Publications by authors named "Jianhui Wu"

223 Publications

Quantitative Evaluation of Aerosol Generation from Non-contact Tonometry and its Correlation with Tear Film Characteristics.

Adv Ther 2021 Apr 28. Epub 2021 Apr 28.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.

Introduction: Ophthalmologists are inevitably exposed to tears and ocular discharge during ophthalmologic examinations and are at high risk for SARS-CoV-2 infection. To understand the role of aerosols in disease transmission, we adopted a prospective cross-sectional study design and investigated the count and size distribution of aerosols generated by a non-contact tonometer and its correlation with individual tear film characteristics.

Methods: This study constituted two parts. The study population included outpatients who underwent an intraocular pressure examination in an intraocular pressure examination room (Part I) and 20 participants who underwent an intraocular pressure examination in a laboratory (Part II). The following main outcomes were measured: aerosol counts at 0, 50, 100, 150, and 200 cm from the non-contact tonometer (Part I); aerosol counts after each participant underwent non-contact tonometry, and lipid layer thickness score and tear film break-up time (Part II).

Results: The aerosol count decreased with increasing distance from the tonometer. The aerosol count at 0 cm had the highest value compared to that at other distances. For aerosols of diameters 0.25-0.5 μm and 0.5-1.0 μm, the count decreased at 50 cm and remained stable at further distances. For aerosols of diameters 1.0-2.5 μm and ≥ 2.5 μm, the count dropped progressively at all five distances. The aerosol count from each tonometer correlated positively with the lipid layer thickness score (r = 0.490, P = 0.028), whereas the aerosol count correlated negatively with the tear film break-up time (r =  - 0.675, P = 0.001).

Conclusions: Aerosols tended to coagulate during diffusion. A 50-cm distance from the tonometer could confer safety from aerosols with < 1.0-μm diameter. Aerosols generated during non-contact tonometry could contain a lipid layer component. Moreover, tear film stability could affect aerosol generation. Protective eyewear is recommended for reducing infection risk from aerosols. Individual tear film characteristics should be considered during non-contact tonometry.
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http://dx.doi.org/10.1007/s12325-021-01740-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080094PMC
April 2021

Analyses of production capacity of Sr and Sr in the 2 MW molten salt reactor.

Appl Radiat Isot 2021 Apr 3;173:109714. Epub 2021 Apr 3.

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; CAS Innovative Academies in TMSR Energy System, Chinese Academy of Sciences, Shanghai, 201800, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

The production capacity of Sr and Sr in the 2 MW MSR are evaluated. The gaseous Kr and Kr are extracted from the core through the helium bubbling system, and then decay to Sr and Sr, respectively. In order to improve purity of Sr product, two cooling devices are adopted in the Sr and Sr production system. The annual yields of Sr and Sr are about 9000 Ci and 32 Ci, respectively, and the impurity of Sr product is less than 2 ppm which can meet the medical requirement.
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http://dx.doi.org/10.1016/j.apradiso.2021.109714DOI Listing
April 2021

The Relationship Between Childhood Stress and Distinct Stages of Dynamic Behavior Monitoring in Adults: Neural and Behavioral Correlates.

Soc Cogn Affect Neurosci 2021 Apr 8. Epub 2021 Apr 8.

Center for Brain Disorder and Cognitive Science, Shenzhen University, Shenzhen, 518060 China.

Childhood adversity is a major risk factor for emotional and cognitive disorders later in adulthood. Behavior monitoring, one of the most important components of cognitive control, plays a crucial role in flexible interaction with the environment. Here, we test a novel conceptual model discriminating between two distinct dimensions of childhood adversity (i.e., deprivation and threat) and examine their relations to dynamic stages of behavior monitoring. Sixty young healthy adults participated in this study using event-related potentials (ERPs) and the dynamic stages of behavior monitoring including response inhibition, error detection, and post-error adjustments were investigated in a classical Go/NoGo task. Multiple regression analyses revealed that participants with higher severity of childhood adversity recruited more controlled attention, as indicated by larger (more negative) conflict detection-related NoGo-N2 amplitudes and larger (more negative) error detection-related ERN amplitudes. Higher severity of childhood abuse (an indicator of threat) was related to smaller (less positive) error appraisal-related Pe amplitudes on the neural level and subsequently lower post-error accuracy on the behavioral level. These results suggested that prefrontal-supported controlled attention is influenced by universal adversity in childhood while the error-related behavioral adjustment is mainly affected by childhood abuse, indicating the dimensions of deprivation and threat are at least partially distinct.
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http://dx.doi.org/10.1093/scan/nsab041DOI Listing
April 2021

Characterization and Toxicity of Crude Toxins Produced by against (Gennadius) and (Koch).

Toxins (Basel) 2021 03 18;13(3). Epub 2021 Mar 18.

Key Laboratory of Bio-Pesticide Innovation and Application, Guangzhou 510642, China.

, an insect pathogenic fungus, produces different toxins/secondary metabolites which can act as pest control agents. This study reports the extraction and characterization of crude mycelial extracts of isolate SP502 along with their bio-efficacy against and . Fourier transform infrared spectroscopy, liquid chromatography, mass spectrometery and nuclear magnetic resonance analysis of isolate SP502 extracts showed the presence of five major compounds-Trichodermin, 5-Methylmellein, Brevianamide F, Enniatin and Beauvericin-which all may potentially be involved in insecticidal activity. The HPLC analysis of mycelial extracts and Beauvericin standard showed similar chromatographic peaks, with the content of Beauvericin in the crude toxin being calculated as 0.66 mg/ml. The median lethal concentrations of mycelial extracts towards first, second, third and fourth instar nymphs of were 46.35, 54.55, 68.94, and 81.92 µg/mL, respectively. The median lethal concentrations of mycelial extracts towards first, second, third and fourth instar nymphs of were 62.67, 72.84, 77.40, and 94.40 µg/mL, respectively. Our results demonstrate that bioactive compounds produced by isolate SP502 have insecticidal properties and could, therefore, be developed into biopesticides for the management of and .
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http://dx.doi.org/10.3390/toxins13030220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003032PMC
March 2021

The mediating effect of media usage on the relationship between anxiety/fear and physician-patient trust during the COVID-19 pandemic.

Psychol Health 2021 Mar 23:1-20. Epub 2021 Mar 23.

School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.

Objective: Our study explored whether and how media usage can mediate the path from anxiety and fear to physician-patient trust.

