Publications by authors named "Jian-Jun Shi"

29 Publications

  • Page 1 of 1

Evaluation of efficacy and safety of PARP inhibitors in breast cancer: A systematic review and meta-analysis.

Breast 2021 May 27;59:44-50. Epub 2021 May 27.

Department of Breast, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China. Electronic address:

Background: Many breast cancer clinical trials with PARPi have been completed or are currently carried out, either by monotherapy or combined with chemotherapy. We aim to assess the efficacy and safety of PARPi in breast cancer patients as compared to chemotherapy.

Methods: A comprehensive literature search of PubMed, EMBASE, CENTRAL, conference meetings and clinical trial registry was performed. The primary outcomes were progression-free survival (PFS), overall survival (OS), overall response rate (ORR). The secondary outcome was safety profile. The comparative effects were measured using hazard ratio (HR) or relative risk (RR) with 95% confidence interval. Subgroup analyses were conducted based on types of intervention and baseline characteristics of patients.

Results: Six RCTs (n = 1953) were included. Two RCTs were recognized as high risk. PARPi was associated with an improved PFS (HR, 0.65; 95% CI, 0.56-0.74), OS (HR, 0.86; 95% CI, 0.73-1.01), and a higher ORR (RR, 1.38; 95% CI, 1.05-1.82). PARPi, however, significantly increased risk of grade 3-4 thrombocytopenia (RR, 1.63; 95% CI, 1.06-2.52). Monotherapy was observed with lower risk of disease progression and higher ORR rate than combination therapy, 0.56 to 0.65 and 2.21 to 1.05, respectively. For patients without prior platinum treatment, PARPi significantly improved PFS (HR, 0.64; 95% CI, 0.52-0.79).

Conclusions: PARPi was observed with a significantly improved efficacy in aspects of PFS and ORR, but also higher risk of grade 3-4 thrombocytopenia as compared to chemotherapy. PARPi was a better choice for patients who had not received previous platinum treatment.
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http://dx.doi.org/10.1016/j.breast.2021.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215282PMC
May 2021

Electron Information in Single- and Dual-Frequency Capacitive Discharges at Atmospheric Pressure.

Sci Rep 2018 May 14;8(1):7516. Epub 2018 May 14.

College of Science, Donghua University, Shanghai, 201620, China.

Determining the electron properties of weakly ionized gases, particularly in a high electron-neutral collisional condition, is a nontrivial task; thus, the mechanisms underlying the electron characteristics and electron heating structure in radio-frequency (rf) collisional discharges remain unclear. Here, we report the electrical characteristics and electron information in single-frequency (4.52 MHz and 13.56 MHz) and dual-frequency (a combination of 4.52 MHz and 13.56 MHz) capacitive discharges within the abnormal α-mode regime at atmospheric pressure. A continuum radiation-based electron diagnostic method is employed to estimate the electron density (n) and temperature (T). Our experimental observations reveal that time-averaged n (7.7-14 × 10 cm) and T (1.75-2.5 eV) can be independently controlled in dual-frequency discharge, whereas such control is nontrivial in single-frequency discharge, which shows a linear increase in n and little to no change in T with increases in the rf input power. Furthermore, the two-dimensional spatiotemporal evolution of neutral bremsstrahlung and associated electron heating structures is demonstrated. These results reveal that a symmetric structure in electron heating becomes asymmetric (via a local suppression of electron temperature) as two-frequency power is simultaneously introduced.
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http://dx.doi.org/10.1038/s41598-018-25892-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951922PMC
May 2018

Ultrasensitive photoelectrochemical aptasensor for lead ion detection based on sensitization effect of CdTe QDs on MoS-CdS:Mn nanocomposites by the formation of G-quadruplex structure.

Talanta 2018 Jun 19;183:237-244. Epub 2018 Mar 19.

School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.

