Publications by authors named "Jiangwei Yao"

32Publications

Host Fatty Acid Utilization by Staphylococcus aureus at the Infection Site.

mBio 2020 05 19;11(3). Epub 2020 May 19.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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May 2020

The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI).

J Biol Chem 2020 05 21;295(22):7635-7652. Epub 2020 Apr 21.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

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May 2020

Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains.

mBio 2020 03 3;11(2). Epub 2020 Mar 3.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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March 2020

A pantothenate kinase-deficient mouse model reveals a gene expression program associated with brain coenzyme a reduction.

Biochim Biophys Acta Mol Basis Dis 2020 05 7;1866(5):165663. Epub 2020 Jan 7.

St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. Electronic address:

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May 2020

Fatty acid activation and utilization by Alistipes finegoldii, a representative Bacteroidetes resident of the human gut microbiome.

Mol Microbiol 2020 04 6;113(4):807-825. Epub 2020 Jan 6.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee.

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April 2020

Characterizing a Murine Model for Astrovirus Using Viral Isolates from Persistently Infected Immunocompromised Mice.

J Virol 2019 07 14;93(13). Epub 2019 Jun 14.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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July 2019

Human pantothenate kinase 4 is a pseudo-pantothenate kinase.

Protein Sci 2019 06 17;28(6):1031-1047. Epub 2019 Apr 17.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, 38105.

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June 2019

Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis.

Front Microbiol 2018 25;9:2291. Epub 2018 Sep 25.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, United States.

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September 2018

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.

Nat Struct Mol Biol 2017 Aug 17;24(8):666-671. Epub 2017 Jul 17.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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August 2017

Exogenous fatty acid metabolism in bacteria.

Biochimie 2017 Oct 28;141:30-39. Epub 2017 Jun 28.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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October 2017

Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes.

Infect Immun 2016 Dec 18;84(12):3597-3607. Epub 2016 Nov 18.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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December 2016

Bacterial fatty acid metabolism in modern antibiotic discovery.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Nov 23;1862(11):1300-1309. Epub 2016 Sep 23.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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November 2017

A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome.

Antimicrob Agents Chemother 2016 07 20;60(7):4264-73. Epub 2016 Jun 20.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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July 2016

Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.

Cold Spring Harb Perspect Med 2016 Mar 1;6(3):a027045. Epub 2016 Mar 1.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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March 2016

Chlamydia trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase.

J Biol Chem 2015 Sep 20;290(36):22163-73. Epub 2015 Jul 20.

From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

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September 2015

Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis.

J Biol Chem 2015 Jul 20;290(31):18874-88. Epub 2015 May 20.

From the Departments of Infectious Diseases and

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July 2015

How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.

J Biol Chem 2015 Mar 3;290(10):5940-6. Epub 2015 Feb 3.

From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

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March 2015

FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

Antimicrob Agents Chemother 2015 Feb 17;59(2):849-58. Epub 2014 Nov 17.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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February 2015

Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.

BMC Microbiol 2013 Nov 16;13:260. Epub 2013 Nov 16.

Department of Infectious Diseases, St, Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis TN 38105, USA.

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November 2013

Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).

J Biol Chem 2013 Dec 4;288(51):36261-71. Epub 2013 Nov 4.

From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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December 2013

Phosphatidic acid synthesis in bacteria.

Biochim Biophys Acta 2013 Mar 30;1831(3):495-502. Epub 2012 Aug 30.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, USA.

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March 2013

Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus.

J Bacteriol 2012 Oct 27;194(19):5294-304. Epub 2012 Jul 27.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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October 2012

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria.

Bioorg Med Chem 2012 Aug 23;20(16):4985-94. Epub 2012 Jun 23.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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August 2012

Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase.

J Am Chem Soc 2009 Nov;131(45):16340-1

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

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November 2009

Kinetic characterization of human phosphopantothenoylcysteine synthetase.

Biochim Biophys Acta 2009 Dec 13;1794(12):1743-50. Epub 2009 Aug 13.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

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December 2009

Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis.

Biochemistry 2009 Mar;48(12):2799-806

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

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March 2009