Design: Study 1 was a population-based, longitudinal study using nationally representative data from 29 provinces in mainland China. The baseline sample ( = 3233) was obtained from February 1 to 9, 2020. Follow-up ( = 1380) took place during March 17 to 24, 2020. Study 2 was a machine learning-based sentiment analysis in which data were captured from Sina Weibo, a Chinese microblogging website, among the most popular official, unofficial, and health-related media accounts. The screened blogs from November to December 2019 and February to March 2020 were scored by Google APIs for positivity and magnitude.

Main Outcome Measures: Physician-patient trust.

Results: Study 1 showed fear and anxiety affected changes in physician-patient trust through media usage, the indirect effect of which was 0.14 (0.03) and the 95% CI was [0.08, 0.19]. Study 2 indicated a more positive image of physicians after the outbreak compared to before [ (2, 3537) = 3.646,  = 0.026, partial =0.002].

Conclusion: The negative impact of anxiety and fear on physician-patient trust was mediated by media use, which can be explained by the more positive media image during the pandemic.
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http://dx.doi.org/10.1080/08870446.2021.1900573DOI Listing
March 2021

Identification of an Immune-Related Signature for Predicting Prognosis in Patients With Pancreatic Ductal Adenocarcinoma.

Front Oncol 2020 24;10:618215. Epub 2021 Feb 24.

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing, China.

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is one of the highest fatality rate cancers with poor survival rates. The tumor microenvironment (TME) is vital for tumor immune responses, leading to resistance to chemotherapy and poor prognosis of PDAC patients. This study aimed to provide a comprehensive evaluation of the immune genes and microenvironment in PDAC that might help in predicting prognosis and guiding clinical treatments.

Methods: We developed a prognosis-associated immune signature (i.e., PAIS) based on immune-associated genes to predict the overall survival of patients with PDAC. The clinical significance and immune landscapes of the signature were comprehensively analyzed.

Results: Owing to gene expression profiles from TCGA database, functional enrichment analysis revealed a significant difference in the immune response between PDAC and normal pancreas. Using transcriptome data analysis of a training set, we identified an immune signature represented by 5 genes (ESR2, IDO1, IL20RB, PPP3CA, and PLAU) related to the overall survival of patients with PDAC, significantly. This training set was well-validated in a test set. Our results indicated a clear association between a high-risk score and a very poor prognosis. Stratification analysis and multivariate Cox regression analysis revealed that PAIS was an important prognostic factor. We also found that the risk score was positively correlated with the inflammatory response, antigen-presenting process, and expression level of some immunosuppressive checkpoint molecules (e.g., CD73, PD-L1, CD80, and B7-H3). These results suggested that high-risk patients had a suppressed immune response. However, they could respond better to chemotherapy. In addition, PAIS was positively correlated with the infiltration of M2 macrophages in PDAC.

Conclusions: This study highlighted the relationship between the immune response and prognosis in PDAC and developed a clinically feasible signature that might serve as a powerful prognostic tool and help further optimize the cancer therapy paradigm.
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http://dx.doi.org/10.3389/fonc.2020.618215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945593PMC
February 2021

Refined mapping of stripe rust resistance gene YrP10090 within a desirable haplotype for wheat improvement on chromosome 6A.

Theor Appl Genet 2021 Mar 8. Epub 2021 Mar 8.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.

Key Message: A large genomic region spanning over 300 Mb on chromosome 6A under intense artificial selection harbors multiple loci associated with favorable traits including stripe rust resistance in wheat. The development of resistance cultivars can be an optimal strategy for controlling wheat stripe rust disease. Although loci for stripe rust resistance have been identified on chromosome 6A in previous studies, it is unclear whether these loci span a common genetic interval, and few studies have attempted to analyze the haplotype changes that have accompanied wheat improvement over the period of modern breeding. In this study, we used F families and F recombinant inbred lines (RILs) derived from a cross between a resistant CIMMYT wheat accession P10090 and the susceptible landrace Mingxian 169 to improve the resolution of the QTL on chromosome 6A. The co-located QTL, designated as YrP10090, was flanked by SNP markers AX-94460938 and AX-110585473 with a genetic interval of 3.5 cM, however, corresponding to a large physical distance of over 300 Mb in RefSeq v.1.0 (positions 107.1-446.5 Mb). More than 1,300 SNP markers in this genetic region were extracted for haplotype analysis in a panel of 1,461 worldwide common wheat accessions, and three major haplotypes (Hap1, Hap2, and Hap3) were identified. The favorable haplotype Hap1 associated with stripe rust resistance exhibited a large degree of linkage disequilibrium. Selective sweep analyses were performed between different haplotype groups, revealing specific genomic regions with strong artificial selection signals. These regions harbored multiple desirable traits associated with resilience to environmental stress, different yield components, and quality characteristics. P10090 and its derivatives that carry the desirable haplotype can provide a concrete foundation for bread wheat improvement including the genomic selection.
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http://dx.doi.org/10.1007/s00122-021-03801-6DOI Listing
March 2021

An inverted U-shaped relationship between cortisol awakening response and same-day error monitoring function in healthy males.

Biol Psychol 2021 03 16;160:108052. Epub 2021 Feb 16.

Department of Psychology, University of Westminster, London, UK.

The cortisol awakening response (CAR) is thought to provide an energetic "boost" for the coming day and has been shown to be associated with prefrontal dependent function. The aim of the current study was to examine the relationship between the CAR and same-day neural activity following an error response task. Forty-six healthy males (22.25 years ± 1.98) collected saliva samples at 0, 30 and 45 min post-awakening to measure the CAR, and on the same afternoon event-related potential activity during error processing was measured. Although no association was observed between CAR and post-error behavior, a significant quadratic relationship was observed between CAR and Error-related Negativity (ERN) amplitude, and this association remained while controlling for confounding factors. This finding suggested the existence of an inverted U-shaped relationship between CAR and the same-day error-monitoring function in healthy males.
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http://dx.doi.org/10.1016/j.biopsycho.2021.108052DOI Listing
March 2021

Fabrication of single-nanometer metallic gaps via spontaneous nanoscale dewetting.

Nanotechnology 2021 May;32(20):205302

College of Mechanical and Vehicle Engineering, National Engineering Research Centre for High Efficiency Grinding, Hunan University, Changsha 410082, People's Republic of China.