An ultrasensitive photoelectrochemical (PEC) aptasensor for lead ion (Pb) detection was fabricated based on MoS-CdS:Mn nanocomposites and sensitization effect of CdTe quantum dots (QDs). MoS-CdS:Mn modified electrode was used as the PEC matrix for the immobilization of probe DNA (pDNA) labeled with CdTe QDs. Target DNA (tDNA) were hybridized with pDNA to made the QDs locate away from the electrode surface by the rod-like double helix. The detection of Pb was based on the conformational change of the pDNA to G-quadruplex structure in the presence of Pb, which made the labeled QDs move close to the electrode surface, leading to the generation of sensitization effect and evident increase of the photocurrent intensity. The linear range was 50 fM to 100 nM with a detection limit of 16.7 fM. The recoveries of the determination of Pb in real samples were in the range of 102.5-108.0%. This proposed PEC aptasensor provides a new sensing strategy for various heavy metal ions at ultralow levels.
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http://dx.doi.org/10.1016/j.talanta.2018.02.087DOI Listing
June 2018

Visible-light mediated directed perfluoroalkylation of hydrazones.

Org Biomol Chem 2017 Jul;15(28):6014-6023

School of Chemical Engineering, Anhui University of Science and Technology, Huainan, P. R. China.

Perfluoroalkylation of N-alkylhydrazones has been achieved via visible light mediated photoredox reactions between the hydrazone and perfluoroalkyl iodide (RI). This protocol provides a convenient and efficient access to a series of perfluoroalkylated aromatic aldehyde hydrazones which tolerates a wide range of functional groups on the aromatic ring, and allows the use different types of primary and secondary perfluoroalkyl iodides with up to eight carbon atoms. Furthermore, aliphatic aldehyde hydrazones and N-monosubstituted hydrazones which are unreactive in previously reported hydrazone perfluoroalkylation reactions now take part in the reaction under our reaction conditions to give a satisfactory yield of products. Stern-Volmer quenching studies and spin-trapping experiments indicated that these reactions proceed by free radical addition of the R radical to the azomethine atom followed by one electron oxidation of the hydrazyl radical and deprotonation of the diazenium cation.
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http://dx.doi.org/10.1039/c7ob01144jDOI Listing
July 2017

Highly Sensitive and Selective Photoelectrochemical Biosensor for Hg(2+) Detection Based on Dual Signal Amplification by Exciton Energy Transfer Coupled with Sensitization Effect.

Anal Chem 2015 Dec 4;87(24):12340-7. Epub 2015 Dec 4.

State Key Laboratory of Analytical Chemistry for Life Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, People's Republic of China.

A highly sensitive and selective photoelectrochemical (PEC) biosensor for Hg(2+) detection was developed on the basis of the synergistic effect of exciton energy transfer (EET) between CdS quantum dots (QDs) and Au nanoparticles (NPs) coupled with sensitization of rhodamine 123 (Rh123) for signal amplification. First, the TiO2/CdS hybrid structure obtained by depositing CdS QDs on TiO2 film was employed as a matrix for immobilizing probe DNA (pDNA). Next, Rh123 was introduced into the pDNA terminal, and then Au NP labeled target DNA (Au-tDNA) was hybridized with pDNA to form a rod-like double helix structure. The detection of Hg(2+) was based on a conformational change of the pDNA after incubating with Hg(2+). In the absence of Hg(2+), Rh123 was located away from the electrode surface due to the DNA hybridization, leading to inhibition of the sensitization effect, and meanwhile, the occurrence of EET between CdS QDs and Au NPs resulted in a photocurrent decrease. However, after incubating with Hg(2+), the rod-like double helix was disrupted, and the energy transfer was broken. In this case, the photocurrent recovered, and meanwhile, the folded pDNA made the labeled Rh123 move closer to the electrode surface, leading to the formation of the sensitization structure, which evidently increased the photocurrent intensity. The sensitivity of the biosensor for Hg(2+) detection was greatly enhanced for the dual signal amplification strategy. The linear range was 10 fM to 200 nM, with a detection limit of 3.3 fM. This biosensor provides a promising new platform for detecting various heavy metal ions at ultralow levels.
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http://dx.doi.org/10.1021/acs.analchem.5b03721DOI Listing
December 2015

Electron transfer mediated electrochemical biosensor for microRNAs detection based on metal ion functionalized titanium phosphate nanospheres at attomole level.

ACS Appl Mater Interfaces 2015 Feb 21;7(4):2979-85. Epub 2015 Jan 21.

State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, P. R. China.

