufacturing of high-performance embedded metal meshes remains a huge challenge. Here, a facile and novel fabrication method is proposed for FTEs with an embedded metal mesh via liquid substrateelectric-field-driven microscale 3D printing process. This direct printing strategy avoids tedious processes and offers low-cost and high-volume production, enabling the fabrication of high-resolution, high-aspect ratio embedded metal meshes without sacrificing transparency. The final manufactured FTEs with 80 mm × 80 mm embedded metal mesh offers excellent optoelectronic performance with a sheet resistance (R ) of 6 Ω sq and a transmittance (T) of 85.79%. The embedded metal structure still has excellent mechanical stability and good environmental suitability under different harsh working conditions. The practical feasibility of the FTEs is successfully demonstrated with a thermally driven 4D printing structure and a resistive transparent strain sensor. This method can be used to manufacture large areas with facile, high-efficiency, low-cost, and high-performance FTEs.
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http://dx.doi.org/10.1002/advs.202105331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108624PMC
May 2022

The effects of plastic film mulching and straw mulching on licorice root yield and soil organic carbon content in a dryland farming.

Sci Total Environ 2022 Jun 24;826:154113. Epub 2022 Feb 24.

State Key Laboratory of Grassland Agro-ecosystems, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China. Electronic address:

The increasing worldwide demand for traditional herbs has been met by growing cultivated herbs. It is undoubtedly very important to seek a reasonable cultivation mode for the yield, quality and long-term production stability of traditional herbs. In this study, licorice (Glycyrrhiza uralensis Fisch.) was investigated using a field experiment and a process-based model (Denitrification-Decomposition (DNDC) model) to study the effects of mulching methods on root yield and soil organic carbon (SOC) long-term changes. The field experiment contained four treatments: plat planting without mulching (CK), ridge-furrow maize straw mulching (SM), ridge-furrow plastic film mulching (RP), and plat planting with plastic film mulching (FP). Licorice root yield was significantly higher in the SM, RP, and FP than in the CK. SM, RP and FP treatments increased the accumulation of liquiritin and glycyrrhizin in licorice roots. The SM significantly increased SOC content, SOC stocks, SOC sequestration rate, dissolved organic carbon (DOC) content and microbial biomass carbon (MBC) compared to CK, but there was no significant difference in SOC and DOC among CK, RP and FP. The DNDC model was calibrated based on the field test data and showed that under the four CMIP6 SSPs scenarios, the predicted root yield of each treatment was increasing obviously. The production and stability of RP and FP were greater than CK and SM. The SOC under SM showed an increasing trend, whereas it continuously decreased under CK, RP, and FP in the future. The SOC of simulated RS treatment of straw incorporation plus a plastic film mulch was always at the highest value in all the treatments, and its root yield was slightly lower than that of RP and FP, the latter both were very close. Therefore, it is suggested that RS should be adopted to achieve sustained high yield while maintaining a high SOC level.
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http://dx.doi.org/10.1016/j.scitotenv.2022.154113DOI Listing
June 2022

Gut microbiota imbalance mediates intestinal barrier damage in high-altitude exposed mice.

FEBS J 2022 Feb 21. Epub 2022 Feb 21.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases & Digestive Diseases of Xijing Hospital, Fourth Military Medical University, Xi'an, China.