Ultrasmall metallic nanogaps are of great significance for wide applications in various nanodevices. However, it is challenging to fabricate ultrasmall metallic nanogaps by using common lithographic methods due to the limited resolution. In this work, we establish an effective approach for successful formation of ultrasmall metallic nanogaps based on the spontaneous nanoscale dewetting effect during metal deposition. By varying the initial opening size of the exposed resist template, the influence of dewetting behavior could be adjusted and tiny metallic nanogaps can be obtained. We demonstrate that this method is effective to fabricate diverse sub-10 nm gaps in silver nanostructures. Based on this fabrication concept, even sub-5 nm metallic gaps were obtained. SERS measurements were performed to show the molecular detection capability of the fabricated Ag nanogaps. This approach is a promising candidate for sub-10 nm metallic gaps fabrication, thus possessing potential applications in nanoelectronics, nanoplasmonics, and nano-optoelectronics.
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http://dx.doi.org/10.1088/1361-6528/abe576DOI Listing
May 2021

An association between cumulative exposure to light at night and the prevalence of hyperuricemia in steel workers.

Int J Occup Med Environ Health 2021 Feb 4. Epub 2021 Feb 4.

North China University of Science and Technology, Tangshan, China (School of Public Health).

Objectives: Exposure to light at night (LAN) can disturb circadian endocrine and metabolic rhythms. Hyperuricemia (HUA) is an early-onset metabolic disorder. However, it is still not clear whether LAN exposure increases the prevalence of HUA.

Material And Methods: The authors used crosssectional data on the Beijing-Tianjin-Hebei occupational populations cohort from March-July 2017. A total of 7664 steel workers were finally selected to investigate the relationship between LAN exposure and the prevalence of HUA among steel workers. The authors collected demographic and socio-economic data, as well as information on lifestyle factors, anthropometric measures, and laboratory tests. The restricted cubic spline method was used to analyze the dose-response relationship between cumulative LAN exposure and the prevalence of HUA. Logistic regression analyses were used to fit the relationship between them.

Results: The average age of the participants was 43.5±8.6 years; 7051 (91.7%) of them were males, 2749 (35.9%) reported to suffer from HUA, and 1241 (16.2%) were not exposed to LAN. There was a significant non-linear dose-response relationship between them. After adjustment for the confounding factors, including demographic data, lifestyle factors, etc., the lower LAN exposure was significantly associated with HUA (0-1931.7 days, OR = 1.180, and the 95% CI: 1.000-1.394; 1931.7-4343 days, OR: 1.215, 95% CI: 1.035-1.426).

Conclusions: This study revealed that a certain amount of exposure to LAN is independently related to the prevalence of HUA in steel workers in China.
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http://dx.doi.org/10.13075/ijomeh.1896.01648DOI Listing
February 2021

Primary Carbonaceous Particle Emission from Four Power Plants with Ultralow Emission in China.

ACS Omega 2021 Jan 7;6(2):1309-1315. Epub 2021 Jan 7.

State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.

Particulate matters (PMs) were collected in stacks from two types of ultralow emission coal-fired power plants by a heated electrical low-pressure impactor (HT-ELPI), including ultralow emission pulverized combustion technology boilers (ULPCBs) and ultralow emission circulating fluidized bed boilers (ULCFBs). The characteristics of organic carbon (OC) and elemental carbon (EC) in size-resolved particles were analyzed. The ultralow emission technologies significantly decreased the mass concentrations of the carbonaceous content, and the emission concentrations of OC and EC ranged from 5.64 to 17.9 μg/m for ULPCBs and from 0.57 to 1.85 μg/m for ULCFBs. However, the number concentration of particles was not significantly decreased in the four ultralow emission power plants. The OC in the particle emission of ULPCBs presents a bimodal size distribution with the particle size, while three successive unimodal distributions were observed in the ULCFB emission. Compared to ULPCBs, much more char-EC and soot-EC condensed in the particles, which were collected from ULCFBs. Furthermore, the char-EC/soot-EC in the particle fractions of ULPCBs characterized by the "V" type with the sequence of PM > PM > PM, differing from the PM > PM > PM of ULCFBs. The ratios of OC/EC in the stacks from two types of boilers did not show obvious variations in particle size distributions, and the mean OC/EC was far higher than those for non-ultralow emission power plants. Considering the impact of OC, OC, and EC, the ratio of high-temperature organic carbon (HTOC, defined as OC + OC) and soot-EC was studied. The HTOC/soot-EC increased with the increase of RH in the stack, and the highest HTOC/soot-EC values were obtained from ULPCBs (33.0% (PM), 11.4% (PM), and 23.9% (PM)). Meanwhile, strong correlations (0.69-0.85, < 0.001) between HTOC and soot-EC were obtained, implying that HTOC and soot-EC probably simultaneously condensed in the purification equipment.
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http://dx.doi.org/10.1021/acsomega.0c04754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818619PMC
January 2021

The distribution pattern of periprostatic neurovascular bundles examined with successive celloidin slices.

BMC Urol 2021 Jan 6;21(1). Epub 2021 Jan 6.

Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, China.

Background: Although several distribution patterns of periprostatic neurovascular bundles have been proposed, variant dissection technique based on these patterns still confused surgeons. The aim of this study was to describe the periprostatic neurovascular bundles and their relationship with the fascicles around prostate and provide the accurate morphologic knowledge of periprostatic tissue for prostate operation.

Methods: The pelvic viscera were obtained from 26 adult male cadavers. They were embedded in celloidin and cut into successive slices. The slices were explored with anatomic microscopy. 3-Dimensional reconstruction was achieved with celloidin sections and series software.

Results: The prostatic capsule which surrounded the dorsal, bilateral aspect of the prostate was attached ventrally to anterior fibrous muscular stroma (AFMS). The lower part of the striated sphincter completely embraced the urethral; the upper part of this muscle covered the lower ventral surface of prostate. The upper ventral surface of prostate is covered by the circular muscle of detrusor. The levator fascia and the capsule adhered on the most convex region of the lateral prostate, but separated on the other region. The pelvic neurovascular bundles (PNVB) divided into the anterior and posterior divisions. The anterior division continued as dorsal vascular complex (DVC). The distal part of DVC entered into penile hilum. The posterior division continued as neurovascular bundles, and then as the cavernous supply (CS). The distal part of CS joined into pudendal neurovascular bundles.

