Publications by authors named "Jian-Gang Wu"

2 Publications

  • Page 1 of 1

Epidemiology and Clinical Characteristics of Henoch-Schönlein Purpura Associated with Epstein-Barr Virus Infection.

Mediterr J Hematol Infect Dis 2021 1;13(1):e2021064. Epub 2021 Nov 1.

Medical department, The first people's Hospital of Guangshui, China.

Background: Henoch-Schönlein purpura (HSP) is an immune-mediated vasculitis, and the formation of immune complexes may be triggered by exposure to Epstein-Barr virus (EBV) infection.

Methods: We performed a five-year case-control study to evaluate the epidemiology and clinical characteristics of HSP associated with EBV infection.

Results: The incidence of EBV-triggered HSP was 4.2%, while EBV infection in children with HSP was 0.9%; The EBV-triggered HSP cases had a significantly higher frequency of abdominal pain than the (MP)-triggered HSP group (χ2 = 8.024, p = 0.005); Significant differences were observed in the duration of abdominal pain (Z = -1.935, = 0.027) between the two groups; C3 (t = 9.709, < 0.001), IgA (t = 20.39, < 0.001) and IgG (t = 6.407, < 0.001) were significantly increased in the EBV infection group than those in the healthy control group. Notably, significantly higher proportion of CD19 (t = 6.773, < 0.001) and lower proportion of CD56 (t = 11.13, < 0.001) was found in EBV infection group compared with healthy control group. The IgA level was higher than that of the non-infectious group (t = 2.162, = 0.032), but their CD4/CD8 ratio (t = 10.070, < 0.001) and CD56 proportion (t = 2.096, = 0.037) were significantly lower.

Conclusions: Both cellular and humoral immunity were involved in the pathogenesis of EBV-triggered HSP, leading to increased production of inflammatory mediators and immunoglobulins. Those events may cause or promote the development of systemic vessel vasculitis.
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http://dx.doi.org/10.4084/MJHID.2021.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577555PMC
November 2021

Epidemiology and Clinical Characteristics of Henoch-Schönlein Purpura Associated with Infection in 131 Children in Hubei Province, China.

Mediterr J Hematol Infect Dis 2021 1;13(1):e2021037. Epub 2021 May 1.

Department of Laboratory, Maternal and Child Health Hospital of Hubei Province, China.

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http://dx.doi.org/10.4084/MJHID.2021.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114884PMC
May 2021
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