MicroRNAs (miRNAs) have emerged as new candidates as diagnostic and prognostic biomarkers for the detection of a wide variety of cancers; thus, sensitive and selective detection of microRNAs is significant for early-phase cancer diagnosis and disease prevention. A novel and simple electrochemical miRNA biosensor was developed using Cd(2+)-modified titanium phosphate nanoparticles as signal unit, two DNA as capture probes, and Ru(NH3)6(3+) as electron transfer mediator. Large quantities of cadmium ions were mounted in titanium phosphate spheres to output the electrochemical signal. Because of the presence of Ru(NH3)6(3+) molecules that interacted with DNA base-pairs as electron wire, the electrochemical signal significantly increased more than 5 times. This approach achieved a wide dynamic linear range from 1.0 aM to 10.0 pM with an ultralow limit detection of 0.76 aM, exerting a substantial enhancement in sensitivity. Moreover, the proposed biosensor was sufficiently selective to discriminate the target miRNAs from homologous miRNAs and could be used for rapid and direct analysis of miRNAs in human serum. Therefore, this strategy provides a new and ultrasensitive platform for miRNA expression profiling in biomedical research and clinical diagnosis.
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http://dx.doi.org/10.1021/am508690xDOI Listing
February 2015

Bimetallic Pd-Pt supported graphene promoted enzymatic redox cycling for ultrasensitive electrochemical quantification of microRNA from cell lysates.

Analyst 2014 Aug;139(16):3860-5

State Key Lab of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P.R.China.

The expression of microRNAs (miRNAs) is related to some cancer diseases. Recently, miRNAs have emerged as new candidate diagnostic and prognostic biomarkers for detecting a wide variety of cancers. Due to low levels, short sequences and high sequence homology among family members, the quantitative miRNA analysis is still a challenge. A novel electrochemical biosensor with triple signal amplification for the ultrasensitive detection of miRNA was developed based on phosphatase, redox-cycling amplification, a bimetallic Pd-Pt supported graphene functionalized screen-printed gold electrode, and two stem-loop structured DNAs as target capturers. The proposed biosensor is highly sensitive due to the enhanced electrochemical signal of Pd-Pt supported graphene and sufficiently selective to discriminate the target miRNA from homologous miRNAs in the presence of loop-stem structure probes with T4 DNA ligase. Therefore, this strategy provided a new and ultrasensitive platform for amplified detection and subsequent analysis of miRNA in biomedical research and clinical diagnosis.
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http://dx.doi.org/10.1039/c4an00777hDOI Listing
August 2014

A competitive electrochemical immunosensor for the detection of human interleukin-6 based on the electrically heated carbon electrode and silver nanoparticles functionalized labels.

Talanta 2014 May 1;122:135-9. Epub 2014 Feb 1.

State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. Electronic address:

A facile one-step electrochemical reduction method was developed to prepare electrochemically reduced graphene oxide (ERGO) and gold-palladium bimetallic nanoparticles (AuPdNPs) as the platform of immunosensor. A novel competitive electrochemical immunosensor was then proposed by combining the ERGO-AuPdNPs platform with silver nanoparticles (AgNPs) functionalized polystyrene bionanolabel for the sensitive detection of human interleukin-6 (IL-6). An electrically heated carbon electrode (HCPE) was introduced in the detection procedure of the immunosensor, and further improved the sensitivity. The immunosensor exhibited a wide linear response to IL-6 ranging from 0.1 to 100000 pg mL(-1) with a detection limit of 0.059 pg mL(-1). The proposed method showed good precision, broad linear range, acceptable stability and high reproducibility, and could be used for the detection of IL-6 in real samples, which possessed promising application in clinical research.
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http://dx.doi.org/10.1016/j.talanta.2014.01.016DOI Listing
May 2014

[Establishment and application of imported falciparum malaria control system in Yangzhou City].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2013 Oct;25(5):524-7, 532

Yangzhou Municipal Bureau of Health, Jiangsu Province, China.