Conclusions: The capsule and AFMS formed a pocket like complex. There were anterior and posterior neurovascular approaches from PNVB to penile hilum.
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http://dx.doi.org/10.1186/s12894-020-00778-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789796PMC
January 2021

CD26 as a Promising Biomarker for Predicting Prognosis in Patients with Pancreatic Tumors.

Onco Targets Ther 2020 8;13:12615-12623. Epub 2020 Dec 8.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China.

Purpose: Pancreatic cancer is associated with a high mortality rate owing to insufficient approaches for early diagnosis and the invasive biological behavior of the cancer. CD26 is a membrane-anchored protein involved in multiple physiological and pathological processes. Here, we investigated correlations between CD26 expression and clinicopathological features in patients with pancreatic tumors.

Methods: We collected 170 tumor tissue specimens and 138 paired paratumoral tissues from patients with pancreatic tumors and evaluated CD26 expression using immunohistochemistry.

Results: CD26 was expressed in 79.4% of pancreatic tumors, which was significantly ( < 0.001) higher than that in paratumoral pancreatic tissues (23.2%). High expression of CD26 was correlated with ABO blood type ( = 0.035), malignancy degree ( = 0.001), CA199 ( = 0.01), and CA242 ( = 0.027). In pancreatic malignancies, CD26 expression was observed in 80.7% (130/161) of cases. Lower CD26 expression was correlated with longer disease-free survival ( = 0.048) and overall survival ( = 0.024) and was an independent predictor of overall survival (hazard ratio [HR]: 1.713; = 0.042). Similar results were observed in pancreatic ductal adenocarcinoma (PDAC) tissues, and CD26 expression level (HR: 2.117; = 0.008) was an independent predictor of overall survival in patients with PDAC. CD26 expression was significantly increased in pancreatic tumors and gradually increased with increasing malignancy degree, suggesting that CD26 may be involved in the tumorigenic proliferation of pancreatic tumors.

Conclusion: Therefore, CD26 is a potential marker for early diagnosis and a promising therapeutic target in pancreatic tumors.
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http://dx.doi.org/10.2147/OTT.S278736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737554PMC
December 2020

Long Noncoding RNA AFAP1-AS1 Is a Critical Regulator of Nasopharyngeal Carcinoma Tumorigenicity.

Front Oncol 2020 23;10:601055. Epub 2020 Nov 23.

Department of Radiation Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Background: The long noncoding RNA actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is a critical player in various cancers. However, the clinical value and functional mechanisms of AFAP1-AS1 during the tumorigenicity of nasopharyngeal carcinoma (NPC) remain unclear. Here, we investigated the clinical application and potential molecular mechanisms of AFAP1-AS1 in NPC tumorigenesis and progression.

Methods: The expression level of AFAP1-AS1 was determined by qRT-PCR in 10 paired fresh human NPC tissues and adjacent normal tissues. RNAscope was performed on 100 paired paraffin-embedded NPC and adjacent nontumor specimens. The biological functions of AFAP1-AS1 were assessed by and functional experiments. RNA-protein pull-down assays were performed to detect and identify the AFAP1-AS1-interacting protein KAT2B. Protein-RNA immunoprecipitation (RIP) assays were conducted to examine the interaction of AFAP1-AS1 and KAT2B. Chromatin immunoprecipitation (ChIP) and luciferase analyses were utilized to identify the binding site of transcription intermediary factor 1 alpha (TIF1α) and H3K14ac on the RBM3 promoter.

Results: AFAP1-AS1 is upregulated in NPC and is a poor prognostic indicator for survival in NPC patients. AFAP1-AS1 was required for NPC proliferation and tumorigenicity . Mechanistic investigations suggested that AFAP1-AS1 binds to KAT2B and promotes acetyltransferase activation at two residues (E570/D610). KAT2B further promotes H3K14 acetylation and protein binding to the bromo domain of TIF1α. Consequently, TIF1α acts as a nuclear transcriptional coactivator of RBM3 transcription, leading to YAP mRNA stabilization and enhanced NPC tumorigenicity.

Conclusions: Our findings suggest that AFAP1-AS1 functions as an oncogenic biomarker and promotes NPC tumorigenicity through enhanced KAT2B acetyltransferase activation and YAP mRNA stabilization.
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http://dx.doi.org/10.3389/fonc.2020.601055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719841PMC
November 2020

Development and internal validation of risk prediction model of metabolic syndrome in oil workers.

BMC Public Health 2020 Nov 30;20(1):1828. Epub 2020 Nov 30.

School of Public Health, North China University of Science and Technology, No.21 Bohai Avenue, Caofeidian New Town, Tangshan City, Hebei Province, 063210, P.R. China.

Background: The prevalence of metabolic syndrome continues to rise sharply worldwide, seriously threatening people's health. The optimal model can be used to identify people at high risk of metabolic syndrome as early as possible, to predict their risk, and to persuade them to change their adverse lifestyle so as to slow down and reduce the incidence of metabolic syndrome.

Methods: Design existing circumstances research. A total of 1468 workers from an oil company who participated in occupational health physical examination from April 2017 to October 2018 were included in this study. We established the Logistic regression model, the random forest model and the convolutional neural network model, and compared the prediction performance of the models according to the F1 score, sensitivity, accuracy and other indicators of the three models.

Results: The results showed that the accuracy of the three models was 82.49,95.98 and 92.03%, the sensitivity was 87.94,95.52 and 90.59%, the specificity was 74.54, 96.65 and 94.14%, the F1 score was 0.86,0.97 and 0.93, and the area under ROC curve was 0.88,0.96 and 0.92, respectively. The Brier score of the three models was 0.15, 0.08 and 0.12, Observed-expected ratio was 0.83, 0.97 and 1.13, and the Integrated Calibration Index was 0.075,0.073 and 0.074, respectively, and explained how the random forest model was used for individual disease risk score.

Conclusions: The study showed that the prediction performance of random forest model is better than other models, and the model has higher application value, which can better predict the risk of metabolic syndrome in oil workers, and provide corresponding theoretical basis for the health management of oil workers.
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http://dx.doi.org/10.1186/s12889-020-09921-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706262PMC
November 2020

Biological Impact and Enzyme Activities of (Lepidoptera: Noctuidae) in Response to Synergistic Action of Matrine and .

Front Physiol 2020 2;11:584405. Epub 2020 Nov 2.

Key Laboratory of Bio-Pesticide Innovation and Application, Engineering Research Centre of Biological Control, South China Agricultural University, Guangzhou, China.