The environmental conditions in high-altitude areas can induce gastrointestinal disorders and changes in gut microbiota. The gut microbiota is closely related to a variety of gastrointestinal diseases, although the underlying pathogenic mechanisms are not well-identified. The present study aimed to investigate the regulatory effect of high altitude on intestinal dysfunction via gut microbiota disturbance. Forty C57BL/6J mice were divided into four groups: one plain control group (CON) and three high-altitude exposure groups (HAE) (altitude: 4000 m a.s.l.; oxygen content: 12.7%; 1-, 2- and 4-week exposure). Another set of 40 mice was divided into two CON and two HAE subgroups. Antibiotic cocktails were administered to one CON and HAE groups and autoclaved water was administered to the second CON and HAE groups for 4 weeks, respectively. In the fecal microbiota transplantation experiment, there were four transplantation groups, which received, respectively: phosphate-buffered saline for 2 weeks, feces from CON for 2 weeks, feces from HAE-4W for 2 weeks, and HAE-4W for 4 weeks. Hematoxylin and eosin staining, periodic acid-Schiff staining, a terminal deoxynucleotidyl transferase dUTP nick end labeling assay and a quantitative reverse transcriptase-polymerase chain reaction were applied to detect changes in intestinal cellular structure, morphology, apoptosis and intestinal inflammatory response. Fecal microbiota was analyzed using 16S rDNA amplicon sequencing. A high-altitude environment changed the ecological balance of gut microbiota in mice and caused damage to the intestinal structure and mucosal barrier. Interestingly, similar damage, which was inhibited by antibiotic cocktails at high altitude, was observed in mice transplanted with fecal microbiota from HAE. A high-altitude environment contributes to dyshomeostasis of gut microbiota, thereby impairing the intestinal mucosal barrier, eventually inducing and exacerbating intestinal damage.
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http://dx.doi.org/10.1111/febs.16409DOI Listing
February 2022

The rhizospheric transformation and bioavailability of mercury in pepper plants are influenced by selected Chinese soil types.

Environ Geochem Health 2022 Feb 6. Epub 2022 Feb 6.

School of Soil and Water Conservation, Beijing Forestry University, Beijing, 100083, China.

Understanding and prediction of mercury (Hg) phytoavailability in vegetable-soil systems is essential for controlling food chain contamination and safe vegetable production as Hg-contaminated soils pose a serious threat to human health. In this study, four typical Chinese soils (Heilongjiang, Chongqing, Yunnan, and Jilin) with varied physicochemical properties were spiked with HgCl to grow sweet pepper (Capsicum annuum L.) in a pot experiment under greenhouse condition. The chemical fractionation revealed a significant decrease in exchangeable Hg, while an increase in organically bound Hg in the rhizosphere soil (RS) compared to bulk soil (BS). This observation strongly highlights the vital role of organic matter on the rhizospheric Hg transformation irrespective of contamination levels and soil properties. Stepwise multiple linear regression (SMLR) analysis between Hg concentration in plants, Hg fractions in RS and BS, and soil properties showed that Hg in plant parts was significantly influenced by soil total Hg (THg) (R = 0.90), soil clay (R = 0.99), amorphous manganese oxides (amorphous Mn) (R = 0.97), amorphous iron oxides (amorphous Fe) (R = 0.70), and available Hg (R = 0.97) in BS. Nevertheless, in the case of RS, Hg accumulation in plants was affected by soil THg (R = 0.99), amorphous Mn (R = 0.97), amorphous Fe oxides (R = 0.66), soil pH, and organically bound Hg fraction (R = 0.96). Among all the evaluated soils (n = 04), metal (mercury) concentration in terms of plant uptake was reported highest in the Jilin soil. Based on SMLR analysis, the results suggested that the phytoavailability of Hg was mainly determined by THg and metal oxides regardless of the rhizospheric effect. These findings facilitate the estimation of Hg phytoavailability and ecological risk that may exist from Hg-contaminated areas where pepper is the dominant vegetable.
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http://dx.doi.org/10.1007/s10653-022-01209-9DOI Listing
February 2022

Molecular Insights into Roles of Dissolved Organic Matter in Cr(III) Immobilization by Coprecipitation with Fe(III) Probed by STXM-Ptychography and XANES Spectroscopy.

Environ Sci Technol 2022 02 2;56(4):2432-2442. Epub 2022 Feb 2.

Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

The coprecipitation of heavy metals (HMs) with Fe(III) in the presence of dissolved organic matter (DOM) is a crucial process to control the mobility of HMs in the environment, but its underlying immobilization mechanisms are unclear. In this study, Cr(III) immobilization by coprecipitation with Fe(III) in the presence of straw-derived DOMs under different Fe/C molar ratios, pHs, and ionic strengths was investigated using scanning transmission X-ray microscopy (STXM) and ptychography and X-ray absorption near-edge structure (XANES) spectroscopy. The results showed that Cr(III) retention was enhanced in the presence of DOM, a maximum of which was achieved at an Fe/C molar ratio of 0.5. The increase of pH and ionic strength could also promote Cr(III) immobilization. Cr K-edge XANES results indicated that Fe (oxy)hydroxide fractions, instead of organics, provided the predominant binding sites for Cr(III), which was directly confirmed by high spatial resolution STXM-ptychography analysis at the sub-micron- and nanoscales. Moreover, organics could indirectly facilitate Cr immobilization by improving the aggregation and deposition of coprecipitate particles through DOM bridging or electrostatic interactions. Additionally, C K-edge XANES analysis further indicated that the carboxylic groups of DOM were complexed with Fe (oxy)hydroxides, which probably contributed to DOM bridging. This study provides a new insight into Cr(III) immobilization mechanisms in its coprecipitation with Fe(III) and DOM, which could have important implications on the management of Cr(III)-enriched soils, particularly with crop straw returning.
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http://dx.doi.org/10.1021/acs.est.1c07528DOI Listing
February 2022

Coupled Sorption and Oxidation of Soil Dissolved Organic Matter on Manganese Oxides: Nano/Sub-nanoscale Distribution and Molecular Transformation.

Environ Sci Technol 2022 02 27;56(4):2783-2793. Epub 2022 Jan 27.

The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, School of Environment and Energy, South China University of Technology, Guangzhou, Guangdong 510006, People's Republic of China.

In soil environments, the sequestration and transformation of organic carbon are closely associated with soil minerals. Birnessite (MnO) is known to strongly interact with soil dissolved organic matter (DOM), but the microscopic distribution and molecular transformation of soil DOM on birnessite are still poorly understood. In this study, the coupled sorption and oxidation of soil DOM on birnessite were investigated at both the microscopic scale and the molecular level. Spherical aberration corrected scanning transmission electron microscopy (Cs-STEM) results revealed, at the nano- to sub-nanoscale, that DOM was located both on the surfaces and within the interflakes or pore spaces of birnessite, and DOM within the interflakes displayed a higher oxidation state than that on the surfaces. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) results suggested that a portion of phenolic compounds were preferentially sorbed and oxidized, resulting in the formation of compounds with higher oxygen contents and polymeric products. Our Cs-STEM and FT-ICR-MS results highlighted the significance of organo-mineral associations in the microscopic mineral structure for the reactivity of organic carbon and provided the molecular evidence for the transformation of soil DOM by birnessite, which contributed to the understanding of the dynamics of soil dissolved organic carbon.
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http://dx.doi.org/10.1021/acs.est.1c07520DOI Listing
February 2022

Semi-Infinite Structure Analysis with Bimodular Materials with Infinite Element.

Materials (Basel) 2022 Jan 15;15(2). Epub 2022 Jan 15.

School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK.

The modulus of elasticity of some materials changes under tensile and compressive states is simulated by constructing a typical material nonlinearity in a numerical analysis in this paper. The meshless Finite Block Method (FBM) has been developed to deal with 3D semi-infinite structures in the bimodular materials in this paper. The Lagrange polynomial interpolation is utilized to construct the meshless shape function with the mapping technique to transform the irregular finite domain or semi-infinite physical solids into a normalized domain. A shear modulus strategy is developed to present the nonlinear characteristics of bimodular material. In order to verify the efficiency and accuracy of FBM, the numerical results are compared with both analytical and numerical solutions provided by Finite Element Method (FEM) in four examples.
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http://dx.doi.org/10.3390/ma15020641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779496PMC
January 2022

A Novel Dye-Sensitized Solar Cell Structure Based on Metal Photoanode without FTO/ITO.

Micromachines (Basel) 2022 Jan 13;13(1). Epub 2022 Jan 13.

College of Electron and Information, University of Electronic Science and Technology of China, Zhongshan Institute, Zhongshan 528402, China.