To aim at the characteristics of epidemic situation that the imported falciparum malaria cases increased year by year in Yangzhou City, an imported falciparum malaria control system was established. This control system was based on enhancing the management of returned labor service export persons from falciparum malaria endemic areas, the active medical remind service, the diagnostic capability and health education, and the cooperation of medical personnel and patients, and also avoiding diagnosis delay and misdiagnosis and promoting the treatment in time so as to decrease the serious patients and prevent them from death. After the application of the control system, there were 164 imported falciparum malaria cases from the returned persons of labor service export. The time from the attack of the disease to the diagnosis confirmed decreased from 6.8 days before the application of the system to 2.7 days after the application, and the rate of serious patients was 1.8% and there were no death cases.
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October 2013

Ultrasensitive multi-analyte electrochemical immunoassay based on GNR-modified heated screen-printed carbon electrodes and [email protected] labels for rapid detection of MMP-9 and IL-6.

Biosens Bioelectron 2014 May 27;55:51-6. Epub 2013 Nov 27.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. Electronic address:

An ultrasensitive electrochemical immunoassay was developed for rapid detection of interleukin-6 (IL-6) and matrix metallopeptidase-9 (MMP-9); the method utilized [email protected] nanocomposites based on graphene nanoribbon (GNR)-modified heated screen-printed carbon electrode (HSPCE). Because of the good hydrophilicity and low toxicity, GNRs were used to immobilize antibodies (Ab) and amplify the electrochemical signal. [email protected] was used to label antibodies and generate a strong electrochemical signal in acetic buffer. A sandwich strategy was adopted to achieve simultaneous detection of MMP-9 and IL-6 based on HSPCE without cross-talk between adjacent electrodes in the range of 10(-5) to 10(3) ng mL(-1) with detection limits of 5 fg mL(-1) and 0.1 pg mL(-1) (S/N=3), respectively. The proposed method showed wide detection range, low detection limit, acceptable stability and good reproducibility. Satisfactory results were also obtained in the practical samples, thus showing this is a promising technique for simultaneous clinical detection of biocomponent proteins.
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http://dx.doi.org/10.1016/j.bios.2013.11.056DOI Listing
May 2014

Fabrication of a boron nitride-gold nanocluster composite and its versatile application for immunoassays.

Chem Commun (Camb) 2013 Nov;49(91):10757-9

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

A multifunctional boron nitride-gold nanocluster composite was fabricated using poly-diallyldimethylammonium chloride as a stabilizer and a linker. The as-fabricated composite could be used as a fluorescent or an electrochemical label for immunosensing in the sensitive detection of interleukin-6.
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http://dx.doi.org/10.1039/c3cc45759aDOI Listing
November 2013

Fabrication of graphene quantum dots and hexagonal boron nitride nanocomposites for fluorescent cell imaging.

J Biomed Nanotechnol 2013 Oct;9(10):1679-85

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

Graphene quantum dots (GQDs) with green fluorescence were incorporated onto hexagonal boron nitride sheets (HBN) through electrostatic interaction by using poly(diallyldimethylammonium) (PDDA) as the bridge to fabricate the novel nanocomposites (HBN-GQDs). The HBN-GQDs nanocomposites exhibited strong green fluorescent property, high stability, water solubility, very low cytotoxicity on Hela cells. These properties make the HBN-GQDs nanocomposites as good candidate materials for biological applications. The results for the imaging of live cells indicated that the cell-penetrating HBN-GQDs could be a promising nanoprobe for intracellular imaging and therapeutic applications.
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http://dx.doi.org/10.1166/jbn.2013.1663DOI Listing
October 2013

[Maxillary first molar with two palatal canals: a case report].

Authors:
Jian-jun Shi

Shanghai Kou Qiang Yi Xue 2013 Jun;22(3):358-60

Department of Operative Dentistry and Endodontics, Chengde Stomatological Hospital, Chengde, Hebei Province, China.

Maxillary first molar with two palatal canals is rare. Clinicians should be aware of the normal anatomy of root canal system and vigilant about the possible existence of canal variation. A patient with acute episode of chronic pulpitis of 26, as presented by the case report, was examined to have four canals, which were the mesial buccal canal, the distal buccal canal, the mesial palatal canal and the distal palatal canal. When suspecting the existence of canal variation, clinicians should carefully explore the pulpal floor, further by changing the X-ray projection angle to confirm the existence of variation and prevent the missed canals, all of which are necessary for a successful root canal therapy.
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June 2013

Sonoelectrochemical synthesis of water-soluble CdTe quantum dots.