Matrine, a naturally occurring heterocyclic compound, has been shown to enhance the pathogenicity of the entomopathogenic fungus against . In the current study, the biological impacts and synergism activities of these two agents on nutritional efficiency and antioxidant enzymes in were explored. Our results showed a high antifeedant activity of and matrine on . The larvae were unable to pupate and emerge when treated with combinations of matrine and . Following on, we measured the activities of five important antioxidant enzymes [superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), acetylcholinesterase (AChE), and glutathione-S-transferase (GST)] when treated with SB010 (1 × 10 spores/ml), matrine (0.5 mg/ml), and SB010 (1 × 10 spores/ml) + matrine (0.5 mg/ml). The results indicated the detoxification activity of the five enzymes in the fat body and hemolymph of when facing a combined and matrine challenge. The activities of the enzymes were significantly lower than that of the control group 7 days post-treatment, indicating the inhibitory effect of the two xenobiotics. Matrine had better inhibition effects than in a majority of the trials. The improved detoxification activity of the five enzymes may be the internal mechanism of synergism of matrine on .
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http://dx.doi.org/10.3389/fphys.2020.584405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667252PMC
November 2020

Changes in source contributions to particle number concentrations after the COVID-19 outbreak: Insights from a dispersion normalized PMF.

Sci Total Environ 2021 Mar 6;759:143548. Epub 2020 Nov 6.

Center for Air Resources Engineering and Science, Clarkson University, Potsdam, NY 13699, USA; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Factor analysis models use the covariance of measured variables to identify and apportion sources. These models, particularly positive matrix factorization (PMF), have been extensively used for analyzing particle number concentrations (PNCs) datasets. However, the variation of observed PNCs and particle size distribution are driven by both the source emission rates and atmospheric dispersion as well as chemical and physical transformation processes. This variation in the observation data caused by meteorologically induced dilution reduces the ability to obtain accurate source apportionment results. To reduce the influence of dilution on quantitative source estimates, a methodology for improving the accuracy of source apportionment results by incorporating a measure of dispersion, the ventilation coefficient, into the PMF analysis (called dispersion normalized PMF, DN-PMF) was applied to a PNC dataset measured from a field campaign that includes the Spring Festival event and the start of the COVID-19 lockdown in Tianjin, China. The data also included gaseous pollutants and hourly PM compositional data. Eight factors were resolved and interpreted as municipal incinerator, traffic nucleation, secondary inorganic aerosol (SIA), traffic emissions, photonucleation, coal combustion, residential heating and festival emissions. The DN-PMF enhanced the diel patterns of photonucleation and the two traffic factors by enlarging the differences between daytime peak values and nighttime concentrations. The municipal incinerator plant, traffic emissions, and coal combustion have cleaner and more clearly defined directionalities after dispersion normalization. Thus, dispersion normalized PMF is capable of enhancing the source emission patterns. After the COVID-19 lockdown began, PNC of traffic nucleation and traffic emissions decreased by 41% and 44%, respectively, while photonucleation produced more particles likely due to the reduction in the condensation sink. The significant changes in source emissions indicate a substantially reduced traffic volume after the implement of lockdown measures.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647391PMC
March 2021

The relationship between perceived stress and emotional distress during the COVID-19 outbreak: Effects of boredom proneness and coping style.

J Anxiety Disord 2021 01 29;77:102328. Epub 2020 Oct 29.

Center for Brain Disorder and Cognitive Science, Shenzhen University, Shenzhen, 518060 China; Shenzhen Institute of Neuroscience, Shenzhen 518057, China; Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands. Electronic address:

The outbreak of a novel coronavirus (COVID-19) pandemic was a great threat to the physical and mental health of the general population. Our research aimed to investigate the relationship between perceived stress and emotional distress during the initial outbreak. Furthermore, potential risks and protective factors, i.e., coping and boredom proneness, of stress-related emotional distress were also explored. Data from 3233 participants in China were collected through an online survey platform during the initial outbreak of the COVID-19 from January 31 to February 9 in 2020. Results showed that higher perceived stress was associated with more emotional distress including depression, fear, compulsion-anxiety, neurasthenia, and hypochondria. Boredom proneness significantly and positively mediated the relationship between perceived stress and emotional distress. Moreover, coping style moderated the stress-emotional distress relationship, i.e., individuals who mainly adopted positive coping strategies suffered fewer symptoms of depression, compulsion-anxiety, and neurasthenia under stress, while negative coping strategies aggravated emotional distress. These results from the present study provide practical value for mental health intervention during the emergent public health events.
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http://dx.doi.org/10.1016/j.janxdis.2020.102328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598556PMC
January 2021

Chemical characteristics and sources of ambient PM in a harbor area: Quantification of health risks to workers from source-specific selected toxic elements.

Environ Pollut 2021 Jan 25;268(Pt B):115926. Epub 2020 Oct 25.

Center for Air Resources Engineering and Science, Clarkson University, Potsdam, NY, 13699, USA; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.

Samples of ambient PM were collected in the Qingdao harbor area between 21 March and May 25, 2016, and analyzed to investigate the compositions and sources of PM and to assess source-specific selected toxic element health risks to workers via a combination of positive matrix factorization (PMF) and health risk (HR) assessment models. The mean concentration of PM in harbor area was 48 μg m with organic matter (OM) dominating its mass. Zn and V concentrations were significantly higher than the other selected toxic elements. The hazard index (HI) and cancer risk (R) of all selected toxic elements were lower than the United States Environmental Protection Agency (USEPA) limits. There were no non-cancer and cancer risks for workers in harbor area. The contributions from industrial emissions (IE), ship emissions (SE), vehicle emissions (VE), and crustal dust and coal combustion (CDCC) to selected toxic elements were 39.0%, 12.8%, 24.0%, and 23.0%, respectively. The HI values of selected toxic elements from IE, CDCC, SE, and VE were 1.85 × 10, 7.08 × 10, 6.36 × 10, and 3.37 × 10, respectively; these are lower than the USEPA limits. The total cancer risk (R) value from selected toxic elements in CDCC was 2.04 × 10, followed by IE (6.40 × 10), SE (2.26 × 10), and VE (2.18 × 10). CDCC and IE were the likely sources of cancer risk in harbor area. The Bo Sea and coast were identified as the likely source areas for health risks from IE via potential source contribution function (PSCF) analysis based on the results of PMF-HR modelling. Although the source-specific health risks were below the recommended limit values, this work illustrates how toxic species in PM health risks can be associated with sources such that control measures could be undertaken if the risks warranted it.
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http://dx.doi.org/10.1016/j.envpol.2020.115926DOI Listing
January 2021

[Clinical investigation on the related factors for the application of systemic glucocorticoids in patients with acute exacerbation of chronic obstructive pulmonary disease with carbon dioxide retention].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Sep;32(9):1061-1066

Department of Pulmonary and Critical Care Medicine, Ningde Municipal Hospital of Fujian Medical University (Ningde Municipal Hospital of Ningde Normal University), Ningde 352100, Fujian, China. Corresponding author: Wu Jianhui, Email:

Objective: To investigate the factors affecting the application of systemic glucocorticoids in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with carbon dioxide (CO) retention, and to guide the formulation of a strategy to reduce systemic glucocorticoid exposure.

