Jiangwei Yao

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.

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March 2020

Fatty acid activation and utilization by Alistipes finegoldii, a representative Bacteroidetes resident of the human gut microbiome.

Authors:

Christopher D Radka Matthew W Frank Charles O Rock Jiangwei Yao

Mol Microbiol 2020 04 6;113(4):807-825. Epub 2020 Jan 6.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee.

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April 2020

Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus.

Authors:

Paola K Párraga Solórzano Jiangwei Yao Charles O Rock Thomas E Kehl-Fie

mBio 2019 08 6;10(4). Epub 2019 Aug 6.

Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

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August 2019

Characterizing a Murine Model for Astrovirus Using Viral Isolates from Persistently Infected Immunocompromised Mice.

Authors:

Valerie Cortez Bridgett Sharp Jiangwei Yao Brandi Livingston Peter Vogel Stacey Schultz-Cherry

J Virol 2019 07 14;93(13). Epub 2019 Jun 14.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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July 2019

Human pantothenate kinase 4 is a pseudo-pantothenate kinase.

Authors:

Jiangwei Yao Chitra Subramanian Charles O Rock Suzanne Jackowski

Protein Sci 2019 06 17;28(6):1031-1047. Epub 2019 Apr 17.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, 38105.

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June 2019

Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis.

Authors:

Jiangwei Yao Charles O Rock

Front Microbiol 2018 25;9:2291. Epub 2018 Sep 25.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, United States.

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September 2018

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.

Authors:

Rosanna M Robertson Jiangwei Yao Stefan Gajewski Gyanendra Kumar Erik W Martin Charles O Rock Stephen W White

Nat Struct Mol Biol 2017 Aug 17;24(8):666-671. Epub 2017 Jul 17.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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August 2017

Exogenous fatty acid metabolism in bacteria.

Authors:

Jiangwei Yao Charles O Rock

Biochimie 2017 Oct 28;141:30-39. Epub 2017 Jun 28.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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October 2017

Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes.

Authors:

Jiangwei Yao Megan E Ericson Matthew W Frank Charles O Rock

Infect Immun 2016 Dec 18;84(12):3597-3607. Epub 2016 Nov 18.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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December 2016

Bacterial fatty acid metabolism in modern antibiotic discovery.

Authors:

Jiangwei Yao Charles O Rock

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Nov 23;1862(11):1300-1309. Epub 2016 Sep 23.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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November 2017

Allosteric Regulation of Mammalian Pantothenate Kinase.

Authors:

Chitra Subramanian Mi-Kyung Yun Jiangwei Yao Lalit Kumar Sharma Richard E Lee Stephen W White Suzanne Jackowski Charles O Rock

J Biol Chem 2016 Oct 23;291(42):22302-22314. Epub 2016 Aug 23.

From the Departments of Infectious Diseases,

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October 2016

A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome.

Authors:

Jiangwei Yao Robert A Carter Grégoire Vuagniaux Maryse Barbier Jason W Rosch Charles O Rock

Antimicrob Agents Chemother 2016 07 20;60(7):4264-73. Epub 2016 Jun 20.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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July 2016

Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.

Authors:

Jiangwei Yao Charles O Rock

Cold Spring Harb Perspect Med 2016 Mar 1;6(3):a027045. Epub 2016 Mar 1.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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March 2016

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria.

Authors:

Jiangwei Yao David F Bruhn Matthew W Frank Richard E Lee Charles O Rock

J Biol Chem 2016 Jan 13;291(1):171-81. Epub 2015 Nov 13.

From the Departments of Infectious Diseases and

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January 2016

Chlamydia trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase.

Authors:

Jiangwei Yao V Joshua Dodson Matthew W Frank Charles O Rock

J Biol Chem 2015 Sep 20;290(36):22163-73. Epub 2015 Jul 20.

From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

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September 2015

Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis.

Authors:

Jiangwei Yao Philip T Cherian Matthew W Frank Charles O Rock

J Biol Chem 2015 Jul 20;290(31):18874-88. Epub 2015 May 20.

From the Departments of Infectious Diseases and

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July 2015

How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.

Authors:

Jiangwei Yao Charles O Rock

J Biol Chem 2015 Mar 3;290(10):5940-6. Epub 2015 Feb 3.

From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

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March 2015

FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

Authors:

Joshua B Parsons Jiangwei Yao Matthew W Frank Charles O Rock

Antimicrob Agents Chemother 2015 Feb 17;59(2):849-58. Epub 2014 Nov 17.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

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February 2015

Type II fatty acid synthesis is essential for the replication of Chlamydia trachomatis.

Authors:

Jiangwei Yao Yasser M Abdelrahman Rosanna M Robertson John V Cox Robert J Belland Stephen W White Charles O Rock

J Biol Chem 2014 Aug 23;289(32):22365-76. Epub 2014 Jun 23.

From the Departments of Infectious Diseases and

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August 2014

Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.

Authors:

Joshua B Parsons Jiangwei Yao Pamela Jackson Matthew Frank Charles O Rock

BMC Microbiol 2013 Nov 16;13:260. Epub 2013 Nov 16.

Department of Infectious Diseases, St, Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis TN 38105, USA.

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November 2013

Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).

Authors:

Jiangwei Yao John B Maxwell Charles O Rock

J Biol Chem 2013 Dec 4;288(51):36261-71. Epub 2013 Nov 4.

From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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December 2013

Phosphatidic acid synthesis in bacteria.

Authors:

Jiangwei Yao Charles O Rock

Biochim Biophys Acta 2013 Mar 30;1831(3):495-502. Epub 2012 Aug 30.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, USA.

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March 2013

Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus.

Authors:

Joshua B Parsons Jiangwei Yao Matthew W Frank Pamela Jackson Charles O Rock

J Bacteriol 2012 Oct 27;194(19):5294-304. Epub 2012 Jul 27.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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October 2012

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria.

Authors:

Philip T Cherian Jiangwei Yao Roberta Leonardi Marcus M Maddox Vicki A Luna Charles O Rock Richard E Lee

Bioorg Med Chem 2012 Aug 23;20(16):4985-94. Epub 2012 Jun 23.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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August 2012

Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase.

Authors:

James D Patrone Jiangwei Yao Nicole E Scott Garry D Dotson

J Am Chem Soc 2009 Nov;131(45):16340-1

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

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November 2009

Kinetic characterization of human phosphopantothenoylcysteine synthetase.

Authors:

Jiangwei Yao Garry D Dotson

Biochim Biophys Acta 2009 Dec 13;1794(12):1743-50. Epub 2009 Aug 13.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

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December 2009

Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis.

Authors:

Jiangwei Yao James D Patrone Garry D Dotson

Biochemistry 2009 Mar;48(12):2799-806

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

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March 2009

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