Ultrason Sonochem 2014 Mar 15;21(2):493-8. Epub 2013 Jun 15.

School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

A facile and fast one-pot method has been developed for the synthesis of CdTe quantum dots (QDs) in aqueous phase by a sonoelectrochemical route without the protection of N2. The morphology, structure and composition of the as-prepared products were investigated by high resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD) and energy dispersive X-ray spectrometer (EDS). The influences of current intensity, current pulse width, and reaction temperature on the photoluminescence (PL) and quantum yield (QY) of the products were studied. The experimental results showed that the water-soluble CdTe QDs with high PL qualities can be conveniently synthesized without precursor preparation and N2 protection, and the PL emission wavelength and QY can be effectively controlled by adjusting some parameters. This method can be expected to prepare other QDs as promising building blocks in solar cell, photocatalysis and sensors.
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http://dx.doi.org/10.1016/j.ultsonch.2013.06.003DOI Listing
March 2014

The effects of biotic and abiotic factors on the spatial heterogeneity of alpine grassland vegetation at a small scale on the Qinghai-Tibet Plateau (QTP), China.

Environ Monit Assess 2013 Oct 9;185(10):8051-64. Epub 2013 Apr 9.

State Key Laboratory of Water Environment Simulation, Environmental School of Beijing Normal University, Beijing, 100875, China.

Understanding the complex effects of biotic and abiotic factors on the composition of vegetation is very important for developing and implementing strategies for promoting sustainable grassland development. The vegetation-disturbance-environment relationship was examined in degraded alpine grasslands in the headwater areas of three rivers on the Qinghai-Tibet Plateau in this study. The investigated hypotheses were that (1) the heterogeneity of the vegetation of the alpine grassland is due to a combination of biotic and abiotic factors and that (2) at a small scale, biotic factors are more important for the distribution of alpine vegetation. On this basis, four transects were set along altitudinal gradients from 3,770 to 3,890 m on a sunny slope, and four parallel transects were set along altitudinal gradients on a shady slope in alpine grasslands in Guoluo Prefecture of Qinghai Province, China. It was found that biological disturbances were the major forces driving the spatial heterogeneity of the alpine grassland vegetation and abiotic factors were of secondary importance. Heavy grazing and intensive rat activity resulted in increases in unpalatable and poisonous weeds and decreased fine forages in the form of sedges, forbs, and grasses in the vegetation composition. Habitat degradation associated with biological disturbances significantly affected the spatial variation of the alpine grassland vegetation, i.e., more pioneer plants of poisonous or unpalatable weed species, such as Ligularia virgaurea and Euphorbia fischeriana, were found in bare patches. Environmental/abiotic factors were less important than biological disturbances in affecting the spatial distribution of the alpine grassland vegetation at a small scale. It was concluded that rat control and light grazing should be applied first in implementing restoration strategies. The primary vegetation in lightly grazed and less rat-damaged sites should be regarded as a reference for devising vegetation restoration measures in alpine pastoral regions.
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http://dx.doi.org/10.1007/s10661-013-3154-yDOI Listing
October 2013

Seed rain and its relationship with above-ground vegetation of degraded Kobresia meadows.

J Plant Res 2013 Jan 12;126(1):63-72. Epub 2012 Jun 12.

International Centre for Tibetan Plateau Ecosystem Management, State Key Laboratory of Grassland Farming Systems, College of Pastoral Agriculture Science and Technology, Lanzhou University, No. 768, Jiayuguan West Road, Lanzhou, Gansu 730020, China.