Traditional dye-sensitized solar cells (DSSC) use FTO/ITO containing expensive rare elements as electrodes, which are difficult to meet the requirements of flexibility. A new type of flexible DSSC structure with all-metal electrodes without rare elements is proposed in this paper. Firstly, a light-receiving layer was prepared outside the metal photoanode with small holes to realize the continuous oxidation-reduction reaction in the electrolyte; Secondly, the processing technology of the porous titanium dioxide (TiO) film was analyzed. By testing the J-V characteristics, it was found that the performance is better when the heating rate is slow. Finally, the effects of different electrode material combinations were compared through experiments. Our results imply that in the case of all stainless-steel electrodes, the open-circuit voltage can reach 0.73 V, and in the case of a titanium photoanode, the photoelectric conversion efficiency can reach 3.86%.
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http://dx.doi.org/10.3390/mi13010122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780946PMC
January 2022

Inhibition of cadmium uptake by wheat with urease-producing bacteria combined with sheep manure under field conditions.

Chemosphere 2022 Apr 6;293:133534. Epub 2022 Jan 6.

Collaborative Innovation of Water Security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province, College of Life Sciences and Agricultural Engineering, Nanyang Normal University, Nanyang, 473061, PR China.

In heavy metal-contaminated farmland, microorganisms or organic fertilizers can be used to minimize heavy metal uptake by crops to ensure food safety. However, the mechanisms by which urease-producing and metal-immobilizing bacteria combined with manure inhibit Cd uptake in wheat (Triticum aestivum L.) remain unclear. Herein, the effects of Enterobacter bugandensis TJ6, sheep manure (SM), and TJ6 combined with SM on Cd uptake by wheat and the mechanisms involved were investigated under field conditions. The results showed that strain TJ6 increased the urease activity and the proportion of strains with a high Cd adsorption capacity in SM, thereby enhancing the Cd adsorption capacity of SM in solution. Strain TJ6 combined with SM improved the rhizosphere soil urease activity, NH/NO ratio, and pH, thus reducing the Cd content (75.9%) in wheat grain. In addition, TJ6+SM reduced the bacterial community diversity but shifted the structure of the bacterial community in rhizosphere soil. Interestingly, the relative abundances of urease-producing bacteria and metal-immobilizing bacteria (Enterobacter, Bacillus, Exiguobacterium, Rhizobium, and Serratia) in rhizosphere soil were enriched, which enhanced wheat resistance to Cd toxicity. These results showed that urease-producing and metal-immobilizing bacteria combined with sheep manure can inhibit the uptake of Cd by wheat.
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http://dx.doi.org/10.1016/j.chemosphere.2022.133534DOI Listing
April 2022

A Driving Method for Reducing Oil Film Splitting in Electrowetting Displays.

Membranes (Basel) 2021 Nov 24;11(12). Epub 2021 Nov 24.

College of Electron and Information, University of Electronic Science and Technology of China Zhongshan Institute, Zhongshan 528402, China.

Electrowetting displays (EWDs) are one of the most potential electronic papers. However, they have the problem of oil film splitting, which could lead to a low aperture ratio of EWDs. In this paper, a driving waveform was proposed to reduce oil film splitting. The driving waveform was composed of a rising stage and a driving stage. First, the rupture voltage of oil film was analyzed by testing the voltage characteristic curve of EWDs. Then, a quadratic function waveform with an initial voltage was applied at the rising stage to suppress oil film splitting. Finally, a square wave was applied at the driving stage to maintain the aperture ratio of EWDs. The experimental results show that the luminance was increased by 8.78% and the aperture ratio was increased by 4.47% compared with an exponential function driving waveform.
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http://dx.doi.org/10.3390/membranes11120920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707651PMC
November 2021

LMA® protector™ in patients undergoing laparoscopic surgeries: a multicenter prospective observational study.

BMC Anesthesiol 2021 12 20;21(1):318. Epub 2021 Dec 20.

Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Laryngeal masks airway (LMA) has been increasingly used in surgical patients. However, the use of LMA in laparoscopic surgeries remains controversial. The major concerns include the potential risk of esophageal regurgitation, aspiration, and difficulties to achieve effective ventilation. The aim of this study was to evaluate the safety and effectiveness of the LMA® Protector™ in patients undergoing laparoscopic surgery.

Methods: Patients aged 18 to 70 years, scheduled for laparoscopic surgeries were included. The insertion time, successful insertion rate, and oropharyngeal leak pressure were measured. Airway complications and airway manipulations during the procedure were documented. Effective ventilation rate was calculated. Visible bloodstains and reflux content in the drainage channel were documented after the removal of LMA® Protector™.

Results: Three hundred patients were enrolled. The insertion of LMA® Protector™ failed in seven patients resulting with a successful insertion rate of 97.7%. During the maintenance of anesthesia, airway manipulation was required in 19 patients (19/293, 6.48%), in three of whom the LMA was replaced with endotracheal intubation resulting with an effective ventilation rate of 96.7% (290/300). The oropharyngeal leak pressure was 30.18 ± 5.88 cmHO. Seventy-five patients (25.86%) reported mild sore throat on the first day after surgery. Bloodstains on study devices were noticed in 58 patients (20%). Seventy-five patients (25.86%) reported mild sore throat on the first day after surgery. Gastric reflux was noticed in the drainage tube in 5 patients (1.72%) with no signs of aspiration in any of those patients.

Conclusions: The LMA® Protector™ was shown to be safe and effective in patients undergoing laparoscopic surgeries. Although minor complications that require no further treatment, no clinically diagnosed aspiration was noticed in our study. Gastric reflux was noticed in the drainage tube in five patients undergoing laparoscopic gynecology surgery. Further research is needed to verify whether LMA® Protector™ is suitable for procedures in Trendelenburg position or other situations that a high risk of gastroesophageal reflux exists.

Trial Registration: The trial was registered at the Chinese Clinical Trial Registry ( ChiCTR1800018300 , date of registration: September 2018).
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http://dx.doi.org/10.1186/s12871-021-01535-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686540PMC
December 2021

Morphology library of nanosilica based on a thermally induced deformable template.

Chem Commun (Camb) 2022 Jan 4;58(3):443-446. Epub 2022 Jan 4.

School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China.

We report a versatile platform for the synthesis of shape-tunable nanosilica based on a thermally induced deformable template with diverse morphologies ranging from spheres, horns, ultrathin nanosheets, and rings to belts. This was realized by creating soft templates from a pair of anionic/cationic surfactants.
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http://dx.doi.org/10.1039/d1cc04402hDOI Listing
January 2022

Behavior Strategy Analysis Based on the Multi-Stakeholder Game under the Plastic Straw Ban in China.

Int J Environ Res Public Health 2021 12 2;18(23). Epub 2021 Dec 2.

Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of Education, Wuhan University of Science and Technology, Wuhan 430081, China.

Since 1 January 2021, China has banned nondegradable disposable straws in the catering industry. To promote the enforcement of the ban of plastic straws and improve the relationship between economic development and environmental protection, based on the evolutionary game method, this paper constructs the game model from the supply side and the demand side, respectively. Subsequently, through the dynamic equation, stable system evolution strategy is obtained. Furthermore, simulation is conducted to test the influence of the main parameters in the model on the evolution of system strategy. The results show that (1) the change of the government strategy mainly depends on its regulation costs and revenue, while the production strategy of a company is affected by the government and consumer strategies. (2) From the perspective of enterprise supply, government subsidies can promote technological innovation and develop new plastic straw substitutes. However, government penalties have little effect on violating enterprises. In addition, from the perspective of enterprise demand, with the collaboration of enterprises and consumers, it is easier for enterprises to carry out technological innovation. (3) Consumer acceptance of the substitutes for disposable plastic straws as well as online comments have a decisive influence on the enterprises' selections for research and development (R&D) strategies.
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http://dx.doi.org/10.3390/ijerph182312729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657267PMC
December 2021
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