Methods: The AECOPD patients with CO retention admitted to the Ningde Municipal Hospital of Fujian Medical University from January 2017 to December 2019 were enrolled. The general information, past history, times of acute exacerbations within 1 year, pneumonia on admission, causes of COPD, heart failure, blood gas analysis, eosinophil count (EOS), albumin (Alb) and apolipoprotein E (ApoE) levels, exhaled nitric oxide (FeNO) level, inhaled glucocorticoid and non-invasive mechanical ventilation treatment at acute exacerbation were collected. The patients were divided into recommended dosage group (exposure levels in the recommended dosage range, cumulative prednisone dosage ≤ 200 mg) and exceeded group (exposure levels exceeded the recommended dose, cumulative prednisone dosage > 200 mg) according to cumulative systemic glucocorticoid exposure dosage of the patients during hospitalization. The clinical data of patients between the two groups were compared, and possible factors with P < 0.1 in univariate analysis were included in multivariate Logistic regression analysis to screen the related factors of systemic glucocorticoid exposure level in AECOPD patients with CO retention.

Results: According to the order of hospitalization, 151 AECOPD patients with CO retention were enrolled, 8 patients were excluded, and 143 patients were enrolled in the analysis. Of the 143 patients, 68 received the recommended dose of systemic glucocorticoid, and 75 received excessive systemic glucocorticoid. Age, percentage of forced expiratory volume in 1 second (FEV1%) at stable phase, frequency of acute exacerbation within 1 year, heart failure ratio, oxygen index (PaO/FiO), arterial partial pressure of carbon dioxide (PaCO), serum EOS and ApoE levels at admission, the ratio of aerosolized inhaled glucocorticoids and non-invasive mechanical ventilation showed statistical differences between the two groups. Multivariate Logistic regression analysis showed that related factors affecting systemic glucocorticoid exposure levels of AECOPD patients with CO retention were FEV1% at stable phase [odds ratio (OR) = 0.957, 95% confidence interval (95%CI) was 0.921-0.994, P = 0.023], acute exacerbation frequency within 1 year (OR = 1.530, 95%CI was 1.121-2.088, P = 0.007), heart failure (OR = 3.022, 95%CI was 1.263-7.231, P = 0.013), PaCO (OR = 1.062, 95%CI was 1.010-1.115, P = 0.018) and EOS at admission (OR = 0.103, 95%CI was 0.016-0.684, P = 0.019), aerosolized inhaled glucocorticoids (OR = 0.337, 95%CI was 0.145-0.783, P = 0.011) and non-invasive mechanical ventilation at acute exacerbation (OR = 0.422, 95%CI was 0.188-0.948, P = 0.037), of which high FEV1% at stable phase, high EOS at admission, aerosolized inhaled glucocorticoid and non-invasive mechanical ventilation at acute exacerbation were protective factors, while high frequency of acute exacerbation within 1 year, heart failure and high PaCO were risk factors.

Conclusions: For AECOPD patients with CO retention, high FEV1% at stable phase, high EOS level at admission, aerosolized inhaled glucocorticoid and non-invasive mechanical ventilation at acute exacerbation can reduce systemic glucocorticoid exposure. In addition, high frequency of acute exacerbation within 1 year, heart failure, and high PaCO can increase systemic glucocorticoid exposure.
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http://dx.doi.org/10.3760/cma.j.cn121430-20200302-00203DOI Listing
September 2020

A novel nomogram for predicting local recurrence-free survival after surgical resection for retroperitoneal liposarcoma from a Chinese tertiary cancer center.

Int J Clin Oncol 2021 Jan 17;26(1):145-153. Epub 2020 Oct 17.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing, People's Republic of China.

Background: Local recurrence is the most difficult postoperative challenge and the leading cause of death in patients with retroperitoneal liposarcoma (RLPS). We aimed to establish a postoperative nomogram exclusively focused on RLPS for predicting local recurrence-free survival (LRFS).

Methods: A cohort of 124 patients after surgical resection with curative intent in the Peking University Cancer Hospital Sarcoma Center were included in the study. Demographic, clinicopathologic, and treatment variables were analyzed using the Cox regression model. Significant clinically relevant variables in multivariable analysis were incorporated into the RLPS-specific nomogram. The discriminative ability and predictive accuracy of the nomogram were assessed by calculating the concordance index and drawing a calibration plot.

Results: At a median follow-up of 26.5 (interquartile range 10.9-39.4) months, 71 patients had recurrent disease. The 3-year and 5-year LRFS rates were 35.6% (95% confidence interval, 27.0-46.9%) and 28.2% (95% CI 15.8-38.6%), respectively. Multivariate analysis identified the French Federation of Cancer Centers Sarcoma Group (FNCLCC) grade and completeness of resection as independent predictors of LRFS. Variables included in our nomogram were: presentation status, multifocality, completeness of resection, histologic subtypes, and FNCLCC grade. The concordance index of our nomogram was 0.732 (95% CI 0.667-0.797) and the calibration plot was excellent.

Conclusions: Our novel nomogram for patients with resected RLPS could improve recurrence risk stratification to explore molecular analysis associated with recurrence.
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http://dx.doi.org/10.1007/s10147-020-01796-6DOI Listing
January 2021

Develop and Evaluate a New and Effective Approach for Predicting Dyslipidemia in Steel Workers.

Front Bioeng Biotechnol 2020 10;8:839. Epub 2020 Sep 10.

School of Public Health, North China University of Science and Technology, Tangshan, China.