Seed rain is a crucial element in vegetation regeneration, but has been rarely studied in high altitude regions, particularly degraded Kobresia meadow. Weed infestation is a distinctive feature of pasture degradation in Kobresia meadows on the Tibetan plateau, the ecological mechanism of which is closely related with vegetation's seed rain. In this paper we assess the effect of vegetation degradation on seed rain and consider its implication for restoration of degraded Kobresia meadows in the headwater area of Yellow river, through analysis of seed species composition, number of seeds landing per m(2) of soil surface, and their relationship with above ground vegetation. Vegetation degradation had an impact on the species composition and numbers of seeds in seed rain and their relationship with above-ground vegetation. Within the un-degraded meadow, which provided a closed vegetation cover, 35 % of the seed rain was of sedge and gramineae species. However, within the degraded meadows, as the extent of degradation increased, so the total number of seeds m(-2) increased, with those derived from sedge and gramineae species forming a declining proportion of the total. Degradation of Kobresia meadow on the Tibetan plateau is exacerbated by the seed input of weed species (such as Oxytropis ochrocephala, Carum carvi, Aconitum pendulum, Pedicularis kansuensis in this study). Therefore, a major priority for the restoration of such degraded meadows should be the elimination of these weeds from the above ground vegetation by human intervention.
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http://dx.doi.org/10.1007/s10265-012-0498-2DOI Listing
January 2013

Sonoelectrochemical synthesis and assembly of bismuth-antimony alloy: from nanocrystals to nanoflakes.

Ultrason Sonochem 2012 Sep 12;19(5):1039-43. Epub 2012 Mar 12.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.

Bismuth-based nanostructures have attracted growing interest because of their promising thermoelectric properties and applications in optics and electronics. Pulsed sonoelectrochemical technique was selected to fabricate bismuth-antimony (BiSb) flake-like alloy in ethylene glycol aqueous solution. The formation mechanism for the BiSb alloy was discussed. Ultrasonic played an important role in regenerating electrode and promoting the formation of BiSb nanoflakes. Citrate and polyvinylpyrrolidone (PVP) were introduced as mixed controlling agents during the nucleation and growth process.
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http://dx.doi.org/10.1016/j.ultsonch.2012.03.001DOI Listing
September 2012

[Uptake 14CO2 from air and accumulation of 14C in hornwort].

Authors:
Jian-Jun Shi

Huan Jing Ke Xue 2011 Feb;32(2):479-82

Institute of Science, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Uptake 14CO2 from air and accumulation of 14C in the hornwort were studied by using the isotope-tracer techniques in order to get a better understanding of the environmental behavior of 14CO2. And the possibility of hornwort used as the indicator plant in the supervisor of 14CO2 air pollution was discussed. The results show that the hornwort could uptake 14CO2 from the air by some way and formed an accumulating trend. The main way was that the hornwort absorbed free 14CO2 and H 14CO3- from the water through photosynthesis. During the introducing 14CO2, the increasing rate of 14C specific activity in dry hornwort and fresh hornwort were between 91.9-95.6 Bq/(g x d) and 6.1-6.3 Bq/(g x d), respectively, which was roughly equal to the increasing rate in the wheat. The results indicate that the hornwort had strong ability of absorbing 14CO2 indirectly through water. The hornwort has an certain concentration of 14CO2. And the concentration factor (CF) values rise with the introduction of 14CO2 and decline slowly after it reached the maximum value. Owing to its accumulation of 14CO2, hornwort can be used as the indicator plant in the supervisor of 14CO2 air pollution.
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February 2011

Structure characterization of Ag-Ga/poly(methyl methacrylate) nanoparticles.

J Nanosci Nanotechnol 2010 Aug;10(8):5441-4

Department of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, PR China.

The Ag-Ga/poly(methyl methacrylate) nanoparticles were prepared in-situ by emulsion polymerization method under ultrasonic irradiation without any initiators or metal reductant. HRTEM, EDS and XRD experiments were performed to characterize the nanoparticles. The results indicated that the nanocomposite particles possessed core-shell structure with diameters of 80-200 nm, as well as excellent monodispersity. The phenomenon that the polymer forms the shell via layer-by-layer self-assembly was found. XRD proved the existence of Ag0.72Ga0.28 and the probability of new Ag-Ga alloy because of two unknown diffraction peaks.
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http://dx.doi.org/10.1166/jnn.2010.1934DOI Listing
August 2010

Ionic liquid as extraction agent for detection of volatile phenols in wastewater and its regeneration.

J Sep Sci 2010 May;33(9):1356-9

School of Chemical Engineering, Anhui University of Science and Technology, Huainan, PR China.

Volatile phenols in the wastewater provide a basic parameter of the pollution. Spectrophotometric method based on the reactions of the individual phenols with 4-aminoantipyrine in the presence of an oxidizing agent is the current official analytical method in many countries. In this paper, we propose a method for extracting the resultant colored dye with ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate instead of chloroform. The results revealed excellent extraction efficiency, and the used ionic liquid could be regenerated easily. The method with small volume green reagent could be potentially applied in portable devices for in situ environmental analysis.
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http://dx.doi.org/10.1002/jssc.200900730DOI Listing
May 2010

Effects of fruit extracts on the formation of acrylamide in model reactions and fried potato crisps.

J Agric Food Chem 2010 Jan;58(1):309-12

School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong.

Natural products extracted from plants and fruits have attracted increasing attention for the development of effective inhibitors against the formation of acrylamide during food processing. In this study, six fruit extracts (apple, blueberry, mangosteen, longan, dragon fruit with white flesh, and dragon fruit with red flesh) were compared for their activities against acrylamide formation in chemical models containing equal molar quantities of glucose and asparagine in distilled water (160 degrees C for 30 min). Apple extract demonstrated potent inhibition on acrylamide formation. Blueberry, mangosteen, and longan extracts did not have significant impact, whereas dragon fruit extracts enhanced acrylamide formation. Column chromatography guided by chemical model analysis showed that the proanthocyanidin-rich subfraction played a key role in mediating the inhibitory activity. The inhibitory activity was finally corroborated in fried potato crisps. The present study identified some natural products that might have important applications in the food industry to inhibit acrylamide formation.
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http://dx.doi.org/10.1021/jf902529vDOI Listing
January 2010

[Advances in CT classification and outcomes assesment of calcaneus fractures].

Zhongguo Gu Shang 2008 Mar;21(3):207-10

Department of Orthopaedics, Xi'an Red Cross Hospital, Xi'an 710054, Shaanxi, China.

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March 2008

[Arsenic trioxide resulting in alveolar bone chemical necrosis: report of 2 cases].

Authors:
Jian-Jun Shi

Shanghai Kou Qiang Yi Xue 2008 Jun;17(3):335-6

Department of Operative Dentistry and Endodontics Stomatological Hospital. Chengde 067000, Hebei Province, China.

The most serious complication of arsenic trioxide devitalization of dental pulp is alveolar bone chemical necrosis because of iatrogenic perforation of pulp chamber and arsenic trioxide leakage. Arsenic trioxide is protoplasmic poison.When it contacts periodontal tissues, alveolar bone degeneration, necrosis and loss of bone will occur. When the dental of pulp chamber is open, the operator must pay attention to the length and orientation of the bur, with guidance of the dental X-ray film to avoid pulp chamber perforation.
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June 2008

Quality of embryonic bodies and seeding density effects on neural differentiation of mouse embryonic stem cells.

Cell Biol Int 2008 Sep 9;32(9):1169-75. Epub 2008 May 9.

Center for Developmental Biology, Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kong Jian Road, Shanghai 200092, PR China.

Mouse embryonic stem (ES) cells can be differentiated into neural lineage cells, but the differentiation efficiency remains low. This study revealed two important factors that influence the neural differentiation efficiency of mouse ES cells: the first is the quality of embryonic bodies (EBs); good quality of EBs consistently originated from a suspension culture of 1x10(5) ES cells/ml serum-free chemically defined neural inducing medium and they exhibited a smooth round shape, with a dark central region surrounded by a light band. Such EBs are capable of attaining high neural differentiation efficiency. However, poor quality EBs originated from a suspension culture of 1x10(6) ES cells/ml serum-free chemically defined neural inducing medium and exhibited an irregular shape or adhered to the bottom of the dish; they displayed low neural differentiation efficiency. The second factor is the seeding density of EBs: a low seeding density (5 EBs/cm2) induced cells to differentiate into a more caudalized subtypes compared to the cells obtained from high seeding density (20 EBs/cm2). These findings provided fresh insight into the neural induction of mouse ES cells.
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http://dx.doi.org/10.1016/j.cellbi.2008.04.025DOI Listing
September 2008

[Characteristics of artificial grassland plant communities with different establishment duration and their relationships with soil properties in the source region of three rivers in China].

Ying Yong Sheng Tai Xue Bao 2007 Nov;18(11):2426-31

Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China.