The convolutional neural network (CNN) has made certain progress in image processing, language processing, medical information processing and other aspects, and there are few relevant researches on its application in disease risk prediction. Dyslipidemia is a major and modifiable risk factor for cardiovascular disease, early detection of dyslipidemia and early intervention can effectively reduce the occurrence of cardiovascular diseases. Risk prediction model can effectively identify high-risk groups and is widely used in public health and clinical medicine. Steel workers are a special occupational group. Their particular occupational hazards, such as high temperatures, noise and shift work, make them more susceptible to disease than the general population, which makes the risk prediction model for the general population no longer applicable to steel workers. Therefore, it is necessary to establish a new model dedicated to the prediction of dyslipidemia of steel workers. In this study, the physical examination information of thousands of steel workers was collected, and the risk factors of dyslipidemia in steel workers were screened out. Then, based on the data characteristics, the corresponding parameters were set for the convolutional neural network model, and the risk of dyslipidemia in steel workers was predicted by using convolutional neural network. Finally, the predictive performance of the convolutional neural network model is compared with the existing predictive models of dyslipidemia, logistics regression model and BP neural network model. The results show that the convolutional neural network has a good predictive performance in the risk prediction of dyslipidemia of steel workers, and is superior to the Logistic regression model and BP neural network model.
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http://dx.doi.org/10.3389/fbioe.2020.00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513671PMC
September 2020

Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway.

Sci Rep 2020 09 25;10(1):15729. Epub 2020 Sep 25.

Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, NO. 10, Youanmenwaixitoutiao, Fengtai District, Beijing, 100069, China.

The coupling of Arg-Gly-Asp-Val (RGDV) and gemcitabine led to a hypothesis that the conjugate (RGDV-gemcitabine) could inhibit tumor metastasis. To confirm this hypothesis the activities of RGDV-gemcitabine inhibiting tumor metastasis in vitro and in vivo were presented for the first time. AFM (atomic force microscopy) imaged that RGDV-gemcitabine was able to adhere onto the surface of serum-starved A549 cells, to block the extending of the pseudopodia. Thereby RGDV-gemcitabine was able to inhibit the invasion, migration and adhesion of serum-starved A549 cells in vitro. On C57BL/6 mouse model RGDV-gemcitabine dose dependently inhibited the metastasis of planted tumor towards the lung and the minimal dose was 0.084 µmol/kg/3 days. The decrease of serum TNF-α (tumor necrosis factor), IL-8 (interleukin-8), MMP-2 (matrix metalloprotein-2) and MMP-9 (matrix metalloprotein-9) of the treated C57BL/6 mice was correlated with the action pathway of RGDV-gemcitabine inhibiting the metastasis of the planted tumor towards lung.
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http://dx.doi.org/10.1038/s41598-020-72824-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519057PMC
September 2020

Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma.

Am J Pathol 2020 12 22;190(12):2343-2354. Epub 2020 Sep 22.

Department of Radiation Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, PR China. Electronic address:

The long noncoding RNA DANCR (differentiation antagonizing non-protein coding RNA) displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in nasopharyngeal carcinoma (NPC) remain poorly understood. We found that DANCR is dramatically up-regulated in human NPC, and that it is an indicator for poor survival prognosis. DANCR knockdown suppressed cell proliferation, colony formation in vitro, and tumorigenicity in vivo. Mechanistic analyses demonstrated that DANCR could bind to RNA-binding protein 3 (RBM3) protein and stabilize SOX2 mRNA, resulting in NPC cell proliferation. Our findings indicate that DANCR functions as an oncogene and a potential therapeutic target for NPC.
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http://dx.doi.org/10.1016/j.ajpath.2020.09.005DOI Listing
December 2020

Genome-Wide Wheat 55K SNP-Based Mapping of Stripe Rust Resistance Loci in Wheat Cultivar Shaannong 33 and Their Alleles Frequencies in Current Chinese Wheat Cultivars and Breeding Lines.

Plant Dis 2021 Apr 23;105(4):1048-1056. Epub 2021 Feb 23.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China.

Wheat cultivar Shaannong 33 (SN33) has remained highly resistant to stripe rust in the field since its release in 2009. To unravel the genetic architecture of stripe rust resistance, seedlings of 161 recombinant inbred lines (RILs) from the cross Avocet S × SN33 were evaluated with two isolates (PST-Lab.1 and PST-Lab.2) of the stripe rust pathogen ( f. sp. ) in the greenhouse, and the RILs were evaluated in naturally or artificially inoculated field sites during two cropping seasons. The RILs and parents were genotyped with the wheat 55K single-nucleotide polymorphism array. Three genomic regions conferring seedling resistance were mapped on chromosomes 1DS, 2AS, and 3DS, and four consistent quantitative trait loci (QTL) for adult-plant resistance (APR) were detected on 1BL, 2AS, 3DL, and 6BS. The 2AS locus conferring all-stage resistance was identified as the resistant gene located on 2NS translocation. The QTL identified on 1BL and 6BS likely correspond to and , respectively. An APR QTL on 3DL explaining 5.8 to 12.2% of the phenotypic variation is likely to be new. Molecular marker detection assays with the 2NS segment (), , , and on a panel of 420 current Chinese wheat cultivars and breeding lines indicated that these genes were present in 11.4, 7.6, 14.8, and 7.4% of entries, respectively. The interactions among these genes and QTL were additive, suggesting their potential value in enhancing stripe rust resistance breeding materials as observed in the resistant parent. In addition, we also identified two leaf necrosis genes, and ; however, the F plants from cross Avocet S × SN33 survived, indicating that SN33 probably has another allele of which allows seed to be harvested.
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http://dx.doi.org/10.1094/PDIS-07-20-1516-REDOI Listing
April 2021

A comparison of ICD- 11 and DSM-5 criteria for PTSD among a representative sample of Chinese earthquake survivors.

Eur J Psychotraumatol 2020 Jun 4;11(1):1760481. Epub 2020 Jun 4.

Department of Psychology, and Department of Psychiatry, University of Toledo, Toledo, OH, USA.

Background: Striking differences regarding the diagnosis of PTSD exist between the ICD-11 and DSM-5. This study compared the prevalence and comorbidity of PTSD between the ICD-11 and DSM-5.

Methods: An epidemiological sample of 1160 Chinese adult earthquake survivors collected nine and a half years following the Wenchuan earthquake, in Sichuan province. The PTSD Checklist for DSM-5 (PCL-5), the Patient Health Questionnaire (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) were used to measure PTSD, depression, and anxiety symptoms.