This paper studied the biomass, species composition, and diversity index of artificial grassland plant communities with different establishment duration in the source region of the Three Rivers, and examined the relationships of soil physical and chemical properties with the changes of the plant community biomass and species diversity. The results showed that the species composition, functional group composition, and quantitative characters of the plant communities varied greatly. Soil moisture content increased with increasing species diversity, while soil bulk density was in adverse. Soil microbial biomass carbon significantly positively correlated with soil moisture and organic matter contents, but negatively correlated with soil bulk density. Soil organic carbon content had a "V" type change, which was consistent with the change pattern of soil moisture content, and decreased with increasing soil bulk density. Plant community biomass had significant positive correlations with the contents of soil nutrients and moisture, and the increase of the above- and below-ground biomass of plant communities promoted the increase of soil nutrient contents.
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November 2007

[Uptake 14CO2 from air and accumulation of 14C in Chinese cabbage].

Huan Jing Ke Xue 2007 Aug;28(8):1806-9

Institute of Science, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Uptake 14CO2 from air and accumulation of 14C in the Chinese cabbage were studied by using the isotope-tracer techniques in order to get a better understanding of the environmental behavior of 14CO. The results show that the 14CO2, which was uptaken from the air by the leaf photosynthesis, would be sent to the other part of the Chinese cabbage and form a accumulating trend. The specific activity of 14C in every tissue increases linearly with time, and the increasing rate is in the range of 95.3 - 270.2 Bq/(g x d). The order of rate in tissues is as below: cabbage heart > leaf blade > leaf stalk > basal plate > root. The Chinese cabbage has an intensive concentration of 14CO2, and the concentration factor values increase rapidly with time. The concentration factor values in the cabbage heart reach the highest level (156.4 in 48 days) and following with the leaf blade (135.6 in 48 days). The specific activity in each part of the Chinese cabbage also increases with the introduction times of the 14CO2. Regression analysis has proved that the specific activity (C) of every part is positively correlated to the introducing times (N). Owing to its high accumulation of 14CO2, Chinese cabbage can be used as the indicator plant in the supervisor of 14CO2 air pollution.
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August 2007

[Uptake HTO from seawater by seashell and formative dynamics of bound tritium in seashell].

Huan Jing Ke Xue 2005 Jul;26(4):177-80

Institute of Science, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Uptake HTO from seawater by five kinds seashell and formative dynamics of bound tritium in organ of seashell are studied by using the isotope-tracer techniques in order to get a better understanding of the marine environmental behavior of HTO. The results show that the tritium in seashell exists in free water tritium and bound tritium form. The free water tritium is main form; its content observed was more than 97.4% of total tritium. The bound tritium content was very lower, only being 0.4% - 2.6% in total tritium. The speed of HTO untaken by seashell is very rapid, specific activity of HTO in three kinds seashell had reached their maximum only 2 h after treatment. The bound tritium in seashell increases slowly with time. The results of analysis of concentration factor (CF) values indicate that HTO would not concentrate in the seashell.
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July 2005

Dynamics of transfer and distribution of 95Zr in the broadbean-soil ecosystem.

J Environ Radioact 2005 ;80(2):217-23

Key Laboratory of Nuclear Agricultural Science of the Ministry of Agriculture, Institute of Nuclear Agricultural Science, Zhejiang University, Hangzhou 310029, China.

The transfer and distribution of (95)Zr in a simulated broadbean-soil system was studied by using isotope-tracer techniques. The results showed that the (95)Zr was mainly concentrated in the haulm, pod and root, and the activity concentration of (95)Zr in these tissues reached the maximum in the initial stage then decreased continuously. The activity concentration of (95)Zr in edible part-bean was relatively lower, which was just near to the detection limit. The (95)Zr in soil was mainly (97%) deposited in surface layer soil (0-6 cm), indicating that the (95)Zr absorbed by surface soil could not be moved downwards easily because of the strong adsorption. The dynamics of (95)Zr concentrations in broadbean and soil were also confirmed by application of nonlinear regression method.
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http://dx.doi.org/10.1016/j.jenvrad.2004.09.001DOI Listing
June 2005

[Apoptosis in mammalian reproduction].

Sheng Li Ke Xue Jin Zhan 2002 Jan;33(1):82-4

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January 2002
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