Results: The ICD-11 PTSD criteria yielded higher prevalence estimates than the DSM-5 criteria. There were no significant differences in PTSD's comorbidity with major depressive disorder (MDD) or generalized anxiety disorder (GAD) between the ICD-11 and DSM-5 criteria.

Conclusions: Results found that the ICD-11 and DSM-5 performed differently in assessing PTSD prevalence, but showed similar co-occurrence with MDD and GAD. This study adds to knowledge about the similarities and differences of using different PTSD criteria and carries implications for clinical and research utilization of the two widely used PTSD diagnostic criteria.
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http://dx.doi.org/10.1080/20008198.2020.1760481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448929PMC
June 2020

Impact of the COVID-19 pandemic on mental health in the general Chinese population: Changes, predictors and psychosocial correlates.

Psychiatry Res 2020 11 18;293:113396. Epub 2020 Aug 18.

Center for Brain Disorder and Cognitive Science, Shenzhen University, Shenzhen, 518060 China; Shenzhen Institute of Neuroscience, Shenzhen 518057, China. Electronic address:

The current COVID-19 pandemic is not only a threat to physical health, but also brings a burden to mental health in the general Chinese population. However, the temporal change of mental health status due to pandemic-related stress in relation to protective and risk factors to hostility is less known. This study was implemented at two timepoints, i.e., during the peak and the remission of the COVID-19 pandemic. 3233 Chinese individuals participated in the first wave, and among them 1390 participants were followed in a second wave. The result showed that fear significantly decreased over time, while depression level significantly increased during the second wave compared to the first wave of the survey. Younger age, lower-income, increased level of perceived stress, and current quarantine experience were significant predictors of depression escalation. Younger people and individuals who had a higher initial stress response tended to show more hostility. Furthermore, the use of negative coping strategy plays a potential intermediating role in the stress-related increase in hostility, while social support acts as a buffer in hostility in the general population under high stress. As the whole world is facing the same pandemic, this research provides several implications for public mental health intervention.
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http://dx.doi.org/10.1016/j.psychres.2020.113396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431364PMC
November 2020

Vehicular non-exhaust particulate emissions in Chinese megacities: Source profiles, real-world emission factors, and inventories.

Environ Pollut 2020 Nov 12;266(Pt 2):115268. Epub 2020 Aug 12.

Tianjin Key Laboratory of Urban Transport Emission Research& State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China. Electronic address:

Vehicular non-exhaust emissions account for a significant share of atmospheric particulate matter (PM) pollution, but few studies have successfully quantified the contribution of non-exhaust emissions via real-world measurements. Here, we conduct a comprehensive study combining tunnel measurements, laboratory dynamometer and resuspension experiments, and chemical mass balance modeling to obtain source profiles, real-world emission factors (EFs), and inventories of vehicular non-exhaust PM emissions in Chinese megacities. The average vehicular PM and PM EFs measured in the four tunnels in four megacities (i.e., Beijing, Tianjin, Zhengzhou, and Qingdao) range from 8.8 to 16.0 mg km veh and from 37.4 to 63.9 mg km veh, respectively. A two-step source apportionment is performed with the information of key tracers and localized profiles of each exhaust and non-exhaust source. Results show that the reconstructed PM emissions embody 51-64% soil and cement dust, 26-40% tailpipe exhaust, 7-9% tire wear, and 1-3% brake wear, while PM emissions are mainly composed of 59-80% tailpipe exhaust, 11-31% soil and cement dust, 4-10% tire wear, and 1-5% brake wear. Fleet composition, road gradient, and pavement roughness are essential factors in determining on-road non-exhaust emissions. Based on the EFs and the results of source apportionment, we estimate that the road dust, tire wear, and brake wear emit 8.1, 2.5, and 0.8 Gg year PM in China, respectively. Our study highlights the importance of non-exhaust emissions in China, which is essential to assess their impacts on air quality, human health, and climate and formulating effective controlling measures.
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http://dx.doi.org/10.1016/j.envpol.2020.115268DOI Listing
November 2020

Ultrathin Glass-Based Flexible, Transparent, and Ultrasensitive Surface Acoustic Wave Humidity Sensor with ZnO Nanowires and Graphene Quantum Dots.

ACS Appl Mater Interfaces 2020 Sep 19;12(35):39817-39825. Epub 2020 Aug 19.

Engineering Research Center of Automotive Electrics and Control Technology, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, P. R. China.

Flexible electronic devices are normally based on organic polymer substrate. In this work, an ultrathin glass-based flexible, transparent, and ultrasensitive ZnO/glass surface acoustic wave (SAW) humidity sensor is developed using a composite sensing layer of ZnO nanowires (NWs) and graphene quantum dots (GQDs). It shows much larger effective electromechanical coupling coefficients and signal amplitudes, compared to those of flexible polymer-based SAW devices reported in the literature. Attributed to large specific surface areas of ZnO NWs, large numbers of hydrophilic functional groups of GQDs, as well as the formation of p-n heterojunctions between GQDs and ZnO NWs, the developed ZnO/glass flexible SAW sensor shows an ultrahigh humidity sensitivity of 40.16 kHz/% RH, along with its excellent stability and repeatability. This flexible and transparent SAW sensor has demonstrated insignificant deterioration of humidity sensing performance, when it is bent on a curved surface with a bending angle of 30°, revealing its potential applications for sensing on curved and complex surfaces. The humidity sensing and human breathing detection have further been demonstrated for wearable electronic applications using ultrathin glass-based devices with completely inorganic materials.
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http://dx.doi.org/10.1021/acsami.0c09962DOI Listing
September 2020

Supply of I-131 in a 2 MW molten salt reactor with different production methods.

Appl Radiat Isot 2020 Dec 4;166:109350. Epub 2020 Aug 4.

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; CAS Innovative Academies in TMSR Energy System, Chinese Academy of Sciences, Shanghai, 201800, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Four I-131 production methods including irradiated TeO target and uranium target in the irradiation channel, batch-wise extracted iodine from the fuel salt, and online extracted solid tellurium through the by-pass loop system have been assessed in a 2 MW molten salt reactor. The latter method can produce a large annual yield of I-131 (about 155,000 Ci). The radioactivity shielding demand of the latter method is much smaller than the other I-131 production methods under the identical annual yield of I-131.
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http://dx.doi.org/10.1016/j.apradiso.2020.109350DOI Listing
December 2020